Publications by Type: Journal Article

In this work, we explore the applicability of standard theoretical models of accretion to the observed properties of M51 ULX-7. The spin-up rate and observed X-ray luminosity are evidence of a neutron star with a surface magnetic field of 2-7 × 1013 G, rotating near equilibrium. Analysis of the X-ray light curve of the system (Swift/XRT data) reveals the presence of a ∼39 d superorbital period. We argue that the superorbital periodicity is due to disc precession, and that material is accreted on to the neutron star at a constant rate throughout it. Moreover, by attributing this modulation to the free precession of the neutron star we estimate a surface magnetic field strength of 3-4 × 1013 G. The agreement of these two independent estimates provide strong constraints on the surface polar magnetic field strength of the NS.

This paper studies on “Early Warning Systems” (EWS) by investigating possible contagion risks, based on structured financial networks. Early warning indicators improve standard crisis prediction models performance. Using network analysis and machine learning algorithms we find evidence of contagion risk on the dates where we observe significant increase in correlations and centralities. The effectiveness of machine learning reached 98.8%, making the predictions extremely accurate. The model provides significant information to policymakers and investors about employing the financial network as a useful tool to improve portfolio selection by targeting assets based on centrality.

Magneto-optical materials have become a key tool in functional nanophotonics, mainly due to their ability to offer active tuning between two different operational states in subwavelength structures. In the long-wavelength limit, such states may be considered as the directional forward- and back-scattering operations, due to the interplay between magnetic and electric dipolar modes, which act as equivalent Huygens sources. In this work, on the basis of full-wave electrodynamic calculations based on a rigorous volume integral equation (VIE) method, we demonstrate the feasibility of obtaining magnetically-tunable directionality inversion in spherical microresonators (THz antennas) coated by magnetooptical materials. In particular, our analysis reveals that when a high-index dielectric is coated with a magnetooptical material, we can switch the back-scattering of the whole particle to forward-scattering simply by turning off/ on an external magnetic field bias. The validity of our calculations is confirmed by reproducing the above two-state operation, predicted by the VIE, with full-wave finite-element commercial software. Our results are of interest for the design of state-of-the-art active metasurfaces and metalenses, as well as for functional nanophotonic structures, and scattering and nanoantennas engineering. © 2020 Grigorios P. Zouros et al., published by De Gruyter. This work is licensed under the Creative Commons Attribution 4.0 International License.

 

The sarcomere is the basic unit of the myofibrils, which mediate skeletal and cardiac Muscle contraction. Two transverse structures, the Z-disc and the M-band, anchor the thin (actin and associated proteins) and thick (myosin and associated proteins) filaments to the elastic filament system composed of titin. A plethora of proteins are known to be integral or associated proteins of the Z-disc and its structural and signalling role in muscle is better understood, while the molecular constituents of the M-band and its function are less well defined. Evidence discussed here suggests that the M-band is important for managing force imbalances during active muscle contraction. Its molecular composition is fine-tuned, especially as far as the structural linkers encoded by members of the myomesin family are concerned and depends on the specific mechanical characteristics of each particular muscle fibre type. Muscle activity signals from the M-band to the nucleus and affects transcription of sarcomeric genes, especially via serum response factor (SRF). Due to its important role as shock absorber in contracting muscle, the M-band is also more and more recognised as a contributor to muscle disease.

Chronic pain manifests in multiple disorders and is highly debilitating. While its pathophysiology is not fully understood, the involvement of the mesocorticolimbic monoaminergic systems have been shown to play a critical role in chronic pain emergence and/or maintenance. In this study, we analyzed the levels of monoamines dopamine (DA), noradrenaline (NA) and serotonin (5-HT) in mesocorticolimbic areas - medial prefrontal cortex, orbitofrontal cortex, striatum, nucleus accumbens and amygdala - 1 month after a neuropathic lesion, Spared Nerve Injury (SNI). In SNI animals, were observed a marginal decrease of DA and 5-HT in the striatum and a rightward shift in the levels of NA in the nucleus accumbens. While mesocorticolimbic monoamines might be relevant for chronic pain pathophysiology its content appears to be relatively unaffected in our experimental conditions.

Aging research aims at developing interventions that delay normal aging processes and some related pathologies. Recently, many compounds and extracts from natural products have been shown to delay aging and/or extend lifespan. Marine sponges and their associated microorganisms have been found to produce a wide variety of bioactive secondary metabolites; however, those from the Southwest of the Indian Ocean are much less studied, especially regarding anti-aging activities. In this study, the microbial diversity of the marine sponge Scopalina hapalia was investigated by metagenomic analysis. Twenty-six bacterial and two archaeal phyla were recovered from the sponge, of which the Proteobacteria phylum was the most abundant. In addition, thirty isolates from S. hapalia were selected and cultivated for identification and secondary metabolites production. The selected isolates were affiliated to the genera Bacillus, Micromonospora, Rhodoccocus, Salinispora, Aspergillus, Chaetomium, Nigrospora and unidentified genera related to the family Thermoactinomycetaceae. Crude extracts from selected microbial cultures were found to be active against seven targets i.e., elastase, tyrosinase, catalase, sirtuin 1, Cyclin-dependent kinase 7 (CDK7), Fyn kinase and proteasome. These results highlight the potential of microorganisms associated with a marine sponge from Mayotte to produce anti-aging compounds. Future work will focus on the isolation and the characterization of bioactive molecules.

Ovarian cancer (OC) remains a leading cause of gynecological cancer-related death worldwide, characterized by poor 5-year survival. Molecular markers could serve as crucial tools of personalized prognosis and therapy. Herein, we present miR-181a as novel predictor of OC prognosis, using five independent OC cohorts. In particular, a screening (n = 81) and an institutionally independent validation (n = 100, OVCAD multicenter study) serous OC (SOC) cohorts were analyzed. Bagnoli et al (2016) OC179 (n = 124) to OC133 (n = 100) and TCGA (n = 489) served as external validation cohorts. Patients' survival and disease progression were assessed as clinical endpoint events. Bootstrap analysis was performed for internal validation and decision curve analysis was utilized to evaluate clinical benefit. miR-181a overexpression was unveiled as powerful and independent molecular predictor of patients' poor survival and higher risk for disease progression after debulking surgery and platinum-based chemotherapy. Analysis of the OVCAD institutionally independent cohort, as well as of Bagnoli et al. and TCGA external cohorts further confirmed the unfavorable prognostic nature of miR-181a overexpression in SOC. Strikingly, multivariate prognostic models incorporating miR-181a with established disease markers clearly improved patients' risk-stratification and offered superior clinical benefit in OC prognostication. Conclusively, miR-181a evaluation could augment prognostic accuracy and support precision medicine decisions in OC.

Ovarian cancer (OC) accounts for the most gynecological cancer-related deaths in developed countries. Unfortunately, the lack of both evident early symptoms and effective asymptomatic population screening results in late diagnosis and inevitably poor prognosis. Hence, it is urgent to identify novel molecular markers to support personalized prognosis. In the present study, we have analyzed the clinical significance of miR-203 in OC using two institutionally independent cohorts. miR-203 levels were quantified in a screening (n = 125) and a validation cohort (n = 100, OVCAD multicenter study). Survival analysis was performed using progression and death as clinical endpoint events. Internal validation was conducted by bootstrap analysis, and decision curve analysis was used to evaluate the clinical benefit. Increased miR-203 levels in OC patients were correlated with unfavorable prognosis and higher risk for disease progression, independently of FIGO stage, tumor grade, residual tumor after surgery, chemotherapy response and age. The analysis of the institutionally independent validation cohort (OVCAD study) clearly confirmed the shorter survival outcome of the patients overexpressing miR-203. Additionally, integration of miR-203 levels with the established disease prognostic markers led to a superior stratification of OC patients that can ameliorate prognosis and benefit patient clinical management. In this regard, miR-203 expression constitutes a novel independent molecular marker to improve patients' prognosis in OC.

Neurodegenerative diseases are strongly age-related and currently cannot be cured, with a surge of patient numbers in the coming decades in view of the emerging worldwide ageing population, bringing healthcare and socioeconomic challenges. Effective therapies are urgently needed, and are dependent on new aetiological mechanisms. In neurons, efficient clearance of damaged mitochondria, through the highly evolutionary conserved cellular process termed mitophagy, plays a fundamental role in mitochondrial and metabolic homeostasis, energy supply, neuronal survival, and health. Conversely, defective mitophagy leads to accumulation of damaged mitochondria and cellular dysfunction, contributing to ageing and age-predisposed neurodegeneration. Here, we discuss the contribution of defective mitophagy in these diseases, and underlying molecular mechanisms, and highlight novel therapeutics based on new discovered mitophagy-inducing strategies.

Battling human neurodegenerative pathologies and managing their pervasive socioeconomic impact is becoming a global priority. Notwithstanding their detrimental effects on the human life quality and the healthcare system, the majority of human neurodegenerative disorders still remain incurable and non-preventable. Therefore, the development of novel therapeutic interventions against such maladies is becoming a pressing urgency. Age-associated deterioration of neuronal circuits and function is evolutionarily conserved in organisms as diverse as the lowly worm Caenorhabditis elegans and humans, signifying similarities in the underlying cellular and molecular mechanisms. C. elegans is a highly malleable genetic model, which offers a well-characterized nervous system, body transparency and a diverse repertoire of genetic and imaging techniques to assess neuronal activity and quality control during ageing. Here, we introduce and describe methodologies utilizing some versatile nematode models, including hyperactivated ion channel-induced necrosis (e.g., deg-3(d) and mec-4(d)) and protein aggregate (e.g., alpha-syunclein and poly-glutamate)-induced neurotoxicity, to monitor and dissect the cellular and molecular underpinnings of age-related neuronal breakdown. A combination of these animal neurodegeneration models, together with genetic and pharmacological screens for cell death modulators will lead to an unprecedented understanding of age-related breakdown of neuronal function and will provide critical insights with broad relevance to human health and quality of life.

BACKGROUND.: The aim of the current study was to explore the changing interrelationships among clinical variables through the stages of schizophrenia in order to assemble a comprehensive and meaningful disease model. METHODS.: Twenty-nine centers from 25 countries participated and included 2358 patients aged 37.21 ± 11.87 years with schizophrenia. Multiple linear regression analysis and visual inspection of plots were performed. RESULTS.: The results suggest that with progression stages, there are changing correlations among Positive and Negative Syndrome Scale factors at each stage and each factor correlates with all the others in that particular stage, in which this factor is dominant. This internal structure further supports the validity of an already proposed four stages model, with positive symptoms dominating the first stage, excitement/hostility the second, depression the third, and neurocognitive decline the last stage. CONCLUSIONS.: The current study investigated the mental organization and functioning in patients with schizophrenia in relation to different stages of illness progression. It revealed two distinct "cores" of schizophrenia, the "Positive" and the "Negative," while neurocognitive decline escalates during the later stages. Future research should focus on the therapeutic implications of such a model. Stopping the progress of the illness could demand to stop the succession of stages. This could be achieved not only by both halting the triggering effect of positive and negative symptoms, but also by stopping the sensitization effect on the neural pathways responsible for the development of hostility, excitement, anxiety, and depression as well as the deleterious effect on neural networks responsible for neurocognition.

This study quantifies the effects of the Fed’s quantitative easing (QE) and tapering programs’ announcements on professionals’ consensus forecasts of U.S. macroeconomic and financial variables at different forecast horizons. The results of a vector autoregression (VAR) analysis show that the first QE (QE1) program is more effective in terms of significantly affecting the variability of near and medium term forecasts on GDP, inflation and short-term interest rates. This is not the case for these variables of long forecast horizons across all QE/tapering announcements, the forecasts of U.S. currency and long-term rates present significant short-lived responses, while the tapering displays a dominant effect on the volatility of long-term rates across long-term forecast horizons. A dynamic correlation analysis among different horizon forecasts also reveals that the Fed successfully anchor inflation and real economic growth expectations during the expansionary policy (QE) periods. Additional findings show the anchoring of the expectations across different horizons on short-term rates, as opposed to long-term rates, during the QE1 program. During the contractionary (tapering) period, the decrease in the correlations among different horizons for the short-term rates’ forecasts is a sign that the Fed increases the range of possible outcomes and highlights a signal of a monetary policy change.

BACKGROUND: The spread of SARS-CoV-2 generated an unprecedented global public health crisis. Soon after Asia, Europe was seriously affected. Many countries, including Romania, adopted lockdown measures to limit the outbreak. AIM: We performed a molecular epidemiology analysis of SARS-CoV-2 viral strains circulating in Romania during the first two months of the epidemic in order to detect mutation profiles and phylogenetic relatedness. METHODS: Respiratory samples were directly used for shotgun sequencing. RESULTS: All Romanian sequences belonged to lineage B, with a different subtype distribution between northern and southern regions (subtype B.1.5 and B.1.1). Phylogenetic analysis suggested that the Romanian epidemic started with multiple introduction events from other European countries followed by local transmission. Phylogenetic links between northern Romania and Spain, Austria, Scotland and Russia were observed, as well as between southern Romania and Switzerland, Italy, France and Turkey. One viral strain presented a previously unreported mutation in the Nsp2 gene, namely K489E. Epidemiologically-defined clusters displayed specific mutations, suggesting molecular signatures for strains coming from areas that were isolated during the lockdown. CONCLUSIONS: Romanian epidemic was initiated by multiple introductions from European countries followed by local transmissions. Different subtype distribution between northern and southern Romania was observed after two months of the pandemic.

Asynchronous movement of the carotid atheromatous plaque from B-mode ultrasound has been previously reported, and associated with higher risk of stroke, but not quantitatively estimated. Based on the hypothesis that asynchronous plaque motion is associated with vulnerable plaque, in this study, synchronisation patterns of different tissue areas were estimated using cross-correlations of displacement waveforms. In 135 plaques (77 subjects), plaque radial deformation was synchronised by approximately 50% with the arterial diameter, and the mean phase shift was 0.4 s. Within the plaque, the mean phase shifts between the displacements of the top and bottom surfaces were 0.2 s and 0.3 s, in the radial and longitudinal directions, respectively, and the synchronisation about 80% in both directions. Classification of phase-shift-based features using Random Forests yielded Area-Under-the-Curve scores of 0.81, 0.79, 0.89 and 0.90 for echogenicity, symptomaticity, stenosis degree and plaque risk, respectively. Statistical analysis showed that echolucent, high-stenosis and high-risk plaques exhibited higher phase shifts between the radial displacements of their top and bottom surfaces. These findings are useful in the study of plaque kinematics.

The IceCube report of a ∼ 3.5σ excess of 13 ± 5 neutrino events in the direction of the blazar TXS 0506+056 in 2014-2015 and the 2017 detection of a high-energy neutrino event, IceCube-170922A, during a gamma-ray flare from the same blazar, have revived the interest in scenarios for neutrino production in blazars. We perform comprehensive analyses on the long-term electromagnetic emission of TXS 0506+056 using optical, X-ray, and gamma-ray data from the All-Sky Automated Survey for Supernovae, the Neil Gehrels Swift Observatory, Monitor of All-sky X-ray Image, and the Fermi Large Area Telescope. We also perform numerical modeling of the spectral energy distributions (SEDs) in four epochs prior to 2017 with contemporaneous gamma-ray and lower-energy (optical and/or X-ray) data. We find that the multi-epoch SEDs are consistent with a hybrid leptonic scenario, where the gamma-rays are produced in the blazar zone via external inverse Compton scattering of accelerated electrons, and high-energy neutrinos are produced via the photomeson production process of co-accelerated protons. The multi-epoch SEDs can be satisfactorily explained with the same jet parameters and variable external photon density and electron luminosity. Using the maximal neutrino flux derived for each epoch, we put an upper limit of ∼0.4-2 on the muon neutrino number in 10 years of IceCube observations. Our results are consistent with the IceCube-170922A detection, which can be explained as an upper fluctuation from the average neutrino rate expected from the source, but in strong tension with the 2014-2015 neutrino flare.

The IceCube report of a ∼ 3.5σ excess of 13 ± 5 neutrino events in the direction of the blazar TXS 0506+056 in 2014-2015 and the 2017 detection of a high-energy neutrino event, IceCube-170922A, during a gamma-ray flare from the same blazar, have revived the interest in scenarios for neutrino production in blazars. We perform comprehensive analyses on the long-term electromagnetic emission of TXS 0506+056 using optical, X-ray, and gamma-ray data from the All-Sky Automated Survey for Supernovae, the Neil Gehrels Swift Observatory, Monitor of All-sky X-ray Image, and the Fermi Large Area Telescope. We also perform numerical modeling of the spectral energy distributions (SEDs) in four epochs prior to 2017 with contemporaneous gamma-ray and lower-energy (optical and/or X-ray) data. We find that the multi-epoch SEDs are consistent with a hybrid leptonic scenario, where the gamma-rays are produced in the blazar zone via external inverse Compton scattering of accelerated electrons, and high-energy neutrinos are produced via the photomeson production process of co-accelerated protons. The multi-epoch SEDs can be satisfactorily explained with the same jet parameters and variable external photon density and electron luminosity. Using the maximal neutrino flux derived for each epoch, we put an upper limit of ∼0.4-2 on the muon neutrino number in 10 years of IceCube observations. Our results are consistent with the IceCube-170922A detection, which can be explained as an upper fluctuation from the average neutrino rate expected from the source, but in strong tension with the 2014-2015 neutrino flare.

A thorough theoretical study of the optical properties of periodic Si nanosphere arrays is undertaken, placing a particular emphasis on the synergy between multipolar, electric and magnetic, Mie resonances, which occur in high-refractive-index nanoparticles and can lead to a rich variety of phenomena ranging from perfect reflection to controlled diffraction. Systematic calculations using the layer-multiple-scattering method, which we properly extended to describe periodic arrays with many different scatterers per unit cell, in conjunction with finite-element simulations are presented. It is shown that rectangular arrays of pairs of Si nanospheres can efficiently diffract light in reflection or transmission mode at large angles as well as split light with minimum backreflection by properly adjusting the geometry of the structure. Our rigorous full-electrodynamic calculations highlight the importance of higher-order multipoles, which are not taken into account in the commonly employed dipole approximation, in the description of these effects.

The paleoenvironmental evolution of Lake Ismarida in Thrace (Northern Greece) is revealed by the combined lithological, micropaleontological (benthic foraminifera, pollen and NPPS), molluscan analyses, magnetic susceptibility measurement and radiocarbon dating of a 5.8-m long sediment core. The mid Holocene evolution of the lake area is evidenced by the documentation of four sedimentary Units in the core ISMR-2, corresponding to four distinct evolutionary stages: (1) during ∼5500-3500 cal yr BP the lake area was a shallow marine environment characterized by an Ammonia beccarii, small rotaliids, miliolids, Bittium reticulatum and Veneridae spp. assemblage, marine dinoflagellate cysts, and low magnetic susceptibility values; (2) during ∼3500-3000 cal BP the environment is gradually tending to more isolated conditions forming an open lagoon, characterized by marine and euryhaline fauna and low magnetic susceptibility values; (3) during 3000 cal yr BP, the open lagoon presented a transition to an oligohaline inner lagoon, characterized by an Ammonia tepida, Haynesina germanica, Aubignyna perlucida, Pirenella conica, Cerastoderma glaucum and Abra spp. assemblage, sedges and aquatic vegetation. This restricted, entirely isolated from the sea inner lagoon could be definitely used as the landmark of the Lake Ismaris from Heorodotus, while describing the march of Xerxes through Thrace in 480 B.C.; (4) since ∼2000 cal yr BP to the present, the Lake Ismarida is formed, characterized by fresh-water indicators and aquatic pollen, Pseudoschizaea and high magnetic susceptibility values. Finally, the progradation of the Filiouris River deltaic deposits resulted to a 4 km wide deltaic plain between Lake Ismarida and the nowadays coastline. Pollen assemblages record the dominance of a rather rich deciduous forest in the area with traces of human presence in the lower part of the sequence, whereas the opening of the plant landscape under the increasing human pressure is evidenced after ∼ 3000 cal yr BP. Finally, an open vegetation pattern, contemporaneous with the retreat of forest vegetation, is evidenced in the area already before 2000 cal yr BP.

Our aim was to investigate the dispersal patterns and parameters associated with local molecular transmission clusters (MTCs) of subtypes A1 and B in Greece (predominant HIV-1 subtypes). The analysis focused on 1751 (28.4%) and 2575 (41.8%) sequences of subtype A1 and B, respectively. Identification of MTCs was based on phylogenetic analysis. The analyses identified 38 MTCs including 2-1518 subtype A1 sequences and 168 MTCs in the range of 2-218 subtype B sequences. The proportion of sequences within MTCs was 93.8% (1642/1751) and 77.0% (1982/2575) for subtype A1 and B, respectively. Transmissions within MTCs for subtype A1 were associated with risk group (Men having Sex with Men vs. heterosexuals, OR = 5.34, p < 0.001) and Greek origin (Greek vs. non-Greek origin, OR = 6.05, p < 0.001) and for subtype B, they were associated with Greek origin (Greek vs. non-Greek origin, OR = 1.57, p = 0.019), younger age (OR = 0.96, p < 0.001), and more recent sampling (time period: 2011-2015 vs. 1999-2005, OR = 3.83, p < 0.001). Our findings about the patterns of across and within country dispersal as well as the parameters associated with transmission within MTCs provide a framework for the application of the study of molecular clusters for HIV prevention.

Guided by the self-determination theory, this weekly diary study tested a process model in which week-to-week mother-reported interparental conflict and perceived partner responsiveness were associated with maternal autonomy support by means of maternal psychological need satisfaction. During six consecutive weeks, 258 mothers (Mage = 41.71 years) and their 157 adolescents (51.4% females, Mage = 14.92 years) from Turkey provided weekly reports of the study variables via an online survey. Multilevel analyses showed that maternal need satisfaction was predicted by lower levels of interparental conflict and greater levels of perceived partner responsiveness. Maternal need satisfaction, in turn, was positively associated with maternal and adolescent reports of maternal autonomy support. Further, these week-to-week associations were partly moderated by maternal perfectionism. The results underscore the dynamic nature of the intra-family relationships, the important role of particular conditions in which mothers may become more autonomy supportive, and the necessity to consider mother’s personal characteristics while examining these dynamics.

Maintenance of neuronal homeostasis is a challenging task, due to unique cellular organization and bioenergetic demands of post-mitotic neurons. It is increasingly appreciated that impairment of mitochondrial homeostasis represents an early sign of neuronal dysfunction that is common in both age-related neurodegenerative as well as in neurodevelopmental disorders. Mitochondrial selective autophagy, known as mitophagy, regulates mitochondrial number ensuring cellular adaptation in response to several intracellular and environmental stimuli. Mounting evidence underlines that deregulation of mitophagy levels has an instructive role in the process of neurodegeneration. Although mitophagy induction mediates the elimination of damaged mitochondria and confers neuroprotection, uncontrolled runaway mitophagy could reduce mitochondrial content overstressing the remaining organelles and eventually triggering neuronal cell death. Unveiling the molecular mechanisms of neuronal mitophagy and its intricate role in neuronal survival and cell death, will assist in the development of novel mitophagy modulators to promote cellular and organismal homeostasis in health and disease.

The IceCube collaboration reported an ∼3.5σ excess of 13 ± 5 neutrino events in the direction of the blazar TXS 0506+056 during an ∼6 month period in 2014-2015, as well as the (∼3σ) detection of a high-energy muon neutrino during an electromagnetic flare in 2017. We explore the possibility that the 2014-2015 neutrino excess and the 2017 multimessenger flare are both explained in a common physical framework that relies on the emergence of a relativistic neutral beam in the blazar jet due to interactions of accelerated cosmic rays (CRs) with photons. We demonstrate that the neutral beam model provides an explanation for the 2014-2015 neutrino excess without violating X-ray and γ-ray constraints and yields results consistent with the detection of one high-energy neutrino during the 2017 flare. If both neutrino associations with TXS 05065+056 are real, our model requires that (I) the composition of accelerated CRs is light, with a ratio of helium nuclei to protons ≳5; (II) a luminous external photon field (∼1046 erg s-1) variable (on yearlong timescales) is present; and (III) the CR injection luminosity, as well as the properties of the dissipation region (I.e., Lorentz factor, magnetic field, and size), vary on yearlong timescales.

A novel finite-time convergent zeroing neural network (ZNN) based on varying gain parameter for solving time-varying (TV) problems is presented. The model is based on the improvement and generalization of the finite-time ZNN (FTZNN) dynamics by means of the varying-parameter ZNN (VPZNN) dynamics, and termed as VPFTZNN. More precisely, the proposed model replaces fixed and large values of the scaling parameter by an appropriate time-dependent gain parameter, which leads to a faster and bounded convergence of the error function in comparison to previous ZNN methods. The convergence properties of the proposed VPFTZNN dynamical evolution in its generic form is verified. Particularly, VPFTZNN for solving linear matrix equations and for computing generalized inverses are investigated theoretically and numerically. Moreover, the proposed design is applicable in solving the TV matrix inversion problem, solving the Lyapunov and Sylvester equation as well as in approximating the matrix square root. Theoretical analysis as well as simulation results validate the effectiveness of the introduced dynamical evolution. The main advantages of the proposed VPFTZNN dynamics are their generality and faster finite-time convergence with respect to FTZNN models.

The treatment of AL amyloidosis aims to eradicate the plasma cell clone and eliminate toxic free light chain production. Only in a minority of patients the plasma cell clone is completely eradicated; residual light chain production may still exist while clonal relapse may occur. We used sensitive next-generation flow cytometry (NGF) to detect minimal residual disease (MRD) in AL amyloidosis patients at complete haematologic response. MRD evaluation was feasible in 51 of 52 (98{%}) tested patients and at a median sensitivity of 2.3 × 10−6 MRD was undetectable in 23 (45{%}). An organ response occurred in 86{%} of MRDneg vs 77{%} in MRDpos; renal response in 15/17(88{%}) of MRDneg vs in 14/16(87.5{%}) of MRDpos and cardiac response in 10/10(100{%}) of MRDneg vs 11/15(73{%}) of MRDpos patients. After a median follow-up of 24 months post MRD testing, no MRDneg patient had a haematologic relapse vs 6/28(21{%}) MRDpos (p =.029). Pooling haematologic and organ progressions, 9 (32{%}) MRDpos patients had disease progression vs only 1 (4{%}) MRDneg patient (p =.026). In conclusion, MRD detection using NGF has profound clinical implications, so that AL patients with undetectable MRD have a very high probability of organ response and a very low probability of haematologic relapse.

Following the detection of recent X-ray activity from the Be X-ray binary pulsar 1A 0535+262 on 2020 November 6 (ATel #14157), the Neutron Star Interior Composition Explorer (NICER) has observed the system at multiple epochs.

Following the SRG/eROSITA discovery of a strong outburst from the LMC Be/X-ray binary RX J0529.8-6556 (Haberl et al., ATEL #13828) we triggered NICER ToO observations to search for pulsations and obtain high-quality spectra.

In their paper in Optica 6, 104 (2019), Mann et al. claim that linear, time-invariant nonreciprocal structures cannot overcome the time-bandwidth limit and do not exhibit an advantage over their reciprocal counterparts, specifically with regard to their time-bandwidth performance. In this Comment, we argue that these conclusions are unfounded. On the basis of both rigorous full-wave simulations and insightful physical justifications, we explain that the temporal coupled-mode theory, on which Mann et al. base their main conclusions, is not suited for the study of nonreciprocal trapped states, and instead direct numerical solutions of Maxwell’s equations are required. Based on such an analysis, we show that a nonreciprocal terminated waveguide, resulting in a trapped state, clearly outperforms its reciprocal counterpart; i.e., both the extraordinary time-bandwidth performance and the large field enhancements observed in such modes are a direct consequence of nonreciprocity. © 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

Trans-crocin 4 (TC4) is an important carotenoid constituent of saffron showing potential activity against Alzheimer's Disease (AD) due to its antioxidant and antiamyloidogenic properties. Metabolomics is an emerging scientific field that enhances biomarker discovery and reveals underlying biochemical mechanisms aiming towards the early subclinical diagnosis of diseases. To date, there are no reports on the changes induced to mice plasma metabolome after TC4 administration. We report a novel untargeted UHPLC-ESI HRMS metabolomics strategy to determine the alteration of the metabolic fingerprint following i.p. administration of TC4 in male and female mice. Blood samples from fiftysix mice treated with TC4 as well as from control animals were analyzed with UHPLC-ESI HRMS. Statistical evaluation of the results was achieved by multivariate analysis (MVA), i.e., principal component analysis (PCA), Partial Least Squares-Discriminant Analysis (PLS-DA) in order to discover the variables that contributed to the discrimination between treated and untreated groups which were identified by online database searching (e.g., Metlin, HMDB, KEGG) aided by chemometric processing, e.g., covariance searching etc. Due to the high variability imposed by various factors, e.g., sex of the animals participating in the study, administration dose and time-points of sacrifice, multilevel sparse PLS-DA analysis, e.g., splitting variation to each individual component, has been employed as a more efficient approach for such designs. This methodology allowed the identification of the time sequence of metabolome changes due to the administration of TC4, whereas a sex-related effect on the metabolome is indicated, denoting that the administration in both sexes is indispensable in order to acquire safe conclusions as reliable metabolome pictures. The results demonstrated a number of annotated metabolites playing a potential role in neuroprotection while they are closely related to AD. Moreover, five additional annotated metabolites were involved in the steroid biosynthesis pathway while two of them may be considered as putative neuroprotective agents.

Trans-crocin 4 (TC4) is an important carotenoid constituent of saffron showing potential activity against Alzheimer's Disease (AD) due to its antioxidant and antiamyloidogenic properties. Metabolomics is an emerging scientific field that enhances biomarker discovery and reveals underlying biochemical mechanisms aiming towards the early subclinical diagnosis of diseases. To date, there are no reports on the changes induced to mice plasma metabolome after TC4 administration. We report a novel untargeted UHPLC-ESI HRMS metabolomics strategy to determine the alteration of the metabolic fingerprint following i.p. administration of TC4 in male and female mice. Blood samples from fiftysix mice treated with TC4 as well as from control animals were analyzed with UHPLC-ESI HRMS. Statistical evaluation of the results was achieved by multivariate analysis (MVA), i.e., principal component analysis (PCA), Partial Least Squares-Discriminant Analysis (PLS-DA) in order to discover the variables that contributed to the discrimination between treated and untreated groups which were identified by online database searching (e.g., Metlin, HMDB, KEGG) aided by chemometric processing, e.g., covariance searching etc. Due to the high variability imposed by various factors, e.g., sex of the animals participating in the study, administration dose and time-points of sacrifice, multilevel sparse PLS-DA analysis, e.g., splitting variation to each individual component, has been employed as a more efficient approach for such designs. This methodology allowed the identification of the time sequence of metabolome changes due to the administration of TC4, whereas a sex-related effect on the metabolome is indicated, denoting that the administration in both sexes is indispensable in order to acquire safe conclusions as reliable metabolome pictures. The results demonstrated a number of annotated metabolites playing a potential role in neuroprotection while they are closely related to AD. Moreover, five additional annotated metabolites were involved in the steroid biosynthesis pathway while two of them may be considered as putative neuroprotective agents.

Recent modeling of Neutron Star Interior Composition Explorer (NICER) observations of the millisecond pulsar PSR J0030+0451 suggests that the magnetic field of the pulsar is non-dipolar. We construct a magnetic field configuration where foot points of the open field lines closely resemble the hotspot configuration from NICER observations. Using this magnetic field as input, we perform force-free simulations of the magnetosphere of PSR J0030+0451, showing the three-dimensional structure of its plasma-filled magnetosphere. Making simple and physically motivated assumptions about the emitting regions, we are able to construct the multiwavelength lightcurves that qualitatively agree with the corresponding observations. The agreement suggests that multipole magnetic structures are the key to modeling this type of pulsar, and can be used to constrain the magnetic inclination angle and the location of radio emission.

The computational study of x-pinch plasmas driven by pulsed power generators demands the development of advanced numerical models and simulation schemes, able to enlighten the experiments. The capabilities of PLUTO code are here extended to enable the investigation of low current produced x-pinch plasmas. The numerical modules of the code used and modified are presented and discussed. The simulations results are compared to experiments, carried out on a table-top pulsed power plasma generator implemented in a mode of producing a peak current of ∼45 kA with a rise time (10%-90%) of 50 ns, loaded with Tungsten wires. The structural evolution of plasma density is studied and its influence on the magnetic field is analyzed with the help of the new simulation data. The simulated areal mass density is compared with the experimentally measured dense opaque region to enlighten the dense plasma evolution. In addition, the measured areal electron density is compared to the simulation results. Moreover, the new simulation data offer valuable insights to the main jet formation mechanisms, which are further analyzed and discussed in relation to the influence of the J× B force and the momentum.

The computational study of x-pinch plasmas driven by pulsed power generators demands the development of advanced numerical models and simulation schemes, able to enlighten the experiments. The capabilities of PLUTO code are here extended to enable the investigation of low current produced x-pinch plasmas. The numerical modules of the code used and modified are presented and discussed. The simulations results are compared to experiments, carried out on a table-top pulsed power plasma generator implemented in a mode of producing a peak current of ∼45 kA with a rise time (10%-90%) of 50 ns, loaded with Tungsten wires. The structural evolution of plasma density is studied and its influence on the magnetic field is analyzed with the help of the new simulation data. The simulated areal mass density is compared with the experimentally measured dense opaque region to enlighten the dense plasma evolution. In addition, the measured areal electron density is compared to the simulation results. Moreover, the new simulation data offer valuable insights to the main jet formation mechanisms, which are further analyzed and discussed in relation to the influence of the J× B force and the momentum.

The increased development of computer vision technology combined with the increased availability of innovative platforms with ultra-high-resolution sensors, has generated new opportunities and fields for investigation in the engineering geology domain in general and landslide identification and characterization in particular. During the last decade, the so-called Unmanned Aerial Vehicles (UAVs) have been evaluated for diverse applications such as 3D terrain analysis, slope stability, mass movement hazard and risk management. Their advantages of detailed data acquisition at a low cost and effective performance identifies them as leading platforms for site-specific 3D modelling. In this study, the proposed methodology has been developed based on Object-Based Image Analysis (OBIA) and fusion of multivariate data resulted from UAV photogrammetry processing in order to take full advantage of the produced data. Two landslide case studies within the territory of Greece, with different geological and geomorphological characteristics, have been investigated in order to assess the developed landslide detection and characterization algorithm performance in distinct scenarios. The methodology outputs demonstrate the potential for an accurate characterization of individual landslide objects within this natural process based on ultra high-resolution data from close range photogrammetry and OBIA techniques for landslide conceptualization. This proposed study shows that UAV-based landslide modelling on the specific case sites provides a detailed characterization of local scale events in an automated sense with high adaptability on the specific case site.

In this paper, for the first time in literature, we introduce one-sided weighted inverses and extend the notions of one-sided inverses, outer inverses and inverses along given elements. Although our results are new and in the matrix case, we decided to present them in tensor space with reshape operator. For this purpose, a left and right (M,N)-weighted (B,C)-inverse and the (M,N)-weighted (B,C)-inverse of a tensor are defined. Additionally, necessary and sufficient conditions for the existence of these new inverses are presented. We describe the sets of all left (or right) (M,N)-weighted (B,C)-inverses of a given tensor. As consequences of these results, we consider the one-sided (B,C)-inverse, (B,C)-inverse, one-sided inverse along a tensor and inverse along a tensor. Further, we introduce a (M,N)-weighted (B,C)-outer inverse and a W-weighted (B,C)-outer inverse of tensors with a few characterizations. Then, corresponding algorithms for computing various types of outer inverses of tensors are proposed, implemented and tested. The prowess of the proposed inverses are demonstrated for finding the solution of Poisson problem and the restoration of 3D color images.

Chemical study of the CH2Cl2−MeOH (1:1) extract from the sponge Haliclona sp. collected in Mayotte highlighted three new long-chain highly oxygenated polyacetylenes, osirisynes G-I (1–3) together with the known osirisynes A (4), B (5), and E (6). Their structures were elucidated by 1D and 2D NMR spectra and HRESIMS and MS/MS data. All compounds were evaluated on catalase and sirtuin 1 activation and on CDK7, proteasome, Fyn kinase, tyrosinase, and elastase inhibition. Five compounds (1; 3–6) inhibited proteasome kinase and two compounds (5–6) inhibited CDK7 and Fyn kinase. Osirisyne B (5) was the most active compound with IC50 on FYNB kinase, CDK7 kinase, and proteasome inhibition of 18.44 µM, 9.13 µM, and 0.26 µM, respectively.

AIM: This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic. METHOD: This was an international cohort study of patients undergoing elective resection of colon or rectal cancer without preoperative suspicion of SARS-CoV-2. Centres entered data from their first recorded case of COVID-19 until 19 April 2020. The primary outcome was 30-day mortality. Secondary outcomes included anastomotic leak, postoperative SARS-CoV-2 and a comparison with prepandemic European Society of Coloproctology cohort data. RESULTS: From 2073 patients in 40 countries, 1.3% (27/2073) had a defunctioning stoma and 3.0% (63/2073) had an end stoma instead of an anastomosis only. Thirty-day mortality was 1.8% (38/2073), the incidence of postoperative SARS-CoV-2 was 3.8% (78/2073) and the anastomotic leak rate was 4.9% (86/1738). Mortality was lowest in patients without a leak or SARS-CoV-2 (14/1601, 0.9%) and highest in patients with both a leak and SARS-CoV-2 (5/13, 38.5%). Mortality was independently associated with anastomotic leak (adjusted odds ratio 6.01, 95% confidence interval 2.58-14.06), postoperative SARS-CoV-2 (16.90, 7.86-36.38), male sex (2.46, 1.01-5.93), age >70 years (2.87, 1.32-6.20) and advanced cancer stage (3.43, 1.16-10.21). Compared with prepandemic data, there were fewer anastomotic leaks (4.9% versus 7.7%) and an overall shorter length of stay (6 versus 7 days) but higher mortality (1.7% versus 1.1%). CONCLUSION: Surgeons need to further mitigate against both SARS-CoV-2 and anastomotic leak when offering surgery during current and future COVID-19 waves based on patient, operative and organizational risks.

The spatial and temporal scale of flash flood occurrence provides limited opportunities for observations and measurements using conventional monitoring networks, turning the focus to event-based, post-disaster studies. Post-flood surveys exploit field evidence to make indirect discharge estimations, aiming to improve our understanding of hydrological response dynamics under extreme meteorological forcing. However, discharge estimations are associated with demanding fieldwork aiming to record in small timeframes delicate data and data prone-to-be-lost and achieve the desired accuracy in measurements to minimize various uncertainties of the process. In this work, we explore the potential of unmanned aerial systems (UAS) technology, in combination with the Structure for Motion (SfM) and optical granulometry techniques in peak discharge estimations. We compare the results of the UAS-aided discharge estimations to estimates derived from differential Global Navigation Satellite System (d-GNSS) surveys and hydrologic modelling. The application in the catchment of Soures torrent in Greece, after a catastrophic flood shows that the UAS-aided approach succeeded in determining peak discharge with high accuracy. The technique proved to be particularly effective, providing flexibility in terms of resources and timing, although there are certain limitations to its applicability. The application highlighted important advantages and certain weaknesses of these emerging tools in indirect discharge estimations, which we discuss in detail.

Background:Although several studies that rely on self-determinationtheory have shown the positive interrelations among perceived needsupportive  learning  environment,  needs  satisfaction,  quality  ofmotivation, and desired outcomes in the context of physical education,only few studies have tested so far the full sequence of relations withina single integrated model.Purpose:The main aim of this study was to test whether indeed needssatisfaction and in turn quality of motivation mediate the relations ofneed supportive learning environment to physical activity engagementand intentions.Method:Participants were 1120 Spanish students (49.9% males;Mage =11.70 years;SD= 1.63; range = 10–17 years) from 30 classes out of 13primary and secondary schools.Results:The multilevel path model showed a positive relation ofperceived need-supportive teaching to physical activity engagementand intentions by means of needs satisfaction and autonomousmotivation  and  a  negative  relation  of  perceived  need-thwartingteaching to engagement and intentions by means of needs frustrationand  amotivation.  Although  controlled  motivation  was  found  toassociate with need frustration and need-thwarting teaching it was notassociated with engagement and intentions.Conclusion:the presentfindings suggest that the type of teaching styleemployed by the teachers is decisive to achieve positive consequences inphysical education students.

Recent developments in digital technologies regarding the cultural heritage domain have driven technological trends in comfortable and convenient traveling, by offering interactive and personalized user experiences. The emergence of big data analytics, recommendation systems and personalization techniques have created a smart research field, augmenting cultural heritage visitor’s experience. In this work, a novel, hybrid recommender system for cultural places is proposed, that combines user preference with cultural tourist typologies. Starting with the McKercher typology as a user classification research base, which extracts five categories of heritage tourists out of two variables (cultural centrality and depth of user experience) and using a questionnaire, an enriched cultural tourist typology is developed, where three additional variables governing cultural visitor types are also proposed (frequency of visits, visiting knowledge and duration of the visit). The extracted categories per user are fused in a robust collaborative filtering, matrix factorization-based recommendation algorithm as extra user features. The obtained results on reference data collected from eight cities exhibit an improvement in system performance, thereby indicating the robustness of the presented approach.

Triassic rift-related volcanic rocks outcrop over all mainland Greece, comprising of trachybasalts and basaltic trachyandesites. Relatively immobile to the effects of alteration processes major and trace element abundances classify the volcanics into OIB and E-MORB lavas. They have mainly been distinguished based upon their: i) LREE contents, ii) silica-saturation index (S·I.), iii) Zr/Nb and Nb/Y ratio values; iv) Th, U, and Ta contents v) geotectonic discrimination diagrams. Their geochemistry indicates that most rocks were affected by moderate to extensive differentiation processes, mostly expressed by clinopyroxene fractionation. Some of the OIB and E-MORB volcanics are considered as primitive undersaturated, displaying (low SiO2, Zr/Nb and S.I. values, enhanced CaO/Al2O3 ratios). Calculated average mantle potential temperatures are comparable (1410 °C OIB; 1370 °C E-MORB), with melt fractions estimated at 3–5% for primary OIB magmas and 6–8% for primary E-MORB magmas. An asthenospheric origin is inferred for the OIB lavas, with melting in the garnet stability field (75–95 km; 2.5–3.0 GPa), whereas E-MORB parent magmas were formed with melting in the garnet/spinel (transitional) stability field (55–70 km; 1.8–2.2 GPa). The Hellenic Triassic rift-related lavas were most likely generated and erupted after lithospheric attenuation and extension, followed by subsequent asthenospheric upwelling of the mantle. The high calculated partial melting degrees and the observed thick and voluminous lava formations account for fast-spreading of the Tethys ridge during the Triassic. Temperature results suggest that the Hellenic Triassic rift-related magmas were generated from mantle at ambient temperature, render a mantle plume-based scenario improbable.

Cepheids are pulsating variable stars with a periodic chromospheric response at UV wavelengths close to their minimum radius phase. Recently, an X-ray variable signature was captured in observations during the maximum radius phase. This X-ray emission came as a surprise and is not understood. In this work, we use the modern astrophysical code PLUTO to investigate the effects of pulsations on Cepheid X-ray emission. We run a number of hydrodynamic numerical simulations with a variety of initial and boundary conditions in order to explore the capability of shocks to produce the observed phase-dependent X-ray behavior. Finally, we use the Simulated Observations of X-ray Sources (SOXS) package to create synthetic spectra for each simulation case and link our simulations to observables. We show that, for certain conditions, we can reproduce observed X-ray fluxes at phases 0.4-0.8 when the Cepheid is at maximum radius. Our results span a wide range of mass-loss rates, 2 × 10-13 M☉ yr-1 to 3 × 10-8 M☉ yr-1, and peak X-ray luminosities, 5 × 10-17 erg cm-2 s-1 to 1.4 × 10-12 erg cm-2 s-1. We conclude that Cepheids exhibit two-component emission with (a) shock waves being responsible for the phase-dependent variable emission (phases 0.2-0.6) and (b) a separate quiescent mechanism being the dominant emission mechanism for the remaining phases.

Cepheids are pulsating variable stars with a periodic chromospheric response at UV wavelengths close to their minimum radius phase. Recently, an X-ray variable signature was captured in observations during the maximum radius phase. This X-ray emission came as a surprise and is not understood. In this work, we use the modern astrophysical code PLUTO to investigate the effects of pulsations on Cepheid X-ray emission. We run a number of hydrodynamic numerical simulations with a variety of initial and boundary conditions in order to explore the capability of shocks to produce the observed phase-dependent X-ray behavior. Finally, we use the Simulated Observations of X-ray Sources (SOXS) package to create synthetic spectra for each simulation case and link our simulations to observables. We show that, for certain conditions, we can reproduce observed X-ray fluxes at phases 0.4-0.8 when the Cepheid is at maximum radius. Our results span a wide range of mass-loss rates, 2 × 10-13 M⊙ yr-1 to 3 × 10-8 M⊙ yr-1, and peak X-ray luminosities, 5 × 10-17 erg cm-2 s-1 to 1.4 × 10-12 erg cm-2 s-1. We conclude that Cepheids exhibit two-component emission with (a) shock waves being responsible for the phase-dependent variable emission (phases 0.2-0.6) and (b) a separate quiescent mechanism being the dominant emission mechanism for the remaining phases.

Assessment of the long-term population-level effects of HIV interventions is an ongoing public health challenge. Following the implementation of a Transmission Reduction Intervention Project (TRIP) in Odessa, Ukraine, in 2013-2016, we obtained HIV pol gene sequences and used phylogenetics to identify HIV transmission clusters. We further applied the birth-death skyline model to the sequences from Odessa (n = 275) and Kyiv (n = 92) in order to estimate changes in the epidemic's effective reproductive number (R(e)) and rate of becoming uninfectious (δ). We identified 12 transmission clusters in Odessa; phylogenetic clustering was correlated with younger age and higher average viral load at the time of sampling. Estimated R(e) were similar in Odessa and Kyiv before the initiation of TRIP; R(e) started to decline in 2013 and is now below R(e) = 1 in Odessa (R(e) = 0.4, 95%HPD 0.06-0.75), but not in Kyiv (R(e) = 2.3, 95%HPD 0.2-5.4). Similarly, estimates of δ increased in Odessa after the initiation of TRIP. Given that both cities shared the same HIV prevention programs in 2013-2019, apart from TRIP, the observed changes in transmission parameters are likely attributable to the TRIP intervention. We propose that molecular epidemiology analysis can be used as a post-intervention effectiveness assessment tool.

Numerous studies covering some aspects of SARS-CoV-2 data analyses are being published on a daily basis, including a regularly updated phylogeny on nextstrain.org. Here, we review the difficulties of inferring reliable phylogenies by example of a data snapshot comprising a quality-filtered subset of 8, 736 out of all 16, 453 virus sequences available on May 5, 2020 from gisaid.org. We find that it is difficult to infer a reliable phylogeny on these data due to the large number of sequences in conjunction with the low number of mutations. We further find that rooting the inferred phylogeny with some degree of confidence either via the bat and pangolin outgroups or by applying novel computational methods on the ingroup phylogeny does not appear to be credible. Finally, an automatic classification of the current sequences into sub-classes using the mPTP tool for molecular species delimitation is also, as might be expected, not possible, as the sequences are too closely related. We conclude that, although the application of phylogenetic methods to disentangle the evolution and spread of COVID-19 provides some insight, results of phylogenetic analyses, in particular those conducted under the default settings of current phylogenetic inference tools, as well as downstream analyses on the inferred phylogenies, should be considered and interpreted with extreme caution.

A generalized rigorous Floquet scattering-matrix method for stratified anisotropic optical media, subject to a periodic spatiotemporal modulation, is formulated and implemented. The method is applied for studying an optomagnonic cavity formed by an in-plane magnetized ferrite film, in which a magnetostatic surface spin wave propagates, sandwiched between two nonmagnetic dielectric Bragg mirrors. Our results provide unambiguous evidence that externally incident light, when trapped in a cavity mode, experiences a strongly enhanced interaction with the spin wave due to the increased coupling time, which can give rise to pronounced effects if the appropriate selection rules are fulfilled. By means of systematic calculations we reveal and explain some remarkable features of this interaction, such as formation of spectral gaps, controllable transmission, and the emergence of inelastic diffracted beams, and show that efficient conversion of the optical wave can be achieved by triply resonant inelastic scattering through (multi)magnon absorption and emission processes.

W Ursae Majoris-type binaries belong to the old population of our Galaxy, while their metallicity is close to solar. Their physical properties, kinematics and spatial distribution reflect the properties of their stellar progenitors. This study focuses on the spatial distribution of W UMa's in our solar neighborhood within a 500 pc radius, with a combined astrometric, photometric and spectroscopic determination of their stellar parameters. The sample is carefully selected, in order to fulfill certain criteria, and has well defined metallicity and distance parameters. H-R diagram, as well as similar correlation plots (mass-radius and mass-luminosity), show that the primary (more massive) components in such systems are located close or below the ZAMS region, while secondary components seem to be evolved, as a result of their common envelope geometry. Some prominent outliers are carefully examined in order to judge the environmental properties and evolution in certain locations of the Milky Way. It is found that metallicity is not correlated with distance, but there is a weak correlation between metallicity [M/H] and evolution state, as it is expressed by the location of the systems in the H-R diagram, the type of binary (A or W), and temperature.

Marathon Lake is an artificial reservoir with great environmental, ecological, social, and economic significance because it was the main source of water for Athens, the capital of Greece, for many years. The present study details the first attempt to map sedimentation in Marathon Lake in detail, using bathymetric mapping and soil erosion field surveying of the torrent watershed areas. First, the results of a bathymetric survey carried out in 2011 were compared with topographic maps that pre-date the construction of the dam. Based on this comparison, an estimated 8.34 hm3 of sediment have been deposited in the 80 years since the dam’s construction. In the current survey, the Revised Universal Soil Loss Equation (RUSLE) was used to estimate soil loss in the watershed area of the streams that end in Marathon Lake. The estimated value from the RUSLE was substantially lower (3.02 hm3) than that calculated in the bathymetric survey.

© 2019, Hellenic Endocrine Society. Premature ovarian insufficiency (POI) is typically diagnosed when amenorrhea is combined with high gonadotrophins and hypoestrogenemia in a woman under 40 years of age, although, more rarely, POI can develop in adolescence and present with delayed puberty or amenorrhea, depending on the timing of follicular depletion or insult to the ovary. In a proportion of girls, the diagnosis may be made at an early stage of POI, presenting with abnormal uterine bleeding, when some follicular function is still retained. The natural history of POI in this group of patients is not clear; however, they could represent a subgroup with a unique opportunity for early intervention and thus the provision of fertility preservation options. While the etiology of POI in a large number of girls remains unknown, a growing number will be identified as carriers of genetic mutations, offering clinicians a yet greater opportunity to provide genetic counseling to other female family members. The aim of this review is to provide information regarding the etiology, diagnosis, and treatment of POI in adolescents while detailing the new options for fertility preservation when POI is diagnosed at an early stage.

OBJECTIVE: We aim to show the feasibility of using an integrated prevention and care continuum (PCC) model as a complete and improved tool for HIV control measurement and programming. Alignment of prevention and care continua is essential to further improve health outcomes and minimize HIV transmission risk. DESIGN: Cross-sectional study. METHODS: Data from 977 persons who inject drugs (PWID) collected in 2011-2016 in Tallinn, Estonia, were used to construct an HIV PCC for PWID, stratified by risk for acquiring or transmitting HIV infection and by coverage of combined interventions. We also estimated the average protective effect of current levels of intervention provision. RESULTS: 74.4%, 20.3% and 35.2% of PWID were currently using needle and syringe programmes (NSP), drug treatment and HIV testing, respectively. 51.1% of current PWID were HIV seropositive and of those 62.5% were currently on ART and 19.0% were virally suppressed. Across the PCC, individuals moved between categories of being aware and ever using drug treatment (resulting in -50% "leakage"); from ever having used to currently using drug treatment (-59%); between "ever testing" and "current (continuous) testing" (-62%); and from self-reported antiretroviral therapy (ART) adherence to viral suppression (-70%). Use of prevention services was higher among those at risk of transmission (HIV positive). The overall reduction in acquisition risk among HIV-negative PWID was 77.7% (95% CrI 67.8-84.5%), estimated by the modelled protective effects of current levels of NSP, drug treatment and ART compared to none of these services. CONCLUSIONS: Our findings suggest that developing a cohesive model for HIV prevention and treatment is feasible and reflects the bi-directional relationships between prevention and care. The integrated continuum model indicates the major factors which may predict the epidemic course and control response.

INTRODUCTION: Both stable chronic obstructive pulmonary disease (COPD) and acute exacerbations represent leading causes of death, disability and healthcare expenditure. They are complex, heterogeneous and their mechanisms are poorly understood. The role of respiratory viruses has been studied extensively but is still not adequately addressed clinically. Through a rigorous evidence update, we aim to define the prevalence and clinical burden of the different respiratory viruses in stable COPD and exacerbations, and to investigate whether viral load of usual respiratory viruses could be used for diagnosis of exacerbations triggered by viruses, which are currently not diagnosed or treated aetiologically. METHODS AND ANALYSIS: Based on a prospectively registered protocol, we will systematically review the literature using standard methods recommended by the Cochrane Collaboration and the Grading of Recommendations Assessment, Development and Evaluation working group. We will search Medline/PubMed, Excerpta Medica dataBASE (EMBASE), the Cochrane Library, the WHO's Clinical Trials Registry and the proceedings of relevant international conferences on 2 March 2020. We will evaluate: (A) the prevalence of respiratory viruses in stable COPD and exacerbations, (B) differences in the viral loads of respiratory viruses in stable COPD vs exacerbations, to explore whether the viral load of prevalent respiratory viruses could be used as a diagnostic biomarker for exacerbations triggered by viruses and (C) the association between the presence of respiratory viruses and clinical outcomes in stable COPD and in exacerbations. ETHICS AND DISSEMINATION: Ethics approval is not required since no primary data will be collected. Our findings will be presented in national and international scientific conferences and will be published in peer reviewed journals. Respiratory viruses currently represent a lost opportunity to improve the outcomes of both stable COPD and exacerbations. Our work aspires to 'demystify' the prevalence and clinical burden of viruses in stable COPD and exacerbations and to promote clinical and translational research. PROSPERO REGISTRATION NUMBER: CRD42019147658.

The current paper emphasizes on the debate referring to how historical case studies are processed in social sciences and humanities and which limitations have to be surpassed towards a clear-cut descriptive analysis. Systemic Geopolitical Analysis does offer the necessary set of methodological tools contributing to a reading of causes and effects without any deontological bias. To this aim, it uses a sequence of methodological stages for the description, the standardization, the terminology definition, the synthesis and finally, the draw of conclusions named as “sample of redistributions of power”. This last part is essentially followed by the geostrategic synthesis part; the descriptive and clearly scientific in which the geopolitical framework is given is followed by the subjective geostrategic one in which the challenges, dilemmas, threats and opportunities on behalf of a certain actor are presented. Based on this legacy, processing historical case studies is made with a clear distinction between objectivity and subjectivity or, in other words, between science with ontological reference and geostrategic recommendations. This paper replies to the epistemological legacy Systemic Geopolitical Analysis relying on as well as its core theoretical and methodological contribution.

Neocortex development depends on neural stem cell proliferation, cell differentiation, neurogenesis, and neuronal migration. Cytoskeletal regulation is critical for all these processes, but the underlying mechanisms are only poorly understood. We previously implicated the cytoskeletal regulator profilin1 in cerebellar granule neuron migration. Since we found profilin1 expressed throughout mouse neocortex development, we here tested the hypothesis that profilin1 is crucial for neocortex development. We found no evidence for impaired neuron migration or layering in the neocortex of profilin1 mutant mice. However, proliferative activity at basal positions was doubled in the mutant neocortex during mid-neurogenesis, with a drastic and specific increase in basal Pax6+ cells indicative for elevated numbers of basal radial glia (bRG). This was accompanied by transiently increased neurogenesis and associated with mild invaginations resembling rudimentary neocortex folds. Our data are in line with a model in which profilin1-dependent actin assembly controls division of apical radial glia (aRG) and thereby the fate of their progenies. Via this mechanism, profilin1 restricts cell delamination from the ventricular surface and, hence, bRG production and thereby controls neocortex development in mice. Our data support the radial cone hypothesis" claiming that elevated bRG number causes neocortex folds.

The origin of high-energy emission in blazars jets (I.e., leptonic versus hadronic) has been a longstanding matter of debate. Here, we focus on one variant of hadronic models where proton synchrotron radiation accounts for the observed steady γ-ray blazar emission. Using analytical methods, we derive the minimum jet power ( ${P}_{j,\min }$ ) for the largest blazar sample analyzed to date (145 sources), taking into account uncertainties of observables and jet's physical parameters. We compare ${P}_{j,\min }$ against three characteristic energy estimators for accreting systems, I.e., the Eddington luminosity, the accretion disk luminosity, and the power of the Blandford-Znajek process, and find that ${P}_{j,\min }$ is about 2 orders of magnitude higher than all energetic estimators for the majority of our sample. The derived magnetic field strengths in the emission region require either large amplification of the jet's magnetic field (factor of 30) or place the γ-ray production site at sub-pc scales. The expected neutrino emission peaks at ∼0.1-10 EeV, with typical peak neutrino fluxes ∼10-4 times lower than the peak γ-ray fluxes. We conclude that if relativistic hadrons are present in blazar jets, they can only produce a radiatively subdominant component of the overall spectral energy distribution of the blazar's steady emission.

RATIONALE: Νeurosteroids, like dehydroepiandrosterone (DHEA), play an important role in neurodegeneration and neural protection, but they are metabolized in androgens, estrogens, or other active metabolites. A newly developed synthetic DHEA analog, BNN27 ((20R)-3β,21-dihydroxy-17R,20-epoxy-5-pregnene), exerts neurotrophic and neuroprotective actions without estrogenic or androgenic effects. OBJECTIVES: This study aimed to investigate potential anxiolytic or antidepressant properties of BNN27. METHODS: Male and female adult Wistar rats were treated with BNN27 (10, 30, or 90 mg/kg, i.p.) and subjected to behavioral tests measuring locomotion, exploration, and "depressive-like" behavior (open field, light/dark box, hole-board, and forced swim tests). The hippocampus and prefrontal cortex were collected for glutamate and GABA measurements, and trunk blood was collected for gonadal hormone analysis. RESULTS: Acute high-dose BNN27 reduced locomotion and exploratory behavior in both sexes. Intermediate acute doses (30 mg/kg) of BNN27 reduced exploration and testosterone levels only in males, and enhanced progesterone levels in both sexes. Notably, with the present design, BNN27 had neither anxiolytic nor antidepressant effects and did not affect estrogen levels. Interestingly, acute administration of a low BNN27 dose (10 mg/kg) increased glutamate turnover, GABA, and glutamine levels in the hippocampus. The same dose also enhanced glutamate levels in the prefrontal cortex of males only. Sex differences were apparent in the basal levels of behavioral, hormonal, and neurochemical parameters, as expected. CONCLUSIONS: BNN27 affects locomotion, progesterone, and testosterone levels, as well as the glutamatergic and GABAergic systems of the hippocampus and prefrontal cortex in a sex-dependent way.

The knapsack problem is a problem in combinatorial optimization, and in many such problems, exhaustive search is not tractable. In this paper, we describe and analyze the randomized time-varying knapsack problem (RTVKP) as a time-varying integer linear programming (TV-ILP) problem. In this way, we present the on-line solution to the RTVKP combinatorial optimization problem and highlight the restrictions of static methods. In addition, the RTVKP is applied in the field of finance and converted into a portfolio insurance problem. Our methodology is confirmed by simulation tests in real-world data sets, in order to explain being an excellent alternative to traditional approaches.

The organization of the mitochondrial electron transport chain proteins into supercomplexes (SCs) is now undisputed; however, their assembly process, or the role of differential expression isoforms, remain to be determined. In Saccharomyces cerevisiae, cytochrome c oxidase (CIV) forms SCs of varying stoichiometry with cytochrome bc(1) (CIII). Recent studies have revealed, in normoxic growth conditions, an interface made exclusively by Cox5A, the only yeast respiratory protein that exists as one of two isoforms depending on oxygen levels. Here we present the cryo-EM structures of the III(2)-IV(1) and III(2)-IV(2) SCs containing the hypoxic isoform Cox5B solved at 3.4 and 2.8 A, respectively. We show that the change of isoform does not affect SC formation or activity, and that SC stoichiometry is dictated by the level of CIII/CIV biosynthesis. Comparison of the CIV(5B)- and CIV(5A)-containing SC structures highlighted few differences, found mainly in the region of Cox5. Additional density was revealed in all SCs, independent of the CIV isoform, in a pocket formed by Cox1, Cox3, Cox12, and Cox13, away from the CIII-CIV interface. In the CIV(5B)-containing hypoxic SCs, this could be confidently assigned to the hypoxia-induced gene 1 (Hig1) type 2 protein Rcf2. With conserved residues in mammalian Hig1 proteins and Cox3/Cox12/Cox13 orthologs, we propose that Hig1 type 2 proteins are stoichiometric subunits of CIV, at least when within a III-IV SC.

The joint detection of GW170817/GRB 170817 confirmed the long-standing theory that binary neutron star mergers produce short gamma-ray burst (sGRB) jets that can successfully break out of the surrounding ejecta. At the same time, the association with a kilonova provided unprecedented information regarding the physical properties (such as masses and velocities) of the different ejecta constituents. Combining this knowledge with the observed luminosities and durations of cosmological sGRBs detected by the Burst Alert Telescope onboard the Neil Gehrels Swift Observatory, we revisit the breakout conditions of sGRB jets. Assuming self-collimation of sGRB jets does not play a critical role, we find that the time interval between the binary merger and the launch of a typical sGRB jet is $\lesssim 0.1\,{\rm{s}}$ . We also show that for a fraction of at least $\sim 30 \% $ of sGRBs, the usually adopted assumption of static ejecta is inconsistent with observations, even if the polar ejecta mass is an order of magnitude smaller than that in GRB 170817. Our results disfavor magnetar central engines for powering cosmological sGRBs, limit the amount of energy deposited in the cocoon prior to breakout, and suggest that the observed delay of ∼1.7 s in GW170817/GRB 170817 between the gravitational wave and gamma-ray signals is likely dominated by the propagation time of the jet to the gamma-ray production site.

 

Maintenance of synaptic homeostasis is a challenging task, due to the intricate spatial organization and intense activity of synapses. Typically, synapses are located far away from the neuronal cell body, where they orchestrate neuronal signalling and communication, through neurotransmitter release. Stationary mitochondria provide energy required for synaptic vesicle cycling, and preserve ionic balance by buffering intercellular calcium at synapses. Thus, synaptic homeostasis is critically dependent on proper mitochondrial function. Indeed, defective mitochondrial metabolism is a common feature of several neurodegenerative and psychiatric disorders, including Alzheimer's disease (AD), Parkinson's disease (PD), bipolar disorders and schizophrenia among others, which are also accompanied by excessive synaptic abnormalities. Specialized and compartmentalized quality control mechanisms have evolved to restore and maintain synaptic energy metabolism. Here, we survey recent advances towards the elucidation of the pivotal role of mitochondria in neurotransmission and implicating mitophagy in the maintenance of synaptic homeostasis during ageing.

AbsractPurposeTo demonstrate that oral drug absorption is terminated in finite time. To develop models based on biopharmaceutical/physiological and finite absorption time concepts.MethodsThe models are based on i) the passive drug diffusion mechanism under the sink conditions principle ii) the rate limiting role of the drug's properties solubility and permeability and iii) the relevant restrictions associated with the gastrointestinal transit times of drug in the stomach, the small intestines and the colon. Two input functions of constant rate are considered for the absorption of drug from i) the stomach/small intestines with an upper limit of 5 h and ii) the colon with an upper limit of 30 h. Branched differential equations were written for the time course of drug in the body.ResultsSimulations were performed using different scenarios, assuming a variety of drug properties and limited or non-existent absorption from the colon. Literature oral data of cephradine, ibuprofen, flurbiprofen and itraconazole were analyzed. For all drugs examined, nice fittings of the branched differential equations to the experimental data were observed.ConclusionsFor all drugs the absorption process was terminated in the small intestine. The meaning of partial AUCs, Cmax, tmax are questioned. Applications of these models to IVIVC are anticipated.

We present the results obtained from the analysis of high-mass X-ray binary pulsar 4U 1909+07 using NuSTAR and Astrosat observations in July 2015 and 2017, respectively. X-ray pulsations at ≈604 s are clearly detected in our study. Based on the long-term spin-frequency evolution, the source is found to spun-up in the last 17 yr. We observed a strongly energy-dependent pulse profile that evolved from a complex broad structure in soft X-rays into a profile with a narrow emission peak followed by a plateau in energy ranges above 20 keV. This behaviour ensured a positive correlation between the energy and pulse fraction. The pulse profile morphology and its energy evolution are almost similar during both the observations, suggesting a persistent emission geometry of the pulsar over time. The broad-band energy spectrum of the pulsar is approximated by an absorbed high-energy exponential cut-off power-law model with iron emission lines. In contrast to the previous report, we found no statistical evidence for the presence of cyclotron absorption features in the X-ray spectra. We performed phase-resolved spectroscopy using data from the NuSTAR observation. Our results showed a clear signature of absorbing material at certain pulse phases of the pulsar. These findings are discussed in terms of stellar wind distribution and its effect on the beam geometry of this wind-fed accreting neutron star. We also reviewed the subsonic quasi-spherical accretion theory and its implication on the magnetic field of 4U 1909+07 depending on the global spin-up rate.

Hadronic supercriticalities are radiative instabilities that appear when large amounts of energy are stored in relativistic protons. When the proton energy density exceeds some critical value, a runaway process is initiated resulting in the explosive transfer of the proton energy into electron-positron pairs and radiation. The runaway also leads to an increase of the radiative efficiency, namely the ratio of the photon luminosity to the injected proton luminosity. We perform a comprehensive study of the parameter space by investigating the onset of hadronic supercriticalities for a wide range of source parameters (I.e. magnetic field strengths of 1 G-100 kG and radii of 1011-1016 cm) and maximum proton Lorentz factors (103-109). We show that supercriticalities are possible for the whole range of source parameters related to compact astrophysical sources, like gamma-ray bursts and cores and jets of active galactic nuclei. We also provide an in-depth look at the physical mechanisms of hadronic supercriticalities and show that magnetized relativistic plasmas are excellent examples of non-linear dynamical systems in high-energy astrophysics.

Hadronic supercriticalities are radiative instabilities that appear when large amounts of energy are stored in relativistic protons. When the proton energy density exceeds some critical value, a runaway process is initiated resulting in the explosive transfer of the proton energy into electron-positron pairs and radiation. The runaway also leads to an increase of the radiative efficiency, namely the ratio of the photon luminosity to the injected proton luminosity. We perform a comprehensive study of the parameter space by investigating the onset of hadronic supercriticalities for a wide range of source parameters (I.e. magnetic field strengths of 1 G-100 kG and radii of 1011-1016 cm) and maximum proton Lorentz factors (103-109). We show that supercriticalities are possible for the whole range of source parameters related to compact astrophysical sources, like gamma-ray bursts and cores and jets of active galactic nuclei. We also provide an in-depth look at the physical mechanisms of hadronic supercriticalities and show that magnetized relativistic plasmas are excellent examples of non-linear dynamical systems in high-energy astrophysics.

In the course of a primary screening of 614 microbial actinomycete extracts for the discovery of tyrosinase inhibitors, the EtOAc extract of the fermentation broth of the strain Streptomyces sp. CA-129531 isolated from a Martinique sample, exhibited in cell free and cell-based assays the most promising activity (IC50 value of 63 $μ$g/mL). Scaled-up production in a bioreactor led to the isolation of one new trichostatic acid analogue, namely trichostatic acid B (1), along with six known trichostatin derivatives (2-7), four diketopiperazines (8-11), two butyrolactones (12-13) and one hydroxamic acid siderophore (14). Among them, trichostatin A (4) showed six times stronger anti-tyrosinase activity (IC50 2.18 $μ$Μ) than kojic acid (IC50 14.07 $μ$Μ) used as a positive control. Deoxytrichostatin A (6) displayed also strong inhibitory activity against tyrosinase (IC50 19.18 $μ$Μ). Trichostatin A production in bioreactor started together with the exponential phase of growth (day 4) and the maximum concentration was reached at day 9 (2.67 ± 0.13 $μ$g/mL). Despite the cytotoxicity of some individual components, no cytotoxic effect on HepG2, A2058, A549, MCF-7 and MIA PaCa-2 cell lines was found for the EtOAc extract (IC50 {\textgreater} 2.84 mg/mL), while it found no cytotoxic against BG fibroblasts at the concentrations were it exerted whitening effect, reassuring its safety and great tyrosinase inhibitory potential.

The tectonic setting of western Peloponnese and central Ionian Islands, Greece, is characterized by the subduction of the oceanic African plate beneath the Aegean micro-plate. The transition from subduction to continental collision in northwestern Greece is accommodated by the right-lateral Cephalonia transform fault. In this work, we exploit the recordings of a temporary seismic network composed of 15 stations operating from July 2016 until May 2017 to investigate the complex deformation of this region. Our local network fills in a major observational gap in one of the most tectonically active regions of the Hellenic arc. We detected and located more than 1200 local earthquakes and constrained five 1D optimum local velocity models. The relocated seismicity (including the aftershock sequence that followed the October 2018 Mw 6.7 earthquake offshore Zakynthos) and associated focal mechanisms constrained for the major earthquakes point out a complex crustal deformation. We propose a clockwise rotation of the Ionian Akarnania Block accommodated by major marginal strike-slip fault zones that appear segmented along their strike. Additionally, left-lateral motion is observed on the Kyllini-Cephalonia fault along a north-west direction. Finally, the seismicity recorded in north Cephalonia (offshore Myrtos and Fiskardo) suggests that the Cephalonia transform fault is a large deformation zone where secondary WNW-striking sinistral strike-slip faults occur.

Due to early implementation of public health measures, Greece had low number of SARS-CoV-2 infections and COVID-19 severe incidents in hospitalized patients. The National and Kapodistrian University of Athens (ΝΚUA), especially its health-care/medical personnel, has been actively involved in the first line of state responses to COVID-19. To estimate the prevalence of antibodies (Igs) against SARS-CoV-2 among NKUA members, we designed a five consecutive monthly serosurvey among randomly selected NKUA consenting volunteers. Here, we present the results from the first 2500 plasma samples collected during June-July 2020. Twenty-five donors were tested positive for anti-SARS-CoV-2 Igs; thus, the overall seroprevalence was 1.00%. The weighted overall seroprevalence was 0.93% (95% CI: 0.27, 2.09) and varied between males [1.05% (95% CI: 0.18, 2.92)] and females [0.84% (95% CI: 0.13, 2.49)], age-groups and different categories (higher in participants from the School of Health Sciences and in scientific affiliates/faculty members/laboratory assistants), but no statistical differences were detected. Although focused on the specific population of NKUA members, our study shows that the prevalence of anti-SARS-CoV-2 Igs for the period June-July 2020 remained low and provides knowledge of public health importance for the NKUA members. Given that approximately one in three infections was asymptomatic, continuous monitoring of the progression of the pandemic by assessing Ig seroprevalence is needed.

Prevalence and symptoms of most psychiatric and neurological disorders differ in men and women and there is substantial evidence that their neurobiological basis and treatment also differ by sex. This special issue sought to bring together a series of empirical papers and targeted reviews to highlight the diverse impact of sex in neuroscience and neuropsychopharmacology. This special issue emphasizes the diverse impact of sex in neuroscience and neuropsychopharmacology, including 9 review papers and 17 research articles highlighting investigation in different species (zebrafish, mice, rats, and humans). Each contribution covers scientific topics that overlap with genetics, endocrinology, cognition, behavioral neuroscience, neurology, and pharmacology. Investigating the extent to which sex differences can impact the brain and behavior is key to moving forward in neuroscience research.

BACKGROUND & AIMS: The incidence of hepatocellular carcinoma (HCC) was recently reported to be lower in Asian chronic hepatitis B (CHB) patients treated with tenofovir disoproxil fumarate (TDF) than entecavir (ETV), but this finding remains controversial. We assessed whether there was a difference between ETV and TDF treated patients of the well monitored, multicenter European PAGE-B cohort in the HCC incidence and other patient outcomes. METHODS: We included 1935 Caucasians with CHB, with or without compensated cirrhosis, treated with ETV (n=772) or TDF (n=1163) monotherapy. Mean follow-up has been 7.1+/-3.0 years from ETV/TDF onset. RESULTS: The 5-year cumulative HCC incidence was 5.4% in ETV and 6.0% in TDF treated patients (log-rank, P=0.321) without significant difference in any patient subgroup [with or without cirrhosis, naive or experienced to oral antiviral(s) (total, with or without cirrhosis)]. In multivariable Cox regression analyses, the hazard of HCC was similar between ETV and TDF treated patients after adjustment for several HCC risk factors. ETV and TDF treated patients had similar rates of on-therapy biochemical and virological remission, HBsAg loss, liver transplantation and/or death. Elastographic reversion of cirrhosis at year 5 (liver stiffness <12 kPa) was observed in 245/347 (70.6%) patients with pretreatment cirrhosis being more frequent in TDF than ETV treated patients (73.8% vs 61.5%, P=0.038). CONCLUSION: In Caucasian CHB patients, with or without cirrhosis, ETV and TDF long-term monotherapy is associated with similar HCC risk and rates of biochemical and virological remission, HBsAg loss and liver transplantation or death, but TDF seems to result in more frequent elastographic reversion of cirrhosis at year 5.

In the interconfessional theological dialogue between the Orthodox and the Roman-Catholic Church, there has been much discussion about the famous passage 16:16–19 of Matthew’s Gospel. However, not much attention has been paid to the testimonies of other New Testament books about the Apostle Peter’s person, work, and historical impact. This paper examines the narrative character of Simon Peter in John’s Gospel to contribute to a more comprehensive understanding of the great apostle’s historical significance in early Christianity. In our analysis, we make use of the narrative-critical method focusing on the comparison between Simon Peter and the Beloved Disciple. This approach opens a window to how the Johannine community evaluated Peter’s person and significance at the time of the composition of the Fourth Gospel, and, thus, helps us better understand the biblical foundations of the theological debate on the papal office.

Using the core-EP inverse, we obtain the unique solution to the constrained matrix minimization problem in the Euclidean norm: $$\mathrm{Minimize }\ \Vert Mx-b\Vert _2$$Minimize‖Mx-b‖2, subject to the constraint $$x\in \mathcal{R}(M^k),$$x∈R(Mk),where $$M\in {\mathbb {C}}^{n\times n}$$M∈Cn×n, $$k=\mathrm {Ind}(M)$$k=Ind(M)and $$b\in {\mathbb {C}}^n$$b∈Cn. This problem reduces to well-known results for complex matrices of index one and for nonsingular complex matrices. We present two kinds of Cramer’s rules for finding unique solution to the above mentioned problem, applying one well-known expression and one new expression for core-EP inverse. Also, we consider a corresponding constrained matrix approximation problem and its Cramer’s rules based on the W-weighted core-EP inverse. Numerical comparison with classical strategies for solving the least squares problems with linear equality constraints is presented. Particular cases of the considered constrained optimization problem are considered as well as application in solving constrained matrix equations.

In ELT contexts, the concept of ELF awareness has been proposed as a means of developing the skills, strategies, and overall outlook that learners require to competently participate in ELF interactions. Depending on the teaching context, this can be a demanding process. We discuss the ELF-aware instructional interventions carried out by two practitioners working in high-stakes exam preparation contexts in Greece. These contexts are predominantly Standard English oriented. The interventions described an attempt to put into practice the principles of ELF-aware pedagogy, namely awareness of language and language use, awareness of instructional practice, and awareness of learning. The innovative aspect of these interventions is that they do not run contrary to the curriculum of these high-stakes exam preparation classes. On the contrary, they complement the courseware used in these contexts with authentic audiovisual materials and original metalinguistic activities that boost learners’ self-confidence as ELF speakers and as candidates of these exams.

The purpose of this paper is to present a new method for early detection of forest fires, especially in forest zones prone to fires using microwave remote sensing and information-modeling tools. A decision-making system is developed as a tool for operational coupled analysis of modeling results and remote sensing data. The main operating structure of this system has blocks that calculate the moisture of forest canopy, the soil-litter layer, and the forest physical temperature using the observed brightness temperature provided by the flying platform IL-18 equipped with passive microwave radiometers of 1.43, 13.3 and 37.5 GHz frequencies. The hydrological parameters of the forest are assessed with both a developed regional hydrological model and remote sensing observations. The hydrological model allows for the detection of fire-prone zones that are subject to remote sensing when modeling results are corrected and thermal temperatures are evaluated. An approach for the real time forest fires classification via daytime remote sensing observations is proposed. The relative theoretical and experimental results presented here have allowed us to use a new approach to forests monitoring during periods of potential fire. A decision-making algorithm is presented that aims at analyzing data flows from radiometers located on the remote sensing platform to calculate the probability of forest fire occurring in geographical pixels. As case study, the state of forest fires that occurred in Siberia in 2019 using microwave remote sensing measurements conducted by a flying IL-18 laboratory is presented. This remote sensing platform is equipped with optical and microwave tools that allow the optical and microwave images of the observed forest areas. The main operating frequencies of microwave radiometers are 1.43, 13.3 and 37.5 GHz. Microwave radiometers provide data on water content in the forest canopy and on litter and physical temperatures. Based on the long-term measurements made in Siberia, the possible improvement of the proposed decision-making system for future relevant studies is discussed in detail. The basic idea of cost-effective monitoring of forested areas consists of a two-stage exploration of fire risk zones. The first monitoring stage is performed using the hydrological model of the study area to identify low moisture areas of the forest canopy and litter. The second stage of monitoring is conducted using the remote sensing platform only in the local fire-dangerous areas in order to more precisely identify the areas prone to fire and to detect and diagnose real burning zones. The developed algorithm allows the calculation of physical temperatures and the detection of temperature anomalies based on measured brightness temperatures. Finally, the spatial distribution of the probability of forest fire occurrence is given as an example of the decision-making system along with a comparison of this distribution with the satellite images provided by the EOSDIS Land data.

Ο Λεωνίδας Αρνιώτης, γεννημένος το 1862 στην Σπάρτη Λακωνίας, υπήρξε εξέχουσα προσωπικότητα, καλλιτέχνης των παραστατικών τεχνών του τέλους του 19ου και των αρχών του 20ου αι. με εθνική αλλά κυρίως διεθνή παρουσία. Στο άρθρο περιγράφεται η άγνωστη καλλιτεχνική πορεία του Λεωνίδα Αρνιώτη στις Η.Π.Α. αλλά και σε μεγάλες ευρωπαϊκές πρωτεύουσες: Παρίσι, Λονδίνο, Ρώμη, Βερολίνο, Βρυξέλλες κα. Ο Αρνιώτης υπήρξε ιπποδαμαστής, jockey, ακροβάτης επί ίππου, πυγμάχος, πυγμάχος επί ίππου, θιασάρχης, θεατρώνης, στιχουργός, συγγραφέας επιθεωρήσεων, θεατρικών έργων, επιστημονικών μελετών, πιλότος αεροπλάνων αλλά κυρίως ένας από τους διασημότερους εκπαιδευτές ζώων παγκοσμίως. Στα τέλη του 19ου αι. συνοδευόμενος από τη σύζυγό του Μαίρη και τον πολυάρθμο θίασο τετραπόδων σκύλων και γάτων πραγματοποίησε διετή περιοδεία στις Η.Π.Α. και υπήρξε ο πρώτος Έλληνας καλλιτέχνης στην άλλη πλευρά του Ατλαντικού με σταθερή και εκτεταμένη παρουσία. Εμπνευστής αλλαγών, με πολυδύναμες και διαισθητικές ικανότητες, εξέφρασε με ενάργεια το πνεύμα της εποχής, της μετάβασης από το 19ο στον 20ο αι. και αποτέλεσε καθοριστική προσωπικότητα σε σχέση με την εισαγωγή παγκόσμιων παραστατικών τάσεων στην αθηναϊκή σκηνή.

Introduction. In volleyball, setting is a critical skill from a technical and tactical point of view, as it affects attack directly: the better the quality of the setter’s performance, the more excellent attack actions are carried out by men and women attackers. Aim of Study. This study aimed to assess the spatial and temporal characteristics of the setting choices made by junior male volleyball setters and their performance concerning the game complex per match rotation. Material and Methods. A three-member group of experienced coaches assessed the setting zones choices, the setting tempo, and the performance of junior male setters from 20 volleyball games of teams competing in the final phase of the 2016 Greek Junior Championship. A five-level ordinal scale was used to evaluate the setting. The test of independence for the categorical variables was carried out using the chi-square test (χ2 ). Following the overall independence test, the difference in proportions among all levels of variables was tested. Results. Results showed that zone 4 was the junior setters’ first choice irrespective of the game complex. More detailed, in Complex II, the most preferable setting zones were 4 and 6, while zone 3 was the primary selection in Complex I. The setting in the first tempo was the most favorite option in Complex I, although second slow tempo was the most frequently used setting option in Complex II. As for the quality of the setting, the dominant value for both complexes was quality level 2. Conclusions. In conclusion, the junior male setters directed the ball mainly to position 4 by using the slow 2nd tempo settings irrespective of the game rotation. Moreover, they showed a higher proportion of excellent setting actions and used fast settings (first tempo) more frequently in Complex I than in Complex II. KEYWORDS:

Between May 2017 and November 2018, Greece has experienced a severe measles outbreak with a total of 3258 cases reported, after reaching its goal of eliminating measles since 2014-2015. In this study, we aimed to investigate the origin and the dispersal patterns of the measles strains that circulated in Greece during this outbreak and to identify possible transmission patterns of measles virus (MeV) in the country. Of the 832 measles suspect cases referred to the National Measles and Rubella Reference Laboratory for MeV RNA detection, 131 randomly selected positive samples, representative of the temporal and spatial distribution of the laboratory-confirmed measles cases in Greece, were processed for genotypic identification by an RT-PCR amplification of a 598 bp fragment containing the 450 bp hypervariable region of the measles virus N gene. Phylogenetic analysis was carried out by the approximate maximum likelihood method (ML) under the generalized time-reversible (GTR + cat) model. All samples analyzed were found to belong to genotype B3. Comparative analysis with other European and reference measles strains revealed three separate major clusters and other multiple viruses circulating simultaneously in Greece. They were all isolated from three main community groups, Greek-Roma children, non-minority Greek nationals and immigrants/refugees, a finding that is in accordance with what was also observed in the last two measles outbreaks in 2005-2006 and 2010-2011. Notably, for one of the three clusters, no similarity was detected with previously reported prototype strains. Our results indicate the need for a more intensive vaccination program against measles amongst minority populations and in refugee hot-spots as well as the importance of molecular surveillance as a tool for monitoring measles outbreaks.

We report a thorough theoretical investigation of magnon-assisted photon transitions in magnetic garnet micron-sized spheres, which operate as optomagnonic resonators. In this case, matching the intraband splitting of optical Mie modes, induced by particle magnetization, to the eigenfrequency of the uniform-precession spin wave, high-efficiency triply resonant optical transitions between these modes, through respective emission or absorption of a cavity magnon, are enabled. By means of rigorous full electrodynamic computations, supported by corresponding approximate analytical calculations, we provide compelling evidence of greatly increased optomagnonic interaction, compared to that in similar processes between whispering gallery modes of corresponding submillimeter spheres, due to the reduced magnon mode volume. We explain the underlying mechanisms to a degree that goes beyond existing interpretation, invoking group theory to derive general selection rules and highlighting the role of the photon spin as the key property for maximizing the respective coupling strength.

We report a thorough theoretical investigation of magnon-assisted photon transitions in magnetic garnet micron-sized spheres, which operate as optomagnonic resonators. In this case, matching the intraband splitting of optical Mie modes, induced by particle magnetization, to the eigenfrequency of the uniform-precession spin wave, high-efficiency triply resonant optical transitions between these modes, through respective emission or absorption of a cavity magnon, are enabled. By means of rigorous full electrodynamic computations, supported by corresponding approximate analytical calculations, we provide compelling evidence of greatly increased optomagnonic interaction, compared to that in similar processes between whispering gallery modes of corresponding submillimeter spheres, due to the reduced magnon mode volume. We explain the underlying mechanisms to a degree that goes beyond existing interpretation, invoking group theory to derive general selection rules and highlighting the role of the photon spin as the key property for maximizing the respective coupling strength. © 2020 American Physical Society.

Binary black hole (BH) central engine description for the unique blazar OJ 287 predicted that the next secondary BH impact-induced bremsstrahlung flare should peak on 2019 July 31. This prediction was based on detailed general relativistic modeling of the secondary BH trajectory around the primary BH and its accretion disk. The expected flare was termed the Eddington flare to commemorate the centennial celebrations of now-famous solar eclipse observations to test general relativity by Sir Arthur Eddington. We analyze the multi-epoch Spitzer observations of the expected flare between 2019 July 31 and 2019 September 6, as well as baseline observations during 2019 February-March. Observed Spitzer flux density variations during the predicted outburst time display a strong similarity with the observed optical pericenter flare from OJ 287 during 2007 September. The predicted flare appears comparable to the 2007 flare after subtracting the expected higher base-level Spitzer flux densities at 3.55 and 4.49 μm compared to the optical R-band. Comparing the 2019 and 2007 outburst lightcurves and the previously calculated predictions, we find that the Eddington flare arrived within 4 hr of the predicted time. Our Spitzer observations are well consistent with the presence of a nano-Hertz gravitational-wave emitting spinning massive binary BH that inspirals along a general relativistic eccentric orbit in OJ 287. These multi-epoch Spitzer observations provide a parametric constraint on the celebrated BH no-hair theorem.

In the course of the first all-sky survey (eRASS1), the eROSITA instrument on board the Russian/German Spektrum-Roentgen-Gamma (SRG) mission started scanning the Small Magellanic Cloud (SMC).

In the course of the first all-sky survey (eRASS1), the eROSITA instrument on board the Russian/German Spektrum-Roentgen-Gamma (SRG) mission discovered a strong outburst from RX J0529.8-6556 in the Large Magellanic Cloud (LMC).

We investigate the spin-orbit torque exerted on the magnetic moments of the transition-metal impurities Cr, Mn, Fe, and Co, embedded in the surface of the topological insulator Bi2Te3, in response to an electric field and a consequent electrical current flow in the surface. The multiple scattering problem of electrons off impurity atoms is solved by first-principles calculations within the full-potential relativistic Korringa-Kohn-Rostoker (KKR) Green function method, while the spin-orbit torque calculations are carried out by combining the KKR method with the semiclassical Boltzmann transport equation. We analyze the correlation of the spin-orbit torque to the spin accumulation and spin flux in the impurities and unveil the effect of resonant scattering. In addition, we relate the torque to the resistivity and Joule heat production. We predict that the Mn/Bi2Te3 is optimal among the studied systems.

Παρουσίαση της Ημερίδας «Νέες Τεχνολογίες τροποποίησης του γονιδιώματος: Βιοηθικά Ζητήματα», Σπίτι της Κύπρου, Πρεσβεία της Κυπριακής Δημοκρατίας στην Αθήνα, 21.2.2020.https://spititiskyprou.gr/wp-content/uploads/2020/02/prosklisi-21-feb-2020-esperida-nees-technologies.pdf

Insulin-regulated aminopeptidase (IRAP) is a transmembrane zinc metallopeptidase with many important biological functions and an emerging pharmacological target. Although previous structural studies have given insight on how IRAP recognizes linear peptides, how it recognizes its physiological cyclic ligands remains elusive. Here, we report the first crystal structure of IRAP with the macrocyclic peptide inhibitor HA08 that combines structural elements from angiotensin IV and the physiological substrates oxytocin and vasopressin. The compound is found in the catalytic site in a near canonical substrate-like configuration and inhibits by a competitive mechanism. Comparison with previously solved structures of IRAP along with small-angle X-ray scattering experiments suggests that IRAP is in an open conformation in solution but undergoes a closing conformational change upon inhibitor binding. Stabilization of the closed conformation in combination with catalytic water exclusion by the tightly juxtaposed GAMEN loop is proposed as a mechanism of inhibition.

Previous research has shown that utility value and expectancy forsuccess, as well as the reasons for academic striving, could partlyexplain academic engagement. Yet, their joint role in predictinglearning strategies and test anxiety has not been thoroughlyunderstood, especially in contexts where pressure for success ishigh. We examined this issue in a sample of Turkish universitystudents who were attending a language preparatory school(N¼1009; 53% males,Mage¼19.14years;SD¼1.08) and wereunder the psychological pressure to pass their qualifying exams.Regression analyses showed that next to self-efficacy beliefs, itwas intrinsic reasons which positively and consistently predictedlearning strategies; in contrast, self-worth concerns positively pre-dicted test anxiety. These relations emerged even among stu-dents who experienced failure and were thus psychologicallypressed to succeed. Our findings suggest that intrinsic reasons foracademic striving might play a decisive role even in psychologic-ally pressuring contexts

The Be X-ray binary pulsar 1A 0535+262 has recently been observed in outburst with Swift/BAT and MAXI (ATel #14157, #14173). Since then the pulsar has been rapidly evolving in X-rays.

Dysregulation of glycogen phosphorylase, an enzyme involved in glucose homeostasis, may lead to a number of pathological states such as type 2 diabetes and cancer, making it an important molecular target for the development of new forms of pharmaceutical intervention. Based on our previous work on the design and synthesis of 4-arylamino-1-(β-d-glucopyranosyl)pyrimidin-2-ones, which inhibit the activity of glycogen phosphorylase by binding at its catalytic site, we report herein a general synthesis of 2-substituted-5-(β-d-glucopyranosyl)pyrimidin-4-ones, a related class of metabolically stable, C-glucosyl-based, analogues. The synthetic development consists of a metallated heterocycle, produced from 5-bromo-2-methylthiouracil, in addition to protected d-gluconolactone, followed by organosilane reduction. The methylthio handle allowed derivatization through hydrolysis, ammonolysis and arylamine substitution, and the new compounds were found to be potent (μM) inhibitors of rabbit muscle glycogen phosphorylase. The results were interpreted with the help of density functional theory calculations and conformational analysis and were compared with previous findings.

The core aim of the current paper is to summarize the basic argumentation of the Waltzian program and re-examine it in comparison with the legacy of systemic geopolitics. Which is Waltz’s contribution, what is added by Mearsheimer and what does systemic geopolitical analysis offer in the margins of the relevant debate? Both of them focus on Great Powers, since these are considered without any doubt rational actors shaping international system. On this line of thought, their specific legacy is comparatively analyzed with systemic geopolitics and it is developed on the common basis of “system”. Systemic analysis is their common starting point towards analysis of international affairs and interstate distribution of power. Beyond their contradiction with reference to conclusions and epistemological issues, systemic analysis offers a common framework of understanding and conceptualizing systemic geopolitical analysis and structural realism. For this reason, system-level parameters are considered critical representing an epistemological and methodological prioritization far from blinkered analyses cited by other theoretical and philosophical traditions.

The existence of magnetic activity on the eclipsing binary DV Psc has been known for almost two decades. However, until recently, no evidence of periodic behaviour relevant to this activity had been found. In this study, long-term photometric observations of DV Psc are used to analyze the system's magnetic activity, seek a possible magnetic cycle and determine orbital and physical parameters. The combination of photometric and spectroscopic observations results in a unified model that describes the system over time in terms of variable spot activity. New times of minimum light are determined and an accurate astronomical ephemeris and updated O-C diagram are constructed for a total span of 19 years (1997-2017). The intense magnetic activity, as indicated by strong asymmetries in the light curves (O' Connell effect), and the periodic variation of the O-C diagram are combined to explain the system's behaviour. The existence of a third body, orbiting the eclipsing binary in an eccentric orbit, as well as a magnetic cycle are the most likely scenario.

{The purpose of this study was to investigate the areas from which the serves performed by elite volleyball players were carried out, the zones into where they were directed and their performance in respect to the serve type used per gender. A three-member group of coaches assessed the serve actions of male (M) and female (F) elite players from 20 volleyball games (M=10

Human brain possesses a unique anatomy and physiology. For centuries, methodological barriers and ethical challenges in accessing human brain tissues have restricted researchers into using 2-D cell culture systems and model organisms as a tool for investigating the mechanisms underlying neurological disorders in humans. However, our understanding regarding the human brain development and diseases has been recently extended due to the generation of 3D brain organoids, grown from human stem cells or induced pluripotent stem cells (iPSCs). This system evolved into an attractive model of brain diseases as it recapitulates to a great extend the cellular organization and the microenvironment of a human brain. This chapter focuses on the application of brain organoids in modelling several neurodevelopmental and neurodegenerative diseases.

This study examined the role of parents’ reminiscing style in preschoolers’ memory-related functioning and general emotion regulation. In 87 families, each parent rated their child’s (Mage = 4.07 years, SD = 0.80) emotion regulation and discussed a positive and a negative memory with their child (resulting in 275 conversations). Multilevel analyses showed that children’s rated engagement during the conversation was higher when parents were observed to use autonomy-supportive, elaborative, and positive evaluative reminiscing, while children’s rated disaffection was predicted by low autonomy support, low elaboration, and negative evaluation. Parental positive evaluation also related positively to children’s memory performance. With respect to emotion regulation, only parents’ negative evaluation when talking about negative memories related to higher emotional lability. (PsycInfo Database Record (c) 2020 APA, all rights reserved)

Mediterranean mountain ecosystems have been attractive to human societies due to their valuable resources, but are also susceptible to environmental and climate changes. The Rhodope Mountain Range hosts one of the least disturbed natural forests of Europe and is a conservation priority area in the Southern Balkans. Located in the borderlands of the plain of Macedonia, the forest ecosystem development of Rhodope Mountains was shaped not only by Late Holocene climatic variability, but also by changes in human activities since Byzantine times. Palynological and microscopic charcoal analysis of the Livaditis ombrotrophic bog record offers unique insights into vegetation and landscape evolution under the influence of human land-use practices in the south Rhodope area during the last c.a. 1100 years. The findings show a forested landscape, with well-developed Pinus and Abies forests of in the montane zone and mixed deciduous oak forests below that flourished in the area until 900 AD. The expansion of human activity in mountainous areas during the period of Byzantine economic growth (ca. 1000 AD) is evidenced by forest clearance through fire, affecting mainly the Abies populations. The Livaditis record bears evidence about both, arboriculture and cereal cultivation as well as animal husbandry during the first period of human activities in the uplands, while a shift towards pastoralism is most likely associated with the establishment of the Vlach population in the region (ca. 1200 AD). Subsequently, a short-lived expansion of the Pinus percentages could be attributed to the afforestation of abandoned pasture land during the Little Ice Age. Finally, a further intensification of pastoralism is most likely concurrent with the population expansion documented during the Ottoman period (after 1500 AD). The Livaditis pollen record shows significant vegetation shifts in the upland area of southern Rhodope Mountains that could be associated with changes in climate, population mobility and density, as well as evolving land-use practices.

Background: Thyroid follicular cells have physiologically high levels of reactive oxygen species because oxidation of iodide is essential for the iodination of thyroglobulin (Tg) during thyroid hormone synthesis. Thyroid follicles (the functional units of the thyroid) also utilize incompletely understood autoregulatory mechanisms to defend against exposure to excess iodide. To date, no transcriptomic studies have investigated these phenomena in vivo. Nuclear erythroid factor 2 like 2 (Nrf2 or Nfe2l2) is a transcription factor that regulates the expression of numerous antioxidant and other cytoprotective genes. We showed previously that the Nrf2 pathway regulates the antioxidant defense of follicular cells, as well as Tg transcription and Tg iodination. We, thus, hypothesized that Nrf2 might be involved in the transcriptional response to iodide overload. Methods: C57BL6/J wild-type (WT) or Nrf2 knockout (KO) male mice were administered regular water or water supplemented with 0.05{%} sodium iodide for seven days. RNA from their thyroids was prepared for next-generation RNA sequencing (RNA-Seq). Gene expression changes were assessed and pathway analyses were performed on the sets of differentially expressed genes. Results: Analysis of differentially expressed messenger RNAs (mRNAs) indicated that iodide overload upregulates inflammatory-, immune-, fibrosis- and oxidative stress-related pathways, including the Nrf2 pathway. Nrf2 KO mice showed a more pronounced inflammatory–autoimmune transcriptional response to iodide than WT mice. Compared to previously published datasets, the response patterns observed in WT mice had strong similarities with the patterns typical of Graves' disease and papillary thyroid carcinoma (PTC). Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) also responded to iodide overload, with the latter targeting mRNAs that participate mainly in inflammation pathways. Conclusions: Iodide overload induces the Nrf2 cytoprotective response and upregulates inflammatory, immune, and fibrosis pathways similar to autoimmune hyperthyroidism (Graves' disease) and PTC.

Nutrient transporters, being polytopic membrane proteins, are believed, but not formally shown, to traffic from their site of synthesis, the ER, to the plasma membrane through Golgi-dependent vesicular trafficking. Here, we develop a novel genetic system to investigate the trafficking of a neosynthesized model transporter, the well-studied UapA purine transporter of Aspergillus nidulans. We show that sorting of neosynthesized UapA to the plasma membrane (PM) bypasses the Golgi and does not necessitate key Rab GTPases, AP adaptors, microtubules or endosomes. UapA PM localization is found to be dependent on functional COPII vesicles, actin polymerization, clathrin heavy chain and the PM t-SNARE SsoA. Actin polymerization proved to primarily affect COPII vesicle formation, whereas the essential role of ClaH seems indirect and less clear. We provide evidence that other evolutionary and functionally distinct transporters of A. nidulans also follow the herein identified Golgi-independent trafficking route of UapA. Importantly, our findings suggest that specific membrane cargoes drive the formation of distinct COPII subpopulations that bypass the Golgi to be sorted non-polarly to the PM, and thus serving house-keeping cell functions.

Monoamine oxidases MAOA and MAOB catalyze important cellular functions such as the deamination of neurotransmitters. Correspondingly, MAO inhibitors are used for the treatment of severe neuropsychiatric disorders such as depression. A commonly prescribed drug against refractory depression is tranylcypromine, however, the side effects are poorly understood. In order to decipher putative off-targets, we synthesized two tranylcypromine probes equipped with either an alkyne moiety or an alkyne-diazirine minimal photocrosslinker for in situ proteome profiling. Surprisingly, LC-MS/MS analysis revealed low enrichment of MAOA and relatively promiscuous labeling of proteins. Photoprobe labeling paired with fluorescent imaging studies revealed lysosomal trapping which could be largely reverted by the addition of lysosomotropic drugs.

The heterogeneity of bladder cancer (BlCa) prognosis and treatment outcome requires the elucidation of tumors' molecular background towards personalized patients' management. tRNA-derived fragments (tRFs), although originally considered as degradation debris, represent a novel class of powerful regulatory non-coding RNAs. In silico analysis of the TCGA-BLCA project highlighted 5'-tRF-LysCTT to be significantly deregulated in bladder tumors, and 5'-tRF-LysCTT levels were further quantified in our screening cohort of 230 BlCa patients. Recurrence and progression for non-muscle invasive (NMIBC) patients, as well as progression and patient's death for muscle-invasive (MIBC) patients, were used as clinical endpoint events. TCGA-BLCA were used as validation cohort. Bootstrap analysis was performed for internal validation and the clinical net benefit of 5'-tRF-LysCTT on disease prognosis was assessed by decision curve analysis. Elevated 5'-tRF-LysCTT was associated with unfavorable disease features, and significant higher risk for early progression (multivariate Cox: HR = 2.368; p = 0.033) and poor survival (multivariate Cox: HR = 2.151; p = 0.032) of NMIBC and MIBC patients, respectively. Multivariate models integrating 5'-tRF-LysCTT with disease established markers resulted in superior risk-stratification specificity and positive prediction of patients' progression. In conclusion, increased 5'-tRF-LysCTT levels were strongly associated with adverse disease outcome and improved BlCa patients' prognostication.

In this paper I discuss the possibilities, opportunities, challenges and (even) perils in applying the ELF-aware perspective in teacher education. I focus on presenting two obstacles in enabling this application, the first related to teachers’ attitudes, which tend to be fundamentally negative, and the second referring to an uncertainty about establishing, applying and evaluating appropriate ELF pedagogy. The obstacles are discussed with reference to examples from my personal experience as teacher educator, and argue (a) that these obstacles are also present in more “traditional” teaching and teacher education practices and (b) that they can be overcome if they are perceived as opportunities for integrating real-life interactions involving non-native English language users in the EFL classroom and prompting EFL teacher reflection and growth.

The purpose of this systematic review was to identify adolescents' awareness on the human papillomavirus (HPV), the HPV vaccine, and the willingness to undergo the vaccination. A systematic review of studies concerning the adolescent's knowledge and education on the admission of the HPV vaccine was carried out, through the Medline/PubMed and the Google Scholar databases, covering information on adolescent attitudes towards HPV vaccination, as well as their perceptions regarding the vaccination and the need for more training, towards the public information about the HPV and the HPV vaccine. This study concludes that adolescents are poorly informed about the HPV and the preventive vaccination issues, underestimating the likelihood of the infection by the virus. The way to improve their knowledge about the HPV and the implications of the HPV infection is to provide information through the framework of compulsory schooling, primary health care, and the development of informative interactive interventions. The awareness for the need of training about the HPV and its implications should be broadened to address the major barrier to vaccination, which is regarded to be the lack of adequate information. The knowledge and the perceptible susceptibility to the HPV infection and HPV-related diseases among adolescents demonstrate the need for a well-designed training program to bridge the gap of information about the HPV virus and to accept the HPV vaccine.

Using self-determination theory as a framework, we aimed to study the relationships between perceived need support and need satisfaction with self-determined motivation and extracurricular physical activity intentions in the physical education (PE) classroom, including sex and out-of-school sport participation as moderators. Additionally, we aimed to test whether a need-supportive classroom environment in PE moderates these associations. Participants were 1259 students (556 males) aged between 12 to 16 years (Mage = 13.46 years; SD = 0.74) from 77 PE classes. At the student level we found (a) need satisfaction to predict positively autonomous motivation and negatively amotivation, and (b) autonomous motivation to predict positively and amotivation to predict negatively intentions to undertake extracurricular physical activities. At the classroom level, in need-supportive classes males benefit more than females in terms of increased autonomous motivation while females benefit more than males in terms of decreased amotivation. Finally, class-level perceived need support moderated (i.e., attenuated) the negative association between need satisfaction and amotivation and between amotivation and intentions. These results suggest a buffering role that a need-supportive classroom environment may have on students’ motivation and behavior.

We present the results of the first dedicated observation of the young X-ray pulsar SXP 1062 in the broad X-ray energy band obtained during its 2019 outburst with the NuSTAR and XMM-Newton observatories. The analysis of the pulse-phase averaged and phase-resolved spectra in the energy band from 0.5 to 70 keV did not reveal any evidence for the presence of a cyclotron line. The spin period of the pulsar was found to have decreased to 979.48 ± 0.06 s implying a ∼10% reduction compared to the last measured period during the monitoring campaign conducted about five years ago, and is puzzling considering that the system apparently has not shown major outbursts ever since. The switch of the pulsar to the spin-up regime supports the common assumption that torques acting on the accreting neutron star are nearly balanced and thus SXP 1062 likely also spins with a period close to the equilibrium value for this system. The current monitoring of the source also revealed a sharp drop in its soft X-ray flux right after the outburst, which is in drastic contrast to the behavior during the previous outburst when the pulsar remained observable for years with only a minor flux decrease after the end of the outburst. This unexpected off state of the source lasted for at most 20 days after which SXP 1062 returned to the level observed during previous campaigns. We discuss this and other findings in context of the modern models of accretion onto strongly magnetized neutron stars.

The 1:1 reactions of uranium(iv) tetrakis(borohydride) with the sodium and potassium salts of the cyclobutadienyl anion [C4(SiMe3)4]2- (Cb′′′′) produce the half-sandwich complexes [Na(12-crown-4)2][U(η4-Cb′′′′)(BH4)3] and [U(η4-Cb′′′′)(μ-BH4)3{K(THF)2}]2. In the 1:2 reaction of U(BH4)4 with Na2Cb′′′′, formation of [U(η4-Cb′′′′)(η3-C4H(SiMe3)3-κ-(CH2SiMe2)(BH4))]- reveals that a Cb′′′′ ligand undergoes an intramolecular deprotonation, resulting in an allyl/tuck-in bonding mode. A computational study reveals that the uranium-Cb′′′′ bonding has an appreciable covalent component with contributions from the uranium 5f and 6d orbitals.

The paper presents the design, implementation and evaluation of a teaching intervention for the teaching of Evolution. This is carried out through an evolution-based investigation activity of the nervous system from Protozoan to Humans. Specifically, students were able to follow two main evolutionary pathways related to the Nervous system. In the first place, they were familiarized with a march of the Nervous System (NS) from Protozoans to Vertebrates and from Fishes to Humans. In a second stage they studied and compared the difference between the development of Spatial Memory and Hippocampus between polygamous mice and taxi drivers of NY city. I.e. they were faced with a case of adaptation in a Darwinian evolution way in contrast to a Lamarckian case of an acquired trait. The results of two studies concerning the increased size of the Hippocampus as a result of the impact of the environment and as an adaptive characteristic of reproductive and survival strategies are given to students who are invited to investigate whether this characteristic is inherited or not in the two cases. In addition to the main question, individual concepts of Evolution through Natural Selection and Neurobiology are explored. Teaching intervention is a proposal for the teaching of basic concepts of Evolution through the promotion of the idea of using the Evolution by Natural Selection as the Unifying Theory of Biology. The results show a statistically significant

The brain is one of the most complex organs, responsible for the advanced intellectual and cognitive ability of humans. Although primates are to some extent capable of performing cognitive tasks, their abilities are less evolved. One of the reasons for this is the vast differences in the brain of humans compared to other mammals, in terms of shape, size and complexity. Such differences make the study of human brain development fascinating. Interestingly, the cerebral cortex is by far the most complex brain region resulting from its selective evolution within mammals over millions of years. Unraveling the molecular and cellular mechanisms regulating brain development, as well as the evolutionary differences seen across species and the need to understand human brain disorders, are some of the reasons why scientists are interested in improving their current knowledge on human corticogenesis. Toward this end, several animal models including primates have been used, however, these models are limited in their extent to recapitulate human-specific features. Recent technological achievements in the field of stem cell research, which have enabled the generation of human models of corticogenesis, called brain or cerebral organoids, are of great importance. This review focuses on the main cellular and molecular features of human corticogenesis and the use of brain organoids to study it. We will discuss the key differences between cortical development in human and nonhuman mammals, the technological applications of brain organoids and the different aspects of cortical development in normal and pathological conditions, which can be modeled using brain organoids. This article is categorized under: Comparative Development and Evolution > Regulation of Organ Diversity Nervous System Development > Vertebrates: General Principles.

This paper reflects the opinion of the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) Working Group Accreditation and ISO/CEN standards (WG-A/ISO). It aims to provide guidance for drawing up local/national documents about validation and verification of laboratory methods. We demonstrate how risk evaluation can be used to optimize laboratory policies to meet intended use requirements as well as requirements of standards. This is translated in a number of recommendations on how to introduce risk evaluation in various stages of the implementation of new methods ultimately covering the whole process cycle

The variability of the water mass exchange between the Arabian Gulf and the Indian Ocean is investigated using a high-resolution (1/36°) ocean model. We focus on the period from December 1996 to March 1998, having as reference in situ measurements at the Strait of Hormuz. Previous studies, based on models and observations, suggested a perpetual deep outflow, mainly in the southern part of the Strait, and a variable flow in the upper layers. In the present study, we confirm that there is a permanent core of a deep outflow in the Strait at depths greater than 40 m, characterised by high-salinity waters. In addition, we show that there is a seasonal signal in the upper layers net flow in the southern part of the Strait, altering from net inflow during winter/spring to net outflow during summer/fall. The mean annual inflow through the Strait is estimated at 0.22 ± 0.01 Sv and the deep outflow at 0.147 ± 0.01 Sv. The water mass exchange through the Strait is controlled by synoptic processes with high variability net transport fields. These processes characterise the structure and the intensity of the transport patterns, exhibiting 2- to 5-day period. On synoptic time scales, winds drive an immediate baroclinic flow at the Strait of Hormuz, affecting mostly the upper layers, and a quasi-barotropic flow that peaks approximately 2 days later.

Package recommendation systems have gained in popularity especially in the tourism domain, where they propose combinations of different types of attractions that can be visited by someone during a city tour. These systems can also be applied in suggesting home entertainment, proper nutrition or academic courses. Such systems must optimize multiple user criteria in tandem, such as preference score, package cost or duration. This work proposes a flexible framework for recommending packages that best fit users' preferences while satisfying several constraints on the set of the valid packages. This is achieved by modeling the relation between the items and the categories these items belong to, aiming at recommending to each user the top-k packages that cover their preferred categories and the restriction of a maximum package cost. Our contribution includes an optimal and a greedy algorithm, that both outperform a state-of-the-art system and a popularity-based baseline solution. The novelty of the optimal algorithm is that it combines the collaborative filtering predictions with a graph-based model to produce package recommendations. The problem is expressed through a minimum cost flow network and is solved by integer linear programming. The greedy algorithm has a low computational complexity and provides recommendations which are close to the optimal one. An extensive evaluation of the proposed framework has been carried out on six popular recommendation datasets. The results obtained using a set of widely accepted metrics show promising performance. Finally, the formulation of the problem for specific domains has also been addressed.

Nutritional and lifestyle changes remain at the core of healthy aging and disease prevention. Accumulating evidence underscores the impact of genetic, metabolic, and host gut microbial factors on individual responses to nutrients, paving the way for the stratification of nutritional guidelines. However, technological advances that incorporate biological, nutritional, lifestyle, and health data at an unprecedented scale and depth conceptualize a future where preventative dietary interventions will exceed stratification and will be highly individualized. We herein discuss how genetic information combined with longitudinal metabolomic, immune, behavioral, and gut microbial parameters, and bioclinical variables could define a digital replica of oneself, a "virtual digital twin," which could serve to guide nutrition in a personalized manner. Such a model may revolutionize the management of obesity and its comorbidities, and provide a pillar for healthy aging.

The discovery and analysis of the system CzeV1731 represents a rare configuration of a 2+2 quadruple star system containing two eclipsing binaries, the third system of its kind known to date. The system under investigation in this work is TYC 3929-724-1 (= 2MASS J19245582+5704084 = TIC 284482112), located at RA=19:24:55.82, DE=+57:04:08.39, with Vmax=10.5mag. We present times of eclipses and radial velocities of both pairs. (2 data files).

Figure10.4-0.7keV.fits and Figure10.7-1.25keV XMM-Newton mosaic images of M 31 in the 0.4-0.7keV and 0.7-1.25keV range. We used all XMM-Newton data up to and including our new observations (early 2016). To produce these mosaics we used the the XMM-Newton Extended Source Analysis Software (XMM-ESAS), packaged in SAS1 15.0.0. XMM-ESAS is based on the software used for the background modelling described by Snowden et al. (2004ApJ...610.1182S). The units of the images are cts/s/deg2. See Section 2.1.1 for more details. Figure2_0.4-1.25keV.fits. XMM-Newton image of the northern disk of M 31 in the 0.4-1.25keV range produced as in Figure 1. See Sections 2.1.1 and 2.2 for more details. (2 data files).

Table 1 includes the data from the astrometric monitoring runs for 2002 TC302 carried out to narrow down the shadow path uncertainty, in October, November, December 2017 and January 2018 with the Sierra Nevada 1.5m telescope (Granada, Spain) and the Calar Alto 1.2m telescope (Almeria, Spain). The astrometric catalog used for the occultation prediction was Gaia DR1. Tables 2 and 3 include, respectively, all the photometry and astrometry of 2002 TC302 analyzed, from 2014 to 2019. The astrometry was derived with respect to the Gaia DR2 catalog (Cat. I/345). (3 data files).

Based on observations made with the NASA/ESA Hubble Space Telescope, and obtained from the Hubble Legacy Archive, which is a collaboration between the Space Telescope Science Institute (STScI/NASA), the Space Telescope European Coordinating Facility (ST-ECF/ESA) and the Canadian Astronomy Data Centre (CADC/NRC/CSA). (1 data file).

The COVID-19 pandemic has unhinged the lives of employees across the globe, yet there is little understanding of how COVID-19 health anxiety (CovH anxiety)-that is, feelings of fear and apprehension about having or contracting COVID-19-impacts critical work, home, and health outcomes. In the current study, we integrate transactional stress theory (Lazarus {&} Folkman, 1984) with selfdetermination theory (Deci {&} Ryan, 2000) to advance and test a model predicting that CovH anxiety prompts individuals to suppress emotions, which has detrimental implications for their psychological need fulfillment. In turn, lack of psychological need fulfillment hinders employees' abilities to work effectively, engage with their family, and experience heightened well-being. Our model further predicts that handwashing frequency-a form of problem-focused coping-will mitigate the effects of CovH anxiety. We test our propositions using a longitudinal design that followed 503 employees across the first four weeks that stay-at-home and social distancing orders were enacted. Consistent with predictions, CovH anxiety was found to impair critical work (goal progress), home (family engagement) and health (somatic complaints) outcomes due to increased emotion suppression and lack of psychological need fulfillment. Further, individuals who frequently engage in handwashing behavior were buffered from the negative impact of CovH anxiety. Combined, our work integrates and extends existing theory and has a number of important practical implications. Our research represents a first step to understanding the work-, home-, and health-related implications of this unprecedented situation, highlighting the detrimental impact of the anxiety stemming from the COVID-19 pandemic.

Το κείμενο αντλεί από την αναπλαισιωτική (reconceptual) παράδοση των αναλυτικών προγραμμάτων, η οποία το θεωρεί (μεταξύ άλλων και) ως πολιτικό κείμενο. Εξετάζεται ιστορικά ο τρόπος μετασχηματισμού/μεταρρύθμισης του αναλυτικού προγράμματος στην Ελλάδα, από τη δεκαετία του 1950 και μετά. Αξιοποιώντας ως θεωρητικό-ερμηνευτικό μοντέλο την μη-αναγωγιστική και μη-στρουκτουραλιστική προσέγγιση των φορέων δράσης (agency) καταλήγει στο συμπέρασμα ότι τα) καταλήγει στο συμπέρασμα ότι τα αναλυτικά προγράμματα στην Ελλάδα συγκροτούνται κυρίως από τις επιλογές των πολιτικά κυρίαρχων φορέων δράσης, με αποτέλεσμα να εμπεριέχουν φονταμενταλιστικές στάσεις ως προς τη γνώση και να χαρακτηρίζονται από τη δυσκολία εναρμόνισης με το οικονομικό και κοινωνικό γίγνεσθαι.

Η διασαφήνιση των ορίων ανάμεσα στην εκπαίδευση ενηλίκων και στη συμβουλευτική είναι ένα πεδίο το οποίο συζητάτε χωρίς ωστόσο να έχει διερευνηθεί επαρκώς. Διερευνάται η σχέση ανάμεσα στα δυο πεδίο με βάση τη θεωρία μετασχηματισμών, τον ορισμό της ενηλικιότητας και τη διερεύνηση των δυσλειτουργικών ψυχικών παραδοχών. Δίνεται ο ορισμός της ενηλικιότητας και της ωριμότητας με βάση τη θεωρία μετασχηματισμών και την κατάρρευση των ψευδαισθήσεων της παιδικής ηλικίας. Διερευνώνται τα επτά στάδια προς την ενηλικιότητα καθώς και οι επιπτώσεις των δυσλειτουργικών παραδοχών. Συζητούνται τα όρια ανάμεσα στην συμβουλευτική και στην εκπαίδευση ενηλίκων με προτάσεις για την εκπαίδευση των εκπαιδευτών ενηλίκων.

Funding of research proposals by the European Commission (EC) requires notonly scientific excellence and innovation, but also ethical conduct of research. For thisreason, the EC performs ethics review for all the research proposals that are going to befunded, in order to check compliance with the ethics principles of research, as well asthe European and National laws, in the countries where research is conducted. The aimof the present manuscript is to raise awareness and familiarize researchers with theethics review of research proposals, as conducted in the EC, through the eyes of twoethics experts.Firstly, the stages of the ethics review process are described, which is performedwith the assistance of independent ethics experts. The criteria which are provided andmonitored by the Ethics and Research Integrity Sector in the EC are then presented indetail. Based on these criteria, the possible outcomes of an ethics review are analyzed,which may include the formation of specific requirements that need to be fulfilled by theresearchers. Specific reference is made to the requirements that may result when aresearch proposal involves collection, processing and storage of personal data accordingto the General Data Protection Regulation 2016/679, because this Regulation enteredinto force recently in the ethics review.Finally, reference is made to the importance of ensuring integrity in researchthought the ethics review process, and the necessary compliance with the ethicsstandards of EC-funded research.

Η παρούσα μελέτη συμβάλει στην ανάπτυξη νέων επιστημονικών αντικειμένων που προκύπτουν από τη συνέργεια επιστημών. Αφορά δυνατότητες συνέργειας της Κοινωνικής Παιδαγωγικής και της Θρησκευτικής Εκπαίδευσης (Μυλωνάκου-Κεκέ, 2013∙ Κουκουνάρας Λιάγκης, 2019), που έχουν εμφανιστεί, στο πλαίσιο της τυπικής εκπαίδευσης με βάση τις Ευρωπαϊκές Συστάσεις και Συμβάσεις, τα Ανθρώπινα Δικαιώματα και τα Δικαιώματα του Παιδιού, αλλά και τις σύγχρονες θεωρίες στη θρησκειοπαιδαγωγική και θεολογία. Παρουσιάζονται τα αποτελέσματα της μελέτης της Θρησκευτικής Εκπαίδευσης (μάθημα και έρευνα) και του πλαισίου της, με όρους κοινωνικών συστημάτων (Engeström, 1999; 2005), αλλά και του Υπερ(συν)επιστημονικού Κοινωνικοπαιδαγωγικού Μοντέλου, που έχει σχεδιαστεί με βάση τη διαλεκτική σχέση των θεωριών της Μεθοδολογίας των Ανθρώπινων Συστημάτων, της Συστημικής Επιστήμης (Senge, 2006) και του Μοντέλου της Συνεκπαίδευσης/Syneducation και της Διαχείρισης της Γνώσης (Κεκές, 2007, 2008∙ Mylonakou-Keke, 2015∙  Μυλωνάκου-Κεκέ, 2016). Φαίνεται ότι δημιουργείται ένα διακριτό επιστημονικό πεδίο δράσης κοινού ενδιαφέροντος των δύο επιστημονικών πεδίων, που βασίζεται σε κοινές προϋποθέσεις και επιδιώξεις. Μπορεί, μάλιστα να έχει εφαρμογές στην ολόπλευρη ανάπτυξη του ανθρώπου, στην προσωπική και συλλογική ζωή, και επιπλέον να προκαλεί βελτιωτικές αλλαγές, που είναι ένας από τους βασικούς ρόλους της εκπαίδευσης.

Για έναν περίπου αιώνα (1837-1930), η ελληνική Πολιτεία δεν μερίμνησε για την οργάνωση μιας επίσημης δομής αρχικής κατάρτισης επιφορτισμένης με τη μόρφωση των καθηγητών γαλλικής. Στα τέλη του 19ου αιώνα, το ζήτημα αρχίζει να απασχολεί και τη γαλλική πολιτιστική διπλωματία, η οποία το συνδέει άμεσα με τη διάδοση/διάχυση της γαλλικής γλώσσας και κατ’ επέκταση με την ισχυροποίηση της γαλλικής παρουσίας στο γεωπολιτικό γίγνεσθαι της περιοχής. Η μελέτη αυτή επιχειρεί να αποτυπώσει τους βασικότερους σταθμούς της ιστορίας της εκπαίδευσης των καθηγητών γαλλικής στην Ελλάδα από τη θεσμική ανυπαρξία έως τη συγκρότηση της γαλλικής γραμματείας σε γνωστικό αντικείμενο ακαδημαϊκών σπουδών με την ίδρυση τμημάτων στα πανεπιστήμια Αθηνών και Θεσσαλονίκης (1954). Να αναδείξει επίσης ότι, πέρα από την ελληνική κοινωνικοοικονομική και πολιτική συγκυρία που τη χάραξε, η πορεία του ζητήματος αυτού έχει και διπλωματικές/διεθνικές προεκτάσεις, καθώς συνδέεται άμεσα και με πολιτικές που αναπτύχθηκαν στο πλαίσιο μιας ελληνογαλλικής μορφωτικής συνεργασίας. Η εκπαιδευτική αυτή σύμπραξη Ελλάδας-Γαλλίας αποδεικνύεται ωστόσο αμφίσημη, καθώς εξυπηρετεί διαφορετικούς πολιτιστικούς στόχους, διαφορετικά πολιτικά και διπλωματικά συμφέροντα και διακυβεύματα.  "The French teacher education in Greece in the 19th and 20th centuries: aspects of an ambiguous Greek-French cultural collaboration" For about a century (1837-1930), the Greek State did not accommodate the organization of a formal educational structure of initial training for French teachers. At the end of the 19th century this became an issue for the French cultural diplomacy who directly linked this to the spreading of the French language and by extension to the strengthening of the French presence in the Balkan geopolitical scene. In the following study, it is attempted to map the main landmarks of the history of French teachers’ education in Greece, from institutional non-existence until the establishment of the French Language and Literature as an academic discipline with the founding of departments at the Universities of Athens and Thessaloniki (1954). Another aim of the current study is to highlight that, in addition to the Greek socio-economic and political context that has shaped it, this issue also has diplomatic / international implications, as it is directly linked to policies developed in the context of Greek-French cooperation. This educational partnership between Greece and France, however, proves to be rather ambiguous, erratic, often confrontational, since it serves different cultural goals, different political and diplomatic interests and stakes.

©       Καμπερίδου, Ειρ. (2020). Η ΣΥΛΛΕΚΤΙΚΗ ΜΑΝΙΑ ΤΩΝ ΕΥΡΩΠΑΙΩΝ: Η ΑΡΠΑΓΗ ΚΑΙ Η ΣΥΛΗΣΗ ΑΡΧΑΙΟΤΗΤΩΝ. Φιλοσοφία και Παιδεία. Τεύχος 81-82, Μάρτιος-Σεπτέμβριος 2020., σελ. 32-37. Έκδοση της Ένωσης Καθηγητών για την Προαγωγή της Φιλοσοφίας στην Εκπαίδευση (Ε.Κ.Δ.Ε.Φ.).

«Εσείς οι Άγγλοι μας παίρνετε τα έργα των προγόνων μας. Φυλάξτε τα καλά. Εμείς οι Έλληνες στο μέλλον θα τα ζητήσουμε πίσω» (Αθανάσιος Ψαλίδας 1809).    Μια νέα εξέλιξη προέκυψε αναφορικά με το θέμα των γλυπτών του Παρθενώνα που απέσπασε ο Lord Elgin στις αρχές του 19ου αιώνα και εκτίθενται στο Βρετανικό Μουσείο σήμερα. Δυο Τούρκοι επιστήμονες (Ζεϊνέπ Αϊγκέν και  Ορχάν Σακίν) εξετάζοντας τα οθωμανικά αρχεία, καταρρίπτουν τους ισχυρισμούς των Βρετανών πως είχαν λάβει άδεια από τον σουλτάνο για την ‘αρπαγή’. Αποδεικνύεται ότι το Βρετανικό Μουσείο βασίζει τους ισχυρισμούς του σε μια ιταλική μετάφραση του φερόμενου ως πρωτότυπου σουλτανικού φιρμανιού (άδειας). Οι δύο Τούρκοι επιστήμονες ήρθαν στην Αθήνα στις 23 Φεβρουαρίου 2019 και σε συνεργασία με Έλληνες ομολόγους τους, αποφάνθηκαν πως δεν υπάρχει σουλτανικό φιρμάνι. Αρχαία ελληνικά ευρήματα και έργα τέχνης υπάρχουν σήμερα σε όλο τον κόσμο. Συλλεκτική μανία είχε καταλάβει τις ευρωπαϊκές αυλές και τους μεγιστάνες του πλούτου ήδη, από την αυγή της Αναγέννησης. «Είναι θλιβερή η διαπίστωση», έγραφε τον 19ο αιώνα, ο François-René de Chateaubriand, «ότι οι πολιτισμένοι ευρωπαϊκοί λαοί προξένησαν στα μνημεία των Αθηνών περισσότερο κακό κατά τη διάρκεια 150 χρόνων από’ όσο όλοι μαζί οι βάρβαροι κατά τη διάρκεια των αιώνων. Είναι σκληρό να σκεφτεί κανείς ότι ο Αλάριχος και ο Μωάμεθ Β’ σεβάστηκαν τον Παρθενώνα, για να τον αφανίσουν ο Μοροζίνι και ο Έλγιν». Είναι βέβαιο ότι η πολιτισμική κληρονομιά ενός τόπου, δεν είναι μόνο οι αρχαιότητες και τα παλαιά έργα τέχνης. Είναι η πνευματική του δημιουργία που σε συνδυασμό με την ιστορική-πολιτισμική μνήμη συγκροτούν καθημερινή βιωματική εμπειρία, η  οποία δεν μπορεί να κλαπεί και να δημοπρατηθεί. Είναι λυπηρό που η διεθνής κοινότητα στέκεται με απάθεια μπροστά στο δράμα της πολιτιστικής κληρονομιάς ενός τόπου, που αποτελεί μέρος της παγκόσμιας πολιτιστικής κληρονομιάς! [στο τυπογραφείο-υπό έκδοση, καθυστέρηση λόγω μέτρων/Covid 19]

Εισήγηση στην ημερίδα με τίτλο: «Τεχνητή Νοημοσύνη στην Ιατρική Απεικόνιση, Εφαρμογές, προοπτική, ηθικά και φιλοσοφικά ζητήματα», 12.10.2019, Αθήνα.

The time of Photios the Great was crucial for the Jewish-Christian relations. The Byzantine Empire exited the iconoclastic controversy in 842 AD, for which the Jews had been partly held responsible. In 861 AD, the Byzantines attempted to approach the Khazars, who had largely embraced Judaism. Furthermore, starting in 872, emperor Basil I made a series of attempts to convert the Byzantine Jews to Christianity.This historical background is reflected by the numerous references to the Jews in Photios’s works. Photios generally utilizes acute anti-Jewish rhetoric, through which he seems to be seeking to construct a unified Christian identity following the iconoclastic divide. It is noteworthy, however, that Photios focuses his anti-Jewish rhetoric on the events of the New Testament, while he avoids referring to the Jews of his time and thereby inciting tension towards them. He also makes positive remarks about Jewish believers and states his faith in the eschatological conversion of all Jews to Christianity. While Photios addresses his sermons and writings to an exclusively Christian audience, the discourse of modern-day Church is de facto addressed to humanity as a whole. Therefore, our Church should rather adopt a rhetoric of reconciliation, promote a sincere theological discourse, and transcend all sorts of stereotypes. The theological dialogue between the Byzantines and the Khazars, inspired by Photios the Great, is a valuable precedent in this endeavor.

International tendencies and the dominant educational policy that is associated with special education is focusing on integration practices and the promotion of inclusive education. The purpose of the given investigation was to imprintthe thoughts of principals of special education school settings, regarding the currently applied educational status of special education inGreece. The researchers, through semi-structured interviews, aimed to designate the factors that contribute to forming the inclusion politics in general education classrooms of students with some form of disability. The content analysis of the data that were collected by the investigators, lead them in the conclusion that it is of high importance to consider the school culture as a significant factor of the degree of which students with disabilities can be included in general education and the quality of the cooperation that will be developed through the principles and the educational stuff.  

Religion is a key theme in the learning process that aims to design, reflect, and transform knowledge in order for students to acquire the ability to: reflect on issues of social, economic, political and cultural pluralism, take reflective action which leads to responsible citizenship, bring about transformation and social change, enable understanding, and manage diversity through synthesis, collaboration, dialogue and creative debate, while cultivating a consciousness that leverages any local and differring elements. The above pedagogical approaches to the curriculum are presented here, focusing on the role of knowledge of religion in preschool and first-school education. The local environment, the family, the person‟s religion, and other persons of religion in the environment at pre-school and of pre-school age, have a role to play in the process of constructing the personal identity that is carried out in school by meaningful personal experiences. This process of giving meaning requires the student to know the language, to be literate and in this case the religious language. Literacy in the early years of school is fundamental to a child's development and maturity. Religious literacy is therefore essential from an early age, since it has a profound effect. Therefore, it is about the zone of proximal development, i.e. the functions that have not yet matured but are in the process of maturing.

From the very beginning of the establishment of the Church, education and peda-gogy had beenat the epicenter of the thought of great theologians and Christian philosophers as anthropomorphic ideals, which civilization offers to societies in order to form complete and integrated personalities capable to understand the truth about life, the world,and their place in it. The Church Father’s knowledge is based on Divine Wisdom which they passed to the community of believers in proclamations, preaching, witnessing and which was also shared at the gathering of worshiping communities.

Late years, innovative close-range remote sensing technology such as Unmanned Aerial Vehicle (UAV) photogrammetry and Terrestrial Laser Scanning (TLS) are widely applied in the field of geoscience due to their efficiency in collecting data about surface morphology. Their main advantage stands on the fact that conventional methods are mainly collecting point measurements such as compass measurements of bedding and fracture orientation solely from accessible areas. The current research aims to demonstrate the applicability of UAVs in managing landslide and rockfall hazard in mountainous environments during emergency situations using object-based approach. Specifically, a detailed UAV survey took place in a test site namely as Proussos, one of the most visited and famous Monasteries in the territory of Evritania prefecture, in central Greece. An unstable steep slope across the sole road network results in continuous failures and road cuts after heavy rainfall events. Structure from Motion (SfM) photogrammetry is used to provide detailed 3D point clouds describing the surface morphology of landslide objects. The latter resulted from an object-based classification approach of the photogrammetric point cloud products into homogeneous and spatially connected elements. In specific, a knowledge-based ruleset has been developed in accordance with the local morphometric parameters. Orthomosaic and DSM were segmented in meaningful objects based on a number of geometrical and contextual properties and classified as a landslide object (scarp, depletion zone, accumulation zone). The resulted models were used to detect and characterize 3D landslide features and provide a hazard assessment in respect to the road network. Moreover, a detailed assessment of the identified failure mechanism has been provided. The proposed study presents the effectiveness and efficiency of UAV platforms to acquire accurate photogrammetric datasets from high-mountain environments and complex surface topographies and provide a holistic object-based framework to characterize the failure site based on semantic classification of the landslide objects.

FeGe in the B20 phase is an experimentally well-studied prototypical chiral magnet exhibiting helical spirals, skyrmion lattices, and individual skyrmions with a robust length of 70 nm. While the helical spiral ground state can be verified by first-principles calculations based on density functional theory, this feature size could not be reproduced even approximately. To develop a coherent picture of the discrepancy between experiment and theory, we investigate in this work the magnetic properties of FeGe from first principles using different electronic-structure methods. We study atomistic as well as micromagnetic parameters describing exchange and Dzyaloshinskii-Moriya interactions, and discuss their subtle dependence on computational, structural, and correlation parameters. In particular, we quantify how these magnetic properties are affected by changes of the lattice parameter, different atomic arrangements, exchange and correlation effects, finite Fermi-function broadening, and momentum-space sampling. In addition, we use the obtained atomistic parameters to determine the corresponding Curie temperature, which agrees well with experiments. Our results indicate that the well-known and well-accepted relation between the micromagnetic parameters and the period of the helical structure is not valid for FeGe. This calls for new experiments exploring the relation by measuring independently the spin stiffness, the spiralization, and the period of the helical spin spiral.

Detection and differentiation of enantiomers in small quantities are crucially important in many scientific fields, including biology, chemistry, and pharmacy. Chiral molecules manifest their handedness in their interaction with the chiral state of light (e.g., circularly polarized light), which is commonly leveraged in circular dichroism (CD) spectroscopy. However, compared to the linear refractive index molecular chirality is extremely weak, resulting in low detection efficiencies. Recently, it has been shown that these weak chiroptical signals can be enhanced by increasing the optical chirality of the electromagnetic fields interacting with chiral samples. Here, we show numerically and analytically that dielectric structures can provide an optimum chiral sensing platform by offering uniform superchiral near-fields. To illustrate this, we first study a simple dielectric dimer and show that circularly polarized light can induce parallel and out of phase electric and magnetic fields, which are spectrally and spatially overlapped, and therefore produce superchiral fields at the midpoint of the dimer. This behavior is in contrast to, for example, a plasmonic dimer, where the optical chirality is limited by the electric dipolar field, which is not completely out of phase with the incident magnetic field. With the insights gained from this analysis, next we develop an approach for overlapping electric and magnetic fields in a single particle, based on Kerker effect. In particular, we introduce a Kerker-inspired metasurface consisting of holey dielectric disks, which offers uniform and accessible superchiral near-fields with CD signal enhancements of nearly 24 times. © 2019 American Chemical Society.

The Fermi Gamma-Ray Space Telescope observations of blazars show a strong correlation between the spectral index of their γ-ray spectra and their synchrotron peak frequency ν _{pk}^{syn}; additionally, the rate of Compton dominance of these sources also seems to be a function of ν _{pk}^{syn}. In this work, we adopt the assumption that the non-thermal emission of blazars is primarily due to radiation by a population of Fermi-accelerated electrons in a relativistic outflow (jet) along the symmetry axis of the blazar's accretion disc. Furthermore, we assume that the Compton component is related to an external photon field of photons, which are scattered from particles of the magnetohydrodynamic wind emanating from the accretion disc. Our results reproduce well the aforementioned basic observational trends of blazar classification by varying just one parameter, namely the mass accretion rate on to the central black hole.

The purpose of this study was to illustrate the usefulness of ultrasound in the early diagnosis of occult scaphoid fractures. Forty-eight patients with clinical symptoms of scaphoid fracture and negative initial X-rays were examined. All patients underwent ultrasonography in the emergency room (ER). After 14 days, a computed tomography (CT) scan was performed, which confirmed or not the initial suspicion of fracture. Twenty-two patients were found with subperiosteal hematoma, while six also had cortical discontinuity. The sensitivity of ultrasound in the diagnosis of occult scaphoid fractures was 90% and the specificity was 85.7%. The positive prognostic value was 81.8%. The authors support the use of the scaphoid ultrasound only under strict circumstances. If subperiosteal hematoma or cortical discontinuity is present, there is a high likelihood of scaphoid fracture. On the contrary, if the ultrasound is negative and symptoms persist, the patient will require a CT scan or magnetic resonance imaging for definitive diagnosis. (Journal of Surgical Orthopaedic Advances 28(1):1-9, 2019).

PurposeThe purpose of this paper is to examine the performance of Greek equity mutual funds and the persistence in annual performance for the period 2008-2017 by using a variety of performance models. Design/methodology/approachUsing all the available funds in operation and daily data, the authors apply single-index (Jensen, 1968) and multi-factor models (Fama and French, 1993; Carhart, 1997) to measure risk-adjusted returns. To assess performance persistence, a series of parametric (Bollen and Busse, 2005) and nonparametric tests (Malkiel, 1995; Brown and Goetzmann, 1995; Kahn and Rudd, 1995) is implemented. FindingsResults show that the Greek equity mutual funds perform, on average, worse than the market index, irrespective of the performance measure applied, and the estimations obtained by the models are similar. Few managers that followed large-cap strategies, pursued stocks with high book-to-market value ratio and eliminated their exposure to the momentum effect were able to add value to their portfolios. Furthermore, a winner-picking strategy based on sustained superior performers is questioned. However, assigning fund returns to the corresponding risk factors results in the partial disappearance of persistence in performance. Originality/valueThe sample period includes the turbulent period, following the introduction of capital controls, which affected capital flows significantly. Moreover, the application of multiple performance measures enables us to investigate performance persistence in a wider spectrum.

Surface functionalization of TiO2 inverse opals by graphene oxide nanocolloids (nanoGO) presents a promising modification for the development of advanced photocatalysts that combine slow photon-assisted light harvesting, surface area, and mass transport of macroporous photonic structures with the enhanced adsorption capability, surface reactivity, and charge separation of GO nanosheets. In this work, post-thermal reduction of nanoGO-TiO2 inverse opals was investigated in order to explore the role of interfacial electron transfer vs. pollutant adsorption and improve their photocatalytic activity. Photonic band gap-engineered TiO2 inverse opals were fabricated by the coassembly technique and were functionalized by GO nanosheets and reduced under He at 200 and 500 °C. Comparative performance evaluation of the nanoGO-TiO2 films on methylene blue photodegradation under UV-VIS and visible light showed that thermal reduction at 200 °C, in synergy with slow photon effects, improved the photocatalytic reaction rate despite the loss of nanoGO and oxygen functional groups, pointing to enhanced charge separation. This was further supported by photoluminescence spectroscopy and salicylic acid UV-VIS photodegradation, where, in the absence of photonic effects, the photocatalytic activity increased, confirming that fine-tuning of interfacial coupling between TiO2 and reduced nanoGO is a key factor for the development of highly efficient photocatalytic films. © 2019 by the authors.

Surface functionalization of TiO2 inverse opals by graphene oxide nanocolloids (nanoGO) presents a promising modification for the development of advanced photocatalysts that combine slow photon-assisted light harvesting, surface area, and mass transport of macroporous photonic structures with the enhanced adsorption capability, surface reactivity, and charge separation of GO nanosheets. In this work, post-thermal reduction of nanoGO-TiO2 inverse opals was investigated in order to explore the role of interfacial electron transfer vs. pollutant adsorption and improve their photocatalytic activity. Photonic band gap-engineered TiO2 inverse opals were fabricated by the coassembly technique and were functionalized by GO nanosheets and reduced under He at 200 and 500 °C. Comparative performance evaluation of the nanoGO-TiO2 films on methylene blue photodegradation under UV-VIS and visible light showed that thermal reduction at 200 °C, in synergy with slow photon effects, improved the photocatalytic reaction rate despite the loss of nanoGO and oxygen functional groups, pointing to enhanced charge separation. This was further supported by photoluminescence spectroscopy and salicylic acid UV-VIS photodegradation, where, in the absence of photonic effects, the photocatalytic activity increased, confirming that fine-tuning of interfacial coupling between TiO2 and reduced nanoGO is a key factor for the development of highly efficient photocatalytic films. © 2019 by the authors.

As a rule, exegetes consider John 5:14a merely as the geographical and chronological setting for Jesus' admonition to the previously lame man in 5:14b. However, by combining the methodological approaches of narrative criticism and history of tradition, some implicit narrative and theological motifs are revealed. These relate to the emotional state and way of thinking of the healed man as a narrative character, as well as to the theological meaning of his encounter with Jesus in the Temple-area. Mutatis mutandis, by noticing these implicit motifs, the implied readers can potentially understand this encounter as being in line with the Old Testament Temple-epiphanies.

BACKGROUND: Frontotemporal dementia is a heterogenous neurodegenerative disorder, with about a third of cases being genetic. Most of this genetic component is accounted for by mutations in GRN, MAPT, and C9orf72. In this study, we aimed to complement previous phenotypic studies by doing an international study of age at symptom onset, age at death, and disease duration in individuals with mutations in GRN, MAPT, and C9orf72. METHODS: In this international, retrospective cohort study, we collected data on age at symptom onset, age at death, and disease duration for patients with pathogenic mutations in the GRN and MAPT genes and pathological expansions in the C9orf72 gene through the Frontotemporal Dementia Prevention Initiative and from published papers. We used mixed effects models to explore differences in age at onset, age at death, and disease duration between genetic groups and individual mutations. We also assessed correlations between the age at onset and at death of each individual and the age at onset and at death of their parents and the mean age at onset and at death of their family members. Lastly, we used mixed effects models to investigate the extent to which variability in age at onset and at death could be accounted for by family membership and the specific mutation carried. FINDINGS: Data were available from 3403 individuals from 1492 families: 1433 with C9orf72 expansions (755 families), 1179 with GRN mutations (483 families, 130 different mutations), and 791 with MAPT mutations (254 families, 67 different mutations). Mean age at symptom onset and at death was 49.5 years (SD 10.0; onset) and 58.5 years (11.3; death) in the MAPT group, 58.2 years (9.8; onset) and 65.3 years (10.9; death) in the C9orf72 group, and 61.3 years (8.8; onset) and 68.8 years (9.7; death) in the GRN group. Mean disease duration was 6.4 years (SD 4.9) in the C9orf72 group, 7.1 years (3.9) in the GRN group, and 9.3 years (6.4) in the MAPT group. Individual age at onset and at death was significantly correlated with both parental age at onset and at death and with mean family age at onset and at death in all three groups, with a stronger correlation observed in the MAPT group (r=0.45 between individual and parental age at onset, r=0.63 between individual and mean family age at onset, r=0.58 between individual and parental age at death, and r=0.69 between individual and mean family age at death) than in either the C9orf72 group (r=0.32 individual and parental age at onset, r=0.36 individual and mean family age at onset, r=0.38 individual and parental age at death, and r=0.40 individual and mean family age at death) or the GRN group (r=0.22 individual and parental age at onset, r=0.18 individual and mean family age at onset, r=0.22 individual and parental age at death, and r=0.32 individual and mean family age at death). Modelling showed that the variability in age at onset and at death in the MAPT group was explained partly by the specific mutation (48%, 95% CI 35-62, for age at onset; 61%, 47-73, for age at death), and even more by family membership (66%, 56-75, for age at onset; 74%, 65-82, for age at death). In the GRN group, only 2% (0-10) of the variability of age at onset and 9% (3-21) of that of age of death was explained by the specific mutation, whereas 14% (9-22) of the variability of age at onset and 20% (12-30) of that of age at death was explained by family membership. In the C9orf72 group, family membership explained 17% (11-26) of the variability of age at onset and 19% (12-29) of that of age at death. INTERPRETATION: Our study showed that age at symptom onset and at death of people with genetic frontotemporal dementia is influenced by genetic group and, particularly for MAPT mutations, by the specific mutation carried and by family membership. Although estimation of age at onset will be an important factor in future pre-symptomatic therapeutic trials for all three genetic groups, our study suggests that data from other members of the family will be particularly helpful only for individuals with MAPT mutations. Further work in identifying both genetic and environmental factors that modify phenotype in all groups will be important to improve such estimates. FUNDING: UK Medical Research Council, National Institute for Health Research, and Alzheimer's Society

There are estimated to be 74,000-134,000 patients living with chronic hepatitis C in Greece, but only 20-30% of them are aware of their disease status. In July 2017, the Hellenic National Plan for Hepatitis C was announced in alignment with the World Health Organization goals for the eradication of hepatitis C virus (HCV) by the year 2030. This article discusses the epidemiology and current treatment of chronic hepatitis C in Greece. Additionally the authors propose actions on how to bring back to care diagnosed patients lost to follow up, optimize access to care for HCV-infected people who inject drugs, and increase HCV screening in the general population. The medical community in Greece can play a pivotal role in the implementation of the HCV National Plan and in the efforts to reach the goal of HCV elimination.

The Lavrion district of the Attica Peninsula, Greece, exposes the West Cycladic Detachment System (WCDS), a low-angle crustal-scale extensional fault system separating tectonostratigraphic units of the Cycladic Blueschist Unit. New multiple single-grain fusion and step-heated white mica 40Ar/39Ar ages integrated with existing (U–Th)/He ages and independent paleothermometry resolves a syn- to post-orogenic deformation history. A structurally higher unit records Oligocene greenschist facies deformation that evolved into brittle conditions by the middle Miocene, and shares a similar history to Serifos at the southern end of the detachment system. The structurally lowest unit remained ductile until the late Miocene, preserving pervasive post-orogenic structures, similar to along-strike structures at the centre, deepest part of the fault. The similarities of structural styles and the timing of deformation across > 150 km of strike length of the detachment system indicates tens of kilometers of offset and extraordinary potential for correlating observations along Cycladic-style detachment systems.

© 2019 John Wiley & Sons Ltd The Lavrion district of the Attica Peninsula, Greece, exposes the West Cycladic Detachment System (WCDS), a low-angle crustal-scale extensional fault system separating tectonostratigraphic units of the Cycladic Blueschist Unit. New multiple single-grain fusion and step-heated white mica 40 Ar/ 39 Ar ages integrated with existing (U–Th)/He ages and independent paleothermometry resolves a syn- to post-orogenic deformation history. A structurally higher unit records Oligocene greenschist facies deformation that evolved into brittle conditions by the middle Miocene, and shares a similar history to Serifos at the southern end of the detachment system. The structurally lowest unit remained ductile until the late Miocene, preserving pervasive post-orogenic structures, similar to along-strike structures at the centre, deepest part of the fault. The similarities of structural styles and the timing of deformation across > 150 km of strike length of the detachment system indicates tens of kilometers of offset and extraordinary potential for correlating observations along Cycladic-style detachment systems.

Being an assembly of highly sophisticated protein machines, cells depend heavily on proteostatic modules functionality and on adequate supply of energetic molecules for maintaining proteome stability. Yet, our understanding of the adaptations induced by multigenerational proteotoxic stress is limited. We report here that multigenerational ({\textgreater}80 generations) proteotoxic stress in Oregon R flies induced by constant exposure to developmentally nonlethal doses of the proteasome inhibitor bortezomib (BTZ) ( G80-BTZ flies) increased proteome instability and redox imbalance, reduced fecundity and body size, and caused neuromuscular defects; it also accelerated aging. G80-BTZ flies were mildly resistant to increased doses of BTZ and showed no age-related loss of proteasome activity; these adaptations correlated with sustained upregulation of proteostatic modules, which however occurred at the cost of minimal responses to increased BTZ doses and increased susceptibility to various types of additional proteotoxic stress, namely, autophagy inhibition or thermal stress. Multigenerational proteome instability and redox imbalance also caused metabolic reprogramming being evidenced by altered mitochondrial biogenesis and suppressed insulin/IGF-like signaling (IIS) in G80-BTZ flies. The toxic effects of multigenerational proteome instability could be partially mitigated by a low-protein diet that extended G80-BTZ flies' longevity. Overall, persistent proteotoxic stress triggers a highly conserved adaptive metabolic response mediated by the IIS pathway, which reallocates resources from growth and longevity to somatic preservation and stress tolerance. Yet, these trade-off adaptations occur at the cost of accelerated aging and/or reduced tolerance to additional stress, illustrating the limited buffering capacity of survival pathways.

Malformations of the human cortex represent a major cause of disability1. Mouse models with mutations in known causal genes only partially recapitulate the phenotypes and are therefore not unlimitedly suited for understanding the molecular and cellular mechanisms responsible for these conditions2. Here we study periventricular heterotopia (PH) by analyzing cerebral organoids derived from induced pluripotent stem cells (iPSCs) of patients with mutations in the cadherin receptor-ligand pair DCHS1 and FAT4 or from isogenic knockout (KO) lines1,3. Our results show that human cerebral organoids reproduce the cortical heterotopia associated with PH. Mutations in DCHS1 and FAT4 or knockdown of their expression causes changes in the morphology of neural progenitor cells and result in defective neuronal migration dynamics only in a subset of neurons. Single-cell RNA-sequencing (scRNA-seq) data reveal a subpopulation of mutant neurons with dysregulated genes involved in axon guidance, neuronal migration and patterning. We suggest that defective neural progenitor cell (NPC) morphology and an altered navigation system in a subset of neurons underlie this form of PH.

In the case of type 2 diabetes, inhibitors of glycogen phosphorylase (GP) may prevent unwanted glycogenolysis under high glucose conditions and thus aim at the reduction of excessive glucose production by the liver. Anomeric spironucleosides, such as hydantocidin, present a rich synthetic chemistry and important biological function (e.g., inhibition of GP). For this study, the Suárez radical methodology was successfully applied to synthesize the first example of a 1,6-dioxa-4-azaspiro[4.5]decane system, not previously constructed via a radical pathway, starting from 6-hydroxymethyl-β-d-glucopyranosyluracil. It was shown that, in the rigid pyranosyl conformation, the required [1,5]-radical translocation was a minor process. The stereochemistry of the spirocycles obtained was unequivocally determined based on the chemical shifts of key sugar protons in the 1H-NMR spectra. The two spirocycles were found to be modest inhibitors of RMGPb.

Prothymosin $\alpha$ (proT$\alpha$) and its C-terminal decapeptide proT$\alpha$(100–109) were shown to pleiotropically enhance innate and adaptive immune responses. Their activities have been broadly studied in vitro, focusing primarily on the restoration of the deficient immunoreactivity of cancer patients' leukocytes. Previously, we showed that proT$\alpha$ and proT$\alpha$(100–109) act as danger-associated molecular patterns (DAMPs), ligate Toll-like receptor-4, signal through TRIF- and MyD88-dependent pathways, promote the maturation of dendritic cells and elicit T-helper type 1 (Th1) immune responses in vitro, leading to the optimal priming of tumor antigen-reactive T-cell functions. Herein, we assessed their activity in a preclinical melanoma model. Immunocompetent mice bearing B16.F1 tumors were treated with two cycles of proT$\alpha$ or proT$\alpha$(100–109) together with a B16.F1-derived peptide vaccine. Coadministration of proT$\alpha$ or proT$\alpha$(100–109) and the peptide vaccine suppressed melanoma-cell proliferation, as evidenced by reduced tumor-growth rates. Higher melanoma infiltration by CD3+ T cells was observed, whereas ex vivo analysis of mouse total spleen cells verified the in vivo induction of melanoma-reactive cytotoxic responses. Additionally, increased levels of proinflammatory and Th1-type cytokines were detected in mouse serum. We propose that, in the presence of tumor antigens, DAMPs proT$\alpha$ and proT$\alpha$(100–109) induce Th1-biased immune responses in vivo. Their adjuvant ability to orchestrate antitumor immunoreactivities can eventually be exploited therapeutically in humans.

Due to ice melting, the energy reserves in the Arctic Ocean have become accessible. Therefore, with reference to the climatic changes that have been taking place in recent years, the aim of this paper is to analyze the reallocation of power in the geopolitical complex of the Arctic Ocean, through the context of the distribution, availability and development of the energy reserves in the area . That includes the study of the energy dividends of the Arctic Ocean’s coastal states as well as the strategic and political importance of the geopolitical complex of the research, in terms of energy.

OBJECTIVES: Three-dimensional (3D) bioprinting, a method derived from additive manufacturing technology, is a recent and ongoing trend for the construction of 3D volumetric structures. The purpose of this systematic review is to summarize evidence from existing human and animal studies assessing the application of 3D printing on bone repair and regeneration in the craniofacial region. DATA & SOURCES: A rigorous search of all relevant clinical trials and case series was performed, based on specific inclusion and exclusion criteria. The search was conducted in all available electronic databases and sources, supplemented by a manual search, in December 2017. STUDY SELECTION: 43 articles (6 human and 37 animal studies) fulfilled the criteria. The human studies included totally 81 patients with craniofacial bone defects. Titanium or hydroxylapatite scaffolds were most commonly implanted. The follow-up period ranged between 6 and 24 months. Bone repair was reported successful in nearly every case, with minimal complications. Also, animal intervention studies used biomaterials and cells in various combination, offering insights into the techniques, through histological, biochemical, histomorphometric and microcomputed tomographic findings. The results in both humans and animals, though promising, are yet to be verified for clinical impact. CONCLUSIONS: Future research should be focused on well-designed clinical trials to confirm the short- and long- term efficacy of 3D printing strategies for craniofacial bone repair. CLINICAL SIGNIFICANCE: Emerging 3D printing technology opens a new era for tissue engineering. Humans and animals on application of 3D printing for craniofacial bone repair showed promising results which will lead clinicians to investigate more thoroughly alternative therapeutic methods for craniofacial bone defects.

 

 

  

Fires affecting large areas usually create a mosaic of recovering plant communities reflecting their pre-fire composition and local conditions of burning. However, post-fire recovery patterns may also reveal the effects of landscape heterogeneity on the natural regeneration process of plant communities. This study combines field data and remote sensing image interpretation techniques to assess the role of various landscape characteristics in the post-fire recovery process in a mountainous region of Greece burned by a severe wildfire. Remote sensing techniques were used to accurately map secluded, large burned areas. By introducing a temporal component, we explored the correlation between post-fire regeneration and underlying topography, soils and basement rock. Pre-fire forest cover was reduced by more than half 8 years after fire. Regarding the dominant pre-fire forest trees, Abies cephalonica did not regenerate well after fire and most pre-fire stands were converted to grasslands and shrublands. In contrast, Pinus nigra regenerated sufficiently to return to its pre-fire cover, especially in areas underlain by softer basement rock. The use of different time series of high-resolution images improved the quality of the results obtained, justifying their use despite their high cost.

Mediterranean Temporary Ponds (MTPs) constitute priority habitat under the European Union Habitats’ Directive. They are inhabited by rare species and subjected to unstable environmental conditions. Lakes and ponds act as early indicators of climate change, to which high altitude ecosystems are especially vulnerable. This study presents a full dataset of the geo-environmental parameters of such habitats (MTPs) along with their current ecological status for the first time. Furthermore, this paper aims to address the lack of basic geo-environmental background on the network of MTPs of Mt. Oiti concerning their geological, geomorphological, mineralogical and geochemical characteristics along with the pressures received from various activities. The study area is located in a mountainous Natura 2000 site of Central Greece, which hosts four MTPs. Fieldwork and sampling of water and bottom sediments were carried out during dry and wet periods between 2012 and 2014. Electrical Resistivity Tomography measurements identified synforms shaped under the ponds that topography does not always adopt them, mostly due to erosion procedures. The most significant feature, distinguishing those pond waters from any other province water bodies is the extremely low content of all studied ions (including NO2−, NO3−, NH4+, PO43−, HCO3−, SO42−, Al, As, B, Ba, Ca, Cd, Ce, Cl, Co, Cr, Cs, Cu, Fe, Ga, Gd, Ge, Hf, Hg, K, La, Li, Mg, Mn, Mo, Na, Ni, P, Rb, S, Sb, Se, Si, Sn, Sr, Ti, U, V, W, Zn, and Zr). MTPs water bodies are of bicarbonate dominant type, and a fresh meteoric water origin is suggested. The main pressures identified were grazing and trampling by vehicles. MTPs of Mt. Oiti were classified according to their ecological status form excellent to medium. Our results can contribute to a better understanding of the mountainous temporary ponds development in the Mediterranean environment.

AIM OF THE STUDY: To investigate the association of personality traits with the severity of vasomotor symptoms (VMS) in a predominantly Greek population. MATERIAL AND METHODS: A questionnaire-based study of women from the Menopause Clinic of a University Hospital in Athens, Greece. Sociodemographic parameters were documented through a structured interview. All women completed the Menopause Rating Scale (MRS) for the assessment of severity of menopausal symptoms, the Hot Flush Beliefs Scale (HFBS) for the assessment of how women were coping with their symptoms and the Big Five Inventory questionnaires for the assessment of personality traits. Associations between baseline parameters and menopausal symptoms were assessed with univariate and multivariate regression analyses. RESULTS: One hundred women were included. Employed women had lower MRS sub-scores (psychological p< 0.001, somatic p< 0.047, urogenital p< 0.008). Married women scored higher in the psychological and somatic domains. Women of university educational level coped significantly better with hot flushes (β coefficient [SE]: 0.72 [0.25], p< 0.01) and night sweats (0.57 [0.19], p< 0.01) than women of primary education, although the significance of these findings was not replicated when taking into account confounders. Regarding personality traits, women with low openness (-0.33 [0.11], p< 0.01) and empathy (-0.83 [0.37], p = 0.03) and high agreeableness (1.13 [0.21], p< 0.001) had more severe menopausal symptoms. In contrast, women with high agreeableness could better cope with their menopausal symptoms (-0.75 [0.36], p = 0.04). These associations were independent of sociodemographic factors. CONCLUSIONS: Personality traits, especially agreeableness, openness and empathy are associated with menopausal symptoms and functionality in postmenopausal women. These associations might serve as indicators of women at risk of experiencing more severe VMS.

We report an analysis of the first known β Cep pulsator observed by the Transiting Exoplanet Survey Satellite (TESS) mission, the runaway star PHL 346 = HN Aqr. The star, previously known as a singly periodic pulsator, has at least 34 oscillation modes excited, 12 of those in the g-mode domain and 22 p modes. Analysis of archival data implies that the amplitude and frequency of the dominant mode and the stellar radial velocity were variable over time. A binary nature would be inconsistent with the inferred ejection velocity from the Galactic disk of 420 km s-1, which is too large to be survivable by a runaway binary system. A kinematic analysis of the star results in an age constraint (23 ± 1 Myr) that can be imposed on asteroseismic modeling and that can be used to remove degeneracies in the modeling process. Our attempts to match the excitation of the observed frequency spectrum resulted in pulsation models that were too young. Hence, asteroseismic studies of runaway pulsators can become vital not only in tracing the evolutionary history of such objects, but to understand the interior structure of massive stars in general. TESS is now opening up these stars for detailed asteroseismic investigation.

Augmented reality (AR) comprises special hardware and software, which is used in order to offer computer-processed imaging data to the surgeon in real time, so that real-life objects are combined with computer-generated images. AR technology has recently gained increasing interest in the surgical practice. Preclinical research has provided substantial evidence that AR might be a useful tool for intra-operative guidance and decision-making. AR has been applied to a wide spectrum of orthopedic procedures, such as tumor resection, fracture fixation, arthroscopy, and component's alignment in total joint arthroplasty. The present study aimed to summarize the current state of the application of AR in orthopedics, in preclinical and clinical level, providing future directions and perspectives concerning potential further benefits from this technology.

BACKGROUND: The classification of hepatitis viruses still predominantly relies on ad hoc criteria, i.e., phenotypic traits and arbitrary genetic distance thresholds. Given the subjectivity of such practices coupled with the constant sequencing of samples and discovery of new strains, this manual approach to virus classification becomes cumbersome and impossible to generalize. METHODS: Using two well-studied hepatitis virus datasets, HBV and HCV, we assess if computational methods for molecular species delimitation that are typically applied to barcoding biodiversity studies can also be successfully deployed for hepatitis virus classification. For comparison, we also used ABGD, a tool that in contrast to other distance methods attempts to automatically identify the barcoding gap using pairwise genetic distances for a set of aligned input sequences. RESULTS—DISCUSSION: We found that the mPTP species delimitation tool identified even without adapting its default parameters taxonomic clusters that either correspond to the currently acknowledged genotypes or to known subdivision of genotypes (subtypes or subgenotypes). In the cases where the delimited cluster corresponded to subtype or subgenotype, there were previous concerns that their status may be underestimated. The clusters obtained from the ABGD analysis differed depending on the parameters used. However, under certain values the results were very similar to the taxonomy and mPTP which indicates the usefulness of distance based methods in virus taxonomy under appropriate parameter settings. The overlap of predicted clusters with taxonomically acknowledged genotypes implies that virus classification can be successfully automated.

We consider singular foliations whose holonomy groupoid may be nicely decomposed using Lie groupoids (of unequal dimension). We show that the Baum-Connes conjecture can be formulated in this setting. This conjecture is shown to hold under assumptions of amenability. We examine several examples that can be described in this way and make explicit computations of their K-theory.

The recent impact of the Biopharmaceutics Classification System (BCS) and the Biopharmaceutics Drug Disposition Classification System (BDDCS) on relevant scientific advancements is discussed. The major advances associated with the BCS concern the extensive work on dissolution of poorly absorbed BCS class II drugs in nutritional liquids (e.g. milk, peanut oil) and biorelevant media for the accurate prediction of the rate and the extent of oral absorption. The use of physiologically based pharmacokinetic (PBPK) modeling as predictive tool for bioavailability is also presented. Since recent dissolution studies demonstrate that the two mechanisms (diffusion- and reaction-limited dissolution) take place simultaneously, the neglected reaction-limited dissolution models are discussed, regarding the biopharmaceutical classification of drugs. Solubility- and dissolution-enhancing formulation strategies based on the supersaturation principle to enhance the extent of drug absorption, along with the applications of the BDDCS to the understanding of disposition phenomena are reviewed. Finally, recent classification systems relevant either to the BCS or the BDDCS are presented. These include: i) a model independent approach based on %metabolism and the fulfilment (or not) of the current regulatory dissolution criteria, ii) the so called AB Gamma system, a continuous version of the BCS, and iii) the so-called Extended Clearance Classification System (ECCS). ECCS uses clearance concepts (physicochemical properties and membrane permeability) to classify compounds and differentiates from BDDCS by bypassing the measure of solubility (based on the assumption that since it inter-correlates with lipophilicity, it is not directly relevant to clearance mechanisms or elimination).

Νumerous attempts have been made to explain and classify Bitcoin. The different opinions of eminent economists on the subject have raised a series of questions: What is the public’s notion of the digital currency? Would a general use of a digital currency be acceptable and if so, what kind of use would that be? Does the view of the experts on the subject conform with that of the layman individual? Our goal is to find out if the view of the public coincides with theopinion of the experts on the subject and to determine if is information can be implemented in order to establish a use of Bitcoin in our everyday lives, apart from the specialized use it has to date. During the first stage of this research, methods and rules of analysis such as descriptive statistics and tables and charts were used. Firstly, a questionnaire was used and secondly, the answers were gathered, classified and added up according to the participants’ choices. During the second stage the data was collected with the use of randomsampling, while various techniques, such as simple and multiple regressions were utilized for analyzing the results. The conclusion which has been obtained is that the public perceives Bitcoin differently than the experts do. Individuals believe that Bitcoin is mainly a means of transactions/payments, contrary to the experts’ opinion, which is that it is foremost an investment asset. Additionally, we may perceive a convergence between the view of public and that of the experts on the adoption of Bitcoin technology by existing trading systems.

Despite significant progress by genome-wide association studies, the ability of genetic variants to conduce to the prediction or prognosis of type-2 diabetes (T2D) is weak. Expression analysis of the corresponding genes may suggest possible links between single-nucleotide polymorphisms and T2D phenotype and/or risk. Herein, we investigated the expression patterns of 24 T2D-susceptibility genes, and their individual transcript variants (tv), in peripheral blood of T2D patients and controls (CTs), applying RNA-seq and real-time qPCR methodologies, and explore possible associations with disease features. Our data revealed the deregulation of certain transcripts in T2D patients. Among them, the down-regulation of CAPN10 tv3 was confirmed as an independent predictor for T2D. In patients, increased expression of CDK5 tv2, CDKN2A tv3 or THADA tv5 correlated positively with serum insulin levels, of CDK5 tv1 positively with % HbA1c levels, while in controls, elevated levels of TSPAN8 were associated positively with the presence of T2D family history. Herein, a T2D-specific expression profile of specific transcripts of disease-susceptibility genes is for the first time described in human peripheral blood. Large-scale studies are needed to evaluate the potential of these molecules to serve as disease biomarkers.

Archaeological remains are valuable relative sea-level (RSL) indicators in Israel, a tectonically stable coast with minor isostatic inputs. Previous research has used archaeological indicators to argue for centennial sea-level fluctuations. Here, we place archaeological indicators in a quality-controlled dataset where all indicators have consistently calculated vertical and chronological uncertainties, and we subject the data to statistical analysis. We combine the archaeological data with bio-construction data from Dendropoma petraeum colonial vermetids. The final dataset consists of 99 relative sea-level index points and 12 limiting points from the last 4000 a. The temporal distribution of the index points is uneven; Israel has only four index points before 2000 a BP. We apply an Errors-In-Variables Integrated Gaussian Process (EIV IGP) to the index points to model the evolution of RSL. Results show RSL in Israel rose from −0.8 ± 0.5 m at ∼2750 a BP (Iron Age) to 0.0 ± 0.1 m by ∼1850 a BP (Roman period) at 0.8 mm/a, and continued rising to 0.1 ± 0.1 m until ∼1600 a BP (Byzantine Period). RSL then fell to −0.3 ± 0.1 m by 0.5 mm/a until ∼650 a BP (Late Arab period), before returning to present levels at a rate of 0.4 mm/a. The re-assessed Israeli record supports centennial-scale RSL fluctuations during the last 3000 a BP, although the magnitude of the RSL fall during the last 2000 a BP is 50% less. The new Israel RSL record demonstrates correspondence with regional climate proxies. This quality-controlled Israeli RSL dataset can serve as a reference for comparisons with other sea-level records from the Eastern Mediterranean.

BACKGROUND: Cardiosphere-derived cells (CDCs) have yielded promising efficacy signals in early-phase clinical trials of ischemic and nonischemic cardiomyopathy. The potential efficacy of CDCs in acute myocarditis, an inflammatory cardiomyopathy without effective therapy, remains unexplored. Given that CDCs produce regenerative, cardioprotective, anti-inflammatory, and anti-fibrotic effects (all of which could be beneficial in acute myocarditis), we investigated the efficacy of intracoronary delivery of CDCs in a rat model of experimental autoimmune myocarditis. METHODS: Lewis rats underwent induction of experimental autoimmune myocarditis by subcutaneous footpad injection of purified porcine cardiac myosin supplemented with Mycobacterium tuberculosis on days 1 and 7. On day 10, rats were randomly assigned to receive global intracoronary delivery of 500 000 CDCs or vehicle. Global intracoronary delivery was performed by injection of cells or vehicle into the left ventricular (LV) cavity during transient occlusion of the aortic root. Rats were euthanized 18 days after infusion. Cardiac volumes and systolic function were assessed by serial echocardiography, performed on days 1, 10, and 28. Myocardial inflammation, T-cell infiltration, and cardiac fibrosis were evaluated by histology. RESULTS: Experimental autoimmune myocarditis was successfully induced in 14/14 rats that completed follow-up. Left ventricular ejection fraction (LVEF) and volumes were comparable on days 1 and 10 between groups. CDC infusion resulted in increased LVEF (81.5% +/- 3% vs 65.4% +/- 8%, P < .001) and decreased LV end-systolic volume (43 +/- 15 vs 100 +/- 24 muL, P < .001) compared to placebo administration at 18 days post-infusion. Cardiosphere-derived cell infusion decreased myocardial inflammation (7.4% +/- 7% vs 20.7% +/- 4% of myocardium, P = .007), cardiac fibrosis (16.6% +/- 13% vs 38.1% +/- 3% of myocardium, P = .008), and myocardial T-cell infiltration (30.4 +/- 29 vs 125.8 +/- 49 cells per field, P = .005) at 18 days post-infusion compared to placebo administration. CONCLUSION: Intracoronary delivery of CDCs attenuates myocardial inflammation, T-cell infiltration, and fibrosis while preventing myocarditis-induced systolic dysfunction and adverse remodeling in rats with experimental autoimmune myocarditis.

Longitudinal stability of the forearm is mainly provided by three structures: the radiocapitellar contact, which acts as the primary stabilizer, the central band of the interosseous ligamentous complex (IOLC) and the intact triangular fibrocartilage complex (TFCC). In an Essex-Lopresti lesion the forearm becomes fully destabilized, since all of these three components are injured. Fixation or replacement of the radial head with a metallic prosthesis along with repair of the TFCC and stabilization of the distal radioulnar joint (DRUJ) are well-established treatment goals. However the reconstruction of the central band of the IOLC remains to some extent controversial. The authors believe that the reconstruction of the central band, particularly in active patients, is crucial in order to restore normal load distribution through the forearm, thus ensuring both transverse and longitudinal stability. In this article, we present a case with an Essex-Lopresti lesion, which was effectively treated acutely with restoration of all three components of the injury (radial head prosthesis, DRUJ repair and reconstruction of the central band of the IOLC). A novel technique by rerouting the brachioradialis tendon is described in detail.

From a large screening of microbial extracts for the discovery of proteasome modulating natural products, the fungal strain Cercospora sp. (CF-223709) was selected as the most promising for further investigation. Different liquid cultures of the strain were initially screened for their anti-oxidant activity (DPPH, ABTS) and for their cytotoxicity against the A2058, HepG2 and CCD25sk cell lines. A detailed chemical analysis and evaluation of the capacity to activate 26S-proteasome was followed for the most active extract. Three main polyketides were isolated and characterized by extensive analysis of NMR and HRMS spectra data as penialidine F (1), fulvic acid (2), and SB238569 (3). Fulvic acid showed the most significant anti-oxidant activity. Its IC50 value (8.16 $μ$M) against the ABTS radical resulted 3-fold lower than the standard trolox. Fulvic acid also demonstrated a significant effect on proteasome by enhancing the chymotrypsin- and caspase-like activities of the 26S proteasome of human fibroblasts by 71.43{%} and 37.5{%} at 1 $μ$M, respectively. Furthermore by scaling up the culture in a 30 L submerged bioreactor, Cercospora sp. produced up to 162.6 ± 1.3 mg of fulvic acid/L. Our findings suggest that CF-223709 can be a promising source of proteasome activating natural compounds.

In this article we examine patterns of root allomorphy in Greek that involve vowel alternations and propose a Generalized Non-linear Affixation (Bermúdez-Otero 2012) analysis according to which these alternations result from the competition between segments that belong, on the one hand, to the vocabulary items of roots and, on the other, to the exponents of functional heads (Voice/Aspect, n). More specifically, we claim that phonological entities have a gradient degree of presence in a structure, that is, are specified with a certain activation strength value underlyingly (Smolensky and Goldrick 2016). As a result, the surface realization of roots is determined by the relevant activation level of the exponents of functional heads they are eventually combined with. From all available exponents, the one that optimally complements the strength value of the vocabulary item of a given root will eventually surface. Our analysis is shown to be theoretically advantageous because it develops a strictly phonological account of allomorphy and, moreover, it captures the attested generalizations without resorting to extensive stem/span listing or to the application of phonologically unrestricted readjustment rules.

Economic growth and social evolution are  connected to trust relationships in a society. The quality of the accounting information, the tax information system and the tax audit mechanism evolve multiple benefits in an economy. Tax evasion, the illegal practice where people and companies do not pay taxes, is a crime because of the negative effect in economy and society. In this paper, we describe a theoretical framework on the characteristics of a fair and efficient tax auditing information system which could be a tool against tax evasion, a tool for an economy to grow, especially in countries that face fluctuations in economic activity. We conclude that a fair and efficient tax auditing information system increases the reliability of tax administration, improves taxpayers’ tax compliance and causes a developmental trajectory for the economy.

Chronic stress, a suggested precipitant of brain pathologies, such as depression and Alzheimer's disease, is known to impact on brain plasticity by causing neuronal remodeling as well as neurogenesis suppression in the adult hippocampus. Although many studies show that stressful conditions reduce the number of newborn neurons in the adult dentate gyrus (DG), little is known about whether and how stress impacts on dendritic development and structural maturation of these newborn neurons. We, herein, demonstrate that chronic stress impacts differentially on doublecortin (DCX)-positive immature neurons in distinct phases of maturation. Specifically, the density of the DCX-positive immature neurons whose dendritic tree reaches the inner molecular layer (IML) of DG is reduced in stressed animals, whereas their dendritic complexity is increased. On the contrary, no change on the density of DCX-positive neurons whose dendritic tree extends to the medial/outer molecular layer (M/OML) of the DG is found under stress conditions, whereas the dendritic complexity of these cells is diminished. In addition, DCX+ cells displayed a more complex and longer arbor in the dendritic compartments located in the granular cell layer of the DG under stress conditions; on the contrary, their dendritic segments localized into the M/OML were shorter and less complex. These findings suggest that the neuroplastic effects of chronic stress on dendritic maturation and complexity of DCX+ immature neurons vary based on the different maturation stage of DCX-positive cells and the different DG sublayer, highlighting the complex and dynamic stress-driven neuroplasticity of immature neurons in the adult hippocampus.

Chronic stress, a suggested precipitant of brain pathologies, such as depression and Alzheimer's disease, is known to impact on brain plasticity by causing neuronal remodeling as well as neurogenesis suppression in the adult hippocampus. Although many studies show that stressful conditions reduce the number of newborn neurons in the adult dentate gyrus (DG), little is known about whether and how stress impacts on dendritic development and structural maturation of these newborn neurons. We, herein, demonstrate that chronic stress impacts differentially on doublecortin (DCX)-positive immature neurons in distinct phases of maturation. Specifically, the density of the DCX-positive immature neurons whose dendritic tree reaches the inner molecular layer (IML) of DG is reduced in stressed animals, whereas their dendritic complexity is increased. On the contrary, no change on the density of DCX-positive neurons whose dendritic tree extends to the medial/outer molecular layer (M/OML) of the DG is found under stress conditions, whereas the dendritic complexity of these cells is diminished. In addition, DCX+ cells displayed a more complex and longer arbor in the dendritic compartments located in the granular cell layer of the DG under stress conditions; on the contrary, their dendritic segments localized into the M/OML were shorter and less complex. These findings suggest that the neuroplastic effects of chronic stress on dendritic maturation and complexity of DCX+ immature neurons vary based on the different maturation stage of DCX-positive cells and the different DG sublayer, highlighting the complex and dynamic stress-driven neuroplasticity of immature neurons in the adult hippocampus.

Introduction: The identification of novel noninvasive biomarkers to ameliorate early-diagnosis, and disease prognosis, as well as to support personalized treatment and monitoring decisions is of first clinical priority for cancer patients' care. Exosomes are natural endosome-derived extracellular vesicles that have emerged as crucial mediators of intercellular communication and tumor progression. Considering that deregulated miRNA levels have been described in numerous human malignancies and that tumor-derived exosomes reflect miRNA expression of donor tumor cells, the evaluation of exosome-derived circulating miRNAs (exomiRs) may offer a new promising class of noninvasive molecular markers to improve patients' management and quality-of-life. Areas covered: In the current review we have summarized the existing knowledge on the clinical relevance of circulating exosomal miRNAs in improving cancer diagnosis and prognosis, and thus supporting personalized patients' management Expert commentary: Cancer research has highlighted the abundance of exomiRs in patients' plasma and serum samples, as well as their biomarker capabilities in the vast majority of human malignancies studied so far. Their analytical stability constitutes exomiRs ideal molecular markers to overcome numerous limitations of cancer clinical management, while future large-scale studies should unveil exomiRs translational utility in modern cancer molecular diagnostics.

Almost all confirmed optical counterparts of HMXBs in the SMC are OB stars with equatorial decretion disks (OBe). These sources emit strongly in Balmer lines and standout when imaged through narrow-band Hα imaging. The lack of secure counterparts for a significant fraction of the HMXBs motivated us to search for more. Using the catalogs for OB/OBe stars (Maravelias et al. 2017) and for HMXBs (Haberl & Sturm 2016) we detect 70 optical counterparts (out of 104 covered by our survey). We provide the first identification of the optical counterpart to the source XTEJ0050-731. We verify that 17 previously uncertain optical counterparts are indeed the proper matches. Regarding 52 confirmed HMXBs (known optical counterparts with Hα emission), we detect 39 as OBe and another 13 as OB stars. This allows a direct estimation of the fraction of active OBe stars in HMXBs that show Hα emission at a given epoch to be at least ˜75% of their total HMXB population.