The objective of this study is to examine the synergistic environmental impacts (thermal bioclimatic conditions and air quality due to particulate pollution) with cardiovascular and respiratory syndromes, in Heraklion in the northern part of Crete Island, during a Saharan dust episode on March 22-23, 2008. Daily counts of admissions for cardiovascular and respiratory syndromes were obtained from the two main hospitals in Heraklion. The corresponding daily meteorological parameters, such as maximum and minimum air temperature, relative humidity, wind speed and cloud cover, from the meteorological station of Heraklion (Hellenic National Meteorological Service), were processed in order to estimate and analyze the bioclimatic conditions expressed by the Physiologically Equivalent Temperature (PET), which is based on the energy balance models of the human body. Dust concentrations were derived from the SKIRON forecast model of the University of Athens, while Moderate Resolution Imaging Spectroradiometer (MODIS) products such as aerosol optical depth at 550 nm (AOD550), aerosol small mode fraction (SM), Ångström exponent in the 550-865 nm band and mass concentration, were used for the episode. Besides, daily composite anomalies (reference period: 1968-1996) of the air temperature and vector wind from the middle to the lower atmospheric levels (500 hPa - mean sea level) on March 23, 2008, were calculated from the reanalysis datasets of the National Centers for Environmental Prediction/National Center for Atmospheric Research (NCEP/NCAR). The analysis of MODIS and SKIRON products showed that high AOD 550 values (>0.9) and high dust concentration (>250 μg/m 3), respectively, appear on March 23, 2008, while the respiratory admissions were five-fold than the mean daily admissions on the same day of the emergence of the Saharan dust episode (key day). According to the analysis, this is due to the existence of coarse-mode particles along the dust pathway, which trigger respiratory syndromes more than cardiovascular, which are associated more with ultra-fine particles. The admissions concerning the cardiovascular syndromes did not appear any significant change. The analysis of the bioclimatic conditions on the key day revealed that moderate thermal stress existed and this may be attributed mainly to the geomorphology of the island, which is responsible for special weather conditions such as Fohn winds. The drier atmospheric conditions, as a result of strong, desiccating winds on the leeward side of the mountains, contribute more to the already high hospital admissions for respiratory symptoms. © Gebrüder Borntraeger, Stuttgart 2011.

BACKGROUND: Basal cell carcinoma (BCC) is the most common form of skin cancer with increasing incidence rates worldwide. METHODS: To assess the association of BCC with epidemiologic risk factors in a Southern European population from Greece, we conducted a hospital-based case-control study of 199 patients with BCC and 200 controls. RESULTS: In the multivariate analysis, fair skin colour was associated with increased risk of BCC (OR: 4.9, 95% CI: 2.4-10.0). However, darker skin phototypes III/IV (patient's reported sun sensitivity/tanning ability) showed a higher BCC risk (OR: 3.9, 95% CI: 1.8-8.5). Persons with occupational UV exposure of 5 years or more had a 2.7-fold increased risk (95% CI:1.4-5.3). There was an increased risk of BCC related to the number of sunburns after the age of 20 years (OR: 3.2, 95% CI: 1.4-7.3) and solar lentigines (OR: 6.8, 95% CI: 3.6-12.8). Subgroup analysis showed that different risk factors are associated with early onset BCC including the presence of dysplastic nevi (OR: 6.4, 95% CI: 1.5-27.2), the number of weeks per year spent at the beach during childhood (OR: 8.9, 95% CI: 3.3-24.1) and the history of sunburns during childhood (OR:5.0, 95% CI: 1.3-19.1). CONCLUSIONS: Fair skin colour was significantly associated with BCC risk. The relation of sunburns during adulthood with BCC underlies the importance of sunburn prevention throughout life time. Early onset BCCs seem to have a different pathogenetic background and were associated with dysplastic nevi as well as intermittent sun exposure and sunburns during the early years of life.

In order to investigate differences among infections due to Gram-negative anaerobic bacteria (Bacteroides, Prevotella and Fusobacterium spp.), clinical, epidemiological, and microbiological data were collected and evaluated from 206 anaerobic infections. The most frequently isolated species was Bacteroides fragilis. The majority of the cases were intra-abdominal infections (49%) followed by skin and soft tissue infections (24.7%). Logistic regression analysis showed that Bacteroides spp. strains were more often isolated from intra-abdominal infections (p = 0.002), whereas Prevotella spp. were isolated more frequently from cases with shorter duration of hospitalization (p = 0.026), and less frequently from bloodstream infections (p = 0.049). In addition, Bacteroides spp. were associated with coinfection due to Enterobacteriaceae species (p = 0.007), whereas Prevotella spp. were associated with coinfection due to Staphylococcus spp. (p = 0.002). Patients with an infection due to B. fragilis, were more frequently admitted in a general surgical ward (p = 0.017), or have been treated with a 2nd generation cephalosporin before anaerobic infection onset (p = 0.05). Total mortality was 10.9% and was associated with bacteremia (p = 0.026), and hematological (p = 0.028), or solid organ malignancy (p = 0.007). Metronidazole resistance was detected only among Prevotella spp. (16.2%) and B. fragilis group (0.8%) isolates. In conclusion, this study indicated differences between infections due to the most frequently isolated Gram-negative anaerobic species, differences that may affect the design and implementation of empirical antimicrobial chemotherapy guidelines.

In our discussion of electronic parameters for charge (hole or electron) transfer along DNA we have omitted to mention that, regarding the tight-binding description of hole transport, the corresponding tight-binding parameters should be taken with the opposite sign of the calculated on-site energies and transfer hopping integrals. This means that for describing hole transport at the base-pair level, the on-site energies EbpH presented in the second row of table 2 and the hopping transfer integrals tbpH presented in the second column of table 3 should be used with opposite signs in order to provide the tight-binding parameters of eq. (10). Similarly, for describing hole transport at the single-base level, the on-site energies EbH presented in the eleventh row of table 1 and the hopping transfer integrals tbH presentedin the second column of tables 4–7 should be used with opposite signs in order to provide the tight-binding parameters of eq. (13). Moreover, on p. 300, 8 lines below eq. (14), in the calculation of charge transfer hopping parameters the separation between adjacent base-pairs in B-DNA should read 3.4 ̊A, instead of 3.14 ̊A.

Patients with advanced multiple myeloma (MM) often have increased osteolytic activity of osteoclasts and impaired osteogenesis by osteoblasts, resulting in osteolytic bone lesions that increase the risk of skeletal-related events (SREs) including pathologic fracture, the need for radiotherapy or surgery to bone, and spinal cord compression. Such SREs are potentially life-limiting, and can reduce patients' functional independence and quality of life. Bisphosphonates (e.g., oral clodronate and intravenous pamidronate and zoledronic acid) can inhibit osteoclast-mediated osteolysis, thereby reducing the risk of SREs, ameliorating bone pain, and potentially prolonging survival in patients with MM. Extensive clinical experience demonstrates that bisphosphonates are generally well tolerated, and common adverse events are typically mild and manageable. Studies are ongoing to optimize the timing and duration of bisphosphonate therapy in patients with bone lesions from MM. © 2011 Elsevier Ireland Ltd.

BACKGROUND: The aim of this study was to assess the disease burden of the 2009 pandemic influenza A(H1N1) in Greece. METHODOLOGY/PRINCIPAL FINDINGS: Data on influenza-like illness (ILI), collected through cross-sectional nationwide telephone surveys of 1,000 households in Greece repeated for 25 consecutive weeks, were combined with data from H1N1 virologic surveillance to estimate the incidence and the clinical attack rate (CAR) of influenza A(H1N1). Alternative definitions of ILI (cough or sore throat and fever>38 degrees C [ILI-38] or fever 37.1-38 degrees C [ILI-37]) were used to estimate the number of symptomatic infections. The infection attack rate (IAR) was approximated using estimates from published studies on the frequency of fever in infected individuals. Data on H1N1 morbidity and mortality were used to estimate ICU admission and case fatality (CFR) rates. The epidemic peaked on week 48/2009 with approximately 750-1,500 new cases/100,000 population per week, depending on ILI-38 or ILI-37 case definition, respectively. By week 6/2010, 7.1%-15.6% of the population in Greece was estimated to be symptomatically infected with H1N1. Children 5-19 years represented the most affected population group (CAR:27%-54%), whereas individuals older than 64 years were the least affected (CAR:0.6%-2.2%). The IAR (95% CI) of influenza A(H1N1) was estimated to be 19.7% (13.3%, 26.1%). Per 1,000 symptomatic cases, based on ILI-38 case definition, 416 attended health services, 108 visited hospital emergency departments and 15 were admitted to hospitals. ICU admission rate and CFR were 37 and 17.5 per 100,000 symptomatic cases or 13.4 and 6.3 per 100,000 infections, respectively. CONCLUSIONS/SIGNIFICANCE: Influenza A(H1N1) infected one fifth and caused symptomatic infection in up to 15% of the Greek population. Although individuals older than 65 years were the least affected age group in terms of attack rate, they had 55 and 185 times higher risk of ICU admission and CFR, respectively.

We theoretically and numerically analyze a five-layer "trapped rainbow" waveguide made of a passive negative refractive index (NRI) core layer and gain strips in the cladding. Analytic transfer-matrix calculations and full-wave time-domain simulations are deployed to calculate, both in the frequency and in the time domain, the losses or gain experienced by complex-wave-vector and complex-frequency modes. We find excellent agreement between five distinct sets of results, showing that the use of evanescent pumping (gain) can compensate the losses in the NRI slow- and stopped-light regimes. © 2011 American Physical Society.

Background and Objectives Follow up for breast cancer patients aims at the timely detection of loco-regional recurrences and contralateral breast cancers (LRR). This study investigates the annual risk of LRR after breast conserving treatment (BCT) and the potential value of mammographic surveillance and/or routine clinical examination. Methods Data on 650 women who underwent BCT were obtained and LRR was divided into parenchymal and non-parenchymal. LRR-free and cumulative LRR-free rates were calculated. In patients where recurrence was diagnosed at a routine clinic visit and had negative mammography ("clinical detection only" group) were also separately examined. Results Median follow up was 115 months, range 9-196. Seventy-three patients had parenchymal and 16 nodal recurrence. The median probability of LRR was 1.4% and of parenchymal LRR was 1.32% per year, remaining constant for up to 168 months. The 16 patients in the "clinical detection only" group relapsed mainly during the first 2 years (annual risk 0.77% and 0.80%, respectively). Conclusions This study shows that the risk of parenchymal LRR remains constant for at least 14 years and is significant enough to warrant routine long-term follow up mammography. Routine clinical examination contributes significantly to the detection of LRR only for the first 2 years. © 2011 Wiley-Liss, Inc.

Allergic rhinitis (AR) and chronic idiopathic urticaria (CIU) are highly burdensome diseases, which are increasing in prevalence, especially in the paediatric population. Despite the availability of a large number of medications for treatment of AR and CIU, their use in children has primarily been based on data obtained from a limited number of clinical trials in children and/or testing in adults. The H(1)-antihistamines have traditionally been used as first-line treatment for the relief of both AR and CIU symptoms in children. The first-generation H(1)-antihistamines are associated with marked adverse effects such as sedation, sleepiness/drowsiness as well as difficulties in learning and cognitive processing; thus, they are recommended for limited or discontinued use in children with AR or CIU. In contrast, second-generation H(1)-antihistamines are more adapted for the use in children with AR and CIU due to better safety profiles. However, only a limited number of trials with these agents have been conducted and generally, data from well-designed trials in children are lacking. Levocetirizine is one of the most extensively investigated H(1)-antihistamines for its pharmacologic properties, safety, efficacy as well as overall global satisfaction in children aged 2-12 years. Levocetirizine is the only H(1)-antihistamine launched in the 21st century shown to lack clinically relevant adverse effects on physical and psychomotor development or routine laboratory tests over a long-term period of 18 months in 1- to 3-year-old children predisposed to development of allergic disease. Available data suggest that levocetirizine is a suitable treatment option for AR and CIU in children aged 6 months to 12 years.

BACKGROUND: The effectiveness of a new delivery system consisting of polymerized dilactide (PLA) with incorporated linezolid was investigated in a rabbit model as a means of treating methicillin-resistant Staphylococcus aureus (MRSA) osteomyelitis. METHODS: The PLA-linezolid system was prepared after thorough stirring of PLA with linezolid at a 10:1 ratio. Experimental osteomyelitis was established in 40 rabbits by a modification of the Norden model with MRSA as the test isolate. After a hole had been drilled in the upper right femur, the isolate was inoculated using a thin needle working as a foreign body. At three weeks, the needle was removed and cultured, and the PLA-linezolid system was implanted in half the animals (group B); the remaining half was the control group (group A). Animals were sacrificed at regular intervals; tissue around the site of implantation was examined for pathologic changes and cultured quantitatively. RESULTS: The prepared system eluted linezolid in vitro at concentrations much greater than the minimum inhibitory concentration (MIC) of the test pathogen for 11 days. At three weeks after inoculation of the test isolate, all animals had osteomyelitis. By the sixth week, bacterial growth from cancellous bone of group B was significantly lower than that in group A. However, this effect was not maintained until the end of the study (weeks 8 and 10), when the differences in bacterial growth in the two groups were not significant. CONCLUSION: Polymerized dilactide mixed with 10% linezolid achieved partial arrest of the offending pathogen in an experimental model of osteomyelitis caused by MRSA.

C-C motif ligand 3 (CCL3) chemokine plays a crucial role in the inflammation process, cell migration and chemoattraction of monocytes/ macrophages, neutrophils and mast cells. CCL3 is overexpressed by malignant cells in B-cell disorders, including chronic lymphocytic leukemia and multiple myeloma. Elevated circulating CCL3 was previously described in Waldenström's macroglobulinemia (WM) but the source of its production was unknown. We performed an immunohistochemical study in bone marrow biopsies of 67 WM patients and found that the whole number of the neoplastic cells express CCL3 in all cases. This finding was constant in newly diagnosed patients with both symptomatic and asymptomatic WM and also in patients with active disease post previous therapies. Our results support, for the first time in the literature, the production of CCL3 by WM cells. They also suggest a possible role of CCL3 in WM biology and reveal CCL3 as a potential target for developing novel drugs against WM. © 2011 Elsevier Inc. All rights reserved.

We investigate the uniform limits of the set of polynomials on the closed unit disc D¯"> with respect to the chordal metric χ. More generally, we examine analogous questions replacing the one-point compactification of CC∪{∞}"> by other metrizable compactifications.

INTRODUCTION: The aim of this study was to assess the changes in inclination of the maxillary second (M2) and third (M3) molars after orthodontic treatment of Class II Division 1 malocclusion with extraction of maxillary first molars. METHODS: Two groups of subjects were studied. The experimental group consisted of 37 subjects, 18 boys and 19 girls (mean age, 13.2 ± 1.62 years). The inclusion criteria were white origin, Class II Division 1 malocclusion, overjet ≥4 mm, no missing teeth or agenesis, and maxillary M3 present. All patients were treated with extraction of the maxillary first molars and the Begg technique. Standardized lateral cephalometric radiographs were taken at the start of active treatment (T1) and at least 3.7 years posttreatment (T2). The control group was drawn from the archives of the Nittedal Growth Material (Oslo University, Oslo, Norway) and included 54 untreated Class I and Class II subjects,18 boys and 36 girls (mean age, 13.4 ± 1.99 years) followed up for a minimum of 3.6 years. M2 and M3 inclinations relative to the palatal plane (PP) and functional occlusal plane (FOP) were measured and compared between groups and time periods. RESULTS: M2 to PP inclination improved significantly in both the control group (M2-PP at T1, 17.7° ± 5.81°, and at T2, 11.9° ± 4.61°) and the experimental group (M2-PP at T1, 26.7° ± 5.75°, and at T2, 6.9° ± 6.76°). There were also significant increases of the mesial inclination of M3 in the control group (M3-PP at T1, 30.1° ± 8.54°, and at T2, 19.6° ± 9.01°) and extraction group (M3-PP at T1, 32.2° ± 7.90°, and at T2, 12.8° ± 7.36°). By using the FOP as the reference system, no significant change in the inclination of M2 was observed in the control group, whereas, in the extraction group, although more distally inclined at T1, M2 ended up mesially inclined at T2 (M2-FOP at T1, 14.2° ± 4.62°, and at T2, -6.2° ± 6.10°; P <0.0001). M3 inclinations were similar between the groups at T1 (M3-FOP control, 17.3° ± 9.35°; M3-FOP experimental, 19.6° ± 7.37°), and these improved significantly in both groups. However, M3 uprighting was almost 4 times greater in the extraction group (M3-FOP from T2-T1, 5.6° vs 19.9°). The greatest distal inclination of M3 at T2 in the extraction group was 9.4°, a value attained by only 43% of the control group. CONCLUSIONS: Extraction of the maxillary first molars in Class II Division 1 patients results in significant uprighting of M2 and M3 and facilitates the normal eruption of M3.

Launching the distance-learning student-tutor interaction process, tutors of the first module of the M.Ed in English course at the HOU lay the foundations of academic student autonomy by means of providing – inter alia -- the appropriate written feedback on written assignments. In doing so, they need to gauge the content and form of their written comments systematically with regard to both output- and student-, that is human factor-related issues (cf. Goldstein, 2004), the latter being particularly relevant to the distance-learning context. In this article we discuss tutor policy as well as tutor perceptions (cf. Lee, 2004, 2009 among others) regarding written feedback on students’ academic assignments in terms of aspects of deviance treated and the relative gravity of ‘global’ and ‘local’ errors (e.g. Ferris, 2002), the directness of the correction, the punitive or facilitative nature of the comments provided as well as the relative balance of student strengths and weaknesses on the tutor’s comment agenda (cf. Hyland & Hyland, 2006). The role of the tutor as an assessor and/or counsellor is explored and the importance of striking a delicate balance between the two, especially in a context where face-to-face feedback opportunities are severely restricted, is underscored. We suggest that distance-learning feedback practices may need to be at least partially individualized to maximize student response and meet the goal of ‘informed autonomy’.

The highly oriented filamentous protein network of muscle constantly experiences significant mechanical load during muscle operation. The dimeric protein myomesin has been identified as an important M-band component supporting the mechanical integrity of the entire sarcomere. Recent structural studies have revealed a long alpha-helical linker between the C-terminal immunoglobulin (Ig) domains My12 and My13 of myomesin. In this paper, we have used single-molecule force spectroscopy in combination with molecular dynamics simulations to characterize the mechanics of the myomesin dimer comprising immunoglobulin domains My12-My13. We find that at forces of approximately 30 pN the alpha-helical linker reversibly elongates allowing the molecule to extend by more than the folded extension of a full domain. High-resolution measurements directly reveal the equilibrium folding/unfolding kinetics of the individual helix. We show that alpha-helix unfolding mechanically protects the molecule homodimerization from dissociation at physiologically relevant forces. As fast and reversible molecular springs the myomesin alpha-helical linkers are an essential component for the structural integrity of the M band.

In this paper we propose a feature-based analysis of Cappadocian Greek nominal inflection. In particular, based on the formal description of Standard Greek nominal inflection by Ralli (2000), we identify the inflectional formatives and analyse them as bundles of features expressing number, case, animacy and inflectional class. The feature specification of each ending determines its distribution in the relevant variety. Similarly, inflectional classes are defined on the basis of (a) the compatibility of a given noun with an inflectional pattern and (b) the base alternations it exhibits. Such an approach has the advantage of accounting for the variation in base formation and for the agglutinative inflectional patterns by means of systematic base allomorphy and default formatives.

For a nitrogen dimer in insulating MgO, a ferromagnetic coupling between spin-polarized 2p holes is revealed by calculations based on the density functional theory amended by an on-site Coulomb interaction and corroborated by the Hubbard model. It is shown that the ferromagnetic coupling is facilitated by a T-shaped orbital arrangement of the 2p holes, which is in its turn controlled by an intersite Coulomb interaction due to the directionality of the p orbitals. We thus conjecture that this interaction is an important ingredient of ferromagnetism in band insulators with 2p dopants.

Objectives: Bone disease is a key presenting feature of myeloma. This post hoc analysis of the phase III VISTA trial of bortezomib plus melphalan-prednisone (VMP) vs. MP in previously untreated myeloma patients assessed clinical bone disease events and changes in alkaline phosphatase (ALP), a marker for osteoblast activation, and serum Dickkopf-1 (DKK-1), an inhibitor of osteoblast differentiation, during treatment. Methods: Patients received nine 6-wk cycles of VMP (bortezomib 1.3mg/m 2, days 1, 4, 8, 11, 22, 25, 29, 32, cycles 1-4, days 1, 8, 22, 29, cycles 5-9, plus melphalan 9mg/m 2 and prednisone 60mg/m 2, days 1-4, cycles 1-9; N=344) or MP alone (N=338). Results: Rates of bisphosphonates use during treatment (73% vs. 82%), progression because of worsening bone disease (3% vs. 11%), and requirement for subsequent radiotherapy (3% vs. 8%) were lower with VMP vs. MP. Median maximum ALP increase was significantly higher with VMP vs. MP overall (49.7% vs. 30.3%, P=0.029), and higher by response group (complete response [CR]: 68.7% vs. 43.9%; partial response [PR]: 41.5% vs. 31.2%). Greater maximum ALP increase was strongly associated with achievement of CR (P≤0.0001) and CR/PR (P≤0.01). Median DKK-1 decreased with VMP by 694.4pg/mL and increased with MP by 1273.3pg/mL from baseline to day 4 (P=0.0069). Available radiologic data revealed evidence of bone healing in 6/11 VMP-treated patients, who achieved best responses of three CR, one PR, and two stable disease. Conclusions: These results suggest a positive effect of bortezomib on bone metabolism and potentially bone healing in myeloma. © 2011 John Wiley and Sons A/S.

On the occasion of the tenth anniversary of the Μ.Ed. in TESOL programme of the Hellenic Open University, we distributed a questionnaire to graduates as well as current students of the programme. Our primary goal was to further reflect on the usefulness of the programme ten years after and identify possible weak points that need enhancement for the ultimate benefit of our students and the Greek society at large. To that end, we aimed to map out students’ views about the programme and its influence on their professional life. In the various sections of the questionnaire we tried to explore (a) whether their expectations are fulfilled; (b) which modules of those on offer they have selected and which they consider as the most and least important for their professional training and development; (c) how the programme has influenced the professional choices they make/have made outside teaching a class-proper; (d) whether they regard the programme as a springboard for further professional development which they can embark upon on their own; (e) what suggestions they can make for the programme’s further improvement of. The results were very positive. The goals we had set forth in 1998, when this Μ.Ed. in TESOL teacher education programme was inaugurated, were definitely fulfilled for the benefit of the teachers of English at large both in the private and the state sector. The work that has been carried out so far points to a bright future, provided we continue on the same successful course and implement all necessary changes and adjustments required by our changing times.

We prospectively studied 110 consecutive patients with intertrochanteric hip fractures treated with the 130 degree angle, 10-mm short IMHS intramedullary hip screw (IMHS, Smith & Nephew, Richards, Memphis, TN). Surgery was performed within 36 hours from admission; all patients were mobilized immediately postoperatively. Fracture union, pre- and post-operative mobility status and complications were evaluated. Eighty patients were included in the postoperative evaluation for a mean followup of 14 (range, 9 to 25) months. Mortality was 19%. Union occurred in 79 fractures within 6 months from surgery; there was one case of screw cut-out and one case of deep venous thrombosis. Periprosthetic femoral shaft fractures were not observed. At the latest examination, the mean mobility score decreased from 8.4 +/- 1.6 to 7.1 +/- 2.1 (p = 0.0001); 26 patients (32%) fully achieved the preoperative mobility score and 54 patients (68%) achieved more than 90% of the preoperative mobility score. The IMHS intramedullary hip screw represents a reliable method for the treatment of patients with intertrochanteric hip fractures, and provides for early mobilization and rehabilitation of the patients with acceptable complications.

This research applies the fuzzy set theory via Geographical Information Systems (GIS) - based analysis to investigate the slope erosion by water. The main steps of this procedure are the definition of the input variables (rocks’ susceptibility to erosion, slope angle, slope morphology), the development of a fuzzy inference system based on theoretical and empirical knowledge, transforming the input to output variables (erosion – deposition) and the visualization of the output variables (spatial distribution of the erosion-deposition processes). The method was applied at the Corinth drainage basin, located in the north-eastern part of Peloponnese (Greece), where a series of catastrophic erosional events have recently occurred.

Photonic metamaterials allow for a range of exciting applications unattainable with ordinary dielectrics. However, the metallic nature of their meta-atoms may result in increased optical losses. Gain-enhanced metamaterials are a potential solution to this problem, but the conception of realistic, three-dimensional designs is a challenging task. Starting from fundamental electrodynamic and quantum mechanical equations, we establish and deploy a rigorous theoretical model for the spatial and temporal interaction of lightwaves with free and bound electrons inside and around metallic (nano-) structures and gain media. The derived numerical framework allows us to self-consistently study the dynamics and impact of the coherent plasmon-gain interaction, nonlinear saturation, field enhancement, radiative damping and spatial dispersion. Using numerical pump-probe experiments on a double-fishnet metamaterial structure with dye molecule inclusions, we investigate the build-up of the inversion profile and the formation of the plasmonic modes in a low-Q cavity. We find that full loss compensation occurs in a regime where the real part of the effective refractive index of the metamaterial becomes more negative compared to the passive case. Our results provide a deep insight into how internal processes affect the overall optical properties of active photonic metamaterials fostering new approaches to the design of practical, loss-compensated plasmonic nanostructures. © 2011 The Royal Society.

We outline the theory of slow-light propagation in waveguides featuring negative electromagnetic parameters (permittivity, permeability and/or refractive index). We explain the mechanism by which these heterostructures can enable stopping of light even in the presence of disorder and, simultaneously, dissipative losses. Using full-wave numerical simulations and analytical transfer-matrix calculations we show that the incorporation of thin layers made of an active medium adjacently to the core layer of a negative-refractive-index waveguide can completely remove dissipative losses - in a slow- or stopped-light regime where the effective index of the guided lightwave remains negative. We also review and compare several 'trapped rainbow' schemes that have recently been proposed for slowing and stopping waves. © 2011 SPIE.

During cortical development, coordination of proliferation and differentiation ensures the timely generation of different neural progenitor lineages that will give rise to mature neurons and glia. Geminin is an inhibitor of DNA replication and it has been proposed to regulate cell proliferation and fate determination during neurogenesis via interactions with transcription factors and chromatin remodeling complexes. To investigate the in vivo role of Geminin in the maintenance and differentiation of cortical neural progenitors, we have generated mice that lack Geminin expression in the developing cortex. Our results show that loss of Geminin leads to the expansion of neural progenitor cells located at the ventricular and subventricular zones of the developing cortex. Early cortical progenitors lacking Geminin exhibit a longer S-phase and a reduced ability to generate early born neurons, consistent with a preference on self-renewing divisions. Overexpression of Geminin in progenitor cells of the cortex reduces the number of neural progenitor cells, promotes cell cycle exit and subsequent neuronal differentiation. Our study suggests that Geminin has an important role during cortical development in regulating progenitor number and ultimately neuron generation.

Digital Assembly presentation, Brussels  June 17, 2011-------------------------------------------------------------------------------------------------------------------------------------------------- How can we move from gender devaluation and gender fatigue to gender energy and get more women to ride up the glass escalator? Current research indicates the need to focus on innovative approaches to getting gender back onto the agenda: reproducing women’s recruitment, retention, advancement and agency (Farrington 2011, Kamberidou 2010, Kelan 2010, Merriman 2010, Benschop & Brouns 2003, Hultin 2003). Despite legislation and gender mainstreaming policies, the recognition by many companies, organizations and institutions that diversity is essential, women still lag behind men in compensation and advancement and are less satisfied with their careers than men. Women are overlooked in decision making positions in the business sector, in S&R, in the academia, on research committees, etc. This paper examines three major gender gaps: 1) the leadership gap, 2) the pay gap and 3) the engagement/participation gap, with references to the phenomena of gender fatigue, tokenism and the hidden advantages for men in the so-called 'female' professions. Taking their gender privilege with them, men experience positive discrimination in female dominated professions and are promoted up the ladder (ride up the glass escalator) even faster than their female counterparts, as opposed to women who confront the glass ceiling and the sticky floor in male dominated fields. Gender devaluation, namely the subtle processes by which women’s contributions are minimized, undervalued or devalued in male dominated professions are especially apparent in the academia as well. Consequently, "getting gender back on the agenda" (Kamberidou 2010) requires an Alternative Model—redefining professional success and concepts of excellence, finding alternative paths to advancement or tenure, establishing measures and best practices at many levels—examined in the strategy proposals presented in this paper. Research shows that women are an economic force to be reckoned with and utilizing the entire talent provides an important competitive advantage. Studies confirm that companies that recognise talent in any form and make good use of it show greater success with regard to profits and sustainability. Women must be present in sufficient numbers at senior levels in order to achieve better results and especially to drive cultural change.   Keywords: gender fatigue, the ‘stupid curve’: wastage of talent, the glass escalator, tokenism, gender devaluation, gender-blind academic structures      

Zymomonas mobilis is an alphaproteobacterium studied for bioethanol production. Different strains of this organism have been hitherto sequenced; they all belong to the Z. mobilis subsp. mobilis taxon. Here we report the finished and annotated genome sequence of strain ATCC 29192, a cider-spoiling agent isolated in the United Kingdom. ATCC 29192 is the lectotype of the second-best-characterized subspecies of Z. mobilis, Z. mobilis subsp. pomaceae. The nucleotide sequence of ATCC 29192 deviates from that of Z. mobilis subsp. mobilis representatives, which justifies its distinct taxonomic positioning and proves particularly useful for comparative and functional genomic analyses.

Zymomonas mobilis ATCC 10988 is the type strain of the Z. mobilis subsp. mobilis taxon, members of which are some of the most rigorous ethanol-producing bacteria. Isolated from Agave cactus fermentations in Mexico, ATCC 10988 is one of the first Z. mobilis strains to be described and studied. Its robustness in sucrose-substrate fermentations, physiological characteristics, large number of plasmids, and overall genomic plasticity render this strain important to the study of the species. Here we report the finishing and annotation of the ATCC 10988 chromosomal and plasmid genome.

Cette contribution au volume consacré à l’identité féminine dans l’oeuvre d’Elsa Triolet tente de décrypter la pensée « féministe » de l’auteure à travers ses écrits personnels et autobiographiques, ses articles et reportages, les discours également prononcés dans le cadre des manifestations organisées par l’Union des Femmes Françaises. Dans une première partie sont examinées ses conceptions sur les rapports des sexes. Triolet réfute haut et fort la supériorité des hommes sur les femmes et condamne la ségrégation des sexes. Selon l’auteure l’être humain n’est pas fait que de « féminin » ou que de « masculin ». La société devrait être donc construite à l’image de cet être mixte : elle prône alors un univers bisexué, un langage aussi dans lequel les deux sexes seraient visibles. Pour y arriver, elle invite à un « féminisme individuel », un féminisme quotidien. C’est qu’elle rejette l’idée de la mobilisation collective des femmes : à son sens, cette forme de lutte représente une autre manifestation du « ghetto » qu’elle abhorre. Fidèle à ces convictions, elle choisit de promouvoir des causes qui s’inscrivent dans le cadre plus large de l’action des intellectuelles de gauche proches du PCF. Dans la deuxième partie, il est question de son engagement dans la Résistance. Au cours de cette période de sa vie, Triolet se soumet en apparence à la répartition sexuée des rôles. Le « je » féminin recouvre ses droits dans ses seuls écrits portant sur cette période : moment transitionnel, la guerre bouleverse les équilibres et les assignations, brouille les identités. Ces textes participent ainsi à la construction d’une mémoire communiste de la Résistance au féminin. La troisième partie est consacrée au combat de Triolet, compagnon de route du PCF, contre l’invasion d’une culture américaine en France. En pleine guerre froide, l’auteure ne dissocie pas la lutte en faveur d’une littérature « progressiste » de celle pour la paix : les femmes pourraient contribuer à la propagation de cette culture, seule arme contre la guerre. Fidèle à la ligne du Parti, elle ne cesse de valoriser - quand l’Union des Femmes Françaises fait appel à elle – cet aspect du rôle social féminin. Pour expliquer la propension des hommes à la guerre, elle a recours au schéma nature/culture : elle considère que seule la paix est conforme à la nature des deux sexes, le bellicisme étant ainsi présenté comme une construction sociale ; or, la nature masculine n’est pas perméable au conditionnement social, d’où la supériorité naturelle des femmes dont la présence dans la sphère publique constitue, de ce fait, une condition indispensable au progrès humain.L’errance à travers les textes d’Elsa Triolet conduit donc à la constatation que sa pensée « féministe » se forme sous le signe de la contradiction due aussi à son appartenance politique : adhésion à un féminisme de l’égalité dans son discours introspectif mais, dans la sphère publique, promotion du différentialisme sexuel ; lutte individuelle pour l’égalité avec les hommes et, parallèlement, rejet d’une action féministe collective au nom d’une société mixte et égalitaire.

A B S T R A C THow genres can be used to enhance pragmatic competence is an issue not adequately explored. Pragmatic competence is defined in this paper as a twofold ability relying on two types of competence: (a) pragmatic awareness, i.e. the ability to correctly identify pragmatically inferred effects in the form of implicated conclusions, e.g. irony, humour, contempt, respect, favouring, or incriminating attitudes conveyed by different text-types, and (b) metapragmatic awareness, the ability to meta-represent and explicate the link between relevant linguistic indexes and pragmatic effects retrieved by readers. Results from non-native university learners of English indicate that explicit genre-based instruction has significant positive effects on the development of genre-focused, convention-specific discourse but not on the development of pragmatic competence in low-level language proficiency learners. A positive correlation between language proficiency and pragmatic competence is further consolidated by the data.

Methane Hydrates are a new energy resource in the global energy market which has received extreme attention from a technological and geopolitical point of view. The reserve estimates exceed by far the overall estimates of all the other conventional energy reserves. With the existing technological know-how the exploitation of methane hydrates is expected to dominate the international energy market within the next 10-15 years. Methane hydrates have been mapped within the Hellenic Submarine Space and especially in the region of Kastellorizo, with whatever consequences it may have of geostrategic nature for the political decisions of Greece and its relations with the neighbouring countries and the delimitation of its EEZ.

In Greece, there is no officially organized training in clinical chemistry for scientists. The Greek Society of Clinical Chemistry-Clinical Biochemistry (GSCC-CB), following the encouragement of the EC4/RC decided to organize a voluntary Register for specialists in clinical chemistry. The following criteria for registration were defined: 1) University degree in Chemistry, Biochemistry, Biology, Medicine, Pharmacy or other relevant subject. 2) A total of 9 years of university studies and postgraduate specialization in clinical chemistry-clinical biochemistry. 3) A minimum of 4 years of postgraduate specialization in clinical chemistry-clinical biochemistry on the job. 4) The candidate must be practicing clinical chemistry-clinical biochemistry in a laboratory in a medical environment in Greece. The postgraduate specialization in clinical chemistry-clinical biochemistry includes the laboratory training and the theoretical education. The laboratory training is organized by the GSCC-CB according to the Professional Training Dossier. The theoretical education was organized in a series of 18 "Seminars" which was the content of the "Educational program" of the GSCC-CB. Successful completion of the Educational program leads to a Certificate of Competence. The Greek Register has gained equivalence with the EC4 Register and it has 218 members, more than 80 of whom are European clinical chemists. © 2011 by Walter de Gruyter.

Ζούμε σε έναν κόσμο που γίνεται όλο και πιο σύνθετος, πολύπλοκος και αντιφατικός. Παράλληλα, τα μέσα επικοινωνίας καταλαμβάνουν κυρίαρχη θέση σε αυτό τον κόσμο και συνήθως υπερισχύουν άλλων τομέων της κοινωνίας, αλλά και της οικονομίας. Συχνά, οι περισσότεροι κοινωνικοί θεσμοί, αν όχι όλοι, εξαναγκάζονται να προσαρμοστούν στις απαιτήσεις της σύγχρονης «διαμεσολαβημένης» κοινωνίας. Στόχος του βιβλίου είναι να αναδειχθούν σύγχρονα ζητήματα που απασχολούν το σύγχρονο και πολυσύνθετο πεδίο της επικοινωνίας. Οι συγγραφείς του βιβλίου θίγουν ζητήματα που απασχολούν τους μελετητές όσον αφορά στη σχέση των μέσων επικοινωνίας και της κοινωνίας στον 21ο αιώνα, και αναλύουν τις αλλαγές που έχουν συντελεστεί στο πεδίο της επικοινωνίας, στο επίπεδο της θεωρίας, της δομής και, πιο συγκεκριμένα, στους χώρους της ενημέρωσης, της πολιτικής, της δημοσιογραφίας και των σχέσεων των πολιτών με τα νέα μέσα επικοινωνίας.

Purpose – The purpose of this paper is to explore the concept of health-related needs on a policy design and curriculum enactment basis in terms of the national school health education curriculum in Greek secondary education. Design/methodology/approach – A single case study, using an ethnographic approach, was conducted in Greece, seeking to understand the continuum from policy design to curriculum enactment in respect of health-related needs. Three sources of data were used to meet this goal: policy texts, observation, and interviews. Multilevel sampling was employed to select one secondary school as a site for “good practice”. Grounded theory coding, thematic analysis and critical discourse analysis identified themes associated with the idea of health-related through the corpus of data. Findings – On a policy plan level the concept of health-related needs was coupled with and reduced to a predetermined list of health-related subjects; and the list of health-related topics had not been updated for long and was characterised by a rather biomedical orientation. On a school practice level the stage of needs assessment was not applied, the list of health-related subjects advocated in the policy plan was used on a proactive, normative and top down basis, and the students' felt needs tended to be disregarded. Originality/value – This study followed up the continuum from policy design to school practice regarding the concept and practice of health needs, highlighting the possibilities and the problems from both perspectives.

BACKGROUND: FAD dependent glucose dehydrogenase (GDH) currently raises enormous interest in the field of glucose biosensors. Due to its superior properties such as high turnover rate, substrate specificity and oxygen independence, GDH makes its way into glucose biosensing. The recently discovered GDH from the ascomycete Glomerella cingulata is a novel candidate for such an electrochemical application, but also of interest to study the plant-pathogen interaction of a family of wide-spread, crop destroying fungi. Heterologous expression is a necessity to facilitate the production of GDH for biotechnological applications and to study its physiological role in the outbreak of anthracnose caused by Glomerella (anamorph Colletotrichum) spp. RESULTS: Heterologous expression of active G. cingulata GDH has been achieved in both Escherichia coli and Pichia pastoris, however, the expressed volumetric activity was about 4800-fold higher in P. pastoris. Expression in E. coli resulted mainly in the formation of inclusion bodies and only after co-expression with molecular chaperones enzymatic activity was detected. The fed-batch cultivation of a P. pastoris transformant resulted in an expression of 48,000 U L(-)(1) of GDH activity (57 mg L(-)(1)). Recombinant GDH was purified by a two-step purification procedure with a yield of 71%. Comparative characterization of molecular and catalytic properties shows identical features for the GDH expressed in P. pastoris and the wild-type enzyme from its natural fungal source. CONCLUSIONS: The heterologous expression of active GDH was greatly favoured in the eukaryotic host. The efficient expression in P. pastoris facilitates the production of genetically engineered GDH variants for electrochemical-, physiological- and structural studies.

The histidine-rich calcium binding protein (HRC) is a novel regulator of sarcoplasmic reticulum (SR) Ca(2+)-uptake, storage and release. Residing in the SR lumen, HRC binds Ca(2+) with high capacity but low affinity. In vitro phosphorylation of HRC affects ryanodine affinity of the ryanodine receptor (RyR), suggesting a functional role of HRC on SR Ca(2+)-release. Indeed, acute HRC overexpression in isolated rodent cardiomyocytes decreases Ca(2+)-induced Ca(2+)-release, increases SR Ca(2+)-load, and impairs contractility. The HRC effects on RyR may be regulated by the Ca(2+)-sensitivity of its interaction with triadin. However, HRC also affects the SR Ca(2+)-ATPase, as shown by HRC overexpression in transgenic mouse hearts, which resulted in reduced SR Ca(2+)-uptake rates, cardiac remodeling and hypertrophy. In fact, in vitro generated evidence suggests that HRC directly interacts with SR Ca(2+)-ATPase2, supporting a dual role of HRC in Ca(2+)-homeostasis: regulation of both SR Ca(2+)-uptake and Ca(2+)-release. Furthermore, HRC plays an important role in myocyte differentiation and in antiapoptotic cardioprotection against ischemia/reperfusion induced cardiac injury. Interestingly, HRC has been linked with familiar cardiac conduction disease and an HRC polymorphism was shown to associate with malignant ventricular arrhythmias in the background of idiopathic dilated cardiomyopathy. This review summarizes studies, which have established the critical role of HRC in Ca(2+)-homeostasis, suggesting its importance in cardiac physiology and pathophysiology.

Ce travail se penche sur un aspect de la coopération franco-hellénique dans le domaine de la formation au professorat de français. Elle porte plus précisément sur la période 1954-1991 et étudie la mise sur pied à l’université d’Athènes d’une structure de préparation professionnelle destinée aux francisants. La France participe à cette entreprise avec une équipe enseignante composée de docteurs d’État, d’agrégés et de licenciés. L’étude examine le cadre de cohabitation, au sein de la Section française d’abord, du Département de langue et littérature françaises plus tard, de deux personnels, français et grec, qui tout en ayant un but commun, devaient, en même temps, servir les politiques culturelles/éducatives de leur pays respectif. Elle constitue un premier bilan des résultats d’une recherche en cours.Dans la première partie qui couvre la période 1954-1976, est évoqué, en premier lieu, le contexte géopolitique en pleine reconstruction qui émerge après la Seconde Guerre mondiale et qui conduit à une redistribution des zones d’influence entre les grandes puissances occidentales dans le domaine linguistique et culturel. Ces mutations entraînent, d’une part, la perte des privilèges français dans ce domaine et, d’autre part, une reformulation des stratégies universitaires concernant la formation des professeurs de langues étrangères ; celles-ci se concrétisent par la création de sections universitaires de préparation à cette spécialité. Suit l’examen des textes législatifs constitutifs de la Section française qui révèle les choix stratégiques qui ont prévalu et la philosophie qui a présidé lors de leur élaboration : former des fonctionnaires hellènes imbus d’une culture gréco-française ; placer cette structure sous la haute surveillance des autorités universitaires. L’analyse s’intéresse plus particulièrement au partenariat entre les deux équipes, française et grecque, inauguré par la loi de 1954. Cette collaboration n’était pas conçue sur un pied d’égalité : la loi réservait un rôle subordonné à la partie française. Il n’empêche que la responsabilité administrative de la Section (gestion économique et coordination des auxiliaires d’enseignement) était assumée par l’un des deux titulaires français des chaires créées. Une première approche du profil de l’équipe française, groupe de fonctionnaires migrants, est tentée dans un deuxième temps : composition sexuée, titres, durée des missions, difficultés de recrutement. Cette première partie se termine par une brève étude du groupe quasi-féminin de maîtres-assistant.e.s grec.que.s constitué à partir de 1964 pour faire face à l’augmentation vertigineuse de la population étudiante. La deuxième partie du travail qui examine la période 1976-1991 met en relief le processus de désengagement de la partie française de la direction de la Section. Cette rupture est le résultat de la réorientation des politiques culturelles françaises dans le domaine de l’enseignement à l’étranger. De leur côté, les professeurs grecs mettent en place les structures adéquates qui permettront l’affranchissement des sections universitaires de langues vivantes de la tutelle étrangère : création de chaires, recrutement d’un personnel grec plus nombreux et mieux instruit. Ces stratégies conduisent inévitablement à l’hellénisation et à la féminisation des structures de formation en question. En 1991, prend fin la mission du dernier lecteur français à la Section française athénienne et avec elle la collaboration franco-hellénique dans ce domaine.

The historical variation of scientific knowledge has lent itself to the development of historical epistemology, which attempts to historicize the origin and establishment of knowledge claims. The questions I address in this paper revolve around the historicity of the objects of those claims: How and why do new scientific objects appear? What exactly comes into being in such cases? Do scientific objects evolve over time and in what ways? I put forward and defend two theses: First, the ontology of science is so rich and variegated that there are no universally valid answers to these questions. Second, we need a pluralist account of scientific objects, a pluralist metaphysics that can do justice to their rich diversity and their various modes of being and becoming. I then focus on hidden objects, which are supposed to be part of the permanent furniture of the universe, and I discuss their birth and historicity: They emerge when various phenomena coalesce as manifestations of a single hidden cause and their representations change over time. Finally, I examine the conditions under which an evolving representation may still refer to the same object and I illustrate my argument drawing upon the early history of electrons.

The Eastern Mediterranean Sea lies in a climatological transition zone, under the influence of both tropical and mid-latitude climate processes. Within this basin, the Aegean Sea has been recognized as a highly sensitive area to global/regional climate change. Sediment archives provide robust evidence for changes in its hydrological properties and biogeochemical functioning as a response to past climate variability. In order to investigate the region's paleoclimatic and paleoceanographic patterns during the Holocene, with a special emphasis on the sapropel S1 interval, we have investigated marine sediment cores along a N-S transect in the Aegean and the S. Cretan Seas. We focus on combined geochemical, micropaleontological and palynological proxies, namely organic biomarkers, organic carbon and nitrogen stable isotopes, coccolithophore and pollen assemblages, aiming at reconstructing climate-related parameters such as sea surface temperature (SST), marine productivity patterns, stratification and nutricline fluctuations, continental vegetation patterns and land-sea interactions. SST patterns depict major global/regional climate fluctuations during the last glacial and deglaciation periods, depict the warm transition to the Holocene optimum, when the formation of the S1 sapropel takes place, a distinct cool episode around 8 ka BP (coeval with the S1 interruption), a conspicuous mid-Holocene warm phase (5.4-4.3 ka BP) as well as other distinct fluctuations. Diagnostic marine lipids, δ15N, and coccolithophore assemblages allow documenting the variability of primary productivity and associated organic carbon accumulation in sediments, as well as fluctuations in water column stratification and nutricline, especially during the deposition of the S1 sapropel. Combined terrigenous proxies record warm/cool and dry/humid time intervals, allowing land-sea correlations, and document changes in the delivery of terrestrial material to the sea related to climate-driven fluctuations in freshwater discharges. The network of sediment cores studied provide a better constrain of the regional climate patterns in the northeastern Mediterranean Sea and enables assessing potential time lags and gradients.

Detailed mapping of coastline around Theologos area revealed the existence of well developed permanently submerged notches 75 ± 10 cm below present mean sea level. The regional occurrence of well preserved submerged tidal notches suggests their coseismic origin. The submergence of this Holocene shoreline possibly occurred at 1894 AD. Average submergence rate of 6.08 mm/yr may be estimated by a well preserved recumbent U-shaped notch. The retreating point depth suggests that the developing period of the notch might have been of the order of as much as three thousand years. Several non in situ large rock blocks, containing marine fossils (Lithophaga, Vermetids, Serpulids) in growth position, seem to have been projected on the coast by a tsunami wave, which might have been caused by the same coseismic episode.

In an effort to increase ethanol productivity during the consolidated bioprocessing (CBP) of lignocellulosics by Fusarium oxysporum, we attempted the constitutive homologous overexpression of one of the key process enzymes, namely an endo-xylanase. The endo-β-1,4-xylanase 2 gene was incorporated into the F. oxysporum genome under the regulation of the gpdA promoter of Aspergillus nidulans. The transformation was effected through Agrobacterium tumefaciens and resulted in 12 transformants, two of which were selected for further study due to their high extracellular xylanase activities under normally repressing conditions (glucose as sole carbon source). During natural induction conditions (growth on xylan) though, the extracellular enzyme levels of the transformants were only marginally higher (5–10%) compared to the wild type despite the significantly stronger xylanase 2 mRNA signals. SDS-PAGE verified enzyme assay results that there was no intracellular xylanase 2 accumulation in the transformants, suggesting the potential regulation in a post transcriptional or translational level. The fermentative performance of the transformants was evaluated and compared to that of the wild type in simple CBP systems using either corn cob or wheat bran as sole carbon sources. Both transformants produced approximately 60% more ethanol compared to the wild type on corn cob, while for wheat bran this picture was repeated for only one of them. This result is attributed to the high extracellular xylanase activities in the transformants’ fermentation broths that were maintained 2–2.5-fold higher compared to the wild type.

This paper describes an empirical study aiming to assess nursing students' perceptions on Electronic Health Record (EHR) concepts and their potential future attitude towards use. Based on the theoretical ground of Rogers' Innovation Diffusion Theory and other research works, a formulated model was empirically validated among ninety nursing undergraduates. Data analysis was based on partial least squares path modeling. Results highlighted the very strong significant effect of relative advantage and observability as well as the significant effect of perceived ease of use to attitude towards using EHR systems. The study findings are discussed along with limitations and future work in the current field.

This paper describes an empirical study aiming to assess nursing students' perceptions on Electronic Health Record (EHR) concepts and their potential future attitude towards use. Based on the theoretical ground of Rogers' Innovation Diffusion Theory and other research works, a formulated model was empirically validated among ninety nursing undergraduates. Data analysis was based on partial least squares path modeling. Results highlighted the very strong significant effect of relative advantage and observability as well as the significant effect of perceived ease of use to attitude towards using EHR systems. The study findings are discussed along with limitations and future work in the current field. © 2011 European Federation for Medical Informatics. All rights reserved.

Specific immunotherapy (SIT) is one of the treatments for allergic rhinitis. However, for allergists, nonspecialists, regulators, payers, and patients, there remain gaps in understanding the evaluation of randomized controlled trials (RCTs). Although treating the same diseases, RCTs in SIT and pharmacotherapy should be considered separately for several reasons, as developed in this study. These include the severity and persistence of allergic rhinitis in the patients enrolled in the study, the problem of the placebo, allergen exposure (in particular pollen and mite), the analysis and reporting of the study, the level of symptoms of placebo-treated patients, the clinical relevance of the efficacy of SIT, the need for a validated combined symptom-medication score, the differences between children and adults and pharmacoeconomic analyses. This statement reviews issues raised by the interpretation of RCTs in sublingual immunotherapy. It is not possible to directly extrapolate the rules or parameters used in medication RCTs to SIT. It also provides some suggestions for the research that will be needed. Interestingly, some of the research questions can be approached with the available data obtained from large RCTs.

We perform aperture photometry and profile fitting on 419 globular cluster (GC) candidates with mV <= 23 mag identified in Hubble Space Telescope/Advanced Camera for Surveys BVI imaging, and estimate the effective radii of the clusters. We identify 85 previously known spectroscopically confirmed clusters, and newly identify 136 objects as good cluster candidates within the 3σ color and size ranges defined by the spectroscopically confirmed clusters, yielding a total of 221 probable GCs. The luminosity function peak for the 221 probable GCs with estimated total dereddening applied is V ~ (20.26 ± 0.13) mag, corresponding to a distance of ~3.7 ± 0.3 Mpc. The blue and red GC candidates, and the metal-rich and metal-poor spectroscopically confirmed clusters, respectively, are similar in half-light radius. Red confirmed clusters are about 6% larger in median half-light radius than blue confirmed clusters, and red and blue good GC candidates are nearly identical in half-light radius. The total population of confirmed and "good" candidates shows an increase in half-light radius as a function of galactocentric distance. Based on observations with the Hubble Space Telescope obtained at the Space Telescope Science Institute, operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-26555. These observations are associated with Program GO-10250 and Program GO-10584.

Human Papilloma Virus (HPV) is becoming a menace worldwide, especially to the developing world, due to its involvement in a variety of malignancies, with cervical cancer being the most important and prevalent. There are many HPV types; HPV 16/18 are the most carcinogenic but few others are also characterized as high-risk (HR). They can cause a variety of low- or high-grade cellular abnormalities, most frequently detected in a routine Pap test. Most infections clear within 2 years, however, a minority persists and potentially could progress to cervical cancer. Molecular tests detecting HPV DNA, RNA or proteins are now being available either commercially or in-house developed. DNA detection is nowadays an established tool for diagnosis and monitoring of HPV-related disease, however, there is lack of a reference method and standardization with reference materials. The various available test formats create confusion on which molecular test to choose and what are its limitations. Therefore, the need for lab accreditation and participation in proficiency testing has to be stressed. Novel HPV biomarkers (RNA, protein etc.) are now intensively examined for their inclusion as adjunct tools. Recently, developed prophylactic vaccines for HPV 16/18 have already proven safe and efficient and raise high expectations for the complete eradication of these types in the future

The goal of this study is the analysis of heat waves and their impact on humans, using human biometeorological indices, which are based on the energy balance of the human body. The implications for humans are not only described through the intensity of the heat waves, but also through their duration over consecutive days. Both intensity and duration were analyzed for the Greater Athens Area during the period 1955 to 2001. The analysis was carried out using the daily physiologically equivalent temperature and the daily minimum air temperature. Based on these two parameters, the results showed an increase in the average duration of heat waves. Furthermore, the use of the Gaussian filter revealed the intra-annual variation of heat stress conditions and their relevance to humans. The results could be used for the management of the negative consequences of heat waves in cities suffering from environmental pollution and also for climate impact studies. © 2010 Springer-Verlag.

Context: Ovarian and adrenal hyperandrogenism characterize premenopausal women with polycystic ovary syndrome (PCOS). Androgens decline with age in healthy and PCOS women. Objective: The objective of the study was to investigate hyperandrogenism in PCOS after menopause. Design: This was a case-control, cross-sectional study. Setting: The study was conducted at a university hospital endocrinology unit. Patients: Twenty postmenopausal women with PCOS and 20 age- and body mass index-matched controls participated in the study. Interventions: Serum cortisol, 17-hydroxyprogesterone (17-OHP), Δ4- androstenedione (Δ4A), dehydroepiandrosterone sulfate (DHEAS), total testosterone (T), and free androgen index (FAI) levels were measured at baseline, after ACTH stimulation, and after 3-d dexamethasone suppression. The ACTH and cortisol levels were measured during the CRH test. Main Outcome Measures: Androgen profile at baseline, after ACTH stimulation, and 3-d dexamethasone suppression tests were the main outcome measures. Results: Postmenopausal PCOS women had higher 17-OHP, Δ4A, DHEAS, total T, FAI (P < 0.05) and lower SHBG (P<0.05) baseline levels than control women. ACTH and cortisol responses during the CRH test were similar in the two groups. After ACTH stimulation, Δ4A, DHEAS, and total T levels were equally increased in both groups. After dexamethasone suppression, LH levels did not change in either group; 17-OHP-, Δ4A-, and FAI-suppressed levels remained higher in PCOS than in control women (P < 0.05), whereas total T and DHEAS levels were suppressed to similar values in both groups. Conclusions: In postmenopausal PCOS women, ACTH and cortisol responses to CRH are normal. Androgen levels at baseline are higher in PCOS than control women and remain increased after ACTH stimulation. The dexamethasone suppression results in postmenopausal PCOS women suggest that DHEAS and total T are partially of adrenal origin. Although the ovarian contribution was not fully assessed, increased Δ4A production suggests that the ovary also contributes to hyperandrogenism in postmenopausal PCOS women. In conclusion, postmenopausal PCOS women are exposed to higher adrenal and ovarian androgen levels than non-PCOS women. Copyright © 2011 by The Endocrine Society.

We recently described paratarg-7 (P-7), a protein of unknown function, as the target of 15% of immunoglobulin A (IgA) and IgG paraproteins in monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma. To determine the frequency of P-7 as a paraprotein target in IgM-MGUS and Waldenström macroglobulinemia (WM), sera from patients with IgM-MGUS/WM were tested for reactivity with recombinant P-7 by enzyme-linked immunoabsorbent assay. The specificity of the paraprotein-mediated reaction was shown by absorption studies and cloning of the respective B-cell receptor. The paraproteins of 18 (9 WM and 9 IgM-MGUS) of 161 patients (11%) reacted with P-7. Isoelectric focusing and phosphatase treatment showed that P-7 was hyperphosphorylated (pP-7) in all patients with an anti - P-7-specific IgM paraprotein tested. Because only 4 of 200 healthy controls (2%) were carriers of pP-7, pP-7 carrier state is associated with a significantly increased risk (odds ratio = 6.2; P = .001) for developing IgM-MGUS/MW. Family analyses showed that the pP-7 carrier state is inherited as a dominant trait. After IgA/IgGMGUS and multiple myeloma, IgMMGUS/WM is the second neoplasia associated with pP-7 carrier state. The dominant inheritance of pP-7 explains cases of familial IgM-MGUS/WM and enables the identification of family members at increased risk. © 2011 by The American Society of Hematology.

Development and homeostasis of multicellular organisms relies on an intricate balance between cell proliferation and differentiation. Geminin regulates the cell cycle by directly binding and inhibiting the DNA replication licensing factor Cdt1. Geminin also interacts with transcriptional regulators of differentiation and chromatin remodelling factors, and its balanced interactions are implicated in proliferation-differentiation decisions during development. Here, we describe Idas (Idas being a cousin of the Gemini in Ancient Greek Mythology), a previously uncharacterised coiled-coil protein related to Geminin. We show that human Idas localizes to the nucleus, forms a complex with Geminin both in cells and in vitro through coiled-coil mediated interactions, and can change Geminin subcellular localization. Idas does not associate with Cdt1 and prevents Geminin from binding to Cdt1 in vitro. Idas depletion from cells affects cell cycle progression; cells accumulate in S phase and are unable to efficiently progress to mitosis. Idas protein levels decrease in anaphase, whereas its overexpression causes mitotic defects. During development, we show that Idas exhibits high level expression in the choroid plexus and the cortical hem of the mouse telencephalon. Our data highlight Idas as a novel Geminin binding partner, implicated in cell cycle progression, and a putative regulator of proliferation-differentiation decisions during development.

Aims: IKT 16 is an X-ray and radio-faint supernova remnant (SNR) in the Small Magellanic Cloud (SMC). A previous X-ray study of this SNR found a hard X-ray source near its centre. Using all available archival and proprietary XMM-Newton data, alongside new multi-frequency radio-continuum surveys and optical observations at Hα and forbidden [SII] and [OIII] lines, we aim to constrain the properties of the SNR and discover the nature of the hard source within. Methods: We combine XMM-Newton datasets to produce the highest quality X-ray image of IKT 16 to date. We use this, in combination with radio and optical images, to conduct a multi-wavelength morphological analysis of the remnant. We extract separate spectra from the SNR and the bright source near its centre, and conduct spectral fitting of both regions. Results: We find IKT 16 to have a radius of 37 ± 3 pc, with the bright source located 8 ± 2 pc from the centre. This is the largest known SNR in the SMC. The large size of the remnant suggests it is likely in the Sedov-adiabatic phase of evolution. Using a Sedov model to fit the SNR spectrum, we find an electron temperature kT of 1.03 ± 0.12 keV and an age of ≈14700 yr. The absorption found requires the remnant to be located deep within the SMC. The bright source is fit with a power law with index Γ = 1.58 ± 0.07, and is associated with diffuse radio emission extending towards the centre of the SNR. We argue that this source is likely to be the neutron star remnant of the supernova explosion, and infer its transverse kick velocity to be 580 ± 100 km s-1. The X-ray and radio properties of this source strongly favour a pulsar wind nebula (PWN) origin. Based on observations obtained with XMM-Newton, an ESA science mission with instruments and contributions directly funded by ESA Member States and NASA.

We have undertaken a meta-analysis of the English literature, to assess the component alignment outcomes after imageless computer assisted (CAOS) total knee arthroplasty (TKA) versus conventional TKA. We reviewed 23 publications that met the inclusion criteria. Results were summarised via a Bayesian hierarchical random effects meta-analysis model. Separate analyses were conducted for prospective randomised trials alone, as well as for all randomised and observational studies. In 20 papers (4,199 TKAs) we found a reduction in outliers rate of approximately 80% in limb mechanical axis when operated with the CAOS. For the coronal femoral and tibial implants positions, the analysis included 3,058 TKAs. The analysis for the femoral implant showed a reduction in outliers rate of approximately 87% and for the tibial implant a reduction in outliers rate of approximately 80%. Imageless navigation when performing TKA improves component orientation and postoperative limb alignment. The clinical significance of these findings though has to be proven in the future.

Dans cet article, nous présentons la revue Le Tour du monde : journal des voyages, qui a été publiée par Édouard Charton, et nous nous attardons sur l’importance de son illustration. Plus précisément nous traitons de la représentation de l’Autre dans les récits des voyages, qui étaient publiés entre 1860 et le début du XXe sièle. Constituant un corpus hétérogène, les articles rédigés par des auteurs comme Henri Cammas, Ernest Chantre, Bellonie Chantre, Louis Lortet, Charles Grad et Paul Merruaut et illustrés par des artistes célèbres comme Édouard Riou, Henriette Browne et Adalabert de Beaumont, communiquent des informations importantes sur les populations des endroits parcourus. Quoique les auteurs de la TdM, qui avaient des relations superficielles avec les populations des contrées parcourues, n’aient pas évité une représentation stéréotypée de l’Autre, leurs descriptions et leurs commentaires sur l’apparence extérieure ainsi que leurs références à la religion, au dogme, aux moeurs et aux coutumes des habitants ont reconstitué une image vivante et variée de l’Orient. Notre étude s’attarde également sur l’illustration des articles, qui, appuyée sur un matiériel iconographique varié (dessins, photographies), fournit des informations précieuses sur les sujets traités.

Lapsley’s (1993) “New Look” model for the interpretation of adolescent egocentrism, as an alternative to the classic cognitive one formulated by Elkind (1967), was tested in this study. According to the “New Look” model, the two manifestations of adolescent egocentrism – the imaginary audience and the personal fable – are adaptive coping mechanisms used by adolescents in their attempt to deal with the stressful developmental aim of separation-individuation. Two-hundred ninety seven adolescents 11-18 years’ old completed the Imaginary Audience Scale (Elkind & Bowen, 1979), the New Imaginary Audience Scale (Lapsley, Fitzgerald, Rice, & Jackson, 1989), the Personal Fable Scale (Elkind, personal communication, August 10, 1993), the New Personal Fable Scale (Lapsley et al., 1989), and the Separation-Individuation Test of Adolescence (Levine, Green, & Millon, 1986; Levine & Saintonge, 1993). The “New Look” model was generally supported by the data. The various dimensions of separation were significantly associated with the imaginary audience, whereas the dimensions of individuation had stronger links with the personal fable. In addition, some associations were found between the imaginary audience and individuation, as well as between the personal fable and separation. Consistent age and gender differences in the variables studied were found. Results are discussed in the framework of the literature on adolescent egocentrism and on parent-adolescent relations.

A prospective epidemiologic surveillance of hospitalizations associated with influenza was conducted in order to calculate population-based hospitalization rates. Eligible children were 6 months to 13 years of age and were admitted to one of the two large children's hospitals in the Athens area during two influenza seasons. Nasopharyngeal aspirates were tested for influenza by a polymerase reaction assay. Influenza accounted for 9.9-11.8% of all admissions during the influenza season and the overall annual rate of hospitalizations was 13.6-16.8 cases per 10,000 children being highest for children under 5 years of age (26-31.2/10,000 children). Febrile seizures and acute otitis media were the two most common complications associated with influenza and antibiotics were administered to 61% of flu positive patients. Influenza is associated with high hospitalization rates among young children and these may be substantially reduced with the introduction of routine immunization.

This analysis assessed the effect of lenalidomide on progression-free survival (PFS). Patients with relapsed or refractory multiple myeloma (RRMM) who received lenalidomide plus dexamethasone in the MM-009 and MM-010 trials were pooled and those who had not progressed and were still receiving lenalidomide at 12 months were included. The median follow-up of surviving patients was 48 months. Of 353 patients who received lenalidomide plus dexamethasone, 116 (33%) had not progressed. Overall, 52 patients (45%) had no dose reductions, 25 (22%) had dose reductions ≥12 months and 39 (34%) had dose reductions before 12 months. Patients who had dose reductions ≥12 months had a significantly longer median PFS than those who had reductions before 12 months (P=0.007) or no dose reductions (P=0.039) (not reached vs 28.0 vs 36.8 months, respectively). In a multivariate Cox regression model, dose reduction ≥12 months was an independent predictor of improved PFS (hazard ratio, 0.47; 95% confidence interval, 0.23-0.98) after adjusting for patient characteristics. The data suggest that to achieve maximum PFS benefit, patients with RRMM should be treated for ≥12 months with full-dose lenalidomide plus dexamethasone. Thereafter, patients may benefit from lower-dose continued therapy; prospective studies are needed to confirm these findings. © 2011 Macmillan Publishers Limited All rights reserved.

BACKGROUND: The heptavalent pneumococcal conjugate vaccine (PCV7) has a considerable effect on the epidemiology of pneumococcal disease. The aim of this observational hospital-based study was to examine the effect of the PCV7 (introduced in our settings in 2004) on the epidemiology of spontaneously draining acute otitis media. METHODS: Results of all middle ear fluid cultures (n = 3446) obtained from children with acute otitis media complicated with otorrhea before the introduction of immunization (between 2000 and 2003) were compared with those (n = 2134) obtained during a similar post-PCV7 period (between 2005 and 2008). Results of cultures obtained between 2006 and 2008 were examined prospectively, whereas those obtained in previous years were retrospectively reviewed. RESULTS: Following PCV7 immunization, the rates of otorrhea visits per 10,000 emergency department visits decreased by 38% from 133 to 83 (95% confidence interval of the difference, 42-53; P < 0.001), mainly as a result of the decrease in the incidence of pneumococcal disease (48% decrease-25 vs. 13 per 10,000 emergency department visits; P < 0.001). Otorrhea due to Haemophilus influenzae decreased by 20% (20-16 per 10,000 visits; P < 0.001). Serotype 19A accounted for 1 of 47 (2%) pneumococcal strains in 2006, for 5 of 34 (15%) in 2007, and for 13 of 53 (25%) in 2008 (P for trend: 0.001). In the postvaccine years, penicillin-resistant pneumococcal strains (minimum inhibitory concentration >/= 2 mug/mL) increased from 4% to 13% (P < 0.001). However, the proportion of pneumococci resistant to macrolides decreased (44% vs. 35%; P = 0.01). CONCLUSIONS: After the introduction of immunization, otorrhea incidents decreased considerably, mainly because of the decrease in pneumococcal disease. H. influenzae is now the predominant organism. Serotype 19A has increased significantly and is the most common nonvaccine pneumococcal serotype. Penicillin resistance has increased in recent years.

Aims: We investigate photon quenching in compact non-thermal sources. This involves photon-photon annihilation and lepton synchrotron radiation in a network that can become non-linear. As a result the γ-ray luminosity of a source cannot exceed a critical limit that depends only on the radius of the source and on the magnetic field. Methods: We perform analytic and numerical calculations that verify previous results and extend them so that the basic properties of photon quenching are investigated. Results: We apply the above to the 2006 TeV observations of quasar 3C 279 and obtain the parameter space of allowed values for the radius of the emitting source, its magnetic field strength and the Doppler factor of the flow. We argue that the TeV observations favour either a modest Doppler factor and a low magnetic field or a high Doppler factor and a high magnetic field.

Aims: We investigate photon quenching in compact non-thermal sources. This involves photon-photon annihilation and lepton synchrotron radiation in a network that can become non-linear. As a result the γ-ray luminosity of a source cannot exceed a critical limit that depends only on the radius of the source and on the magnetic field. Methods: We perform analytic and numerical calculations that verify previous results and extend them so that the basic properties of photon quenching are investigated. Results: We apply the above to the 2006 TeV observations of quasar 3C 279 and obtain the parameter space of allowed values for the radius of the emitting source, its magnetic field strength and the Doppler factor of the flow. We argue that the TeV observations favour either a modest Doppler factor and a low magnetic field or a high Doppler factor and a high magnetic field.

The coexistence of cerebral infarcts and Alzheimer's disease (AD) is common, but the influence of symptomatic cerebral infarcts on cognition is uncertain in AD. We hypothesize that symptomatic cerebral infarcts may provide an additive cognitive factor contributing to dementia in the AD population. We studied 1,001 clinically probable or possible AD patients in the Alzheimer Disease Research Center (ADRC) database. Linear regression was used to evaluate for an association between symptomatic cerebral infarcts and memory, language, executive function, abstract reasoning, and visuospatial performance, separately. Models were adjusted for covariates including age, gender, education, ethnicity, hypertension, diabetes mellitus, heart disease, clinical dementia rating, the presence of silent cerebral infarcts, and multiplicity or location of infarcts. Clinical history of stroke was present in 107 patients, radiological infarcts in 308 patients, and 68 patients with both were considered to have symptomatic infarcts. Adjusting for all covariates, AD patients with symptomatic infarcts had more impairment of executive function (P < 0.05). The influence of cerebral infarcts is neither general nor diffuse, and the presence of clinical history may have a more important influence on executive performance in AD.

The complexes [Ru(Tai)H(PPh3)2] (4) [Tai = HB(7-azaindolyl)3] and [Ru(ArBai)H(PPh3) 2] [ArBai = Ar(H)B(7-azaindolyl)2; Ar = phenyl (5), mesityl (6) and 2-naphthyl (7)] have been prepared and fully characterised. Structural characterisation of complexes 4, 5 and 7 confirmed the expected κ3-NNH coordination mode of the azaindolyl-based ligands. In all complexes, the borohydride unit is located trans to the hydrido ligand, and the two triphenylphosphane ligands occupy sites trans to the two nitrogen donors. The strong Ru⋯H-B interaction means that the third substituent at the boron atom is held in close proximity to the ruthenium centre. In the case of complex 7, rotation of the naphthyl group about the boron centre is hindered by the triphenylphosphane substituents. The synthesis of a number of ruthenium hydride complexes containing azaindole-based scorpionate ligands is reportedherein. The scorpionate ligands bind to the metal centre with κ3-NNH coordination modes. The strong borohydride⋯metal interaction pulls the additional substituent at the boron atom towards the bulky triphenylphosphane ligands. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Osteoarthritis (OA) is a slowly progressive degenerative joint disease that is associated with joint space narrowing, osteophyte formation and subchondral sclerosis. Despite extensive effort actual breakthroughs in the field of genetic or biochemical biomarkers of OA are limited. As secretory apolipoprotein J/clusterin (sCLU) has been implicated in both inflammatory and apoptotic molecular processes which contribute to the OA phenotype, the sCLU concentration in human serum and synovial fluid during advanced primary knee and hip OA was analysed. Elevated sCLU protein levels were shown in these two biological fluids. sCLU mRNA expression was also studied in normal cartilage and in advanced primary knee and hip OA samples. A significant up-regulation of sCLU mRNA expression (∼25-fold) was found in samples collected from the tibial bone that was osteotomized during total knee arthroplasty in patients with primary knee OA, as compared to healthy tissue samples collected from the femoral head of macroscopically normal cartilage during the surgical treatment of subcapital fractures. By studying sCLU mRNA expression levels in samples collected during total hip arthroplasty in patients with advanced primary hip OA, an additional up-regulation of the sCLU mRNA expression (∼4-fold), as compared to advanced primary knee OA, was found. Taken together, these observations indicate that the sCLU protein or mRNA expression level may be of a significant diagnostic and/or prognostic value during OA progression.

Dilated cardiomyopathy (DCM) is associated with increased inflammatory response reflected among other markers in high-sensitivity C-reactive protein (hsCRP) and soluble interleukin-2 receptor (sIL-2R) levels. We examined prospectively 60 consecutive patients with DCM. Of them, 30 were dyslipidemic (group I) and 30 normolipidemic (group II). Group I patients were randomized to either simvastatin therapy (20 mg/day, group Ia, n = 15) or hypolipidemic diet therapy (group Ib, n = 15). Patients were re-evaluated 6 months later. High-sensitivity C-reactive protein and sIL-2R levels were significantly higher in group I compared with group II patients (19.5 +/- 3.4 vs 3.03 +/- 3.5 mg/L, P = .01, 1137 +/- 441 vs 599 +/- 235 pg/mL, P = .001, respectively). There was a significant correlation between sIL-2R and hsCRP levels in dyslipidemic patients but not in normolipidemic patients. Significant reduction of hsCRP and sIL-2R levels was observed only in group Ia patients. Patients with DCM having dyslipidemia have increased inflammatory response, which is reduced after 6 months of statin therapy

In 203 consecutive unselected patients with symptomatic MM who received upfront treatment with novel agents, high levels of serum LDH were independently associated with poor survival and could identify subgroups of patients within ISS-2 and ISS-3 with even worse outcome. Evaluating serum LDH levels is a simple, inexpensive, and readily available procedure that could be considered among the variables that define very-high-risk MM. Background: In patients who have symptomatic multiple myeloma (MM), a high serum lactate dehydrogenase (LDH) level is associated with features of advanced disease, adds prognostic value to the international staging system (ISS) and predicts for inferior survival. However, it has not been clearly defined what the impact of this abnormality is for patients treated upfront with novel agent-based regimens. Patients and Methods: To address this issue we analyzed 203 consecutive unselected patients with symptomatic MM who received upfront treatment with novel agents in a single center. Results: The median overall survival for patients with normal LDH was 54 months but in patients with increased LDH levels it was 21 months (P =.003), whereas increased serum LDH was associated with a higher probability of early death. Multivariate analysis confirmed that an increased LDH level is independently associated with poor survival. Furthermore, increased LDH levels could identify subgroups of patients within ISS-2 and ISS-3 with even worse outcome. Conclusion: We conclude that serum LDH is a simple, inexpensive, and readily available blood test that may be included among the variables that define very-high-risk MM. © 2011 Elsevier Inc. All rights reserved.

OBJECTIVES: The study aimed to evaluate a wide range of apoptotic markers in the vein wall of patients with superficial chronic venous disease (SCVD) compared with normal veins. DESIGN: This was an observational study. METHODS: Vein specimens were obtained from 19 patients suffering from SCVD. From each patient, a specimen of the proximal part of the great saphenous vein (GSV), a specimen of the distal part of the vein and a specimen of a varicose tributary were obtained. Immunohistochemical analysis was used to localise the expression of BAX, p53, Caspase 3, BCL-2, BCL-6, BCL-xs, BCL-xl and Ki-67. Vein specimens from 10 healthy GSVs were used as controls. RESULTS: Saphenous vein specimens from patients with SCVD showed increased BAX, Caspase 3, BCL-xl and BCL-xs (p < 0.01 for all) and Ki-67 (p = 0.02) compared with healthy GSVs. In the venous disease group, GSV specimens from the distal ankle area showed increased BAX (p < 0.01) and BCL-xs (p = 0.031) compared with varicose tributaries specimens, which subsequently showed increased BAX (p = 0.044), Caspase 3 (p = 0.028) and BCL-xs (p = 0.037) compared with specimens from the proximal GSV. In addition, in the venous disease group, specimens from distal GSV showed increased BAX (p < 0.01), Caspase 3 (p = 0.019) and BCL-xs (p = 0.014) compared with the proximal GSV. CONCLUSION: Varicose veins exhibit increased apoptotic activity, by means of increased BAX, Caspase 3, BCL-xl and BCL-xs, compared with normal veins. Patients with varicose vein disease show increased apoptosis in the distal saphenous trunk compared with the proximal saphenous trunk, suggesting an association between chronic venous hypertension and apoptosis.

The purpose of this study was to evaluate the postactivation potentiation (PAP) effect of isometric and plyometric contractions on explosive performance of the upper and the lower limbs in male and female elite athletes. Thirteen male and ten female international level fencers performed four protocols of either isometric (3 sets of 3 sec) or plyometric (3 sets of 5 repetitions) bench and leg press, in a within subject randomized design. Before and immediately after the PAP treatment and following 4, 8, 12 min, explosive performance was measured by performing a countermovement jump (CMJ) or a bench press throw. Statistical analysis revealed significant time effect for peak leg power during the CMJ (p < 0.001) only for men, with values after the isometric PAP treatment being lower than baseline at the 8 and 12 min time points (by 7.5% (CI95% = 3.9-11.2%) and 8.7% (CI95% = 6.0-11.5%, respectively), while after the plyometric PAP treatment peak leg power remained unchanged. A significant negative correlation was found between leg strength (as expressed by 1-RM leg press performance) and the change in peak leg power between baseline and after 12 min of recovery only in male fencers (r = -0.55, p < 0.05), suggesting that stronger individuals may show a greater decrease in peak leg power. Based on the above results we conclude that lower body power performance in international level fencers may be negatively affected after isometric contractions and thus they should be advised against using isometric exercises to induce PAP with the protocol prescribed in the present study. Furthermore, gender and strength level must be considered in the practical application of PAP. © Journal of Sports Science and Medicine.

The purpose of this study was to evaluate the postactivation potentiation (PAP) effect of isometric and plyometric contractions on explosive performance of the upper and the lower limbs in male and female elite athletes. Thirteen male and ten female international level fencers performed four protocols of either isometric (3 sets of 3 sec) or plyometric (3 sets of 5 repetitions) bench and leg press, in a within subject randomized design. Before and immediately after the PAP treatment and following 4, 8, 12 min, explosive performance was measured by performing a countermovement jump (CMJ) or a bench press throw. Statistical analysis revealed significant time effect for peak leg power during the CMJ (p < 0.001) only for men, with values after the isometric PAP treatment being lower than baseline at the 8 and 12 min time points (by 7.5% (CI95% = 3.9-11.2%) and 8.7% (CI95% = 6.0-11.5%, respectively), while after the plyometric PAP treatment peak leg power remained unchanged. A significant negative correlation was found between leg strength (as expressed by 1-RM leg press performance) and the change in peak leg power between baseline and after 12 min of recovery only in male fencers (r = -0.55, p < 0.05), suggesting that stronger individuals may show a greater decrease in peak leg power. Based on the above results we conclude that lower body power performance in international level fencers may be negatively affected after isometric contractions and thus they should be advised against using isometric exercises to induce PAP with the protocol prescribed in the present study. Furthermore, gender and strength level must be considered in the practical application of PAP. © Journal of Sports Science and Medicine.

The purpose of this study was to evaluate the postactivation potentiation (PAP) effect of isometric and plyometric contractions on explosive performance of the upper and the lower limbs in male and female elite athletes. Thirteen male and ten female international level fencers performed four protocols of either isometric (3 sets of 3 sec) or plyometric (3 sets of 5 repetitions) bench and leg press, in a within subject randomized design. Before and immediately after the PAP treatment and following 4, 8, 12 min, explosive performance was measured by performing a countermovement jump (CMJ) or a bench press throw. Statistical analysis revealed significant time effect for peak leg power during the CMJ (p < 0.001) only for men, with values after the isometric PAP treatment being lower than baseline at the 8 and 12 min time points (by 7.5% (CI95% = 3.9-11.2%) and 8.7% (CI95% = 6.0-11.5%, respectively), while after the plyometric PAP treatment peak leg power remained unchanged. A significant negative correlation was found between leg strength (as expressed by 1-RM leg press performance) and the change in peak leg power between baseline and after 12 min of recovery only in male fencers (r = -0.55, p < 0.05), suggesting that stronger individuals may show a greater decrease in peak leg power. Based on the above results we conclude that lower body power performance in international level fencers may be negatively affected after isometric contractions and thus they should be advised against using isometric exercises to induce PAP with the protocol prescribed in the present study. Furthermore, gender and strength level must be considered in the practical application of PAP. © Journal of Sports Science and Medicine.

Group IIA secreted phospholipase A2 (GIIA sPLA2) is a member of the mammalian sPLA2 enzyme family and is associated with various inflammatory conditions. In this study, the synthesis of 2-oxoamides based on α-amino acids and the in vitro evaluation against three secreted sPLA2s (GIIA, GV and GX) are described. The long chain 2-oxoamide GK126 based on the amino acid (S)-leucine displayed inhibition of human and mouse GIIA sPLA2s (IC50 300 nM and 180 nM, respectively). It also inhibited human GV sPLA2 with similar potency, while it did not inhibit human GX sPLA2. The elucidation of the stereoelectronic characteristics that affect the in vitro activity of these compounds was achieved by using a combination of simulated annealing to sample low-energy conformations before the docking procedure, and molecular docking calculations.

Visible light-activated sulfur doped TiO2 nanocrystalline films were synthesized by a sol-gel method based on the self-assembly technique with nonionic surfactant to control nanostructure and an inorganic sulfur source (i.e., H2SO4). The films were characterized by UV-vis diffuse reflectance, XRD, TEM, Raman, AFM, ESEM, XPS, FT-IR, EDX, EPR and porosimetry. The results showed that the physicochemical properties of the films, such as BET surface area, porosity, crystallite size and pore size distribution could be controlled by the calcination temperature. The highest surface area, smallest crystallite size and narrow pore size distribution were obtained for sulfur doped TiO2 films calcined at 350°C, which exhibit very smooth surface with minimal roughness (<1nm). The optical absorption edge of sulfur doped TiO2 was red shifted with indirect bandgap energy of 2.94eV. Sulfur species distributed uniformly throughout the films were identified both as S2- ions related to anionic substitutional doping of TiO2 as well as S6+/S4+ cations, attributed mainly to the presence of surface sulfate groups. EPR measurements revealed a sharp signal at g=2.004, whose intensity correlated with the sulfur content and most importantly was markedly enhanced under visible light irradiation, implying the formation of localized energy states in the TiO2 band gap due to anion doping and/or oxygen vacancies. In terms of photocatalytic activity, films calcined at 350°C were the most effective for the degradation of hepatotoxin microcystin-LR (MC-LR) under visible light irradiation, while films calcined at 400°C and 500°C degraded MC-LR to a lower extent, following the evolution of the sulfur content with calcination temperature. The photocatalytic activity of the sulfur doped TiO2 film was stable during three consecutive experiments under visible light irradiation, confirming the mechanical stability and reusability of the doped nanostructured thin film photocatalysts. © 2011 Elsevier B.V.

The mechanisms governing the induction of peripheral tolerance as a result of specific immunotherapy are far from being clearly characterized. In the last 15 years, a number of studies have highlighted the tolerogenic role of regulatory T cells, blocking antibodies and anti-inflammatory cytokines such as IL-10 and TGF-β; however, the best part of our knowledge is mostly limited to mechanisms underlying the maintenance phase. By contrast, little is known regarding the very early effects seen in rush and ultrarush immunotherapy protocols. In this article, Bussmann et al. provide evidence on the possible role, first, of inhibitory receptors of the leukocyte immunoglobulin-like receptor family and, second, of the upregulation of indoleamine 2,3-dioxygenase and subsequent tryptophan starvation on the induction of specific tolerance within a few hours after the initial doses. They also suggest that the observed changes reflect the activation of protective mechanisms, which we are just beginning to understand.

The skeletal and immune systems have a complex relationship. Both systems are intimately coupled, with osteoclastogenesis and hematopoiesis occurring in the bone marrow. Bone and immune cells also share common hematopoietic precursors. Furthermore, the skeletal and immune systems share various cytokines, receptors, and transcription factors that regulate signal transduction pathways involved in osteoclastogenesis and immune system activation, including the receptor activator of nuclear factor-κΒ ligand/receptor activator of nuclear factor-κΒ/osteoprotegerin (RANKL-RANK-OPG) pathway. Cancer cells can disrupt both the skeletal and immune systems. Interaction between cancer and bone cells results in a vicious cycle of bone destruction and cancer growth. Bone remodeling generates a growth-factor-rich environment that attracts cancer cells and promotes their proliferation. In turn, cancer cells stimulate osteoclast formation and activity, resulting in additional bone resorption that further stimulates cancer cell growth. Currently available bone-targeted therapies may also modulate the immune system. Bisphosphonates such as zoledronic acid exert stimulating effects on the immune system, resulting in possible anticancer activity against malignant cells. Denosumab, an anti-RANKL monoclonal antibody with proven antiosteoclast activity, may suppress immune responses. This may result in the reported association with an increased risk of neoplasms, as well as serious skin and other infections as reported in some studies, mainly in the postmenopausal setting. When assessing bone-targeted therapies, it is important to consider the shared signaling pathways between bone and the immune system, as well as the clinical risk:benefit ratio. © 2011 Springer-Verlag.

Objectives To determine whether intermittent docetaxel might control disease while limiting the toxicity and improving the quality-of-life parameters in patients with advanced, castrate-resistant prostate cancer. Intermittent docetaxel represents an appealing therapeutic approach. Methods We reviewed the records of 35 patients with chemotherapy-naive castrate-resistant prostate cancer who had received docetaxel 45 mg/m2 every 2 weeks, with oral prednisone 5 mg twice daily. Treatment was held when the patients had reached a >50% prostate-specific antigen reduction from baseline that was confirmed by a second measurement 4 weeks later, in the absence of disease progression. Docetaxel was resumed at a >25% prostate-specific antigen increase from the nadir level, also confirmed by a second measurement 4 weeks later, or in cases of documented disease progression. Results Of the 35 patients, 18 (51.42%) had entered the first chemotherapy-free interval (CFI) after a median of 6 infusions (range 2-12), 6 patients had entered a second CFI after a median of 4 months (range 2-12), and 1 patient, a third CFI at the last follow-up point. The median interval "off chemotherapy" was 4.5 months (range 1-16) for the first CFI. Two patients discontinued docetaxel because of Grade 4 nonhematologic toxicity. The median interval to treatment failure was 8.1 months (95% confidence interval 5.1-12.2) for the entire cohort and 12.2 months (95% confidence interval 8.3-25+) for the patients who had entered the first CFI. Conclusions The results of our study have shown that intermittent docetaxel is a clinically active and likely more tolerable and less costly therapeutic strategy for patients with castrate-resistant prostate cancer than continuous administration. Additional validation of this approach is warranted. © 2011 Elsevier Inc.

The role of high-dose therapy followed by autologous stem cell transplantation (ASCT) in the treatment of multiple myeloma (MM) continues to evolve in the novel agent era. The choice of induction therapy has moved from conventional chemotherapy to newer regimens incorporating the immunomodulatory derivatives thalidomide or lenalidomide and the proteasome inhibitor bortezomib. These drugs combine well with traditional therapies and with one another to form various doublet, triplet, and quadruplet regimens. Up-front use of these induction treatments, in particular 3-drug combinations, has affected unprecedented rates of complete response that rival those previously seen with conventional chemotherapy and subsequent ASCT. Autotransplantation applied after novel-agent-based induction regimens provides further improvement in the depth of response, a gain that translates into extended progression-free survival and, potentially, overall survival. High activity shown by immunomodulatory derivatives and bortezomib before ASCT has recently led to their use as consolidation and maintenance therapies after autotransplantation. Novel agents and ASCT are complementary treatment strategies for MM. This article reviews the current literature and provides important perspectives and guidance on the major issues surrounding the optimal current management of younger, transplantation-eligible MM patients. © 2011 by The American Society of Hematology.

The aim of this double-blind, randomized control trial was to compare the effectiveness of intra-articular ropivacaine alone or with morphine or ketoprofen for controlling pain after arthroscopic knee surgery. One hundred fifty-six patients scheduled for elective knee arthroscopy were recruited. All patients received general anesthesia and were randomly assigned to 4 groups to receive intra-articular ropivacaine 40 mg (group R), ropivacaine 24 mg plus morphine 8 mg (group R+M), ropivacaine 36 mg plus ketoprofen 100 mg (group R+K), or normal saline (group N/S). Pain, sedation, orientation, nausea, vomiting, and urine retention were recorded at 0, 1, 2, 4, 8, 12, and 24 hours postoperatively. Pain was evaluated by a 10-cm visual analog scale (VAS). When the pain was >2, a suppository of 400 mg paracetamol plus 10 mg codeine plus 50 mg caffeine was given. Results showed that at 4 hours postoperatively, pain differed significantly among the 4 groups (P<.001), with less pain recorded in the R+M group. Similarly, the number of suppositories administered postoperatively to the R+M group was significantly less (P<.001) vs the other groups. Patients who received ropivacaine and morphine or normal saline had a higher incidence of nausea and vomiting vs the other groups (P=.001 and P=.036, respectively). The combination of intra-articular ropivacaine and morphine is associated with less pain after knee arthroscopy during early recovery but with a higher incidence of nausea and vomiting. However, the addition of ketoprofen to ropivacaine provides relatively satisfactory pain relief, but with fewer side effects compared to morphine.

Perioperative use of a cell saver device can serve as a cost-beneficial alternative to the transfusion method, especially in countries where the cost of a single unit of blood is high. The purpose of this study, conducted in a Greek hospital, was to calculate the cost benefit of using a cell saver device to salvage intraoperative blood during open surgical abdominal aortic aneurysm repair or open aortofemoral bypass for occlusive disease. This retrospective study measured the amounts of salvaged blood and reinfused blood encountered during the procedure and then calculated the cost benefit of cell saver use. With the cost of a unit of blood purchased in Greece about €450 ($585), the blood units salvaged and reinfused were calculated at a mean cost benefit of €754 ($980) per case.

We study theoretically the conditions under which optical bistability is achievable in a two-subband system in a semiconductor quantum well. We consider the interaction of the two-subband system with a continuous wave electromagnetic field, which induces intersubband transitions. For the description of the system dynamics we use the effective nonlinear density matrix equations. We solve these equations analytically, in the steady state, for a GaAs/AlGaAs quantum well structure. For several combinations of the values of the parameters three real solutions of the population inversion arise and the phenomenon of optical bistability prevails.

Objectives To identify the intrinsic risk factors of non-contact strains in the hamstrings and quadriceps muscles of professional soccer players via a cohort prospective design. Methods A total of 100 professional soccer players (aged 19.4–27.8 years) from four professional teams underwent a composite musculoskeletal assessment at preseason. Intrinsic risk factors included dichotomies of asymmetries in muscle strength, flexibility, proprioception, anthropometry and knee joint stability, and of previous injuries. Muscle strains were prospectively monitored during the subsequent season using questionnaires. The data were analysed via binary logistic regression.Results Thirty-eight percent of the players sustained one or more lower-extremity muscle strains. Sixteen (42.1 %) and seven (18.4 %) of them were clinically diagnosed as having non-contact muscle strains at their hamstrings and quadriceps, respectively. Players with eccentric hamstring strength asymmetries (OR=3.88; 95% CI 1.13 to 13.23), functional leg length asymmetries (OR=3.80; 95% CI 1.08 to 13.33) and no previous hamstrings injuries (OR=0.15; 95% CI 0.029 to 0.79) were at greater risk of sustaining a hamstring muscle strain. Players with eccentric strength (OR=5.01; 95% CI 0.92 to 27.14) and flexibility asymmetries (OR=4.98; 95% CI 0.78 to 31.80) in their quadriceps as well as heavier (OR=10.70; 95% CI 0.73 to 156.37) and shorter players (OR=0.08; 95% CI 0.00 to 1.35) were at greater risk of sustaining a strain in this muscle group. Conclusions Professional soccer players with functional asymmetries possess a higher risk of sustaining hamstring strains. Previous injury seems not to constitute a risk factor. The systematic isokinetic evaluation of the lower extremities during the preseason period can provide therapists and trainers with valuable data regarding the predictive elements of non-contact hamstring strains in professional soccer players.

The assessment of an aquifers’ vulnerability to pollution is of great importance, and can be used as a tool to augment planning, effective protection and management of groundwater resources’ quality, especially in the case of karstic aquifers. The present study aims to assess the intrinsic vulnerability of a karstic groundwater system, with the use of a modified version of the PI method. The assessments are functional to the effectiveness of the protective cover, as well as to the degree to which the protective cover is bypassed due to flow conditions. The used data was obtained by field work, empirical and semi-quantitative approaches regarding lithology, fissuring and karstification of bedrock, soil characteristics, hydrology, hydrogeology, topography and vegetation. The combinational effect of the above parameters, as processed with the aid of a GIS system, yielded the final calculation of the protection factor (π) and subsequently the vulnerability of the aquifer to pollution.

The discovery of potential microarray markers, which will expedite molecular diagnosis/prognosis and provide reliable results to clinical decision-making and treatment selection for patients, is of paramount importance. Feature selection techniques, which aim at minimizing the dimensionality of the microarray data by keeping the most statistically significant genes, are a powerful approach toward this goal. In this paper, we investigate the minimum required subsets of genes, which best classify neuromuscular disease data. For this purpose, we implemented a methodology pipeline that facilitated the use of multiple feature selection methods and subsequent performance of data classification. Five feature selection methods on datasets from ten different neuromuscular diseases were utilized. Our findings reveal subsets of very small number of genes, which can successfully classify normal/disease samples. Interestingly, we observe that similar classification results may be obtained from different subsets of genes. The proposed methodology can expedite the identification of small gene subsets with high-classification accuracy that could ultimately be used in the genetics clinics for diagnostic, prognostic, and pharmacogenomic purposes.

BACKGROUND: Recently accumulating evidences underline the central role of the kallikrein-related peptidases family (KLKs) in prostate cancer (PCa) development and progression. The KLK4 is a prostate highly expressed gene under the transcriptional control of androgens, encoding for the KLK4 extracellular serine protease. The aim of this study is to investigate the expression status of KLK4 in PCa patients in order to reveal its utility in PCa establishment and clinical management. METHODS: Prostatic tissue specimens were obtained from 60 PCa and 59 benign prostate hyperplasia (BPH) randomly chosen patients. Using a developed quantitative real-time RT-PCR method, KLK4 expression levels were determined in the specimens of the two patients' cohorts. Advance biostatistical analysis was completed to explore the clinical value of KLK4 expression in PCa and BPH patients. RESULTS: PCa patients presented a statistically significant (P = 0.002) elevation, more than threefold, of the KLK4 transcripts compared to BPH ones. The KLK4 expression levels were also positive correlated with PCa patients' stage (P = 0.031) and preoperative prostate-specific antigen (PSA) serum concentrations (P < 0.001). ROC curve and logistic regression analysis revealed the significant (P = 0.002) and the independent (P = 0.044) clinical value of the KLK4 expression for the discrimination of PCa from BPH patients. CONCLUSIONS: The KLK4 expression analysis reveals its up-regulation in PCa cells, which is significantly associated with the advanced stages of the disease and the patients' preoperative PSA serum levels. KLK4 quantification serves as an independent biomarker for the discrimination between the malignant and the benign nature of prostate tumors.

Rapid northeast-vergent subduction along the Hellenic trench, at ~ 35 mm/yr, exists in concert with widespread extensional and strike-slip faulting within the upper plate lithosphere of western Greece. Integration of regional geomorphic, geologic, seismic, GPS, remote sensing and field data demonstrates that young and active deformation in the area, extending from the Hellenic subduction boundary near Kephalonia to the Gulf of Corinth, consists of an interconnected network containing highly localized zones of deformation. These bound a series of crustal fragments with relatively little internal deformation. These deformation zones merge to form triple junction-like features at the western end of the Gulf of Corinth and in the Amvrakikos Gulf. At the western end of the Corinth Gulf, most of its 14 ± 2 mm/yr of extension is relayed to the northwest along a prominent zone of left-slip and extension through Lake Trichonis and the Amphilochia fault zone (11 ± 2 mm/yr). The remaining displacement across the western Gulf of Corinth is relayed into 7 ± 2 mm/yr of right-slip on the southwest-striking Achaia fault zone, which traverses the northwestern margin of the Peloponnesus. A second triple-junction like feature occurs in the Amvrakikos Basin, where the left-slip Amphilochia fault zone, the right-slip Kephalonia transform fault (15 ± 2 mm/yr) and the convergent thrust front of northern Hellenides (4 ± 2 mm/yr) are joined. Thus the extensional deformation in the Gulf of Corinth can be shown to be connected to convergence and subduction along the Hellenic trench through a series of discrete deformation zones that are not dissimilar from those observed in the global plate tectonic system.

We investigate conditions in a radially self-similar outflow in the regime of large resistivity. Using the PLUTO code, we performed simulations with proper choice of boundary conditions, relaxed at the footpoints of critical surfaces in the flow. We investigate outflow propagation in a high-resistive disk corona, and compare it to the results with small or vanishing resistivity.

In this study we investigate the electronic transport, the optical properties, and photocurrent in two-dimensional arrays of silicon nanocrystals (Si NCs) embedded in silicon dioxide, grown on quartz and having sizes in the range between less than 2 and 20 nm. Electronic transport is determined by the collective effect of Coulomb blockade gaps in the Si NCs. Absorption spectra show the well-known upshift of the energy bandgap with decreasing NC size. Photocurrent follows the absorption spectra confirming that it is composed of photo-generated carriers within the Si NCs. In films containing Si NCs with sizes less than 2 nm, strong quantum confinement and exciton localization are observed, resulting in light emission and absence of photocurrent. Our results show that Si NCs are useful building blocks of photovoltaic devices for use as better absorbers than bulk Si in the visible and ultraviolet spectral range. However, when strong quantum confinement effects come into play, carrier transport is significantly reduced due to strong exciton localization and Coulomb blockade effects, thus leading to limited photocurrent. © 2011 Gardelis et al.

We report on the lateral transport in a single two-dimensional (2D) array of Si nanocrystals of different sizes grown by low pressure chemical vapor deposition (LPCVD) of silicon on a quartz substrate and subsequent oxidation at high temperature. The initial nanocrystal size in the z-direction was 5 nm, while it was reduced to ∼3 nm after oxidation. The nanocrystals in the x-y plane were connected by grain boundaries and/or by very thin silicon oxide barriers, while a thin oxide layer was formed on their surface. The electrical measurements showed that current in the film is mainly governed by thermionic emission over the barriers (grain boundaries or dielectric barriers) at high temperatures and by tunneling at lower temperatures. Charge traps at the interfaces of the silicon nanocrystals with the oxide and at the grain boundaries cause considerable hysteresis in the current-voltage characteristics. Hydrogen passivation of the charge traps reduces considerably the hysteresis effect and the activation energy of the thermionic emission, while revealing a clear Coulomb gap. © 2011 American Institute of Physics.

Light, scanning and transmission electron microscopy as well as histochemical reactions were employed to study the leaf structure and secretory activity of Ecballium elaterium, a hairy pharmaceutical perennial common in the Mediterranean region. The amphistomatic leaf has a peculiar structure due to special cells supporting the conductive bundles, a remarkable shortage of mechanical tissue, and the existence of pectin strands between mesophyll cells. The secreting activity is limited mostly to secretary hairs. These attributes of the Ecballium leaf fine structures do not resemble the common structure of leaves from Mediterranean plants and point to a peculiar strategy of this species coping with stress conditions of its habitat. © 2010 Elsevier GmbH.

We report on a 63-year-old woman, previously in good health, who had undergone nephrectomy for clear cell renal cell carcinoma in 2002. Because of systemic relapse with multiple lung metastases in 2006, the patient was treated with sunitinib 50 mg daily on a 4-weeks on-/2-weeks off-schedule. After 3 years of treatment, she developed a purpuric rash on her feet and trunk. Biopsy revealed leukocytoclastic vasculitis. No other organ involvement was diagnosed. She was started on oral prednisone 30 mg daily with rapid resolution of the vasculitic skin lesions. Sunitinib was temporally discontinued and reintroduced at the same dose level. Reappearance of a less serious vasculitis after 2 cycles of re-treatment was resolved in the weeks off-treatment and by reducing the dose of sunitinib along with 5 mg of prednisone daily. One year after the diagnosis, the patient is still on this therapy. Oncology providers should be aware of this rare but potentially serious, possible adverse effect of sunitinib. Copyright © 2011 S. Karger AG, Basel.

Recently, the European Medicines Agency (EMA) issued a new guideline on the investigation of bioequivalence (BE). In case of highly variable drugs, this guideline proposes that the acceptance limits for C-max can gradually be expanded as a function of within-subject variability (CVWR). Actually, these BE limits exhibit leveling-off properties since they are not allowed to scale continuously, but only up to CVWR = 50%. To avoid the risk of accepting two drug products which may differ significantly, this EMA guideline also proposes the use of a secondary constraint criterion on the geometric mean ratio (GMR) of the two products under comparison. Aim of this study was to explore the leveling-off properties of the new EMA limits in comparison to other approaches, as well as to assess the impact of the complementary GMR criterion on the ability to declare bioequivalence. Simulated bioequivalence studies and extreme GMR plots were used to assess the performance of the EMA limits. Three sequence, three period (3 x 3) crossover studies with two treatments (T and R) were simulated. The R product was considered to be administered twice, while the T only once (i.e., TRR/RTR/RRT). Among others, this study revealed the leveling-off properties of the new EMA limits. It was also shown that the complementary GMR-constraint is only effective when a large sample size is used and at regions of CVWR close to 50%. This GMR-criterion begins to be effective at sample sizes around 60 and becomes more prominent as the number of subjects participating in the BE study increases. For CVWR values lower than 50%, the GMR-constraint has no role. In case of within-subject variabilities greater than 50%, the impact of the GMR-constraint diminishes due to the leveling-off properties of the EMA limits. Compared to the classic 0.80-1.25 or the extended 0.75-1.33 criteria, the new EMA limits are more liberal at high CVWR values and allow greater differences between the two drug products to be declared bioequivalent. Finally, this study showed that the use of an approximate value (0.760) on the scaling factor proposed by EMA, has no impact on the performance of the new BE limits compared to other more accurate approaches. (C) 2011 Elsevier B.V. All rights reserved.

The liar and kindred paradoxes make it difficult to construct a consistent and plausible formal theory of truth. One approach is to tackle them not by restricting the principles about truth that pre-theoretically seem correct, but by deviating from classical logic. I outline a nonclassical propositional logic I have constructed within that approach, as well as a theory of truth embedded in the framework of the logic. (Preliminary presentation of some of the material that eventually became the paper 'A propositional theory of truth'.)

The species composition of the epiphytic benthic foraminiferal fauna was compared at two coastal locations in the Aegean Sea. Samples were collected during August 2001 and July 2003 along the southeastern coast of Andros Island at Korthi Gulf, where there are minimal anthropogenic activities, and at Kastro Gulf, with substantial anthropogenic influence. This study represents the first application of the FORAM Index (FI), which is a single-metric index for water quality originally developed for western Atlantic reef foraminiferal assemblages, to Mediterranean assemblages. Multivariate analyses distinguished three clusters of sample sites representing three foraminiferal assemblages. Samples dominated by the mixotrophic species, A. lobifera, were collected primarily from sites along the northern coasts of both gulfs. Characteristics of this assemblage, including relatively high dominance (D=0.27–0.51), lower Shannon–Wiener diversity (H′=1.3–2.1) and high FI (6.6–8.2), all reflect oligotrophic environmental conditions typical of pristine waters of the Aegean Sea. A. lobifera was typically the most common species in the second assemblage, though relative abundances of heterotrophic taxa were higher, resulting in somewhat higher diversity (H′=1.6–2.4) and lower dominance (D=0.14–0.36). These indices, as well as the FI range of 3.5–7.0 indicated somewhat more prevalent organic carbon resources but still relatively high water quality. This assemblage was found along the southern coast of Korthi Gulf and at more interior sites in northern Kastro Gulf. The third assemblage was dominated by smaller heterotrophic species, including notable proportions of the stress-tolerant taxa Ammonia spp. and Elphidium spp., and had few or no A. lobifera. Diversity (H′=1.4–2.0) and dominance (D=0.22–0.47) indices were similar to those for the first assemblage, but FI values were much lower (2.0–3.4). Samples characterized by this assemblage were collected only from the southern Kastro Gulf, in the vicinity of the primary sewage outfall. The results of this study document the sensitivity of benthic foraminiferal assemblages, and particularly A. lobifera populations, to sewage pollution in the Aegean Sea. These observations are consistent with studies from other biogeographic regions where the FORAM Index, which is based upon this genus and associated mixotrophic taxa, has been used as a water-quality indicator. This observation is particularly noteworthy because A. lobifera is an invasive species in the Mediterranean. 

In this study, the trends and variability of annual precipitation totals and annual rain days over land within the Mediterranean region are analyzed. Long term ground-based observations concerning, on one hand, monthly precipitation totals (1900-2010) and rain days (1965-2010) from 40 meteorological stations within the Mediterranean region were obtained from the Hellenic National Meteorological Service and the World Climate Data and Monitoring Programme (WCDMP) of the World Meteorological Organization. On the other hand, high spatial resolution (0.5 × 0.5 ) gridded monthly data CRU TS 3.1 were acquired from the Climatic Research Unit, University of East Anglia, for the period 1901-2009. The two datasets were compared by means of trends and variability, while the influence of the North Atlantic Oscillation (NAO) in the Mediterranean precipitation was examined. In the process, the climatic changes in the precipitation regime between the period 1961-1990 (reference period) and the period 2071-2100 (future climate) were presented using climate model simulations (RACMO2.1/KNMI). The future climate projections were based on SRES A1B. The findings of the analysis showed that statistically significant (95% confidence level) negative trends of the annual precipitation totals exist in the majority of Mediterranean regions during the period 1901-2009, with an exception of northern Africa, southern Italy and western Iberian peninsula, where slight positive trends (not statistically significant at 95% CL) appear. Concerning the annual number of rain days, a pronounced decrease of 20 %, statistically significant (95% confidence level), appears in representative meteorological stations of east Mediterranean, while the trends are insignificant for west and central Mediterranean. Additionally, NAO index was found to be anticorrelated with the precipitation totals and the number of rain days mainly in Spain, southern France, Italy and Greece. These correlations are higher within the rain season (October-March) than the entire year. Based on the results of regional climate model RACMO2.1/KNMI, precipitation is very likely to decrease almost 20% in the period 2071-2100 compared to 1961-1990, under SRES A1B. © Author(s) 2011.

The inter-annual/decadal scale variability of the Aegean Sea Surface Temperature (SST) is investigated by means of long-term series of satellite-derived and in situ data. Monthly mean declouded SST maps are constructed over the 1985?2008 period, based on a re-analysis of AVHRR Oceans Pathfinder optimally interpolated data over the Aegean Sea. Basin-average SST time series are also constructed using the ICOADS in situ data over 1950?2006. Results indicate a small SST decreasing trend until the early nineties, and then a rapid surface warming consistent with the acceleration of the SST rise observed on the global ocean scale. Decadal-scale SST anomalies were found to be negatively correlated with the winter North Atlantic Oscillation (NAO) index over the last 60 years suggesting that along with global warming effects on the regional scale, a part of the long-term SST variability in the Aegean Sea is driven by large scale atmospheric natural variability patterns. In particular, the acceleration of surface warming in the Aegean Sea began nearly simultaneously with the NAO index abrupt shift in the mid-nineties from strongly positive values to weakly positive/negative values.

Este trabajo analiza los errores léxicos intralinguales semánticos de las composiciones en español por 81 aprendices griegos de diferentes niveles lingüísticos (A, B1, B2, C1) utilizando el método de Análisis de Errores. Los resultados del análisis cualitativo muestran que las estrategias más usadas son la asociación fonológica y semántica entre las palabras de la LE. Los resultados del análisis cuantitativo indican que tanto toda la categoría de los errores como sus diferentes tipos ascienden a medida que avanza el nivel lingüístico de los informantes.

The paper is partly motivated by recent pump-probe experiments with ultrashort laser pulses on antiferromagnetic FeRh that have shown the generation of magnetization within a subpicosecond time scale. On the other hand, the physical mechanism of the thermal antiferromagnetic-ferromagnetic (AFM-FM) phase transition in FeRh, known for many decades, remains a topic of controversial discussions. The selection of the magnetic degrees of freedom as well as the treatment of the magnetic excited states differ strongly in recent models by different authors. We report a density functional theory (DFT) investigation of FeRh. For the study of excited states, DFT calculations with constraints imposed on the directions and values of the atomic moments are employed. We show that the formation of the Rh moment as a consequence of the AFM-FM phase transition cannot be described within the Stoner picture. Instead, an implicit spin splitting of the Rh states takes place in the AFM phase, resulting in the intra-atomic spin polarization of the Rh atoms. This property is a consequence of the strong hybridization between Rh and Fe states. The Fe-Rh hybridization is an important factor in the physics of FeRh. We demonstrate that the ferromagnetic Fe-Rh exchange interaction is robust with respect to the crystal volume variation, whereas the antiferromagnetic Fe-Fe exchange interaction is strongly volume dependent. These different volume dependencies of the competing exchange interactions lead to their strong compensation at certain crystal volume. We perform Monte Carlo simulations and show that the calculated thermodynamics depends on the way the magnetic degrees of freedom are selected. We argue that the excited states resulting from the variation of the value of the Rh moment treated as degree of freedom are important for both the equilibrium thermodynamics of FeRh and the femtomagnetic phenomena in this system. We also study the spin mixing caused by spin-orbit coupling. The obtained value of the Elliott-Yafet spin-mixing parameter is comparable with earlier calculations for the ferromagnetic 3d metals. We draw the conclusion that the Elliott-Yafet mechanism of the angular-momentum transfer between electrons and lattice plays an important role in the femtomagnetic properties of FeRh.

Magnetic resonance imaging is considered the gold-standard imaging technique in cases of Müllerian and vaginal anomalies, however, vaginal delineation often proves difficult, owing to the fact that vaginal walls are normally collapsed and in close proximity. Instilling gel through the introitus allows for better depiction of the distal vagina. © 2011 American Society for Reproductive Medicine.

Advanced transitional-cell carcinoma of the bladder is the most common cancer of the urinary tract, with a high mortality rate. Cisplatin-based chemotherapy has demonstrated prolonged survival of these patients and is considered the standard of care. Nevertheless, 40-50% of patients have impaired renal function that precludes the use of cisplatin. The non-nephrotoxic platinum analogue, carboplatin, has emerged as the most popular alternative in this setting, used mainly in doublets. However, it has not shown similar efficacy to cisplatin. In this article, platinum-based or platinum-free regimens, monotherapies or combination therapies are discussed as treatment options for this population. Their efficacy and toxicity are also being analyzed. The study of newer targeted therapies in the treatment of bladder cancer is also discussed, as are future perspectives and a five-year view in the treatment of the disease in patients with renal impairment. © 2011 Expert Reviews Ltd.

Objective: To evaluate alterations in the concentrations of osteoprotegerin (OPG), RANKL and the OPG/RANKL ratio in pre-eclamptic women during the puerperium. Study design: This cross-sectional study was performed in the maternity ward of Aretaieio Hospital in Athens, Greece. Fifteen pregnant women with severe pre-eclampsia and 15 matched controls with premature rupture of the membranes were recruited. Fasting blood samples were obtained antepartum, immediately after diagnosing pre-eclampsia (median: 32nd gestational week), and during the 3rd-6th day postpartum, to estimate levels of circulating OPG and RANKL as well as the OPG/RANKL ratio. The anthropometric parameters evaluated included body mass index and blood pressure. Results: Mean circulating OPG levels decreased significantly in both groups in the postpartum period (controls: 43.7 ± 19.1 ng/ml vs 22.9 ± 9.1 ng/ml, p = 0.008; pre-eclamptic group: 72.3 ± 49.9 vs 49.7 ± 40.9 ng/ml, p = 0.002). The antepartum OPG/RANKL ratio was elevated in hypertensive pregnancies (2.41 ± 1.72) compared to normotensive pregnancies (1.45 ± 0.63), but the difference did not reach statistical significance (p = 0.1). The OPG/RANKL ratio decreased in the control group (0.76 ± 0.30, NS) following delivery, while it remained unchanged in the pre-eclamptic women (1.63 ± 1.40, p = 0.13). Consequently, the postpartum OPG/RANKL ratio was significantly higher in the pre-eclamptic women compared to control women (1.63 ± 1.40 vs 0.76 ± 0.30, p = 0.01). Levels of RANKL demonstrated no significant alterations during puerperium in both cases. Conclusion: Pregnancies complicated with pre-eclampsia exhibit higher OPG levels and OPG/RANKL ratios, compared to control pregnancies, which might be compatible with lower bone turnover. The significance of this finding with respect to bone metabolism remains to be elucidated in larger studies. © 2010 Elsevier Ireland Ltd.

OBJECTIVE: Cerebrovascular disease is 1 of the possible mechanisms of the previously reported relationship between Mediterranean-type diet (MeDi) and Alzheimer's disease (AD). We sought to investigate the association between MeDi and MRI infarcts. METHODS: High-resolution structural MRI was collected on 707 elderly 65 years or older community residents of New York with available dietary assessments administered an average of 5.8 years (3.22 standard deviations [SDs]) before the MRI. Participants were divided into 3 groups of adherence to MeDi (low, middle, and high tertiles). We examined the association of increasing adherence to MeDi with presence of infarcts on MRI. Models were run without adjustment, adjusted for basic demographic and clinical factors, and adjusted for vascular risk factors. RESULTS: A total of 222 participants had at least 1 infarct. In the unadjusted model, compared to the low adherence group, those in the moderate MeDi adherence group had a 22% reduced odds of having an infarct (odds ratio [OR], 0.78; 95% confidence interval [CI], 0.55-1.14), while participants in the highest MeDi adherence group had a 36% reduced odds (OR, 0.64; 95% CI, 0.42-0.97; p for trend = 0.04). In adjusted models, the association between MeDi adherence and MRI infarcts remained essentially unchanged. The association of high MeDi adherence with infarcts was comparable to that of hypertension (40% reduced probability), did not vary by infarct size or after excluding patients with dementia (n = 46) or clinical strokes (n = 86). There was no association between MeDi and white matter hyperintensities. INTERPRETATION: Higher adherence to the MeDi is associated with reduced cerebrovascular disease burden.

The Mediterranean dietary pattern has a well-established beneficial role in health promotion. Epidemiologic studies reveal the protective role of adherence to this pattern on overall cancer incidence and mortality. This review examines results from prospective cohort, cross-sectional, and case-control studies assessing the role of the Mediterranean diet in cancer prevention. Original research studies that were published in English between 1985 and April 6, 2010, were selected through a computer-assisted literature search (i.e., PubMed and Scopus). From the initial search, 273 papers were selected. After the titles and the abstracts of these papers were read for relevance to this review, 17 studies were selected and are discussed here; 8 had a prospective design, 7 were case-control, 1 was a randomized screening study, and 1 was an interventional study. Although there is a lack of definitive evidence for the association of Mediterranean diet with various types of cancer, a dietary pattern emphasizing the consumption of fruits and vegetables, whole grains, legumes, nuts, seeds, and low-fat dairy products could be highly recommended for all people, and especially those at risk for cancer. © 2011 Mary Ann Liebert, Inc.

BACKGROUND: A dietary pattern common in regions near the Mediterranean appears to reduce risk of all-cause mortality and ischemic heart disease. Data on blacks and Hispanics in the United States are lacking, and to our knowledge only one study has examined a Mediterranean-style diet (MeDi) in relation to stroke. OBJECTIVE: In this study, we examined an MeDi in relation to vascular events. DESIGN: The Northern Manhattan Study is a population-based cohort to determine stroke incidence and risk factors (mean ± SD age of participants: 69 ± 10 y; 64% women; 55% Hispanic, 21% white, and 24% black). Diet was assessed at baseline by using a food-frequency questionnaire in 2568 participants. A higher score on a 0-9 scale represented increased adherence to an MeDi. The relation between the MeDi score and risk of ischemic stroke, myocardial infarction (MI), and vascular death was assessed with Cox models, with control for sociodemographic and vascular risk factors. RESULTS: The MeDi-score distribution was as follows: 0-2 (14%), 3 (17%), 4 (22%), 5 (22%), and 6-9 (25%). Over a mean follow-up of 9 y, 518 vascular events accrued (171 ischemic strokes, 133 MIs, and 314 vascular deaths). The MeDi score was inversely associated with risk of the composite outcome of ischemic stroke, MI, or vascular death (P-trend = 0.04) and with vascular death specifically (P-trend = 0.02). Moderate and high MeDi scores were marginally associated with decreased risk of MI. There was no association with ischemic stroke. CONCLUSIONS: Higher consumption of an MeDi was associated with decreased risk of vascular events. Results support the role of a diet rich in fruit, vegetables, whole grains, fish, and olive oil in the promotion of ideal cardiovascular health.

Metal-on-metal (MoM) total hip arthroplasty (THA) has been introduced in an attempt to reduce the wear rate and the consequent osteolysis around implants. The aim of this study was to present the intermediate to long-term clinical and radiological outcomes and to investigate the metal ion levels in the blood of patients who had undergone primary uncemented MoM THA in our institution. Between July 1997 and November 2003, 166 patients (193 hips), with a mean age of 50 years (range, 18-65 years), underwent primary MoM THA. Clinical data, radiographs, and blood samples were obtained at regular follow-up visits. Cobalt (Co), chromium (Cr), and molybdenum (Mo) ions were measured by inductively coupled plasma-mass spectrometry (ICP-MS) from the patient's whole blood. All patients were prospectively followed for a minimum of 5 years (mean, 7 years; range, 5-11 years). The mean Harris hip score (HHS) and the University of California at Los Angeles (UCLA) activity score at the latest follow-up was 88 ± 11 and 7 ± 1.8 points, respectively. Thirteen hips have been revised. Ten acetabular components had early failure, due to factory manufacturing problems. All other implants have been found stable, with no signs of aseptic loosening. The probability of survival at 11 years, if the hips that were revised due to manufacturing problems were excluded, was 98.4%. The Co and Cr metal ion levels, after increasing significantly during the first 4 to 5 years post-surgery, remained stable, with a tendency to decrease thereafter, but not significantly. During the same follow-up period, Mo ion levels remained stable. In this 5-to-11 year follow-up study of MoM THA patients, excellent survivorship, with low complications rates, was found. Results of longer follow-up studies are necessary to clarify the possible long-term effects of metal ion release.

Urban particulate matter (PM 10-PM 2.5 and PM 2.5) from Athens (Greece) atmosphere, primarily investigated by SEM-EDS, was further studied in the FLUO and SUL-X beamlines of ANKA Synchrotron facility (KIT, Germany). The SR μ-XRF study showed both geological (e.g. CaTi, CaK and CaSrKRb) and anthropogenic particles exhibiting heavy metal combinations such as FeCo, FeCoCuV and ZnV. It was also revealed that very hazardous metalloids and heavy metals, namely As and Pb, are concentrated in isolated respirable (PM 2.5) microparticles. It was attempted to investigate the oxidation state of As by means of μ-XANES. The As K-edge XANES spectrum of the sample shows a main peak at about 11.874 keV which matches adequately with the As(V) reference spectrum but part of the As seems to have a lower oxidation state (most probably As(III)). This is the first non-bulk study with regard to the partitioning and solid-state speciation of hazardous chemical elements in urban atmospheric microparticles from greater Athens area, rated as an alpha-world city with a population of ca. 4 million people. © 2011 Elsevier B.V. All rights reserved.

Urban particulate matter (PM10–PM2.5 and PM2.5) from Athens (Greece) atmosphere, primarily investigated by SEM-EDS, was further studied in the \{FLUO\} and SUL-X beamlines of \{ANKA\} Synchrotron facility (KIT, Germany). The \{SR\} μ-XRF study showed both geological (e.g. CaTi, CaK and CaSrKRb) and anthropogenic particles exhibiting heavy metal combinations such as FeCo, FeCoCuV and ZnV. It was also revealed that very hazardous metalloids and heavy metals, namely As and Pb, are concentrated in isolated respirable (PM2.5) microparticles. It was attempted to investigate the oxidation state of As by means of μ-XANES. The As K-edge \{XANES\} spectrum of the sample shows a main peak at about 11.874 keV which matches adequately with the As(V) reference spectrum but part of the As seems to have a lower oxidation state (most probably As(III)). This is the first non-bulk study with regard to the partitioning and solid-state speciation of hazardous chemical elements in urban atmospheric microparticles from greater Athens area, rated as an alpha-world city with a population of ca. 4 million people.

 

This paper focuses on the study of the geomorphological processes and the impact of neotectonic deformation on the geomorphological structure. A vast database was developed, containing different kinds of information, concerning geology, topography, drainage characteristics, vegetation and land use of the Ionian Islands. A geographic information system platform was developed in order to analyse the data, and to model and finally map the prevailing geomorphological processes: the erosion and deposition zones.Erosion risk factors have been processed in order to develop erosion risk maps demonstrating vulnerable to erosion areas. This study also concludes that the Ionian Islands are strongly influenced by the neotectonic processes that have defined their current morphology.

The extracellular slime of Staphylococcus epidermidis contains, amongst various macromolecules, an acidic polysaccharide (PS) of a molecular mass of 20 kDa with significant antigenic and biological properties. The isolation procedure used so far includes multiple fractionations in anion-exchange chromatographic columns before its final purification by gel filtration chromatography. This protocol is laborious, time-consuming and includes the risk of unnecessary loss of PS quantities. Because of the significance of this PS, a modified protocol resulting in an easier and quicker isolation procedure was developed. Furthermore, identification, purity, charge density and molecular integrity of the isolated polysaccharide were evaluated by a reverse-polarity capillary electrophoresis method.

Gastric cancer is the second leading cause of cancer related-death. Most patients present with an advanced stage of disease that has a dismal outcome. Evidently, there is a clear need for the development of new agents with novel mechanisms of action in the treatment of this disease. A number of biological agents modulating different signal transduction pathways are currently in clinical development, such as angiogenesis inhibitors and agents targeting epidermal growth factor receptor, cell cycle, matrix metalloproteinases, cyclooxygenase-2 (COX-2), mammalian target of rapamycin (mTOR) or proteasome. This is the first systematic review of the literature to synthesize all available data coming from trials and evaluate the efficacy and safety of molecular targeted drugs in unresectable and metastatic gastric cancer. As knowledge accumulates on the molecular mechanisms underlying carcinogenesis in the stomach, the anticipated development and assessment of molecularly targeted agents may offer a promising perspective for a disease which, to date, remains incurable. © 2011 Elsevier Ltd.

The identification of a monoclonal protein in serum protein electrophoresis (SPEP) is a common event requiring medical consultation. A monoclonal protein may be the hallmark of a malignant disease, such as multiple myeloma or Waldenstrom's Macroglobulinemia (and less often of other lymphoproliferative disorders), of diseases associated with a malignant plasma cell clone, such as AL amyloidosis or other plasma cell related disorders, or, quite commonly may have no direct impact and belong to monoclonal gammopathies of undetermined significance (MGUS). Jan Waldenstrom introduced the term “essential hyperglobulinemia” in order to describe patients who had a small serum protein electrophoretic spike but no evidence of overt multiple myeloma (MM), Waldenstrom's macroglobulinemia (WM), primary amyloidosis (AL), or related disorders. The seminal work by Kyle indicated that some patients with this monoclonal gammopathy develop MM, or WM or AL or other lymphoproliferative malignancies, and introduced the term “monoclonal gammopathy of undetermined significance” (MGUS)[1]. Kyle also described patients with histologic and biochemical features of myeloma (bone marrow clonal plasma cells (BMPC) involvement of 10% or higher, presence of a serum M-protein value higher than 3 g/dl) that did not have lytic bone lesions, anemia, renal impairment or other clinical manifestations of myeloma who remained stable, with no need for chemotherapy, for several years[2]. Alexanian also presented data on “indolent myeloma”[3], that included patients who had no clinical features of overt myeloma such as anemia and renal dysfunction and had fewer than three lytic bone lesions. Among these patients, median time to initiation of chemotherapy was two years, but some patients remained stable for several years. Thus, the term “smoldering” MM or “asymptomatic” or “indolent” MM, entered the clinical practice. The definitions, however, were not strict among different groups. In 2003 a consensus paper defined MGUS and asymptomatic or smoldering myeloma (Table 10.1). MGUS requires that M-protein in serum is <30 g/l and that bone marrow clonal plasma cells are <10% with no evidence of other B cell proliferative disorders and no end organ damage (anemia, renal impairment, hypercalcemia, lytic bone lesions). © Cambridge University Press 2014.

We highlight some physical and mathematical aspects relevant to the derivation and use of the Higuchi equation. More specifically, the application of the Higuchi equation to different geometries is discussed and Monte Carlo simulations to verify the validity of Higuchi law in one and two dimensions, as well as the derivation of the Higuchi equation under alternative boundary conditions making use of fractional calculus, are presented. (C) 2010 Elsevier B.V. All rights reserved.

The primary aim of the present study was to assess morphological covariation between the face and the basicranium (midline and lateral), and to evaluate patterns of integration at two specific developmental stages. A group of 71 children (6-10 years) was compared with a group of 71 adults (20-35 years). Lateral cephalometric radiographs were digitized and a total of 28 landmarks were placed on three areas; the midline cranial base, the lateral cranial base and the face. Geometric morphometric methods were applied and partial least squares analysis was used to evaluate correlation between the three shape blocks. Morphological integration was tested both with and without removing the effect of allometry. In children, mainly the midline and, to a lesser extent, the lateral cranial base were moderately correlated to the face. In adults, the correlation between the face and the midline cranial base, which ceases development earlier than the lateral base, was reduced. However, the lateral cranial base retained and even strengthened its correlation to the face. This suggests that the duration of common developmental timing is an important factor that influences integration between craniofacial structures. However, despite the apparent switch of primary roles between the cranial bases during development, the patterns of integration remained stable, thereby supporting the role of genetics over function in the establishment and development of craniofacial shape.

Naxos is the largest island of the Cyclades (Aegean Sea, Greece), covering an area of ca 450 km². Its 150 km long coasts exhibits various morphological features such as cliffs, lagoons and beaches. These latter are largely preserved along the western coast, between the main city (Chora) and Pyrgaki, and are associated with well-developed dune fields. A few dunes fields are also preserved along the Eastern part (Azala Bay, Psili Ammos). Field study made it possible to propose an updated geomorphological mapping of the dune fields. Four landforms have hence been recognized, especially on the basis of their form, size, location and vegetation cover. Assuming that these various landforms relate to at least three Holocene aggradation periods, a geochronological approach was developed in order to unravel the climate influence on the Naxos dunes formation. 24 OSL dating were performed at the Leibniz Institute for Applied Geophysics (LIAG, Hannover, Germany) on samples from two main dune fields : Aliko (West coast) and Psili Ammos (East coast). We here present the first results and interpretations of these geochronological research.

Present morphological and tectonic image of Ikaria island is the complex result of both the tem-poral evolution of the island, as part of the geodynamical evolution of the Hellenic Arc, especially that of the last stages (from the upper Miocene and after), and the exogenous factors. Also human impact functions as an additional parameter for the formation of Ikaria geoenvironment.According to field data and their analysis, computing and estimation which took part with the use of modern technologies (use of GIS, analysis of geographical and descriptive databases) the mor-photectonic units of Ikaria Island were defined. The definition of the morphotectonic units was based on their special features and more precisely on the lithological differentiation (granite, metamorphic rocks and post alpine formations) as well as the complex ductile and brittle structures (large scale ductile shear-zones and brittle detachment faults, normal faults, strike-slip transfer faults and join sets) and the morphological features (slope distribution, asymmetry of the drainage system, planation surfaces, morphological discontinuities etc).The synthesis of the special features of each morphotectonic unit in combination with the human impact (fires, overgrazing etc), defines the kind, the intensity and the geographical localization of the natural hazards which occur in various sites of the island, such as landslides, erosion, floods, seismic activity, relief changes, coastline changes etc.

The arrival of the novel agents thalidomide, bortezomib, and lenalidomide has significantly changed our approach to the management of multiple myeloma and, importantly, patient outcomes have improved. These agents have been investigated intensively in different treatment settings, providing us with data to make evidence-based decisions regarding the optimal management of patients. This review is an update to a previous summary of European treatment practices that examines new data that have been published or presented at congresses up to the end of 2010 and assesses their impact on treatment practices. © AlphaMed Press.

We present an extension of the layer-multiple-scattering method to phononic crystals of nonspherical particles in a homogeneous host medium by employing the extended-boundary-condition technique for the description of the individual scatterers. The efficiency of the method is demonstrated on specific examples of two- and three-dimensional periodic assemblies of spheroidal polymer particles in water and in silicon. We report a thorough analysis of the acoustic properties of these composites and emphasize aspects of the underlying physics that relate to the nonspherical shape of the particles.

The purpose of the present study was to assess the relative importance of selected performance indicators in modern top-level handball through the analysis of offensive actions in three consecutive men’s world championships (2005, 2007 and 2009). A total of 288 matches were examined, which included 29,439 throw attempts resulting in 16,240 goals. The results demonstrated the strong relationship between the six-meter and nine-meter offensive actions, as evidenced by their very high negative correlation coefficients in both the throw attempts and goals scored. The significant decrease of the throw attempts and goals scored from the six-meter position, evidenced in the 2007 and 2009 championships, is associated with the collateral significant increase of the nine-meter throws and goals. Interestingly, the nine-meter efficacy remained relatively constant throughout the three competition years, while the six-meter efficacy depicted a significant increase in competition years 2007 and 2009 compared to 2005, as a result of the appearance of highlyqualified top ranking players in the pivot position. The high performance efficiency of these players resulted in adaptive defensive tactics to prevent the ball from reaching this key position. The present findings provide valuable information to handball coaches, in the design of their strategic and tactical plans.

The aim of this study was to identify volleyball performance indicators that best discriminate between winning and losing teams in a set according to set final score differences. The data were collected from teams’ performances (N=350) in all sets played during the 2009 Men’s European Volleyball Championship in Turkey. Clusters analysis established three different groups of sets according to set final score difference: 2 points (ambivalent), 3-5 points (safe), >5 points (unbalanced). A 3x2 MANOVA (type of set x type of result) was then performed on 9 performance indicators reflecting % expressions of four basic skills of the game (serve, pass, attack, block). The analysis revealed significant multivariate differences in type of set, in type of results, and in their interaction. A follow-up Discriminant Analysis showed that effectiveness of attack is the most important performance indicator for all types of sets, far more for the ambivalent ones. The discriminant function correctly classified increasing % of cases with increase in score difference. Especially for ambivalent sets 67.3% were correctly classified, letting some space for further improving the critical performance indicators. The results suggest that training of a men’s volleyball team should emphasize more to improve offensive abilities.

The aim of this study was to identify volleyball performance indicators that best discriminate between winning and losing teams in a set according to set final score differences. The data were collected from teams’ performances (N=350) in all sets played during the 2009 Men’s European Volleyball Championship in Turkey. Clusters analysisestablished three different groups of sets according to set final score difference: 2 points (ambivalent), 3-5 points (safe), >5 points (unbalanced). A 3x2 MANOVA (type of set x type of result) was then performed on 9 performance indicators reflecting % expressions of four basic skills of the game (serve, pass, attack, block). The analysis revealed significant multivariate differences in type of set, in type of results, and in their interaction. A follow-up Discriminant Analysis showed that effectiveness of attack is the most important performance indicator for all types of sets, far more for the ambivalent ones. The discriminant function correctly classified increasing % of cases with increase in score difference. Especially for ambivalent sets 67.3% were correctly classified, letting some space for further improving the critical performance indicators. The results suggest that training of a men’s volleyball teamshould emphasize more to improve offensive abilities.

Repeated-sprint training often involves short sprints separated by inadequate recovery intervals. The effects of interval duration on metabolic and performance parameters are unclear. We compared the effects of two training programmes, differing in rest interval duration, on muscle (vastus lateralis) metabolism and sprint performance. Sixteen men trained three times a week for 8 weeks, each training session comprising 2-3 sets of two 80-m sprints. Sprints were separated by 10 s (n = 8) or 1 min (n = 8). Both training programmes improved performance in the 100-, 200-, and 300-m sprints, but the improvement was greater in the 10-s group during the final 100 m of the 200- and 300-m runs. Independent of interval duration, training mitigated the drop of muscle ATP after two 80-m sprints. The drop in phosphocreatine and the increases in glucose-6-phosphate and fructose-6-phosphate after two 80-m sprints were greater in the 10-s group. In conclusion, training with a limited number of repeated short sprints (≤10 s) may be more effective in improving speed maintenance in 200- and 300-m runs when performed with a 1:1 rather than a 1:6 exercise-to-rest ratio. This may be due to a greater activation of glycolysis caused, in part, by the limited resynthesis of phosphocreatine during the very short rest interval. © 2011 Taylor & Francis.

Repeated-sprint training often involves short sprints separated by inadequate recovery intervals. The effects of interval duration on metabolic and performance parameters are unclear. We compared the effects of two training programmes, differing in rest interval duration, on muscle (vastus lateralis) metabolism and sprint performance. Sixteen men trained three times a week for 8 weeks, each training session comprising 2-3 sets of two 80-m sprints. Sprints were separated by 10 s (n = 8) or 1 min (n = 8). Both training programmes improved performance in the 100-, 200-, and 300-m sprints, but the improvement was greater in the 10-s group during the final 100 m of the 200- and 300-m runs. Independent of interval duration, training mitigated the drop of muscle ATP after two 80-m sprints. The drop in phosphocreatine and the increases in glucose-6-phosphate and fructose-6-phosphate after two 80-m sprints were greater in the 10-s group. In conclusion, training with a limited number of repeated short sprints (≤10 s) may be more effective in improving speed maintenance in 200- and 300-m runs when performed with a 1:1 rather than a 1:6 exercise-to-rest ratio. This may be due to a greater activation of glycolysis caused, in part, by the limited resynthesis of phosphocreatine during the very short rest interval. © 2011 Taylor & Francis.

Repeated-sprint training often involves short sprints separated by inadequate recovery intervals. The effects of interval duration on metabolic and performance parameters are unclear. We compared the effects of two training programmes, differing in rest interval duration, on muscle (vastus lateralis) metabolism and sprint performance. Sixteen men trained three times a week for 8 weeks, each training session comprising 2-3 sets of two 80-m sprints. Sprints were separated by 10 s (n = 8) or 1 min (n = 8). Both training programmes improved performance in the 100-, 200-, and 300-m sprints, but the improvement was greater in the 10-s group during the final 100 m of the 200- and 300-m runs. Independent of interval duration, training mitigated the drop of muscle ATP after two 80-m sprints. The drop in phosphocreatine and the increases in glucose-6-phosphate and fructose-6-phosphate after two 80-m sprints were greater in the 10-s group. In conclusion, training with a limited number of repeated short sprints (≤10 s) may be more effective in improving speed maintenance in 200- and 300-m runs when performed with a 1:1 rather than a 1:6 exercise-to-rest ratio. This may be due to a greater activation of glycolysis caused, in part, by the limited resynthesis of phosphocreatine during the very short rest interval. © 2011 Taylor & Francis.

Earlier, we identified mutations in the first transmembrane segment (TMS1) of UapA, a uric acid-xanthine transporter in Aspergillus nidulans, that affect its turnover and subcellular localization. Here, we use one of these mutations (H86D) and a novel mutation (I74D) as well as genetic suppressors of them, to show that TMS1 is a key domain for proper folding, trafficking and turnover. Kinetic analysis of mutants further revealed that partial misfolding and deficient trafficking of UapA does not affect its affinity for xanthine transport, but reduces that of uric acid and confers a degree of promiscuity towards the binding of other purines. This result strengthens the idea that subtle interactions among domains not directly involved in substrate binding refine the selectivity of UapA. Characterization of second-site suppressors of H86D revealed a genetic interaction of TMS1 with TMS3, the latter segment shown for the first time to be important for UapA function. Systematic mutational analysis of polar and conserved residues in TMS3 showed that Ser154 is crucial for UapA transport activity. Our results are in agreement with a topological model of UapA built on the recently published structure of UraA, a bacterial homolog of UapA.

The optical and structural properties of cadmium and lead sulfide nanocrystals deposited on mesoporous TiO2 substrates via the successive ionic layer adsorption and reaction method were comparatively investigated by reflectance, transmittance, micro-Raman and photoluminescence measurements. Enhanced interfacial electron transfer is evidenced upon direct growth of both CdS and PbS on TiO2 through the marked quenching of their excitonic emission. The optical absorbance of CdS/TiO2 can be tuned over a narrow spectral range. On the other side PbS/TiO2 exhibits a remarkable band gap tunability extending from the visible to the near infrared range, due to the distinct quantum size effects of PbS quantum dots. However, PbS/TiO2 suffers from severe degradation upon air exposure. Degradation effects are much less pronounced for CdS/TiO2 that is appreciably more stable, though it degrades readily upon visible light illumination. © 2011 Kontos et al.

Recent years have witnessed tremendous research in quantum dots as excellent models of quantum physics at the nanoscale and as excellent candidates for various applications based on their optoelectronic properties. This review intends to present theoretical and experimental investigations of the near-field optical properties of these structures, and their multimodal applications such as biosensors, biological labels, optical fibers, switches and sensors, visual displays, photovoltaic devices and related patents.

We report on the optical response and, in particular, on the refractive properties of an fcc crystal of metallic nanoshells by means of full-electrodynamic layer-multiple-scattering simulations. Exact numerical calculations of the isofrequency surfaces reveal the existence of two frequency regions where negative refraction occurs. A thorough analysis of the photonic band structure, in conjunction with corresponding transmission diagrams, attributes this behavior to the excitation of collective modes, which stem from dipole particle-plasmon resonances, and shows that only in one of the two frequency regions negative refraction without birefringence can be obtained. In addition, we discuss the effect of absorptive losses, and reveal the existence of narrow bands of slab modes in a finite slab of the crystal that can transfer the evanescent components of an incident wave field.

The treatment of Waldenström's macroglobulinemia (WM) has changed over the last decades, mainly because of the introduction of nucleoside analogues and of rituximab while novel agents such as bortezomib have been recently introduced. We performed an analysis to investigate whether the outcome of patients with WM has improved over the last years, compared to that of patients who started treatment before new drugs became widely available, especially as part of the frontline treatment. We analyzed 345 symptomatic patients with WM: 130 who initiated treatment before and 215 who started treatment after January 1, 2000. Patients who started treatment in the latter group were older and had more often elevated beta2-microglobulin but the other characteristics were similar between the two groups. Most patients who started treatment before January 1, 2000 were treated upfront with alkylating agent-based regimens and most patients who started treatment after January 1, 2000 received rituximab-based regimens as initial treatment. Objective response (63 and 59%, respectively) and median overall survival, OS, (106.5 months for Group A and is estimated at 94 months for Group B, P = 0.327) were similar. There was also no difference regarding OS or cause specific survival (CSS) in each risk group according to IPSSWM. Our observation may be explained by the indolent course of WM in several patients and by the lack of profound cytoreduction in patients with high-risk disease. Possible differences in the 15- or 20-year survival rate between the two groups may be detected with further follow-up of these patients. © 2011 Wiley-Liss, Inc.

This review attempts to outline the alternative measures and interventions used in bloodless surgery in the field of gynecologic oncology and demonstrate their effectiveness. Nowadays, as increasingly more patients are expressing their fears concerning the potential risks accompanying allogenic transfusion of blood products, putting the theory of bloodless surgery into practice seems to gaining greater acceptance. An increasing number of institutions appear to be successfully adopting approaches that minimize blood usage for all patients treated for gynecologic malignancies. Preoperative, intraoperative and postoperative measures are required, such as optimization of red blood cell mass, adequate preoperative plan and invasive hemostatic procedures, assisting anesthetic techniques, individualization of anemia tolerance, autologous blood donation, normovolemic hemodilution, intraoperative cell salvage and pharmacologic agents for controlling blood loss. An individualised management plan of experienced personnel adopting a multidisciplinary team approach should be available to establish non-blood management strategies, and not only on demand of the patient, in the field of gynecologic oncology with the use of drugs, devices and surgical-medical techniques. © 2011 Simou et al; licensee BioMed Central Ltd.

The interaction between acoustic breathing modes and optical Mie resonances in a spherical particle made of a chalcogenide glass material is investigated by means of rigorous calculations, correct to any order in the acousto-optic coupling parameter. Our results reveal the occurrence of strong effects beyond the linear-response approximation, which lead to enhanced modulation of light by acoustic waves through multiphonon exchange mechanisms when both photons and phonons have a very long lifetime inside the particle.

For decades, parenteral drugs, such as the low molecular weight heparins and unfractionated heparins or vitamin K antagonists, have been used as anticoagulants for prevention of venous thromboembolism following major lower limb surgery. However, these regiments have limitations that rendered the quest for new anticoagulants mandatory. Recently, research has been focused on the development of orally active small molecules that directly target thrombin or activated factor X (FXa). These regiments exhibit a number of characteristics that an "ideal" anticoagulant should possess. Currently, two agents, dabigatran etexilate and rivaroxaban, which inhibit thrombin and FXa, respectively have been approved in the European Union and Canada for venous thromboprophylaxis in patients undergoing elective hip- or knee-replacement surgery. Other agents are at an early or late stage of clinical evaluation. In this study, we summarize the current evidence for these new developed or under development drugs regarding their applications in the filed of lower limb orthopaedic surgery.

Areas covered in this review: In this review, we present the classic approach of bioequivalence assessment, some situations of special importance such as the role of metabolites and highly variable drugs, and the current regulatory state in North America and Europe. Special emphasis is given to the methods proposed for solving the problems caused by high variability such as multiple-dose studies, replicate designs, individual bioequivalence and the widening of bioequivalence limits. Other issues discussed include the concept of biowaivers and the rising field of the equivalence of biologicals (biosimilars). What the reader will gain: The reader will gain an understanding of why bioequivalence assessment is necessary, how it is performed and what one should be aware of when planning to conduct a bioequivalence study. Take home message: The aim of bioequivalence studies is to ensure comparable in vivo performance of two drug products. This is accomplished by performing an appropriate clinical study which should be capable of ensuring the drug's safety and efficacy for consumers with less human exposure and costs of producing.

Summary form only given. Megawatt gyrotrons are found to suffer from various RF oscillations in the beam tunnel prior to the desired interaction zone (the cavity). The development of such parasitics degrades the beam quality reducing the efficiency of the cyclotron interaction and the overall produced power. Furthermore, it affects the stability of operation. Several design approaches have been implemented in order to suppress the parasitic modes; most of them involve the increase of the dissipation in the beam tunnel by means of lossy ceramic materials. However, despite the increased losses, parasitic oscillations still appear in several new designs, especially when the produced power and/or operating frequency is increased. In this work, we employ the numerical code FISHBONE, as well as the commercial simulation software CST STUDIO SUITE in order to study the parasitic modes which appear in a gyrotron beam tunnel. Furthermore, the effect of the geometry of the structure as well as the various design parameters on the parasitic modes is studied, in order to identify the origin and properties of the parasitic oscillations.

Dietary fat, both in terms of quantity and quality, has been implicated to cancer development, either positively or negatively. The aim of this work was to evaluate whether olive oil or monounsaturated fat intake was associated with the development of cancer. A systematic search of relevant studies, published in English, between 1990 and March 1, 2011, was performed through a computer-assisted literature tool (i.e., Pubmed). In total 38 studies were initially allocated; of them 19 case-control studies were finally studied (13800 cancer patients and 23340 controls were included). Random effects meta-analysis was applied in order to evaluate the research hypothesis. It was found that compared with the lowest, the highest category of olive oil consumption was associated with lower odds of having any type of cancer (log odds ratio = -0.41, 95%CI -0.53, -0.29, Cohran's Q = 47.52, p = 0.0002, I-sq = 62%); the latter was irrespective of the country of origin (Mediterranean or non-Mediterranean). Moreover, olive oil consumption was associated with lower odds of developing breast cancer (logOR = -0,45 95%CI -0.78 to -0.12), and a cancer of the digestive system (logOR = -0,36 95%CI -0.50 to -0.21), compared with the lowest intake. The strength and consistency of the findings states a hypothesis about the protective role of olive oil intake on cancer risk. However, it is still unclear whether olive oil's monounsaturated fatty acid content or its antioxidant components are responsible for its beneficial effects. © 2011 Psaltopoulou et al; licensee BioMed Central Ltd.

WHEN CITING: Patsantaras, N., & Kamberidou, I. (2011). Is Olympic Communication-Activity a Means for the Construction of Cosmopolitan Identities? In Sports, Bodies, Identities and Organizations: Conceptions and Problems (pp. 132–141). Wojciech J. Cunarski, Kazimierz Obodynski, Nicola Porro (Eds.). Publisher: Faculty of Physical Education, University of Rzeszow, under auspices of the European Association for Sociology of Sport (EASS). ISBN 978-83-7338-657-0. Copyright by Wydawnictwo Uniwersytetu Rzesowskiego Rzeszow 2011. ------------------------------------------------------------------------------------------------------------- Cultural Identity and Olympic Sports. In the last decades accelerated and unrestrained structural and institutional changes—on an institutional level— have been shattering significant cultural spheres such as class, gender, nationality, nation, and so forth. Today, due to social transformations individual/personal identities are changing and undermining, our sense of self as complete subjects. Namely, the social subject is losing his/her autonomy and self-sufficiency. Identity is no longer formulated on the basis of the social subject’s inner nucleus but is constructed in the interrelations of the self with the social values, meanings and symbols (culture) of the world in which we live and act in [Hall, Held, McGrew 1992]. Social identity is no longer focused on the self as the centre but on the social-cultural environment and as a result identities are being transformed due to structural and institutional changes.  The postmodern social subject, in this framework and as a rule, cannot have a stable, static or permanent identity. The social subject— athlete, individual as well as diverse social groups— is confronted with different representations according to socio-cultural conditions.  Olympic sports, as a relatively autonomous socio-cultural system, exercise a dynamic influence on the social subject— who acts and communicates within its structures— in the construction of personal/individual identities as well as collective identities. For example, since 1981 the changes that came about with the official recognition of the commercialization of Olympic activity, for some meant deviance and for others adaptation to transforming-evolving social processes.  Significant here are the changes regarding Olympic social reality— the material and structural conditions that influence the formation of identity— which affect the active participants as well as the passive ones. In our postmodern period, identities are continuously formed, transformed and reconstructed in relation to the ways that we are represented or addressed in the cultural system that surrounds us (Donnelly, Young 1988).   Keywords: globalization, cosmopolitanism, ecumenical values, collective identity, diverse identities, sport identity.

We propose to analyze ellipsometry data by using effective medium approximation (EMA) models. Thanks to EMA, having nanocrystalline reference dielectric functions and generalized critical point (GCP) model the physical parameters of two series of samples containing silicon nanocrystals, i.e. silicon rich oxide (SRO) superlattices and porous silicon layers (PSL), have been determined. The superlattices, consisting of ten SRO/SiO2 layer pairs, have been prepared using plasma enhanced chemical vapor deposition. The porous silicon layers have been prepared using short monopulses of anodization current in the transition regime between porous silicon formation and electropolishing, in a mixture of hydrofluoric acid and ethanol. The optical modeling of both structures is similar. The effective dielectric function of the layer is calculated by EMA using nanocrystalline components (nc-Si and GCP) in a dielectric matrix (SRO) or voids (PSL). We discuss the two major problems occurring when modeling such structures: (1) the modeling of the vertically non-uniform layer structures (including the interface properties like nanoroughness at the layer boundaries) and (2) the parameterization of the dielectric function of nanocrystals. We used several techniques to reduce the large number of fit parameters of the GCP models. The obtained results are in good agreement with those obtained by X-ray diffraction and electron microscopy. We investigated the correlation of the broadening parameter and characteristic EMA components with the nanocrystal size and the sample preparation conditions, such as the annealing temperatures of the SRO superlattices and the anodization current density of the porous silicon samples. We found that the broadening parameter is a sensitive measure of the nanocrystallinity of the samples, even in cases, where the nanocrystals are too small to be visible for X-ray scattering. Major processes like sintering, phase separation, and intermixing have been revealed as a function of annealing of the SRO superlattices. © 2010 Elsevier B.V. All rights reserved.

An expert panel convened to reach a consensus regarding the optimal use of lenalidomide in combination with dexamethasone (Len/Dex) in patients with relapsed or refractory multiple myeloma (RRMM). On the basis of the available evidence, the panel agreed that Len/Dex is a valid and effective treatment option for most patients with RRMM. As with other therapies, using Len/Dex at first relapse is more effective regarding response rate and durability than using it after multiple salvage therapies. Len/Dex may be beneficial regardless of patient age, disease stage and renal function, although the starting dose of lenalidomide should be adjusted for renal impairment and cytopenias. Long-term treatment until there is evidence of disease progression may be recommended at the best-tolerated doses of both lenalidomide and dexamethasone. Recommendations regarding the prevention and management of adverse events, particularly venous thromboembolism and myelosuppression, were provided on the basis of the available evidence and practical experience of panel members. Ongoing trials will provide more insight into the effects of continuous lenalidomide-based therapy in myeloma. © 2011 Macmillan Publishers Limited All rights reserved.

Chios mastic gum, the resin obtained as an exudate from the trunk and branches of Pistacia lentiscus L var. chia, is used extensively as a constituent of herbal drugs or functional foods. The oral absorption of its major constituents still remains unclear. In the context of identifying the features of mastic gum that are responsible for either therapeutic effects or effects of nutritional value, a methodology based on high-performance liquid chromatography (HPLC) coupled to tandem mass spectrometry (MS/MS) was developed and applied for the quantification of mastic gum triterpenic acids, 24Z-isomasticadienonic acid (IMNA), and 24Z-isomasticadienolic acid (IMLA) in mouse plasma. The specific compounds were selected based on their biological activity and potential against Helicobacter pylori. Concentrations were determined simultaneously in mouse plasma after oral administration of mastic gum or total mastic extract without polymer (TMEWP) in order to evaluate the role of the natural polymer, poly - myrcene, in the absorption process. Following TMEWP administration in mice, circulating IMNA and IMLA plasma levels were significantly higher (approximately 10-fold) in comparison to IMNA and IMLA plasma levels following total mastic gum administration (CMG), suggesting that the polymer plays a critical role in the absorption process. More specifically following TMEWP administration, Cmax plasma values were 3300±859ng/mL for IMNA and 163±58ng/mL for IMLA. In comparison, following CMG administration, Cmax plasma values were 329±57ng/mL for IMNA and 28±8ng/mL for IMLA. The methodological approaches presented in this study, along with the findings, offer valuable information on the availability of bioactive components following ingestion of mastic and facilitate the uses of mastic either as an ingredient of functional foods or as a herbal drug. © Georg Thieme Verlag KG Stuttgart - New York.

In Greece, there is no officially organized training in clinical chemistry for scientists. The Greek Society of Clinical Chemistry-Clinical Biochemistry decided to organize an intensive educational program of 18 seminars on clinical chemistry content as it is described in the EC4 Syllabus. The duration of each seminar was about 6 hours and consisted of 6 to 9 lectures. At the end of each seminar there was a voluntary written examination, comprised of 24 multiple choice questions. Successful completion of the Educational program was leading to a Certificate of Competence. Two cycles of the 18 seminars were performed: 1st cycle from October 2003 to December 2005 and 2nd cycle from March 2005 to October 2007. One hundred eighty nine colleagues was the mean attendance per seminar for the seminars of the 1st cycle and 38 colleagues for the seminars of the 2nd cycle. The mean participation to the examination for each seminar was almost 80% for the 1st cycle and 68% for the 2nd cycle. More than 80% of the participants performed Good or Very good in the examination in both cycles. It is estimated that more than 40% of the scientists who practice Clinical Chemistry in Greece, participated to this educational activity. This program is now provided as an e-learning application, and it is open for all scientists who want to follow the discipline of clinical chemistry.

BACKGROUND: Urothelial carcinoma of the upper urinary tract (UUT-UC) was a rare, aggressive urologic cancer with a propensity for multifocality, local recurrence, and metastasis. High-risk patients had poor outcomes. Because of the rarity of these tumors, randomized clinical trials and data regarding adjuvant chemotherapy in locally advanced tumors are currently unavailable. Our objective was to assess the effect of adjuvant chemotherapy and the impact of potential prognostic factors on survival in high-risk, postsurgical UUT-UC patients. METHODS: Using a multi-institutional, international retrospective database, identified were 627 patients with high risk UUT-UCs (pT3N0, pT4N0 and/or N+ and/or M+) who underwent surgical removal. Only patients who received adjuvant chemotherapy were included. RESULTS: Overall, 140 patients (22.6%) with a median age of 67 years were included. The median follow-up was 22.5 months. The 5-year, overall survival for the entire cohort was 43%, the 5-year recurrence-free survival was 54%, and metastasis-free survival was 53% at 5 years. Positive surgical margins were an independent prognostic factor for recurrence (P =.06), cancer-specific mortality (P =.05), and overall mortality (P =.02) of any cause. Adjuvant chemotherapy was not linked with overall or cancer-specific survival in patients with high risk disease (adjuvant chemotherapy [n = 140] vs no treatment [n = 487]) (P >.5). CONCLUSIONS: Adjuvant postoperative chemotherapy did not offer any significant benefit to overall survival in our population. Additional data were necessary, and studies enrolling patients at high risk in clinical trials investigating neoadjuvant chemotherapy in conjunction with chemotherapy should have been highly encouraged. Copyright © 2011 American Cancer Society.

Multiple myeloma, a plasma cell neoplasm, is the second most common hematologic malignancy after non-Hodgkins lymphoma and is responsible for 2% of cancer deaths. Melphalan and prednisone (MP) has been the standard treatment in elderly patients for many decades. The VISTA study evaluated the effect of this combination with or without the first-in-class proteasome inhibitor bortezomib in newly diagnosed myeloma patients who were not candidates for autologous stem cell transplantation. Altogether 682 patients were enrolled and prospectively randomized in this trial. All patients received nine 6-week cycles of oral melphalan (9 mg/m 2) and prednisone (60 mg/m 2) on days 1-4, either alone or with bortezomib administered intravenously (1.3 mg/m 2 on days 1, 4, 8, 11, 22, 25, 29 and 32 during the first four cycles and on days 1, 8, 22, 29 during remaining course of therapy). Median time to progression (the primary end point of the trial) was 24 months in the bortezomib-containing group compared with 16.6 months in the control group (p < 0.001). Response was evaluated in 337 patients receiving bortezomib compared with 331 patients in the control group who received MP alone; the percentages of partial response or better was 71 vs 35% (p < 0.001), with complete response seen in 30 vs 4%, respectively (p < 0.001). Median response duration in both groups was 19.9 versus 13.1 months, respectively. Median overall survival has not been reached in VMP group compared with 43 months in the MP group (p < 0.001), and this benefit is maintained after long term follow-up and subsequent antimyeloma therapies. Hematological adverse events (AEs) were similar in both groups, although patients in the bortezomib group experienced more frequent peripheral sensory neuropathy (including 13% grade 3, with less than 1% grade 4). Overall, the occurrence of grade 3 AEs was higher in patients receiving bortezomib (53 vs 44%, p = 0.02), but the risk of grade 4 AEs was identical (28 vs 27%). These results confirm the superiority of MP plus bortezomib combination over MP therapy in treatment-naive patients with newly diagnosed multiple myeloma who are ineligible for autologous stem cell transplantation. © 2011 Future Medicine Ltd.

Background: Randomized studies have shown that bevacizumab combined with taxane-based regimens increases response rates and prolongs progression-free survival (PFS) of patients with metastatic breast cancer (MBC). However predictive or prognostic biological markers that identify the appropriate target population, thus improving the cost-effectiveness ratio of this treatment, are still needed. Patients and Methods: Retrospectively, 124 patients with MBC treated either with paclitaxel 90 mg/m2 weekly x12 plus bevacizumab 10 μg/kg every 2 weeks or 15 μg/kg every 3 weeks (85 patients) or paclitaxel 175 mg/m2 plus bevacizumab 15 μg/kg every 3 weeks for 6 cycles (36 patients) were identified. Additionally, the prognostic significance of a panel of key biological markers was evaluated centrally by immunohistochemistry (IHC) in 88 evaluable patients. Results: More than two thirds of the patients completed chemotherapy, as planned. The response rate was almost identical (55.3% vs. 55.6%) in the patients treated with weekly or 3-weekly paclitaxel, respectively. After a median follow-up time of 23 months, the median PFS of the study population was 13 months, while median survival had not yet been reached. Common severe adverse events were neutropenia (33%), neuropathy (18.6%) and metabolic disturbances (17.6%). The incidence of hypertension of all grades was 28.1%. High expression of vascular endothelial growth factor (VEGF) receptor 3 (VEGFR3) was associated with clinical response, while high expression of VEGFR1 was associated with poor survival. Conclusion: The safety and activity of the combination of bevacizumab with paclitaxel given either weekly or 3-weekly in patients with MBC is confirmed.

Background: Paclitaxel (Taxol) and vinorelbine have shown synergism of cytotoxic effects in vitro and clinical activity in phase I and II studies. This combination was compared prospectively with the paclitaxel/gemcitabine regimen in non-operable non-small-cell lung cancer. Patients and methods: Chemotherapy-naive patients, stage IIIbwet and IV with performance status (0-1), were randomized to receive paclitaxel 200 mg/m2 on day 1 plus gemcitabine 1 gm/m2 (group A) on days 1 and 8 every 3 weeks or paclitaxel 80 mg/m2 plus vinorelbine 22.5 mg/m2 (group B) on days 1, 8 and 15 every 4 weeks. Results: A total of 398 out of 415 patients were eligible for analysis on intent-to-treat basis (group A: 196, group B: 202). Progression-free survival (PFS) was 5.0 months [95% confidence interval (CI) 4.3-5.6] and 4.4 months (95% CI 3.7-5.2) for groups A and B respectively (P = 0.365). Median survival was 11.1 months (95% CI 9.2-13.0) and 8.6 months (95% CI 7.0-10.2) for groups A and B respectively (P = 0.147). Grade 3/4 neutropenia and leukopenia were worse in group B (P < 0.001, in both cases). Febrile neutropenia and severe infections were more prominent (P < 0.001, P = 0.029 respectively) in group B. Conclusion: Although response rate, PFS and survival were non-different in both groups, toxicity was significantly worse in group B and therefore further investigation of P-Vin is of no value. © The Author 2010. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved.

Dispilio is a lakeside settlement by the Orestias Lake, Kastoria, northern Greece. The site was inhabited from the Middle Neolithic to the Chalcolithic, with some surface evidence of Bronze Age occupation. Microfacies analysis of the sediments, supported by a suite of environmental indices, has provided detailed paleoenvironmental data and elucidated the main processes involved in the formation of the site and its history of occupation. The settlement was established on the lakeshore, on a shallow sand ridge and a shore marsh. Initially, houses were built on raised platforms above the water. After a major conflagration, a range of depositional microenvironments were established that caused local changes in the sedimentation rate. Therefore, some areas quickly emerged and became dry land, while some others continued to be flooded as part of the transitional supra-littoral environment. On the dry land, houses were built directly on the ground, whereas in the transitional areas houses continued to be built on raised platforms. Thus, gradually, a mound was formed and further shaped by subsequent lake-level fluctuations. One of the lake-level rises is tentatively related to the abandonment of the mound in the Chalcolithic and the development of a hardpan on its surface. There is also evidence of later occupation during the Bronze Age in the form of a few, mostly surface, archaeological remains.

Background. Esophagogastroduodenoscopy (EGD) and colonoscopy (CS) can evoke anxiety, embarrassment, and discomfort. These concerns can culminate in panic attacks, which may traumatize patients and significantly decrease their compliance to the procedure. The objective of this study was to evaluate the relationship between preendoscopic anxiety and the possibility of a panic attack during an elective gastrointestinal endoscopy (EGE). Methods. The study population comprised of 79 Greek outpatients. The examination was carried out without the use of conscious sedation. Patients' anxiety levels were assessed before the procedure using the Greek version of the Spielberger State-Trait Anxiety Inventory (STAI-Y). Results. Seventy-nine patients were enrolled: 45 EGD and 34 CS. Females had higher state and trait anxiety levels than males (48.14 ± 7.94 versus 44.17 ± 7.43, P < 0.05; and 43.68 ± 6.95 versus 39.86 ± 7.46, P < 0.05). Patients who experienced panic attack had significantly higher levels of both trait and state anxiety, compared to those who were panic-free. There was no significant relationship between panic attacks and sex or type of procedure. Conclusions. Patients who experience panic attacks during endoscopic procedures appear to have significantly higher anxiety levels before the procedure. Administering the STAI questionnaire prior to the endoscopy seems to be a useful screening method for vulnerable patients.

Summary form only given. Coaxial cavity gyrotrons with axial corrugated insert are able to provide high-frequency microwave power in the MW region. The insert reduces the voltage depression and enhances the mode-selectivity of the cavity. Choosing the insert's radius and corrugation parameters properly, the parasitic modes are more easily suppressed. A major constraint in the design of such resonators is the heating of the structure due to the dissipation of part of the generated RF power of 2-3kW/cm2, whereas for the inner one this limit is up to ten times lower. The EU 2 MW, 170 GHz coaxial gyrotron cavity has been designed using the Surface Impedance Model (SIM) to calculate the ohmic loading of the insert. However, comparisons of SIM results with those obtained by the full-wave Space Harmonics Method (SHM) revealed significant discrepancies in the calculated ohmic loading. In this work, we perform a parametric study of the ohmic loading using SHM and SIM. Possible optimization, by means of minimization of ohmic losses and mode competition, of the EU coaxial gyrotron cavity is investigated.

{Cow's milk is one of the most common causes of food allergy. In two-thirds of patients, adverse symptoms following milk ingestion are caused by IgE-mediated allergic reactions, whereas for one-third, the mechanisms are unknown. Aim of this study was to investigate whether patients suffering from non-IgE-mediated cow's milk protein intolerance can be distinguished from persons without cow's milk protein intolerance based on serological measurement of IgG and IgA specific for purified cow's milk antigens.|We determined IgG(1-4) subclass and IgA antibody levels to purified recombinant αS1-casein, αS2-casein, β-casein, κ-casein, α-lactalbumin, and β-lactoglobulin in four patient groups by ELISA: Patients with IgE-mediated cow's milk allergy (CMA

Kamberidou, Irene (2011). PEACE EDUCATION: MOVING FORWARD THROUGH SPORT– ATHLETES UNITED FOR PEACE.  Chapter 6 (pp. 205-266) in  Gender, Social Capital, Multiculturalism & Sport by Irene Kamberidou published  in the Greek language. Publisher: Telethrio, Athens, Greece. [In  http://eudoxus.gr/ (academic publishers for students]

INTRODUCTION: Correlations between cephalometric measurements are frequently assumed to represent biologic associations. However, a significant portion of such correlations might arise from purely geometric dependencies, when measurements share common landmarks. Analytic calculation of this topographic component is difficult. The purpose of this study was to propose a permutation method for evaluating the topographic component of cephalometric correlations. METHODS: The method consisted of creating a virtual sample of cephalometric tracings (landmark configurations) from the original biologic sample under investigation. Each novel landmark configuration was constructed by assigning coordinates to the cephalometric points; the coordinates of each point were taken randomly from the original sample, each from a potentially different subject. Correlation analysis was performed separately on both samples and the results compared. Biologic meaning was ascribed only when there was a significant difference in correlation values between the samples. Confidence intervals for assessing statistical significance were calculated by using a randomization approach. The method was tested on a sample of 170 radiographs to evaluate the correlation between cranial base angle (NSBa) and angles SNA and SNB, as well as between ANB angle and the Wits appraisal. RESULTS: No biologic association was found between ANB and Wits, or between NSBa and SNA. The biologic correlation between NSBa and SNB was statistically significant but low (r(2) = 12%). CONCLUSIONS: Topographic associations between cephalometric measurements are ubiquitous and difficult to assess. The proposed method enables evaluation of their relative strength without the need for analytic solutions.

Most patients with newly diagnosed multiple myeloma (MM) are aged > 65 years with 30% aged > 75 years. Many elderly patients are also vulnerable because of comorbidities that complicate the management of MM. The prevalence of MM is expected to rise over time because of an aging population. Most elderly patients with MM are ineligible for autologous transplantation, and the standard treatment has, until recently, been melphalan plus prednisone. The introduction of novel agents, such as thalidomide, bortezomib, and lenalidomide, has improved outcomes; however, elderly patients withMM are more susceptible to side effects and are often unable to tolerate full drug doses. For these patients, lower-dose-intensity regimens improve the safety profile and thus optimize treatment outcome. Further research into the best treatment strategies for vulnerable elderly patients is urgently needed. Appropriate screening for vulnerability and an assessment of cardiac, pulmonary, renal, hepatic, and neurologic functions, as well as age > 75 years, at the start of therapy allows treatment strategies to be individualized and drug doses to be tailored to improve tolerability and optimize efficacy. Similarly, occurrence of serious nonhematologic adverse events during treatment should be carefully taken into account to adjust doses and optimize outcomes. © 2011 by The American Society of Hematology.

New CCD light curves of the recently detected eclipsing variable GSC 4589-2999 were obtained and analysed using the Wilson-Deninney code. Spectroscopic observations of the system allowed the spectral classification of the components and the determination of their radial velocities. The physical properties and absolute parameters of the components and an updated ephemeris of the system are given.

We present a detailed analysis of the optical modes and light propagation in photonic crystals consisting of chiral spheres in a nonchiral isotropic medium, calculated by the full electrodynamic layer-multiple-scattering method. It is shown that resonant modes of the individual spheres give rise to narrow bands that hybridize with the extended bands of the appropriate symmetry associated with light propagation in an underlying effective chiral medium. The resulting photonic dispersion diagrams exhibit remarkable features, peculiar to a system that possesses time-reversal but not space-inversion symmetry, which are analyzed in terms of group theory. In particular, we reveal the occurrence of strong band bending away from the Bragg points with consequent negative-slope dispersion inside the first Brillouin zone, slow-photon bands, and frequency gaps. The calculated band structure is discussed in conjunction with relevant reflection diagrams, providing a consistent interpretation of the underlying physics.

We report on the occurrence and properties of photonic surface states in fcc crystals of metallic nanoshells, by means of full-electrodynamic calculations using the layer-multiple-scattering method, properly extended. Detailed dispersion diagrams of the surface states associated with the (001)  and (111)  surfaces are calculated for such semi-infinite crystals and corresponding finite slabs, and convergence by increasing the slab thickness is discussed. It is shown that these states can be tuned over a broad frequency range by varying the shell thickness and can be characterized, along high-symmetry directions, according to their symmetry. Absorption in the metallic material limits the propagation length which can, however, be as long as several tens of lattice constants for low-loss metals and relatively broad bands.

Periodic media offer impressive opportunities to manipulate the transport of classical waves namely light or sound. Elastic waves can scatter light through the so-called acousto-optic interaction which is widely used to control light in telecommunication systems and, additionally, the radiation pressure of light can generate elastic waves. Concurrent control of both light and sound through simultaneous photonic-phononic, often called phoxonic, bandgap structures is intended to advance both our understanding as well as our ability to manipulate light with sound and vise versa. In particular co-localization of light and sound in phoxonic cavities could trigger nonlinear absorption and emission processes and lead to enhanced acousto-optic effects. In the present communication, we present our efforts towards the design of different phoxonic crystal architectures such as three-dimensional metallodielectric structures, two-dimensional patterned silicon slabs and simple one-dimensional multilayers, and provide optimum parameters for operation at telecom light and GHz sound. These structures can be used to design phoxonic cavities and study the acousto-optic interaction of localized light and sound, or phoxonic waveguides for tailored slow light-slow sound transport. We also discuss the acousto-optic interaction in onedimensional multilayer structures and study the enhanced modulation of light by acoustic waves in a phoxonic cavity, where a consistent interpretation of the physics of the interaction can be deduced from the time evolution of the scattered optical field, under the influence of an acoustic wave.

OBJECTIVES: To examine the association between physical activity (PA) and Alzheimer disease (AD) course. BACKGROUND: PA has been related to lower risk for AD. Whether PA is associated with subsequent AD course has not been investigated. METHODS: In a population-based study of individuals aged 65 years and older in New York who were prospectively followed up with standard neurologic and neuropsychological evaluations (every ~1.5 years), 357 participants i) were nondemented at baseline and ii) were diagnosed with AD during follow-up (incident AD). PA (sum of participation in a variety of physical activities, weighted by the type of activity [light, moderate, and severe]) obtained 2.4 (standard deviation [SD], 1.9) years before incidence was the main predictor of mortality in Cox models and of cognitive decline in generalized estimating equation models that were adjusted for age, gender, ethnicity, education, comorbidities, and duration between PA evaluation and dementia onset. RESULTS: One hundred fifty incident AD cases (54%) died during the course of 5.2 (SD, 4.4) years of follow-up. When compared with incident AD cases who were physically inactive, those with some PA had lower mortality risk, whereas incident AD participants with much PA had an even lower risk. Additional adjustments for apolipoprotein genotype, smoking, comorbidity index, and cognitive performance did not change the associations. PA did not affect rates of cognitive or functional decline. CONCLUSION: Exercise may affect not only risk for AD but also subsequent disease duration: more PA is associated with prolonged survival in AD.

In recent years, significant changes in precipitation regimes have been observed and these manifest in socio economic and ecological problems especially in regions with increased vulnerability such as the Mediterranean region. For this reason, it is necessary to estimate the future projected precipitation on short and long-term basis by analyzing long time series of observed station data. In this study, an effort was made in order to forecast the monthly maximum, minimum, mean and cumulative precipitation totals within a period of the next four consecutive months, using Artificial Neural Networks (ANNs). The precipitation datasets concern monthly totals recorded at four meteorological stations (Alexandroupolis, Thessaloniki, Athens, and Patras), in Greece. For the evaluation of the results and the ability of the developed prognostic models, appropriate statistical indexes such as the coefficient of determination (R2), the index of agreement (IA) and the root mean square error (RMSE) were used. The findings from this analysis showed that the ANN's methodology provides satisfactory precipitation totals in four consecutive months and these results are better results, than those obtained using classical statistical methods. A fairly good consistency between the observed and the predicted precipitation totals at a statistical significance level of p < 0.01 for the most of the examined cases has been revealed. More specifically, the Index of Agreement (IA) ranges between 0.523 and 0.867 and the coefficient of determination (R2) ranges between 0.141 and 0.603. The most accurate forecasts concern the mean monthly and the cumulative precipitation for the next four consecutive months. © 2011 Springer Science+Business Media B.V.

OBJECTIVE: Insomnia is frequently underrecognized in medical wards; therefore, we assessed the prevalence and explored medical and psychological variables associated with insomnia. METHOD: The Athens Insomnia Scale and the Hospital Anxiety and Depression Scale (HADS) were completed in 235 inpatients along with demographic data, admission diagnosis, lifetime psychiatric diagnosis and prescribed psychotropics. RESULTS: The overall insomnia prevalence was 37%. Logistic regression showed that HADS anxiety and depression cases and patients with infections were more likely to have insomnia (OR 24.2, 6.1 and 5.4, respectively). CONCLUSIONS: Patients with depressive and mainly anxiety symptoms are more likely to experience insomnia in medical wards. Patients with infections are also likely to have insomnia, independently of depressive and anxiety symptoms, and appropriate interventions should be applied.

The main objective of the present study is to perform a trend analysis and investigate the possible changes in the frequency and wind intensity of the Etesians during June to September of the years 1979 to 2009. The analysis is based mainly on the use of Reanalysis-1 data from the National Centers for Environmental Prediction/National Center for Atmospheric Research. The results are indicative of negative trends in the frequency and wind speed (WS) of the Etesians. During the 31-year period studied, the total number of Etesian days from June to September decreased by about 4.6 days, while the monthly maximum intensity of the daily WS was reduced by almost 1 m s-1. The above indications are strengthened by similar results derived from the trend analysis of observational wind data in the central Aegean for the years 1955 to 2002. The negative trend in the frequency of the Etesian days could be explained by a decreasing trend in the pressure gradient between the central and southern Europe high-pressure center and the Middle East low-pressure center, which cause the Etesians system. In the study, a possible association between the Southern Oscillation and the Etesian winds is also revealed. The negative trend in the frequency and WS of the Etesian winds could imply a reduced cooling mechanism in the eastern Mediterranean in the summer period due to climate change. © 2011 Springer-Verlag.

Primary systemic immunoglobulin light chain amyloidosis (AL) results from the accumulation of amyloid fibrils that are composed of a monoclonal immunoglobulin light chain that is produced by a plasma cell clone. Almost every organ can be involved, resulting in multisystemic symptoms and signs. Diagnosis may be difficult and requires a certain degree of suspicion. Treatment is challenging and most patients may be quite frail. Careful assessment of the organ involvement and prognosis is needed before planning the treatment strategy. Supportive care is critical for AL patients. The goal of treatment is the reduction of light chain production. Conventional chemotherapy may be effective and recently introduced novel agents expand treatment options in patients who relapse or are not candidates for high-dose melphalan with autologous stem cell transplant (HDM-ASCT). In experienced centers, HDM-ASCT in patients deemed capable of tolerating the procedure is associated with high response rates with modest treatment-related mortality. © 2011 Blackwell Publishing Ltd.

We reexamined the total extinction along the sightline of a quasar (J004457+4123) behind the disk of M31 and used a varying total-to-selective extinction ratio in order to obtain a better agreement between its optical spectrum and a composite SDSS spectrum based on input spectra of quasars from DR7 at similar redshifts. The M31 outermost disk predominates (~85%) the total foreground (Milky Way+M31) selective extinction EB-V = 0.30+/-0.05 mag and the derived gas-to-dust ratio is N(H)/EB-V = (3.5+/-0.7)×1020 atcm-2 mag-1.

The management of patients with AL requires meticulous risk assessment in order to plan treatment strategy and reduce the risk of treatment related complications. The most important prognostic feature and poor risk factor is amyloidotic involvement of the heart. Traditional techniques, such as ultrasonography provide significant information on the severity of cardiac amyloidosis, however cardiac biomarkers (cardiac Troponins and NTproBNP) are simpler to perform, are available in almost every lab or as a bedside test, are noninvasive, have reasonable cost, and are powerful predictors of outcome and assess the risk of treatment related complications (especially early death) in patients considered for autologous transplantation. Refinement of cardiac biomarker-based prognostic system with additional markers may help identify subgroups of patients at special risk. Additional markers could also help assess the risk of renal or liver damage or autonomic dysfunction and could help improve management. There are no formal guidelines for the management of AL patients based on risk stratification systems; however, recommendations have been published and current evidence supports the use of cardiac biomarkers as a helpful guide to treatment strategy.© 2011 Informa UK, Ltd.

Objective: Early-stage epithelial ovarian cancer represents a prognostically heterogenous group. We studied prognostic factors in patients treated with adjuvant paclitaxel/carboplatin chemotherapy. Methods: Data was extracted from 147 patients with FIGO stage IA/IB, grade 2/3 or stage IC/IIA (any grade) who underwent primary surgery followed by paclitaxel/carboplatin chemotherapy. Results: Median follow-up was 88 months. Ten-year relapse-free (RFS) and disease-specific survival (DSS) were: 81% (95% confidence interval [CI]: 73-89) and 81% (95% CI: 73-89). On multivariate analysis, non serous histology was associated with reduced risk for RFS (0.294, 95% CI: 0.112-0.577, p = 0.001) and DSS (0.194, 95% CI: 0.075-0.504, p = 0.001), while high-risk category (stage IC/IIA and grade 2/3) with increased risk for RFS (3.989, 95% CI: 1.189-13.389, p = 0.009) and DSS (3.989, 95% CI: 1.064-16.386, p = 0.038). The combination of histology and grade identified 3 groups with distinctly different 10-year RFS and DSS rates (p < 0.001): grade 1 (100% and 100%), non-serous grade 2/3 (83% and 86%) and serous grade 2/3 (60% and 60%). Conclusions: Serous histology is an adverse prognostic factor in early-stage ovarian cancer treated with adjuvant paclitaxel/carboplatin. Risk stratification according to histology and grade is a useful discriminator of prognosis and can be used in the design of future studies. © 2011 Elsevier Inc. All rights reserved.

Waldenström's macroglobulinemia is characterized by a protracted course in most patients and the median survival may be long. However, a subset of patients may present with more aggressive disease that is associated with short survival. In order to better characterize these "poor-risk" patients, we identified patients who died within 2 years from the initiation of front-line treatment. These patients were older and had more often features of aggressive disease, such as elevated LDH and low serum albumin than the standard-risk population. Furthermore, only a minority of poor-risk patient had a response to initial therapy. However, conventional clinical factors or even the lack on response could not adequately identify poor-risk patients, indicating the need for novel molecular or other markers that would be able to effectively recognize patients at greatest need for aggressive therapies. © 2011 Elsevier Inc. All rights reserved.

There is a wide variety in the appearance of normal female external genitalia. Nevertheless a specific prototype is promoted by the media, leading to a false sense that all other appearances are abnormal. As adolescents become sexually aware at an earlier age, most of them are worried about the appearance of their genitalia, especially when labia minora protrude beyond labia majora. This is a prospective audit of adolescents presenting for assessment of their perceived abnormal genitalia. Sixteen girls aged 10.2 to 17.8 years presented between June 2009 and December 2010 to a specialist adolescent gynecology service. Their mean labial width was 36 mm (range: 2055 mm). In six girls, the reason for attending the service was inequality of the size of labia ranging between 6 mm and 35 mm (mean of 20 mm). Among the remaining 10 girls, the concern had arisen through comparison with a prepubescent sibling (one case), change of genitalia during puberty (four cases), looking at internet pictures (four cases), and looking at an anatomy book (one case). Risks of Female Genital Cosmetic Surgery (FGCS) have not been adequately documented, especially with regards to sexual function and long-term patient satisfaction. External genitalia are likely to change during puberty and therefore, any genital operation in the absence of clear pathology should be deferred until adulthood. Even then, women should have clear expectations of what will be achieved with the operation in terms of appearance and function. © 2011 Informa UK, Ltd.

Between 2004 and 2009, 60 patients with proximal tibial fractures were included in this prospective study. All fractures were treated with the polyaxial locked-plate fixation system (DePuy, Warsaw, IN, USA). Clinical and radiographic data, including fracture pattern, changes in alignment, local and systemic complications, hardware failure and fracture union were analysed. The mean follow-up was 14 (12-36) months. According to the Orthopaedic Trauma Association (OTA) classification, there were five 41-A, 28 41-B and 27 41-C fractures. Fractures were treated percutaneously in 30% of cases. Double-plating was used in 11 cases. All but three fractures progressed to union at a mean of 3.2 (2.5-5) months. There was no evidence of varus collapse as a result of polyaxial screw failure. No plate fractured, and no screw cut out was noted. There was one case of lateral joint collapse (>10°) in a patient with open bicondylar plateau fracture. The mean Knee Society Score at the time of final follow-up was 91 points, and the mean functional score was 89 points. The polyaxial locking-plate system provided stable fixation of extra-articular and intra-articular proximal tibial fractures and good functional outcomes with a low complication rate.

In a previous paper ([1]), we associated a holonomy groupoid and a C*-algebra to any singular foliation (M,ℱ). Using these, we construct the associated pseudodifferential calculus. This calculus gives meaning to a Laplace operator of any singular foliation ℱ on a compact manifold M, and we show that it can be naturally understood as a positive, unbounded, self-adjoint operator on L2(M).

Στον τόμο αυτό περιέχονται επιλεγμένες εργασίες που παρουσιάστηκαν στο Πανελλήνιο Συνέδριο "Ιστορία, Φιλοσοφία και Διδακτική των Επιστημών", το οποίο έγινε στην Αθήνα από τις 5 έως και τις 10 Μαΐου 2010, υπό την επιστημονική εποπτεία της Ελληνικής Εταιρεία Ιστορίας, Φιλοσοφίας και Διδακτικής των Επιστημών - ΕΕΙΦΔΕ. Οι βασικοί θεματικοί άξονες του Συνεδρίου στόχευαν στο να δοθεί βήμα στην πρωτογενή έρευνα που διεξάγεται στην Ελλάδα στους τομείς επιστημονικής δραστηριοποίησης της Ελληνικής Εταιρείας Ιστορίας, Φιλοσοφίας και Διδακτικής των Επιτημών. Συγκεκριμένα, οι εργασίες που περιλαμβάνονται στον παρόντα τόμο άπτονται θεμάτων Ιστορίας της Επιστήμης και της Διδακτικής, Φιλοσοφίας της Επιστήμης, Κοινωνιολογίας της Επιστήμης, Θεωρίας και Πράξης της Διδακτικής, Συγκρότησης της Επιστήμης της Διδακτικής, Διδακτικής Μεθοδολογίας.

The aim of the present study was to examine the psychometric properties of the Test of Performance Strategies-Competition scale (TOPS-CS; Thomas et al., 1999) in Greek athletic population. The TOPS-CS was designed to assess eight psychological strategies used by athletes in competition (activation, automaticity, emotional control, goal-setting, imagery, negative thinking, relaxation and self-talk). In order to evaluate the psychometric properties of the inventory, two different research studies were conducted in two different age groups (n1=382 athletes, aged 16 to 20 years and n2=343 athletes, aged 12 to 15 years). Furthermore, 263 athletes, (aged 16 to 20 years) completed the TOPS-CS, purposing to perform confirmatory factor analysis. The results of the first study supported the initial factorial structure of the TOPS-CS for athletes aged 16-20 years. Reliability analysis also provided adequate evidence for the internal consistency and stability of the scale for Greek athletes of this age. However, for athletes aged 12 to 15 years, the validity and reliability of the inventory were questionable and further research is required. © Editorial Committee of Journal of Human Kinetics.

The effects of the geological, tectonic and neotectonic structure and the impact of the human presence and activity on the drainage network of Pineios river are presented here in order to determine the causes of its diversion and the implications to the shoreline. We used, analyzed and evaluated (a) geomorphological, geological, tectonic and neotectonic data of the study area, (b) historical information and archaeological findings from buried and eroded archaeological sites of the wider study area, (c) published data related to drill cores and radiocarbon dates, and (d) remote sensing datasets, as satellite and aerial photos of different capturing periods, as well as real-time kinematic differential GPS measurements for the definition of the current shoreline. It is concluded that the detected shoreline displacements and drainage diversions are the result of the combination of active tectonics and human activity during the last 100 kyrs.

Human kallikrein-related peptidase 14 gene (KLK14) is regulated by androgens and progestins. This gene is expressed in the central nervous system and endocrine tissues such as the breast, prostate and ovary. The differential KLK14 mRNA expression levels are related to several human neoplasias, among them breast cancer. The aim of this study was to analyse the KLK14 expression in breast tissues and to investigate its differential diagnostic and prognostic value in the mammary carcinomas. For this purpose, we isolated total RNA from 70 malignant and 33 benign specimens. After testing RNA quality, we synthesised cDNA by reverse transcription and applied a highly sensitive quantitative real-time PCR (qRT-PCR) method for KLK14 mRNA quantification using the SYBR Green(R) chemistry. HPRT1 was used as a reference gene and the BT20 breast cancer cell line as a calibrator. Relative quantification analysis was performed using the comparative CT method 2-DeltaDeltaCT. KLK14 expression was detected in both types of breast tumours. However, a statistically significant increase of the KLK14 mRNA level was observed in the malignant, compared to the benign tumour samples (p<0.001), highlighting its value in discriminating these breast lesions. Elevated KLK14 expression profiles were associated with higher tumour grade (p=0.043) and size (p=0.007) in cancerous samples. Furthermore, KLK14 mRNA expression showed negative correlation in a statistically significant manner with estrogen receptor status (p=0.024). In accordance with logistic regression models (p=0.012) and receiver-operating-characteristics analysis (p<0.001), KLK14 gene expression could be evaluated as a putative independent diagnostic biomarker in breast tumour biopsies.

Background: Colon cancer is a public health problem worldwide. Adjuvant chemotherapy after surgical resection for stage III colon cancer has been shown to improve both progression-free and overall survival, and is currently recommended as standard therapy. However, its value for patients with stage II disease remains controversial. When this study was designed 5-fluorouracil (5FU) plus leucovorin (LV) was standard adjuvant treatment for colon cancer. Irinotecan (CPT-11) is a topoisomerase I inhibitor with activity in metastatic disease. In this multicenter adjuvant phase III trial, we evaluated the addition of irinotecan to weekly 5FU plus LV in patients with stage II or III colon cancer.Methods: The study included 873 eligible patients. The treatment consisted of weekly administration of irinotecan 80 mg/m2intravenously (IV), LV 200 mg/m2and 5FU 450 mg/m2bolus (Arm A) versus LV 200 mg/m2and 5FU 500 mg/m2IV bolus (Arm B). In Arm A, treatments were administered weekly for four consecutive weeks, followed by a two-week rest, for a total of six cycles, while in Arm B treatments were administered weekly for six consecutive weeks, followed by a two-week rest, for a total of four cycles. The primary end-point was disease-free survival (DFS) at three years.Results: The probability of overall survival (OS) at three years was 0.88 for patients in Arm A and 0.86 for those in Arm B, while the five-year OS probability was 0.78 and 0.76 for patients in Arm A and Arm B, respectively (P = 0.436). Furthermore, the probability of DFS at three years was 0.78 and 0.76 for patients in Arm A and Arm B, respectively (P = 0.334). With the exception of leucopenia and neutropenia, which were higher in patients in Arm A, there were no significant differences in Grades 3 and 4 toxicities between the two regimens. The most frequently recorded Grade 3/4 toxicity was diarrhea in both treatment arms.Conclusions: Irinotecan added to weekly bolus 5FU plus LV did not result in improvement in disease-free or overall survival in stage II or III colon cancer, but did increase toxicity.Trial registration: Australian New Zealand Clinical Trials Registry: ACTRN12610000148077. © 2011 Papadimitriou et al; licensee BioMed Central Ltd.

Background in Ancient Greek Music Theory and Philosophy. The foundation of musicology as agenuine discipline with a clear-cut subject matter and a well-defined terminology can be traced backto the writings of Aristoxenus of Taras, a pupil of Aristotle. However, its epistemological roots in harmonicsand origin in Pythagorean philosophy reach back until the 6th century. Ad interim the developmentof a melodic notation system acted as a crucial factor to grow musicology into a ̔science’ oflogical reasoning. Interestingly, and still without satisfactory explanation, notation as an adequatemedium of music was brusquely rejected by Aristoxenus.Background in Music Technology and Signal Processing. Besides the thought-provoking fact thatsignal processing as the foundation of modern music technology itself originates from the domain ofharmonic analysis and, similarly, became relevant to ̔musicology proper’ only by extension with adiscrete agency purely logic in nature—i.e. the computer—now, real-time pitch-tracking andpitch-shifting can be used to augment ancient instruments electronically in order to pose archaeologicalquestions and challenge sedimented hermeneutical interpretations.Aims. While re-enacting historical configurations, applied media theory provides an unconventionalframework to interlink both backgrounds anachronistically. In practice, the aim of the present interdisciplinaryapproach is to take issue with common exegeses of the rise of ancient Greek music theory,deliver testable hypotheses to corroborate a modified picture and finally to overcome the outdatedantithesis of Pythagorean vs. Aristoxenian views on music—i.e. numerology vs. phenomenology—propounded since the Hellenistic Period and still prevalent today.Main contribution. The historical background and epistemological circumstances that led to theformation of musicology as a separate field of knowledge are reviewed. During the course of discussiona "pre-Aristoxenian codec of notation" is uncovered and linked with scattered references to thebarbiton-lyre. The acoustical significance of its origin becomes ̔instrumental’ to augment a self-madereconstruction of such an instrument electronically. Hereby a perceptual model of melody isre-enacted that logically connects and unifies theoretical camps previously considered irreconcilable.The technology and methodology necessary to achieve this is described.Implications. Towards the end of the 5th century, many sources ascribe a revolutionary ̔new music’to the advent of frequent modulations and different ̔styles’ of playing techniques. Taking this revolutionseriously, the present paper constructs a history of hearing that proposes a rupture in the ancientGreek sonosphere. Accordingly, the changed strategy of listening is regarded the true cause of theAristoxenian separation of musicology. Today, the ̔kernel’ of this parting can be identified with themore general domain of "time-critical processes" in computation and signal processing whose applicationenables us to understand the subsequent reshaping of music theory and the radical remodellingof its philosophical conception. By extension, this lesson in mousikḗ may make us rethink music asstill a vital epistemological field and may encourage us to form a new research domain possibly calledcomputational archaeomusicology.

Abstract Renal impairment (RI) is a common presenting complication of multiple myeloma associated with significant morbidity and early mortality, while it has been associated with inferior survival in patients treated with conventional regimens. We assessed the impact of RI in 203 unselected consecutive patients treated upfront with novel agents (thalidomide, lenalidomide, bortezomib). RI was assessed by the estimated glomerular filtration rate (eGFR). RI (eGFR <60 mL/min) was present in 93 (45.8%) of patients at diagnosis and was associated with advanced age, advanced International Staging System (ISS) stage, poorer performance status, hypercalcemia, urine Bence-Jones proteinuria, anemia and thrombocytopenia. Myeloma response rates were similar for patients with or without RI. In univariate analysis RI was associated with shorter survival and a higher rate of early death (7% vs. 3.5%); however, when adjusted for other prognostic factors, RI was not independently associated with survival. In conclusion, in unselected newly diagnosed patients treated with novel agent-based therapies, RI is not independently associated with inferior survival, probably due to the significant activity of novel agents even in the context of RI.

To investigate the mechanisms of the therapeutic action and drug resistance to the nitrogen mustard melphalan, melphalan-induced DNA damage repair and chromatin structure were examined along the p53, N-ras and d-globin gene loci in cells carrying different repair activities. In nucleotide excision repair-deficient XP-A cells, similar levels of adducts were found in all fragments examined, indicating uniform distribution of DNA damage. In both, repair-proficient CS-B and XP-C cells, faster repair was observed in regions inside the transcribed N-ras and p53 genes, compared to regions on both sides outside of the genes, while no such difference was observed for the inactive d-globin gene. Moreover, very fast adduct repair on the transcribed strand of the active genes was seen immediately downstream of the transcription start site, together with a steeply decreasing gradient of repair efficiency along the gene towards the 3'-end. In all cells analyzed, the above variation in DNA repair efficiency was paralleled exactly by the variation in the degree of local chromatin condensation, more relaxed chromatin being associated with faster repair. Similar results were obtained using peripheral blood mononuclear cells from healthy volunteers, suggesting that the existence of a repair gradient along transcribed genes may be a universal phenomenon. In conclusion, these findings demonstrate that the repair of melphalan adducts in the transcribed strand of active genes is subject to a strong polarity effect arising from variations in the chromatin structure. © 2011 Elsevier B.V.

Objectives: Stage I testicular nonseminomatous germ-cell tumors (NSGCT) are highly curable. Following orchidectomy surveillance, adjuvant chemotherapy and retroperitoneal lymph node dissection can be applied. Certain factors are used to select patients in high-risk for relapse. We report the outcome and safety of a risk-adapted strategy by the Hellenic Cooperative Oncology Group. Methods: Between 1994 and 2004, 142 patients with stage I NSGCT and 1 of the following risk factors: lymphovascular invasion (LVI), invasion of tunica vaginalis, spermatic cord, rete testis or scrotal wall, embryonal component >50% of the total tumor, were prospectively included in a protocol of adjuvant chemotherapy consisting of two 3-week courses of bleomycin 15 IU, etoposide 120 mg/m2, and cisplatin 40 mg/m2 for 3 consecutive days with G-CSF support. Results: Median follow-up was 79 months and 138 patients have been followed for at least 2 years. Seventy-seven patients (54%) had LVI and 74 (52%) had >50% embryonal component. There was 1 relapse, which was cured with chemotherapy and surgery. Another patient died due to disease-unrelated causes and 1 patient developed a new primary of the remaining testicle, which was cured with surgery. Conclusion: Two cycles of bleomycin/etoposide/cisplatin is an effective and safe form of adjuvant therapy in high-risk stage I NSGCT. © 2011 Elsevier Inc.

Differences in ecological conditions can result in the evolution of dramatic inter-population shifts in whole suites of traits. We studied variation in reproductive output in three lizard populations of the Skyros Wall Lizard (Podarcis gaigeae, Lacertidae) endemic to the Skyros Archipelago (Greece), which live under similar climatic conditions but differ in predation pressure and food availability. Based on the ‘‘island syndrome’’ hypothesis, we predicted that females from island populations would produce larger, but fewer offspring. The study populations differ conspicuously in average body size, with males from the satellite Lakonissi and Diavates islets being respectively 20% and 39% larger than males from the main Skyros Island. Lizards from these predator-free islets produced eggs of larger size than the main Skyros population; however, they also produced significantly larger clutches than the Skyros population (2.31±0.83 and 2.73±1.0 vs. 1.97±0.58 eggs). All inter-population differences in clutch size, clutch volume, and egg size were explained by corresponding differences in average body size of the dams, revealing that across all populations, reproductive effort scaled similarly with maternal body size. There was no evidence of trade-offs between egg size and clutch size as generally encountered in many reptile taxa. The occurrence of this unusual pattern of reproductive investment among islet populations of giants is probably best explained by the occurrence of two underlying drivers: first, the substantial marine subsidies by resident seabird colonies and second, the existence of intense cannibalistic behaviors in the form of attacks to the tail and severe intraspecific predation on juveniles. This suggests that subsidies-driven gigantism in island endemics may free species from such trade-offs and allow a population to maximize reproductive output in multiple, normally conflicting dimensions.

Aim.?Postpartum mood disturbances are common among Greek women, with postpartum depression (PPD) being as high as 19%. This study aimed to investigate whether sex steroid hormone levels affect the incidence of postpartum mood disturbances. Materials and methods.?Fifty-seven women were evaluated for postpartum mood disturbances using the Postpartum Blues Questionnaire and the Edinburgh Postnatal Depression Scale on the 1st and 6th week. Serum estradiol, progesterone and testosterone concentrations were measured upon admission for delivery and daily until the fourth postpartum day. We then studied the association between hormone levels and the scores in the two psychometric scales. Results.?Testosterone was the only hormone that was marginally associated with psychometric scoring in simple regression analysis. (Postpartum Blues during days 14: b = 4.291, 95% C.I. -0.796 to 9.377 and p-value = 0.096). Women with lower testosterone drops had higher scores in Postpartum Blues Questionnaire. This association, however, lost statistical significance in the multivariable analysis after adjusting for pregnancy duration. In multiple regression analysis, only pregnancy duration had the most constant adverse effect on psychometric scores: The shorter the duration of pregnancy, the higher the scores for Postpartum Blues. (r = -0.39, p < 0.01). Conclusions.?Our findings do not indicate an association between the occurrence of postpartum mood disorders and sex steroid hormone levels. Preterm labour may be associated with a higher risk of postpartum mood disturbances. © 2010 Informa UK Ltd.

Successful research management requires multifunctional, equal teamwork and efficient coordination, aiming to increase the impact of the research outcomes. Aim of this paper is to present the strategies that have been followed to successfully manage the RN4CAST study, one of the largest multi country research projects ever conducted. The paper focuses on the core research strategies rather than on the administrative management activities also required for the success of this case report. Management of a multi-country nursing survey requires the use of common data collection tools, applicable to every context, research protocols supporting the scope of the research, data models for multi-country analyses and global dissemination strategies.

Objectives: This subanalysis of the phase 3 VISTA trial aimed to assess the frequency, characteristics and reversibility of, and prognostic factors for, bortezomib-associated peripheral neuropathy (PN) in newly diagnosed patients with multiple myeloma ineligible for high-dose therapy who received bortezomib plus melphalan-prednisone.Methods: Patients received nine 6-wk cycles of VMP (bortezomib 1.3 mg/m2, days 1, 4, 8, 11, 22, 25, 29, 32, cycles 1-4, and days 1, 8, 22, 29, cycles 5-9; melphalan 9 mg/m2, days 1-4, cycles 1-9; and prednisone 60 mg/m2, days 1-4, cycles 1-9).Results: Overall, 47% of patients receiving VMP developed PN, including 19% grade 2 and 13% grade ≥3 (<1% grade 4). The PN incidence was dose-related and reached a plateau at a cumulative bortezomib dose of approximately 45 mg/m2. Median time to PN onset was 2.3 months. Bortezomib-associated PN was reversible; 79% of events improved by at least one NCI CTCAE grade within a median of 1.9 months and 60% completely resolved within a median of 5.7 months, with reversibility similar in responding and non-responding patients. By multivariate analysis, baseline neuropathy was the only consistent risk factor for any PN [hazard ratio (HR) 1.785, P = 0.0065], grade ≥2 PN (HR 2.205, P = 0.0032), and grade ≥3 PN (HR 2.438, P = 0.023); age, pre-existing diabetes, International Staging System stage, obesity, and creatinine clearance did not affect the overall rate of PN.Conclusions: Rates of bortezomib-induced PN in the frontline setting were similar to those in relapsed patients and resolved in most cases. (Clinicaltrials.gov identifier: NCT00111319). © 2010 John Wiley & Sons A/S.

European legislators and wine producers still debate on the requirement for labeling of wines fined with potentially allergenic food proteins (casein, egg white or fish-derived isinglass). We investigated whether wines fined with known concentrations of these proteins have the potential to provoke clinical allergic reactions in relevant patients.|In-house wines were produced for the study, fined with different concentrations of casein (n = 7), egg albumin (n = 1) and isinglass (n = 3). ELISA and PCR kits specific for the respective proteins were used to identify the fining agents. Skin prick tests and basophil activation tests were performed in patients with confirmed IgE-mediated relevant food allergies (n = 24). A wine consumption questionnaire and detailed history on possible reactions to wine was obtained in a multinational cohort of milk, egg or fish allergic patients (n = 53) and patients allergic to irrelevant foods as controls (n = 13).|Fining agents were not detectable in wines with the available laboratory methods. Nevertheless, positive skin prick test reactions and basophil activation to the relevant wines were observed in the majority of patients with allergy to milk, egg or fish, correlating with the concentration of the fining agent. Among patients consuming wine, reported reactions were few and mild and similar with the ones reported from the control group.|Casein, isinglass or egg, remaining in traces in wine after fining, present a very low risk for the respective food allergic consumers. Physician and patient awareness campaigns may be more suitable than generalized labeling to address this issue, as the latter may have negative impact on both non-allergic and allergic consumers.

Objective: We investigated the efficacy of risk-adapted adjuvant paclitaxel/carboplatin chemotherapy in early-stage ovarian carcinoma. Methods: Fifty-three patients were treated according to the risk of relapse: patients with stages IA or IB or with grade 1 (low risk) received 4 cycles of paclitaxel and carboplatin; patients with IC/IIA and grade 2 or 3 (high risk) received 6 cycles of chemotherapy. The outcome was compared with that of 95 patients who were all treated with 4 cycles. Results: Median follow-up was 88, 113 and 42 months for the whole cohort, non-risk-adapted and risk-adapted treatment, respectively. Five-year relapse-free and diseasespecific survival was 86 and 93% for the whole population, 96 and 97% for low-risk and 81 and 91% for high-risk patients. Risk classification was the only significant prognostic factor for relapse-free (p = 0.011) and disease-specific survival (p = 0.039). Among high-risk patients, the administration of 6 cycles was associated with a significantly lower relapse rate after censoring events, which occurred beyond 2 years (3 vs. 18%; p = 0.013), but this difference was diminished at 5 years (23 vs. 25%; p = 0.797). Conclusions: Six cycles of chemotherapy reduced the risk of relapse within 2 years, but the benefit from two additional cycles beyond this time is questionable. Copyright © 2012 S. Karger AG, Basel.

Environmental history often reveals the contribution of humans in the modification of natural environment, always in relation with the climatic factors. Archaeological settlements may be preserved through desiccation, however, they are commonly found in floodplain sediments. Archaeological evidences may provide with useful information about the processes and extent of environmental changes, but they may also be used as tools for the analysis of floodplain sedimentation, relative chronology of sedimentation events and for the geomorphological evaluation of the particular archaeological site. The characteristics of archaeological indicators and the deposits in which they occur, may indicate important aspects of their source, transportation way and age. Evidence of river migration may be found in alluvial plains, through careful observations. The study area is located in Kalavrita region in northern Peloponnese. The archaeological excavations carried out revealed the fortification wall of the ancient city of "Kleitor"which is dated between the 3rd and 2nd century BC (Hellenistic Period). It may also provide clues for land surface development, reworking of sedimentary deposits, paleoenvironmental and climatic conditions. Sediments indicating considerable climatic changes are alluvial deposits of considerable thickness, covering areas with human impact. All the aforementioned become a tool for dating the course changes of the rivers and consequently a geomorphological instability. The relationship between geomorphology and history is recognizable also in the settlement distribution. This close relationship between environment and man provides a tool to understanding the landscape evolution from a geomorphological and historical point of view.

An experimental campaign has been conducted in the frame of the European Commission funded network of excellence ECATS, at Athens International Airport (AIA), Greece, from 13 to 25 September 2007. In order to quantify the background air quality and study the influence of meteorological conditions and airport emissions to the broader region, the analysis was extended to the greater Messogia Plain of Attica, Greece. Mixing height was estimated taking into account measurements from remote sensing and surface based single point instrumentation. According to the analysis, the air quality over Messogia Plain is mainly controlled by the intensity and the direction of the background flow. Under low background wind conditions, the development of local flows (sea and land breeze cells) over the greater area preserves high concentrations of air pollutants which are mainly attributed to the airport emissions, the local activities and traffic. When the background flow is strong, the diurnal cycle of all concentrations was significantly reduced by more than 50%, due to the advection and the subsequent mixing of the lower atmosphere. In order to identify and quantify the various processes linked with meteorology and air quality, the Hilbert-Huang transform was selected to be applied on the air-quality time-series data. The calculated Hilbert spectra of the main pollutants showed that meteorology plays a prescriptive role on the evolution of air pollutants, determining the influence of the local scale characteristics at each station. © 2011 Elsevier Ltd.

Hyaluronan (HA) modulates key cancer cell functions through interaction with its CD44 and receptor for hyaluronic acid-mediated motility (RHAMM) receptors. HA was recently found to regulate the migration of fibrosarcoma cells in a manner specifically dependent on its size. Here, we investigated the effect of HA/RHAMM signaling on the ability of HT1080 fibrosarcoma cells to adhere onto fibronectin. Low molecular weight HA (LMWHA) significantly increased (p

In this work, we study theoretically the resonant coupling between longitudinal optical surface vibrations of Si-OH and/or Si-O-Si and electron and hole states in the silicon nanocrystals (Si NCs) within light emitting porous Si (PSi) thin films in the framework of the Fröhlich interaction. The results of this analysis are compared with experimental results, which show considerable enhancement and a redshift of the photoluminescence (PL) spectrum of a fresh as-grown PSi thin film after prolonged laser irradiation or after aging in air. These effects coincide with the formation of Si-OH and Si-O-Si bonds on the surface of PSi. The redshift of the PL spectrum is due to the pinning of the bandgap of the light emitting Si NCs, as both oxidation via laser irradiation in air and aging in air introduce energy states in the Si NC band gaps. According to the theoretical analysis, the PL enhancement is assigned to inhibition of nonradiative channels rather than to an enhancement of radiative channels in the Si NCs within the PSi film, due to a strong coupling of the surface Si-OH and/or Si-O-Si vibrational modes to the electronic sublevels in the Si NCs within the PSi layer. © 2011 American Institute of Physics.

During prostate carcinogenesis the cellular adhesion molecules, i.e.; integrins and cadherins mediate aberrant interactions between glandular epithelial cells and the extracellular matrix. Several integrin α subunits are downregulated, while β subunits are up-regulated. The expression of several cadherins and catenins has specific prognostic value. There is an association between the expression of the E-cadherin/catenin complex and high grade prostate cancer. Clinical trials evaluating the efficacy of integrin antagonists are ongoing with promising results. In this article we update the role of integrins and cadherins in prostate carcinogenesis and evaluate the therapeutic potential of their manipulation.

We have performed the Fourier decomposition analysis of 11-yr V-band light curves of a carefully selected sample of 100 RR Lyrae variables, detected in the central regions of the Small Magellanic Cloud (SMC), with the Optical Gravitational Lensing Experiment, phases II and III. The sample consisted of 84 fundamental mode pulsators (RRab stars) and 16 first-overtone pulsators (RRc stars). The Fourier decomposition parameters were used to derive metal abundances and distance moduli for these RR Lyrae variables. The average metal abundance of the RRab stars on the new scale of Carretta et al. is found to be <[Fe/H]C09>=-1.62 ± 0.41 dex (std, with a standard error of 0.05 dex). The distance modulus of the SMC was found to be <μ>= 18.90 ± 0.18 (std) from the RRab population in a distance scale where the distance modulus of the Large Magellanic Cloud (LMC) is μLMC= 18.52 ± 0.06 (std). The 1σ line-of-sight depth for the RRab stars was found to be σint= 4.13 ± 0.27 kpc, in good agreement with that estimated from red clump stars and eclipsing binaries. There is a clear indication that the metal-poorer and metal-richer objects in the sample may belong to different dynamical structures. The metal-rich stars have smaller scaleheight and could be part of a disc-like structure, while the more metal poor objects could be part of a much thicker structure, such as an inner halo or a bulge component.

Sarcomas of the fallopian tube are exceedingly rare malignancies. They have been considered the most lethal of all gynaecological malignancies with high metastatic potential, frequent recurrences and cancer-related deaths. The reported pathological types of the fallopian tube sarcomas are malignant mixed mullerian (mesodermal) tumours or carcinosarcomas, leiomyosarcomas, rhabdomyosarcomas, liposarcomas, and synovial sarcomas. The rarity of these sarcomas and their often aggressive clinical course has resulted in a relatively limited amount of literature. Thus a single hospital or specialist cannot gain sufficient experience with these tumours. This review article tries to elucidate this uncommon malignancy, in a systematic way, focusing on the different pathological types, epidemiology, risk factors, diagnosis, survival, and different therapeutic modalities (surgery, chemotherapy, and radiotherapy). Copyright © 2011 S. Karger AG, Basel.

Biomass burning and associated emissions of aerosols into the atmosphere play a vital role in atmospheric composition and climate change. During summer of 2007, Greece faced the worst natural disaster recorded in recent decades in terms of human losses, number of fire outbreaks and extent of the estimated burned area (more than 12% of the total forested areas in Greece). The present study aims at analyzing the impact of these fire events in western Peloponnese on atmospheric aerosol concentrations using satellite data. MODIS-derived Aerosol Optical Depth (AOD), effective radius, Ångström exponent, mass concentration, cloud-condensation nuclei (CCN) and OMI Aerosol Index (AI), single scattering albedo, absorption and extinction optical depths were analyzed. MODIS data showed smoke plumes traversing thousands of kilometers southwards influencing the central Mediterranean as well as the north African coastal regions. These thick smoke plumes dramatically affected AOD and aerosol-mass concentrations over the region and altered the microphysical aerosol properties, such as the effective radius and absorption coefficient. Model calculations suggested that the shortwave radiation at the ground was reduced by ∼50 Wm2, while that at the top of the atmosphere was reduced by ∼20 Wm2 resulting in atmospheric heating of ∼30 Wm2 over the areas affected by the smoke plumes. © 2010 Elsevier Ltd.