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Role of receptor for hyaluronic acid-mediated motility (RHAMM) in low molecular weight hyaluronan (LMWHA)-mediated fibrosarcoma cell adhesion

Citation:

Kouvidi K, Berdiaki A, Nikitovic D, Katonis P, Afratis N, Hascall VC, Karamanos NK, Tzanakakis GN. Role of receptor for hyaluronic acid-mediated motility (RHAMM) in low molecular weight hyaluronan (LMWHA)-mediated fibrosarcoma cell adhesion. J Biol ChemJ Biol Chem. 2011;286:38509-38520.

Abstract:

Hyaluronan (HA) modulates key cancer cell functions through interaction with its CD44 and receptor for hyaluronic acid-mediated motility (RHAMM) receptors. HA was recently found to regulate the migration of fibrosarcoma cells in a manner specifically dependent on its size. Here, we investigated the effect of HA/RHAMM signaling on the ability of HT1080 fibrosarcoma cells to adhere onto fibronectin. Low molecular weight HA (LMWHA) significantly increased (p

Notes:

Kouvidi, KaterinaBerdiaki, AikateriniNikitovic, DraganaKatonis, PavlosAfratis, NikosHascall, Vincent CKaramanos, Nikos KTzanakakis, George Neng2011/09/15J Biol Chem. 2011 Nov 4;286(44):38509-38520. doi: 10.1074/jbc.M111.275875. Epub 2011 Sep 13.