ABSTRACT Background: School professionals’ knowledge and skills regarding self-harming and drug and alcohol use in adolesence in Greece is limited and not thorougly studied. The present study aims to explore the perspectives of educators and school psychologists regarding self-harming and drug and alcohol use in adolescence in Greece their views of their roles, the role of schools and appropriate responses. Methods: Semi-structured interviews and thematic analysis were carried out to explore the perspectives of 12 women, all secondary school professionals, six secondary school teachers and six psychologists, regarding self-harming behaviors in adolescence. Results: The first research question focused on the understanding of self-harm and revealed that participants perceive self-harm mainly as self-cutting and bodily harm, failing to identify drug and alcohol misuse as interrelated risk factors. Regarding the second research question, regarding secondary school teachers and psychologists’ perspectives of their professional role and boundaries, it emerged that these are interconnected and that schools are failing in managing adolescents’ self-harming behaviors. The third research question concerned the range of appropriate responses as perceived by study participants. Conclusions: Secondary school teachers and psychologists in Greece, participating in the current study, agreed that further training, careful assessment and collaboration between schools, families and experts is required.