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Triacylglycerols Based on 2-(N-tert-Butoxycarbonylamino)oleic Acid Are Potent Inhibitors of Pancreatic Lipase

Citation:

Magrioti V, Verger R, Constantinou-Kokotou V. Triacylglycerols Based on 2-(N-tert-Butoxycarbonylamino)oleic Acid Are Potent Inhibitors of Pancreatic Lipase. Journal of Medicinal Chemistry. 2004;47(2):288-291.

Abstract:

A novel class of potent human pancreatic lipase (HPL) inhibitors was developed. Triacylglycerol analogues containing 2-(N-tert-butoxycarbonylamino) fatty acids were synthesized, and their ability to form stable films at the air/water interface was studied. The inhibition of human digestive lipases by the compounds synthesized was studied by the monolayer technique, and the triesters of glycerol and 2-methylglycerol with 2-(N-tert-butoxycarbonylamino)oleic acid were found to be potent inhibitors of HPL.

Notes:

Cited By :12Export Date: 18 January 2017