Publications

We present ab initio calculations for spin injection in Fe-ZnSe and Fe-GaAs(001) systems, with and without detection by a second Fe lead. We consider the case of hot injection, as well as the presence of a tunneling barrier at the interface. Our calculations are valid in the ballistic regime. We find that these systems can be very efficient spin filters, leading to current spin polarizations and magnetoresistance ratios very close to the ideal 100%.

We calculate the current spin polarization and the interface resistance of Fe/GaAs and Fe/ZnSe (001) spin injection junctions from first principles, including also the possibility of a Schottky barrier. From our results of interface resistance we estimate the barrier thickness needed for efficient spin injection if the process is nonballistic.

Stenotrophomonas maltophilia is rarely implicated in clinical infections but it constitutes a significant nosocomial pathogen, especially in immunocompromised patients. This report describes the first case of a generalised infection caused by S. maltophilia that included bacteremia, wound and respiratory tract infection in a patient suffering from burns. Given the emergence of S. maltophilia nosocomial infections, especially in patients with burns, isolation of the bacterium from blood cultures should prompt the commencement of adequate antibiotic treatment.

Myxopapillary ependymomas (MPEs) are low-grade neuroepithelial tumors typically occurring in the conus-cauda equina-filum terminale region. Limited molecular and cytogenetic analysis of MPEs has not demonstrated consistent abnormalities. In an attempt to clarify the chromosomal status of these tumors and identify commonly aberrant regions in the genome we have combined 3 molecular/cyto/genetic methods to study 17 MPEs. Comparative genomic hybridization of 7/17 tumors identified concurrent gain on chromosomes 9 and 18 as the most frequent finding. The majority of the 17 tumors were also studied using microsatellite analysis with marker spanning the whole chromosomes 9 and 18 and interphase-FISH with centromeric probes for both chromosomes. Our combined results were consistent with concurrent gain in both chromosomes 9 and 18 in 11/17 cases, gain of either chromosome 9 or 18 and imbalance in the other chromosome in 3/17 tumors and allelic imbalances of chromosomes 9 or 18 in 3/17 and 1/17 tumors, respectively. Other abnormalities observed included gain of chromosomes 3, 4, 7, 8, 11, 13, 17q, 20, and X and loss of chromosomes 10 and 22. Our findings represent some steps towards understanding the molecular mechanisms involved in the development of MPE.

Surface deformation and ferroelectric domain switching induced by a force microscope tip on a La-modified PbTiO3 thin film was studied. Polarization switching of the domains comprising the deformed region demonstrated the possibility of using scanning force microscopy (SFM) as a nanoscale tool for imaging phase transitions. It was found that if loading forces are higher than a threshold value, thin film characterization becomes invasive.

Background: Waldenstrom's macroglobulinemia (WM) is an unusual lymphoplasmacytoid lymphoma characterized by the presence of a serum monoclonal immunoglobulin M. Although several studies have evaluated possible prognostic factors of this disease, few have focused on the survival and prognosis of symptomatic patients after the initiation of treatment. Patients and methods: Our study included 122 previously untreated patients with a median age of 67 years who required systemic treatment. Multiple variables were analyzed for their prognostic value on survival after initiation of treatment using univariate and Cox regression multivariate analysis. Results: The median overall survival was 106 months. Pretreatment factors associated with shorter survival were age ≥65 years, splenomegaly, B-symptoms (weight loss, fever or night sweats), hemoglobin <10 g/dl, platelets <100 × 106/dl, albumin <3.5 g/dl and bone marrow lymphoplasmacytic infiltrate ≥50%. In the multivariate analysis, the two variables with independent prognostic value were age ≥65 years and hemoglobin <10 g/dl. Furthermore, we were able to divide our patients into three risk groups based on the presence of two, one or none of these two adverse prognostic factors. The median survival times in the high-, intermediate- and low-risk groups were 46 months, 107 months and 172 months, respectively (P <0.0001). Discussion: Our findings suggest that advanced age and anemia appear to be the two dominant prognostic factors for survival after initiation of treatment in patients with WM. These two readily available parameters can stratify the patients into three distinct subgroups and may help the selection of appropriate treatment.

Six stars out of a sample of ~2300 carbon stars in the Magellanic Clouds have been identified as having strong C2 bands but CN bands that are very weak or absent. It is argued that five of these are likely to be R Coronae Borealis (RCB) stars on the basis of their spectral characteristics and peculiar colours. Most are variables and the Large Magellanic Cloud (LMC) members have extreme radial velocities that are more like the planetary nebula population than the carbon stars. This sample consists of four LMC members (only one of them previously recognized as an RCB star), one Small Magellanic Cloud (SMC) member (the first RCB star reported in the SMC) and one foreground Galactic star.

The synthesis of optically pure long-chain 2-amino-alcohols and 1-O-dodecyl-2-deoxy-2-amino-sn-glycerol was carried out starting from l- or d-Boc-Ser(OBn)-ol by oxidation and consecutive Wittig reaction or etherification reaction. 2-Amino-oleyl alcohol was synthesized by reduction of the corresponding 2-amino-oleic acid. All the long chain amino-alcohols presented interesting inhibition of carrageenin-induced paw edema in rats (ED50 from 0.017 to 0.010 mmol/kg). The synthesis, anti-inflammatory and analgesic activity of long-chain 2-amino-alcohols is reported.

 This review article focuses on the synthesis and reactions of N,N-di-Boc glutamate and aspartate semialdehydes as well as related aldehydes. These building blocks are prepared according to various strategies from glutamic and aspartic acids and find interesting synthetic applications. In the first part, the methods for the synthesis of N,N-di-Boc-amino aldehydes are summarized. The applications of these chiral synthons for the synthesis of unnatural amino acids and other bioactive compounds are discussed in the second section.

The systematics of the first 2+ state g factors in the mass 80 region are investigated in terms of an IBM-II analysis, a pairing-corrected geometrical model, and a shell-model approach. Subshell closure effects at N = 38 and overall trends were examined using IBM-II. A large-space shell-model calculation was successful in describing the behavior for N=4 and N=50 nuclei, where single-particle features are prominent. A schematic truncated-space calculation was applied to the lighter isotopes. The variations of the effective boson g factors are discussed in connection with the role of F-spin breaking, and comparisons are made between the mass 80 and mass 180 regions.

This paper explores the relationship of the perfect with time, in its grammatical expression both as tense and as aspect. While not denying that the perfect has other, non-temporal and non-aspectual uses, while in fact admitting that they are more wide-spread than its time-related uses, it argues that a relationship with time does exist; of the various time-related meanings associated with the perfect it is anteriority that turns out to be more “basic”, in the sense that all the other meanings of the perfect can be derived from it. The article has a strong historical bias: the basic meaning is assumed to have a historical precedence as well as a logical one. 

Recently completed phase II trials and retrospective analyses conducted outside the United States, primarily in Europe and Australia, have confirmed results of landmark US trials that established the efficacy of thalidomide in multiple myeloma. These trials evaluated thalidomide alone or in combination in patients with heavily pretreated relapsed/refractory multiple myeloma. Single-agent thalidomide induced objective responses in approximately one third of patients and prolonged survival by approximately 1 year. These trials also indicated a possible dose-response relationship of thalidomide and identified several poor prognostic factors, including advanced age, high lactose dehydrogenase level, low platelet count, and low hemoglobin level. The combination of thalidomide with dexamethasone increased overall response by approximately 20% and reduced the time to response compared with thalidomide alone. In addition, lower doses of thalidomide used in the combination may increase patient tolerability. Finally, thalidomide in combination with chemotherapy yields response rates of approximately 60%, with median survival times of approximately 18 months. Randomized trials are needed to confirm these results and further explore the role of thalidomide in these treatment settings. © 2003 Elsevier Inc. All rights reserved.

We look for the expected signature of an accretion disc by examining the properties of the Hα emission line versus viewing angle in a sample of 22 superluminal (SL) quasars. The Doppler factor δ, jet velocity γ and viewing angle θ towards the jet are derived from published radio and X-ray data. Most of the Hα spectra (14) have been observed at the United Kingdom Infrared Telescope (UKIRT) and are reported here. About a quarter of the SL objects have weak or absent Hα emission lines, with small equivalent widths (EW). These have high optical polarization, radio core dominance and Doppler factor, and most of them have high apparent SL velocity and low viewing angles. Therefore these weak-EW objects almost certainly have relativistically beamed optical continua. The strong-EW objects also show a clear beaming effect, but a much weaker one, with line EW varying by only a factor of 3 while radio core dominance varies by a factor of several hundred. The correlation of EW with θ is quantitatively in good agreement with the prediction of a flat accretion disc with limb darkening. The weak- and strong-EW sources also show an anticorrelation of line velocity width with the various beaming indicators. Again, the correlation with the derived viewing angle θ shows a quantitative agreement with the effect expected for an axisymmetric structure with velocity dominated by rotation. The line emission cannot come from the surface of the disc, or the line beaming would cancel the continuum beaming. However, it could come from an axisymmetric system of clouds corotating with the accretion disc.

The purpose of this prospective phase II trial was to investigate the safety and efficacy of a modified baseline BEACOPP (bleomycin, etoposide, adriamycin, cyclophosphamide, vincristine, procarbazine, and prednisone) regimen in the treatment of intermediate and advanced stage Hodgkin's disease (HD). From October 1997 to November 2001, 51 consecutive, previously untreated patients with stage IIA (bulky), IIB, III, and IV disease were treated with a modified baseline BEACOPP regimen with the etoposide administered i.v. on day 1 and orally at a dose of 100 mg/m2, on days 2 and 3. Each patient was scheduled to receive eight courses of BEACOPP with consolidation radiotherapy to bulky (≤5 cm) or residual disease. There were 25 males and 26 females with a median age of 32 yr (16-65 yr); 80.3% of the patients had nodular sclerosis HD, 41% had bulky disease (≥5 cm), 10 were in stage IIA (bulky ≥10 cm), 15 in stage IIB, 19 in stage III, and seven in stage IV. Thirty-seven patients (72.5%) achieved a complete response and 17.6% partial response. No significant difference in overall response rate was observed between patients with: (i) 0-2 vs. ≥3 negative prognostic factors, (ii) in stage II vs. stages III/IV, LDH level, and bulky disease. With a median follow up period of 39.5 months, actuarial 3-yr survival rate is 82% and time to progression rate 72.5%. Treatment with this combination was well tolerated. Grades 3 and 4 leukopenia and neutropenia occured in 26% and 28% of the patients, respectively, whereas in 16.3% of the patients infection was observed. Support with granulocyte colony-stimulating factor was given to 59% of the patients. No case of secondary MDS/leukemia has been observed. The results of the present study demonstrate that the modified baseline BEACOPP regimen with radiotherapy used in our patients was well tolerated and effective therapy for intermediate and advanced stage HD. Further follow up time is required to evaluate long-term toxicity.

Background: The efficacy and toxicity of gemcitabine (GEM) and irinotecan (CPT-11) is evaluated in previously untreated patients with inoperable or metastatic pancreatic cancer. Patients and methods: From January 1999 to July 2001, 60 patients with pancreatic cancer (85% stage IV) were enrolled in a two-step extended phase II trial. Patients were treated with gemcitabine (1000 mg/m2 on days 1 and 8) and CPT-11 (300 mg/m2 on day 8) in cycles of 3 weeks. No prophylactic use of recombinant human granulocyte colony-stimulating factor (rhG-CSF) was initially planned. Results: In an intention-to-treat analysis one (1.7%) complete and 14 (23.3%) partial responses were achieved [objective response rate (ORR) 24.7%; 95% confidence interval 14.04% to 35.96%]. Twenty-two (36.7%) and 23 (38.3%) patients had stable and progressive disease, respectively. The median duration of response was 5 months, the median time to tumor progression (TTP) was 7 months and the median overall survival 7 months. One-year survival was 22.5%. Pain improvement and asthenia during treatment were observed in 45% and 43% of patients, respectively; weight gain occurred in 19.5% of patients. Grade 3 anemia occurred in three (5%) patients who required transfusion of six packed red blood cell (RBC) units. Ten (16.7%) additional patients with grade 2 anemia were treated with recombinant erythropoietin. Grade 3 thrombocytopenia occurred in seven (11.7%) patients and grades 3 and 4 neutropenia in 27 (45%). Ten patients developed febrile neutropenia, two of whom died due to sepsis. Prophylactic use of rhG-CSF was eventually required in 93 (28.3%) of 329 administered cycles. Other toxicities were mild. Conclusions: The combination of gemcitabine and irinotecan is an active chemotherapy regimen against pancreatic cancer with a 25% ORR. Toxicity was acceptable for the great majority of patients but with a high percentage of hematopoietic growth factor administration.

Purpose: In 1999, investigators reported promising results of a phase II study of thalidomide in patients with resistant multiple myeloma (MM). Since then, various trials of thalidomide alone and in combination with other agents have been tested in patients with resistant and, more recently, untreated MM. In addition, preliminary results of phase I studies of the immunomodulatory derivatives (IMiDs) of thalidomide have been recently reported. Design: We reviewed and report the results of clinical trials of thalidomide and the IMiDs, as well as the pharmacology, mechanism of action, and toxicity of these agents. Results: Thalidomide has demonstrated significant activity in both resistant and previously untreated multiple myeloma. Combination therapy with dexamethasone increases response rate, even in patients previously resistant to both drugs given as single agents. More recent studies of thalidomide with dexamethasone in previously untreated patients are highly encouraging. The addition of chemotherapy to thalidomide and dexamethasone may further increase response rates, but its effect on patient survival has not been clarified. Preliminary results of trials of IMiD-3 indicate that this agent is active in resistant myeloma and has a toxicity profile different from that of thalidomide. Conclusion: Many studies have confirmed the activity of thalidomide in MM, as well as an improved response with dexamethasone. Newer thalidomide derivatives with reduced toxicity (neuropathy, teratogenicity) are also promising. Thalidomide with dexamethasone may now represent the treatment of choice for previously untreated patients. Further studies with these and other novel agents early in the course of myeloma may improve complete remission rates and frequency of long-term control. © 2003 by American Society of Clinical Oncology.

To evaluate the activity of thalidomide in Waldenstrom's macroglobulinemia (WM), 20 patients were treated on a dose schedule that escalated from 200 mg/d to 600 mg/d. On an intention-to-treat basis, five (25%) patients achieved a partial response, which was noted within 3 months of treatment. Adverse effects were common and prevented dose escalation of thalidomide in 75% of patients and led to premature discontinuation of treatment in 35%. We subsequently evaluated the oral combination of clarithromycin (500 mg twice per day), low-dose thalidomide (200 mg once daily), and dexamethasone (40 mg once per week). Our preliminary analysis on 12 previously treated patients indicate activity of this regimen in WM: three patients achieved a partial response and two patients demonstrated monoclonal protein reduction of greater than 25%. This combination was associated with a variety of side effects due not only to thalidomide, but also to corticosteroids and to clarithromycin. Our preliminary data indicate that this combination may be a useful salvage regimen for some patients with heavily pretreated macroglobulinemia. © 2003 Elsevier Inc. All rights reserved.

Fludarabine is an active agent for the treatment of Waldenstrom's macroglobulinemia (WM) and its combination with cyclophosphamide has been effective in many patients with low-grade lymphoma and chronic lymphocytic leukemia. Based on these data, we administered the combination of fludarabine (25 mg/m2 IV day 1-3) and cyclophosphamide (250 mg/m2 IV day 1 - 3,) to 11 patients with WM. Most patients had features indicating poor prognosis including median age of 73 years (range 60-84 years), hemoglobin <100g/l in 73%, B2-microglobulin >3mg/l in 64%, symptomatic hyperviscosity in 55% of patients. Only 2 patients were previously untreated, 7 were primary refractory and 2 were relapsing on treatment. The fludarabine-cyclophosphamide combination (FC) was administered every 4 weeks for a total of four courses. Partial response, defined by at least 50% reduction of serum monoclonal protein and of tumor infiltrate at all involved sites was documented in 6 patients (55%) (The median time to response was 4 months). Responding patients demonstrated resolution of disease-related symptoms and correction of anemia. Median time to progression for all patients was 24 months. With a mean follow-up of 28 months, two of six responding patients have progressed so far. The probability of 2-year survival is 70%. This regimen was relatively well tolerated. Complications included neutropenia grade 3 or 4 in 3 patients and thrombocytopenia grade 3 or 4 in 2 patients. There were five infectious episodes including two episodes of neutropenic fever. We conclude that the FC combination appears to be active in patients with WM most of whom were resistant to treatment and had poor prognostic factors. The addition of rituximab to FC requires further investigation.

O-tert-Butyldimethylsilylimidazolyl aminals are N,O-acetals that form readily from aldehydes, and although they function as aldehyde stabilizing and protecting groups under various conditions, we report here that they react with organolithium reagents similarly to the parent aldehydes. The mechanism involves the intermediate formation of a 2-imidazolyl anion as is exemplified by the isolation of 2-TBDMS-imidazole. Substitution of the imidazolyl moiety at the 2-position renders these aldehyde derivatives stable to organolithium reagents, thus allowing for the tuning of their reactivity.

O-tert-Butyldimethylsilylimidazolyl aminals are N,O-acetals that form readily from aldehydes, and although they function as aldehyde stabilizing and protecting groups under various conditions, we report here that they react with organolithium reagents similarly to the parent aldehydes. The mechanism involves the intermediate formation of a 2-imidazolyl anion as is exemplified by the isolation of 2-TBDMS-imidazole. Substitution of the imidazolyl moiety at the 2-position renders these aldehyde derivatives stable to organolithium reagents, thus allowing for the tuning of their reactivity.

Background: We investigated the efficacy and safety of 2 cycles of adjuvant chemotherapy with carboplatin, etoposide and bleomycin (CEB 90) in patients with high-risk clinical stage I or stage IM non-seminomatous germ cell tumours (NSGCT). Patients and Methods: A total of 52 consecutive patients (22 patients with high-risk histological features [vascular invasion, presence of embryonal carcinoma, absence of yolk sac tumour] and 30 with tumour marker activity post-orchidectomy-stage IM) were entered into this prospective study. Chemotherapy consisted of carboplatin 400mg/m 2 or AUC 5 (day 1), etoposide 165mg/m2 (days 1-3) and bleomycin 30 mg (days 1, 8, 15). Chemotherapy was repeated every 3 weeks. Results: During a median follow-up of 112 months (range, 10 to 174 months), two patients with stage IM relapsed. These cases had a disseminated, marker-positive germ cell tumour (GCT), extensively involving both liver and lungs in the first case and para-aortic lymph nodes and lung in the second one; both patients died of the tumour after a number of salvage chemotherapy (including high-dose therapy) regimens. Fifty patients (96%) are alive and disease-free. Two cycles of CEB90 were well tolerated and the only side-effects were myelotoxicity and alopecia. Conclusion: Despite the general consensus that ciplatin-based chemotherapy is superior to carboplatin-containing regimens in testicular cancer, 2 cycles of CEB 90 may be an equally effective treatment option as adjuvant therapy for high-risk clinical stage I and IM patients.

Living coccolithophores were collected from eight stations along a transect in the gulf of Korthi (southeastern Andros island, Aegean Sea, Eastern Mediterranean) in August 2001. Samples were collected from 0–120 m water depth to determine the cell density, the species composition and the biogeographical (spatial and vertical) distribution of the coccolithophore biocommunities in coastal marine ecosystems. The studies revealed an impressive heterococcolith–holococcolith combination coccosphere (SEM micrograph) involving the species Algirosphaera robusta and Sphaerocalyptra quadridentata. In addition, a second association was observed by light microscopy. This discovery verifies the suggestions of Kamptner (1941) and provides strong proof on the assignment of these two ‘species’ in a common life cycle, increasing significantly our knowledge of life-cycle pairings ecology.

Living coccolithophores were collected from eight stations along a transect in the gulf of Korthi (southeastern Andros island, Aegean Sea, Eastern Mediterranean) in August 2001. Samples were collected from 0–120 m water depth to determine the cell density, the species composition and the biogeographical (spatial and vertical) distribution of the coccolithophore biocommunities in coastal marine ecosystems. The studies revealed an impressive heterococcolith–holococcolith combination coccosphere (SEM micrograph) involving the species Algirosphaera robusta and Sphaerocalyptra quadridentata. In addition, a second association was observed by light microscopy. This discovery verifies the suggestions of Kamptner (1941) and provides strong proof on the assignment of these two ‘species’ in a common life cycle, increasing significantly our knowledge of life-cycle pairings ecology.

Most of the carbon stars observed with 2dF were selected from the newly completed catalogue of 7760 carbon stars by (Kontizas et al., 2001, Cat. , hereafter KDMK01). (1 data file).

The horizontal and vertical distributions of volatile organic compounds (VOCs) and ozone (O3) concentrations within the lower troposphere over the greater Athens area. Greece, under sea-breeze conditions were studied. Furthermore, an attempt was made to explain the dynamic and chemical mechanisms responsible for the formation of these distributions. Measurements were collected using a specially instrumented Falcon 20-E5 research aircraft, ground-based meteorological instrumentation, and a network of air quality monitoring stations within the context of the Scientific Training and Access to Aircraft for Atmospheric Research Throughout Europe (STAAARTE) 1997 experimental campaign. Relatively high ozone values (55-100 ppbv) were identified within the first 300-400 m above ground, and significantly reduced values were found over the depth of the atmospheric boundary layer. High values of VOC concentrations [150-350 ppbCarbon (C)] were observed near the ground as well as within the first 300 400 m above ground. At higher altitudes, of 1400-1600 m, VOC concentrations remained relatively high (100-200 ppbC). It was demonstrated that the sea-breeze circulation plays a major role in the formation of the above-mentioned concentration levels and that chemical transformations explain specific characteristics.

We report systematic first-principles calculations for ordered zinc-blende compounds of the transition metal elements V, Cr, and Mn with the sp elements N, P, As, Sb, S, Se, and Te, motivated by a recent fabrication of zinc-blende CrAs, CrSb, and MnAs. They show a ferromagnetic half-metallic behavior for a wide range of lattice constants. We discuss the origin and trends of half-metallicity, present the calculated equilibrium lattice constants, and examine the half-metallic behavior of their transition element terminated (001) surfaces.

Η έρευνα εστιάστηκε στην καταγραφή: -των αθλητικών συνηθειών των μαθητών Δημοτικού-Γυμνασίου-Λυκείου, -των απόψεών τους για την επάρκεια της απαιτούμενης αθλητικής υποδομής στην περιοχή μόνιμης διαμονής τους και στο σχολικό τους χώρο, -της κατανομής του ελεύθερου χρόνου για αθλητικές δραστηριότητες,  - των εκφρασμένων αντιλήψεών τους για το μάθημα της Φυσικής Αγωγής και για τη σχέση σχολείου - αθλητικών δραστηριοτήτων.

This study discusses and evaluates the views of Donald W. Winnicott (1896-1971), a distinguished British pediatrician and psychoanalyst, which explicitly or implicitly are related to loneliness and solitude. Α theoretical approach to the developmental origins of loneliness is as yet to be formulated in the field of developmental psychology. Notions such as the capacity to be alone, the good-enough mother, holding and mirroring, true and false self, childhood psychotic isolation, illusion and disillusionment, transitional object and transitional phenomenon, potential space, playing and creative activity, the non-communicating core self, the “journey” from absolute dependence towards independence, etc., are discussed in the light of their implications for the understanding of loneliness and solitude experiences. The exploration and interpretation of these notions show their usefulness in the construction of a developmental model of loneliness and solitude as well as their fruitfulness for further empirical research on this topic.

Ιn diesem Artikel die Besonderheiten des Zweitspracherwerbes hervorgehoben und auf die Bedeutung einer entsprechenden Ausbildung jener Lehrer hingewiesen, die Schüler unterrichten, für die das Neugriechische eine erste, eine zweite oder sogar eine dritte Sozialisationssprache darstellt.

Η εργασία συνιστά μια συμβολή στην πολιτισμική αξιολόγηση των αρχαίων Ολυμπιακών Αγώνων, καθώς είναι αδιαμφισβήτητος ο πολυσήμαντος ρόλος και η καταλυτική παρουσία των αγώνων στον δεδομένο ιστορικό χρόνο. Η πραγματοποίηση των αγώνων σε ένα ‘κέντρο’ αποτελεί κοινό χαρακτηριστικό της αξιολογίας των Ολυμπίων και των άλλων μεγάλων αγώνων της αρχαιότητας, καθώς αυτοί τελούνται σε τόπους οι οποίοι αποτελούν ισχυρά λατρευτικά κέντρα, στα οποία με ενδιάμεσο την θρησκευτική λατρεία η ομάδα έρχεται σε συνάφεια με τους κοινούς θεούς. Η συνεύρεση της ομάδας στα κέντρα αυτά διαμορφώνει το πρωτογενές υλικό αυτού που θ’ αποκαλεστεί αργότερα ως συνείδηση εθνική, καθώς οι ‘εθνικές’ τελετές συνιστούν επικοινωνίες κοινοτήτων και συνύπαρξη πληθυσμών, οι οποίες κατοχυρώνουν ταυτόχρονα και μια πολιτική διαλεκτική, που με τον περίφημο θεσμό της εκεχειρίας αναμφισβήτητα καθορίζει και τον πολιτικό χαρακτήρα των Ολυμπιακών Αγώνων. Η κοινή ειρηνική και ψυχαγωγική συνύπαρξη, χωρίς να υποτιμάται και ο οικονομικός χαρακτήρας της γιορτής, προσδιορίζουν ένα πλαίσιο πολυφωνίας ικανό να δημιουργήσει και να προβάλλει υψηλές φιλοσοφικές και ανθρωπιστικές ιδέες. Ο εναγκαλισμός των αγώνων υπό της τέχνης έρχεται να εκφράσει καλλιτεχνικές και πολιτιστικές αξίες, ολοκληρώνοντας τελικά μέσω της τέχνης την αποτύπωση του κλασικού αθλητή και συνδέοντάς την με την ηθική τελεολογία.

Social Representations of School-Age Children on Drugs Eleni Zymvrakaki, Kyriakos Athanasiou Summary The origins of this work go back to a series of epidemiological surveys conducted over the last twenty years and prove the ever-increasing use of illegal substances among the entire population of Greece (Kokkevi K.a., 1983, Marselos and Frangidis, 1985, Madianou et al., 1987, Dardavesis, 1993, Kokkevi and Stefanis, 1994, Madiano; et al., 1995, Gougouskidis, 2001, Charila and Kalantzi-Azizi, 2001, EKTEPN, 2002a, EKTEPN, 2002b). It is common knowledge that the use of illegal substances is reduced to one of the most important social problems. In Greece too, the problem is exacerbated, as there is an increase in the frequency of deaths from heroin use in the mainly young population, while at the same time observing... Οι απαρχές της εργασίας αυτής ανάγονται σε μια σειρά επιδημιολογικών ερευνών που διεξήχθησαν την τελευταία εικοσαετία και αποδεικνύουν την ολοένα αυξανόμενη χρήση παράνομων ουσιών στο σύνολο του πληθυσμού της Ελλάδας(Κοκκέβη Κ.α., 1983, Μαρσέλος και Φραγκίδης, 1985, Μαδιανού κ.α., 1987, Δαρδαβέσης, 1993, Κοκκέβη και Στεφανής, 1994, Μαδιανό; Κ.α., 1995, Γκουγκουσκίδης, 2001, Χαρίλα και Καλαντζή-Αζίζι, 2001, ΕΚΤΕΠΝ, 2002α, ΕΚΤΕΠΝ, 2002β).Είναι κοινός τόπος ότι η χρήση παράνομων ουσιών ανάγεται σε ένα σε ένα από σημαντικότερα κοινωνικά προβλήματα. Και στην Ελλάδα το πρόβλημα οξύνεται, καθώς παρατηρείται αύξηση της συχνότητας θανάτων από τη χρήση ηρωίνης στο νεανικό κυρίως πληθυσμό, ενώ ταυτόχρονα παρατηρεί τω...

http://www.dardanosnet.gr/book_details.php?id=1041Κωδικός καταλόγου: 402089 ISBN: 978-960-402-089-7 1η ανατύπωση Απρίλιος 2005 (1η έκδοση, Μάιος 2003) 14 x 21 σελ. 451 Κωνσταντίνα Γογγάκη Αντιλήψεις των αρχαίων Ελλήνων για τον Αθλητισμό (Οι) Εκδόσεις: Τυπωθήτω Περίληψη.  Ο αθλητισμός, αποτελώντας ένα τμήμα της κοινωνικής ζωής, επηρεάζει την κοινωνία και επηρεάζεται απ' αυτήν. Έτσι, ο κλασικός αθλητισμός, συνιστώντας μιαν έκφανση της εποχής της ακμής, αντανακλά μιαν από τις πιο δυναμικές πτυχές αυτής της περιόδου. Η σημασία του αθλητισμού, ο πολυσήμαντος ρόλος του, η αγωνιστική νίκη που αποτύπωνει το κλέος και το κύδος των ανδρών, η συγκίνηση του αθλητικού θεάματος, συνδέονται με μερικές από τις καλύτερες στιγμές του δημιουργικού ανθρώπινου πνεύματος. Εκτός, όμως, από την θετική υπάρχει και η αρνητική όψη του αρχαίου αθλητισμού, η οποία επικρίθηκε και καυτηριάστηκε, χωρίς, ωστόσο, να επηρεάσει την εκ μέρους της αρχαίας κοινωνίας αποδοχή του αθλητικού γεγονότος, και η οποία αρνητική όψη επιβεβαιώνει τελικά, εκ του αντιθέτου, τη διαχρονική αξία του μέτρου και της ψυχικής και σωματικής εναρμόνισης. Αυτήν την διττή προσέγγιση, των φωτεινών και των σκοτεινών πλευρών του αρχαίου αθλητισμού, επιχειρεί η παρούσα εργασία, λαμβάνοντας υπ' όψιν τις πηγές της κλασικής παράδοσης. Με τον τρόπο αυτό ξετυλίγεται ένα πλούσιο υλικό, που αποκαλύπτει τις αντιλήψεις των αρχαίων Ελλήνων για τον αθλητισμό, από τον Όμηρο, τον Τυρταίο, τον Πίνδαρο και τον Πλάτωνα, έως τον Γαληνό, τον Φιλόστρατο, τον Παυσανία και τον Λιβάνιο, ενώ, παράλληλα, γίνεται αναφορά σε ορισμένους Ρωμαίους συγγραφείς. Από τη γενική αξιολόγηση του αρχαίου αθλητισμού και τις αντιστοιχίες του στο σύγχρονο αθλητικό γίγνεσθαι, εντέλει αποδεικνύεται πως ο λόγος περί ηθικής και μέτρου στον αθλητισμό είναι όχι μόνον διαχρονικός, αλλά, σήμερα, άκρως αναγκαίος και επίκαιρος. Περιεχόμενα.  Πρόλογος Ανδρέα Μάνου || Εισαγωγή || Οι αθλητικοί αγώνες στην Ιλιάδα και την Οδύσσεια: Μια συγκριτική θεώρηση || Η αγωνιστική νίκη ως αξία στις πινδαρικές ωδές || Η σημασία της νίκης μέσα από τον τύπο του ηττημένου αθλητή κατά τον Πίνδαρο || Προσέγγιση των Πυθίων αγώνων δια της αγγελικής ρήσης στην "Ηλέκτρα" του Σοφοκλή || Η κατά Πλάτωνα "Περί Γυμναστικής" διδασκαλία || Το στεφάνι του νικητή των αγώνων και οι ηθικοί συμβολισμοί του || Το νόημα της ολυμπιακής νίκης στην κλασική αρχαιότητα || Η πολιτισμική αξία των αρχαίων ολυμπιακών αγώνων || Μορφές βίας στα αρχαία αθλήματα || Επικριτικοί λόγοι κατά του αρχαίου αθλητισμού || Γενική βιβλιογραφία || Ευρετήριο ονομάτων || Ευρετήριο εννοιών.

The aim of this study was to investigate school-age children's perceptions and experience of family-related loneliness, and of coping with it. The literature review showed that these dimensions have not been empirically investigated. This study is part of a larger research program that examined children's perceptions of loneliness and its causes, as well as coping with loneliness strategies. Individual interviews were conducted (the interview was constructed on the basis of two pilot studies) and the projective technique of oral story was used with 180 second, fourth and sixth graders. Also, 758 fifth and sixth graders were asked to write a story about loneliness. The samples were randomly chosen from schools in Athens and Piraeus. Children's responses indicating their personal, subjective views of family-related loneliness are discussed within mainly the psychoanalytic developmental framework, and their importance for the construction of a developmental model of loneliness experience in childhood is noted.

Το στεφάνι του νικητή των αγώνων υποδηλώνει την ύπαρξη παλαιών δοξασιών, που κατά την μακρινή πορεία του χρόνου έλαβαν άλλες μορφές ή απωθήθηκαν στο υποσυνείδητο της ανθρωπότητας. Η καταγωγή τους ανάγεται στο βαθύ παρελθόν, τότε που ο πρωτόγονος άνθρωπος ανέπτυσσε τις διάφορες λατρείες στην βάση οτι όλα τ’ άψυχα έχουν ψυχή, κι επομένως το δέντρο και συνεπώς το κλαδί έχουν και μπορούν να μεταδώσουν την θετική δύναμή τους. Οι διάφορες μαγικές και ανιμιστικές θεωρίες γρήγορα ενσωματώνονται στις αγροτικές τελετές που ως σκοπό είχαν την γονιμότητα και την ευφορία της γης. Με την επίδραση του ορθολογικού στοιχείου πάνω στο μαγικό και στο μεταφυσικό, οι δοξασίες αυτές μεταβάλλονται, προσδίδοντας στο στεφάνι και τα κλαδιά ορισμένων δέντρων, όπως η ελιά και η δάφνη, έναν χαρακτήρα ιερό. Έτσι στις ήδη υπάρχουσες δοξασίες κυριαρχούν οι θρησκευτικές αντιλήψεις, του εξαγνισμού και της κάθαρσης, ηθικές αξίες που μεταδίδονται μέσω του ιερού στεφανιού στον νικητή των αγώνων, ο οποίος με τον τρόπο αυτό καθαίρεται, αποκτώντας την ικανότητα επικοινωνίας με το θείον. Κατάλοιπα αυτών των αντιλήψεων επιβιώνουν σήμερα όχι μόνο στο στεφάνι του νικητή των αγώνων, αλλά και σ’ άλλα έθιμα, όπως στο στεφάνι του Μαγιού, στο στεφάνι του γάμου κ.λ.π.  

как письмо в редакцию,  Москва, 2003. (Αναδημοσίευση στην ΠΕΜΠΤΟΥΣΙΑ στις 23/7/2013 στα Ρωσικά) Η δημοσίευση περιλαμβάνει τις κυριότερες θέσεις της διδακτορικής διατριβής για την ηθική θεώρηση της υποβοηθούμενης αναπαραγωγής στο ιατρικό περιοδικό «Ιατρική Βοήθεια» στη ρωσική γλώσσα με τη μορφή γράμματος προς τον εκδότη του περιοδικού (Letter to Editor), στην οποία συνέδραμε ο Ρώσος νευροχειρούργος Boleslav Lichtermann. Η σύνταξη του Ρωσικού περιοδικού ζήτησε τη δημοσίευση των συμπερασμάτων της διατριβής μας για να προβληθούν τα ηθικά διλήμματα που προκύπτουν στις αναπαραγωγικές τεχνολογίες. 

Relative kinetic data were determined for the 5-endo-trig cyclization of radical 12 compared to hydrogen abstraction from (TMS) 3SiH in the temperature range of 344-430 K, which allows for the estimation of a rate constant of 2 × 10 4 s -1 at 298 K with an activation energy of ca. 9 kcal/mol for the cyclization process. The 5-endo-trig cyclization of a variety of radicals that afford five-membered nitrogen-containing heterocycles was addressed computationally at the UB3LYP/6-31G* level. The 5-endo vs 4-exo mode of cyclication and the effect of delocalization of the unpaired electron in the transition state were investigated. Because the ring formed during cyclization contains five sp 2 centers, electrocyclization via a pentadienyl-like resonance form was also considered. For comparison, similar calculations were performed for 4-penten-1-yl and related radicals. The factors that affect the activation energies of homolytic 5-endo-trig cyclization were determined. In the absence of steric or conformational effects, the endo cyclization to form the five-membered ring was strongly favored over exo cyclization to form the four-membered ring not only on thermodynamic grounds but also kinetically. When a substituent on the double bond was able to delocalize the unpaired electron in the transition state of the 4-exo path, the two modes of cyclization became kinetically comparable. These results have an important bearing on the generalization of the Baldwin-Beckwith rules, which classified the 5-endo-trig radical cyclization as a "disfavored" process.

Relative kinetic data were determined for the 5-endo-trig cyclization of radical 12 compared to hydrogen abstraction from (TMS)(3)SiH in the temperature range of 344-430 K, which allows for the estimation of a rate constant of 2 x 10(4) s(-1) at 298 K with an activation energy of ca. 9 kcal/mol for the cyclization process. The 5-endo-trig cyclization of a variety of radicals that afford five-membered nitrogen-containing heterocycles was addressed computationally at the UB3LYP/6-31G* level. The 5-endo vs 4-exo mode of cyclication and the effect of delocalization of the unpaired electron in the transition state were investigated. Because the ring formed during cyclization contains five sp(2) centers, electrocyclization via a pentadienyl-like resonance form was also considered. For comparison, similar calculations were performed for 4-penten-1-yl and related radicals. The factors that affect the activation energies of homolytic 5-endo-trig cyclization were determined. In the absence of steric or conformational effects, the endo cyclization to form the five-membered ring was strongly favored over exo cyclization to form the four-membered ring not only on thermodynamic grounds but also kinetically. When a substituent on the double bond was able to delocalize the unpaired electron in the transition state of the 4-exo path, the two modes of cyclization became kinetically comparable. These results have an important bearing on the generalization of the Baldwin-Beckwith rules, which classified the 5-endo-trig radical cyclization as a "disfavored" process.

CD40 ligand (CD40L, CD154) is overexpressed on T and B cells in systemic lupus erythematosus (SLE). Monocytes have been shown to contribute to immune-mediated pathology in SLE and to express CD40L under certain conditions. Therefore, we studied CD40L expression on lupus monocytes ex vivo, as well as after activation in vitro. A highly significant sevenfold increase in the frequency of CD40L-expressing peripheral monocytes from 23 SLE patients, compared to 16 healthy individuals (mean percentage of CD40L+CD14+ among CD14+ cells, 11.7 versus 1.6), was found by flow cytometry. Increased CD40L expression on monocytes correlated significantly with disease activity, elevated γ-globulin serum levels, as well as increased CD40L expression on T cells. CD40L expression by lupus monocytes was verified at both the mRNA and protein levels, while LPS stimulation was found to upregulate CD40L mRNA accumulation and surface protein expression. CD40L expression on activated lupus monocytes within anti-CD3-stimulated, mononuclear cell cultures was also enhanced compared to control-derived monocytes. These novel findings underscore the multiplicity of pathways through which monocytes may contribute to SLE pathology and suggest that T cell-independent CD40L-mediated cell to cell interactions may be also involved in humoral immune activation in SLE. © 2002 Elsevier Science (USA).

We examined the plasma concentration curve obtained over 6 h after the ingestion of 2 g of creatine (Cr) (equivalent to 2.3 g Cr·H2O) contained in meat or in solution in five non-users of creatine supplements. Peak plasma creatine concentration was lower after the ingestion of meat but was maintained close to this for a longer period. Measurements of the area under the plasma concentration curve indicated approximate bioequivalence of creatine contained in meat with the same dose supplied in a solution. In a separate study, we examined the plasma concentration-time curve after ingestion of solid Cr·H2O. Creatine ingested as a lozenge (crushed in the mouth and swallowed) or as a crystalline suspension in ice cold water resulted in a 20% lower peak concentration and 30-35% smaller area under the plasma creatine concentration curve than the same dose administered in solution. Despite a possibly lower bioavailability, 2.3 g Cr·H2O supplied in either solid form was nonetheless sufficient to raise the plasma concentration five- to six-fold in individuals with a mean body mass of 75.6 kg. We conclude that creatine administered as meat or in solid form is readily absorbed but may result in sligthly lower peak concentrations than when the same dose is ingested as a solution.

We examined the plasma concentration curve obtained over 6 h after the ingestion of 2 g of creatine (Cr) (equivalent to 2.3 g Cr·H2O) contained in meat or in solution in five non-users of creatine supplements. Peak plasma creatine concentration was lower after the ingestion of meat but was maintained close to this for a longer period. Measurements of the area under the plasma concentration curve indicated approximate bioequivalence of creatine contained in meat with the same dose supplied in a solution. In a separate study, we examined the plasma concentration-time curve after ingestion of solid Cr·H2O. Creatine ingested as a lozenge (crushed in the mouth and swallowed) or as a crystalline suspension in ice cold water resulted in a 20% lower peak concentration and 30-35% smaller area under the plasma creatine concentration curve than the same dose administered in solution. Despite a possibly lower bioavailability, 2.3 g Cr·H2O supplied in either solid form was nonetheless sufficient to raise the plasma concentration five- to six-fold in individuals with a mean body mass of 75.6 kg. We conclude that creatine administered as meat or in solid form is readily absorbed but may result in sligthly lower peak concentrations than when the same dose is ingested as a solution.

We examined the plasma concentration curve obtained over 6 h after the ingestion of 2 g of creatine (Cr) (equivalent to 2.3 g Cr·H2O) contained in meat or in solution in five non-users of creatine supplements. Peak plasma creatine concentration was lower after the ingestion of meat but was maintained close to this for a longer period. Measurements of the area under the plasma concentration curve indicated approximate bioequivalence of creatine contained in meat with the same dose supplied in a solution. In a separate study, we examined the plasma concentration-time curve after ingestion of solid Cr·H2O. Creatine ingested as a lozenge (crushed in the mouth and swallowed) or as a crystalline suspension in ice cold water resulted in a 20% lower peak concentration and 30-35% smaller area under the plasma creatine concentration curve than the same dose administered in solution. Despite a possibly lower bioavailability, 2.3 g Cr·H2O supplied in either solid form was nonetheless sufficient to raise the plasma concentration five- to six-fold in individuals with a mean body mass of 75.6 kg. We conclude that creatine administered as meat or in solid form is readily absorbed but may result in sligthly lower peak concentrations than when the same dose is ingested as a solution.

Le pretese continuarono con il successivo Premier turco Yilmaz, che estese la linea di provocazione mettendo in discussione ora lo stesso Trattato di pace di Losanna del 1923, trattato che costituisce il punto di riferimento giuridico obbligato dello status delle frontiere nel Mediterraneo orientale e dintorni. Circa ottanta anni dopo la firma e l’entrata in vigore di quel trattato di pace, il signor Yilmaz asserisce che ci sono “aree grigie” riguardo alla sovranità greca sugli isolotti e scogli dell’Egeo, che egli tuttavia rifiuta persistentemente di definire. Il governo turco ha costantemente respinto le richieste della Comunità internazionale di abbandonare le sue infondate pretese o di portarle davanti alla Corte Internazionale di Giustizia per una risoluzione pacifica. Ora la Turchia, contravvenendo a tutte le norme della legge e della logica, solleva pretese riguardo all’isola greca di Gaudos, il cui status giuridico era già stabilito fin dal 1913, dieci anni prima cioè del trattato di Losanna. In base all’articolo 4 del trattato di pace di Londra del 1913 la Turchia aveva già rinunciato a tutti i diritti di sovranità su Creta e Gaudos. In seguito il trattato di pace di Losanna del 1923 stabilì in modo più specifico le frontiere turche nell’area del Mediterraneo orientale, dal Mar Nero fino alla Persia. Dal momento che vi è compreso il Mare Egeo, il trattato di Losanna stabilisce specificamente che la sovranità turca è mantenuta solo su quelle isole che si trovano entro 3 miglia dalla costa turca, nonché sulle isole di Imbro, Tenedo e Rabbit. Questo regime giuridico nel Mediterraneo orientale è stato rispettato per quasi ottanta anni. Gli improvvisi tentativi turchi rivolti a rigettare, in maniera unilaterale, la validità di tale regime costituiscono una reale e incombente minaccia per la pace e la stabilità dell’intera regione.

The goal of this study is to estimate the relation between air temperature and precipitation in Greece and, thereafter, to define the regions of the covariability of the two parameters. For that purpose, the air temperature and precipitation mean monthly data of 30 meteorological stations, for the period 1950-2000, are analyzed. The first step is the application of Factor Analysis (FA) to each of the two variable groups of the seasonal air temperature and precipitation. The aim is to reduce the number of variables in each group and, more specific, to define the main significant factors for each parameter. The second step is the application of Canonical Correlation Analysis (CCA) to the factor scores of each parameter, derived by the use of PCA, so that the canonical pairs are extracted and the number of the pairs are equal to the minimum number of variables in either set. In the process, the computed canonical scores are correlated to the respective original data, aiming to define regions of positive and negative correlations between the canonical roots of the air temperature and precipitation.

The effect of the synoptic-scale atmospheric circulation on the urban heat island phenomenon over Athens, Greece, was investigated and quantified for a period of 2 yr. employing a neural network approach. A neural network model was appropriately designed and tested for the estimation of the heat island intensity at 23 stations during the examined period. The day-by-day synoptic-scale atmospheric circulation in the lower troposphere for the same period was classified into eight statistically distinct categories. The neural network model employed as an input the corresponding synoptic categories in conjunction with four meteorological parameters that are closely related to the urban heat island. It was found that the synoptic-scale circulation is a predominant input parameter, affecting considerably the heat island intensity. Also, it was demonstrated that the high pressure ridge mostly favors the heat island phenomenon and categories characterized by intense northerly component winds are responsible for its nonappearance or termination.

Benthic foraminifera widespread occurrence, numerical abundance and high fossilization potential rank them among the most powerful biological tools to reconstruct paleoenvironments. Their diversity and composition by suborder sometimes provide a general indication of the past environment, but the benthic taxonomic composition and recognition of faunal assemblages allow more detailed assessments of water depth, intertidal level, salinity, exposure to water turbulence, bottom oxygen concentrations, water temperature and carbon flux. The distribution of benthic foraminifera group is determined, and an analysis of the data is made in an effort to isolate and identify  important relationships between the distribution of organisms studied and the parameters of the physical environment. Benthic Foraminifera of the Upper Pliocene Tsoutsouras section (southern Crete) are analysed in order to investigate their relationship with paleodepth, sediment grain size and climatic changes. This paper encompasses the first detailed quantitative paleoenvironmental analysis based on benthic foraminifera from this area. Q-mode analysis revealed the existence of three associations. A. beccarii-Miliolids association corresponds to a rather shallow marine environment with vegetation in the neighbourhood. A. planorbis-Agglutinants is characterized by a decline in the salinity and the existence of moderate environmental stress which is associated by oxygen depletion and increase of primary productivity. In the upper part of the section V.bradyana – C. carinata association represents theestablishment of a restricted environment with abundant nutrient, where organic matter accumulates and infaunal opportunistic species capable of surviving in stressed conditions dominate.

Benthic foraminifera widespread occurrence, numerical abundance and high fossilization potential rank them among the most powerful biological tools to reconstruct paleoenvironments. Their diversity and composition by suborder sometimes provide a general indication of the past environment, but the benthic taxonomic composition and recognition of faunal assemblages allow more detailed assessments of water depth, intertidal level, salinity, exposure to water turbulence, bottom oxygen concentrations, water temperature and carbon flux. The distribution of benthic foraminifera group is determined, and an analysis of the data is made in an effort to isolate and identify  important relationships between the distribution of organisms studied and the parameters of the physical environment. Benthic Foraminifera of the Upper Pliocene Tsoutsouras section (southern Crete) are analysed in order to investigate their relationship with paleodepth, sediment grain size and climatic changes. This paper encompasses the first detailed quantitative paleoenvironmental analysis based on benthic foraminifera from this area. Q-mode analysis revealed the existence of three associations. A. beccarii-Miliolids association corresponds to a rather shallow marine environment with vegetation in the neighbourhood. A. planorbis-Agglutinants is characterized by a decline in the salinity and the existence of moderate environmental stress which is associated by oxygen depletion and increase of primary productivity. In the upper part of the section V.bradyana – C. carinata association represents theestablishment of a restricted environment with abundant nutrient, where organic matter accumulates and infaunal opportunistic species capable of surviving in stressed conditions dominate.

Benthic foraminifera widespread occurrence, numerical abundance and high fossilization potential rank them among the most powerful biological tools to reconstruct paleoenvironments. Their diversity and composition by suborder sometimes provide a general indication of the past environment, but the benthic taxonomic composition and recognition of faunal assemblages allow more detailed assessments of water depth, intertidal level, salinity, exposure to water turbulence, bottom oxygen concentrations, water temperature and carbon flux. The distribution of benthic foraminifera group is determined, and an analysis of the data is made in an effort to isolate and identify  important relationships between the distribution of organisms studied and the parameters of the physical environment. Benthic Foraminifera of the Upper Pliocene Tsoutsouras section (southern Crete) are analysed in order to investigate their relationship with paleodepth, sediment grain size and climatic changes. This paper encompasses the first detailed quantitative paleoenvironmental analysis based on benthic foraminifera from this area. Q-mode analysis revealed the existence of three associations. A. beccarii-Miliolids association corresponds to a rather shallow marine environment with vegetation in the neighbourhood. A. planorbis-Agglutinants is characterized by a decline in the salinity and the existence of moderate environmental stress which is associated by oxygen depletion and increase of primary productivity. In the upper part of the section V.bradyana – C. carinata association represents theestablishment of a restricted environment with abundant nutrient, where organic matter accumulates and infaunal opportunistic species capable of surviving in stressed conditions dominate.

Benthic foraminifera widespread occurrence, numerical abundance and high fossilization potential rank them among the most powerful biological tools to reconstruct paleoenvironments. Their diversity and composition by suborder sometimes provide a general indication of the past environment, but the benthic taxonomic composition and recognition of faunal assemblages allow more detailed assessments of water depth, intertidal level, salinity, exposure to water turbulence, bottom oxygen concentrations, water temperature and carbon flux. The distribution of benthic foraminifera group is determined, and an analysis of the data is made in an effort to isolate and identify  important relationships between the distribution of organisms studied and the parameters of the physical environment. Benthic Foraminifera of the Upper Pliocene Tsoutsouras section (southern Crete) are analysed in order to investigate their relationship with paleodepth, sediment grain size and climatic changes. This paper encompasses the first detailed quantitative paleoenvironmental analysis based on benthic foraminifera from this area. Q-mode analysis revealed the existence of three associations. A. beccarii-Miliolids association corresponds to a rather shallow marine environment with vegetation in the neighbourhood. A. planorbis-Agglutinants is characterized by a decline in the salinity and the existence of moderate environmental stress which is associated by oxygen depletion and increase of primary productivity. In the upper part of the section V.bradyana – C. carinata association represents theestablishment of a restricted environment with abundant nutrient, where organic matter accumulates and infaunal opportunistic species capable of surviving in stressed conditions dominate.

BACKGROUND: Psychiatric symptoms occur frequently in the course of AD, are a frequent contributor to institutionalization, predict cognitive decline and death, and often require treatment with psychotropic medications. Previous studies investigating the association between APOE genotype and psychiatric symptomatology in AD have reported contradictory results. OBJECTIVE: To determine whether APOE genotype predicts incident psychiatric symptomatology in patients with AD. METHODS: Eighty-seven patients with AD at early stages and no psychiatric history were followed semiannually for up to 9.3 years (mean 5.5 years) for development of delusions, illusions, hallucinations, behavioral symptoms, and depression. Cox proportional hazards models were used to examine the relative risk for incident psychiatric symptomatology (outcome) in relation to APOE genotype (predictor). RESULTS: The presence of one epsilon4 allele carried a 2.5-fold risk, whereas the presence of two epsilon4 alleles carried a 5.6-fold risk for development of delusions. The associations remained significant even when age, ethnicity, sex, education, duration of disease, and cognitive and functional performance were controlled for. The presence of two epsilon4 alleles was associated with reduced risk for developing hallucinations in the adjusted analysis only. No significant associations were detected between APOE genotype and the incidence of illusions, behavioral symptoms, or depression. CONCLUSION: The presence of one or more epsilon4 alleles is a significant predictor for the incidence of delusions in the course of AD.

In this paper we propose a new algorithm for the detection of clustered microcalcifications using mathematical morphology and artificial neural networks. Considering each mammogram as a topographic representation, each microcalcification appears as elevation constituting a regional maxima. Morphological filters are applied, in order to remove noise and regional maxima that doesn't correspond to calcifications. Each suspicious object is marked using a binary image and finally a feed forward neural network classifies every object achieving a rate of 90% true positive detections with 0.11 false positives per image.

We present ab initio calculations of the spin-dependent electronic transport in Fe/GaAs/Fe and Fe/ZnSe/Fe (001) junctions simulating the situation of a spin-injection experiment. We follow a ballistic Landauer-Buttiker approach for the calculation of the spin-dependent dc conductance in the linear-response regime, in the limit of zero temperature. We show that the bulk band structure of the leads and of the semiconductor, and even more the electronic structure of a clean and abrupt interface, are responsible for a current polarization and a magnetoresistance ratio of almost the ideal 100%, if the transport is ballistic. In particular, we study the significance of the transmission resonances caused by the presence of two interfaces.

We consider the spin injection from Fe into ZnSe and GaAs in the ballistic limit. By means of the ab initio screened Korringa-Kohn-Rostoker method we calculate the ground-state properties of epitaxial Fe\textbackslash{}ZnSe(001) and Fe\textbackslash{}GaAs(001) heterostructures. Three injection processes are considered: injection of hot electrons and injection of ``thermal{''} electrons with and without an interface barrier. The calculation of the conductance by the Landauer formula shows that these interfaces act like a nearly ideal spin filter, with spin polarization as high as 99%. This can be traced back to the symmetry of the band structure of Fe for normal incidence.

Determinations of the cadmium content of a wide variety of foodstuffs from the Greek market were carried out. The values detected ranged from <0.1 ng g-1 in alcoholic beverages to 1595.8 ng g-1 in large snails. The highest values were observed in molluscs and crustaceans (117.4ng g-1), followed by leafy vegetables (28.3 ng g-1), potatoes (22.3 ng g-1) and organs and offal (20.7 ng g-1), whereas the other food categories had a lower cadmium content. The results are comparable with those from the rest of Europe. Preliminary analytical data on the cadmium content of food samples of organic cultivation showed significantly lower values compared with those of samples of conventional produce.

This chapter describes all the recent advances in statistical and syntactic pattern recognition, along with a number of the most important hybrid efforts in pattern recognition methodology, which together with structural pattern recognition, are the future trends in pattern recognition applications' schemes.

Objectives. Ifosfamide, paclitaxel, and cisplatin have moderate single-agent activity in patients with metastatic or recurrent cancer of the uterine cervix. We administered a combination of these three agents to a large number of patients with metastatic or recurrent cervical cancer to evaluate its activity. Methods. Sixty patients were treated on an outpatient basis with Ifosfamide (I) 1500 mg/m2 intravenously over 1 h on Days 1-3, paclitaxel (T) 175 mg/m2 as a 3-h intravenous infusion on Day 1, and cisplatin (P) 75 mg/m2 intravenously over 2 h on Day 2 with granulocyte colony-stimulating factor (G-CSF) support. The chemotherapy was repeated every 4 weeks for a maximum of six courses. Results. Fifty-seven patients received at least two courses of treatment and are evaluable for response. Twenty-six patients (46%) achieved an objective response, including 19% complete and 27% partial responses. The median duration of response was 11.5 months and the median time to progression and survival for all patients were 8.3 and 18.6 months, respectively. Patients with excellent performance status, with disease recurrence outside the radiation field, and with nonsquamous tumors had the highest response rate and best survival. Some degree of neurotoxicity occurred in 44% of patients. Grade 3 or 4 toxicity included granulocytopenia in 26% of patients, anemia in 13%, thrombocytopenia in 7%, and neurotoxicity in 3%. Conclusion. The ITP regimen is relatively well tolerated and moderately active in patients with metastatic carcinoma of the uterine cervix. Patients more likely to benefit are those with nonsquamous histology, with excellent performance status, and with disease recurrence outside the radiation field. © 2002 Elsevier Science (USA).

In this paper we are going to develop group replacement policies for a service system by considering the number of customers dynamically in the queue. We consider a service system with multiple independent servers operating in parallel and a single queue. Customers arrive in accordance with a Poisson process, and the service time for each customer follows an exponential distribution. The servers are unreliable with identically exponentially distributed failure times and the repair time is assumed negligible. We formulate this model as a continuous time Markov decision process, and prove the optimal group replacement policy has a threshold structure.

Kamberidou, Irene  (2002). Dance and Physical Activity as a Symbol of Social Inferiority in the Ottoman Empire.  Proceedings of the 7th Annual Congress of the European College of Sport Science. Editors Maria Koskolou, Nickos Geladas, Vassilis Klissouras, Volume 2, Athens, 24-28 July, 2002 (S659/p. 577).[1] [1] Συμμετείχα στο συνέδριο, που οργανώθηκε από την Ελληνική Εταιρεία Αθλητικής Επιστήμης (ΕλΕΑΘλΕ) στην Αθήνα: ως (1) Μoderator στην έναρξη του συνεδρίου, (2) προεδρεύων στο session “Ethics in Sport” και (3) με δύο ανακοινώσεις, σε δύο sessions.

Rhinoviruses (RVs) are the most frequent precipitants of the common cold and asthma exacerbations, but little is known about the immune response to these viruses and its potential implications in the pathogenesis of asthma.|Peripheral blood mononuclear cells (PBMC) from patients with atopic asthma and normal subjects were exposed to live or inactivated RV preparations. Levels of interferon (IFN)gamma and interleukins IL-12, IL-10, IL-4, IL-5 and IL-13 were evaluated in the culture supernatants with specific immunoassays.|Exposure of PBMC to RVs induced the production of IFNgamma, IL-12, IL-10, and IL-13. Cells from asthmatic subjects produced significantly lower levels of IFNgamma and IL-12 and higher levels of IL-10 than normal subjects. IL-4 was induced only in the asthmatic group, while the IFNgamma/IL-4 ratio was more than three times lower in the asthmatic group.|This evidence suggests that the immune response to RVs is not uniquely of a type 1 phenotype, as previously suggested. The type 1 response is defective in atopic asthmatic individuals, with a shift towards a type 2 phenotype in a way similar, but not identical, to their aberrant response to allergens. A defective type 1 immune response to RVs may be implicated in the pathogenesis of virus induced exacerbations of asthma.

We measure single electron movement between two coupled quantum dots each isolated from a reservoir. The electrons movement is detected using a 1-D channel placed next to the double dot system. The electrostatic energy required to move an electron from one dot to a reservoir is half that required to move the electron from one dot to the other dot. We estimate the maximum intra-dot scattering time at < 0.2 ns. This scattering time corresponds to a lifetime broadening equal to the thermal broadening (80 mK) indicating that the scattering time may be longer than this. © 2002 Elsevier Science B.V. All rights reserved.

HBV DNA quantitation is used extensively for the monitoring of treatment of hepatitis B virus (HBV) infection. The aim of this study was to develop a highly sensitive and reproducible real-time PCR (RTD-PCR) assay for the quantitation of HBV DNA using the LightCycler system. The performance of this assay was assessed by analyzing serial dilutions of HBV genomic DNA of known concentration and the lower limit of detection was found to be 1 DNA copy/reaction. By using serial dilutions of plasmid standard, RTD-PCR was determined to quantify HBV DNA in a 10-log10 dynamic range. RTD-PCR was found to be more sensitive than the commercially available tests such as the Quantiplex HBV DNA and the AMPLICOR HBV MONITOR assays. The median coefficient of variation of interexperimental variability was 3.2%. The HBV DNA values obtained with RTD-PCR were highly correlated with assays available commercially. These findings suggest that our RTD-PCR assay combines high sensitivity and reproducibility for HBV DNA quantitation in an incomparable high dynamic range of quantitation.

Scanning force microscopy in the dynamic contact mode with resonance enhanced domain contrast is applied to study in situ pattern formation and relaxation kinetics of ferroelectric domains on the cleavage surface of triglycine sulfate subjected to successive annealing-cooling cycles. Substantial differences in the domain morphology and kinetics are disclosed upon cooling at temperatures close to Tc. Convolution of stripe domains with residual domain nuclei and random pinning forces due to intrinsic defects are suggested to account for variations in the domain structure and slowing down of domain kinetics.

Purpose. (i) Evaluate the predictive performance of the fractal volume of drug distribution, v(f), (Pharm. Res.18, 1056, 2001), (ii) develop the concept of the fractal clearance, CLf, which is the clearance analogue of v(f), (iii) examine the utility of CLf in allometric studies, (iv) develop allometric relationships for the elimination half-life, t(1/2), and (v) evaluate the use of v(f) and CLf in predicting the volume of drug distribution, V-ap, clearance, CL, and elimination half-life, t(1/2). Methods. Estimates for v(f) of various drugs were obtained and correlated with body mass using data only from animal species. A comparison was made between the predicted and actual v(f) values for humans. For a variety of animal species CLf values were estimated from the equation: CLf = v(f)/V-ap CL The allometric equations developed using CLf were compared with other allometric approaches. Allometric equations were also developed for t(1)/2 utilizing the allometric relationships of v(f) and CLf. Results. The predicted estimates of v(f) were very close to the actual values and the correlation exhibited favorable statistical properties. The values of the allometric exponents for CLf were found to be close to 0.75. The predictive performance for CL using the allometric equations for CLf in conjuction with the rule of exponents was found to be better than the currently considered most accurate allometric approaches. The values of the allometric exponents for t(1)/2 were found to be close to 0.25. Conclusion. The predictive ability of v(f) is high; predictions for V(a)p based on v(f) values are better than the current approaches. CLf expressed a good behavior both in prospective and retrospective analysis. The allometric exponents, 0.75, 0.25 for CLf and t(1/2), respectively, agree with the theoretical expected values.

We consider the problem of dynamic admission control in a Markovian loss queueing system with two classes of jobs with different service rates and random revenues. We establish the existence of an optimal monotone policy. We also show that under certain conditions there exist preferred jobs from either class.

This chapter focused on some of the key issues of Health and Nursing Informatics Education. First an historical overview of Health and Nursing Informatics Education is presented. We also describe briefly the activities in the domain of Nursing Informatics Education across Europe. The Special Projects for Health and Nursing Informatics in Europe are presented. Because of the variety of educational systems, the International Medical Informatics Association (IMIA) felt the need to develop international recommendations in health and medical informatics education. From a nursing informatics perspective, the IMIA recommendations in Nursing Informatics Education are discussed.

The magnetic properties of the rare earth molecular compounds with hydrazone ligands containing Nd3+ Gd3+ and Yb3+ have been investigated by electron paramagnetic resonance (EPR) and magnetization measurements. For the Gd-compound, partially resolved fine structure due to Gd and exchange narrowing effects at low temperatures are observed in the EPR spectra, suggesting, consistent with the EPR and dc magnetic susceptibility, weak antiferromagnetic exchange interactions. Paramagnetic behavior sustained down to low temperatures is derived for Yb3+ ions, whereas substantial ferromagnetic exchange coupling is inferred for the lighter Nd3+ ions, indicating significant variations of the exchange integrals along the lanthanide series.

A comparative study of powder and bulk specimens of (formula presented) by electron spin resonance (ESR) verifies the presence of intense conduction electron spin resonance (CESR) in the normal state. A low concentration paramagnetic center stemmimg from the initial amoprhous boron powder along with traces of (formula presented) impurities are identified in the ESR spectra. Intense microwave absorption, that distorts CESR below (formula presented) is observed in fine powders implying enhanced microwave dissipation due to the viscous flux motion. © 2002 The American Physical Society.

A comparative study of powder and bulk specimens of MgB2 by electron spin resonance (ESR) verifies the presence of intense conduction electron spin resonance (CESR) in the normal state. A low concentration paramagnetic center stemmimg from the initial amoprhous boron powder along with traces of Fe3+ impurities are identified in the ESR spectra. Intense microwave absorption, that distorts CESR below Tc, is observed in fine powders implying enhanced microwave dissipation due to the viscous flux motion.

The chapter covers the electronic health record and electronic health record system that facilitates the use of EHR. The EHR is compared with the traditional handwritten health care record. Definition of Electronic Health Records and its association with the terminology, classification and coding is presented. The architecture of the Electronic Health Record is of strong significance as well as its attributes. Strategic approaches of designing systems supporting the use of electronic health records are depicted. A short presentation of current state of implementation and the obstacles for further implementation are given in the final part of the chapter.

This paper is a preliminary study of an extensive project that will take place at Corfu island (Northern island of Ionian Sea), involving the municipality of Esperion and the Remote Sensing Laboratory (University of Athens). The project’s purpose is to estimate the erosion progress at Sidari bay’s (North part of Corfu island) coastal zone, due to wave activity. Sidari area consists of Neogene formations, which are extremely vulnerable. Moreover, wave impact is also of high energy, causing subsidence of the coastal line. Through this project, our team is developing a GIS database that holds information, deriving from existing maps, bibliographical references, and climatological logs, related to geology, geomorphology and environmental parameters. Apart from those data, aerial photography stereo observation and extensive D-GPS fieldwork resulted to continual coastline monitoring and GIS database updating, for a period of 26 and 5 years, respectively.Project’s conclusions are based on quantitative and spatial analysis through GIS, giving answers on the erosion’s rate, the erosion’s impact on human activities and structures, and finally an estimation on Sidari’s coastal zone future morphology.

A retrospective survey of the isolation rate of Enterococcus avium during the period March 1994-February 2000 conducted in Laikon General Hospital using the WHONET software, revealed a peak in the isolation rates of this species during March 1995-February 1996. The ten strains isolated during this time were studied further. No glycopeptide resistance was detected but resistance to ampicillin, ciprofloxacin, erythromycin, gentamicin (high-level) and streptomycin (high-level) was present in nine, ten, nine, three and seven of the isolates, respectively. The genes aac(6')-Ie+aph(2")-Ia and ant(6)-I, encoding for high-level gentamicin and streptomycin resistance, respectively, were detected only in the isolates with the corresponding phenotypes. Beta-lactamase production and haemolysis were not detected. There was evidence of ward-, floor- and building-specific distribution among the different aminoglycoside resistance phenotypes. DNA fingerprinting by PFGE grouped six of the ten isolates in a single cluster with 83% similarity, even though they expressed various resistance phenotypes. These results suggest dissemination of resistance genes among both genetically related and unrelated strains.

In this paper the erosional process of northeastern coastal Attica is studied. The alpine formation, usually Mesozoic limestones and the post-alpine deposits such as conglomerates, sandstones and marl-limestones characterize the geology of this area. This area has dramatically changed in the last decade as a result of a rapid urbanization. In June 2001 this coastal area experienced a severe fire event with enormous effect of the vegetation cover. Apart from this damage the outcropping of post -alpine vulnerable formations might accelerate erosion during possible intense rainfall. All these taken under consideration turned us to the construction of an erosion risk map based on web-GIS and soft computing technology. Such approach can be very useful for regional planning and environmental management. Indeed since our first abstract (September, 2001) heavy precipitation has been occurred (November, 2001) and a vast quantity of the weathering material has been mobilized. This fact and the new data sets have strongly proved the usefulness of this study.

Estimated natural head position, or natural head orientation (NHO), has been proposed as a preferred reference position for assessing facial morphology. However, because this position is subjectively defined by the orthodontist, it could be influenced by facial form, which would be an undesirable attribute. The aim of this study was to assess whether NHO is influenced by facial morphology. Lateral photographs of 14 patients were used. Each was warped to produce 2 new images, with the chin positioned backwards or forwards relative to the original (+/-2 degrees change of the soft tissue N-Pg line). All 42 images were placed in circular frames and shown to 7 experienced orthodontists, who were asked to orient them to NHO. Image orientation between the 3 chin positions was measured and compared. The results showed that NHO depended on chin position. Images with protrusive chins were positioned with the head rotated more downwards (Frankfort plane 3.10 degrees relative to horizontal) than were images with retrusive chins (Frankfort plane 4.98 degrees ). The difference in head orientation measurements was half of the difference in chin position (1.88 degrees for a chin change of 4 degrees ). These findings call into question the validity of NHO for diagnosis because it depends on the same factor it aims to assess. Use of NHO would result in underestimating the true skeletal relationships.

Naxos is the largest island (430km2) οf Cyclades complex. The relief of the island is mountainous, with a central mountain chain crossing it from the north to the south.The geology of Naxos is characterized by a migmatite irruption, metamorphic rocks (schist, gneiss, marble), and sedimentary rocks (Neogenic and Quaternary deposits). Erosion is a complex procedure, which takes place after the forming ofweathered surface material. In this study, an erosion risk map was created, with the use of GIS technology. For this purpose, the maps and fieldwork data concerning the geology of the island, as well as the topography and the geomorphology (of the area) were imported into the GIS. Subsequently, the input data of the final thematicmap were modified with the use of fuzzy logic rules, which was considered to benecessary because of the nature of the studied variables.

Gli sviluppi, dopo la demistificazione del sogno marxista che si è verificata con la caduta del muro di Berlino, lo scioglimento dell’impero sovietico e la rinascità dei nazionalismi regionali, esigono da parte della Comunità Internazionale e dei suoi apparati decisionali un’analisi precisa ed attenta del nuovo paesaggio geopolitico.

The g factors of 21+, 41+, and 22+ states in the stable 130,132,134,136Xe isotopes have been measured via projectile Coulomb excitation in inverse kinematics in combination with the transient field technique. The results show a steady decrease in g(21+) as the number of neutron holes increases in the lighter nuclei below the closed N = 82 neutron shell. The g factors of the 41+ states in 132,134Xe are consistently larger than the g factors of the 21+ states, a characteristic of proton excitation. The g factors of the 21+, 41+, and 22+ states in 130Xe are approximately equal as would be expected for vibrational excitations.

An experimental campaign was carried out on a small Greek island that is characterized by complex terrain: its aim was to study the local characteristics of the vertical structure of the atmospheric boundary layer (ABL). The instrumentation was installed close to the shoreline and consisted of a 13-m-high meteorological mast instrumented at three levels, and a high-range vertical monostatic sodar. Tethered balloon flights were carried out for 3 days under different atmospheric conditions. The analysis of the available data revealed interesting features of the vertical structure of the atmosphere over the island, with the development of a convective internal boundary layer (IBL) within the first 150 m above the ground, while the marine boundary layer (MBL) formed at higher altitudes, up to 450 m. Buoyant oscillations appear within the MBL in the form of gravity waves with frequencies of 7 min. Theoretical calculations of the IBL height verified the experimental results. During the night, a complex wind flow forms in the lower 250-300 m, resulting from the development of katabatic flows and topographic channeling.

Waldenström's macroglobulinemia is a low-grade lymphoplasmacytoid lymphoma characterized by CD20 expression on malignant cells. Several studies have indicated that the anti-CD20 monoclonal antibody rituximab has activity against this disease. Thus, we performed a prospective study in which 17 previously untreated patients with symptomatic macroglobulinemia were treated with rituximab 375 mg/m2 intravenously for 4 weeks. Three months after completion of rituximab, patients without evidence of progressive disease received repeat 4-week courses of this agent. Six patients (35%) achieved a partial response after extended treatment with rituximab. Median time to response was 3 months. The median time to progression (TTP) for all patients was 13 months. One of 6 responding patients has progressed at 10 months, while the other 5 patients remain progression free with a follow-up range of > 22-40 months. Eight patients (47%) were rated as stable disease, and their median TTP was 9 months. Treatment with rituximab was well tolerated and was not associated with myelosuppression; one third of the patients experienced infusion-related toxicity, usually fever and chills of mild degree. Our prospective trial of extended rituximab therapy for previously untreated patients with Waldenström's macroglobulinemia indicates that this agent is active, well tolerated, and might be associated with a long period without the need for further treatment. Studies that will combine rituximab with chemotherapy or with other monoclonal antibodies might be of interest.

We report on time-series photometric observations in the earliest stages of superoutbursts of the extreme dwarf novae, AL Com and WZ Sge, which started on 2001 May after the 6 years quiescence and on 2001 July after the 23 years quiescence, respectively. We detected the growth of ``early superhumps'' during the each rising stage. Our observations reject the mass transfer instability for the trigger of the superoutburst of WZ Sge stars, and show the existence of some relations between the ``early superhumps'' and the spiral structure, which gives a hint of the origin of the ``early superhumps.''

We report on the occurrence of absolute elastic band gaps in three-dimensional binary systems made up of steel spheres in polyester, and examine how the width of such gaps depends on the geometry of the structure.

The primary cause of Duchenne muscular dystrophy (DMD) is a mutation in the dystrophin gene leading to the absence of the corresponding RNA transcript and protein. Absence of dystrophin leads to disruption of the dystrophin-associated protein complex and substantial changes in skeletal muscle pathology. Although the histological pathology of dystrophic tissue has been well documented, the underlying molecular pathways remain poorly understood. To examine the pathogenic pathways and identify new or modifying factors involved in muscular dystrophy, expression microarrays were used to compare individual gene expression profiles of skeletal muscle biopsies from 12 DMD patients and 12 unaffected control patients. Two separate statistical analysis methods were used to interpret the resulting data: t test analysis to determine the statistical significance of differential expression and geometric fold change analysis to determine the extent of differential expression. These analyses identified 105 genes that differ significantly in expression level between unaffected and DMD muscle. Many of the differentially expressed genes reflect changes in histological pathology. For instance, immune response signals and extracellular matrix genes are overexpressed in DMD muscle, an indication of the infiltration of inflammatory cells and connective tissue. Significantly more genes are overexpressed than are underexpressed in dystrophic muscle, with dystrophin underexpressed, whereas other genes encoding muscle structure and regeneration processes are overexpressed, reflecting the regenerative nature of the disease.

In this study we examined the geomorphological and environmental characteristics of south Attika coastal zone (from Voula area to Lagonisi), a region in which man-made influence is very intense. This paper includes the detection of features of the coastal zone, that are in danger of alteration, because of their exposure to human intervention; it results to the study of the above characteristics and their mapping, with a purpose of using the final thematic maps in future study of the area, after the oncoming changes, because of the Olympic games of 2004. For this purpose we developed a database with geographical, geological, geomorphological and environmental characteristics in GIS and we created the corresponding thematic maps. Data collection took place through photointerpretation of corresponding aerial photos and fieldwork of the coastal zone (from inland and offshore) with the use of GPS.

The flat terrestrial part of the coastal zone of the Paros Island (slope <2,5% forelevations 0-50 m), represents only the 19% of the total area of the island (193 km2). More than 75% of the coastal zone consists of high and lower cliffs, whilst relatively flat and sandy (and/or pebble) beaches do not exceed the 17% of the coastline. The island receives a considerable amount of wave energy; this has its highest values (>1500 W/m) at the NE part of the island and its lowest at the SE “protected” and shallower area. Touristic (sandy/pebble) beaches have been developed along those parts of the coastline that characterized by vulnerable lithology associated with moderate wave activity.

In this paper we study Samaria gorge through recognition, recording and visualization of geomorphological characteristics. Geomorphological characteristics collected through Remote Sensing techniques, are compared with those collected through stereoscopic observation of aerial photos and fieldwork. At the first phase, the aerial photos of the studied area were scanned and through selected digital image processing algorithms, the geomorphological characteristics were stressed and recorded. At the second phase a geomorphological map was created based on data derived from stereoscopic observation of the area aerial photos and fieldwork. During fieldwork a GPS was used, which was connected with the GIS in order toimmediately record and test the measured characteristic position. Finally the combination of two methods took place in order to develop a geomorphological map.

BRCA1 and BRCA2 genes were screened for loss-of-function mutations in a series of 85 patients having at least one first- or second-degree relative affected by breast and/or ovarian cancer. All BRCA1 exons and BRCA2 exons 10 and 11 were screened with a combination of methods including SSCP, PTT and direct sequencing. We have found disease-associated mutations in 14 families (16.5%), eleven in BRCA1 and three in BRCA2. The known founder mutation 5382insC of BRCA1 was identified in seven unrelated families. The other mutations identified include the non-sense R1751X, the splice junction variant 5586G>A of BRCA1 and three frameshifts, 2024del5, 3034del4, and 6631del5, of BRCA2. Nine out of these 14 families had a family history of three or more breast/ovarian cancer cases. A large number of polymorphic or unclassified variants is also reported. Combined with our previously published data 5382insC was found in nine out of 20 families (45%), suggesting that this mutation may represent a common founder mutation in the Greek population

Thera, along with the islands of Therasia, Aspronisi, Palaea and Nea Kameni, form avast roundly shaped caldera, of 8x10 km. Because of the intense volcanic activity, The shape and morphology of Thera has repeatedly changed through the years. This characteristic makes Thera, from a geological point of view, a very interesting island. Paleo-environmental and volcanic evolution is quite impressive, moreover if it is expressed through modern technology, such as GIS and modern visualization tools. As far as archaeological findings are concerned, Thera is already famous for the existence of the Minoan civilization. Volcanic activity is highly linked to both thepreservation of the archaeological findings and the destruction of the Minoan civilization over Thera Island. In this study with the use of Geographical Information Systems we propose a wide cultural park, combining all physical, geological, geomorphological and cultural characteristics, and through that the connection between volcanic activity and Minoan civilization evolution.

Un corretto approccio al concetto di Globalizzaziotie esige in via pregiudiziale una definizione, onde evitare false interpretazioni e malintesi che porterebbero a monologhi tra soldi. Si tratta di un fenomeno geografico, osservato su scala internazionale e che riguarda processi di omogeneizzazione su due piani di integrazione: a) sul piano dell’economia internazionalizzata (e non internazionale); b) sul piano della cultura. Suoi meccanismi generartivi e peculiari sono la produzione, la disseminazione ed il controllo (e non la manipolazione) dell’informazione nello spazio geografico internazionale. In uno spazio che si intende quale sintesi dei risultati dialettici remoti della interazione tra lo spazio naturale elementare e lo spazio umano elementare.

BACKGROUND: Recent studies have shown that an abnormal proinflammatory cytokine expression and apoptotic process contribute to adverse left ventricular remodeling and progress of chronic heart failure. This study investigates the effects of growth hormone (GH) administration on serum levels of representative proinflammatory cytokines and soluble apoptosis mediators in patients with chronic heart failure secondary to idiopathic dilated cardiomyopathy (IDC). METHODS: Serum levels of tumor necrosis factor-alpha (TNF-alpha), its soluble receptors (sTNF-RI, sTNF-RII), interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6R), soluble Fas (sFas) and soluble Fas Ligand (sFasL) were determined (enzyme-linked immunosorbent assay method) in 10 patients with IDC (New York Heart Association class III, ejection fraction 24% +/- 2%) before and after a 3-month subcutaneous administration of 4 IU GH every other day (randomized crossover design). Peak oxygen consumption (Vo(2)max) was also used to evaluate the functional status of patients with IDC. RESULTS: Treatment with GH produced a significant reduction in serum levels of TNF-alpha (8.2 +/- 1.2 vs 5.7 +/- 1.1 pg/mL, P <.05), sTNF-RI (3.9 +/- 0.4 vs 3.2 +/- 0.3 ng/mL, P <.05), sTNF-RII (2.6 +/- 0.3 vs 2.2 +/- 0.2 ng/mL, P <.05), IL-6 (5.5 +/- 0.6 vs 4.4 +/- 0.4 pg/mL, P =.05), sIL-6R (32.7 +/- 3.0 vs 28.2 +/- 3.0 ng/mL, P <.05), sFas (4.4 +/- 0.8 vs 3.1 +/- 0.6 ng/mL, P <.05), and sFasL (34.2 +/- 11.7 vs 18.8 +/- 7.3 pg/mL, P <.01). A significant improvement was also observed in VO2max after the completion of 3 months' treatment with GH (15.0 +/- 0.8 vs 17.2 +/- 1.0 mL/kg/min, P <.05). Good correlations were found between GH-induced reduction in TNF-alpha levels and increase in VO2max (r = -0.64, P <.05) as well as between GH-induced reduction in sFasL and increase in VO2max (r = -0.56, P =.08). CONCLUSIONS: GH administration reduces serum levels of proinflammatory cytokines and soluble Fas/FasL system in patients with IDC. These immunomodulatory effects may be associated with improvement in clinical performance and exercise capacity of patients with IDC

In this paper we examine one of the areas where there is a marked difference between Civil and Common contract law, that of the enforcement of liquidated damages and more particularly of penalty clauses. Common law judges are quite reluctant to enforce liquidated damages, especially if they believe that they include penalty clauses which are not enforceable. On the contrary, in almost all European contract laws liquidated damages are readily enforced, as are penalty clauses when they are not manifestly excessive. Although most law & economics scholars have criticized Common law courts for the non-enforcement of penalty clauses, there is a sizable minority of scholars who have defended the Common law non-enforcement policy on the ground that penalty clauses are inefficient because they hinder efficient breach. However, and despite the merits of the arguments advanced by advocates of the non-enforcement of penalty clauses, we believe that Common law's rejection of penalty clauses is inefficient. We further show that the Civil law solution to the problem is not only comparatively more efficient, but that it can also appease the worries of those scholars who are afraid that efficient breaches will be deterred. The solution that Civil law systems give to the problem manages to enforce the parties' wishes and to avoid deterring efficient breaches. However, we point out that in order for the Civil law systems to take advantage of this superiority, the interpretation of their Civil Codes should be guided by economic analysis and the respect to the wishes of the contracting parties.

Water samples were collected for coccolithophore analysis in August 2001, from 8 stations along a transect in the gulf of Korthi (Andros Island, Aegean sea). Samples were collected from 0-120m water-depth to determine the spatial and vertical distribution of individual holococcolithophore species in coastal environments. Holococcolithophore absolute abundances usually range between 7.29x103 and 0.06x103 cells/l. The distribution patternsi ndicate that holococcolithophores may constitute a significant part of the summer flora in the upper photic zone of the coastal waters of Andros island, providing evidence of vertical distribution in the water column and showing affinities to shallower environments and rather normal nutrification conditions.

Water samples were collected for coccolithophore analysis in August 2001, from 8 stations along a transect in the gulf of Korthi (Andros Island, Aegean sea). Samples were collected from 0-120m water-depth to determine the spatial and vertical distribution of individual holococcolithophore species in coastal environments. Holococcolithophore absolute abundances usually range between 7.29x103 and 0.06x103 cells/l. The distribution patternsi ndicate that holococcolithophores may constitute a significant part of the summer flora in the upper photic zone of the coastal waters of Andros island, providing evidence of vertical distribution in the water column and showing affinities to shallower environments and rather normal nutrification conditions.

BACKGROUND: Prolactin represents a stimulatory link between the neuroendocrine and immune systems, but its involvement in the neurohumoral adaptations to heart failure (HF) has not been explored. METHODS: We prospectively studied 55 patients (45 males, 10 females, age 48 +/- 7 years) with NYHA Class II/III HF due either to dilated cardiomyopathy (CMP) (n = 33) or ischemic heart disease (IHD) (n = 22). Serum prolactin levels were determined by radioimmunoassay, soluble interleukin-2 receptor (sIL-2R) levels by enzyme-linked immunoassay and HLA-DQ genotyping with PCR. Left ventricular ejection fraction (LVEF) and end-diastolic diameter (LVEDd) were assessed echocardiographically. RESULTS: Hyperprolactinaemia (17.3 +/- 4 ng mL-1 [Group I] vs. 4.64 +/- 2 ng mL-1 [Group II], P < 0.01) was found in 14 patients (8 with IHD, 6 with CMP). The distribution of HLA-DQB1 alleles was compared in the two groups and showed a significant increase in the frequency of *0301 (86% in Group I vs. 45% in Group II, P < 0.05). Histidine at position 30 of the HLA-DQB1 gene was found in 22% of Group II but in none of Group I patients. Furthermore, there was an inverse correlation between the presence of histidine at position 30 and the levels of serum prolactin. Both sIL-2R levels, a marker of T-cell activation, and concanavalin A-stimulated lymphocyte proliferation were lower in Group I patients (561 +/- 106 vs. 804 +/- 109 pg mL-1 and 20.8 +/- 4 vs. 37.3 +/- 5 cpmX103 [3H] thymidine, respectively). LVEF was significantly higher (32 +/- 5%) and LVEDd smaller (62.0 +/- 6 mm) in Group I compared to Group II (25 +/- 4% and 68.0 +/- 5 mm, respectively, P < 0.01) patients. CONCLUSION: Hyperprolactinaemia presents in 25% of patients with HF and may reflect decreased activation of T-lymphocytes associated with relatively preserved LV systolic function which is under immune-genetic control at the HLA-DQ locus

By means of local Hall probe ac and dc permeability measurements, we investigate the phase diagram of vortex matter for the HgBa2CuO4+delta superconductor in the regime near critical temperature. The second peak line H-sp, in contrast to what is usually assumed, does not terminate at the critical temperature. Our local ac permeability measurements reveal a pronounced hysteretic behavior and thermomagnetic history effects near the onset of the second peak, giving evidence of a phase transition of vortex matter from an ordered qausilattice state to a disordered glass.

To determine the effect of interferon-alpha2b (IFN-alpha2b) on the long-term suppression of hepatitis C virus (HCV) RNA in patients with persistently normal or near normal alanine aminotransferase (ALT) activity, 76 previously untreated patients with serum HCV RNA and ALT levels <1.5 times the upper limit of normal (ULN) were randomized to receive either interferon-alpha2b (IFN-alpha2b) 5 MU three times a week for 24 weeks (n = 37) or no treatment (n = 39). HCV RNA testing was performed at the end of treatment and after a 6-month follow-up period. Intention-to-treat analysis showed that HCV RNA was detected significantly less frequently in treated than in untreated patients, at the end of both treatment and follow-up (43.2% vs. 7.7%, p < 0.001, and 21.6% vs. 5.1%, p = 0.033, respectively). Among treated patients, sustained virologic response was significantly higher in non-1 than in genotype 1 patients (8 of 26 or 30.8% vs. 0 of 11, p = 0.038). According to multiple logistic regression, untreated patients had a 13.5 times greater risk to be HCV RNA-positive compared with treated patients (p = 0.040). ALT levels flared up in 3 treated and 9 untreated patients (p = 0.07), suggesting that these flare-ups are related to the natural course of chronic HCV infection rather than to IFN-alpha2b. Thus, such patients could benefit from an IFN-alpha2b in combination with ribavirin regimen.

The paper aims at understanding the tunneling process in epitaxial magnetic tunnel junctions. Firstly, we stress the importance of the complex band structure of the insulator for the tunneling of the metal electrons. For large insulator thicknesses the tunneling current is carried by very few states, i.e., those states in the gap of the semiconductor having the smallest imaginary component of the k-vector. In the case of GaAs, ZnSe and MgO these are Delta(1)-states at the Gamma-point. Secondly, we discuss the role of resonant interface states for tunneling. Based on simple model calculations and ab initio results we demonstrate that for symmetrical barriers the minority conductance can be dominated in an intermediate thickness range by few `hot spots' in the surface Brillouin zone, arising from resonant interface states. In these hot spots full transmission can still be obtained, when all other states are already strongly attenuated, so that the usual exponential decay can be considerably delayed. (C) 2002 Elsevier Science B.V. All rights reserved.

The computational approach is one of the newest and fastest developing techniques in pharmacokinetics, ADME (absorption, distribution, metabolism, excretion) evaluation, drug discovery and toxicity. However, to date, the software packages devoted to ADME prediction, especially of metabolism, have not yet been adequately validated and still require improvements to be effective. Most are `open' systems, under constant evolution and able to incorporate rapidly, and often easily, new information from user or developer databases. Quantitative in silico predictions are now possible for several pharmacokinetic (PK) parameters, particularly absorption and distribution. The emerging consensus is that the predictions are no worse than those made using in vitro tests, with the decisive advantage that much less investment in technology, resources and time is needed. In addition, and of critical importance, it is possible to screen virtual compounds. Some packages are able to handle thousands of molecules in a few hours. However, common experience shows that, in part at least for essentially irrational reasons, there is currently a lack of confidence in these approaches. An effort should be made by the software producers towards more transparency, in order to improve the confidence of their consumers. It seems highly probable that in silico approaches will evolve rapidly, as did in vitro methods during the last decade. Past experience with the latter should be helpful in avoiding repetition of similar errors and in taking the necessary steps to ensure effective implementation. A general concern is the lack of access to the large amounts of data on compounds no longer in development, but still kept secret by the pharmaceutical industry. Controlled access to these data could be particularly helpful in validating new in silico approaches. (C) 2002 Elsevier Science B.V. All rights reserved.

Monoclonal gammopathy of undetermined significance (MGUS) is a relatively common condition among individuals older than 70 years. The actuarial risk of MGUS progression to an overt plasma cell malignancy (PCM) after 20 years of follow-up has been reported to be as high as 30%. The purpose of this study was to evaluate the incidence and evolution of MGUS in a Greek population: 1564 consecutive patients older than 50 years who were admitted to the Department of Clinical Therapeutics at the University of Athens School of Medicine for various reasons over a 26-month period were evaluated with serum protein electrophoresis. In cases in which a monoclonal protein was detected, a panel of tests was performed to rule out an underlying plasma cell malignancy (PCM). Serum levels of interleukin (IL)-6, IL-6-soluble receptor (IL-6SR), IL-1 beta, and transforming growth factor beta 1 were also measured in the MGUS cases. Patients with MGUS were monitored at regular intervals for evidence of multiple myeloma or other PCMs. The incidence of MGUS was 4% and there was a positive correlation with increasing age. The median value of serum M peak was only 5.3 g/l. After a median follow-up of 71 months, only two patients developed multiple myeloma (60 and 75 months after initial diagnosis). Our data are consistent with those of other epidemiological studies regarding the incidence of MGUS, but the monoclonal protein levels and the probability of evolution to a malignant plasma cell disorder appeared to be lower in our study than in other series. Our data support the hypothesis that individuals with low M peak values require only regular annual follow-up examinations.

The paper discusses several first-order modal logics that extend the classical predicate calculus. The model theory involves possible worlds with world-variable domains. The logics rely on the philosophical tenet known as serious actualism in that within modal contexts they allow existential generalization from atomic formulas. The language may or may not have a sign of identity, includes no primitive existence predicate, and has individual constants. Some logics correspond to various standard constraints on the accessibility relation, whereas others correspond to various constraints on the domains of the worlds. Soundness and strong completeness are proved in every case; a novel method is used for proving completeness.

Comincerò la mia trattazione determinando l’ambito scientifico della Geografia e del suo metodo analitico, quello della Geopolitica, in conformità ai dati contemporanei; terminerò con il problema della definizione della geopolitica contemporanea in quanto ambito scientifico specifico che si inserisce nel quadro delle sue fonti scientifiche geografiche. Il testo che segue è il frutto di una rilettura e di un approccio critico dei dati della Geografia/Geopolitica classica avente come obiettivo quello di definire le nuove grandezze geopolitiche e la loro formazione, di chiarire i metodi geografici e la loro elaborazione, e di tentare di porre nuove basi di una Geografia e di una Geopolitica al servizio della comunità internazionale (affinchè sia possibile che essa in futuro si fondi sul rispetto delle particolarità i culturali e dei diritti politici ed umani). In breve, la mia finalità è la seguente: porre le basi di ciò che mi sembra essere “il compito della Geografia/Geopolitica moderna”.

Cephalonia belongs to Ionian islands and consists of two alpine zones, the pro-apoulia and the Ionian one, and pleiocene and quaternary deposits. In this paper we are developing a land use / land cover map of Cephalonia island and an urban map of Argostoli town, the capital of Cephalonia, using GIS techniques and photointerpretation.

L’atto terroristico dell’11 settembre ha segnato l’inizio di una reazione a catena di avventimenti i quali hanno costituito il casus per l’intervento degli USA in Afghanistan e il colpo ad obiettivi strategici dei Taliban sui suoi territori. In questo processo sono stati coinvolti in maggior misura attori internazionali come la Gran Bretagna e la Francia e in misura minore la Germania e gli altri stati-membri della NATO con l’appoggio morale della Comunità internazionale e sicuramente quello dell’ONU. Riteniamo che il grande vuoto geopolitico di potere venutosi a creare in Medio Oriente e in Asia Centrale in seguito alla caduta del muro di Berlino verrà colmato in questa occasione da un intreccio di influenze, che si compensano fra loro vicendevolmente, di USA, Russia, Gran Bretagna, e in seconda posizione di alcuni stati europei come la Francia, l’Italia e la Germania. Riteniamo, inoltre, che questioni come il problema dei Curdi, quello idrico che riguarda la Siria e la Turchia, ma anche le relazioni siro-israeliane che concernono il problema delle Alture del Golan ed inoltre la graduale instaurazione di rapporti di normalità dell’Occidente, e più in particolare degli USA, con Teheran, entreranno in corso di soluzione. Stimiamo che in questa catena degli asssestamenti occupi un poste importante anche la soluzione del problema Palestinese nonché la sistemazione dell’ammisssione di Cipro nell’Unione Europea, la quale tuttavia verrà giudicata anche in base alla decisa posizione della Grecia di fronte a pressioni provenienti dall’esterno. In conclusione, a nostro parere, tutto questo ciclo di fermenti e di appianamenti delle relazioni tra Stati nella regione favorisce anche la Grecia che può assumere un ruolo positivo in questo divenire e trarne vantaggi considerevoli. Presupposto di ciò, cerò, che la Grecia dimostri una posizione decisa in politica estera e nelle questioni concernenti la sua sovranità nazionale. In assenza di una posizione di questo tipo (oppure nel caso contrario) il nuovo assetto nel Mediterraneo Sud/Orientale sarà catastrofico per gli interessi nazionali di questo Paese, con tutti i riflessi negativi che ne deriverebbero per gli equilibri dell’Unione Europea medesima.

Le but de ce présent ouvrage est d’analyser les rapports entre la Turquie, la Syrie et l’Irak, au moment où ils évoluent sous la pression du problème le plus crucial du Moyen Orient: à savoir le partage entre eux des eaux du Tigre et de l’Euphrate. Après avoir présenté les caractéristiques qualitatives et potentielles des eaux de surface de cette région, nous continuerons par une interprétation du futur rôle géopolitique de la Turquie en tant que pays situé en amont. Le programme GAP de la Turquie est aussi analysé en détail. S’y trouve aussi analysés les multiples formes de chantage diplomatique pratiqué par la Turquie ou qu’elle pratiquera dans un avenir proche sur ses pays voisins, la Syrie et l’Irak, compromettant ainsi la paix dans la région. Le traitement diplomatique du partage des eaux entre ces trois pays très impliqués sera présenté par rapport aux trois composantes: le problème kurde, le problème du pétrole et le problème du Hatay.

Notre article traite de l’oeuvre du peintre Jacques Carrey (1649-1726) et plus particulièrement de ses dessins orientalistes. Après avoir étudié ses dessins conservés au Musée du Louvre, qui n’ont pas encore été analysés par les chercheurs, nous lui attribuons une série de dessins anonymes conservés à la Bibliothèque Gennadius représentant le défilé du Sultan, les officiers et les militaires ottomans. Dans notre étude nous présentons également les artistes du marquis de Nointel et leur production durant son tour en Orient méditerranéen. La comparaison des dessins orientalistes de Jacques Carrey avec ceux qui représentent le Parthénon et les antiquités d’Athènes réalisés durant l’ambassade du marquis de Nointel, nous permet de déduire que leur attribution à Jacques Carrey est problématique. Ensuite nous traitons de la thématique et de la qualité artistique des dessins orientalistes de Carrey, qui sont conservés à la Bibliothèque Gennadius.  Commentés à l’aide des extraits de La Croix, ses dessins mettent en scène le pouvoir de l’armée ottomane. De plus, nous nous référons aux tableaux exécutés par Carrey pour le marquis de Nointel et nous présentons les éléments orientalistes de sa série de peintures relatant la vie de Saint-Pantaléon, qui sont conservés à Troyes. Finalement après avoir comparé deux des dessins de Carrey, conservés au musée du Louvre à des tableaux attribués à  Cornelis de Wael (Drout, 1996), nous contestons leur attribution.

We observed EX Draconis in BV I colours for 40 nights, covering 3 outburst events, with the aim to study the disc evolution. Here, we present a preliminary eclipse-mapping study of some of the B band light curves obtained during the outburst in August 2000.

Recent studies suggest that leptin, the product of the obese gene, is produced by the placenta during pregnancy. The present study addressed the question whether second trimester maternal serum leptin could be altered by fetal Down syndrome or Edwards syndrome. Maternal serum leptin concentrations were measured in 18 pregnancies complicated with Down syndrome, six pregnancies complicated with Edwards syndrome and 183 uncomplicated pregnancies during the second trimester of pregnancy. The present results demonstrate that leptin concentrations in uncomplicated pregnancies slightly decrease from the 16th week of pregnancy, reaching a minimum of 18.8 ng/ml around the 20th week, and then rapidly increase to 28.2 ng/ml by the 24th week. Leptin correlation with maternal body weight decreases from r=0.695 at 16-17 week of gestation to r=0.544 at < 22 weeks of gestation. There was no significant difference between the mean MoMs of Down syndrome- (0.926) or Edwards syndrome- (0.960) affected pregnancies and normal pregnancies (1.002). A weak correlation (r=0.18, p<0.02) was observed between corrected leptin MoMs and human chorionic gonadotrophin (hCG) MoMs in normal pregnancies. It is assumed that around the 20th week of pregnancy placental leptin production is activated or at least is accelerated and it is added to the amount of leptin produced by maternal adipose tissue. Fetal Down syndrome or Edwards syndrome does not seem to alter maternal leptin concentration and therefore leptin cannot be used as a marker for these chromosomal abnormalities in the early second trimester of pregnancy. Copyright © 2002 John Wiley & Sons, Ltd.

Bergeles, Nikos;  Haziharistos, Dimitris and Kamperidou, Rena (Irene).  The Meaning of the Term ‘Team’ (Omada) in the Epic Cycle. Proceedings of the 7th Annual Congress of the European College of Sport Science. Editors Maria Koskolou, Nickos Geladas, Vassilis Klissouras, Volume 2, Athens, 24-28 July, 2002, (0736/ p. 658).

During the last decade multiwavelength observations of blazars have revealed many interesting patterns in their emission across the EM spectrum. In the present article we will review the time-dependent one-zone models and the models which advocate an acceleration and a radiation zone, and we will make some comparisons between them, especially in light of recent observations of the so-called TeV blazars.

OBJECTIVE: To describe the use of large-scale gene expression profiles to distinguish broad categories of myopathy and subtypes of inflammatory myopathies (IM) and to provide insight into the pathogenesis of inclusion body myositis (IBM), polymyositis, and dermatomyositis. METHODS: Using Affymetrix GeneChip microarrays, the authors measured the simultaneous expression of approximately 10,000 genes in muscle specimens from 45 patients in four major disease categories (dystrophy, congenital myopathy, inflammatory myopathy, and normal). The authors separately analyzed gene expression in 14 patients limited to the three major subtypes of IM. Bioinformatics techniques were used to classify specimens with similar expression profiles based on global patterns of gene expression and to identify genes with significant differential gene expression compared with normal. RESULTS: Ten of 11 patients with IM, all normals and nemaline myopathies, and 10 of 12 patients with Duchenne muscular dystrophy were correctly classified by this approach. The various subtypes of inflammatory myopathies have distinct gene expression signatures. Specific sets of immune-related genes allow for molecular classification of patients with IBM, polymyositis, and dermatomyositis. Analysis of differential gene expression identifies as relevant to disease pathogenesis previously reported cytokines, major histocompatibility complex class I and II molecules, granzymes, and adhesion molecules, as well as newly identified members of these categories. Increased expression of actin cytoskeleton genes is also identified. CONCLUSIONS: The molecular profiles of muscle tissue in patients with inflammatory myopathies are distinct and represent molecular signatures from which diagnostic insight may follow. Large numbers of differentially expressed genes are rapidly identified.

We analyse 37 RXTE observations of the type 2 Seyfert galaxy Mrk 348 obtained over a period of 14 months. We confirm the spectral variability previously reported by Smith, Georgantopoulos & Warwick, in the sense that the column density decreases by a factor of ~3 as the count rate increases. Column density variations could possibly originate either from the random drift of clouds within the absorption screen, or from photoionization processes. Our modelling of the observed variations implies that the first scenario is more likely. These clouds should lie within a distance of >2 light-years from the source, having a diameter of a few light-days and a density of >107 cm-3 , hence probably residing outside the broad-line region.

The morphotectonic structure of the North Aegean Basin is studied on the basis of a new detailed swath bathymetric survey. The resulting bathymetric map is presented in reduction with 20-m isobaths. The slope analysis gives an accurate scheme of the geometry of the basin and distinction of several sub-basins (approximately 20). The overall basin geometry is a rectangular tetrahedron shaped by the major slope discontinuity separating the continental platform from the continental slope. The area distribution with depth shows a maximum at depths between 300 and 450 m along the sub-horizontal edge of the continental platform and at depths between 1000 and 1200 m at the basinal areas of the sub-basins. The separation of the western part of the North Aegean Basin from the eastern part (Saros Bay) is very clear in the area between Limnos and Thasos, with a maximum depth of 490 m. The 3.2% of the basin area is characterized by slope values >20%, which correspond to active fault zones. Their trend is NE-SW (N46o) and NW-SE (N136o). Some secondary E-W faults are also present within the basin with morphological expression only on the orientation of slopes <1%, reflecting deformation of the flat-lying deep parts of the basin’s interior. The overall geometry and inferred kinematics of the basin show an increase of both the vertical and horizontal components of the movement at the SW corner of the basin, where an opening of 40 km and a subsidence of 1600 m are contrasted to an opening of 20 km and a subsidence of 1000 m at the NE margin. The GPS data of the area showing an opening of 30 mm/yr are compatible with the above cumulative deformation for a neotectonic period of 4-5 Ma.

Objective: To evaluate postpartum MCH changes in the early postpartum period, and to examine whether neonatal MCA is related to that in maternal serum (MS) or milk. Study design: MCA was measured by EIA on the second and fifth postpartum day in serum and BM from 30 lactating women and their single term neonates. Sera from 20 healthy women (controls), were also analyzed. Results: All neonatal antigen concentrations were below the cut-off level for MCA (11ng/ml). MS MCA was significantly increased compared with that in controls (P<0.00001), while antigen values in BM were highly elevated (P<0.00001), with a significant increase (P<0.0003) from the second to the fifth postpartum day. A strong correlation was found between the second and fifth day postpartum samples in MS, neonatal serum and BM MCA concentrations (rs=0.94, P<0.00001; rs=0.75, P<0.00001 and rs=0.69, P<0.0001, respectively). A significant correlation was also found in MCA values on the fifth postpartum day between neonatal serum and BM (rs=0.54, P<0.02). Conclusions: From these findings one may speculate on some ripening process in milk production and a possible transition of MCA from the neonatal gastro-intestinal tract into circulation. © 2002 Elsevier Science Ireland Ltd. All rights reserved.

Purpose. To explore the quantitative structure pharmacokinetic relationships of the disposition parameters: clearance (CL), apparent volume of drug distribution (V-ap), fractal clearance (CLf), and fractal volume (v(f)) for 272 structurally unrelated drugs used in therapeutics. Methods. Literature data were used for CL and V-ap whereas CLf and v(f) were estimated as described previously (Pharm. Res. 18, 1056, 2001 and 19, 697, 2002). A variety of molecular descriptors expressing lipophilicity, ionization, molecular size and hydrogen bonding capacity were estimated using computer packages. The data were analyzed using multivariate statistics. For each disposition parameter (CL, V-ap, CLf, v(f)) PCA (principal component analysis) and PLS (projection to latent structures) were applied to the total set of data as well as to subsets of data. Results. Drugs were divided into two classes (I and II) according to their v(f) /V-ap ratio. Class I comprises 131 drugs with v(f) /V-ap >1, whereas class II 141 drugs with v(f) /V-ap < 1. After initial PLS analysis, class I was subdivided in subclusters I-a (30 drugs) and I-b (101 drugs). It was found that Ia included mostly acidic drugs with high protein binding, whereas class II comprises mainly basic, lipophilic compounds. No correlation was found between CL, V-ap, CLf and the used descriptors. Adequate PLS models were derived for v(f) considering subclusters I-a, I-b and class II separately. The low v(f) values of class I-a drugs were affected negatively from molecular size descriptors and non- polar surface area. For class I-b drugs with intermediate v(f) values, apparent lipophilicity contributed positively, although molecular size descriptors and polarity were inhibitory factors. The high v(f) values of class II drugs were positively dependent on intrinsic lipophilicity and increased basicity, whereas polarity entered with negative contribution. Conclusions. The parameters V-ap, CL, and CLf fail to reflect the physicochemical properties of drugs. The transformation of V-ap values to v(f) is the underlying cause for the valid models for v(f). These models allow a global consideration of molecular properties (lipophilicity, ionization, molecular size, polar surface area) which govern the distribution of drugs in the human body. The present study provides additional evidence for the physiologically sound concept of v(f)

On 7 September 1999 at 11:56 GMT a destructive earthquake (Mw = 6.0) occurred close to Athens (Greece). The rupture process is examined using data from the Cornet local permanent network, as well as teleseismic recordings. Data recorded by a temporary seismological network were analyzed to study the aftershock sequence. The mainshock was relocated at 38.105°N, 23.565°E, about 20 km northwest of Athens. Four foreshocks were also relocated close to the mainshock. The modeling of teleseismic P and SH waves provides a well-constrained focal mechanism of the mainshock (strike = 105°, dip = 55° and rake = -80°) at a depth of 8 km and a seismic moment M0 = 1.01025 dyn·cm. The obtained fault plane solution represents normal faulting indicating an almost north-south extension. More than 3500 aftershocks were located, 1813 of which present RMS < 0.1 s and ERH, ERZ < 1.0 km. Two main clusters were distinguished, while the depth distribution is concentrated between 2 and 11 km. Over 1000 fault plane solutions of aftershocks were constrained, the majority of which also correspond to N–S extension. No surface breaks were observed but the fault plane solution of the mainshock is in agreement with the tectonics of the area and with the focal mechanisms obtained by aftershocks. The hypocenter of the mainshock is located on the deep western edge of the fault plane. The relocated epicenter coincides with the fringe that represents the highest deformation observed on the differential interferometric image. The calculated source duration is 5 sec, while the estimated dimensions of the fault are 15 km length and 10 km width. The source process is characterized by unilateral eastward rupture propagation, towards the city of Athens. An evident stop phase observed in the recordings of the Cornet local stations is interpreted as a barrier caused by the Aegaleo Mountain.

Arbitrary null-subject constructions are a common property of null- subject languages. Their semantic and syntactic properties have been studied in the Principles and Parameters framework and have been attributed to the assignment of an arbitrary index at the Logical Form as a consequence of their licensing by the interaction of theta and case theory at the level of Deep Structure. In this paper we review the semantic and syntactic properties of arbitrary null-subjects in Greek and we try to analyse these properties in terms of the more general licensing principles of null-subjects and indefiniteness.

Nursing Information System (NIS) is a part of a health care information system that deals with nursing aspects, particularly the maintenance of the nursing record. The several objectives that a Nursing Information system should meet in order to succeed its aims, cover the users' needs and operate properly are described. The functions of such systems, which combine with the basic tasks of the nursing care process, are examined. As Nursing Information System is part of the health care and hospital information system, the different strategies and approaches for designing and developing Hospital Information Systems followed from the decade of 1970 until the recent decade of 1990, are presented. The three main approaches followed were the "centralized approach", the "departmental approach", and the "distributed approach". The advantages and drawbacks of each different approach are examined. For the implementation or upgrade of Nursing Information System a NIS committee comprised by different health care professionals, is necessary to be formed. The implementation and upgrade of a Nursing Information System follows some specific phases. These steps, include planning phase, analysis phase, design phase, development phase, implementation phase, and upgrade phase. A paragraph at the end of this chapter summarizes the future trends of Nursing Information Systems.

After the unexpected superoutburst of WZ Sge on July 23, 2001, the light curve was dominated by the orbital variability with a switch to dominating superhumps after August 5. The time series analysis of our data has shown, that the superhumps have started at the early stage of the superoutburst.

A series of 99mTcO[SN(R)S][S] complexes carrying the 1-(2-methoxyphenyl)piperazine moiety on the tridentate ligand [SN(R)S] was synthesized. For structural characterization and for in vitro binding assays the analogous oxorhenium complexes were prepared. As demonstrated by appropriate competition binding tests in rat hippocampal preparations, all oxorhenium analogues showed affinity for the 5-HT(1A) receptor binding sites with IC(50) values at the nanomolar range (IC(50)= 5.8-103 nM). All 99mTcO[SN(R)S]/[S] complexes showed significant brain uptake in rats at 2 min p.i. (0.24-1.31% ID). However, a clear correlation between distribution of radioactivity in the brain and distribution of 5-HT(1A) receptors could not be established.

Among the most important aspects of the atmospheric pollution problem are the anthropogenic impacts on the stratospheric ozone layer, the related trends of the total ozone content drop and the solar ultraviolet radiation enhancement at the Earth’s surface level. During September 2002, the ozone hole over the Antarctic was much smaller than in the previous six years. It has split into two separate holes, due to the appearance of sudden stratospheric warming that has never been observed before in the southern hemisphere.The analysis of this unprecedented event is attempted, regarding both the meteorological and photochemical aspects, in terms of the unusual thermal field patterns and the induced polar vortex disturbances.

The 88th Canon of  the Synod in Tullo (Trullo 88), punishing the crime of importing animal at church, remained for centuries at the backstage of canonical research, undermined, forgotten and misunderstood. This survey, brings the canon to the forefront, and spotlights its content as a most singnificant disclosure of the structure and theory of Church Criminal Law. The book is a manual of the General Part of Church Criminal Law: The action, the hypostasis of the crime, reasons of  lifting the unjust, external terms of criminality, criminal liabilty  are investigated in this "byzantine" canon. Last but not least:  a) we analyse how  the General Principle of  placing the Rights  Human Life and Health at the top of the Pyramid of Canonical Protection is provided by the Trullo 88 and is introduced to the whole Canon Law, b) we notice  the fact that the Canon introduces the Evangelic speech about the Sabbath into the field of Church Law, with serious consequences in the "philosophy" (=theology) of Orthodox Canon Law.

Purpose: We conducted this randomized study comparing the activity and toxicity of paclitaxel and gemcitabine (PG) and paclitaxel and carboplatin (PC) combinations for the treatment of advanced non-small-cell lung cancer (NSCLC). Patients and Methods: Chemotherapy-naive patients were randomized to paclitaxel 200 mg/m2 on day 1 plus either carboplatin at an area under the concentration-time curve of 6 on day 1 (group A) or gemcitabine 1,000 mg/m2 on days 1 and 8 (group B) every 3 weeks. A retrospective cost analysis was conducted using Student's t test to compare independent samples between groups. Results: A total of 509 patients (group A, 252 patients; group B, 257 patients) were enrolled; all characteristics were well balanced. The median survival time was 10.4 months (95% confidence interval [CI], 8.8 to 12 months) for group A and 9.8 months (95% CI, 8.0 to 11.7 months) for group B (P = .32). Respective 1-year survival rates were 41.7% and 41.4%. The response rate for group A was 28.0% (2% complete response [CR], 26% partial response [PR] [95% CI, 22% to 34%]), and the response rate for group B was 35.0% (5% CR, 30% PR) [95% CI, 29% to 41%]) (P = .12). Toxicity was mild. Grades 3/4 neutropenia, thrombocytopenia, and anemia for groups A and B were seen in 15% and 15%, 2% and 1%, and 5% and 2%, respectively. The mean total cost (outpatient clinic visits plus chemotherapy drug fee) for group A (€ 7,612.64) versus group B (€ 7,484.77) was not statistically significant (P < .66). Conclusion: The PG combination is as equally active and well tolerated as the PC combination in patients with advanced NSCLC. © 2002 by American Society of Clinical Oncology.

We conducted a phase III study in patients with advanced colorectal carcinoma (ACC). The total number of patients randomized from October 1993 until July 1998 was 192, whereas therapy was started on 179 and 158 (82.3%) have been evaluable. The treatment schedules consisted of weekly bolus administration for 6 weeks of 5-fluorouracil (5-FU), 600 mg/m2 (arm I) versus 5-FU (500 mg/m2) intravenous bolus and interferon-α, 5 MU subcutaneously, three times a week (arm II) versus leucovorin 200 mg/m2 in 2-hour infusion and 5-FU 500 mg/m2 intravenous bolus at the midtime of leucovorin infusion (arm III) followed by a 2-week rest period. Treatment was continued for six cycles or until progression. This study failed to show any superiority of the modulated 5-FU versus single administration of 5-FU. There were no significant differences between the three arms in the overall response rate (10.3% versus 11.3% versus 12.9%, p = 0.95), the time to tumor progression (median, 3.9 versus 3.8 versus 6.0 months, p = 0.59), or survival duration (median, 14.7 versus 12.4 versus 16.3 months, p = 0.71). The incidence of severe (grades III and IV) toxicity was significantly higher in patients in arm II and III (24.5% and 18.6%) versus arm I (6.0%) (p = 0.01). Because modulated 5-FU failed to show superiority versus 5-FU, new agents and new strategies are needed for the treatment of advanced colorectal carcinoma.

Three iron oxide pigments: Hematite, goethite and magnetite, have been synthesized from the copperas by-product produced as a waste material in large quantities in the titanium dioxide plant in Chemical Works "Police," Poland. These pigments have been characterized by X-ray diffractometry and X-ray fluorescence spectroscopy and it has been found that they are mono-phase systems with only a small addition of other spurious phases. The electrical resistivity measurements reveals that the ion oxide samples are semiconductor materials. Conductivity of magnetite at room temperature is over six orders of magnitude greater than that of the other two materials. Photoacoustic (PA) spectra of hematite and goethite in the visual region of the electromagnetic radiation shows a single intense absorption peak centred at 558 and 480nm, respectively, while for the magnetite a continuous spectrum of increasing amplitude with increasing wavelength of the measurement is obtained. EPR spectra for the iron(III) complexes have been registered at room temperature which indicate hematite and goethite have only one similar EPR line centred at g ∼ 2 with different linewidths, while magnetite has two very intense overlapping and broad EPR lines centred at low and high magnetic resonance fields. Additional EPR line of Mn2+ ions has been also recorded for the hematite sample. Application of these pigments is discussed in terms of economic and environmental advantages. © 2002 Elsevier Science Ltd. All rights reserved.

OBJECTIVES: We sought to investigate the effects of physical training on circulating proinflammatory cytokines and the soluble apoptosis mediators Fas (sFas) and Fas ligand (sFasL) in patients with chronic heart failure (CHF). BACKGROUND: Recent investigations have shown an overexpression of circulating proinflammatory cytokines and soluble apoptosis mediators in patients with CHF, which may be related to their exercise intolerance and clinical deterioration. METHODS: Plasma levels of tumor necrosis factor-alpha (TNF-alpha), soluble TNF receptors I and II (sTNF-RI and sTNF-RII, respectively), interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6R), sFas and sFasL were measured in 24 patients with stable CHF (New York Heart Association functional class II/III; left ventricular ejection fraction 23.2 +/- 1.3%) and in 20 normal control subjects before and after a 12-week program of physical training in a randomized, crossover design. Functional status of patients with CHF was evaluated by using a cardiorespiratory exercise test to measure peak oxygen consumption (VO2max). RESULTS: Physical training produced a significant reduction in plasma levels of TNF-alpha (7.5 +/- 1.0 pg/ml vs. 4.6 +/- 0.7 pg/ml, p < 0.001), sTNF-RI (3.3 +/- 0.2 ng/ml vs. 2.7 +/- 0.2 ng/ml, p < 0.005), sTNF-RII (2.6 +/- 0.2 ng/ml vs. 2.3 +/- 0.2 ng/ml, p = 0.06), IL-6 (8.3 +/- 1.2 pg/ml vs. 5.9 +/- 0.8 pg/ml, p < 0.005), sIL-6R (34.0 +/- 3.0 ng/ml vs. 29.2 +/- 3.0 ng/ml, p < 0.01), sFas (5.5 +/- 0.7 ng/ml vs. 4.5 +/- 0.8 ng/ml, p = 0.05) and sFasL (34.9 +/- 5.0 pg/ml vs. 25.2 +/- 4.0 pg/ml, p < 0.05), as well as a significant increase in VO2max (16.3 +/- 0.7 ml/kg per min vs. 18.7 +/- 0.8 ml/kg per min, p < 0.001). Good correlations were found between a training-induced increase in VO2max and a training-induced reduction in levels of the proinflammatory cytokine TNF-alpha (r = -0.54, p < 0.01) and the apoptosis inducer sFasL (r = -0.57, p < 0.005) in patients with CHF. In contrast, no significant difference in circulating cytokines and apoptotic markers was found with physical training in normal subjects. CONCLUSIONS: Physical training reduces plasma levels of proinflammatory cytokines and the sFas/sFasL system in patients with CHF. These immunomodulatory effects may be related to the training-induced improvement in functional status of patients with CHF

The development of new hydrogen selective neutral carriers based on 3-hydroxypicolinic acid derivatives, and its application to pH selective liquid membrane ISE based on these compounds is described. The optimization of the sensor has been based on the use of different plasticizers, additives, and mole ratios of the picolinate derivatives. Based on these results it is shown that the membrane composition can be adjusted for the measurement of pH at very low pH values (down to pH -0.5) and up to at least pH 10. The ability of the presented carriers to measure hydrogen activities up to 3N gives new directions in the use of these sensors for a variety of critical applications.

We report on the second peak line H-sp and the possible phases of vortex matter near T-c for a detwinned underdoped YBa2Cu3O7-delta single crystal. Our local ac and dc permeability measurements revealed that the second peak line H-sp does not terminate either at the critical temperature or on the irreversibility line H-irr. Pronounced hysteretic behavior is observed in the regime below the second peak line H-sp. Below (above) a characteristic field the end point of the second peak differs from (coincides with) the irreversibility point, H(end point)not equalH(irr) (H(end point)equivalent toH(irr)). A possible reentrance of a dynamically ordered solid phase in the high-temperature regime near the irreversibility line is discussed.

Several famous athletes have been affected by ALS, and some epidemiologic studies have indicated that vigorous physical activity (heavy labor or athletics) is a risk factor for the disease. In a case-control study of 279 patients with motor neuron diseases and 152 with other neurologic diseases, the authors found that subjects with motor neuron diseases were more likely than controls to report they had always been slim or they had been varsity athletes. For slimness, the odds ratio (OR) was 2.21; 95% CI, 1.40 to 3.47. For varsity athletics, the OR was 1.70; CI, 1.04 to 2.76.

Water samples for coccolithophorid analysis were collected in August 2001, from 8 stations along a transect in the gulf of Korthi (Andros Island, Aegean sea). Samples were collected from 0-120m water-depth. Holococcolithophorid absolute abundances usually range between 7.29x103 and 0.06x103 cells/l. The derived distribution patterns indicate that holococcolithophorids bearing holococcoliths with convex cover above the tube, may constitute a significant part of the summer flora in the uppermost photic zone of the coastal waters of Andros island, showing affinities to shallower environments. 

Water samples for coccolithophorid analysis were collected in August 2001, from 8 stations along a transect in the gulf of Korthi (Andros Island, Aegean sea). Samples were collected from 0-120m water-depth. Holococcolithophorid absolute abundances usually range between 7.29x103 and 0.06x103 cells/l. The derived distribution patterns indicate that holococcolithophorids bearing holococcoliths with convex cover above the tube, may constitute a significant part of the summer flora in the uppermost photic zone of the coastal waters of Andros island, showing affinities to shallower environments. 

Micro-Raman measurements under hydrostatic pressures up to 6GPa have been carried out on high-quality La2-xSrxCuO4 polycrystalline compounds with Sr concentration up to x=0.45. The zz scattering polarization has been investigated, where two strong modes due to La/Sr and the apex oxygen, and (in the low Sr concentrations) the soft mode at ≃100cm-1 are observed. The frequency of the strong modes increases almost linearly with pressure for the Sr concentrations studied. Modifications in the increment rate dω/dp and the phonon width have been detected depending on the amount of doping. For x=0.45 a considerable increase in the width of both strong phonons with pressure was found, which must reflect a separation into phases, since this concentration is close to the solubility limit. The relative intensity of the strong phonons was investigated in connection with its correlation to the transition temperature.

The case is described of a 36 year-old man who presented with progressive proximal muscle weakness and weight loss. His serum creatine phosphokinase (CPK) levels were markedly elevated. The muscle biopsy showed lipid storage myopathy. The muscle carnitine concentration was extremely low (5.6% of normal levels), establishing the diagnosis of myopathic carnitine deficiency. The disorder was considered as primary because there were no indications of any other identifiable condition which could result in a secondary carnitine deficiency. The patient was treated with oral L-carnitine (2 g per day) and showed rapid improvement. Primary myopathic carnitine deficiency is a curable disorder and therefore it should always be considered as a potential diagnosis in cases of myopathy in young adults.

The treatment of patients with recurrent low-grade lymphoma with the combination of fludarabine, mitoxantrone and dexamethasone has been associated with significant activity but has also caused frequent infectious complications. We designed a phase II study for previously untreated patients with the combination of fludarabine and mitoxantrone but without steroids. Our aim was to assess the activity of this combination as primary treatment for low-grade lymphoma and to avoid the additional immunosuppression induced by dexamethasone. Twenty seven patients with low-grade lymphoma received fludarabine 25 mg/m2/day IV on days 1-3 and mitoxantrone 10 mg/m2 IV on day 1. The treatment was repeated every 28 days for a maximum of six cycles. Twenty patients (74%) achieved an objective response including 12(44%) complete and 8(30%) partial responses. The main toxicity was grade III or IV neutropenia, which occurred in 40% of patients but there were no severe opportunistic infections. The median time to progression for all patients was 32 months. With a median follow-up of 33.4 months, six patients have died and the probability of survival at 3 years is 75%. We conclude that the fludarabine and mitoxantrone regimen is safe and effective for newly diagnosed patients with low-grade lymphoma who require treatment. Prospective randomized trials are needed in order to assess the impact of this treatment on patients' survival.

We consider the problem of predicting a risk index of an event on the base of several predictors. The specificity of the problem lies in the fact, that there are no training data; instead we have a set of logical rules describing in a fuzzy way several classes of the risk (’very low’, ’low’, ’medium’, ’high’ and ’very high’ risk). We present several problems and doubts we had met when trying to construct a predictor. After considering several alternatives we stated that a simple neural network architecture (with one perceptron) calculating logistic regression has given the best agreement with expert opinion. Thus,based on the rules, we are able to mimic the expert opinion by a neural network model.

BACKGROUND. Adverse effects of paclitaxel and carboplatin have been well described; however, pulmonary toxicity after patients receive this regimen has not been investigated extensively. METHODS. To clarify this issue, 33 consecutive patients who were treated with paclitaxel and carboplatin underwent prospective evaluation of respiratory function, which included pulmonary symptoms, pulmonary function tests (PFTs), arterial blood gas levels, and radiographic studies. Assessment was performed before and after completion of chemotherapy in all patients. Patients with substantial declines in PFTs, defined as a decline ≥ 20 percent in forced expiratory volume in 1 second (FEV1), total lung capacity (TLC), or diffusion capacity for carbon monoxide (DLCO), were reassessed 5 months later. RESULTS. After chemotherapy, there were no significant changes in forced vital capacity (FVC; 111% ± 21% of the predicted value before chemotherapy vs. 111 ± 20% of the predicted value after chemotherapy), FEV1 (108% ± 24% of the predicted value before chemotherapy vs. 107% ± 22% of the predicted value after chemotherapy), FEV1/FVC ratio (79% ± 8% before chemotherapy vs. 78% ± 6% after chemotherapy), alveolar volume (VA; 95% ± 14% of the predicted value before chemotherapy vs. 96% ± 14% of the predicted value after chemotherapy), or TLC (96% ± 14% of the predicted value before chemotherapy vs. 97% ± 13% of the predicted value after chemotherapy). In contrast, there was a significant decline in DLCO (101% ± 20% of the predicted value before chemotherapy vs. 96 ± 21% of the predicted value after chemotherapy; P < 0.05). Arterial blood gas levels did not change after treatment. No patient had decreased FEV1 or TLC levels by ≥ 20%, whereas 4 of 33 patients (12%) exhibited a substantial decline (≥ 20%) in DLCO that persisted 5 months after treatment (DLCO at baseline, immediately after chemotherapy, and 5 months after the completion of chemotherapy, respectively: 99% ± 36% of the predicted value vs. 75% ± 28% of the predicted value vs. 74% ± 31% of the predicted value; P < 0.05). None of the 33 patients developed respiratory symptoms or had radiologic signs suggestive of lung toxicity. Among the various risk factors examined, baseline DLCO and FEV1 levels were associated with changes in DLCO post-treatment. CONCLUSIONS. This prospective analysis showed that the combination of paclitaxel with carboplatin induced an isolated decrease in DLCO level in the absence of clinical or radiologic evidence of toxicity. Further studies are needed to clarify whether this reduction in DLCO is predictive of subsequent pulmonary impairment. © 2002 American Cancer Society.

1. Introduction 2. Superlumminal Motion 3. Doppler Boosting 4. Photon-Photon Pair Binding 5. Synchrotron Radiation 6. Inverse Compton Scattering 6.1. Thomson Scattering 6.2. Klein-Nishina Limit 7. Synchro Self-Compton Radiation 8. Continuity Equation 9. Coda References

We analyse the fine structure of the type IV radio burst, during the main phase of the 14th July 2000 major event recorded by the radiospectrograph ARTEMIS-IV, in the 110-650 MHz (10 Hz sampling rate) and the 270-450 MHz (100 Hz rate) range. In this report we focus on variations in frequency drift rate and repetition rate of fibers bursts. A pronounced asymmetry between the number of bursts with positive and negative frequency drift is noted at certain time periods. These variations follow closely the evolution of the magnetic structure associated with the major solar event and the onset of the corresponding CME.

Rhinoviruses are the major cause of common colds and of asthma exacerbations. Intercellular adhesion molecule-1 (ICAM-1) has a central role in airway inflammation and is the receptor for 90% of rhinoviruses. Rhinovirus infection of airway epithelium induces ICAM-1. Because redox state is directly implicated in inflammatory responses via molecular signaling mechanisms, here we studied the effects of reducing agents on rhinovirus-induced ICAM-1 expression, mRNA up-regulation, promoter activation, and nuclear factor activation. To investigate the effects of rhinovirus infection on the intracellular redox balance, we also studied whether rhinovirus infection triggers the production of reactive oxygen species. We found that reduced (GSH) but not oxidized (GSSG) glutathione (1-100 microM) inhibited in a dose-dependent manner rhinovirus-induced ICAM-1 up-regulation and mRNA induction in primary bronchial and A549 respiratory epithelial cells. GSH but not GSSG also inhibited rhinovirus-induced ICAM-1 promoter activation and rhinovirus-induced NF-kB activation. In parallel, we found that rhinovirus infection induced a rapid increase of intracellular superoxide anion that was maximal at the time of NF-kB activation. This oxidant generation was completely inhibited by GSH. We conclude that redox-mediated intracellular pathways represent an important target for the therapeutic control of rhinovirus-induced diseases.

The large-scale dynamical processes associated with an exceptionally dry and warm autumn during 1993 in Greece were studied. On the regional scale, it was found that low-frequency eddies prevailed over Europe in the form of a block with large-scale descending motion persisting throughout the whole troposphere. Moreover, the subtropical jet was unusually positioned much farther north over the Balkan peninsula and oscillated between this position and one over the central mainland of Greece where it interacted with the southern part of the polar front jet. On the global scale, it was found that this type of atmospheric circulation over Europe was closely related with a region of latent heat release in convective clouds over the tropics between the longitudes 100° and 120°E, and the formation of a steady divergence system at 150 hPa over the same region, strongly affecting the global rotational flow. © 2002 Elsevier Science Ltd. All rights reserved.

Andros is the 2nd biggest island in Cyclades. Its morphology is intense and derives from the lithological and tectonical characteristics of the island. In this paper we studied Andro’s island environmental characteristics using Remote Sensing and GIS techniques. A GIS database was developed including all the corresponding geographical, geological, geomorphological and environmental characteristics. Moreover, an environmental map was developed at a 1:50.000 scale that elaborates all the above data. Remote Sensing techniques were also used in combination to the traditional cartographical methods, in order to locate with maximum accuracy all these data and input them in the GIS.

In response to the Israeli-Turkish strategic partnership of the 1990s Greece was driven closer than ever before to Israel. By the end of the 1990s it was clear that Athens had reached a turning point in its policy towards Israel. The PASOK government wished to maintain Greece's traditionally good relations with the Arabs. Nevertheless, it was ready to risk upsetting them in the pursuit of a good relationship with Israel. The promotion of relations with Jerusalem (underdeveloped for over 40 years), was understood to serve national policy goals. It was viewed as part of Greece's strategy towards Turkey (Greece's perennial adversary), as well as of its policy of full alignment with the US and its EU partners. Developments in the regional environment and the ability of the Greek government to respond to opportunities will determine whether Greek-Israeli relations could grow in substance.

Rhinovirus (RV) infection is the commonest trigger of acute asthma exacerbations; however, the immune response to these viruses and any potential implications in the mechanisms leading to asthma exacerbations are not well understood.|To assess the effects of in vitro RV infection on the phenotype and expression of costimulatory molecules on peripheral blood mononuclear cells (PBMC) from normal and atopic asthmatic subjects, as a model for RV antigen presentation.|PBMC from seven normal and seven asthmatic subjects were exposed to one infectious unit/cell of RV16 for 48 h. Surface expression of CD25, CD28, CD40, CD54, CD80, CD86 and CTLA-4 was evaluated on CD3, CD4, CD8, CD14 and CD19 PBMC subpopulations by three-colour flow cytometry.|No changes in the percentage of CD3, CD4, CD8 or CD19 were observed. CD14 was significantly reduced by the infection and this was more pronounced in normal subjects. On Th cells CTLA-4 was increased after RV infection only in the asthmatic group. Levels of CD80 and CD86 in the control cultures were lower in the asthmatic group. RV infection induced a significant increase of CD80 on monocytes and of CD86 on B cells, which occurred in both groups but were less marked in atopic asthmatic subjects.|Exposure of PBMC to RV is able to activate the antigen presentation machinery. Differences between normal and atopic asthmatic individuals are compatible with the hypothesis that an aberrant immune response to RV may be involved in the development of acute exacerbations in atopic asthmatic subjects.

OBJECTIVE: The etiology of most cases of myelodysplastic syndromes (MDS) has not been elucidated. We have undertaken an investigation in Greece to determine the risk profile of adult de-novo MDS. METHODS: A case-control investigation was conducted in a large Veterans' hospital over a five-year period, covering 84 MDS cases and 84 age- and gender-matched controls with minor non-neoplastic non-infectious conditions from the same study base. Cases and controls reported to the medically trained principal investigator lifestyle characteristics and medical histories, with emphasis on autoimmune disorders and allergic conditions. RESULTS: Alcohol intake and tobacco smoking jointly increased significantly the risk of MDS (odd ratio contrasting ever smokers and regular drinkers of at least one glass per day to never smokers and drinkers of less than one glass per day: 9.54. 95% CI 3.52-25.82) whereas each of these factors alone had limited effect. There was also evidence that autoimmune conditions, but not allergic disorders, were positively associated with MDS risk, irrespective of their occurrence during the recent (less than ten years) or the remote (more than ten years) past (OR 3.34, 95% CI 1.15-9.74; OR 3.50, 95% CI 1.19-10.26, respectively). CONCLUSION: We found evidence that both exogenous and endogenous factors may play a role in the etiology of the so-called "de novo" myelodysplastic syndromes, but these findings need further confirmation.

We consider the effect of different approximations to the dielectric function of a silver sphere on the absorption of light by two-dimensional and three-dimensional periodic and non-periodic arrays of non-overlapping silver spheres in a host dielectric medium. We also present some results on the band structure and the absorption coefficient of light by photonic crystals consisting of non-overlapping silver-coated spheres in a dielectric medium.

Using the multiple-scattering formalism we developed in a previous work, and extended here, we analyze available experimental data on the transmission of longitudinal waves in the system: water-slab of polyester-water, the slab of polyester having a plane of glass or lead or steel spheres in the middle. The theoretical results reproduce accurately the measured spectra and provide a transparent physical picture of the underlying processes. In particular, the dips in the observed spectra are attributed to multiple wave scattering between the spheres, and are related to hybridization-induced gaps in the frequency band structure of the longitudinal elastic modes of a corresponding infinite crystal.

Immunomediators seem to have a central role in the immune system of both human milk and newborn infants. CD31/PECAM-1 is an adhesion molecule, member of Ig gene superfamily, mediating cell-cell adhesion in both homophilic and heterophilic ways. Levels of the soluble form of PECAM-1 (sPECAM-1) were evaluated on the 2nd and 5th day postpartum in breast milk and serum paired samples from 20 lactating women as well as in time-matched serum from their single, term, healthy neonates. Concentrations of sPECAM-1 in breast milk (median, range) on both the 2nd (2.05 ng/ml, 0.0-7.2) and 5th day postpartum (0.89 ng/ml, 0.0-3.6) were about 10 and 20 times lower than those (mean ± SD) in controls (healthy adults) (19.83 ± 5.17, p < 7 × 10-8), showing a significant fall from the 2nd to the 5th day postpartum (p < 0.0005). Maternal serum sPECAM-1 values (mean ± SD) were significantly lower on the 2nd day postpartum (14.21 ± 5.15 ng/ml) than those in controls (p < 0.002), but reached control values on the 5th day postpartum after a significant rise (p < 0.0075). Neonatal serum sPECAM-1 values with no significant difference between the 2nd (14.4 ± 4.11 ng/ml) and 5th day of life (14.54 ± 4.99 ng/ml) were significantly lower than those in controls (p < 0.002). Values of sPECAM-1 in milk and sera of lactating mothers and their neonates on the 2nd day postpartum depended on the mode of delivery, being significantly lower after caesarean section (p < 0.034, p < 0.0075 and p < 0.035, respectively). In conclusion, our findings in the early postpartum period demonstrate that: (a) sPECAM-1 is present in human milk in low and decreasing concentrations; (b) the shedding of sPECAM-1 is an established component of the neonatal immune system from birth, though in lower concentrations than in adults, possibly reflecting its immaturity; and (c) the mode of delivery has a significant effect on sPECAM-1 values in milk and sera of lactating mothers and their neonates; the lower values after caesarean section may reveal a deranged endothelial homeostasis. © 2002 Elsevier Science Ireland Ltd. All rights reserved.

Solitary bone and extramedullary plasmacytomas are rare plasma cell proliferative disorders. Their diagnosis is based on histologic confirmation of monoclonal plasma cell infiltration of a single disease site and on the exclusion of systemic myeloma. For both entities, the treatment of choice is localized radiotherapy. With modern radiotherapy and with a total dose of at least 4000 cGy, the risk for local recurrence is less than 5%. There is no role for systemic chemotherapy in the management of these disorders. Approximately 30% of patients with solitary bone plasmacytoma (SBP) remain disease-free for several years; some of these patients may be cured. Patients with the best prognosis are those in whom the monoclonal protein disappears by 1 year after radiotherapy. The prognosis of patients with solitary extramedullary plasmacytoma (SEP) appears to be better than for patients with SBP because approximately 70% of patients with SEP remain disease-free at 10 years. With more sensitive staging procedures, the diagnosis of SBP and SEP may become less common, but the number of patients with prolonged stability and cure may increase.

The purpose of this chapter is to present a conceptual framework that applies to almost all statistical procedures discussed so far in this text. We also describe briefly, using a conceptual framework only, some of the more advanced techniques used in medicine.

Stomata of various sizes are produced on the primary root of Ceratonia siliqua L. Most are generated during embryogenesis, prior to seed desiccation. They can be detected on the dry embryo in a wide zone just above the root tip. Initially, large stomata are formed. These have the ability to induce divisions of their neighbouring cells, creating particular cell patterns around them. Later, small perigenous stomata are generated. As the root grows following seed germination, the stomatal zone overlaps with that of the root hairs. Although root stomata of C. siliqua undergo a structural differentiation that seems almost identical to that of the elliptical stomata formed on leaves, they are unable to move and remain permanently open. Polarizing microscopy of fully differentiated stomata and young stomata at the stage of stomatal pore formation revealed deposition of radial cellulose microfibril systems on their periclinal walls. However, these systems were less developed than those on leaf stomata, a feature that might he responsible for their inactivity. Besides, plastids of the root guard cells (GCs) do not differentiate into chloroplasts but function solely as amyloplasts. Root stomata have a short life span. During rapid and intense root growth, GCs cannot keep pace with the elongation of their neighbouring rhizodermal cells. They therefore split in their mid-region, transversely to the stoma axis. The two parts of the transversely torn stoma are dragged apart and a large opening is formed on the root surface, just above the substomatal cavity. The root stomata, together with these openings, may facilitate increased gaseous exchange during respiration and/or an increased transfer of some nutrients and water in the rapidly growing primary root. © 2002 Annals of Botany Company.

In this paper we study the coastal zone in the region of Acheloos’ river mouth and delta. In recent years, this region has been subjected to a series of environmental changes, primarily due to intense human activity concerning large hydroelectricdams. These dams created between 1960 and 1986 are responsible for important changes of the river’s flow. The purpose of this study is to record the changes that have occurred between those years and present time; to define and analyze their possible consequences on the coastal geomorphology of the region. For this reason we used topographical and geological maps (scale 1:50.000), aerial photos (scale 1:33.000) and finally satellite photos. A geographical database has been created in a GIS with environmental, geological, geomorphological and anthropogenic features of the studied area. All digital data were analyzed spatially and quantitative in order to describe the change of delta shape, size and finally the occupied land use. Finally different thematic maps were created showing the geomorphological and environmental changes during those years.

We propose that the internal energy of the gamma-ray burst (GRB) blast waves, thought to be stored in the form of relativistic protons comoving with the blast wave, is converted explosively (i.e., on light crossing timescales) into relativistic electrons of the same Lorentz factor, which are responsible for the production of observed prompt γ-ray emission of the burst. This conversion is the result of the combined effects of the reflection of photons produced within the flow by upstream located matter, their reinterception by the blast wave, and their eventual conversion into e+e- pairs in interactions with the relativistic protons of the blast wave (via the pγ-->pe+e- reaction). This entire procedure is contingent on two conditions on the relativistic protons: a kinematic one imposed by the threshold of the pγ-->pe+e- reaction and a dynamic one related to the column density of the postshock matter to the same process. This latter condition is in essence identical to that of the criticality of a nuclear pile, hence the terminology. It is argued that the properties of relativistic blast waves operating under these conditions are consistent with GRB phenomenology, including the recently found correlation between quiescence periods and subsequent flare fluence. Furthermore, it is shown that, when operating near threshold, the resulting GRB spectrum produces its peak luminosity at an energy (in the lab frame) E~=mec2, thereby providing an answer to this outstanding question of GRBs.

An efficient route for the synthesis of enantiopure unnatural α-amino acids and 2-amino alcohols was developed. The synthesis is based on the Wittig-type olefination of 3-benzyloxy-2-(tertbutoxycarbonylamino)propanal with various ylides.

An efficient synthesis of (S)-α-amino oleic acid was developed. The fully protected FA derivative was obtained in four steps starting from methyl (2S)-2-[bis(tert-butoxycar-bonyl)amino]-5-oxopentanoate. These steps are (i) olefination of the starting aldehyde with the appropriate phosphonate anion, (ii) hydrogenation of the double bonds, (iii) controlled reduction of ω-ethyl ester to an aldehyde in the presence of α-methyl ester, and (iv) a Wittig reaction of the latter aldehyde with the suitable ylide. Free α-amino oleic acid was prepared after deprotection of the amino group followed by saponification in a total yield of 24%. N-tert-Butoxycarbonyl-protected amino oleic acid and the corresponding amino alcohol were prepared in high yield. The structures of the products have been established by various spectroscopic techniques.

We present a systematic method for constructing two-dimensional magnetohydrodynamic equilibria with compressible flow in Cartesian geometry. This systematic method has already been developed in spherical geometry and applied in modelling solar and stellar winds and outflows (Vlahakis & Tsinganos \cite{Vlahakis98}) but is derived here in Cartesian geometry in the context of the solar atmosphere for the first time. Using the method we find several new classes of solutions, some of which generalise known solutions, including the Kippenhahn & Schlüter (\cite{Kippenhahn57}) and Hood & Anzer (\cite{Hood90}) solar prominence models and the Tsinganos et al. (\cite{Tsinganos93}) coronal loop model with flow, and some of which are completely new. Having developed the method in full and summarised the several classes of solutions, we explore in a some detail one of the classes to illustrate the general construction method. From one of the new classes of solutions we calculate two loop-like solutions, one of which is the first exact two-dimensional magnetohydrodynamic equilibrium with trans-Alfvénic flow.

We present a systematic method for constructing two-dimensional magnetohydrodynamic equilibria with compressible flow in Cartesian geometry. This systematic method has already been developed in spherical geometry and applied in modelling solar and stellar winds and outflows (Vlahakis & Tsinganos \cite{Vlahakis98}) but is derived here in Cartesian geometry in the context of the solar atmosphere for the first time. Using the method we find several new classes of solutions, some of which generalise known solutions, including the Kippenhahn & Schlüter (\cite{Kippenhahn57}) and Hood & Anzer (\cite{Hood90}) solar prominence models and the Tsinganos et al. (\cite{Tsinganos93}) coronal loop model with flow, and some of which are completely new. Having developed the method in full and summarised the several classes of solutions, we explore in a some detail one of the classes to illustrate the general construction method. From one of the new classes of solutions we calculate two loop-like solutions, one of which is the first exact two-dimensional magnetohydrodynamic equilibrium with trans-Alfvénic flow.

Objective: To study the effect of 17β-estradiol+norethisterone acetate and raloxifene on the endometrium and uterine volume in postmenopausal women. Methods: Patients were randomly assigned to 17β-estradiol 2 mg+norethisterone acetate 1mg (E2+NETA) daily (n=90) or raloxifene HCl 60 mg (Evista) daily (n=43). Transvaginal sonography was done at baseline and at 6, 12 and 18 months, and at 6 and 12 months in-patients treated with E2+NETA and EVISTA respectively. Patients were asked to record bleeding-spotting episodes. Whenever required patients were referred for hysteroscopy±biopsy of the endometrium. Results: Patients under E2+NETA had a higher bleeding-spotting incidence (48.6%) compared with EVISTA (7.7%). Endometrial thickness increased significantly under E2+NETA as compared with baseline; however, at end point thickness reverted to baseline values. Evista had a non-stimulatory effect on the endometrium. Changes in uterine volume were not statistically significant. Conclusions: Both treatment regimens provided comparable uterine safety. However, raloxifene exhibited a more favorable safety profile on the uterus as expressed in the bleeding-spotting incidence and the effect on endometrial thickness and uterine volume. Transvaginal sonography appears to be a dependable method for monitoring the effect of treatment on the uterus. © 2002 Elsevier Science Ireland Ltd. All rights reserved.

Introduction: During the last few years epirubicin (E) and mitoxantrone (M) (Novantrone) have been used in the treatment of non-Hodgkin's lymphoma (NHL), because of their favorable principal profile. In particular, M has less severe non-hematological toxicity. Patients and methods: A randomized multicenter phase III study was conducted in order to compare the efficacy and toxicity of CEOP and CNOP in intermediate- and high-grade NHL. CEOP (arm A) consisted of cyclophosphamide 1000 mg m-2, vincristine 2 mg, E 70 mg m-2 on day 1 and prednisone 60 mg on days 1-7. The CNOP regimen (arm B) was identical to CEOP except for replacement of E by M at a dose of 12 mg m-2. Randomization was stratified according to stages I-IV. From September 1993 to March 1999, 249 patients registered for the trial. Patient characteristics were equally distributed in the two arms, except for age and International Prognostic Index (IPI) groups. Results: There were no significant differences between the two groups in the rates of complete (CR) and partial response (PR). The overall response rate was 78% in arm A (57% CR, 21% PR) and 82% in arm B (60% CR, 22% PR). With a median follow-up time of 47.3 months, the median survival was not reached in arm A, while it was 39.5 months in arm B (P=0.09). Three-year survival rates were 62.5% for CEOP and 51.5% for CNOP. There was no significant difference regarding the time to progression between the two groups (29.7 vs. 18.5 months); furthermore the median duration of CRs was 71.6 and 49 months for CEOP and CNOP, respectively (P=0.07). The therapeutic efficacies of both regimens were equivalent among the four IPI groups. More alopecia was observed in arm A. WHO grade >2 neutropenia was more frequent in arm B. Supportive treatment with G-CSF was given to 22 and 24 patients, respectively. Conclusion: There were no significant differences in terms of overall response rates, overall survival and time to progression between CEOP and CNOP in the treatment of intermediate- and high-grade NHL. Patients with low or low intermediate IPI risk treated with either CEOP or CNOP showed significantly better survival, response rates and time to progression than those with high intermediate or high IPI risk. Therefore, new improved therapeutic approaches should be developed for the treatment of high IPI risk patients.

Purpose: Waldenström's macroglobulinemia (WM) is a low-grade lymphoplasmacytic lymphoma in which CD20 is usually expressed on tumor cells. There is evidence that patients with WM may benefit from treatment with the anti-CD20 monoclonal antibody rituximab. We performed a prospective phase II study to clearly define the activity of rituximab in patients with this disease. Patients and Methods: Twenty-seven patients with WM were treated with rituximab 375 mg/m2 intravenously (IV) for 4 weeks. Three months after completion of rituximab, patients without evidence of progressive disease received repeat 4-week courses of this agent. All patients were symptomatic, their median age was 72 years, and 15 patients were previously untreated. Results: Twelve patients (44%; 95% confidence interval, 25.5% to 64.7%) achieved a partial response after treatment with rituximab. Median time to response was 3.3 months (range, 2.2 to 7.1 months). Responses occurred in six (40%) of 15 previously untreated patients and in six (50%) of 12 pretreated patients. Patients with a serum immunoglobulin M less than 40 g/L had a significantly higher response rate. The median time to progression for all patients was 16 months, and with a median follow-up of 15.7 months, nine of 12 responding patients remain free of progression. Treatment with rituximab was well tolerated, with approximately one fourth of patients experiencing some mild form of infusion-related toxicity, usually fever and chills. Conclusion: Our prospective data indicate that rituximab is well tolerated and active in patients with WM. Previously untreated and pretreated patients seem to benefit equally. Repeat 4-week courses of rituximab may prolong the duration of response of the disease, but this observation requires confirmation in prospective, randomized trials. Furthermore, studies that will combine rituximab with chemotherapy may be relevant. © 2002 by American Society of Clinical Oncology.

Background: The usefulness of tumor volumetry in ovarian epithelial cancer has never been intensively investigated. The aim of the present study was to determine the value of quantitative analysis of tumor volume as a predictive method for response to treatment and as a prognostic method for disease outcome. Materials and Methods: Seventy-five women with advanced ovarian cancer who presented with measurable disease on CT scan prior to chemotherapy were retrospectively studied. The patients were treated with platinum-based chemotherapy. The median follow-up was 113.36 weeks. An independent radiologist identified and delineated tumor contours in each slice of sequential CT scans before and after therapy. Volumetry was measured with a three-dimensional approach by utilizing a digitizer and a specific algorithm on a software computed program. Results: Data were analyzed according to initial and to residual tumor volumes. Patients with low initial volume of <52 cm3 exhibited higher responses (p<0.01), while patients with medium (52-165 cm3) or high (> 165 CM3) initial tumor volume had a shorter time to progression (p<0.01). Patients without or with low residual volume of <35 cm3 were found to have a longer time to progression (p<0.05) and longer survival (p<0.01 and p<0.05). In addition, serum CA 125 levels followed precisely tumor volumetry for both initial and residual disease. Conclusion: Tumor volumetry in advanced ovarian cancer was found to have predictive value for response to platinum-based chemotherapy. Initial tumor volume has prognostic significance only for the time to progression, whereas residual tumor volume has for both time to progression and survival.