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Evidence by molecular profiling for a placental origin of infantile hemangioma

Citation:

Barnes CM, Huang S, Kaipainen A, Sanoudou D, Chen EJ, Eichler GS, Guo Y, Yu Y, Ingber DE, Mulliken JB, et al. Evidence by molecular profiling for a placental origin of infantile hemangioma. Proc Natl Acad Sci U S AProc Natl Acad Sci U S AProc Natl Acad Sci U S A. 2005;102:19097-102.

Abstract:

The origin of the pathogenic endothelial cells in common infantile hemangioma is unknown. We show here that the transcriptomes of human placenta and infantile hemangioma are sufficiently similar to suggest a placental origin for this tumor, expanding on recent immunophenotypical studies that have suggested this possibility [North, P. E., et al. (2001) Arch. Dermatol. 137, 559-570]. The transcriptomes of placenta, hemangioma, and eight normal and diseased tissues were compared by hierarchical and nonhierarchical clustering analysis of >7,800 genes. We found that the level of transcriptome similarity between placenta and hemangioma exceeded that of any other tissue compared and paralleled that observed between a given tissue and its derived tumor, such as normal and cancerous lung. The degree of similarity was even greater when a subset of endothelial cell-specific genes was analyzed. Genes preferentially expressed in both placenta and hemangiomas were identified, including 17-beta hydroxysteroid dehydrogenase type 2 and tissue factor pathway inhibitor 2. These data demonstrate the value of global molecular profiling of tissues as a tool for hypothesis-driven research. Furthermore, it suggests that the unique self-limited growth of infantile hemangioma may, in fact, mirror the lifetime of placental endothelium.

Notes:

Barnes, Carmen MHuang, SuiKaipainen, ArjaSanoudou, DespinaChen, Emy JEichler, Gabriel SGuo, YuchunYu, YingIngber, Donald EMulliken, John BBeggs, Alan HFolkman, JudahFishman, Steven JengP01 NS40928/NS/NINDS NIH HHS/R01 AR044345/AR/NIAMS NIH HHS/R01 AR44345/AR/NIAMS NIH HHS/P01 CA045548/CA/NCI NIH HHS/P01 CA45548-18/CA/NCI NIH HHS/Research Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.2005/12/21 09:00Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19097-102. doi: 10.1073/pnas.0509579102. Epub 2005 Dec 19.