Publications

This study addresses the utility of pharmacodynamic considerations to the assessment of bioequivalence (BE) studies. A novel methodology was developed and the performance of classic, nonclassic and novel BE indices was evaluated using extensive simulations of BE trials generated from a classic pharmacokinetic (PK)/pharmacodynamic (PD) model. Three novel indices based on drug's pharmacodynamics were developed and served as criteria for the assessment of all BE indices. Modified power curves were constructed and used for the analysis of BE trials from a PD point of view. All BE indices of either purely PK or PD nature were classified in a semiquantitative manner according to their strictness in declaring BE. The partial area until the peak concentration followed by the two newly proposed metrics (MARD, MARD(w1)) exhibited the most strict performance in declaring BE irrespective of the PK scenarios examined. The study opens new avenues in BE assessment since it places more emphasis on the PD aspects of the formulations. (C) 2003 Elsevier Science B.V. All rights reserved.

Background: This multicenter, prospective phase II study evaluated the safety and efficacy of the combination of docetaxel and vinorelbine in patients with platinum-resistant, paclitaxel-pretreated recurrent ovarian cancer. Patients and methods: Treatment consisted of vinorelbine 25 mg/m2 as a 20-min i.v. infusion (days 1 and 8), and docetaxel 70 mg/m2, as a 1-h i.v. infusion (day 8). Granulocyte colony-stimulating factor support was administered prophylactically on days 12-16. Treatment was repeated every 21 days. Results: Forty-six patients were enrolled. The median number of previous chemotherapeutic regimens was one (range 1-3) with a median treatment-free interval of 4.3 months. Four chemotherapy cycles per patient were administered. Almost 75% of the planned doses for both drugs were given. Forty-one patients are evaluable for response. Three patients (6.5% of all patients; 7.3% of evaluable patients) achieved complete response and eight (17.4% and 19.5%, respectively) a partial response to chemotherapy leading to overall response rates of 23.9% and 26.8%, respectively. Another 34.8% (39.0%) had stable disease. At a median follow-up of 30 months, the median disease-free survival was 13 months, relapse-free survival was 5 months, time to progression was 4.5 months, and overall survival was 9.3 months. Severe toxicities included leukopenia (31%), neutropenia (35%) and febrile neutropenia (20%). Conclusions: The combination of docetaxel/vinorelbine is an effective regimen with manageable toxicity for the treatment of platinum-resistant, paclitaxel-pretreated ovarian cancer.

The paper presents combined spectroscopic and photometric orbital solutions for four close binary systems: SW Lyn, QW Gem, AP Leo and V2150 Cyg. The photometric data are new, while the spectroscopy has been recently obtained within the radial velocity programme at the David Dunlap Observatory. This paper is the first in the planned series of investigations. We give an extensive description of the motivation for the series and of the main assumptions made in our solutions. The four targets of this investigation span a range of typical configurations and thus present different levels of difficulty for the combined spectroscopic and photometric orbital solutions.

The purposes of this study were to (i) re-examine the relevance of Higuchi equation and the power la Using both simulated and experimental release data in conjunction with the linearized. in tern's of t(1/2). percent of drug release plots. (ii) demonstrate that the power law describes the entire drug release profile of several experimental data, and (iii) point out a physically based hypothesis for the Successful Use Of power law in describing the entire drug release profile. Simulated data generated from the equation of power law were further analyzed using linear regression analysis in accord with the Higuchi equation. The analysis revealed that data generated from the equation Of power law can be misinterpreted as obeying the Higuchi equation. The use of power law in describing the entire drug release curie from HPMC-based matrix tablets is validated by direct fit of power law equation to published data of other authors. A hypothesis based on the nonclassical diffusion of the solutes in the HPMC matrices is used to interpret the successful use of the power law in describing the entire release profile. (C) 2003 Elsevier Science B.V, All rights reserved.

In order to investigate the potential relationship between erythromycin resistance and specific M-serotypes among clinical isolates of Streptococcus pyogenes from children in Greece, we randomly selected a total of 49 erythromycin-resistant (EryR) and 21 erythromycin-susceptible (EryS) isolates from the 1158 S. pyogenes isolates from the two main children's hospitals of Athens during the period October 1997 to October 1998. The isolates were further characterized by M-serotyping, examined for their susceptibility to penicillin, vancomycin and clindamycin, and categorized into resistance phenotypes. A total of 248 (21%) S. pyogenes isolates in the two main children's hospitals of Athens during the study period were resistant to erythromycin. All 49 EryR and 21 EryS isolates were susceptible to penicillin and vancomycin. With respect to erythromycin and clindamycin resistance, phenotypes M and IR MLSB dominated, with 30 and 17 isolates, respectively, two isolates belonged to the CR MLSB phenotype. Among the erythromycin resistant isolates, two M serotypes were dominant: M22 (30%) and M84 (41%). More specifically, M22 and M84 were most prevalent in resistance phenotypes IR MLSB (65%) and M (63%), respectively. In the susceptible group, no isolate belonged to these two M-serotypes, nor was a predominant serotype found. In contrast to susceptible isolates, two distinct M-serotypes were highly represented among EryR S. pyogenes isolates and predominantly associated with two distinct phenotypes.

The presence of erm genes conferring constitutive and inducible resistance, as well as that of the mefA gene conferring only constitutive resistance, was investigated using PCR in 70 erythromycin resistant (MIC>or=1 mg/l) strains of viridans group streptococci (VGS) (18 Streptococcus mitis biotype 1, 16 S. mitis biotype 2, 15 S. oralis, 12 S. salivarius and nine S. sanguis) isolated from the oropharynx of healthy Greek children. All of the 56 isolates belonging to resistance phenotype M harbored the mefA gene. All of the 14 isolates constitutively resistant to macrolides and lincosamides (phenotype CR) harbored the ermB gene. Co-presence of both genes was not observed, whereas class A erm gene (previously known as ermTR) was not detected. Our results are consistent with a possible role of VGS as a reservoir of resistance genes now prevalent in pathogenic species of streptococci.

Objectives. To study retrospectively CA 125, CD44, and epithelial membrane antigen (EMA) expression in renal cell carcinoma and their role as prognostic factors. CD44 is a cell adhesion molecule, and CA 125 and EMA are tumor-associated antigens used in the diagnosis and monitoring of the outcome and response to treatment of various human malignancies. Their expression and prognostic significance after resection of renal cell carcinoma have not been adequately studied. Methods. The expression of CA 125, CD44, and EMA were studied immunohistochemically and correlated with the outcome of 92 patients who underwent nephrectomy for renal cell carcinoma. Results. Positive staining was found for CA 125 in 28 patients (30.43%), CD44 in 48 patients (52.17%), and EMA in 74 patients (80.43%). CA 125 expression was increased in those with higher T stage (P <0.001) and histologic grade (P = 0.007). An inverse relationship was found between EMA expression and grade (P <0.001). The median follow-up was 41.5 months (range 30 to 65). The median survival for positive and negative patients was 34.6 versus 54.3 months for CA 125 (P = 0.0044), 48.3 versus 51.5 months for CD44 (P = 0.4677), and 53.2 versus 34 months for EMA (P = 0.0046). Multivariate analysis showed that CA 125 and EMA expression were independent prognostic factors (P = 0.021 and P = 0.018, respectively). Subgroup analysis showed that CA 125 expression predicted a significantly higher probability of death (28.6% versus 8%, P =0.0413) in patients with T1 or T2 tumors. Conclusions. CA 125 and EMA appear to be useful prognostic markers in renal cell carcinoma. Additional studies are needed to determine the value of these markers as a means of selection for postoperative management. © 2003 Elsevier Inc.

BACKGROUND: Activation of T lymphocytes is thought to mediate myocardial dysfunction in dilated cardiomyopathy (CMP), probably through cytotoxic cytokines, but its value as a prognostic factor has not been evaluated. METHODS: For 2 years we prospectively followed 76 patients (65 males, 11 females, age 49 +/- 7 years) with CMP and New York Heart Association(NYHA) Class II-III heart failure; left ventricular (LV) function was assessed echocardiographically. Thirty-three patients (28 males, five females, age 52 +/- 6 years) with ischaemic heart disease (IHD) and similar NYHA and LV function characteristics were used as controls. Serum sIL-2R levels, peripheral blood lymphocyte proliferation (basal, + concanavalin A) and HLA-DQB1 genotyping was carried out in all patients. RESULTS: The CMP patients had increased sIL-2R levels (1259 +/- 130 pg mL-1) compared with the IHD patients (703 +/- 80 pg mL-1, P < 0.01, only 3 > 800 pg mL-1). In the CMP patients, there was a significant (r = +0.45, P= 0.04) correlation between sIL-2R and the LV end-diastolic diameter but not with the LV ejection fraction or NYHA Class. During the 24-month follow up, 17 of the CMP patients had an adverse clinical course (death, need for cardiac transplantation, or worsening heart failure). Of these, 14 (75%) had elevated (>or= 800 pg mL-1) sIL-2R levels (Group I) compared with only five (6%) with a stable clinical course (Group II). Neither [3H] thymidine incorporation into the peripheral blood lymphocytes nor the excess of HLA-DQB1-30 histidine homozygotes in the Group I patients (38% vs. 17%, P < 0.05) could predict the clinical outcome. CONCLUSION: Increased sIL-2R levels in CMP patients are an independent predictor of a more aggressive clinical course

Background: The combination of vincristine and doxorubicin administered as a continuous infusion via an indwelling catheter together with intermittent high-dose dexamethasone (VAD) is an effective primary treatment for patients with symptomatic multiple myeloma. In order to avoid the need for an indwelling catheter, which imposes logistic problems for outpatient administration, several phase II studies have explored the feasibility and efficacy of VAD-like outpatient regimens. We designed a prospective randomized study to compare the objective response rates of two VAD-like outpatient regimens as primary treatment for symptomatic patients with multiple myeloma. Patients and methods: Patients were entered in a randomized study regardless of age, performance status and renal function. One hundred and twenty-seven patients received VAD bolus, which consisted of vincristine 0.4 mg i.v., doxorubicin 9 mg/m2 i.v. and dexamethasone 40 mg p.o. daily for four consecutive days and 132 patients received VAD doxil, which consisted of vincristine 2 mg i.v. and liposomal doxorubicin 40 mg/m2 i.V. on day 1 and dexamethasone 40 mg p.o. daily for 4 days. The two regimens were administered every 28 days for four courses and in courses 1 and 3, in both arms, dexamethasone was also given on days 9-12 and 17-20. Results: An objective response was documented in 61.4% and 61.3% of patients treated with VAD bolus and VAD doxil, respectively. Hematological and non-hematological toxicities were mild or moderate and equally distributed between the two treatment arms with the exception of alopecia, which was more common after VAD bolus, and of palmar-plantar erythrodysesthesia, which was more common after VAD doxil. Conclusions: Our multicenter trial, which included an unselected patient population, indicated that both VAD bolus and VAD doxil can be administered to outpatients and can provide an equal opportunity of rapid response in many patients with multiple myeloma.

Το βιβλίο "Φιλοσοφικές έννοιες στη Φυσική" παρουσιάζει την ανάπτυξη της επιστήμης της Φυσικής σε σχέση με το ιστορικό και φιλοσοφικό πλαίσιο μέσα στο οποίο αυτή συντελέστηκε.Μέσα από τις σελίδες του, δίνεται η ευκαιρία στον αναγνώστη να στοχαστεί σχετικά με τη φύση του επιστημονικού εγχειρήματος την οποία μπορεί να είχε προσεγγίσει νωρίτερα μέσα από το πρίσμα της παραδοσιακής ιστορίας της επιστήμης και μέσα από μια σειρά μαθημάτων στις φυσικές επιστήμες.Στόχος του είναι να εντυπώσει στον αναγνώστη τον ουσιαστικό ρόλο τον οποίο έχουν διαδραματίσει οι φιλοσοφικές θεωρήσεις σε ό,τι αφορά την επιστημονική πρακτική και την κατασκευή των επιστημονικών θεωριών.Αντίθετα με την αρκετά διαδεδομένη άποψη ότι η Φυσική και η Φιλοσοφία είναι απομακρυσμένες η μία από την άλλη, αυτό το βιβλίο περιγράφει τη συνεχή αλληλεπίδραση που είχαν και συνεχίζουν να έχουν.Μέσα στις σελίδες του βιβλίου η συζήτηση για τα κύρια φιλοσοφικά ζητήματα εδράζεται στο συγκεκριμένο ιστορικό πλαίσιο και στο περιεχόμενο της αντίστοιχης επιστημονικής δραστηριότητας. [...]

Purpose. To develop a quantitative biopharmaceutics drug classification system (QBCS) based on fundamental parameters controlling rate and extent of absorption. Methods. A simple absorption model that considers transit flow, dissolution, and permeation processes stochastically was used to illustrate the primary importance of dose/solubility ratio and permeability on drug absorption. Simple mean time considerations for dissolution, uptake, and transit were used to identify relationships between the extent of absorption and a drug's dissolution and permeability characteristics. Results. The QBCS developed relies on a ( permeability, dose/ solubility ratio) plane with cutoff points 2 x 10(-6) - 10(-5) cm/s for the permeability and 0.5 - 1 (unitless) for the dose/ solubility ratio axes. Permeability estimates, P-app are derived from Caco-2 studies, and a constant intestinal volume content of 250 ml is used to express the dose/ solubility ratio as a dimensionless quantity, q. A physiologic range of 250 - 500 ml was used to account for variability in the intestinal volume. Drugs are classified into the four quadrants of the plane around the cutoff points according to their Papp, q values, establishing four drug categories, i.e., I (P-app > 10(-5) cm/s, q less than or equal to 0.5), II (P-app > 10(-5) cm/s, q > 1), III (P-app < 2 x 10(-6) cm/s, q <= 0.5), and IV (P-app < 2 x 10(-6) cm/s, q > 1). A region for borderline drugs (2 x 10(-6) < P-app < 10(-5) cm/s, 0.5 < q < 1) was defined too. For category I, complete absorption is anticipated, whereas categories II and III exhibit dose/ solubility ratio - limited and permeability-limited absorption, respectively. For category IV, both permeability and dose/ solubility ratio are controlling drug absorption. Semiquantitative predictions of the extent of absorption were pointed out on the basis of mean time considerations for dissolution, uptake, and transit in conjunction with drug's dose/ solubility ratio and permeability characteristics. A set of 42 drugs were classified into the four categories, and the predictions of intestinal drug absorption were in accord with the experimental observations. Conclusions. The QBCS provides a basis for compound classification into four explicitly defined drug categories using the fundamental biopharmaceutical properties, permeability, and dose/ solubility ratio. Semiquantitative predictions for the extent of absorption are essentially based on these drug properties, which either determine or are strongly related to the in vivo kinetics of drug dissolution and intestinal wall permeation.

This study, explores the utility of quantitative structure-pharmacokinetic relationship models of the disposition parameters: clearance (CL), apparent volume of drug distribution (V-ap), fractal clearance (CLf), and fractal volume (v(f)), for a series of 23 cephalosporins used in therapeutics. Data for CL, V-ap and elimination half-life were obtained from literature, whereas CL, and vf were calculated from the literature data for CL and V-ap, respectively. A variety of descriptors expressing acidity/basicity, lipophilicity, molecular size and hydrogen bonding properties were estimated using computer packages. For each pharmacokinetic parameter, projection to latent structures (PLS) was applied to the total dataset. Adequate PLS models, with one principal component, were derived for CL, CLf, V-ap and v(f). Identical descriptors were found to be significant for the two clearance as well as for the two volume of distribution terms. CL and CLf expressed similar performance while the predictive performance of v(f) was much higher than that of V-ap. Multiple linear and non-linear regression models were developed. The regression results were in agreement with the PLS models. The non-linear models were superior to the relevant linear relationships. The worst models found were for V-ap (R-2 = 0.523 and R-2 = 0.571 for the linear and non-linear model, respectively) and the best models found were for v(f) (R-2 = 0.729 and R-2 = 0.824 for the linear and non-linear model, respectively). (C) 2003 Elsevier B.V. All fights reserved.

A randomized trial was conducted to assess the efficacy of daily (QD) or thrice weekly (TIW) administration of interferon-alpha (IFN) in high doses in combination with ribavirin (1.0-1.2 g/day) in patients with chronic hepatitis C (CHC) who were nonresponders to previous IFN monotherapy. Interferon was administered as 10 MU IFN (QD or TIW) for 4 weeks, followed by 5 MU IFN (QD or TIW) for 20 weeks, and then by 3 MU IFN (QD or TIW) for 24 weeks. Sustained virological response (SVR) was evaluated in 142 patients who received at least one dose of medication. One-fourth of the patients achieved SVR, 26% of those treated with IFN QD and 25% of those treated with IFN TIW (P = 0.85). For genotype 1 patients, SVR rates were 32.4 and 15.8% for IFN QD and IFN TIW, respectively, whereas for genotype non-1 patients the corresponding SVR rates were 20.6 and 36.4%, respectively (test of homogeneity: P = 0.031). This finding was further confirmed by multivariate logistic regression analysis where a statistically significant interaction (P = 0.012) was found between treatment and HCV genotype indicating that the IFN QD regimen was superior to IFN TIW among genotype 1 patients whereas, among genotype non-1 patients, the two treatments were similar (odds ratio of SVR in IFN QD vs IFN TIW: 3.33 among genotype 1 patients, 95% CI: 1.00-11.14). In conclusion, re-treatment of patients not responding to previous IFN monotherapy with a combination of high daily dose of IFN with ribavirin may be beneficial for genotype 1 infected patients.

A randomized trial was conducted to assess the efficacy of interferon-alpha (IFN) daily in combination with ribavirin in 301 naive patients with chronic hepatitis C (CHC). Patients were randomized to receive ribavirin 1.2 g daily (QD) for 48 weeks with either IFN 5 MU (thrice weekly) TIW for 8 weeks followed by IFN 3 MU TIW for 40 weeks (IFN TIW, n = 154) or IFN 5 MU QD for 8 weeks followed by IFN 3 MU QD for 16 weeks followed by IFN 3 MU TIW for 24 weeks (IFN QD, n = 147). Treatment discontinuation rates, because of adverse events, were similar in the two arms (14.9% in IFN TIW and 14.3% in IFN QD, P = 0.87). The proportion of patients with sustained virological response (SVR) was 27.9% for patients treated TIW and 38.8% for those treated QD (P = 0.046). According to logistic regression analysis, patients in the IFN QD arm had 1.7 times higher probability of achieving SVR, than those receiving IFN TIW (P = 0.038). Low baseline viral load (P = 0.017) and genotype non-1 (P = 0.036) were associated with higher SVR rates. Combination of IFN/ribavirin for 48 weeks is more effective when IFN is administered daily for the first 24 weeks in naive patients with CHC.

We demonstrate that a quantum-dot cellular automata device can be fabricated using electron beam lithographically defined gates on GaAs/AlGaAs heterostructure materials, and that by tuning the four quantum dot (J. Phys. C: Solid State Phys. 21 (1988) L893) system polarization of one double dot can lead to polarization in the neighboring double dot (Phys. Rev. B 67 (2003) 033302). The polarization is detected using a 1-D or 0-D channel defined next to one pair of double dots which acts as a non-invasive voltage probe (Phys. Rev. Lett. 70 (1993) 1311). Ultimately a cellular automata device should be isolated from reservoirs to prevent charge fluctuations caused by co-tunneling. The non-invasive voltage probe is used to show that coupled double dots isolated from reservoirs can be made to have a sharper polarization transition. By studying the broadening of the polarization signal from a coupled double dot system isolated from reservoirs, we deduce the charge dephasing times for intra dot scattering to be more than 0.2 ns (Phys. Rev. B 67 (2003) 073302). © 2004 Elsevier Ltd. All rights reserved.

Purpose. To verify the Higuchi law and study the drug release from cylindrical and spherical matrices by means of Monte Carlo computer simulation. Methods. A one-dimensional matrix, based on the theoretical assumptions of the derivation of the Higuchi law, was simulated and its time evolution was monitored. Cylindrical and spherical three-dimensional lattices were simulated with sites at the boundary of the lattice having been denoted as leak sites. Particles were allowed to move inside it using the random walk model. Excluded volume interactions between the particles was assumed. We have monitored the system time evolution for different lattice sizes and different initial particle concentrations. Results. The Higuchi law was verified using the Monte Carlo technique in a one-dimensional lattice. It was found that Fickian drug release from cylindrical matrices can be approximated nicely with the Weibull function. A simple linear relation between the Weibull function parameters and the specific surface of the system was found. Conclusions. Drug release from a matrix, as a result of a diffusion process assuming excluded volume interactions between the drug molecules, can be described using a Weibull function. This model, although approximate and semiempirical, has the benefit of providing a simple physical connection between the model parameters and the system geometry, which was something missing from other semiempirical models.

It is commonly accepted that shot put performance is mainly determined by the ability of the lower body to produce power. The purpose of the present study was to investigate the relationship between shot put performance and triceps brachii muscle fiber type composition and strength capacity. Thirteen male physical education students were selected to participate in the study based upon their shot put performance after 5 weeks of shot put technique instruction. At the completion of this technique-instruction period, they performed the following tests: shot put with a 6-kg shot, isokinetic torque measurements of the elbow extensors at 0, 0.52, 1.04, 1.57, 2.09, 3.14, and 4.19 rad.s(-1), maximal strength (1 RM) and explosive-throwing bench-press tests, one-arm seated shot put with 1-, 2-, 3-, 4-, 5- and 6-kg shot. Whole-body and dominant upper-arm bioimpedance measurements were used to estimate whole-body and upper-arm muscle mass. Muscle biopsy samples from the long head of the dominant triceps brachii were obtained and analyzed for fiber type composition with ATPase histochemistry. Shot put performance was significantly correlated with type II fiber area ( r=0.70, P<0.01), one-arm seated shot put (range r=0.60 to r=0.79, P<0.05), elbow extensors' isokinetic torque (range r=0.65 to r=0.78, P<0.05), bench-press tests ( r>0.86, P<0.01) and estimated arm muscle cross-sectional area ( r=0.68, P<0.05). These results suggest that fiber type composition and the functional capacity of triceps brachii muscle (e.g., isokinetic torque) explain a part of shot put performance. The magnitude of the correlation coefficients between shot put and the upper-body power tests suggests that other body parts (e.g., lower extremities) may play a significant role in this event.

We present exact radially self-similar solutions of special relativistic magnetohydrodynamics representing ``hot'' super-Alfvénic outflows from strongly magnetized, rotating compact objects. We argue that such outflows can plausibly arise in gamma-ray burst (GRB) sources and demonstrate that, just as in the case of the trans-Alfvénic flows considered in the companion paper, they can attain Lorentz factors that correspond to a rough equipartition between the Poynting and kinetic energy fluxes and become cylindrically collimated on scales compatible with GRB observations. As in the trans-Alfvénic case, the initial acceleration is thermal, but, in contrast to the solutions presented in the companion paper, part of the enthalpy flux is transformed into Poynting flux during this phase. The subsequent, magnetically dominated acceleration can be significantly less rapid than in trans-Alfvénic flows.

We present a general formulation of special relativistic magnetohydrodynamics and derive exact radially self-similar solutions for axisymmetric outflows from strongly magnetized, rotating compact objects. We generalize previous work by including thermal effects and analyze in detail the various forces that guide, accelerate, and collimate the flow. We demonstrate that, under the assumptions of a quasi-steady poloidal magnetic field and of a highly relativistic poloidal velocity, the equations become effectively time independent and the motion can be described as a frozen pulse. We concentrate on trans-Alfvénic solutions and consider outflows that are super-Alfvénic throughout in the companion paper. Our results are applicable to relativistic jets in gamma-ray burst (GRB) sources, active galactic nuclei, and microquasars, but our discussion focuses on GRBs. We envision the outflows in this case to initially consist of a hot and optically thick mixture of baryons, electron-positron pairs, and photons. We show that the flow is at first accelerated thermally but that the bulk of the acceleration is magnetic, with the asymptotic Lorentz factor corresponding to a rough equipartition between the Poynting and kinetic energy fluxes (i.e., ~50% of the injected total energy is converted into baryonic kinetic energy). The electromagnetic forces also strongly collimate the flow, giving rise to an asymptotically cylindrical structure.

We present exact radially self-similar solutions of special relativistic magnetohydrodynamics representing ``hot'' super-Alfvénic outflows from strongly magnetized, rotating compact objects. We argue that such outflows can plausibly arise in gamma-ray burst (GRB) sources and demonstrate that, just as in the case of the trans-Alfvénic flows considered in the companion paper, they can attain Lorentz factors that correspond to a rough equipartition between the Poynting and kinetic energy fluxes and become cylindrically collimated on scales compatible with GRB observations. As in the trans-Alfvénic case, the initial acceleration is thermal, but, in contrast to the solutions presented in the companion paper, part of the enthalpy flux is transformed into Poynting flux during this phase. The subsequent, magnetically dominated acceleration can be significantly less rapid than in trans-Alfvénic flows.

We present a general formulation of special relativistic magnetohydrodynamics and derive exact radially self-similar solutions for axisymmetric outflows from strongly magnetized, rotating compact objects. We generalize previous work by including thermal effects and analyze in detail the various forces that guide, accelerate, and collimate the flow. We demonstrate that, under the assumptions of a quasi-steady poloidal magnetic field and of a highly relativistic poloidal velocity, the equations become effectively time independent and the motion can be described as a frozen pulse. We concentrate on trans-Alfvénic solutions and consider outflows that are super-Alfvénic throughout in the companion paper. Our results are applicable to relativistic jets in gamma-ray burst (GRB) sources, active galactic nuclei, and microquasars, but our discussion focuses on GRBs. We envision the outflows in this case to initially consist of a hot and optically thick mixture of baryons, electron-positron pairs, and photons. We show that the flow is at first accelerated thermally but that the bulk of the acceleration is magnetic, with the asymptotic Lorentz factor corresponding to a rough equipartition between the Poynting and kinetic energy fluxes (i.e., ~50% of the injected total energy is converted into baryonic kinetic energy). The electromagnetic forces also strongly collimate the flow, giving rise to an asymptotically cylindrical structure.

There are observational indications that relativistic outflows in AGNs are accelerated over distances that far exceed the scale of the central engine. Examples include the radio galaxy NGC 6251, where knots in the radio jets were inferred to accelerate from ~0.13c at a distance of ~0.53 pc from the galactic nucleus to ~0.42c at r=1.0 pc, and the quasar 3C 345, where the Lorentz factor of the radio knot C7 was deduced to increase from ~5 to >10 as it moved from r=3 pc to r=20 pc. It is argued, using exact semianalytic solutions of the relativistic MHD equations, that this behavior is a signature of magnetic acceleration. The same basic driving mechanism may apply to the relativistic jets in AGNs, gamma-ray burst sources, and microquasars.

This study describes the adaptation of the State-Trait Anxiety Inventory for Children (STAIC; Spielberger, Edwards, Lushene, Montuori, & Platzek, 1973) to the Greek population. It was hypothesized that the STAIC would be able to measure children’s state-trait anxiety levels. In the initial phase, a sample of 100 children, aged 9-12 years, was used in order to shape the final form of the inventory. In the final phase, two different samples (N= 875), aged 9-12 years, were used to test the validity and reliability of the inventory, using exploratory (Sample A; n = 425) and confirmatory (Sample B; n = 450) factor analyses. The results indicated that both scales possessed an acceptable internal consistency and, reliability. The factor analysis in the total of the items indicated three factors, that is "absence of state anxiety," "presence of state anxiety," and "trait anxiety." Also, confirmatory factor analysis (AMOS; Arbuckle, 1997) verified three factors. It is therefore concluded that the scales have a multifactorial structure and can be used among the Greek population to examine children’s state and trait anxiety levels.

BACKGROUND: The development of large-scale gene expression profiling technologies is rapidly changing the norms of biological investigation. But the rapid pace of change itself presents challenges. Commercial microarrays are regularly modified to incorporate new genes and improved target sequences. Although the ability to compare datasets across generations is crucial for any long-term research project, to date no means to allow such comparisons have been developed. In this study the reproducibility of gene expression levels across two generations of Affymetrix GeneChips (HuGeneFL and HG-U95A) was measured. RESULTS: Correlation coefficients were computed for gene expression values across chip generations based on different measures of similarity. Comparing the absolute calls assigned to the individual probe sets across the generations found them to be largely unchanged. CONCLUSION: We show that experimental replicates are highly reproducible, but that reproducibility across generations depends on the degree of similarity of the probe sets and the expression level of the corresponding transcript.

Purpose: The objective of this study was to compare the uptake changes of Tc-99m 2-methoxy isobutyl isonitrile (MIBI) and Tc-99m pentavalent dimercaptosuccinic acid (V-DMSA) in multiple myeloma (MM) lesions in response to high-dose chemotherapy (HDC). Materials and Methods: The authors compared Tc-99m MIBI and Tc-99m V-DMSA scans before and after HDC in a patient with focal MM lesions without amyloidosis who had received previous standard chemotherapy as well. Results: HDC had the effect of eliminating all Tc-99m MIBI uptake in the lesions. Tc-99m V-DMSA uptake was increased in lesions presenting significant initial Tc-99m MIBI uptake. In 1 particular lesion that demonstrated this phenomenon, magnetic resonance showed necrosis of the area of MM. Conclusion: The authors consider that the effect of increasing Tc-99m V-DMSA uptake in the absence of an increase in viable plasma cells possibly reflects the treatment-generated inflammatory and fibrotic changes and not necessarily viable tumor tissue. Exclusive focal Tc-99m V-DMSA uptake in this clinical setting could be considered as a sign of effectively treated lesions and not a sign of deterioration.

OBJECTIVE: To identify risk factors for fever among patients treated in a neurologic intensive care unit (NICU). METHODS: The authors prospectively studied the frequency and causes of fever, defined as a patient's first temperature > or =101 degrees F (38.3 degrees C), among 387 patients consecutively admitted to their NICU. After identifying risk factors for 1) any fever, 2) infectious fever, and 3) unexplained fever using logistic regression, they calculated disease-specific adjusted odds ratios for developing these types of fever among 12 diagnostic groups. RESULTS: Fever occurred in 23% (87/387) of patients. Fifty-two percent of fevers were explained by infection (predominantly pneumonia or bronchitis), and 28% were unexplained despite a complete diagnostic evaluation. NICU length of stay was a risk factor for all three types of fever (all p < 0.004); other risk factors included depressed level of consciousness for any fever (p = 0.005) and infectious fever (p = 0.048), endotracheal intubation for infectious fever (p = 0.01), and intraventricular catheterization for unexplained fever (p = 0.004). Subarachnoid hemorrhage increased the risk of both infectious and unexplained fever, even after adjusting for these risk factors (p = 0.006). CONCLUSION: Fever occurs in nearly 25% of NICU patients, and is associated with increased length of stay and depressed level of consciousness. Endotracheal intubation is a risk factor for infectious fever, whereas intraventricular catheterization is a risk factor for unexplained fever, which suggests a role for ventricular hemorrhage in the pathogenesis of "central" fever. Subarachnoid hemorrhage increases the risk of developing fever of all types.

Rituximab, a chimeric monoclonal antibody, produces response rates of up to 73% in patients with previously untreated indolent non-Hodgkin's lymphoma (NHL), and has high activity when combined with chemotherapy. The purpose of this phase II study was to determine the efficacy and safety of rituximab plus cyclophosphamide, mitoxantrone, vincristine and prednisone (CNOP) chemotherapy in patients with indolent NHL. In all, 42 patients (median age 67 years) with previously untreated follicular, marginal zone or small lymphocytic/lymphoplasmacytic NHL received six infusions of rituximab (375 mg/m2) in combination with six cycles of CNOP. The overall response rate was 90% comprising 30 complete (71%) and eight partial (19%) responses. Although patients with marginal zone lymphoma or International Prognostic Index (IPI) score 3 had lower complete response rates, no significant difference in overall response rate was observed between the histological groups (P = 0.24) or between patients stratified according to IPI score (P>0.05). Median overall survival, time-to-progression and response duration had not been reached after a median 19.5-month follow-up. In all, 31 patients (74%) are currently free from progression and 38 (90%) remain alive. Treatment was well tolerated. One patient (2% experienced grade 3/4 infusion-related toxicity; 13 (31%) grade 3/4 leukopenia and 18 (43%) grade 3/4 neutropenia. Infection was observed in nine patients: eight (19%) grade 1/2 and one (2.4%) grade 3. This study demonstrates that combining rituximab with CNOP achieves high remission rates without significant additional toxicity in patients with previously untreated indolent NHL. Further follow-up will determine response duration and survival.

The aim of this paper is to discuss the concept of health tourism product as a competitive tourism product with a focus on Ikaria Island, Greece. The diversification of the health tourism product is explored and the study identifies key components for a successful development of a spa resort. The paper also examines the prospects for the thermal/mineral springs of Ikaria Island, taking account of the climatic and bioclimatic regimes of the area. The study concludes that there are prospects for future development if the spa product is diversified. This, in combination with the good climatic conditions of the area, can be a starting point for providing services in order to satisfy potential clients. Β© 2003 anatolia Printed in Turkey. All rights reserved.

The present review focuses and comments on the increasing body of evidence correlating respiratory viral infections with asthma onset and exacerbations.|Recent data suggest multiple and some time contrasting roles for viral infection in the origin of asthma. These data also indicate that the immune status of the host, including atopy, may interactively contribute to this process, conferring susceptibility or even resistance to the development of asthma in virus-infected individuals. In the presence of asthma, the role of viral infection in triggering exacerbations is clearly established. Chemokine and cytokine responses of the respiratory epithelium, a biased type 1/type 2 cytokine balance, defective costimulation, as well as abnormal neural control have been suggested as possible mechanisms. The importance of concurrent or synergistic effects of allergen exposure is currently under scrutiny.|Viruses may initiate and certainly exacerbate asthma. Mild repeated infections early in life could also stimulate type 1 immune responses conferring protection from atopy and asthma. The host's immune status, the type of viral infection and the timing of exposure to various environmental stimuli are probably the key factors in this process. Mechanistic insights deduced from recent work should allow for the development of intervening strategies in the near future.

Background: After birth, apoptosis rates might slow down, compared to those in utero. Thus, factors, attenuating the apoptotic process, like the soluble forms of Fas/FasL system, may increase. Aim - study design: Soluble Fas (sFas) and soluble Fas ligand (sFasL) concentrations were measured in maternal serum (MS), umbilical cord (UC) and neonatal serum in the first (1N) and fifth (5N) days after birth in order to evaluate the alterations of these molecules during the early neonatal period. Subjects and methods: Soluble molecules were estimated in 35 healthy, appropriate for gestational age, full-term neonates, their mothers and in 25 healthy, nonpregnant women, age-matched to the mothers (controls), using enzyme immunoassays. Results: sFas concentrations in MS (p<0.01), UC (p<0.0001), 1N (p<0.0003) and 5N (p<0.02) were lower than those in controls. Neonatal sFas concentrations showed a significant increase from UC to 5N (p<0.001). In contrast, sFasL concentrations were significantly elevated in all neonatal samples (UC, 1N and 5N) compared to those in MS and controls (p<0.0001), showing also a significant elevation from UC to 5N (p<0.0001). Conclusion: Our results demonstrate increasing serum concentrations of the soluble molecules sFas and sFasL during the first days after birth, indicating possibly a gradual decrease of apoptosis in early neonatal life. © 2003 Elsevier Ireland Ltd. All rights reserved.

The paper brings together recent work in English for specific purposes/languages for specific purposes (ESP/LSP) and adult education and puts forward an integrative model for ESP curriculum design. It outlines a set of characteristics that identify the ESP learner within the general adult learning framework. Taking current theories on the adult learner profile as a starting point, it then focuses on a model that associates adult education principles with effective ESP learning. This model has two sides. One side requires the adult learner's ESP teacher to come to terms with adulthood-oriented considerations (i.e. issues unique to adult learning), such as ‘mess-management’, motivation and adult learning cycles. The other side involves both a number of ELT-methodology-specific communicative strategies that are indispensable in the ESP class, such as self-directed learning techniques, as well as enhancing the role of the ESP teacher as counsellor. Some implications for the construction of CALL programmes are discussed and the paper ends with the suggestion that all approaches to teaching learners in the ESP framework can benefit from the successful handling of both aspects of the earlier model.

We present ab initio calculations for spin injection in Fe-ZnSe and Fe-GaAs(001) systems, with and without detection by a second Fe lead. We consider the case of hot injection, as well as the presence of a tunneling barrier at the interface. Our calculations are valid in the ballistic regime. We find that these systems can be very efficient spin filters, leading to current spin polarizations and magnetoresistance ratios very close to the ideal 100%.

We calculate the current spin polarization and the interface resistance of Fe/GaAs and Fe/ZnSe (001) spin injection junctions from first principles, including also the possibility of a Schottky barrier. From our results of interface resistance we estimate the barrier thickness needed for efficient spin injection if the process is nonballistic.

Stenotrophomonas maltophilia is rarely implicated in clinical infections but it constitutes a significant nosocomial pathogen, especially in immunocompromised patients. This report describes the first case of a generalised infection caused by S. maltophilia that included bacteremia, wound and respiratory tract infection in a patient suffering from burns. Given the emergence of S. maltophilia nosocomial infections, especially in patients with burns, isolation of the bacterium from blood cultures should prompt the commencement of adequate antibiotic treatment.

Myxopapillary ependymomas (MPEs) are low-grade neuroepithelial tumors typically occurring in the conus-cauda equina-filum terminale region. Limited molecular and cytogenetic analysis of MPEs has not demonstrated consistent abnormalities. In an attempt to clarify the chromosomal status of these tumors and identify commonly aberrant regions in the genome we have combined 3 molecular/cyto/genetic methods to study 17 MPEs. Comparative genomic hybridization of 7/17 tumors identified concurrent gain on chromosomes 9 and 18 as the most frequent finding. The majority of the 17 tumors were also studied using microsatellite analysis with marker spanning the whole chromosomes 9 and 18 and interphase-FISH with centromeric probes for both chromosomes. Our combined results were consistent with concurrent gain in both chromosomes 9 and 18 in 11/17 cases, gain of either chromosome 9 or 18 and imbalance in the other chromosome in 3/17 tumors and allelic imbalances of chromosomes 9 or 18 in 3/17 and 1/17 tumors, respectively. Other abnormalities observed included gain of chromosomes 3, 4, 7, 8, 11, 13, 17q, 20, and X and loss of chromosomes 10 and 22. Our findings represent some steps towards understanding the molecular mechanisms involved in the development of MPE.

Surface deformation and ferroelectric domain switching induced by a force microscope tip on a La-modified PbTiO3 thin film was studied. Polarization switching of the domains comprising the deformed region demonstrated the possibility of using scanning force microscopy (SFM) as a nanoscale tool for imaging phase transitions. It was found that if loading forces are higher than a threshold value, thin film characterization becomes invasive.

Background: Waldenstrom's macroglobulinemia (WM) is an unusual lymphoplasmacytoid lymphoma characterized by the presence of a serum monoclonal immunoglobulin M. Although several studies have evaluated possible prognostic factors of this disease, few have focused on the survival and prognosis of symptomatic patients after the initiation of treatment. Patients and methods: Our study included 122 previously untreated patients with a median age of 67 years who required systemic treatment. Multiple variables were analyzed for their prognostic value on survival after initiation of treatment using univariate and Cox regression multivariate analysis. Results: The median overall survival was 106 months. Pretreatment factors associated with shorter survival were age ≥65 years, splenomegaly, B-symptoms (weight loss, fever or night sweats), hemoglobin <10 g/dl, platelets <100 × 106/dl, albumin <3.5 g/dl and bone marrow lymphoplasmacytic infiltrate ≥50%. In the multivariate analysis, the two variables with independent prognostic value were age ≥65 years and hemoglobin <10 g/dl. Furthermore, we were able to divide our patients into three risk groups based on the presence of two, one or none of these two adverse prognostic factors. The median survival times in the high-, intermediate- and low-risk groups were 46 months, 107 months and 172 months, respectively (P <0.0001). Discussion: Our findings suggest that advanced age and anemia appear to be the two dominant prognostic factors for survival after initiation of treatment in patients with WM. These two readily available parameters can stratify the patients into three distinct subgroups and may help the selection of appropriate treatment.

Six stars out of a sample of ~2300 carbon stars in the Magellanic Clouds have been identified as having strong C2 bands but CN bands that are very weak or absent. It is argued that five of these are likely to be R Coronae Borealis (RCB) stars on the basis of their spectral characteristics and peculiar colours. Most are variables and the Large Magellanic Cloud (LMC) members have extreme radial velocities that are more like the planetary nebula population than the carbon stars. This sample consists of four LMC members (only one of them previously recognized as an RCB star), one Small Magellanic Cloud (SMC) member (the first RCB star reported in the SMC) and one foreground Galactic star.

The synthesis of optically pure long-chain 2-amino-alcohols and 1-O-dodecyl-2-deoxy-2-amino-sn-glycerol was carried out starting from l- or d-Boc-Ser(OBn)-ol by oxidation and consecutive Wittig reaction or etherification reaction. 2-Amino-oleyl alcohol was synthesized by reduction of the corresponding 2-amino-oleic acid. All the long chain amino-alcohols presented interesting inhibition of carrageenin-induced paw edema in rats (ED50 from 0.017 to 0.010 mmol/kg). The synthesis, anti-inflammatory and analgesic activity of long-chain 2-amino-alcohols is reported.

 This review article focuses on the synthesis and reactions of N,N-di-Boc glutamate and aspartate semialdehydes as well as related aldehydes. These building blocks are prepared according to various strategies from glutamic and aspartic acids and find interesting synthetic applications. In the first part, the methods for the synthesis of N,N-di-Boc-amino aldehydes are summarized. The applications of these chiral synthons for the synthesis of unnatural amino acids and other bioactive compounds are discussed in the second section.

The systematics of the first 2+ state g factors in the mass 80 region are investigated in terms of an IBM-II analysis, a pairing-corrected geometrical model, and a shell-model approach. Subshell closure effects at N = 38 and overall trends were examined using IBM-II. A large-space shell-model calculation was successful in describing the behavior for N=4 and N=50 nuclei, where single-particle features are prominent. A schematic truncated-space calculation was applied to the lighter isotopes. The variations of the effective boson g factors are discussed in connection with the role of F-spin breaking, and comparisons are made between the mass 80 and mass 180 regions.

This paper explores the relationship of the perfect with time, in its grammatical expression both as tense and as aspect. While not denying that the perfect has other, non-temporal and non-aspectual uses, while in fact admitting that they are more wide-spread than its time-related uses, it argues that a relationship with time does exist; of the various time-related meanings associated with the perfect it is anteriority that turns out to be more “basic”, in the sense that all the other meanings of the perfect can be derived from it. The article has a strong historical bias: the basic meaning is assumed to have a historical precedence as well as a logical one. 

Recently completed phase II trials and retrospective analyses conducted outside the United States, primarily in Europe and Australia, have confirmed results of landmark US trials that established the efficacy of thalidomide in multiple myeloma. These trials evaluated thalidomide alone or in combination in patients with heavily pretreated relapsed/refractory multiple myeloma. Single-agent thalidomide induced objective responses in approximately one third of patients and prolonged survival by approximately 1 year. These trials also indicated a possible dose-response relationship of thalidomide and identified several poor prognostic factors, including advanced age, high lactose dehydrogenase level, low platelet count, and low hemoglobin level. The combination of thalidomide with dexamethasone increased overall response by approximately 20% and reduced the time to response compared with thalidomide alone. In addition, lower doses of thalidomide used in the combination may increase patient tolerability. Finally, thalidomide in combination with chemotherapy yields response rates of approximately 60%, with median survival times of approximately 18 months. Randomized trials are needed to confirm these results and further explore the role of thalidomide in these treatment settings. © 2003 Elsevier Inc. All rights reserved.

We look for the expected signature of an accretion disc by examining the properties of the Hα emission line versus viewing angle in a sample of 22 superluminal (SL) quasars. The Doppler factor δ, jet velocity γ and viewing angle θ towards the jet are derived from published radio and X-ray data. Most of the Hα spectra (14) have been observed at the United Kingdom Infrared Telescope (UKIRT) and are reported here. About a quarter of the SL objects have weak or absent Hα emission lines, with small equivalent widths (EW). These have high optical polarization, radio core dominance and Doppler factor, and most of them have high apparent SL velocity and low viewing angles. Therefore these weak-EW objects almost certainly have relativistically beamed optical continua. The strong-EW objects also show a clear beaming effect, but a much weaker one, with line EW varying by only a factor of 3 while radio core dominance varies by a factor of several hundred. The correlation of EW with θ is quantitatively in good agreement with the prediction of a flat accretion disc with limb darkening. The weak- and strong-EW sources also show an anticorrelation of line velocity width with the various beaming indicators. Again, the correlation with the derived viewing angle θ shows a quantitative agreement with the effect expected for an axisymmetric structure with velocity dominated by rotation. The line emission cannot come from the surface of the disc, or the line beaming would cancel the continuum beaming. However, it could come from an axisymmetric system of clouds corotating with the accretion disc.

The purpose of this prospective phase II trial was to investigate the safety and efficacy of a modified baseline BEACOPP (bleomycin, etoposide, adriamycin, cyclophosphamide, vincristine, procarbazine, and prednisone) regimen in the treatment of intermediate and advanced stage Hodgkin's disease (HD). From October 1997 to November 2001, 51 consecutive, previously untreated patients with stage IIA (bulky), IIB, III, and IV disease were treated with a modified baseline BEACOPP regimen with the etoposide administered i.v. on day 1 and orally at a dose of 100 mg/m2, on days 2 and 3. Each patient was scheduled to receive eight courses of BEACOPP with consolidation radiotherapy to bulky (≤5 cm) or residual disease. There were 25 males and 26 females with a median age of 32 yr (16-65 yr); 80.3% of the patients had nodular sclerosis HD, 41% had bulky disease (≥5 cm), 10 were in stage IIA (bulky ≥10 cm), 15 in stage IIB, 19 in stage III, and seven in stage IV. Thirty-seven patients (72.5%) achieved a complete response and 17.6% partial response. No significant difference in overall response rate was observed between patients with: (i) 0-2 vs. ≥3 negative prognostic factors, (ii) in stage II vs. stages III/IV, LDH level, and bulky disease. With a median follow up period of 39.5 months, actuarial 3-yr survival rate is 82% and time to progression rate 72.5%. Treatment with this combination was well tolerated. Grades 3 and 4 leukopenia and neutropenia occured in 26% and 28% of the patients, respectively, whereas in 16.3% of the patients infection was observed. Support with granulocyte colony-stimulating factor was given to 59% of the patients. No case of secondary MDS/leukemia has been observed. The results of the present study demonstrate that the modified baseline BEACOPP regimen with radiotherapy used in our patients was well tolerated and effective therapy for intermediate and advanced stage HD. Further follow up time is required to evaluate long-term toxicity.

Background: The efficacy and toxicity of gemcitabine (GEM) and irinotecan (CPT-11) is evaluated in previously untreated patients with inoperable or metastatic pancreatic cancer. Patients and methods: From January 1999 to July 2001, 60 patients with pancreatic cancer (85% stage IV) were enrolled in a two-step extended phase II trial. Patients were treated with gemcitabine (1000 mg/m2 on days 1 and 8) and CPT-11 (300 mg/m2 on day 8) in cycles of 3 weeks. No prophylactic use of recombinant human granulocyte colony-stimulating factor (rhG-CSF) was initially planned. Results: In an intention-to-treat analysis one (1.7%) complete and 14 (23.3%) partial responses were achieved [objective response rate (ORR) 24.7%; 95% confidence interval 14.04% to 35.96%]. Twenty-two (36.7%) and 23 (38.3%) patients had stable and progressive disease, respectively. The median duration of response was 5 months, the median time to tumor progression (TTP) was 7 months and the median overall survival 7 months. One-year survival was 22.5%. Pain improvement and asthenia during treatment were observed in 45% and 43% of patients, respectively; weight gain occurred in 19.5% of patients. Grade 3 anemia occurred in three (5%) patients who required transfusion of six packed red blood cell (RBC) units. Ten (16.7%) additional patients with grade 2 anemia were treated with recombinant erythropoietin. Grade 3 thrombocytopenia occurred in seven (11.7%) patients and grades 3 and 4 neutropenia in 27 (45%). Ten patients developed febrile neutropenia, two of whom died due to sepsis. Prophylactic use of rhG-CSF was eventually required in 93 (28.3%) of 329 administered cycles. Other toxicities were mild. Conclusions: The combination of gemcitabine and irinotecan is an active chemotherapy regimen against pancreatic cancer with a 25% ORR. Toxicity was acceptable for the great majority of patients but with a high percentage of hematopoietic growth factor administration.

Purpose: In 1999, investigators reported promising results of a phase II study of thalidomide in patients with resistant multiple myeloma (MM). Since then, various trials of thalidomide alone and in combination with other agents have been tested in patients with resistant and, more recently, untreated MM. In addition, preliminary results of phase I studies of the immunomodulatory derivatives (IMiDs) of thalidomide have been recently reported. Design: We reviewed and report the results of clinical trials of thalidomide and the IMiDs, as well as the pharmacology, mechanism of action, and toxicity of these agents. Results: Thalidomide has demonstrated significant activity in both resistant and previously untreated multiple myeloma. Combination therapy with dexamethasone increases response rate, even in patients previously resistant to both drugs given as single agents. More recent studies of thalidomide with dexamethasone in previously untreated patients are highly encouraging. The addition of chemotherapy to thalidomide and dexamethasone may further increase response rates, but its effect on patient survival has not been clarified. Preliminary results of trials of IMiD-3 indicate that this agent is active in resistant myeloma and has a toxicity profile different from that of thalidomide. Conclusion: Many studies have confirmed the activity of thalidomide in MM, as well as an improved response with dexamethasone. Newer thalidomide derivatives with reduced toxicity (neuropathy, teratogenicity) are also promising. Thalidomide with dexamethasone may now represent the treatment of choice for previously untreated patients. Further studies with these and other novel agents early in the course of myeloma may improve complete remission rates and frequency of long-term control. © 2003 by American Society of Clinical Oncology.

To evaluate the activity of thalidomide in Waldenstrom's macroglobulinemia (WM), 20 patients were treated on a dose schedule that escalated from 200 mg/d to 600 mg/d. On an intention-to-treat basis, five (25%) patients achieved a partial response, which was noted within 3 months of treatment. Adverse effects were common and prevented dose escalation of thalidomide in 75% of patients and led to premature discontinuation of treatment in 35%. We subsequently evaluated the oral combination of clarithromycin (500 mg twice per day), low-dose thalidomide (200 mg once daily), and dexamethasone (40 mg once per week). Our preliminary analysis on 12 previously treated patients indicate activity of this regimen in WM: three patients achieved a partial response and two patients demonstrated monoclonal protein reduction of greater than 25%. This combination was associated with a variety of side effects due not only to thalidomide, but also to corticosteroids and to clarithromycin. Our preliminary data indicate that this combination may be a useful salvage regimen for some patients with heavily pretreated macroglobulinemia. © 2003 Elsevier Inc. All rights reserved.

Fludarabine is an active agent for the treatment of Waldenstrom's macroglobulinemia (WM) and its combination with cyclophosphamide has been effective in many patients with low-grade lymphoma and chronic lymphocytic leukemia. Based on these data, we administered the combination of fludarabine (25 mg/m2 IV day 1-3) and cyclophosphamide (250 mg/m2 IV day 1 - 3,) to 11 patients with WM. Most patients had features indicating poor prognosis including median age of 73 years (range 60-84 years), hemoglobin <100g/l in 73%, B2-microglobulin >3mg/l in 64%, symptomatic hyperviscosity in 55% of patients. Only 2 patients were previously untreated, 7 were primary refractory and 2 were relapsing on treatment. The fludarabine-cyclophosphamide combination (FC) was administered every 4 weeks for a total of four courses. Partial response, defined by at least 50% reduction of serum monoclonal protein and of tumor infiltrate at all involved sites was documented in 6 patients (55%) (The median time to response was 4 months). Responding patients demonstrated resolution of disease-related symptoms and correction of anemia. Median time to progression for all patients was 24 months. With a mean follow-up of 28 months, two of six responding patients have progressed so far. The probability of 2-year survival is 70%. This regimen was relatively well tolerated. Complications included neutropenia grade 3 or 4 in 3 patients and thrombocytopenia grade 3 or 4 in 2 patients. There were five infectious episodes including two episodes of neutropenic fever. We conclude that the FC combination appears to be active in patients with WM most of whom were resistant to treatment and had poor prognostic factors. The addition of rituximab to FC requires further investigation.

O-tert-Butyldimethylsilylimidazolyl aminals are N,O-acetals that form readily from aldehydes, and although they function as aldehyde stabilizing and protecting groups under various conditions, we report here that they react with organolithium reagents similarly to the parent aldehydes. The mechanism involves the intermediate formation of a 2-imidazolyl anion as is exemplified by the isolation of 2-TBDMS-imidazole. Substitution of the imidazolyl moiety at the 2-position renders these aldehyde derivatives stable to organolithium reagents, thus allowing for the tuning of their reactivity.

O-tert-Butyldimethylsilylimidazolyl aminals are N,O-acetals that form readily from aldehydes, and although they function as aldehyde stabilizing and protecting groups under various conditions, we report here that they react with organolithium reagents similarly to the parent aldehydes. The mechanism involves the intermediate formation of a 2-imidazolyl anion as is exemplified by the isolation of 2-TBDMS-imidazole. Substitution of the imidazolyl moiety at the 2-position renders these aldehyde derivatives stable to organolithium reagents, thus allowing for the tuning of their reactivity.

Background: We investigated the efficacy and safety of 2 cycles of adjuvant chemotherapy with carboplatin, etoposide and bleomycin (CEB 90) in patients with high-risk clinical stage I or stage IM non-seminomatous germ cell tumours (NSGCT). Patients and Methods: A total of 52 consecutive patients (22 patients with high-risk histological features [vascular invasion, presence of embryonal carcinoma, absence of yolk sac tumour] and 30 with tumour marker activity post-orchidectomy-stage IM) were entered into this prospective study. Chemotherapy consisted of carboplatin 400mg/m 2 or AUC 5 (day 1), etoposide 165mg/m2 (days 1-3) and bleomycin 30 mg (days 1, 8, 15). Chemotherapy was repeated every 3 weeks. Results: During a median follow-up of 112 months (range, 10 to 174 months), two patients with stage IM relapsed. These cases had a disseminated, marker-positive germ cell tumour (GCT), extensively involving both liver and lungs in the first case and para-aortic lymph nodes and lung in the second one; both patients died of the tumour after a number of salvage chemotherapy (including high-dose therapy) regimens. Fifty patients (96%) are alive and disease-free. Two cycles of CEB90 were well tolerated and the only side-effects were myelotoxicity and alopecia. Conclusion: Despite the general consensus that ciplatin-based chemotherapy is superior to carboplatin-containing regimens in testicular cancer, 2 cycles of CEB 90 may be an equally effective treatment option as adjuvant therapy for high-risk clinical stage I and IM patients.

Living coccolithophores were collected from eight stations along a transect in the gulf of Korthi (southeastern Andros island, Aegean Sea, Eastern Mediterranean) in August 2001. Samples were collected from 0–120 m water depth to determine the cell density, the species composition and the biogeographical (spatial and vertical) distribution of the coccolithophore biocommunities in coastal marine ecosystems. The studies revealed an impressive heterococcolith–holococcolith combination coccosphere (SEM micrograph) involving the species Algirosphaera robusta and Sphaerocalyptra quadridentata. In addition, a second association was observed by light microscopy. This discovery verifies the suggestions of Kamptner (1941) and provides strong proof on the assignment of these two ‘species’ in a common life cycle, increasing significantly our knowledge of life-cycle pairings ecology.

Living coccolithophores were collected from eight stations along a transect in the gulf of Korthi (southeastern Andros island, Aegean Sea, Eastern Mediterranean) in August 2001. Samples were collected from 0–120 m water depth to determine the cell density, the species composition and the biogeographical (spatial and vertical) distribution of the coccolithophore biocommunities in coastal marine ecosystems. The studies revealed an impressive heterococcolith–holococcolith combination coccosphere (SEM micrograph) involving the species Algirosphaera robusta and Sphaerocalyptra quadridentata. In addition, a second association was observed by light microscopy. This discovery verifies the suggestions of Kamptner (1941) and provides strong proof on the assignment of these two ‘species’ in a common life cycle, increasing significantly our knowledge of life-cycle pairings ecology.

Most of the carbon stars observed with 2dF were selected from the newly completed catalogue of 7760 carbon stars by (Kontizas et al., 2001, Cat. , hereafter KDMK01). (1 data file).

The horizontal and vertical distributions of volatile organic compounds (VOCs) and ozone (O3) concentrations within the lower troposphere over the greater Athens area. Greece, under sea-breeze conditions were studied. Furthermore, an attempt was made to explain the dynamic and chemical mechanisms responsible for the formation of these distributions. Measurements were collected using a specially instrumented Falcon 20-E5 research aircraft, ground-based meteorological instrumentation, and a network of air quality monitoring stations within the context of the Scientific Training and Access to Aircraft for Atmospheric Research Throughout Europe (STAAARTE) 1997 experimental campaign. Relatively high ozone values (55-100 ppbv) were identified within the first 300-400 m above ground, and significantly reduced values were found over the depth of the atmospheric boundary layer. High values of VOC concentrations [150-350 ppbCarbon (C)] were observed near the ground as well as within the first 300 400 m above ground. At higher altitudes, of 1400-1600 m, VOC concentrations remained relatively high (100-200 ppbC). It was demonstrated that the sea-breeze circulation plays a major role in the formation of the above-mentioned concentration levels and that chemical transformations explain specific characteristics.

We report systematic first-principles calculations for ordered zinc-blende compounds of the transition metal elements V, Cr, and Mn with the sp elements N, P, As, Sb, S, Se, and Te, motivated by a recent fabrication of zinc-blende CrAs, CrSb, and MnAs. They show a ferromagnetic half-metallic behavior for a wide range of lattice constants. We discuss the origin and trends of half-metallicity, present the calculated equilibrium lattice constants, and examine the half-metallic behavior of their transition element terminated (001) surfaces.

Η έρευνα εστιάστηκε στην καταγραφή: -των αθλητικών συνηθειών των μαθητών Δημοτικού-Γυμνασίου-Λυκείου, -των απόψεών τους για την επάρκεια της απαιτούμενης αθλητικής υποδομής στην περιοχή μόνιμης διαμονής τους και στο σχολικό τους χώρο, -της κατανομής του ελεύθερου χρόνου για αθλητικές δραστηριότητες,  - των εκφρασμένων αντιλήψεών τους για το μάθημα της Φυσικής Αγωγής και για τη σχέση σχολείου - αθλητικών δραστηριοτήτων.

This study discusses and evaluates the views of Donald W. Winnicott (1896-1971), a distinguished British pediatrician and psychoanalyst, which explicitly or implicitly are related to loneliness and solitude. Α theoretical approach to the developmental origins of loneliness is as yet to be formulated in the field of developmental psychology. Notions such as the capacity to be alone, the good-enough mother, holding and mirroring, true and false self, childhood psychotic isolation, illusion and disillusionment, transitional object and transitional phenomenon, potential space, playing and creative activity, the non-communicating core self, the “journey” from absolute dependence towards independence, etc., are discussed in the light of their implications for the understanding of loneliness and solitude experiences. The exploration and interpretation of these notions show their usefulness in the construction of a developmental model of loneliness and solitude as well as their fruitfulness for further empirical research on this topic.

Ιn diesem Artikel die Besonderheiten des Zweitspracherwerbes hervorgehoben und auf die Bedeutung einer entsprechenden Ausbildung jener Lehrer hingewiesen, die Schüler unterrichten, für die das Neugriechische eine erste, eine zweite oder sogar eine dritte Sozialisationssprache darstellt.

Η εργασία συνιστά μια συμβολή στην πολιτισμική αξιολόγηση των αρχαίων Ολυμπιακών Αγώνων, καθώς είναι αδιαμφισβήτητος ο πολυσήμαντος ρόλος και η καταλυτική παρουσία των αγώνων στον δεδομένο ιστορικό χρόνο. Η πραγματοποίηση των αγώνων σε ένα ‘κέντρο’ αποτελεί κοινό χαρακτηριστικό της αξιολογίας των Ολυμπίων και των άλλων μεγάλων αγώνων της αρχαιότητας, καθώς αυτοί τελούνται σε τόπους οι οποίοι αποτελούν ισχυρά λατρευτικά κέντρα, στα οποία με ενδιάμεσο την θρησκευτική λατρεία η ομάδα έρχεται σε συνάφεια με τους κοινούς θεούς. Η συνεύρεση της ομάδας στα κέντρα αυτά διαμορφώνει το πρωτογενές υλικό αυτού που θ’ αποκαλεστεί αργότερα ως συνείδηση εθνική, καθώς οι ‘εθνικές’ τελετές συνιστούν επικοινωνίες κοινοτήτων και συνύπαρξη πληθυσμών, οι οποίες κατοχυρώνουν ταυτόχρονα και μια πολιτική διαλεκτική, που με τον περίφημο θεσμό της εκεχειρίας αναμφισβήτητα καθορίζει και τον πολιτικό χαρακτήρα των Ολυμπιακών Αγώνων. Η κοινή ειρηνική και ψυχαγωγική συνύπαρξη, χωρίς να υποτιμάται και ο οικονομικός χαρακτήρας της γιορτής, προσδιορίζουν ένα πλαίσιο πολυφωνίας ικανό να δημιουργήσει και να προβάλλει υψηλές φιλοσοφικές και ανθρωπιστικές ιδέες. Ο εναγκαλισμός των αγώνων υπό της τέχνης έρχεται να εκφράσει καλλιτεχνικές και πολιτιστικές αξίες, ολοκληρώνοντας τελικά μέσω της τέχνης την αποτύπωση του κλασικού αθλητή και συνδέοντάς την με την ηθική τελεολογία.

Social Representations of School-Age Children on Drugs Eleni Zymvrakaki, Kyriakos Athanasiou Summary The origins of this work go back to a series of epidemiological surveys conducted over the last twenty years and prove the ever-increasing use of illegal substances among the entire population of Greece (Kokkevi K.a., 1983, Marselos and Frangidis, 1985, Madianou et al., 1987, Dardavesis, 1993, Kokkevi and Stefanis, 1994, Madiano; et al., 1995, Gougouskidis, 2001, Charila and Kalantzi-Azizi, 2001, EKTEPN, 2002a, EKTEPN, 2002b). It is common knowledge that the use of illegal substances is reduced to one of the most important social problems. In Greece too, the problem is exacerbated, as there is an increase in the frequency of deaths from heroin use in the mainly young population, while at the same time observing... Οι απαρχές της εργασίας αυτής ανάγονται σε μια σειρά επιδημιολογικών ερευνών που διεξήχθησαν την τελευταία εικοσαετία και αποδεικνύουν την ολοένα αυξανόμενη χρήση παράνομων ουσιών στο σύνολο του πληθυσμού της Ελλάδας(Κοκκέβη Κ.α., 1983, Μαρσέλος και Φραγκίδης, 1985, Μαδιανού κ.α., 1987, Δαρδαβέσης, 1993, Κοκκέβη και Στεφανής, 1994, Μαδιανό; Κ.α., 1995, Γκουγκουσκίδης, 2001, Χαρίλα και Καλαντζή-Αζίζι, 2001, ΕΚΤΕΠΝ, 2002α, ΕΚΤΕΠΝ, 2002β).Είναι κοινός τόπος ότι η χρήση παράνομων ουσιών ανάγεται σε ένα σε ένα από σημαντικότερα κοινωνικά προβλήματα. Και στην Ελλάδα το πρόβλημα οξύνεται, καθώς παρατηρείται αύξηση της συχνότητας θανάτων από τη χρήση ηρωίνης στο νεανικό κυρίως πληθυσμό, ενώ ταυτόχρονα παρατηρεί τω...

http://www.dardanosnet.gr/book_details.php?id=1041Κωδικός καταλόγου: 402089 ISBN: 978-960-402-089-7 1η ανατύπωση Απρίλιος 2005 (1η έκδοση, Μάιος 2003) 14 x 21 σελ. 451 Κωνσταντίνα Γογγάκη Αντιλήψεις των αρχαίων Ελλήνων για τον Αθλητισμό (Οι) Εκδόσεις: Τυπωθήτω Περίληψη.  Ο αθλητισμός, αποτελώντας ένα τμήμα της κοινωνικής ζωής, επηρεάζει την κοινωνία και επηρεάζεται απ' αυτήν. Έτσι, ο κλασικός αθλητισμός, συνιστώντας μιαν έκφανση της εποχής της ακμής, αντανακλά μιαν από τις πιο δυναμικές πτυχές αυτής της περιόδου. Η σημασία του αθλητισμού, ο πολυσήμαντος ρόλος του, η αγωνιστική νίκη που αποτύπωνει το κλέος και το κύδος των ανδρών, η συγκίνηση του αθλητικού θεάματος, συνδέονται με μερικές από τις καλύτερες στιγμές του δημιουργικού ανθρώπινου πνεύματος. Εκτός, όμως, από την θετική υπάρχει και η αρνητική όψη του αρχαίου αθλητισμού, η οποία επικρίθηκε και καυτηριάστηκε, χωρίς, ωστόσο, να επηρεάσει την εκ μέρους της αρχαίας κοινωνίας αποδοχή του αθλητικού γεγονότος, και η οποία αρνητική όψη επιβεβαιώνει τελικά, εκ του αντιθέτου, τη διαχρονική αξία του μέτρου και της ψυχικής και σωματικής εναρμόνισης. Αυτήν την διττή προσέγγιση, των φωτεινών και των σκοτεινών πλευρών του αρχαίου αθλητισμού, επιχειρεί η παρούσα εργασία, λαμβάνοντας υπ' όψιν τις πηγές της κλασικής παράδοσης. Με τον τρόπο αυτό ξετυλίγεται ένα πλούσιο υλικό, που αποκαλύπτει τις αντιλήψεις των αρχαίων Ελλήνων για τον αθλητισμό, από τον Όμηρο, τον Τυρταίο, τον Πίνδαρο και τον Πλάτωνα, έως τον Γαληνό, τον Φιλόστρατο, τον Παυσανία και τον Λιβάνιο, ενώ, παράλληλα, γίνεται αναφορά σε ορισμένους Ρωμαίους συγγραφείς. Από τη γενική αξιολόγηση του αρχαίου αθλητισμού και τις αντιστοιχίες του στο σύγχρονο αθλητικό γίγνεσθαι, εντέλει αποδεικνύεται πως ο λόγος περί ηθικής και μέτρου στον αθλητισμό είναι όχι μόνον διαχρονικός, αλλά, σήμερα, άκρως αναγκαίος και επίκαιρος. Περιεχόμενα.  Πρόλογος Ανδρέα Μάνου || Εισαγωγή || Οι αθλητικοί αγώνες στην Ιλιάδα και την Οδύσσεια: Μια συγκριτική θεώρηση || Η αγωνιστική νίκη ως αξία στις πινδαρικές ωδές || Η σημασία της νίκης μέσα από τον τύπο του ηττημένου αθλητή κατά τον Πίνδαρο || Προσέγγιση των Πυθίων αγώνων δια της αγγελικής ρήσης στην "Ηλέκτρα" του Σοφοκλή || Η κατά Πλάτωνα "Περί Γυμναστικής" διδασκαλία || Το στεφάνι του νικητή των αγώνων και οι ηθικοί συμβολισμοί του || Το νόημα της ολυμπιακής νίκης στην κλασική αρχαιότητα || Η πολιτισμική αξία των αρχαίων ολυμπιακών αγώνων || Μορφές βίας στα αρχαία αθλήματα || Επικριτικοί λόγοι κατά του αρχαίου αθλητισμού || Γενική βιβλιογραφία || Ευρετήριο ονομάτων || Ευρετήριο εννοιών.

The aim of this study was to investigate school-age children's perceptions and experience of family-related loneliness, and of coping with it. The literature review showed that these dimensions have not been empirically investigated. This study is part of a larger research program that examined children's perceptions of loneliness and its causes, as well as coping with loneliness strategies. Individual interviews were conducted (the interview was constructed on the basis of two pilot studies) and the projective technique of oral story was used with 180 second, fourth and sixth graders. Also, 758 fifth and sixth graders were asked to write a story about loneliness. The samples were randomly chosen from schools in Athens and Piraeus. Children's responses indicating their personal, subjective views of family-related loneliness are discussed within mainly the psychoanalytic developmental framework, and their importance for the construction of a developmental model of loneliness experience in childhood is noted.

Το στεφάνι του νικητή των αγώνων υποδηλώνει την ύπαρξη παλαιών δοξασιών, που κατά την μακρινή πορεία του χρόνου έλαβαν άλλες μορφές ή απωθήθηκαν στο υποσυνείδητο της ανθρωπότητας. Η καταγωγή τους ανάγεται στο βαθύ παρελθόν, τότε που ο πρωτόγονος άνθρωπος ανέπτυσσε τις διάφορες λατρείες στην βάση οτι όλα τ’ άψυχα έχουν ψυχή, κι επομένως το δέντρο και συνεπώς το κλαδί έχουν και μπορούν να μεταδώσουν την θετική δύναμή τους. Οι διάφορες μαγικές και ανιμιστικές θεωρίες γρήγορα ενσωματώνονται στις αγροτικές τελετές που ως σκοπό είχαν την γονιμότητα και την ευφορία της γης. Με την επίδραση του ορθολογικού στοιχείου πάνω στο μαγικό και στο μεταφυσικό, οι δοξασίες αυτές μεταβάλλονται, προσδίδοντας στο στεφάνι και τα κλαδιά ορισμένων δέντρων, όπως η ελιά και η δάφνη, έναν χαρακτήρα ιερό. Έτσι στις ήδη υπάρχουσες δοξασίες κυριαρχούν οι θρησκευτικές αντιλήψεις, του εξαγνισμού και της κάθαρσης, ηθικές αξίες που μεταδίδονται μέσω του ιερού στεφανιού στον νικητή των αγώνων, ο οποίος με τον τρόπο αυτό καθαίρεται, αποκτώντας την ικανότητα επικοινωνίας με το θείον. Κατάλοιπα αυτών των αντιλήψεων επιβιώνουν σήμερα όχι μόνο στο στεφάνι του νικητή των αγώνων, αλλά και σ’ άλλα έθιμα, όπως στο στεφάνι του Μαγιού, στο στεφάνι του γάμου κ.λ.π.  

как письмо в редакцию,  Москва, 2003. (Αναδημοσίευση στην ΠΕΜΠΤΟΥΣΙΑ στις 23/7/2013 στα Ρωσικά) Η δημοσίευση περιλαμβάνει τις κυριότερες θέσεις της διδακτορικής διατριβής για την ηθική θεώρηση της υποβοηθούμενης αναπαραγωγής στο ιατρικό περιοδικό «Ιατρική Βοήθεια» στη ρωσική γλώσσα με τη μορφή γράμματος προς τον εκδότη του περιοδικού (Letter to Editor), στην οποία συνέδραμε ο Ρώσος νευροχειρούργος Boleslav Lichtermann. Η σύνταξη του Ρωσικού περιοδικού ζήτησε τη δημοσίευση των συμπερασμάτων της διατριβής μας για να προβληθούν τα ηθικά διλήμματα που προκύπτουν στις αναπαραγωγικές τεχνολογίες. 

Relative kinetic data were determined for the 5-endo-trig cyclization of radical 12 compared to hydrogen abstraction from (TMS) 3SiH in the temperature range of 344-430 K, which allows for the estimation of a rate constant of 2 × 10 4 s -1 at 298 K with an activation energy of ca. 9 kcal/mol for the cyclization process. The 5-endo-trig cyclization of a variety of radicals that afford five-membered nitrogen-containing heterocycles was addressed computationally at the UB3LYP/6-31G* level. The 5-endo vs 4-exo mode of cyclication and the effect of delocalization of the unpaired electron in the transition state were investigated. Because the ring formed during cyclization contains five sp 2 centers, electrocyclization via a pentadienyl-like resonance form was also considered. For comparison, similar calculations were performed for 4-penten-1-yl and related radicals. The factors that affect the activation energies of homolytic 5-endo-trig cyclization were determined. In the absence of steric or conformational effects, the endo cyclization to form the five-membered ring was strongly favored over exo cyclization to form the four-membered ring not only on thermodynamic grounds but also kinetically. When a substituent on the double bond was able to delocalize the unpaired electron in the transition state of the 4-exo path, the two modes of cyclization became kinetically comparable. These results have an important bearing on the generalization of the Baldwin-Beckwith rules, which classified the 5-endo-trig radical cyclization as a "disfavored" process.

Relative kinetic data were determined for the 5-endo-trig cyclization of radical 12 compared to hydrogen abstraction from (TMS)(3)SiH in the temperature range of 344-430 K, which allows for the estimation of a rate constant of 2 x 10(4) s(-1) at 298 K with an activation energy of ca. 9 kcal/mol for the cyclization process. The 5-endo-trig cyclization of a variety of radicals that afford five-membered nitrogen-containing heterocycles was addressed computationally at the UB3LYP/6-31G* level. The 5-endo vs 4-exo mode of cyclication and the effect of delocalization of the unpaired electron in the transition state were investigated. Because the ring formed during cyclization contains five sp(2) centers, electrocyclization via a pentadienyl-like resonance form was also considered. For comparison, similar calculations were performed for 4-penten-1-yl and related radicals. The factors that affect the activation energies of homolytic 5-endo-trig cyclization were determined. In the absence of steric or conformational effects, the endo cyclization to form the five-membered ring was strongly favored over exo cyclization to form the four-membered ring not only on thermodynamic grounds but also kinetically. When a substituent on the double bond was able to delocalize the unpaired electron in the transition state of the 4-exo path, the two modes of cyclization became kinetically comparable. These results have an important bearing on the generalization of the Baldwin-Beckwith rules, which classified the 5-endo-trig radical cyclization as a "disfavored" process.

CD40 ligand (CD40L, CD154) is overexpressed on T and B cells in systemic lupus erythematosus (SLE). Monocytes have been shown to contribute to immune-mediated pathology in SLE and to express CD40L under certain conditions. Therefore, we studied CD40L expression on lupus monocytes ex vivo, as well as after activation in vitro. A highly significant sevenfold increase in the frequency of CD40L-expressing peripheral monocytes from 23 SLE patients, compared to 16 healthy individuals (mean percentage of CD40L+CD14+ among CD14+ cells, 11.7 versus 1.6), was found by flow cytometry. Increased CD40L expression on monocytes correlated significantly with disease activity, elevated γ-globulin serum levels, as well as increased CD40L expression on T cells. CD40L expression by lupus monocytes was verified at both the mRNA and protein levels, while LPS stimulation was found to upregulate CD40L mRNA accumulation and surface protein expression. CD40L expression on activated lupus monocytes within anti-CD3-stimulated, mononuclear cell cultures was also enhanced compared to control-derived monocytes. These novel findings underscore the multiplicity of pathways through which monocytes may contribute to SLE pathology and suggest that T cell-independent CD40L-mediated cell to cell interactions may be also involved in humoral immune activation in SLE. © 2002 Elsevier Science (USA).

We examined the plasma concentration curve obtained over 6 h after the ingestion of 2 g of creatine (Cr) (equivalent to 2.3 g Cr·H2O) contained in meat or in solution in five non-users of creatine supplements. Peak plasma creatine concentration was lower after the ingestion of meat but was maintained close to this for a longer period. Measurements of the area under the plasma concentration curve indicated approximate bioequivalence of creatine contained in meat with the same dose supplied in a solution. In a separate study, we examined the plasma concentration-time curve after ingestion of solid Cr·H2O. Creatine ingested as a lozenge (crushed in the mouth and swallowed) or as a crystalline suspension in ice cold water resulted in a 20% lower peak concentration and 30-35% smaller area under the plasma creatine concentration curve than the same dose administered in solution. Despite a possibly lower bioavailability, 2.3 g Cr·H2O supplied in either solid form was nonetheless sufficient to raise the plasma concentration five- to six-fold in individuals with a mean body mass of 75.6 kg. We conclude that creatine administered as meat or in solid form is readily absorbed but may result in sligthly lower peak concentrations than when the same dose is ingested as a solution.

We examined the plasma concentration curve obtained over 6 h after the ingestion of 2 g of creatine (Cr) (equivalent to 2.3 g Cr·H2O) contained in meat or in solution in five non-users of creatine supplements. Peak plasma creatine concentration was lower after the ingestion of meat but was maintained close to this for a longer period. Measurements of the area under the plasma concentration curve indicated approximate bioequivalence of creatine contained in meat with the same dose supplied in a solution. In a separate study, we examined the plasma concentration-time curve after ingestion of solid Cr·H2O. Creatine ingested as a lozenge (crushed in the mouth and swallowed) or as a crystalline suspension in ice cold water resulted in a 20% lower peak concentration and 30-35% smaller area under the plasma creatine concentration curve than the same dose administered in solution. Despite a possibly lower bioavailability, 2.3 g Cr·H2O supplied in either solid form was nonetheless sufficient to raise the plasma concentration five- to six-fold in individuals with a mean body mass of 75.6 kg. We conclude that creatine administered as meat or in solid form is readily absorbed but may result in sligthly lower peak concentrations than when the same dose is ingested as a solution.

We examined the plasma concentration curve obtained over 6 h after the ingestion of 2 g of creatine (Cr) (equivalent to 2.3 g Cr·H2O) contained in meat or in solution in five non-users of creatine supplements. Peak plasma creatine concentration was lower after the ingestion of meat but was maintained close to this for a longer period. Measurements of the area under the plasma concentration curve indicated approximate bioequivalence of creatine contained in meat with the same dose supplied in a solution. In a separate study, we examined the plasma concentration-time curve after ingestion of solid Cr·H2O. Creatine ingested as a lozenge (crushed in the mouth and swallowed) or as a crystalline suspension in ice cold water resulted in a 20% lower peak concentration and 30-35% smaller area under the plasma creatine concentration curve than the same dose administered in solution. Despite a possibly lower bioavailability, 2.3 g Cr·H2O supplied in either solid form was nonetheless sufficient to raise the plasma concentration five- to six-fold in individuals with a mean body mass of 75.6 kg. We conclude that creatine administered as meat or in solid form is readily absorbed but may result in sligthly lower peak concentrations than when the same dose is ingested as a solution.

Le pretese continuarono con il successivo Premier turco Yilmaz, che estese la linea di provocazione mettendo in discussione ora lo stesso Trattato di pace di Losanna del 1923, trattato che costituisce il punto di riferimento giuridico obbligato dello status delle frontiere nel Mediterraneo orientale e dintorni. Circa ottanta anni dopo la firma e l’entrata in vigore di quel trattato di pace, il signor Yilmaz asserisce che ci sono “aree grigie” riguardo alla sovranità greca sugli isolotti e scogli dell’Egeo, che egli tuttavia rifiuta persistentemente di definire. Il governo turco ha costantemente respinto le richieste della Comunità internazionale di abbandonare le sue infondate pretese o di portarle davanti alla Corte Internazionale di Giustizia per una risoluzione pacifica. Ora la Turchia, contravvenendo a tutte le norme della legge e della logica, solleva pretese riguardo all’isola greca di Gaudos, il cui status giuridico era già stabilito fin dal 1913, dieci anni prima cioè del trattato di Losanna. In base all’articolo 4 del trattato di pace di Londra del 1913 la Turchia aveva già rinunciato a tutti i diritti di sovranità su Creta e Gaudos. In seguito il trattato di pace di Losanna del 1923 stabilì in modo più specifico le frontiere turche nell’area del Mediterraneo orientale, dal Mar Nero fino alla Persia. Dal momento che vi è compreso il Mare Egeo, il trattato di Losanna stabilisce specificamente che la sovranità turca è mantenuta solo su quelle isole che si trovano entro 3 miglia dalla costa turca, nonché sulle isole di Imbro, Tenedo e Rabbit. Questo regime giuridico nel Mediterraneo orientale è stato rispettato per quasi ottanta anni. Gli improvvisi tentativi turchi rivolti a rigettare, in maniera unilaterale, la validità di tale regime costituiscono una reale e incombente minaccia per la pace e la stabilità dell’intera regione.

The goal of this study is to estimate the relation between air temperature and precipitation in Greece and, thereafter, to define the regions of the covariability of the two parameters. For that purpose, the air temperature and precipitation mean monthly data of 30 meteorological stations, for the period 1950-2000, are analyzed. The first step is the application of Factor Analysis (FA) to each of the two variable groups of the seasonal air temperature and precipitation. The aim is to reduce the number of variables in each group and, more specific, to define the main significant factors for each parameter. The second step is the application of Canonical Correlation Analysis (CCA) to the factor scores of each parameter, derived by the use of PCA, so that the canonical pairs are extracted and the number of the pairs are equal to the minimum number of variables in either set. In the process, the computed canonical scores are correlated to the respective original data, aiming to define regions of positive and negative correlations between the canonical roots of the air temperature and precipitation.

The effect of the synoptic-scale atmospheric circulation on the urban heat island phenomenon over Athens, Greece, was investigated and quantified for a period of 2 yr. employing a neural network approach. A neural network model was appropriately designed and tested for the estimation of the heat island intensity at 23 stations during the examined period. The day-by-day synoptic-scale atmospheric circulation in the lower troposphere for the same period was classified into eight statistically distinct categories. The neural network model employed as an input the corresponding synoptic categories in conjunction with four meteorological parameters that are closely related to the urban heat island. It was found that the synoptic-scale circulation is a predominant input parameter, affecting considerably the heat island intensity. Also, it was demonstrated that the high pressure ridge mostly favors the heat island phenomenon and categories characterized by intense northerly component winds are responsible for its nonappearance or termination.

Benthic foraminifera widespread occurrence, numerical abundance and high fossilization potential rank them among the most powerful biological tools to reconstruct paleoenvironments. Their diversity and composition by suborder sometimes provide a general indication of the past environment, but the benthic taxonomic composition and recognition of faunal assemblages allow more detailed assessments of water depth, intertidal level, salinity, exposure to water turbulence, bottom oxygen concentrations, water temperature and carbon flux. The distribution of benthic foraminifera group is determined, and an analysis of the data is made in an effort to isolate and identify  important relationships between the distribution of organisms studied and the parameters of the physical environment. Benthic Foraminifera of the Upper Pliocene Tsoutsouras section (southern Crete) are analysed in order to investigate their relationship with paleodepth, sediment grain size and climatic changes. This paper encompasses the first detailed quantitative paleoenvironmental analysis based on benthic foraminifera from this area. Q-mode analysis revealed the existence of three associations. A. beccarii-Miliolids association corresponds to a rather shallow marine environment with vegetation in the neighbourhood. A. planorbis-Agglutinants is characterized by a decline in the salinity and the existence of moderate environmental stress which is associated by oxygen depletion and increase of primary productivity. In the upper part of the section V.bradyana – C. carinata association represents theestablishment of a restricted environment with abundant nutrient, where organic matter accumulates and infaunal opportunistic species capable of surviving in stressed conditions dominate.

Benthic foraminifera widespread occurrence, numerical abundance and high fossilization potential rank them among the most powerful biological tools to reconstruct paleoenvironments. Their diversity and composition by suborder sometimes provide a general indication of the past environment, but the benthic taxonomic composition and recognition of faunal assemblages allow more detailed assessments of water depth, intertidal level, salinity, exposure to water turbulence, bottom oxygen concentrations, water temperature and carbon flux. The distribution of benthic foraminifera group is determined, and an analysis of the data is made in an effort to isolate and identify  important relationships between the distribution of organisms studied and the parameters of the physical environment. Benthic Foraminifera of the Upper Pliocene Tsoutsouras section (southern Crete) are analysed in order to investigate their relationship with paleodepth, sediment grain size and climatic changes. This paper encompasses the first detailed quantitative paleoenvironmental analysis based on benthic foraminifera from this area. Q-mode analysis revealed the existence of three associations. A. beccarii-Miliolids association corresponds to a rather shallow marine environment with vegetation in the neighbourhood. A. planorbis-Agglutinants is characterized by a decline in the salinity and the existence of moderate environmental stress which is associated by oxygen depletion and increase of primary productivity. In the upper part of the section V.bradyana – C. carinata association represents theestablishment of a restricted environment with abundant nutrient, where organic matter accumulates and infaunal opportunistic species capable of surviving in stressed conditions dominate.

Benthic foraminifera widespread occurrence, numerical abundance and high fossilization potential rank them among the most powerful biological tools to reconstruct paleoenvironments. Their diversity and composition by suborder sometimes provide a general indication of the past environment, but the benthic taxonomic composition and recognition of faunal assemblages allow more detailed assessments of water depth, intertidal level, salinity, exposure to water turbulence, bottom oxygen concentrations, water temperature and carbon flux. The distribution of benthic foraminifera group is determined, and an analysis of the data is made in an effort to isolate and identify  important relationships between the distribution of organisms studied and the parameters of the physical environment. Benthic Foraminifera of the Upper Pliocene Tsoutsouras section (southern Crete) are analysed in order to investigate their relationship with paleodepth, sediment grain size and climatic changes. This paper encompasses the first detailed quantitative paleoenvironmental analysis based on benthic foraminifera from this area. Q-mode analysis revealed the existence of three associations. A. beccarii-Miliolids association corresponds to a rather shallow marine environment with vegetation in the neighbourhood. A. planorbis-Agglutinants is characterized by a decline in the salinity and the existence of moderate environmental stress which is associated by oxygen depletion and increase of primary productivity. In the upper part of the section V.bradyana – C. carinata association represents theestablishment of a restricted environment with abundant nutrient, where organic matter accumulates and infaunal opportunistic species capable of surviving in stressed conditions dominate.

Benthic foraminifera widespread occurrence, numerical abundance and high fossilization potential rank them among the most powerful biological tools to reconstruct paleoenvironments. Their diversity and composition by suborder sometimes provide a general indication of the past environment, but the benthic taxonomic composition and recognition of faunal assemblages allow more detailed assessments of water depth, intertidal level, salinity, exposure to water turbulence, bottom oxygen concentrations, water temperature and carbon flux. The distribution of benthic foraminifera group is determined, and an analysis of the data is made in an effort to isolate and identify  important relationships between the distribution of organisms studied and the parameters of the physical environment. Benthic Foraminifera of the Upper Pliocene Tsoutsouras section (southern Crete) are analysed in order to investigate their relationship with paleodepth, sediment grain size and climatic changes. This paper encompasses the first detailed quantitative paleoenvironmental analysis based on benthic foraminifera from this area. Q-mode analysis revealed the existence of three associations. A. beccarii-Miliolids association corresponds to a rather shallow marine environment with vegetation in the neighbourhood. A. planorbis-Agglutinants is characterized by a decline in the salinity and the existence of moderate environmental stress which is associated by oxygen depletion and increase of primary productivity. In the upper part of the section V.bradyana – C. carinata association represents theestablishment of a restricted environment with abundant nutrient, where organic matter accumulates and infaunal opportunistic species capable of surviving in stressed conditions dominate.

BACKGROUND: Psychiatric symptoms occur frequently in the course of AD, are a frequent contributor to institutionalization, predict cognitive decline and death, and often require treatment with psychotropic medications. Previous studies investigating the association between APOE genotype and psychiatric symptomatology in AD have reported contradictory results. OBJECTIVE: To determine whether APOE genotype predicts incident psychiatric symptomatology in patients with AD. METHODS: Eighty-seven patients with AD at early stages and no psychiatric history were followed semiannually for up to 9.3 years (mean 5.5 years) for development of delusions, illusions, hallucinations, behavioral symptoms, and depression. Cox proportional hazards models were used to examine the relative risk for incident psychiatric symptomatology (outcome) in relation to APOE genotype (predictor). RESULTS: The presence of one epsilon4 allele carried a 2.5-fold risk, whereas the presence of two epsilon4 alleles carried a 5.6-fold risk for development of delusions. The associations remained significant even when age, ethnicity, sex, education, duration of disease, and cognitive and functional performance were controlled for. The presence of two epsilon4 alleles was associated with reduced risk for developing hallucinations in the adjusted analysis only. No significant associations were detected between APOE genotype and the incidence of illusions, behavioral symptoms, or depression. CONCLUSION: The presence of one or more epsilon4 alleles is a significant predictor for the incidence of delusions in the course of AD.

In this paper we propose a new algorithm for the detection of clustered microcalcifications using mathematical morphology and artificial neural networks. Considering each mammogram as a topographic representation, each microcalcification appears as elevation constituting a regional maxima. Morphological filters are applied, in order to remove noise and regional maxima that doesn't correspond to calcifications. Each suspicious object is marked using a binary image and finally a feed forward neural network classifies every object achieving a rate of 90% true positive detections with 0.11 false positives per image.

We present ab initio calculations of the spin-dependent electronic transport in Fe/GaAs/Fe and Fe/ZnSe/Fe (001) junctions simulating the situation of a spin-injection experiment. We follow a ballistic Landauer-Buttiker approach for the calculation of the spin-dependent dc conductance in the linear-response regime, in the limit of zero temperature. We show that the bulk band structure of the leads and of the semiconductor, and even more the electronic structure of a clean and abrupt interface, are responsible for a current polarization and a magnetoresistance ratio of almost the ideal 100%, if the transport is ballistic. In particular, we study the significance of the transmission resonances caused by the presence of two interfaces.

We consider the spin injection from Fe into ZnSe and GaAs in the ballistic limit. By means of the ab initio screened Korringa-Kohn-Rostoker method we calculate the ground-state properties of epitaxial Fe\textbackslash{}ZnSe(001) and Fe\textbackslash{}GaAs(001) heterostructures. Three injection processes are considered: injection of hot electrons and injection of ``thermal{''} electrons with and without an interface barrier. The calculation of the conductance by the Landauer formula shows that these interfaces act like a nearly ideal spin filter, with spin polarization as high as 99%. This can be traced back to the symmetry of the band structure of Fe for normal incidence.

Determinations of the cadmium content of a wide variety of foodstuffs from the Greek market were carried out. The values detected ranged from <0.1 ng g-1 in alcoholic beverages to 1595.8 ng g-1 in large snails. The highest values were observed in molluscs and crustaceans (117.4ng g-1), followed by leafy vegetables (28.3 ng g-1), potatoes (22.3 ng g-1) and organs and offal (20.7 ng g-1), whereas the other food categories had a lower cadmium content. The results are comparable with those from the rest of Europe. Preliminary analytical data on the cadmium content of food samples of organic cultivation showed significantly lower values compared with those of samples of conventional produce.

This chapter describes all the recent advances in statistical and syntactic pattern recognition, along with a number of the most important hybrid efforts in pattern recognition methodology, which together with structural pattern recognition, are the future trends in pattern recognition applications' schemes.

Objectives. Ifosfamide, paclitaxel, and cisplatin have moderate single-agent activity in patients with metastatic or recurrent cancer of the uterine cervix. We administered a combination of these three agents to a large number of patients with metastatic or recurrent cervical cancer to evaluate its activity. Methods. Sixty patients were treated on an outpatient basis with Ifosfamide (I) 1500 mg/m2 intravenously over 1 h on Days 1-3, paclitaxel (T) 175 mg/m2 as a 3-h intravenous infusion on Day 1, and cisplatin (P) 75 mg/m2 intravenously over 2 h on Day 2 with granulocyte colony-stimulating factor (G-CSF) support. The chemotherapy was repeated every 4 weeks for a maximum of six courses. Results. Fifty-seven patients received at least two courses of treatment and are evaluable for response. Twenty-six patients (46%) achieved an objective response, including 19% complete and 27% partial responses. The median duration of response was 11.5 months and the median time to progression and survival for all patients were 8.3 and 18.6 months, respectively. Patients with excellent performance status, with disease recurrence outside the radiation field, and with nonsquamous tumors had the highest response rate and best survival. Some degree of neurotoxicity occurred in 44% of patients. Grade 3 or 4 toxicity included granulocytopenia in 26% of patients, anemia in 13%, thrombocytopenia in 7%, and neurotoxicity in 3%. Conclusion. The ITP regimen is relatively well tolerated and moderately active in patients with metastatic carcinoma of the uterine cervix. Patients more likely to benefit are those with nonsquamous histology, with excellent performance status, and with disease recurrence outside the radiation field. © 2002 Elsevier Science (USA).

In this paper we are going to develop group replacement policies for a service system by considering the number of customers dynamically in the queue. We consider a service system with multiple independent servers operating in parallel and a single queue. Customers arrive in accordance with a Poisson process, and the service time for each customer follows an exponential distribution. The servers are unreliable with identically exponentially distributed failure times and the repair time is assumed negligible. We formulate this model as a continuous time Markov decision process, and prove the optimal group replacement policy has a threshold structure.

Kamberidou, Irene  (2002). Dance and Physical Activity as a Symbol of Social Inferiority in the Ottoman Empire.  Proceedings of the 7th Annual Congress of the European College of Sport Science. Editors Maria Koskolou, Nickos Geladas, Vassilis Klissouras, Volume 2, Athens, 24-28 July, 2002 (S659/p. 577).[1] [1] Συμμετείχα στο συνέδριο, που οργανώθηκε από την Ελληνική Εταιρεία Αθλητικής Επιστήμης (ΕλΕΑΘλΕ) στην Αθήνα: ως (1) Μoderator στην έναρξη του συνεδρίου, (2) προεδρεύων στο session “Ethics in Sport” και (3) με δύο ανακοινώσεις, σε δύο sessions.

Rhinoviruses (RVs) are the most frequent precipitants of the common cold and asthma exacerbations, but little is known about the immune response to these viruses and its potential implications in the pathogenesis of asthma.|Peripheral blood mononuclear cells (PBMC) from patients with atopic asthma and normal subjects were exposed to live or inactivated RV preparations. Levels of interferon (IFN)gamma and interleukins IL-12, IL-10, IL-4, IL-5 and IL-13 were evaluated in the culture supernatants with specific immunoassays.|Exposure of PBMC to RVs induced the production of IFNgamma, IL-12, IL-10, and IL-13. Cells from asthmatic subjects produced significantly lower levels of IFNgamma and IL-12 and higher levels of IL-10 than normal subjects. IL-4 was induced only in the asthmatic group, while the IFNgamma/IL-4 ratio was more than three times lower in the asthmatic group.|This evidence suggests that the immune response to RVs is not uniquely of a type 1 phenotype, as previously suggested. The type 1 response is defective in atopic asthmatic individuals, with a shift towards a type 2 phenotype in a way similar, but not identical, to their aberrant response to allergens. A defective type 1 immune response to RVs may be implicated in the pathogenesis of virus induced exacerbations of asthma.

We measure single electron movement between two coupled quantum dots each isolated from a reservoir. The electrons movement is detected using a 1-D channel placed next to the double dot system. The electrostatic energy required to move an electron from one dot to a reservoir is half that required to move the electron from one dot to the other dot. We estimate the maximum intra-dot scattering time at < 0.2 ns. This scattering time corresponds to a lifetime broadening equal to the thermal broadening (80 mK) indicating that the scattering time may be longer than this. © 2002 Elsevier Science B.V. All rights reserved.

HBV DNA quantitation is used extensively for the monitoring of treatment of hepatitis B virus (HBV) infection. The aim of this study was to develop a highly sensitive and reproducible real-time PCR (RTD-PCR) assay for the quantitation of HBV DNA using the LightCycler system. The performance of this assay was assessed by analyzing serial dilutions of HBV genomic DNA of known concentration and the lower limit of detection was found to be 1 DNA copy/reaction. By using serial dilutions of plasmid standard, RTD-PCR was determined to quantify HBV DNA in a 10-log10 dynamic range. RTD-PCR was found to be more sensitive than the commercially available tests such as the Quantiplex HBV DNA and the AMPLICOR HBV MONITOR assays. The median coefficient of variation of interexperimental variability was 3.2%. The HBV DNA values obtained with RTD-PCR were highly correlated with assays available commercially. These findings suggest that our RTD-PCR assay combines high sensitivity and reproducibility for HBV DNA quantitation in an incomparable high dynamic range of quantitation.

Scanning force microscopy in the dynamic contact mode with resonance enhanced domain contrast is applied to study in situ pattern formation and relaxation kinetics of ferroelectric domains on the cleavage surface of triglycine sulfate subjected to successive annealing-cooling cycles. Substantial differences in the domain morphology and kinetics are disclosed upon cooling at temperatures close to Tc. Convolution of stripe domains with residual domain nuclei and random pinning forces due to intrinsic defects are suggested to account for variations in the domain structure and slowing down of domain kinetics.

Purpose. (i) Evaluate the predictive performance of the fractal volume of drug distribution, v(f), (Pharm. Res.18, 1056, 2001), (ii) develop the concept of the fractal clearance, CLf, which is the clearance analogue of v(f), (iii) examine the utility of CLf in allometric studies, (iv) develop allometric relationships for the elimination half-life, t(1/2), and (v) evaluate the use of v(f) and CLf in predicting the volume of drug distribution, V-ap, clearance, CL, and elimination half-life, t(1/2). Methods. Estimates for v(f) of various drugs were obtained and correlated with body mass using data only from animal species. A comparison was made between the predicted and actual v(f) values for humans. For a variety of animal species CLf values were estimated from the equation: CLf = v(f)/V-ap CL The allometric equations developed using CLf were compared with other allometric approaches. Allometric equations were also developed for t(1)/2 utilizing the allometric relationships of v(f) and CLf. Results. The predicted estimates of v(f) were very close to the actual values and the correlation exhibited favorable statistical properties. The values of the allometric exponents for CLf were found to be close to 0.75. The predictive performance for CL using the allometric equations for CLf in conjuction with the rule of exponents was found to be better than the currently considered most accurate allometric approaches. The values of the allometric exponents for t(1)/2 were found to be close to 0.25. Conclusion. The predictive ability of v(f) is high; predictions for V(a)p based on v(f) values are better than the current approaches. CLf expressed a good behavior both in prospective and retrospective analysis. The allometric exponents, 0.75, 0.25 for CLf and t(1/2), respectively, agree with the theoretical expected values.

We consider the problem of dynamic admission control in a Markovian loss queueing system with two classes of jobs with different service rates and random revenues. We establish the existence of an optimal monotone policy. We also show that under certain conditions there exist preferred jobs from either class.

This chapter focused on some of the key issues of Health and Nursing Informatics Education. First an historical overview of Health and Nursing Informatics Education is presented. We also describe briefly the activities in the domain of Nursing Informatics Education across Europe. The Special Projects for Health and Nursing Informatics in Europe are presented. Because of the variety of educational systems, the International Medical Informatics Association (IMIA) felt the need to develop international recommendations in health and medical informatics education. From a nursing informatics perspective, the IMIA recommendations in Nursing Informatics Education are discussed.

The magnetic properties of the rare earth molecular compounds with hydrazone ligands containing Nd3+ Gd3+ and Yb3+ have been investigated by electron paramagnetic resonance (EPR) and magnetization measurements. For the Gd-compound, partially resolved fine structure due to Gd and exchange narrowing effects at low temperatures are observed in the EPR spectra, suggesting, consistent with the EPR and dc magnetic susceptibility, weak antiferromagnetic exchange interactions. Paramagnetic behavior sustained down to low temperatures is derived for Yb3+ ions, whereas substantial ferromagnetic exchange coupling is inferred for the lighter Nd3+ ions, indicating significant variations of the exchange integrals along the lanthanide series.

A comparative study of powder and bulk specimens of (formula presented) by electron spin resonance (ESR) verifies the presence of intense conduction electron spin resonance (CESR) in the normal state. A low concentration paramagnetic center stemmimg from the initial amoprhous boron powder along with traces of (formula presented) impurities are identified in the ESR spectra. Intense microwave absorption, that distorts CESR below (formula presented) is observed in fine powders implying enhanced microwave dissipation due to the viscous flux motion. © 2002 The American Physical Society.

A comparative study of powder and bulk specimens of MgB2 by electron spin resonance (ESR) verifies the presence of intense conduction electron spin resonance (CESR) in the normal state. A low concentration paramagnetic center stemmimg from the initial amoprhous boron powder along with traces of Fe3+ impurities are identified in the ESR spectra. Intense microwave absorption, that distorts CESR below Tc, is observed in fine powders implying enhanced microwave dissipation due to the viscous flux motion.

The chapter covers the electronic health record and electronic health record system that facilitates the use of EHR. The EHR is compared with the traditional handwritten health care record. Definition of Electronic Health Records and its association with the terminology, classification and coding is presented. The architecture of the Electronic Health Record is of strong significance as well as its attributes. Strategic approaches of designing systems supporting the use of electronic health records are depicted. A short presentation of current state of implementation and the obstacles for further implementation are given in the final part of the chapter.

This paper is a preliminary study of an extensive project that will take place at Corfu island (Northern island of Ionian Sea), involving the municipality of Esperion and the Remote Sensing Laboratory (University of Athens). The project’s purpose is to estimate the erosion progress at Sidari bay’s (North part of Corfu island) coastal zone, due to wave activity. Sidari area consists of Neogene formations, which are extremely vulnerable. Moreover, wave impact is also of high energy, causing subsidence of the coastal line. Through this project, our team is developing a GIS database that holds information, deriving from existing maps, bibliographical references, and climatological logs, related to geology, geomorphology and environmental parameters. Apart from those data, aerial photography stereo observation and extensive D-GPS fieldwork resulted to continual coastline monitoring and GIS database updating, for a period of 26 and 5 years, respectively.Project’s conclusions are based on quantitative and spatial analysis through GIS, giving answers on the erosion’s rate, the erosion’s impact on human activities and structures, and finally an estimation on Sidari’s coastal zone future morphology.

A retrospective survey of the isolation rate of Enterococcus avium during the period March 1994-February 2000 conducted in Laikon General Hospital using the WHONET software, revealed a peak in the isolation rates of this species during March 1995-February 1996. The ten strains isolated during this time were studied further. No glycopeptide resistance was detected but resistance to ampicillin, ciprofloxacin, erythromycin, gentamicin (high-level) and streptomycin (high-level) was present in nine, ten, nine, three and seven of the isolates, respectively. The genes aac(6')-Ie+aph(2")-Ia and ant(6)-I, encoding for high-level gentamicin and streptomycin resistance, respectively, were detected only in the isolates with the corresponding phenotypes. Beta-lactamase production and haemolysis were not detected. There was evidence of ward-, floor- and building-specific distribution among the different aminoglycoside resistance phenotypes. DNA fingerprinting by PFGE grouped six of the ten isolates in a single cluster with 83% similarity, even though they expressed various resistance phenotypes. These results suggest dissemination of resistance genes among both genetically related and unrelated strains.

In this paper the erosional process of northeastern coastal Attica is studied. The alpine formation, usually Mesozoic limestones and the post-alpine deposits such as conglomerates, sandstones and marl-limestones characterize the geology of this area. This area has dramatically changed in the last decade as a result of a rapid urbanization. In June 2001 this coastal area experienced a severe fire event with enormous effect of the vegetation cover. Apart from this damage the outcropping of post -alpine vulnerable formations might accelerate erosion during possible intense rainfall. All these taken under consideration turned us to the construction of an erosion risk map based on web-GIS and soft computing technology. Such approach can be very useful for regional planning and environmental management. Indeed since our first abstract (September, 2001) heavy precipitation has been occurred (November, 2001) and a vast quantity of the weathering material has been mobilized. This fact and the new data sets have strongly proved the usefulness of this study.

Estimated natural head position, or natural head orientation (NHO), has been proposed as a preferred reference position for assessing facial morphology. However, because this position is subjectively defined by the orthodontist, it could be influenced by facial form, which would be an undesirable attribute. The aim of this study was to assess whether NHO is influenced by facial morphology. Lateral photographs of 14 patients were used. Each was warped to produce 2 new images, with the chin positioned backwards or forwards relative to the original (+/-2 degrees change of the soft tissue N-Pg line). All 42 images were placed in circular frames and shown to 7 experienced orthodontists, who were asked to orient them to NHO. Image orientation between the 3 chin positions was measured and compared. The results showed that NHO depended on chin position. Images with protrusive chins were positioned with the head rotated more downwards (Frankfort plane 3.10 degrees relative to horizontal) than were images with retrusive chins (Frankfort plane 4.98 degrees ). The difference in head orientation measurements was half of the difference in chin position (1.88 degrees for a chin change of 4 degrees ). These findings call into question the validity of NHO for diagnosis because it depends on the same factor it aims to assess. Use of NHO would result in underestimating the true skeletal relationships.

Naxos is the largest island (430km2) οf Cyclades complex. The relief of the island is mountainous, with a central mountain chain crossing it from the north to the south.The geology of Naxos is characterized by a migmatite irruption, metamorphic rocks (schist, gneiss, marble), and sedimentary rocks (Neogenic and Quaternary deposits). Erosion is a complex procedure, which takes place after the forming ofweathered surface material. In this study, an erosion risk map was created, with the use of GIS technology. For this purpose, the maps and fieldwork data concerning the geology of the island, as well as the topography and the geomorphology (of the area) were imported into the GIS. Subsequently, the input data of the final thematicmap were modified with the use of fuzzy logic rules, which was considered to benecessary because of the nature of the studied variables.

Gli sviluppi, dopo la demistificazione del sogno marxista che si è verificata con la caduta del muro di Berlino, lo scioglimento dell’impero sovietico e la rinascità dei nazionalismi regionali, esigono da parte della Comunità Internazionale e dei suoi apparati decisionali un’analisi precisa ed attenta del nuovo paesaggio geopolitico.

The g factors of 21+, 41+, and 22+ states in the stable 130,132,134,136Xe isotopes have been measured via projectile Coulomb excitation in inverse kinematics in combination with the transient field technique. The results show a steady decrease in g(21+) as the number of neutron holes increases in the lighter nuclei below the closed N = 82 neutron shell. The g factors of the 41+ states in 132,134Xe are consistently larger than the g factors of the 21+ states, a characteristic of proton excitation. The g factors of the 21+, 41+, and 22+ states in 130Xe are approximately equal as would be expected for vibrational excitations.

An experimental campaign was carried out on a small Greek island that is characterized by complex terrain: its aim was to study the local characteristics of the vertical structure of the atmospheric boundary layer (ABL). The instrumentation was installed close to the shoreline and consisted of a 13-m-high meteorological mast instrumented at three levels, and a high-range vertical monostatic sodar. Tethered balloon flights were carried out for 3 days under different atmospheric conditions. The analysis of the available data revealed interesting features of the vertical structure of the atmosphere over the island, with the development of a convective internal boundary layer (IBL) within the first 150 m above the ground, while the marine boundary layer (MBL) formed at higher altitudes, up to 450 m. Buoyant oscillations appear within the MBL in the form of gravity waves with frequencies of 7 min. Theoretical calculations of the IBL height verified the experimental results. During the night, a complex wind flow forms in the lower 250-300 m, resulting from the development of katabatic flows and topographic channeling.

Waldenström's macroglobulinemia is a low-grade lymphoplasmacytoid lymphoma characterized by CD20 expression on malignant cells. Several studies have indicated that the anti-CD20 monoclonal antibody rituximab has activity against this disease. Thus, we performed a prospective study in which 17 previously untreated patients with symptomatic macroglobulinemia were treated with rituximab 375 mg/m2 intravenously for 4 weeks. Three months after completion of rituximab, patients without evidence of progressive disease received repeat 4-week courses of this agent. Six patients (35%) achieved a partial response after extended treatment with rituximab. Median time to response was 3 months. The median time to progression (TTP) for all patients was 13 months. One of 6 responding patients has progressed at 10 months, while the other 5 patients remain progression free with a follow-up range of > 22-40 months. Eight patients (47%) were rated as stable disease, and their median TTP was 9 months. Treatment with rituximab was well tolerated and was not associated with myelosuppression; one third of the patients experienced infusion-related toxicity, usually fever and chills of mild degree. Our prospective trial of extended rituximab therapy for previously untreated patients with Waldenström's macroglobulinemia indicates that this agent is active, well tolerated, and might be associated with a long period without the need for further treatment. Studies that will combine rituximab with chemotherapy or with other monoclonal antibodies might be of interest.

We report on time-series photometric observations in the earliest stages of superoutbursts of the extreme dwarf novae, AL Com and WZ Sge, which started on 2001 May after the 6 years quiescence and on 2001 July after the 23 years quiescence, respectively. We detected the growth of ``early superhumps'' during the each rising stage. Our observations reject the mass transfer instability for the trigger of the superoutburst of WZ Sge stars, and show the existence of some relations between the ``early superhumps'' and the spiral structure, which gives a hint of the origin of the ``early superhumps.''

We report on the occurrence of absolute elastic band gaps in three-dimensional binary systems made up of steel spheres in polyester, and examine how the width of such gaps depends on the geometry of the structure.

The primary cause of Duchenne muscular dystrophy (DMD) is a mutation in the dystrophin gene leading to the absence of the corresponding RNA transcript and protein. Absence of dystrophin leads to disruption of the dystrophin-associated protein complex and substantial changes in skeletal muscle pathology. Although the histological pathology of dystrophic tissue has been well documented, the underlying molecular pathways remain poorly understood. To examine the pathogenic pathways and identify new or modifying factors involved in muscular dystrophy, expression microarrays were used to compare individual gene expression profiles of skeletal muscle biopsies from 12 DMD patients and 12 unaffected control patients. Two separate statistical analysis methods were used to interpret the resulting data: t test analysis to determine the statistical significance of differential expression and geometric fold change analysis to determine the extent of differential expression. These analyses identified 105 genes that differ significantly in expression level between unaffected and DMD muscle. Many of the differentially expressed genes reflect changes in histological pathology. For instance, immune response signals and extracellular matrix genes are overexpressed in DMD muscle, an indication of the infiltration of inflammatory cells and connective tissue. Significantly more genes are overexpressed than are underexpressed in dystrophic muscle, with dystrophin underexpressed, whereas other genes encoding muscle structure and regeneration processes are overexpressed, reflecting the regenerative nature of the disease.

In this study we examined the geomorphological and environmental characteristics of south Attika coastal zone (from Voula area to Lagonisi), a region in which man-made influence is very intense. This paper includes the detection of features of the coastal zone, that are in danger of alteration, because of their exposure to human intervention; it results to the study of the above characteristics and their mapping, with a purpose of using the final thematic maps in future study of the area, after the oncoming changes, because of the Olympic games of 2004. For this purpose we developed a database with geographical, geological, geomorphological and environmental characteristics in GIS and we created the corresponding thematic maps. Data collection took place through photointerpretation of corresponding aerial photos and fieldwork of the coastal zone (from inland and offshore) with the use of GPS.

The flat terrestrial part of the coastal zone of the Paros Island (slope <2,5% forelevations 0-50 m), represents only the 19% of the total area of the island (193 km2). More than 75% of the coastal zone consists of high and lower cliffs, whilst relatively flat and sandy (and/or pebble) beaches do not exceed the 17% of the coastline. The island receives a considerable amount of wave energy; this has its highest values (>1500 W/m) at the NE part of the island and its lowest at the SE “protected” and shallower area. Touristic (sandy/pebble) beaches have been developed along those parts of the coastline that characterized by vulnerable lithology associated with moderate wave activity.

In this paper we study Samaria gorge through recognition, recording and visualization of geomorphological characteristics. Geomorphological characteristics collected through Remote Sensing techniques, are compared with those collected through stereoscopic observation of aerial photos and fieldwork. At the first phase, the aerial photos of the studied area were scanned and through selected digital image processing algorithms, the geomorphological characteristics were stressed and recorded. At the second phase a geomorphological map was created based on data derived from stereoscopic observation of the area aerial photos and fieldwork. During fieldwork a GPS was used, which was connected with the GIS in order toimmediately record and test the measured characteristic position. Finally the combination of two methods took place in order to develop a geomorphological map.

BRCA1 and BRCA2 genes were screened for loss-of-function mutations in a series of 85 patients having at least one first- or second-degree relative affected by breast and/or ovarian cancer. All BRCA1 exons and BRCA2 exons 10 and 11 were screened with a combination of methods including SSCP, PTT and direct sequencing. We have found disease-associated mutations in 14 families (16.5%), eleven in BRCA1 and three in BRCA2. The known founder mutation 5382insC of BRCA1 was identified in seven unrelated families. The other mutations identified include the non-sense R1751X, the splice junction variant 5586G>A of BRCA1 and three frameshifts, 2024del5, 3034del4, and 6631del5, of BRCA2. Nine out of these 14 families had a family history of three or more breast/ovarian cancer cases. A large number of polymorphic or unclassified variants is also reported. Combined with our previously published data 5382insC was found in nine out of 20 families (45%), suggesting that this mutation may represent a common founder mutation in the Greek population

Thera, along with the islands of Therasia, Aspronisi, Palaea and Nea Kameni, form avast roundly shaped caldera, of 8x10 km. Because of the intense volcanic activity, The shape and morphology of Thera has repeatedly changed through the years. This characteristic makes Thera, from a geological point of view, a very interesting island. Paleo-environmental and volcanic evolution is quite impressive, moreover if it is expressed through modern technology, such as GIS and modern visualization tools. As far as archaeological findings are concerned, Thera is already famous for the existence of the Minoan civilization. Volcanic activity is highly linked to both thepreservation of the archaeological findings and the destruction of the Minoan civilization over Thera Island. In this study with the use of Geographical Information Systems we propose a wide cultural park, combining all physical, geological, geomorphological and cultural characteristics, and through that the connection between volcanic activity and Minoan civilization evolution.

Un corretto approccio al concetto di Globalizzaziotie esige in via pregiudiziale una definizione, onde evitare false interpretazioni e malintesi che porterebbero a monologhi tra soldi. Si tratta di un fenomeno geografico, osservato su scala internazionale e che riguarda processi di omogeneizzazione su due piani di integrazione: a) sul piano dell’economia internazionalizzata (e non internazionale); b) sul piano della cultura. Suoi meccanismi generartivi e peculiari sono la produzione, la disseminazione ed il controllo (e non la manipolazione) dell’informazione nello spazio geografico internazionale. In uno spazio che si intende quale sintesi dei risultati dialettici remoti della interazione tra lo spazio naturale elementare e lo spazio umano elementare.

BACKGROUND: Recent studies have shown that an abnormal proinflammatory cytokine expression and apoptotic process contribute to adverse left ventricular remodeling and progress of chronic heart failure. This study investigates the effects of growth hormone (GH) administration on serum levels of representative proinflammatory cytokines and soluble apoptosis mediators in patients with chronic heart failure secondary to idiopathic dilated cardiomyopathy (IDC). METHODS: Serum levels of tumor necrosis factor-alpha (TNF-alpha), its soluble receptors (sTNF-RI, sTNF-RII), interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6R), soluble Fas (sFas) and soluble Fas Ligand (sFasL) were determined (enzyme-linked immunosorbent assay method) in 10 patients with IDC (New York Heart Association class III, ejection fraction 24% +/- 2%) before and after a 3-month subcutaneous administration of 4 IU GH every other day (randomized crossover design). Peak oxygen consumption (Vo(2)max) was also used to evaluate the functional status of patients with IDC. RESULTS: Treatment with GH produced a significant reduction in serum levels of TNF-alpha (8.2 +/- 1.2 vs 5.7 +/- 1.1 pg/mL, P <.05), sTNF-RI (3.9 +/- 0.4 vs 3.2 +/- 0.3 ng/mL, P <.05), sTNF-RII (2.6 +/- 0.3 vs 2.2 +/- 0.2 ng/mL, P <.05), IL-6 (5.5 +/- 0.6 vs 4.4 +/- 0.4 pg/mL, P =.05), sIL-6R (32.7 +/- 3.0 vs 28.2 +/- 3.0 ng/mL, P <.05), sFas (4.4 +/- 0.8 vs 3.1 +/- 0.6 ng/mL, P <.05), and sFasL (34.2 +/- 11.7 vs 18.8 +/- 7.3 pg/mL, P <.01). A significant improvement was also observed in VO2max after the completion of 3 months' treatment with GH (15.0 +/- 0.8 vs 17.2 +/- 1.0 mL/kg/min, P <.05). Good correlations were found between GH-induced reduction in TNF-alpha levels and increase in VO2max (r = -0.64, P <.05) as well as between GH-induced reduction in sFasL and increase in VO2max (r = -0.56, P =.08). CONCLUSIONS: GH administration reduces serum levels of proinflammatory cytokines and soluble Fas/FasL system in patients with IDC. These immunomodulatory effects may be associated with improvement in clinical performance and exercise capacity of patients with IDC

In this paper we examine one of the areas where there is a marked difference between Civil and Common contract law, that of the enforcement of liquidated damages and more particularly of penalty clauses. Common law judges are quite reluctant to enforce liquidated damages, especially if they believe that they include penalty clauses which are not enforceable. On the contrary, in almost all European contract laws liquidated damages are readily enforced, as are penalty clauses when they are not manifestly excessive. Although most law & economics scholars have criticized Common law courts for the non-enforcement of penalty clauses, there is a sizable minority of scholars who have defended the Common law non-enforcement policy on the ground that penalty clauses are inefficient because they hinder efficient breach. However, and despite the merits of the arguments advanced by advocates of the non-enforcement of penalty clauses, we believe that Common law's rejection of penalty clauses is inefficient. We further show that the Civil law solution to the problem is not only comparatively more efficient, but that it can also appease the worries of those scholars who are afraid that efficient breaches will be deterred. The solution that Civil law systems give to the problem manages to enforce the parties' wishes and to avoid deterring efficient breaches. However, we point out that in order for the Civil law systems to take advantage of this superiority, the interpretation of their Civil Codes should be guided by economic analysis and the respect to the wishes of the contracting parties.

Water samples were collected for coccolithophore analysis in August 2001, from 8 stations along a transect in the gulf of Korthi (Andros Island, Aegean sea). Samples were collected from 0-120m water-depth to determine the spatial and vertical distribution of individual holococcolithophore species in coastal environments. Holococcolithophore absolute abundances usually range between 7.29x103 and 0.06x103 cells/l. The distribution patternsi ndicate that holococcolithophores may constitute a significant part of the summer flora in the upper photic zone of the coastal waters of Andros island, providing evidence of vertical distribution in the water column and showing affinities to shallower environments and rather normal nutrification conditions.

Water samples were collected for coccolithophore analysis in August 2001, from 8 stations along a transect in the gulf of Korthi (Andros Island, Aegean sea). Samples were collected from 0-120m water-depth to determine the spatial and vertical distribution of individual holococcolithophore species in coastal environments. Holococcolithophore absolute abundances usually range between 7.29x103 and 0.06x103 cells/l. The distribution patternsi ndicate that holococcolithophores may constitute a significant part of the summer flora in the upper photic zone of the coastal waters of Andros island, providing evidence of vertical distribution in the water column and showing affinities to shallower environments and rather normal nutrification conditions.

BACKGROUND: Prolactin represents a stimulatory link between the neuroendocrine and immune systems, but its involvement in the neurohumoral adaptations to heart failure (HF) has not been explored. METHODS: We prospectively studied 55 patients (45 males, 10 females, age 48 +/- 7 years) with NYHA Class II/III HF due either to dilated cardiomyopathy (CMP) (n = 33) or ischemic heart disease (IHD) (n = 22). Serum prolactin levels were determined by radioimmunoassay, soluble interleukin-2 receptor (sIL-2R) levels by enzyme-linked immunoassay and HLA-DQ genotyping with PCR. Left ventricular ejection fraction (LVEF) and end-diastolic diameter (LVEDd) were assessed echocardiographically. RESULTS: Hyperprolactinaemia (17.3 +/- 4 ng mL-1 [Group I] vs. 4.64 +/- 2 ng mL-1 [Group II], P < 0.01) was found in 14 patients (8 with IHD, 6 with CMP). The distribution of HLA-DQB1 alleles was compared in the two groups and showed a significant increase in the frequency of *0301 (86% in Group I vs. 45% in Group II, P < 0.05). Histidine at position 30 of the HLA-DQB1 gene was found in 22% of Group II but in none of Group I patients. Furthermore, there was an inverse correlation between the presence of histidine at position 30 and the levels of serum prolactin. Both sIL-2R levels, a marker of T-cell activation, and concanavalin A-stimulated lymphocyte proliferation were lower in Group I patients (561 +/- 106 vs. 804 +/- 109 pg mL-1 and 20.8 +/- 4 vs. 37.3 +/- 5 cpmX103 [3H] thymidine, respectively). LVEF was significantly higher (32 +/- 5%) and LVEDd smaller (62.0 +/- 6 mm) in Group I compared to Group II (25 +/- 4% and 68.0 +/- 5 mm, respectively, P < 0.01) patients. CONCLUSION: Hyperprolactinaemia presents in 25% of patients with HF and may reflect decreased activation of T-lymphocytes associated with relatively preserved LV systolic function which is under immune-genetic control at the HLA-DQ locus

By means of local Hall probe ac and dc permeability measurements, we investigate the phase diagram of vortex matter for the HgBa2CuO4+delta superconductor in the regime near critical temperature. The second peak line H-sp, in contrast to what is usually assumed, does not terminate at the critical temperature. Our local ac permeability measurements reveal a pronounced hysteretic behavior and thermomagnetic history effects near the onset of the second peak, giving evidence of a phase transition of vortex matter from an ordered qausilattice state to a disordered glass.

To determine the effect of interferon-alpha2b (IFN-alpha2b) on the long-term suppression of hepatitis C virus (HCV) RNA in patients with persistently normal or near normal alanine aminotransferase (ALT) activity, 76 previously untreated patients with serum HCV RNA and ALT levels <1.5 times the upper limit of normal (ULN) were randomized to receive either interferon-alpha2b (IFN-alpha2b) 5 MU three times a week for 24 weeks (n = 37) or no treatment (n = 39). HCV RNA testing was performed at the end of treatment and after a 6-month follow-up period. Intention-to-treat analysis showed that HCV RNA was detected significantly less frequently in treated than in untreated patients, at the end of both treatment and follow-up (43.2% vs. 7.7%, p < 0.001, and 21.6% vs. 5.1%, p = 0.033, respectively). Among treated patients, sustained virologic response was significantly higher in non-1 than in genotype 1 patients (8 of 26 or 30.8% vs. 0 of 11, p = 0.038). According to multiple logistic regression, untreated patients had a 13.5 times greater risk to be HCV RNA-positive compared with treated patients (p = 0.040). ALT levels flared up in 3 treated and 9 untreated patients (p = 0.07), suggesting that these flare-ups are related to the natural course of chronic HCV infection rather than to IFN-alpha2b. Thus, such patients could benefit from an IFN-alpha2b in combination with ribavirin regimen.

The paper aims at understanding the tunneling process in epitaxial magnetic tunnel junctions. Firstly, we stress the importance of the complex band structure of the insulator for the tunneling of the metal electrons. For large insulator thicknesses the tunneling current is carried by very few states, i.e., those states in the gap of the semiconductor having the smallest imaginary component of the k-vector. In the case of GaAs, ZnSe and MgO these are Delta(1)-states at the Gamma-point. Secondly, we discuss the role of resonant interface states for tunneling. Based on simple model calculations and ab initio results we demonstrate that for symmetrical barriers the minority conductance can be dominated in an intermediate thickness range by few `hot spots' in the surface Brillouin zone, arising from resonant interface states. In these hot spots full transmission can still be obtained, when all other states are already strongly attenuated, so that the usual exponential decay can be considerably delayed. (C) 2002 Elsevier Science B.V. All rights reserved.

The computational approach is one of the newest and fastest developing techniques in pharmacokinetics, ADME (absorption, distribution, metabolism, excretion) evaluation, drug discovery and toxicity. However, to date, the software packages devoted to ADME prediction, especially of metabolism, have not yet been adequately validated and still require improvements to be effective. Most are `open' systems, under constant evolution and able to incorporate rapidly, and often easily, new information from user or developer databases. Quantitative in silico predictions are now possible for several pharmacokinetic (PK) parameters, particularly absorption and distribution. The emerging consensus is that the predictions are no worse than those made using in vitro tests, with the decisive advantage that much less investment in technology, resources and time is needed. In addition, and of critical importance, it is possible to screen virtual compounds. Some packages are able to handle thousands of molecules in a few hours. However, common experience shows that, in part at least for essentially irrational reasons, there is currently a lack of confidence in these approaches. An effort should be made by the software producers towards more transparency, in order to improve the confidence of their consumers. It seems highly probable that in silico approaches will evolve rapidly, as did in vitro methods during the last decade. Past experience with the latter should be helpful in avoiding repetition of similar errors and in taking the necessary steps to ensure effective implementation. A general concern is the lack of access to the large amounts of data on compounds no longer in development, but still kept secret by the pharmaceutical industry. Controlled access to these data could be particularly helpful in validating new in silico approaches. (C) 2002 Elsevier Science B.V. All rights reserved.

Monoclonal gammopathy of undetermined significance (MGUS) is a relatively common condition among individuals older than 70 years. The actuarial risk of MGUS progression to an overt plasma cell malignancy (PCM) after 20 years of follow-up has been reported to be as high as 30%. The purpose of this study was to evaluate the incidence and evolution of MGUS in a Greek population: 1564 consecutive patients older than 50 years who were admitted to the Department of Clinical Therapeutics at the University of Athens School of Medicine for various reasons over a 26-month period were evaluated with serum protein electrophoresis. In cases in which a monoclonal protein was detected, a panel of tests was performed to rule out an underlying plasma cell malignancy (PCM). Serum levels of interleukin (IL)-6, IL-6-soluble receptor (IL-6SR), IL-1 beta, and transforming growth factor beta 1 were also measured in the MGUS cases. Patients with MGUS were monitored at regular intervals for evidence of multiple myeloma or other PCMs. The incidence of MGUS was 4% and there was a positive correlation with increasing age. The median value of serum M peak was only 5.3 g/l. After a median follow-up of 71 months, only two patients developed multiple myeloma (60 and 75 months after initial diagnosis). Our data are consistent with those of other epidemiological studies regarding the incidence of MGUS, but the monoclonal protein levels and the probability of evolution to a malignant plasma cell disorder appeared to be lower in our study than in other series. Our data support the hypothesis that individuals with low M peak values require only regular annual follow-up examinations.

The paper discusses several first-order modal logics that extend the classical predicate calculus. The model theory involves possible worlds with world-variable domains. The logics rely on the philosophical tenet known as serious actualism in that within modal contexts they allow existential generalization from atomic formulas. The language may or may not have a sign of identity, includes no primitive existence predicate, and has individual constants. Some logics correspond to various standard constraints on the accessibility relation, whereas others correspond to various constraints on the domains of the worlds. Soundness and strong completeness are proved in every case; a novel method is used for proving completeness.

Comincerò la mia trattazione determinando l’ambito scientifico della Geografia e del suo metodo analitico, quello della Geopolitica, in conformità ai dati contemporanei; terminerò con il problema della definizione della geopolitica contemporanea in quanto ambito scientifico specifico che si inserisce nel quadro delle sue fonti scientifiche geografiche. Il testo che segue è il frutto di una rilettura e di un approccio critico dei dati della Geografia/Geopolitica classica avente come obiettivo quello di definire le nuove grandezze geopolitiche e la loro formazione, di chiarire i metodi geografici e la loro elaborazione, e di tentare di porre nuove basi di una Geografia e di una Geopolitica al servizio della comunità internazionale (affinchè sia possibile che essa in futuro si fondi sul rispetto delle particolarità i culturali e dei diritti politici ed umani). In breve, la mia finalità è la seguente: porre le basi di ciò che mi sembra essere “il compito della Geografia/Geopolitica moderna”.

Cephalonia belongs to Ionian islands and consists of two alpine zones, the pro-apoulia and the Ionian one, and pleiocene and quaternary deposits. In this paper we are developing a land use / land cover map of Cephalonia island and an urban map of Argostoli town, the capital of Cephalonia, using GIS techniques and photointerpretation.

L’atto terroristico dell’11 settembre ha segnato l’inizio di una reazione a catena di avventimenti i quali hanno costituito il casus per l’intervento degli USA in Afghanistan e il colpo ad obiettivi strategici dei Taliban sui suoi territori. In questo processo sono stati coinvolti in maggior misura attori internazionali come la Gran Bretagna e la Francia e in misura minore la Germania e gli altri stati-membri della NATO con l’appoggio morale della Comunità internazionale e sicuramente quello dell’ONU. Riteniamo che il grande vuoto geopolitico di potere venutosi a creare in Medio Oriente e in Asia Centrale in seguito alla caduta del muro di Berlino verrà colmato in questa occasione da un intreccio di influenze, che si compensano fra loro vicendevolmente, di USA, Russia, Gran Bretagna, e in seconda posizione di alcuni stati europei come la Francia, l’Italia e la Germania. Riteniamo, inoltre, che questioni come il problema dei Curdi, quello idrico che riguarda la Siria e la Turchia, ma anche le relazioni siro-israeliane che concernono il problema delle Alture del Golan ed inoltre la graduale instaurazione di rapporti di normalità dell’Occidente, e più in particolare degli USA, con Teheran, entreranno in corso di soluzione. Stimiamo che in questa catena degli asssestamenti occupi un poste importante anche la soluzione del problema Palestinese nonché la sistemazione dell’ammisssione di Cipro nell’Unione Europea, la quale tuttavia verrà giudicata anche in base alla decisa posizione della Grecia di fronte a pressioni provenienti dall’esterno. In conclusione, a nostro parere, tutto questo ciclo di fermenti e di appianamenti delle relazioni tra Stati nella regione favorisce anche la Grecia che può assumere un ruolo positivo in questo divenire e trarne vantaggi considerevoli. Presupposto di ciò, cerò, che la Grecia dimostri una posizione decisa in politica estera e nelle questioni concernenti la sua sovranità nazionale. In assenza di una posizione di questo tipo (oppure nel caso contrario) il nuovo assetto nel Mediterraneo Sud/Orientale sarà catastrofico per gli interessi nazionali di questo Paese, con tutti i riflessi negativi che ne deriverebbero per gli equilibri dell’Unione Europea medesima.

Le but de ce présent ouvrage est d’analyser les rapports entre la Turquie, la Syrie et l’Irak, au moment où ils évoluent sous la pression du problème le plus crucial du Moyen Orient: à savoir le partage entre eux des eaux du Tigre et de l’Euphrate. Après avoir présenté les caractéristiques qualitatives et potentielles des eaux de surface de cette région, nous continuerons par une interprétation du futur rôle géopolitique de la Turquie en tant que pays situé en amont. Le programme GAP de la Turquie est aussi analysé en détail. S’y trouve aussi analysés les multiples formes de chantage diplomatique pratiqué par la Turquie ou qu’elle pratiquera dans un avenir proche sur ses pays voisins, la Syrie et l’Irak, compromettant ainsi la paix dans la région. Le traitement diplomatique du partage des eaux entre ces trois pays très impliqués sera présenté par rapport aux trois composantes: le problème kurde, le problème du pétrole et le problème du Hatay.

Notre article traite de l’oeuvre du peintre Jacques Carrey (1649-1726) et plus particulièrement de ses dessins orientalistes. Après avoir étudié ses dessins conservés au Musée du Louvre, qui n’ont pas encore été analysés par les chercheurs, nous lui attribuons une série de dessins anonymes conservés à la Bibliothèque Gennadius représentant le défilé du Sultan, les officiers et les militaires ottomans. Dans notre étude nous présentons également les artistes du marquis de Nointel et leur production durant son tour en Orient méditerranéen. La comparaison des dessins orientalistes de Jacques Carrey avec ceux qui représentent le Parthénon et les antiquités d’Athènes réalisés durant l’ambassade du marquis de Nointel, nous permet de déduire que leur attribution à Jacques Carrey est problématique. Ensuite nous traitons de la thématique et de la qualité artistique des dessins orientalistes de Carrey, qui sont conservés à la Bibliothèque Gennadius.  Commentés à l’aide des extraits de La Croix, ses dessins mettent en scène le pouvoir de l’armée ottomane. De plus, nous nous référons aux tableaux exécutés par Carrey pour le marquis de Nointel et nous présentons les éléments orientalistes de sa série de peintures relatant la vie de Saint-Pantaléon, qui sont conservés à Troyes. Finalement après avoir comparé deux des dessins de Carrey, conservés au musée du Louvre à des tableaux attribués à  Cornelis de Wael (Drout, 1996), nous contestons leur attribution.

We observed EX Draconis in BV I colours for 40 nights, covering 3 outburst events, with the aim to study the disc evolution. Here, we present a preliminary eclipse-mapping study of some of the B band light curves obtained during the outburst in August 2000.

Recent studies suggest that leptin, the product of the obese gene, is produced by the placenta during pregnancy. The present study addressed the question whether second trimester maternal serum leptin could be altered by fetal Down syndrome or Edwards syndrome. Maternal serum leptin concentrations were measured in 18 pregnancies complicated with Down syndrome, six pregnancies complicated with Edwards syndrome and 183 uncomplicated pregnancies during the second trimester of pregnancy. The present results demonstrate that leptin concentrations in uncomplicated pregnancies slightly decrease from the 16th week of pregnancy, reaching a minimum of 18.8 ng/ml around the 20th week, and then rapidly increase to 28.2 ng/ml by the 24th week. Leptin correlation with maternal body weight decreases from r=0.695 at 16-17 week of gestation to r=0.544 at < 22 weeks of gestation. There was no significant difference between the mean MoMs of Down syndrome- (0.926) or Edwards syndrome- (0.960) affected pregnancies and normal pregnancies (1.002). A weak correlation (r=0.18, p<0.02) was observed between corrected leptin MoMs and human chorionic gonadotrophin (hCG) MoMs in normal pregnancies. It is assumed that around the 20th week of pregnancy placental leptin production is activated or at least is accelerated and it is added to the amount of leptin produced by maternal adipose tissue. Fetal Down syndrome or Edwards syndrome does not seem to alter maternal leptin concentration and therefore leptin cannot be used as a marker for these chromosomal abnormalities in the early second trimester of pregnancy. Copyright © 2002 John Wiley & Sons, Ltd.

Bergeles, Nikos;  Haziharistos, Dimitris and Kamperidou, Rena (Irene).  The Meaning of the Term ‘Team’ (Omada) in the Epic Cycle. Proceedings of the 7th Annual Congress of the European College of Sport Science. Editors Maria Koskolou, Nickos Geladas, Vassilis Klissouras, Volume 2, Athens, 24-28 July, 2002, (0736/ p. 658).

During the last decade multiwavelength observations of blazars have revealed many interesting patterns in their emission across the EM spectrum. In the present article we will review the time-dependent one-zone models and the models which advocate an acceleration and a radiation zone, and we will make some comparisons between them, especially in light of recent observations of the so-called TeV blazars.

OBJECTIVE: To describe the use of large-scale gene expression profiles to distinguish broad categories of myopathy and subtypes of inflammatory myopathies (IM) and to provide insight into the pathogenesis of inclusion body myositis (IBM), polymyositis, and dermatomyositis. METHODS: Using Affymetrix GeneChip microarrays, the authors measured the simultaneous expression of approximately 10,000 genes in muscle specimens from 45 patients in four major disease categories (dystrophy, congenital myopathy, inflammatory myopathy, and normal). The authors separately analyzed gene expression in 14 patients limited to the three major subtypes of IM. Bioinformatics techniques were used to classify specimens with similar expression profiles based on global patterns of gene expression and to identify genes with significant differential gene expression compared with normal. RESULTS: Ten of 11 patients with IM, all normals and nemaline myopathies, and 10 of 12 patients with Duchenne muscular dystrophy were correctly classified by this approach. The various subtypes of inflammatory myopathies have distinct gene expression signatures. Specific sets of immune-related genes allow for molecular classification of patients with IBM, polymyositis, and dermatomyositis. Analysis of differential gene expression identifies as relevant to disease pathogenesis previously reported cytokines, major histocompatibility complex class I and II molecules, granzymes, and adhesion molecules, as well as newly identified members of these categories. Increased expression of actin cytoskeleton genes is also identified. CONCLUSIONS: The molecular profiles of muscle tissue in patients with inflammatory myopathies are distinct and represent molecular signatures from which diagnostic insight may follow. Large numbers of differentially expressed genes are rapidly identified.

We analyse 37 RXTE observations of the type 2 Seyfert galaxy Mrk 348 obtained over a period of 14 months. We confirm the spectral variability previously reported by Smith, Georgantopoulos & Warwick, in the sense that the column density decreases by a factor of ~3 as the count rate increases. Column density variations could possibly originate either from the random drift of clouds within the absorption screen, or from photoionization processes. Our modelling of the observed variations implies that the first scenario is more likely. These clouds should lie within a distance of >2 light-years from the source, having a diameter of a few light-days and a density of >107 cm-3 , hence probably residing outside the broad-line region.

The morphotectonic structure of the North Aegean Basin is studied on the basis of a new detailed swath bathymetric survey. The resulting bathymetric map is presented in reduction with 20-m isobaths. The slope analysis gives an accurate scheme of the geometry of the basin and distinction of several sub-basins (approximately 20). The overall basin geometry is a rectangular tetrahedron shaped by the major slope discontinuity separating the continental platform from the continental slope. The area distribution with depth shows a maximum at depths between 300 and 450 m along the sub-horizontal edge of the continental platform and at depths between 1000 and 1200 m at the basinal areas of the sub-basins. The separation of the western part of the North Aegean Basin from the eastern part (Saros Bay) is very clear in the area between Limnos and Thasos, with a maximum depth of 490 m. The 3.2% of the basin area is characterized by slope values >20%, which correspond to active fault zones. Their trend is NE-SW (N46o) and NW-SE (N136o). Some secondary E-W faults are also present within the basin with morphological expression only on the orientation of slopes <1%, reflecting deformation of the flat-lying deep parts of the basin’s interior. The overall geometry and inferred kinematics of the basin show an increase of both the vertical and horizontal components of the movement at the SW corner of the basin, where an opening of 40 km and a subsidence of 1600 m are contrasted to an opening of 20 km and a subsidence of 1000 m at the NE margin. The GPS data of the area showing an opening of 30 mm/yr are compatible with the above cumulative deformation for a neotectonic period of 4-5 Ma.

Objective: To evaluate postpartum MCH changes in the early postpartum period, and to examine whether neonatal MCA is related to that in maternal serum (MS) or milk. Study design: MCA was measured by EIA on the second and fifth postpartum day in serum and BM from 30 lactating women and their single term neonates. Sera from 20 healthy women (controls), were also analyzed. Results: All neonatal antigen concentrations were below the cut-off level for MCA (11ng/ml). MS MCA was significantly increased compared with that in controls (P<0.00001), while antigen values in BM were highly elevated (P<0.00001), with a significant increase (P<0.0003) from the second to the fifth postpartum day. A strong correlation was found between the second and fifth day postpartum samples in MS, neonatal serum and BM MCA concentrations (rs=0.94, P<0.00001; rs=0.75, P<0.00001 and rs=0.69, P<0.0001, respectively). A significant correlation was also found in MCA values on the fifth postpartum day between neonatal serum and BM (rs=0.54, P<0.02). Conclusions: From these findings one may speculate on some ripening process in milk production and a possible transition of MCA from the neonatal gastro-intestinal tract into circulation. © 2002 Elsevier Science Ireland Ltd. All rights reserved.

Purpose. To explore the quantitative structure pharmacokinetic relationships of the disposition parameters: clearance (CL), apparent volume of drug distribution (V-ap), fractal clearance (CLf), and fractal volume (v(f)) for 272 structurally unrelated drugs used in therapeutics. Methods. Literature data were used for CL and V-ap whereas CLf and v(f) were estimated as described previously (Pharm. Res. 18, 1056, 2001 and 19, 697, 2002). A variety of molecular descriptors expressing lipophilicity, ionization, molecular size and hydrogen bonding capacity were estimated using computer packages. The data were analyzed using multivariate statistics. For each disposition parameter (CL, V-ap, CLf, v(f)) PCA (principal component analysis) and PLS (projection to latent structures) were applied to the total set of data as well as to subsets of data. Results. Drugs were divided into two classes (I and II) according to their v(f) /V-ap ratio. Class I comprises 131 drugs with v(f) /V-ap >1, whereas class II 141 drugs with v(f) /V-ap < 1. After initial PLS analysis, class I was subdivided in subclusters I-a (30 drugs) and I-b (101 drugs). It was found that Ia included mostly acidic drugs with high protein binding, whereas class II comprises mainly basic, lipophilic compounds. No correlation was found between CL, V-ap, CLf and the used descriptors. Adequate PLS models were derived for v(f) considering subclusters I-a, I-b and class II separately. The low v(f) values of class I-a drugs were affected negatively from molecular size descriptors and non- polar surface area. For class I-b drugs with intermediate v(f) values, apparent lipophilicity contributed positively, although molecular size descriptors and polarity were inhibitory factors. The high v(f) values of class II drugs were positively dependent on intrinsic lipophilicity and increased basicity, whereas polarity entered with negative contribution. Conclusions. The parameters V-ap, CL, and CLf fail to reflect the physicochemical properties of drugs. The transformation of V-ap values to v(f) is the underlying cause for the valid models for v(f). These models allow a global consideration of molecular properties (lipophilicity, ionization, molecular size, polar surface area) which govern the distribution of drugs in the human body. The present study provides additional evidence for the physiologically sound concept of v(f)

On 7 September 1999 at 11:56 GMT a destructive earthquake (Mw = 6.0) occurred close to Athens (Greece). The rupture process is examined using data from the Cornet local permanent network, as well as teleseismic recordings. Data recorded by a temporary seismological network were analyzed to study the aftershock sequence. The mainshock was relocated at 38.105°N, 23.565°E, about 20 km northwest of Athens. Four foreshocks were also relocated close to the mainshock. The modeling of teleseismic P and SH waves provides a well-constrained focal mechanism of the mainshock (strike = 105°, dip = 55° and rake = -80°) at a depth of 8 km and a seismic moment M0 = 1.01025 dyn·cm. The obtained fault plane solution represents normal faulting indicating an almost north-south extension. More than 3500 aftershocks were located, 1813 of which present RMS < 0.1 s and ERH, ERZ < 1.0 km. Two main clusters were distinguished, while the depth distribution is concentrated between 2 and 11 km. Over 1000 fault plane solutions of aftershocks were constrained, the majority of which also correspond to N–S extension. No surface breaks were observed but the fault plane solution of the mainshock is in agreement with the tectonics of the area and with the focal mechanisms obtained by aftershocks. The hypocenter of the mainshock is located on the deep western edge of the fault plane. The relocated epicenter coincides with the fringe that represents the highest deformation observed on the differential interferometric image. The calculated source duration is 5 sec, while the estimated dimensions of the fault are 15 km length and 10 km width. The source process is characterized by unilateral eastward rupture propagation, towards the city of Athens. An evident stop phase observed in the recordings of the Cornet local stations is interpreted as a barrier caused by the Aegaleo Mountain.

Arbitrary null-subject constructions are a common property of null- subject languages. Their semantic and syntactic properties have been studied in the Principles and Parameters framework and have been attributed to the assignment of an arbitrary index at the Logical Form as a consequence of their licensing by the interaction of theta and case theory at the level of Deep Structure. In this paper we review the semantic and syntactic properties of arbitrary null-subjects in Greek and we try to analyse these properties in terms of the more general licensing principles of null-subjects and indefiniteness.

Nursing Information System (NIS) is a part of a health care information system that deals with nursing aspects, particularly the maintenance of the nursing record. The several objectives that a Nursing Information system should meet in order to succeed its aims, cover the users' needs and operate properly are described. The functions of such systems, which combine with the basic tasks of the nursing care process, are examined. As Nursing Information System is part of the health care and hospital information system, the different strategies and approaches for designing and developing Hospital Information Systems followed from the decade of 1970 until the recent decade of 1990, are presented. The three main approaches followed were the "centralized approach", the "departmental approach", and the "distributed approach". The advantages and drawbacks of each different approach are examined. For the implementation or upgrade of Nursing Information System a NIS committee comprised by different health care professionals, is necessary to be formed. The implementation and upgrade of a Nursing Information System follows some specific phases. These steps, include planning phase, analysis phase, design phase, development phase, implementation phase, and upgrade phase. A paragraph at the end of this chapter summarizes the future trends of Nursing Information Systems.

After the unexpected superoutburst of WZ Sge on July 23, 2001, the light curve was dominated by the orbital variability with a switch to dominating superhumps after August 5. The time series analysis of our data has shown, that the superhumps have started at the early stage of the superoutburst.

A series of 99mTcO[SN(R)S][S] complexes carrying the 1-(2-methoxyphenyl)piperazine moiety on the tridentate ligand [SN(R)S] was synthesized. For structural characterization and for in vitro binding assays the analogous oxorhenium complexes were prepared. As demonstrated by appropriate competition binding tests in rat hippocampal preparations, all oxorhenium analogues showed affinity for the 5-HT(1A) receptor binding sites with IC(50) values at the nanomolar range (IC(50)= 5.8-103 nM). All 99mTcO[SN(R)S]/[S] complexes showed significant brain uptake in rats at 2 min p.i. (0.24-1.31% ID). However, a clear correlation between distribution of radioactivity in the brain and distribution of 5-HT(1A) receptors could not be established.

Among the most important aspects of the atmospheric pollution problem are the anthropogenic impacts on the stratospheric ozone layer, the related trends of the total ozone content drop and the solar ultraviolet radiation enhancement at the Earth’s surface level. During September 2002, the ozone hole over the Antarctic was much smaller than in the previous six years. It has split into two separate holes, due to the appearance of sudden stratospheric warming that has never been observed before in the southern hemisphere.The analysis of this unprecedented event is attempted, regarding both the meteorological and photochemical aspects, in terms of the unusual thermal field patterns and the induced polar vortex disturbances.

The 88th Canon of  the Synod in Tullo (Trullo 88), punishing the crime of importing animal at church, remained for centuries at the backstage of canonical research, undermined, forgotten and misunderstood. This survey, brings the canon to the forefront, and spotlights its content as a most singnificant disclosure of the structure and theory of Church Criminal Law. The book is a manual of the General Part of Church Criminal Law: The action, the hypostasis of the crime, reasons of  lifting the unjust, external terms of criminality, criminal liabilty  are investigated in this "byzantine" canon. Last but not least:  a) we analyse how  the General Principle of  placing the Rights  Human Life and Health at the top of the Pyramid of Canonical Protection is provided by the Trullo 88 and is introduced to the whole Canon Law, b) we notice  the fact that the Canon introduces the Evangelic speech about the Sabbath into the field of Church Law, with serious consequences in the "philosophy" (=theology) of Orthodox Canon Law.