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Design, synthesis and antiproliferative activity of novel aminosubstituted benzothiopyranoisoindoles

Citation:

Christodoulou, A., Kostakis, I. K., Kourafalos, V., Pouli, N., Marakos, P., Trougakos, I. P., & Tsitsilonis, O. E. (2011). Design, synthesis and antiproliferative activity of novel aminosubstituted benzothiopyranoisoindoles. Bioorganic & Medicinal Chemistry LettersBioorganic & Medicinal Chemistry Letters. Elsevier Ltd. Copy at http://www.tinyurl.com/y2w7pu4x

Abstract:

The synthesis of a number of new benzothiopyrano[4,3,2-cd]isoindole aminoderivatives designed as structural analogues of the key metabolite of the anticancer agent Ledacrine (nitracrine) and their in vitro cytotoxic activity evaluation against HCT-116, MES-SA, and MES-SA/Dx cancer cell lines is reported. The majority of the derivatives possessed noticeable cytotoxicity in a low μM range indicating an interesting structure-activity relationship. © 2011 Elsevier Ltd. All rights reserved.

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