Citation:
Magiorkinis G, Paraskevis D, Vandamme AM, Magiorkinis E, Sypsa V, Hatzakis A. In vivo characteristics of human immunodeficiency virus type 1 intersubtype recombination: determination of hot spots and correlation with sequence similarity. J Gen VirolJ Gen VirolJ Gen Virol. 2003;84:2715-22.
Abstract:
Recombination plays a pivotal role in the evolutionary process of many different virus species, including retroviruses. Analysis of all human immunodeficiency virus type 1 (HIV-1) intersubtype recombinants revealed that they are more complex than described initially. Recombination frequency is higher within certain genomic regions, such as partial reverse transcriptase (RT), vif/vpr, the first exons of tat/rev, vpu and gp41. A direct correlation was observed between recombination frequency and sequence similarity across the HIV-1 genome, indicating that sufficient sequence similarity is required upstream of the recombination breakpoint. This finding suggests that recombination in vivo may occur preferentially during reverse transcription through the strand displacement-assimilation model rather than the copy-choice model.Notes:
Magiorkinis, GkikasParaskevis, DimitriosVandamme, Anne-MiekeMagiorkinis, EmmanouilSypsa, VanaHatzakis, AngelosengEngland2003/09/19 05:00J Gen Virol. 2003 Oct;84(Pt 10):2715-22. doi: 10.1099/vir.0.19180-0.
