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{Molecular mechanisms of carfilzomib-induced cardiotoxicity in mice and the emerging cardioprotective role of metformin}

Citation:

Efentakis, P., Kremastiotis, G., Varela, A., Nikolaou, P. - E., Papanagnou, E. - D., Davos, C. H., Tsoumani, M., et al. (2019). {Molecular mechanisms of carfilzomib-induced cardiotoxicity in mice and the emerging cardioprotective role of metformin}. Blood, 133, 710–723. presented at the feb. Copy at http://www.tinyurl.com/y6jvkx4k

Abstract:

Cfz decreases left ventricular function in mice through increased PP2A activity and inhibition of AMPK$\alpha$/autophagy regulatory axes. Met preserves left ventricular function in mice by restoring AMPK$\alpha$ activation; thus, it emerges as a prophylactic therapy.

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