Publications by Year: 2014

2014
Liakos A, Gazeas K, Nanouris N. 105 minima timings of eclipsing binaries. [Internet]. 2014;6095:1. WebsiteAbstract
We present 105 times of minima of 33 eclipsing binaries.
Adamopoulos P, Kontos C, Rapti S, Christodoulou S, Papadopoulos I, Scorilas A. 1-Enhanced miR224 transcription predicts short-term relapse and poor overall survival in colorectal adenocarcinoma patients: Kontos, Christos. Clinical Chemistry and Laboratory Medicine. 2014;52.
Mavromoustakos T, Tsotinis A. 32nd cyprus-noordwijkerhout-camerino symposium: Trends in drug research 2014. ChemMedChem [Internet]. 2014;9(8):1903 - 1905. Website
Stute M, Gracia J, Vlahakis N, Tsinganos K, Mignone A, Massaglia S. 3D simulations of disc winds extending radially self-similar MHD models. [Internet]. 2014;439:3641 - 3648. WebsiteAbstract
Disc winds originating from the inner parts of accretion discs are considered as the basic component of magnetically collimated outflows. The only available analytical magnetohydrodynamic (MHD) solutions to describe disc-driven jets are those characterized by the symmetry of radial self-similarity. However, radially self-similar MHD jet models, in general, have three geometrical shortcomings: (i) a singularity at the jet axis, (ii) the necessary assumption of axisymmetry and (iii) the non-existence of an intrinsic radial scale, i.e. the jets formally extend to radial infinity. Hence, numerical simulations are necessary to extend the analytical solutions towards the axis, by solving the full three-dimensional equations of MHD and impose a termination radius at finite radial distance. We focus here on studying the effects of relaxing the (ii) assumption of axisymmetry, i.e. of performing full 3D numerical simulations of a disc wind crossing all MHD critical surfaces. We compare the results of these runs with previous axisymmetric 2.5D simulations. The structure of the flow in all simulations shows strong similarities. The 3D runs reach a steady state and stay close to axisymmetry for most of the physical quantities, except for the poloidal magnetic field and the toroidal velocity which slightly deviate from axisymmetry. The latter quantities show signs of instabilities, which, however, are confined to the region inside the fast magnetosonic separatrix surface. The forces present in the flow, both of collimating and accelerating nature, are in good agreement in both the 2.5D and the 3D runs. We conclude that the analytical solution behaves well also after relaxing the basic assumption of axisymmetry.
Stute M, Gracia J, Vlahakis N, Tsinganos K, Mignone A, Massaglia S. 3D simulations of disc winds extending radially self-similar MHD models. [Internet]. 2014;439:3641 - 3648. WebsiteAbstract
Disc winds originating from the inner parts of accretion discs are considered as the basic component of magnetically collimated outflows. The only available analytical magnetohydrodynamic (MHD) solutions to describe disc-driven jets are those characterized by the symmetry of radial self-similarity. However, radially self-similar MHD jet models, in general, have three geometrical shortcomings: (i) a singularity at the jet axis, (ii) the necessary assumption of axisymmetry and (iii) the non-existence of an intrinsic radial scale, i.e. the jets formally extend to radial infinity. Hence, numerical simulations are necessary to extend the analytical solutions towards the axis, by solving the full three-dimensional equations of MHD and impose a termination radius at finite radial distance. We focus here on studying the effects of relaxing the (ii) assumption of axisymmetry, i.e. of performing full 3D numerical simulations of a disc wind crossing all MHD critical surfaces. We compare the results of these runs with previous axisymmetric 2.5D simulations. The structure of the flow in all simulations shows strong similarities. The 3D runs reach a steady state and stay close to axisymmetry for most of the physical quantities, except for the poloidal magnetic field and the toroidal velocity which slightly deviate from axisymmetry. The latter quantities show signs of instabilities, which, however, are confined to the region inside the fast magnetosonic separatrix surface. The forces present in the flow, both of collimating and accelerating nature, are in good agreement in both the 2.5D and the 3D runs. We conclude that the analytical solution behaves well also after relaxing the basic assumption of axisymmetry.
Kontos C, Alexopoulou D, Christodoulou S, Papadopoulos I, Scorilas A. 3-Kallikrein-related peptidase 6 (KLK6) mRNA expression: an independent unfavorable prognosticator in colon cancer: Brattsand, Maria. Clinical Chemistry and Laboratory Medicine. 2014;52.
Kontos C, Rapti S, Christodoulou S, Papadopoulos I, Scorilas A. 4-miR-34a overexpression is a strong indicator of unfavorable survival outcome in colon cancer patients: Brattsand, Maria. Clinical Chemistry and Laboratory Medicine. 2014;52.
Rapti S, Kontos C, Christodoulou S, Papadopoulos I, Scorilas A. 5-miR-96: a novel molecular tissue biomarker predicting unfavorable outcome in colorectal cancer patients: Brattsand, Maria. Clinical Chemistry and Laboratory Medicine. 2014;52.
Calafat, F.M. Fcalafat@noc.ac.uk, Avgoustoglou E, Jordà G, Flocas H, Zodiatis G, Tsimplis MN, Kouroutzoglou J. The ability of a barotropic model to simulate sea level extremes of meteorological origin in the Mediterranean Sea, including those caused by explosive cyclones. Journal of Geophysical Research: Oceans [Internet]. 2014;119:7840-7853. Website
Hasman A, Mantas J, Zarubina T. An abridged history of medical informatics education in europe. Acta Inform Med. 2014;22(1):25-36.Abstract
This contribution presents the development of medical informatics education in Europe. It does not discuss all developments that took place. Rather it discerns several themes that indicate the progress in the field, starting from the initiation phase to the final quality control phase.
Stamopoulos D, Aristomenopoulou E, Manios E. Absolute supercurrent switch in ferromagnetic/superconducting/ferromagnetic trilayers operating at T > 4.2 K. APPLIED PHYSICS LETTERS. 2014;105(11).Abstract
Artificial (CoO-)Co/Nb/Co trilayers (TLs) are studied by means of magnetization, transport, and magnetic force microscopy measurements. By using these TLs as a model system, we provide definite means to distinguish the exchange-fields and stray-fields based magnetoresistance effects observed in relevant Ferromagnetic/Superconducting/Ferromagnetic (FM/SC/FM) structures. Accordingly, we isolate and exclusively focus on the stray-fields version, to report a complete supercurrent switch, Delta R/R-nor approximate to 100%, achieved at operating temperature T > 4.2 K. Detailed series of Co(60 nm)/Nb(d(Nb))/Co(60 nm) TLs are studied, in which all crucial parameters that relate to the outer Co layers and to the Nb interlayer were systematically varied to unveil the factors that motivate and/or promote the observed effect. We propose a compact model that fairly captures the underlying physics of the Co(60 nm)/Nb(d(Nb))/Co(60 nm) TLs studied here and can be generalized to assist understanding of the relevant processes in every kind of FM/SC/FM TLs. The presented results and accompanying model are both provocative for basic research and attractive for the design of cryogenic devices. (C) 2014 AIP Publishing LLC.
Kantaris M, Theodorou M, Galanis P, Kaitelidou D. Access and utilisation of health services by domestic helpers in Cyprus. The International Journal of Health Planning and Management. 2014;29:e383–e393.
Kantaris M, Theodorou M, Galanis P, Kaitelidou D. Access and utilisation of health services by domestic helpers in Cyprus. The International Journal of Health Planning and Management. 2014;29(4):e383-e393.
Bouchet O, Javaudin J-P, Kortebi A, El Abdellaouy H, Brzozowski M, Katsianis D, Mayer C, Guan H, Lebouc M, Fontaine F, et al. ACEMIND: The smart integrated home network. Proceedings - 2014 International Conference on Intelligent Environments, IE 2014. 2014:1-8.
Konstantinidou AE, Vrasidas C, Armenski G, Brcik L, Smeets A, Antovski L, Thomopoulou GE, Petrusevska G, Seiwerth S, van Krieken H. Acquiring diagnostic experience in placenta pathology through HIPON web course. Pathology. 2014;46:S124.
Vernadakis S, Moris D, Papadopoulos IN. Acute abdominal pain due to intussusception of the small intestine in a 17-year-old patient. Surgery (United States) [Internet]. 2014;156:1282-1283. Website
Vernadakis S, Moris D, Papadopoulos IN. Acute abdominal pain due to intussusception of the small intestine in a 17-year-old patient. Surgery. 2014;156:1282–1283.
Vernadakis S, Moris D, Papadopoulos IN. Acute abdominal pain due to intussusception of the small intestine in a 17-year-old patient. Surgery (United States). 2014;156:1282-1283.
de Silva D, Geromi M, Panesar SS, Muraro A, Werfel T, Hoffmann-Sommergruber K, Roberts G, Cardona V, Dubois AEJ, Halken S, et al. Acute and long-term management of food allergy: systematic review. Allergy. 2014;69(2):159-67.Abstract
BACKGROUND: Allergic reactions to food can have serious consequences. This systematic review summarizes evidence about the immediate management of reactions and longer-term approaches to minimize adverse impacts. METHODS: Seven bibliographic databases were searched from their inception to September 30, 2012, for systematic reviews, randomized controlled trials, quasi-randomized controlled trials, controlled clinical trials, controlled before-and-after and interrupted time series studies. Experts were consulted for additional studies. There was no language or geographic restrictions. Two reviewers critically appraised the studies using the appropriate tools. Data were not suitable for meta-analysis due to heterogeneity so were narratively synthesized. RESULTS: Eighty-four studies were included, but two-thirds were at high risk of potential bias. There was little evidence about acute management for non-life-threatening reactions. H1-antihistamines may be of benefit, but this evidence was in part derived from studies on those with cross-reactive birch pollen allergy. Regarding long-term management, avoiding the allergenic food or substituting an alternative was commonly recommended, but apart from for infants with cow's milk allergy, there was little high-quality research on this management approach. To reduce symptoms in children with cow's milk allergy, there was evidence to recommend alternatives such as extensively hydrolyzed formula. Supplements such as probiotics have not proved helpful, but allergen-specific immunotherapy may be disease modifying and therefore warrants further exploration. CONCLUSIONS: Food allergy can be debilitating and affects a significant number of people. However, the evidence base about acute and longer-term management is weak and needs to be strengthened as a matter of priority.
Kokras N, Pastromas N, Porto TH, Kafetzopoulos V, Mavridis T, Dalla C. Acute but not sustained aromatase inhibition displays antidepressant properties. Int J Neuropsychopharmacol. 2014;17(8):1307-13.Abstract
Aromatase inhibitors block the conversion of androgens to oestrogens and are used for the treatment of hormone-responsive breast cancer in menopause and recently also in premenopausal women. We investigate whether decreased oestrogen synthesis following aromatase inhibition leads to a depressive-like behavioural response in cycling female rats. Using the forced swim test (FST) we estimate the response of acute (three injections in 24 h) and sustained (7 d) letrozole and fluoxetine administration. Acute aromatase inhibition decreases immobility duration in the FST, indicating its antidepressant potential. Instead, sustained aromatase inhibition did not show such antidepressant potential. Testosterone elevation associates with the decreased depressive behaviour in the FST following acute letrozole treatment, but interestingly progesterone explains the increased swimming behaviour. Present findings may have potential implications for women treated with aromatase inhibitors, especially before menopause, as well as for the role of gonadal hormones in the expression of depressive symptoms and antidepressant response.
Kokras N, Pastromas N, Porto TH, Kafetzopoulos V, Mavridis T, Dalla C. Acute but not sustained aromatase inhibition displays antidepressant properties. Int J Neuropsychopharmacol. 2014;17:1307-13.Abstract
Aromatase inhibitors block the conversion of androgens to oestrogens and are used for the treatment of hormone-responsive breast cancer in menopause and recently also in premenopausal women. We investigate whether decreased oestrogen synthesis following aromatase inhibition leads to a depressive-like behavioural response in cycling female rats. Using the forced swim test (FST) we estimate the response of acute (three injections in 24 h) and sustained (7 d) letrozole and fluoxetine administration. Acute aromatase inhibition decreases immobility duration in the FST, indicating its antidepressant potential. Instead, sustained aromatase inhibition did not show such antidepressant potential. Testosterone elevation associates with the decreased depressive behaviour in the FST following acute letrozole treatment, but interestingly progesterone explains the increased swimming behaviour. Present findings may have potential implications for women treated with aromatase inhibitors, especially before menopause, as well as for the role of gonadal hormones in the expression of depressive symptoms and antidepressant response.
Papadaki C, Ntonidis L, Metzafou A, Zogaris S, Evelpidou N, Argyropoulou-Papa M, Dimitriou E. An adaptation of a habitat modeling approach to simulate and assess differences between existing habitat suitability criteria (HSC) focusing on brown trout for Greek rivers. In: 10th International Congress of the Hellenic Geographical Society. Thessaloniki, Greece; 2014.Abstract
The legislative framework in Greece regarding environmental flows is based mostly on hydromorphological criteria with little respect to the biotic elements of the rivers ecosystem. Nevertheless, the European Framework Directive (2000/60) outlines the importance of several groups of aquatic organisms that can be used as indices and provide valuable information about the water needs of the riverine ecosystem. Towards this direction, a habitat modelling approach was applied in this study to simulate and assess the alterations of the Weighted Usable Area (WUA) using existing habitat suitability criteria (HSC) for brown trout (adults and juvenile). Brown trout was selected because it is the most recreationally and economically important species in the study areas. Habitat models are designed for a wide variety of planning applications where habitat ecology is an important consideration in the decision process. Habitat Suitability Index curves used in this study describe the instream suitability of the habitat variables most closely related to stream hydraulics and channel structure (e.g., velocity, depth) for two life stages of the brown trout (adults and juvenile). The Brown Trout data are used provisionally to the complete absence of any local HSI development. For this preliminary application, depth and velocity values were converted into their corresponding habitat suitability index values using a GIS software. Among the HSC examined here, there were those that were cited by Boove (1978) and Raleigh et al (1986) and their development is based on literature sources or professional opinion. The demonstration applied here clearly identifies some of the utility in using HSC to potentially identify critical low-flow periods, where additional flow reductions may adversely affect water use, recreation, and aquatic species. The proposed method should be complemented with the ecological information of native fish species, and tested for transferability in other regions of Greece.
D'Oro S, Mertikopoulos P, Moustakas AL, Palazzo S. Adaptive transmit policies for cost-efficient power allocation in multi-carrier systems. In: Proc. 12th International Symposium on Modeling and Optimization in Mobile, Ad Hoc and Wireless Networks (WiOpt). ; 2014. pp. 1-7.
Triantaphyllou, M.V. /, Dimiza, M., Karatsolis, B. Adding proofs toSyracosphaera histrica-Calyptrolithophora pappiliferalife-cycle association. Journal of Nannoplankton Research [Internet]. 2014;34:57-59. Publisher's VersionAbstract
Two specimens of the coccolithophore Calyptrolithophora pappilifera associated with single exothecal and endothecal coccoliths of Syracosphaera histrica, collected from the North Aegean Sea (NE Mediterranean), have been verified by Scanning Electron Microscopy. The two specimens strengthen previous reported hints that Syracosphaera histrica and Calyptrolithophora pappilifera represent a life-cycle association, documenting accordingly the relationships between the different phases within the genus Syracosphaera.
Burnetas A, Kokaliaris C. Admission control policies in a finite capacity Geo/Geo/1 queue under partial state observations. Springer Optimization and Its Applications [Internet]. 2014;91:59-75. Website
Michala L, Creighton S. {Adolescent gynaecology}. Obstetrics, Gynaecology and Reproductive Medicine. 2014;24.Abstract
Adolescent gynaecology is increasingly recognized as an area in which specific knowledge and expertise is required to ensure that patients achieve the best outcome. Gynaecological problems in adolescents are common, and although serious pathology is rare, distress and discomfort can be significant. Adolescent girls are under greater pressure than ever before, particularly in terms of examination performance; they find menstrual dysfunction particularly difficult to manage. Careful and sympathetic assessment is crucial, and simple treatment remedies may be all that is required. However, complex and rare medical conditions can also occur and must not be missed. Some congenital disorders present for the first time in adolescence. Early detection and appropriate treatment will ensure the best possible outcomes in terms of sexual function and potential fertility. © 2014 Elsevier Ltd.
Petanidou D, Giannakopoulos G, Tzavara C, Dimitrakaki C, Kolaitis G, Tountas Y. Adolescents’ multiple, recurrent subjective health complaints: investigating associations with emotional/behavioural difficulties in a cross-sectional, school-based study. [Internet]. 2014;8(1):3. WebsiteAbstract
Adolescence has been documented as the peak age of onset for mental health perturbations, clinical disorders and unsubstantiated health complaints. The present study attempted to investigate associations between multiple, recurrent subjective health complaints (SHC) with emotional/behavioural difficulties, as measured by the Strengths and Difficulties Questionnaire scale (SDQ), among Greek adolescents.
Kostarelou, P. KPK-GMAIE. Aflatoxin B1 production by Aspergillus parasiticus and strains of Aspergillus section Nigri in currants of Greek origin. Food Control [Internet]. 2014;43:121-128. Website
Tavoulari, M. KPK-GMAIE. Aflatoxin B1 production by Aspergillus section Nigri strains isolated from greek dried vine fruits and competition with Aspergillus parasiticus. Fresenius Environmental Bulletin [Internet]. 2014;23:1744-1753. Website
Moschos MM, Nitoda E, Chatziralli IP, Demopoulos CA. Age-related macular degeneration: pathogenesis, genetic background, and the role of nutritional supplements. Journal of Chemistry. 2014;2014.
Moustris KP, Proias GT, Larissi IK, Nastos PT, Koukouletsos KV, Paliatsos AG. AIR QUALITY PROGNOSIS USING ARTIFICIAL NEURAL NETWORKS MODELING IN THE URBAN ENVIRONMENT OF VOLOS, CENTRAL GREECE. FRESENIUS ENVIRONMENTAL BULLETIN. 2014;23:2967–2975.
Gu Y, Scarmeas N, Short EE, Luchsinger JA, DeCarli C, Stern Y, Manly JJ, Schupf N, Mayeux R, Brickman AM. Alcohol intake and brain structure in a multiethnic elderly cohort. Clin Nutr. 2014;33(4):662-7.Abstract
BACKGROUND & AIMS: Evidence suggests that consuming light-to-moderate amounts of alcohol reduces the risk of dementia and is associated better cognitive function and less cardiovascular disease, relative to those consuming no or heavy alcohol. There are only minimal data on the association between alcohol and brain magnetic resonance imaging (MRI) markers. This study aimed to examine the association between alcohol and brain structure measured with MRI. METHODS: In this cross-sectional study, high-resolution structural MRI was collected on 589 multi-ethnic community residents of New York aged ≥65 with available alcohol intake assessments via a food frequency questionnaire. Total brain volume (TBV), white matter hyperintensity volume (WMHV), and presence of infarcts were derived from MRI scans with established methods. We examined the association of alcohol intake with these imaging markers using regression models adjusted for demographic, clinical, and vascular risk factors. RESULTS: Compared to non-drinking, light-to-moderate total alcohol (b = 0.007, p = 0.04) or wine (b = 0.008, p = 0.05) intake, but not beer or liquor intake, was associated with larger TBV. Further analysis showed a dose-response association between alcohol (p-trend = 0.03) or wine (p-trend = 0.006) and TBV. Overall, alcohol intake was not associated with WMHV or brain infarcts. CONCLUSIONS: Our study suggests that among older adults in the community, light-to-moderate alcohol intake, in particular wine, is associated with larger TBV. These findings suggest that light to moderate alcohol consumption is potentially beneficial for brain aging, but replication is needed.
Nieto A, Wahn U, Bufe A, Eigenmann P, Halken S, Hedlin G, Høst A, Hourihane J, Just J, Lack G, et al. Allergy and asthma prevention 2014. Pediatr Allergy Immunol. 2014.Abstract
Asthma and allergic diseases have become one of the epidemics of the 21st century in developed countries. Much of the success of other areas of Medicine, such as infectious diseases, lies on preventive measures. Thus, much effort is also being placed lately in the prevention of asthma and allergy. This manuscript reviews the current evidence, divided in four areas of activity. Interventions modifying environmental exposure to allergens have provided inconsistent results, with multifaceted interventions being more effective in the prevention of asthma. Regarding nutrition, the use of hydrolysed formulas in high risk infants reduces the incidence of atopic dermatitis, while there is for now not enough evidence to recommend other dietary modifications, prebiotics, probiotics, or other microbial products. Pharmacologic agents used until now for prevention have not proved useful, while there is hope that antiviral vaccines could be useful in the future. Allergen-specific immunotherapy is effective for the treatment of allergic patients with symptoms; the study of its value for primary and secondary prevention of asthma and allergy is in its very preliminary phases. The lack of success in the prevention of these disorders lies on their complexity, which involves many genetic, epigenetic and environmental interactions. There is a need to identify target populations, involved mechanisms and interactions, and the best interventions. These must be effective, feasible, implementable and affordable. This article is protected by copyright. All rights reserved.
TSOKOU MARIA. América Latina y el Viaje Americano de Concha Espina. In: Dueñas BS, Sotomayor MV Latinoamérica en los artículos de prensa de las escritoras españolas (1868-1936). Vol. 2014. FIRST. CÓRDOBA: DON FOLIO; 2014. pp. 126-133.
Smyrnis N, Protopapa F, Tsoukas E, Balogh A, Siettos CI, Evdokimidis I. Amplitude spectrum EEG signal evidence for the dissociation of motor and perceptual spatial working memory in the human brain. Experimental brain research. 2014;232:659–673.
Sanguinetti L, Moustakas AL, Debbah M. Analysis and Management of Interference in 5G Reverse TDD HetNets. In: First International Conference on 5G for Ubiquitous Connectivity. Levi, Finland; 2014. pp. 122-127.
Nastos PT, Matsangouras IT. Analysis of synoptic conditions for tornadic days over western Greece. Natural Hazards and Earth System Sciences [Internet]. 2014;14(9):2409 - 2421. WebsiteAbstract
Tornadoes have been reported in Greece during the last few decades and recent studies have given evidence that western Greece is an area vulnerable to tornadoes, waterspouts and funnel clouds In this study, the composite means and anomalies of synoptic conditions for tornadic events (tornadoes, waterspouts and funnel clouds) over western Greece are analyzed and discussed. The daily composite means of synoptic conditions were based on the National Centers for Environmental Prediction-National Center for Atmospheric Research (NCEP-NCAR) reanalysis data sets, for the period 12 August 1953 to 31 December 2012. The daily composite anomalies were calculated with respect to 30 years of climatological study (1981-2010) of the synoptic conditions. The analysis was carried out in terms of seasonal and monthly variability of composite means and anomalies of synoptic conditions for specific isobaric levels of 500, 700, 850, 925 hPa and the sea level pressure (SLP). In addition, an analysis and discussion about the dynamic lifted index from NCEP-NCAR reanalysis data sets is presented. The daily composite mean analysis of 500 hPa revealed a trough line across the northern Adriatic Sea and central Italy, associated with a SW upper-air stream over western Greece. The maximum composite anomalies were depicted at the isobaric level of 500 hPa during autumn, spring and summer, against winter when the anomaly appeared at 925 hPa isobaric level. In addition, 48% of tornado events during the autumn season occurred in pre-frontal weather conditions (cold fronts) and 27% developed after the passage of the cold front. Furthermore, the main difference in synoptic patterns between tornado and waterspout days along western Greece during the autumn season is the maximum daily composite anomaly over the Gulf of Taranto. © Author(s) 2014. CC Attribution 3.0 License.
Teixeira R, Monteiro R, Garcia J, Silva A, Graca M, Baptista R, others. Aortic arch mechanics in hypertensive patients versus controls, a two dimensional speckletracking study. Eur Heart J Cardiovasc Imaging. 2014;15:ii235–64.
Alexopoulos JD, Dilalos S, Poulos SE, Ghionis G, Mavroulis S. Application of geoelectrical techniques in the investigation of a coastal sand dune field. In: Near Surface Geoscience 2014 - 20th European Meeting of Environmental and Engineering Geophysics. ; 2014. Website
Alexopoulos JD, Dilalos S, Poulos S, Ghionis G, Mavroulis S. Application of geoelectrical techniques in the investigation of a coastal sand dune field. In: 20th European Meeting of Environmental and Engineering Geophysics. Vol. Tu_PA2_01. Athens, Greece; 2014. pp. 5. Publisher's VersionAbstract
A geophysical research was carried out to investigate the lithostarigraphic substratum characteristics of the dune field of the central Kyparissiakos Gulf (W. Peloponnese, Greece), which is characterised by the presence of four dune lines. For this purpose, the geophysical techniques of Electrical Resistivity Tomography (ERT) and Vertical Electrical Soundings (VES) were applied, along with detailed morphological mapping and the collection of geological and geomorphological information. The processing of the geophysical data that were collected from two ERT soundings, perpendicular to the general direction of the dune lines, and seven geoelectrical soundings revealed four geoelectrical layers with the two surficial resistive layers adumbrating the extent and thickness of the four sand dune ridges and the associated slags. The third layer, corresponding to the underlying geoelectrical formation of 50–75 Ohm.m, is interpreted as a layer of transgressive Holocene deposits saturated with fresh water, while the deepest geoelectrically identified layer seems to correspond to the “Neda” formation, which consists of marls, sandy marls and conglomerates. It is concluded that the combined application of the aforementioned techniques has the potential to provide valuable data for the investigation of complex coastal depositional environments.
Anastopoulou I, Eliopoulos C, Valakos ED, Manolis SK. Application of Purkait's triangle method on a skeletal population from southern Europe. Forensic Sci Int. 2014;245:203.e1-4.Abstract
The existence of sexual dimorphism in individual elements of the human skeleton allows sex determination and significantly enhances the identification of fragmentary skeletal material. Traditionally, the pelvis and the skull are used for an accurate sex determination. Sometimes they are not available and alternative methods have to be used. The aim of this work is to study the sexual dimorphism of the proximal portion of the posterior femur by analyzing the biometric data of the Purkait's triangle. The studied sample comprises 203 individuals (112 males and 91 females) from the Modern Human Skeletal Reference Collection (The Athens Collection) of the Department of Animal & Human Physiology (National & Kapodistrian University of Athens). The biometric data were analyzed by Discriminant Analysis and equations were generated for sex determination, which gave an overall correct classification of 78.3%. For the right and the left femur the percentages of correct classification were 77.8% and 75.9% respectively. These accuracy rates were compared to those of an Indian population and were found to be lower (86.5% for males and 86.3% for females). The study of sexual dimorphism (SD) in Greek, Indian, European-American and African-American populations gave interesting results. The AB diameter in the Greek sample shows the lowest degree of SD while the AC diameter shows the highest. In the other three population samples, the BC diameter shows the highest degree of SD. We assume that the femur anatomy of the Greeks is the major cause that the Purkait method does not give high rates of correct classification. It is therefore advisable that practitioners exercise caution when using this method on skeletal material from Greece, especially in forensic contexts.
Ntountaniotis D, Kellici T, Tzakos A, Kolokotroni P, Tselios T, Becker-Baldus J, Glaubitz C, Lin S, Makriyannis A, Mavromoustakos T. The application of solid-state NMR spectroscopy to study candesartan cilexetil (TCV-116) membrane interactions. Comparative study with the AT1R antagonist drug olmesartan. Biochimica et Biophysica Acta - Biomembranes [Internet]. 2014;1838(10):2439 - 2450. Website
Kassaras I, Kapetanidis V, Karakonstantis A, Kaviris G, Papadimitriou P, Voulgaris N, Makropoulos K, Popandopoulos G, Moshou A. The April-June 2007 Trichonis Lake earthquake swarm (W. Greece): New implications toward the causative fault zone. Journal of Geodynamics [Internet]. 2014;73:60 - 80. Website
Kassaras I, Kapetanidis V, Karakonstantis A, Kaviris G, Papadimitriou P, Voulgaris N, Makropoulos K, Popandopoulos G, Moshou A. The April–June 2007 Trichonis Lake earthquake swarm (W. Greece): New implications toward the causative fault zone. Journal of Geodynamics [Internet]. 2014;73:60 - 80. Publisher's VersionAbstract
On 10 April 2007, three moderate earthquakes with Mw=4.9–5.1 occurred in the vicinity of Trichonis Lake (W. Greece). A local network composed of 12 three-component digital seismographs was installed in the epicentral area and recorded more than 1600 events. The double-difference algorithm HYPODD, incorporating both catalog and waveform cross-correlation differential travel-time data, was applied for the successful relocation of 1490 earthquakes. The latter led to the distinction of a main NW-SE trending and NE-dipping zone, as well as of three neighboring faults; a conjugate NW-SE striking and SW-dipping marginal fault mapped along the northeastern flanks of the lake; a E-W trending and south-dipping low-angle normal fault, possibly related to the major Agrinio Fault Zone (AFZ), parallel to the northern bank of the lake; a NE-SW striking and NW-dipping normal fault, likely related to a segment of the active Evinos fault, located south of the lake. Calculation of the Coulomb stress induced by the combination of the 1975 Mw=6.0 event and the three largest events of 10 April 2007 on the inferred structures, reveals that most of the seismicity lies within the “stress-loaded” region, except for the westernmost activity, which probably belongs to the deep part of the AFZ. A total of 178 reliable focal mechanisms were determined by regional and local body-wave modeling (5 largest events) and P-wave first motion polarity data. The types of the obtained focal mechanisms are predominantly normal and strike-slip, however, numerous earthquakes were found to exhibit reverse faulting. Inversion of focal mechanism data showed that the prevailing principal horizontal component σ3 is quite homogeneous throughout the activated area with a roughly NW-SE trend, parallel to the strike of the Hellenides. On the contrary, the compressional field σ1 appears in two patterns: NE-SW trending onshore and NW-SE trending beneath the lake. This apparent rotation of σ1 by 90° reveals a complex system enclosed by the suggested NW-SE trending antithetic faults in depths between 7 and 9km. The calculated stress ratios beneath the lake imply that vertical forces are close to the overburden pressure. The overall inferred stress pattern is rather linked to topographic variations, locally imposing increase or decrease of the vertical forces. The presence of the water in the lake possibly plays an additional important role, penetrating through the bedrock, reducing the friction coefficient, while the pore pressure and, consequently, the effective stress increase. Thus, shearing along mature fractures is enhanced, likely yielding the observed diversity.
article_17_2014-trichonida.pdf
Kozielewicz P, Tzeli D, Tsoungas PG, Zloh M. Arene-fused 1,2-oxazole N-oxides and derivatives. The impact of the N-O dipole and substitution on their aromatic character and reactivity profile. Can it be a useful structure in synthesis? A theoretical insight. STRUCTURAL CHEMISTRY. 2014;25:1837-1846.
Protogerou AD, Papaioannou TG, Vlachopoulos C. Arterial stiffness mapping: A better navigation to ithaca?. Journal of the American College of Cardiology [Internet]. 2014;63(17):1748 - 1750. Website
Protogerou AD, Papaioannou TG, Vlachopoulos C. Arterial stiffness mapping: A better navigation to ithaca?. Journal of the American College of Cardiology [Internet]. 2014;63(17):1748 - 1750. Website
Nastos PT, Paliatsos AG, Koukouletsos KV, Larissi IK, Moustris KP. Artificial neural networks modeling for forecasting the maximum daily total precipitation at Athens, Greece. Atmospheric Research [Internet]. 2014;144:141 - 150. WebsiteAbstract
Extreme daily precipitation events are involved in significant environmental damages, even in life loss, because of causing adverse impacts, such as flash floods, in urban and sometimes in rural areas. Thus, long-term forecast of such events is of great importance for the preparation of local authorities in order to confront and mitigate the adverse consequences. The objective of this study is to estimate the possibility of forecasting the maximum daily precipitation for the next coming year. For this reason, appropriate prognostic models, such as Artificial Neural Networks (ANNs) were developed and applied. The data used for the analysis concern annual maximum daily precipitation totals, which have been recorded at the National Observatory of Athens (NOA), during the long term period 1891-2009. To evaluate the potential of daily extreme precipitation forecast by the applied ANNs, a different period for validation was considered than the one used for the ANNs training. Thus, the datasets of the period 1891-1980 were used as training datasets, while the datasets of the period 1981-2009 as validation datasets. Appropriate statistical indices, such as the coefficient of determination (R2), the index of agreement (IA), the Root Mean Square Error (RMSE) and the Mean Bias Error (MBE), were applied to test the reliability of the models. The findings of the analysis showed that, a quite satisfactory relationship (R2=0.482, IA=0.817, RMSE=16.4mm and MBE=+5.2mm) appears between the forecasted and the respective observed maximum daily precipitation totals one year ahead. The developed ANN seems to overestimate the maximum daily precipitation totals appeared in 1988 while underestimate the maximum in 1999, which could be attributed to the relatively low frequency of occurrence of these extreme events within GAA having impact on the optimum training of ANN. © 2013 Elsevier B.V.
Price D, Rasp G, Papadopoulos NG, Scadding G, Bousquet J. Assessing allergic rhinitis symptom control:results from a digital servey conducted during EAACI 2013. Allergy. 2014;69:96.
Nteli C, Galanis P, Koumpagioti D, Poursanidis G, Panagiotopoulou E, Matziou V. Assessing the effectiveness of an educational program on compliance with hand hygiene in a pediatric intensive care unit. Advances in Nursing. 2014;2014.
Nteli C, Galanis P, Koumpagioti D, Poursanidis G, Panagiotopoulou E, Matziou V. Assessing the effectiveness of an educational program on compliance with hand hygiene in a pediatric intensive care unit. Advances in Nursing. 2014;2014.
Knaup P, Ammenwerth E, Dujat C, Grant A, Hasman A, Hein A, Hochlehnert A, Kulikowski C, Mantas J, Maojo V, et al. Assessing the prognoses on Health care in the information society 2013--thirteen years after. J Med Syst. 2014;38(7):73.Abstract
Health care and information technology in health care is advancing at tremendous speed. We analysed whether the prognoses by Haux et al. - first presented in 2000 and published in 2002 - have been fulfilled in 2013 and which might be the reasons for match or mismatch. Twenty international experts in biomedical and health informatics met in May 2013 in a workshop to discuss match or mismatch of each of the 71 prognoses. After this meeting a web-based survey among workshop participants took place. Thirty-three prognoses were assessed matching; they reflect e.g. that there is good progress in storing patient data electronically in health care institutions. Twenty-three prognoses were assessed mismatching; they reflect e.g. that telemedicine and home monitoring as well as electronic exchange of patient data between institutions is not established as widespread as expected. Fifteen prognoses were assessed neither matching nor mismatching. ICT tools have considerably influenced health care in the last decade, but in many cases not as far as it was expected by Haux et al. in 2002. In most cases this is not a matter of the availability of technical solutions but of organizational and ethical issues. We need innovative and modern information system architectures which support multiple use of data for patient care as well as for research and reporting and which are able to integrate data from home monitoring into a patient centered health record. Since innovative technology is available the efficient and wide-spread use in health care has to be enabled by systematic information management.
Bleta A, Nastos PT, Matzarakis A. Assessment of bioclimatic conditions on Crete Island, Greece. Regional Environmental Change [Internet]. 2014;14(5):1967 - 1981. WebsiteAbstract
The objective of this study was to assess and analyze the human bioclimatic conditions of Crete Island, by applying two human thermal indices: physiological equivalent temperature (PET), derived from the Munich Energy-balance Model for Individuals human energy balance model, and Universal Thermal Climate Index (UTCI), based on the Fiala multi-node model of human thermoregulation. Human bioclimatic studies provide a framework for considering the effects of climatic conditions on human beings and highlighting the social/economic factors that mitigate or amplify the consequences of environmental changes. In order to estimate the thermal effect of the environment on the human body, it has been considered that the total effects of all thermal components, not only of individual parameters, should be taken into account. The climatic data (air temperature, relative humidity, cloudiness, wind speed) used in this study were acquired from the archives of the Hellenic National Meteorological Service, regarding ten meteorological stations in Crete Island. These data, covering the 30-year period 1975–2004, were used for the calculation of PET and UTCI in order to assess thermo-physiological stress levels. The findings of this analysis, such as bioclimatic diagrams, temporal and spatial distributions of PET and UTCI as well as trends and variability, will help stake holders to understand and interpret the island’s current bioclimate, in order to make any necessary adaptations and become more resilient to the foreseen climate change. © 2013, Springer-Verlag Berlin Heidelberg.
Dimou A, Vassilakis E, Antoniou V, Evelpidou N. An assessment of the coastal erosion at Marathon, East Attica (Greece). 10th International Congress of the Hellenic Geographical Society, 22-24 October. 2014:1579-1587.Abstract
The 7 kilometers long coastline of Marathon Gulf (East Attica, Greece), has been chosen for this study, in order to classify its coastal erosion, using the Coastal Vulnerability Index (CVI) through GIS technology, since several incidents of erosion have been identified during the past decades in the area. The CVI index is used for assessing the vulnerability of a coast to an anticipated future sea-level rise. It relates geological (coastal geomorphology, historical changes of coastline’s position, coastal slopes) and oceanographic (wave height, run up and tidal range) variables in a semi-quantitative manner. We combined different kinds of datasets extracted from high resolution panchromatic aerial photographs of several time periods (1960-2010) and traced the contemporary shoreline by high accuracy surveying with Real Time Kinematic (RTK) GPS equipment. The interpretation of all shorelines required geo-statistical analysis in a Geographical Information System, in order to estimate the rate of shoreline change for a period of 53 years. Retreating rates were calculated for each section reaching the value of 0.6 m/yr. According to the produced CVI values (10.61- 39.52), it is found that 46% of the coast has very high vulnerability, 20% high vulnerability, whilst 29% have low vulnerability. The area named “Plesti” at the southern part of the study area, a large segment at the coast of Nea Makri, the northern part of Agios Panteleimonas beach and the eastern estuary of the Inois river are those with the higher risk. These conclusions are in full agreement with the field observations.
Dimou Α, Vassilakis E, Antoniou Β, Evelpidou Ν. An assessment of the coastal erosion at Marathon, east Attica (Greece). 10th Congress of the Hellenic Geographical Society [Internet]. 2014:1579-1587. pdf
Monioudi IN, Karditsa A, Chatzipavlis A, Alexandrakis G, Andreadis OP, Velegrakis AF, Poulos SE, Ghionis G, Petrakis S, Sifnioti D, et al. {Assessment of vulnerability of the eastern Cretan beaches (Greece) to sea level rise}. Regional Environmental Change [Internet]. 2014. Website
Monioudi IN, Karditsa A, Chatzipavlis A, Alexandrakis G, Andreadis OP, Velegrakis AF, Poulos SE, Ghionis G, Petrakis S, Sifnioti D, et al. Assessment of vulnerability of the eastern Cretan beaches (Greece) to sea level rise. Regional Environmental Change [Internet]. 2014. Website
Janse JJ, Wong GWK, Potts J, Ogorodova LM, Fedorova OS, Mahesh PA, Sakellariou A, Papadopoulos NG, Knulst AG, Versteeg SA, et al. The association between foodborne and orofecal pathogens and allergic sensitization-Europrevall study. Pediatric Allergy and Immunology. 2014;25:250-256.
Pavlidou A, Kroupis C, Dimas K. Association of survivin splice variants with prognosis and treatment of breast cancer. World J.Clin.Oncol. [Internet]. 2014;5(5):883 - 894. WebsiteAbstract
The purpose of this study was the overview of current knowledge regarding the use of survivin and its isoforms in prognosis and treatment of breast cancer. An advanced search of Medline was performed using the following search strategy: "(survivin isoforms) OR (survivin transcript variants) AND (breast cancer) AND (neoplasm OR tumor OR cancer OR carcinoma)". Relevant studies were retrieved and processed thoroughly in order to analyze the related data. Besides wild-type survivin full-length transcript, another six splice variants have been identified. Overexpression of survivin and its isoforms leads to shorter overall and disease-free survival; the transcript variants are correlated with apoptosis and could assist prognosis prediction. It has been proved through numerous studies that inhibiting survivin isoforms might become a promising target of drug therapy of carcinomas. Use of small molecule YM155 could offer new therapy for triple negative breast cancer patients, while, chemotherapy with 5-fluorouracil + epirubicin + cyclophosphamide and Tax-Epi could be guided by survivin splice variants measurements. Survivin transcript variants could become prognostic biomarkers and could provide information about clinical management of patients suffering from breast cancer
Kioulos KT, Bergiannaki JD, Vassiliadou M, Soldatos CR. Association of the Religiosity Dimensions of Forgivenss to Psychopathology in Greek Students. In: World Psychiatric Association, Pluralism in Psychiatry. I. Diverse Approaches and Converging Goals. Italy: Medimond International Proceedings; 2014. pp. 121-126. association_of_the_religiosity_dimensions_of_forgivenss_to_psychopathology_in_greek_students.pdf
Pentheroudakis G, Kotoula V, Kouvatseas G, Charalambous E, Dionysopoulos D, Zagouri F, Koutras A, Papazisis K, Pectasides D, Samantas E, et al. Association of VEGF-A splice variant mRNA expression with outcome in bevacizumab-treated patients with metastatic breast cancer. Clinical Breast Cancer [Internet]. 2014;14(5):330 - 338. WebsiteAbstract
We studied tissue mRNA levels of VEGF-Axxxa angiogenic versus VEGF-Axxxb anti-angiogenic isoforms by means of specially designed PCR assays in two parallel cohorts of metastatic breast cancer patients, one treated with taxane (Cohort A) and one treated with taxaneDbevacizumab (Cohort B). Tissue mRNA expression of angiogenic VEGF-Axxxa isoforms was retrospectively associated with adverse prognosis in the absence of bevacizumab and with favorable outcome when bevacizumab was administered. Background: The prognostic utility of vascular endothelial growth factor A (VEGF-A) splice variants in patients with advanced breast cancer treated with bevacizumab has not been studied. Patients and Methods: A total of 111 patients with metastatic breast cancer treated with weekly docetaxel or ixabepilone without bevacizumab (cohort A) and 100 treated with weekly paclitaxel and bevacizumab (cohort B) were studied. Formalin-fixed tumors were macrodissected for reverse transcription quantitative polymerase chain reaction relative quantification of VEGF-A165, -189, and -206 isoforms spliced at exon 8 proximal splice site (VEGF-Axxxa) and at exon 8 distal splice site (VEGF-Axxxb). Results: For high VEGF-Axxxa, the hazard ratios (HRs) for progression were 1.08 (P = .71) in non-bevacizumab-treated patients (cohort A) and 0.66 (P = .22) in bevacizumab-treated patients (cohort B), and the HRs for death were 1.45 (P = .13) and 0.50 (P = .049), respectively. The interaction of VEGF-Axxxa with bevacizumab administration was significant (P = .011) for overall survival (OS). High tissue VEGF-Axxxb was not prognostic in cohort A but was predictive for bevacizumab benefit in cohort B (HR for progression, 0.57 [P = .04]; HR for death, 0.51 [P = .02]). Exploratory analyses done only in cohort B suggested that abundance of VEGFR1 messenger RNA (mRNA) in peripheral blood and low VEGFR2 mRNA in tissue correlated with poor outcome. In multivariate analysis, high tissue mRNA of angiogenic VEGFAxxxa in the presence of bevacizumab therapy predicted for favorable progression-free survival (HR for progression, 0.39; P = .0227) and OS (HR for death, 0.32; P = .0140). Conclusion: Tissue mRNA expression of angiogenic VEGFAxxxa isoforms was retrospectively associated with adverse prognosis in the absence of bevacizumab and with favorable outcome when bevacizumab was administered in patients with advanced breast cancer. © 2014 Elsevier Inc.
Matsangouras IT, Nastos PT, Pytharoulis I, Migglieta MM. Atmospheric conditions analysis of waterspout events based on thermodynamic environment and sea surface temperature distribution over south Aegean Sea. COMECAP2014–ebook of contributions, edited by: Kanakidou, M., Mihalopoulos, N., and Nastos, P., Proceedings 12th International Conference of Meteorology, Climatology and Physics of the Atmosphere, Greece, Crete University Press ; 2014.
Isaksen ISA, Berntsen TK, Dalsøren SB, Eleftheratos K, Orsolini Y, Rognerud B, Stordal F., Søvde OA, Zerefos CS, Holmes CD. Atmospheric ozone and methane in a changing climate. Atmosphere [Internet]. 2014;5:518-535. Publisher's Version a23_atmosphere_2014.pdf
Stamopoulos D, Aristomenopoulou E, Sandim MJR, Sandim HRZ, Pissas M. An atomic force microscopy study of Eurofer-97 steel Niarchos D, Hadjipanayis G, Kalogirou O. JEMS 2013 - JOINT EUROPEAN MAGNETIC SYMPOSIA. 2014;75(7th Joint European Magnetic Symposia (JEMS).Abstract
In recent years the microstructure, mechanical and magnetic properties of Eurofer-97 steel are studied intensively due to its application in nuclear fusion power plants. Its microstructure is usually accessed by means of electron microscopy. Here we present an alternative approach utilizing Atomic Force Microscopy (AFM) to study as-received Eurofer-97 steel. We recorded both the Height Signal (HS) and Phase Signal (PS) that provided information on the morphologic and inelastic topography, respectively. With the HS we detected spherical particles (SPs) of size 50-2000 nm. Interestingly, micrometer SPs (0.1-2.0 mu m) are randomly distributed, while nanometer SPs (50-100 nm) are sometimes arranged in correlation to grain boundaries. The PS clearly revealed that the micrometer SPs exhibit inelastic properties. Though we cannot identify the elemental composition of the SPs with AFM, based on relevant electron microscopy data we ascribe the nanometer ones to the TaC, TiN and VN and the coarse micrometer ones to M23C6 (M=Cr, Fe). The latter class of SPs can probably be active sites that influence the mechanical properties of Eurofer-97 steel upon annealing as observed in relevant electron microscopy based studies.
Madesis I, Dimitriou A, Lagoyannis A, Axiotis M, Mertzimekis TJ, Andrianis M, Benis EP, Harissopulos S, Sulik B, Valastyan I. Atomic Physics with Accelerators: Projectile Electron Spectroscopy. [Internet]. 2014. Website
Vasilopoulou M, Georgiadou DG, Soultati A, Boukos N, Gardelis S, Palilis LC, Fakis M, Skoulatakis G, Kennou S, Botzakaki M, et al. Atomic-Layer-Deposited Aluminum and Zirconium Oxides for Surface Passivation of TiO2 in High-Efficiency Organic Photovoltaics. Advanced Energy Materials [Internet]. 2014;4. WebsiteAbstract
The reduction in electronic recombination losses by the passivation of surfaces is a key factor enabling high-efficiency solar cells. Here a strategy to passivate surface trap states of TiO2 films used as cathode interlayers in organic photovoltaics (OPVs) through applying alumina (Al2O3) or zirconia (ZrO2) insulating nanolayers by thermal atomic layer deposition (ALD) is investigated. The results suggest that the surface traps in TiO2 are oxygen vacancies, which cause undesirable recombination and high electron extraction barrier, reducing the open-circuit voltage and the short-circuit current of the complete OPV device. It is found that the ALD metal oxides enable excellent passivation of the TiO2 surface followed by a downward shift of the conduction band minimum. OPV devices based on different photoactive layers and using the passivated TiO2 electron extraction layers exhibit a significant enhancement of more than 30% in their power conversion efficiencies compared to their reference devices without the insulating metal oxide nanolayers. This is a result of significant suppression of charge recombination and enhanced electron extraction rates at the TiO2/ALD metal oxide/organic interface. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Kastritis E, Terpos E, Dimopoulos MA. Author's reply. Expert opinion on pharmacotherapy [Internet]. 2014;15(2):300. Website
Christodouleas DC, Giokas DL, Garyfali V, Papadopoulos K, Calokerinos AC. An automatic FIA-CL method for the determination of antioxidant activity of edible oils based on peroxyoxalate chemiluminescence. Microchemical Journal [Internet]. 2014;118:73-79. Website
Syriopoulos T, Gavalas D. Bank credit risk management and migration analysis; conditioning transition matrices on the stage of the business cycle. International Advances in Economic Research. 2014;20(2):151-166.
Syriopoulos T, Gavalas D. Bank credit risk management and rating migration analysis on the business cycle. International Journal of Financial Studies. 2014;2(1):122-143.
Syriopoulos T, Gavalas D. Basel III and its effects on banking performance: investigating lending rates and loan quantity. Journal of Finance and Bank Management. 2014;2(3):17-52.
Schwartz SH, Caprara GV, Vecchione M, Bain P, Bianchi G, Caprara MG, Cieciuch J, Lönnqvist J-E, Kirmanoglu H, Baslevent C, et al. Basic personal values underlie and give coherence to political values: A cross-national study in 15 countries. Political Behavior. 2014;36(4):889-930.
Katsanos K, Spiliopoulos S, Karunanithy N, Krokidis M, Sabharwal T, Taylor P. Bayesian network meta-analysis of nitinol stents, covered stents, drug-eluting stents, and drug-coated balloons in the femoropopliteal artery. Journal of Vascular Surgery [Internet]. 2014;59:1123-1133.e8. Website
Katsanos K, Spiliopoulos S, Karunanithy N, Krokidis M, Sabharwal T, Taylor P. Bayesian network meta-analysis of nitinol stents, covered stents, drug-eluting stents, and drug-coated balloons in the femoropopliteal artery. Journal of Vascular Surgery [Internet]. 2014;59(4):1123 - 1133.e8. Website
Achilleos V, Frantzeskakis DJ, Kevrekidis PG. Beating dark-dark solitons and Zitterbewegung in spin-orbit-coupled Bose-Einstein condensates. Physical Review A - Atomic, Molecular, and Optical Physics [Internet]. 2014;89. Website
Nistazakis HE, Stassinakis AN, Sheikh Muhammad S, Tombras GS. BER estimation for multi-hop RoFSO QAM or PSK OFDM communication systems over gamma gamma or exponentially modeled turbulence channels. Optics and Laser Technology [Internet]. 2014;64:106-112. Website
Nistazakis HE, Stassinakis AN, Sheikh Muhammad S, Tombras GS. BER estimation for multi-hop RoFSO QAM or PSK OFDM communication systems over gamma gamma or exponentially modeled turbulence channels. Optics and Laser Technology [Internet]. 2014;64:106-112. Website
Kozielewicz P, Tsoungas PG, Tzeli D, Petsalakis ID, Zloh M. beta-Nitroso-o-quinone methides: potent intermediates in organic chemistry and biology. The impact of the NO group on their structure and reactivity profile: a theoretical insight. STRUCTURAL CHEMISTRY. 2014;25:1711-1723.
Agaoglou M, Rothos VM, Frantzeskakis DJ, Veldes GP, Susanto H. Bifurcation results for traveling waves in nonlinear magnetic metamaterials. International Journal of Bifurcation and Chaos [Internet]. 2014;24. Website
Mariolis-Sapsakos T, Kalles V, Papapanagiotou I, Bonatsos V, Orfanos N, Kaklamanos IG, Manolis E. Bilateral aberrant origin of the inferior thyroid artery from the common carotid artery. Surg Radiol Anat. 2014;36(3):295-7.Abstract
The thyroid gland is mainly supplied by the superior and inferior thyroid arteries, with the latter being its principal arterial supply in adults. The inferior thyroid artery usually arises from the thyrocervical trunk, and less frequently from the subclavian artery. Rarely, it may originate from the vertebral artery or the common carotid artery. In the present report, we describe a unique case of a 56-year-old patient, undergoing total thyroidectomy and level VI lymph node dissection for papillary thyroid carcinoma, with aberrant origin of both inferior thyroid arteries from the common carotid arteries.
Mellema JJ, Doornberg JN, Guitton TG, Ring D. Biomechanical studies: science (f)or common sense?. Injury. 2014;45(12):2035-9.Abstract
INTRODUCTION: It is our impression that many biomechanical studies invest substantial resources studying the obvious: that more and larger metal is stronger. The purpose of this study is to evaluate if a subset of biomechanical studies comparing fixation constructs just document common sense. METHODS: Using a web-based survey, 274 orthopaedic surgeons and 81 medical students predicted the results of 11 biomechanical studies comparing fracture fixation constructs (selected based on the authors' sense that the answer was obvious prior to performing the study). Sensitivity, specificity, and accuracy were calculated according to standard formulas. The agreement among the observers was calculated by using a multirater kappa, described by Siegel and Castellan. RESULTS: The accuracy of predicting outcomes was 80% or greater for 10 of 11 studies. Accuracy was not influenced by level of experience (i.e., time in practice and medical students vs. surgeons). There were substantial differences in accuracy between observers from different regions. The overall categorical rating of inter-observer reliability according to Landis and Koch was moderate (κ=0.55; standard error (SE)=0.01). CONCLUSION: The results of a subset of biomechanical studies comparing fracture fixation constructs can be predicted prior to doing the study. As these studies are time and resource intensive, one criterion for proceeding with a biomechanical study should be that the answer is not simply a matter of common sense.
Kassimis G, Spiliopoulos S, Katsanos K, Tsetis D, Krokidis ME. Bioresorbable scaffolds in peripheral arterial disease. Expert Review of Cardiovascular Therapy [Internet]. 2014;12:443-450. Website
Kassimis G, Spiliopoulos S, Katsanos K, Tsetis D, Krokidis ME. Bioresorbable scaffolds in peripheral arterial disease. Expert Review of Cardiovascular Therapy [Internet]. 2014;12(4):443 - 450. Website
Book review of Peters M. A., Besley, T. &amp; Araya, D. (eds). <em>The New Development</em> <em>Paradigm: Education, Knowledge Economy and Digital Futures</em>. New York: Peter Lang.
Mitsikopoulou B. Book review of Peters M. A., Besley, T. & Araya, D. (eds). The New Development Paradigm: Education, Knowledge Economy and Digital Futures. New York: Peter Lang. Teachers College Record [Internet]. 2014;116(5). Publisher's Version the_new_development_paradigm_book_review.pdf
Tsitouras C, Katsikis VN. Bounds for variable degree rational L∞ approximations to the matrix cosine. Computer Physics Communications. 2014;185:2834–2840.
Chatziralli IP, Jaulim A, Peponis VG, Mitropoulos PG, Moschos MM. Branch retinal vein occlusion: treatment modalities: an update of the literature. In: Seminars in Ophthalmology. Vol. 29. Taylor & Francis; 2014. pp. 85–107.
Almpanis E, Papanikolaou N, Stefanou N. Breakdown of the linear acousto-optic interaction regime in phoxonic cavities. Optics Express. 2014;22(26):31595-31607.Abstract
The limits of validity of the linear photoelastic model are investigated in a one-dimensional dual photonic-phononic cavity, formed by alternating layers of a chalcogenide glass and a polymer homogeneous and isotropic material, which supports both optical and acoustic resonant modes localized in the same region. It is shown that the linear-response regime breaks down when either the acoustic excitation increases or the first-order acousto-optic interaction coupling element vanishes by symmetry, giving rise to the manifestation of multiphonon absorption and emission processes by a photon. Our results provide a consistent interpretation of different aspects of the underlying physics relating to nonlinear acousto-optic interactions that can occur in such cavities.
Karagianni M, Kaitelidou D, Kalokairinou A, Mantas J. Breast cancer in social media: a literature review. Stud Health Technol Inform. 2014;202:321.
Palapanidi K, Agustín Llach MP. Can lexical errors inform about word class acquisition?. Revista de Lingüística y Lenguas Aplicadas [Internet]. 2014;9:67-78. Publisher's VersionAbstract
This research examines the order of acquisition of words of four different classes: verbs, nouns, adjectives, and adverbs in three different levels of proficiency in the FL. We apply the procedure of Error Analysis to a corpus of written compositions and analyze the interlingual and intralingual lexical errors (formal and semantic) of the Greek students of Spanish as a Foreign Language (SFL). Our results have shown us that there is relationship between the type of word and the production of lexical errors and that the lexical errors present different trend in the different word classes. Additionally, our results lead us to the conclusion that the word class as a stronger predictor of lexical error type than proficiency level.
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Daikos GL, Tsaousi S, Tzouvelekis LS, Anyfantis I, Psichogiou M, Argyropoulou A, Stefanou I, Sypsa V, Miriagou V, Nepka M, et al. Carbapenemase-producing Klebsiella pneumoniae bloodstream infections: lowering mortality by antibiotic combination schemes and the role of carbapenems. Antimicrob Agents ChemotherAntimicrobial agents and chemotherapyAntimicrobial agents and chemotherapy. 2014;58:2322-8.Abstract
Carbapenemase-producing Klebsiella pneumoniae strains (CP-Kps) are currently among the most important nosocomial pathogens. An observational study was conducted during 2009 to 2010 in two hospitals located in a high-prevalence area (Athens, Greece). The aims were (i) to evaluate the clinical outcome of patients with CP-Kp bloodstream infections (BSIs), (ii) to identify predictors of mortality, and (iii) to evaluate the various antibiotic schemes employed. A total of 205 patients with CP-Kp BSIs were identified: 163 (79.5%) were infected with KPC or KPC and VIM, and 42 were infected with VIM producers. For definitive treatment, 103 patients received combination therapy (two or more active drugs), 72 received monotherapy (one active drug), and 12 received therapy with no active drug. The remaining 18 patients died within 48 h after the onset of bacteremia. The all-cause 28-day mortality was 40%. A significantly higher mortality rate was observed in patients treated with monotherapy than in those treated with combination therapy (44.4% versus 27.2%; P=0.018). The lowest mortality rate (19.3%) was observed in patients treated with carbapenem-containing combinations. In the Cox proportion hazards model, ultimately fatal disease (hazards ratio [HR], 3.25; 95% confidence interval [CI], 1.51 to 7.03; P=0.003), the presence of rapidly fatal underlying diseases (HR, 4.20; 95% CI, 2.19 to 8.08; P<0.001), and septic shock (HR, 2.15; 95% CI, 1.16 to 3.96; P=0.015) were independent predictors of death. Combination therapy was strongly associated with survival (HR of death for monotherapy versus combination, 2.08; 95% CI, 1.23 to 3.51; P=0.006), mostly due to the effectiveness of the carbapenem-containing regimens.
Gastounioti A, Kolias V, Golemati S, Tsiaparas NN, Matsakou A, Stoitsis JS, Kadoglou NP, Gkekas C, Kakisis JD, Liapis CD, et al. CAROTID - a web-based platform for optimal personalized management of atherosclerotic patients. Comput Methods Programs Biomed [Internet]. 2014;114(2):183-193. Publisher's VersionAbstract
Carotid atherosclerosis is the main cause of fatal cerebral ischemic events, thereby posing a major burden for public health and state economies. We propose a web-based platform named CAROTID to address the need for optimal management of patients with carotid atherosclerosis in a twofold sense: (a) objective selection of patients who need carotid-revascularization (i.e., high-risk patients), using a multifaceted description of the disease consisting of ultrasound imaging, biochemical and clinical markers, and (b) effective storage and retrieval of patient data to facilitate frequent follow-ups and direct comparisons with related cases. These two services are achieved by two interconnected modules, namely the computer-aided diagnosis (CAD) tool and the intelligent archival system, in a unified, remotely accessible system. We present the design of the platform and we describe three main usage scenarios to demonstrate the CAROTID utilization in clinical practice. Additionally, the platform was evaluated in a real clinical environment in terms of CAD performance, end-user satisfaction and time spent on different functionalities. CAROTID classification of high- and low-risk cases was 87%; the corresponding stenosis-degree-based classification would have been 61%. Questionnaire-based user satisfaction showed encouraging results in terms of ease-of-use, clinical usefulness and patient data protection. Times for different CAROTID functionalities were generally short; as an example, the time spent for generating the diagnostic decision was 5min in case of 4-s ultrasound video. Large datasets and future evaluation sessions in multiple medical institutions are still necessary to reveal with confidence the full potential of the platform.
Tselekounis M, Varoutas D, Martakos D. A CDS approach to induce facilities-based competition over NGA networks. Telecommunications Policy. 2014;38:311–331.
Dalamaga M, Sotiropoulos GP, Vrioni G, Tsakris A. Cedecea: An "unknown" pathogen in the family of Enterobacteriaceae - Its clinical importance, detection and identification methods. Acta Microbiologica Hellenica [Internet]. 2014;59(1):17 - 28. Website
Mlynek G, Lehner A, Neuhold J, Leeb S, Kostan J, Charnagalov A, Stolt-Bergner P, Djinovic-Carugo K, Pinotsis N. The Center for Optimized Structural Studies (COSS) platform for automation in cloning, expression, and purification of single proteins and protein-protein complexes. Amino Acids. 2014;46:1565-82.Abstract
Expression in Escherichia coli represents the simplest and most cost effective means for the production of recombinant proteins. This is a routine task in structural biology and biochemistry where milligrams of the target protein are required in high purity and monodispersity. To achieve these criteria, the user often needs to screen several constructs in different expression and purification conditions in parallel. We describe a pipeline, implemented in the Center for Optimized Structural Studies, that enables the systematic screening of expression and purification conditions for recombinant proteins and relies on a series of logical decisions. We first use bioinformatics tools to design a series of protein fragments, which we clone in parallel, and subsequently screen in small scale for optimal expression and purification conditions. Based on a scoring system that assesses soluble expression, we then select the top ranking targets for large-scale purification. In the establishment of our pipeline, emphasis was put on streamlining the processes such that it can be easily but not necessarily automatized. In a typical run of about 2 weeks, we are able to prepare and perform small-scale expression screens for 20-100 different constructs followed by large-scale purification of at least 4-6 proteins. The major advantage of our approach is its flexibility, which allows for easy adoption, either partially or entirely, by any average hypothesis driven laboratory in a manual or robot-assisted manner.
Apostolidis N, Bogdanis GC, Kostopoulos N, Souglis A, Papadopoulos C. Changes in the lipid profile of elite basketball and soccer players after a match. Research in Sports Medicine [Internet]. 2014;22(1):100 - 110. WebsiteAbstract
The lipid profile of elite basketball and soccer athletes was evaluated and compared with that of inactive individuals. Total cholesterol (T-C), low and high density lipoprotein cholesterol (LDL-C and HDL-C), and triglyceride (TG) concentration were measured in the morning and after a soccer or a basketball match. All parameters of lipid profile measured at a fasted and resting state, except HDL-C, were lower in the athletes compared with the controls (p < 0.01). The soccer match resulted in a greater decrease in TG (78.3 ± 6.7 to 70.7 ± 6.3, p < 0.01), T-C (179.3 ± 10.7 to 171.6 ± 9.6, p < 0.01), LDL-C (110.9 ± 8.9 to 103.5 ± 7.5, p < 0.01) compared with the basketball match that resulted only in a decrease in LDL-C (126.8 ± 9.5 to 117.3 ± 9.1, p < 0.01) and an increase in HDL-C that was similar to that observed after the soccer match (9-12%). These findings support the beneficial effects of basketball and soccer on cardiovascular health. © 2013 © Taylor & Francis Group, LLC.
Apostolidis N a, Bogdanis GC a, Kostopoulos N a, Souglis A a, Papadopoulos C b. Changes in the lipid profile of elite basketball and soccer players after a match. Research in Sports Medicine [Internet]. 2014;22:100-110. WebsiteAbstract
The lipid profile of elite basketball and soccer athletes was evaluated and compared with that of inactive individuals. Total cholesterol (T-C), low and high density lipoprotein cholesterol (LDL-C and HDL-C), and triglyceride (TG) concentration were measured in the morning and after a soccer or a basketball match. All parameters of lipid profile measured at a fasted and resting state, except HDL-C, were lower in the athletes compared with the controls (p < 0.01). The soccer match resulted in a greater decrease in TG (78.3 ± 6.7 to 70.7 ± 6.3, p < 0.01), T-C (179.3 ± 10.7 to 171.6 ± 9.6, p < 0.01), LDL-C (110.9 ± 8.9 to 103.5 ± 7.5, p < 0.01) compared with the basketball match that resulted only in a decrease in LDL-C (126.8 ± 9.5 to 117.3 ± 9.1, p < 0.01) and an increase in HDL-C that was similar to that observed after the soccer match (9-12%). These findings support the beneficial effects of basketball and soccer on cardiovascular health. © 2013 © Taylor & Francis Group, LLC.
Apostolidis, N.a BKSPGC a N. Changes in the lipid profile of elite basketball and soccer players after a match. Research in Sports Medicine [Internet]. 2014;22:100-110. WebsiteAbstract
The lipid profile of elite basketball and soccer athletes was evaluated and compared with that of inactive individuals. Total cholesterol (T-C), low and high density lipoprotein cholesterol (LDL-C and HDL-C), and triglyceride (TG) concentration were measured in the morning and after a soccer or a basketball match. All parameters of lipid profile measured at a fasted and resting state, except HDL-C, were lower in the athletes compared with the controls (p < 0.01). The soccer match resulted in a greater decrease in TG (78.3 ± 6.7 to 70.7 ± 6.3, p < 0.01), T-C (179.3 ± 10.7 to 171.6 ± 9.6, p < 0.01), LDL-C (110.9 ± 8.9 to 103.5 ± 7.5, p < 0.01) compared with the basketball match that resulted only in a decrease in LDL-C (126.8 ± 9.5 to 117.3 ± 9.1, p < 0.01) and an increase in HDL-C that was similar to that observed after the soccer match (9-12%). These findings support the beneficial effects of basketball and soccer on cardiovascular health. © 2013 © Taylor & Francis Group, LLC.
Vavouranakis G. The changing significance of nature within Minoan society. In: Touchais G, Laffineur R, Andreou S, Rougement F, Prokopiou H, Fouache E Physis: Natural environment and human interaction in the Prehistoric Aegean. 14th international Aegean conference, Institut National d’Histoire de l’Art (INHA), University Paris 1 Panthéon-Sorbonne, 11-14 December 2012 (Aegaeum 37). Louvain and Liège: Peeters; 2014. pp. 559-560.
Paraskevopoulou V, Dassenakis M, Botsou F, Teou X, Sakkelari A, Diamantis V, Poulos S, Lazogiannis K, Matiatos J, Sifnioti D, et al. Chemical quality of groundwaters in the deltaic plain of Pinios river: Preliminary results after a year of monitoring. In: Liakopoulos, Kungolos, Christodoulatos, Koutsopsyros 12th International Conference on Protection and Restoration of the Environment . Athens; 2014. pp. 154-161.Abstract
In this contribution we present some preliminary findings on the chemical quality of groundwaters of the deltaic plain of R. Pinios (Thessaly), as part of the implementation of the project THALISDAPHNE. Samples were obtained from 13 groundwater drillings on a seasonal basis during the hydrological year 2012 - 2013 and analyzed for major ions, nutrients, dissolved organic carbon and trace metals. Temperature, pH, conductivity and salinity were measured in situ. In order to evaluate the groundwater quality, we compare the data obtained against the Hellenic legislation threshold values and FAO guidelines for irrigation waters. Conductivity ranged from 230 to 9180 μS/cm. Exceedance of the 700 μS/cm threshold (Type I water FAO) in 71% of the samples suggests slight to moderate restrictions in irrigation. In two drillings (No 10, 13) maximum permissible limits of conductivity, sodium and chloride concentrations were exceeded particularly in summer and autumn. Some exceedances of guidelines were also identified for nitrates and ammonium. Concentrations of dissolved trace metals, were generally below the limits, with the exception of Zn, however some concern has been raised in terms of increased levels of total dissolved Cr in drilling No. 15 (8.3 - 37.9 μg/L). On the basis of our results degradation of groundwater quality was identified together with seasonal salinization; these two factors corroborate to the need for sustainable groundwater use especially in months with increased demands for water supplies.
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Roumpedaki E, Douladiris N, Papanaki A, Stamogiannou L, Maggina P, Manoussakis E, Vallianatou G, Papadopoulos NG, Xepapadaki P. A child with anaphylactic reaction by egg remedy applied to burn. Pediatr Allergy Immunol. 2014.
Creighton SM, Michala L, Mushtaq I, Yaron M. {Childhood surgery for ambiguous genitalia: glimpses of practice changes or more of the same?}. Psychology and Sexuality. 2014;5.Abstract
The Chicago consensus statement of 2005 was created at the point of cumulative criticisms and debates around the clinical practice of childhood genital surgery. It was drawn up at a time when it had become clearer that medically non-essential paediatric genital operations were associated with poor adult cosmetic outcomes and sexual functioning. However, data were not available for non-intervention. Therefore, parents and clinicians had no reliable information on how a child growing up with atypical genitalia might fare. The most positive recommendation in the consensus statement was the strong recommendation for decisions to be reached by a multidisciplinary team in collaboration with affected families. Importantly, the value of user groups was likewise formally acknowledged. For many services, there has been a sea change in the way surgeons work. Whilst some surgeons may continue with the standard practice of childhood genital surgery, it is becoming clearer that with adequate support, more individuals and families choose to postpone elective interventions. However, these are our observations only. Authoritative evidence must be based on high-quality multi-centre multidisciplinary research to prospectively monitor the long-term multiple outcomes of surgery and no surgery. There is as yet no obvious move towards such an endeavour. © 2013 © 2013 Taylor {&} Francis.
Gkotzamanidou M, Sfikakis PP, Kyrtopoulos SA, Bamia C, Dimopoulos MA, Souliotis VL. Chromatin structure, transcriptional activity and DNA repair efficiency affect the outcome of chemotherapy in multiple myeloma. British journal of cancer [Internet]. 2014;111(7):1293 - 1304. WebsiteAbstract
Melphalan is one of the most active chemotherapeutic agents in the treatment of multiple myeloma (MM). However, the mechanism underlying differential patient responses to melphalan therapy is unknown. METHODS :Chromatin structure, transcriptional activity and DNA damage response signals were examined following ex vivo treatment with melphalan of both malignant bone marrow plasma cells (BMPCs) and peripheral blood mononuclear cells (PBMCs) of MM patients, responders (n=57) or non-responders (n=28) to melphalan therapy. PBMCs from healthy controls (n=25) were also included in the study. In both BMPCs and PBMCs, the local chromatin looseness, transcriptional activity and repair efficiency of the transcribed strand (TS) were significantly higher in non-responders than in responders and lowest in healthy controls (all P<0.05). Moreover, we found that melphalan-induced apoptosis inversely correlated with the repair efficiency of the TS, with the duration of the inhibition of mRNA synthesis, phosphorylation of p53 at serine 15 and apoptosis rates being higher in responders than in non-responders (all P<0.001). Our findings provide a mechanistic basis for the link between DNA repair efficiency and response to melphalan therapy. Interestingly, the observation of these phenomena in PBMCs provides a novel approach for the prediction of response to anti-myeloma therapy.
Dalamaga M, Polyzos SA, Karmaniolas K, Chamberland J, Lekka A, Migdalis I, Papadavid E, Dionyssiou-Asteriou A, Mantzoros CS. Circulating fetuin-A in patients with pancreatic cancer: a hospital-based case-control study. Biomarkers. 2014;19(8):660-6.Abstract
CONTEXT: A proteomic analysis has proposed fetuin-A (alpha-2-HS-glycoprotein) as a new potential marker for pancreatic cancer (PC). OBJECTIVE: Circulating fetuin-A levels in patients with PC. METHODS: Serum fetuin-A was measured in 81 cases with PC and 81 matched controls before the initiation of any treatment. RESULTS: Serum fetuin-A was not independently associated with the presence of PC. Although there was a trend with higher fetuin-A levels across PC stages, comparisons of fetuin-A in patients within different PC prognostic stages revealed no differences. CONCLUSIONS: Circulating fetuin-A was similar between patients and controls and was not associated with the disease severity.
Matsangouras IT, Nastos PT, Bluestein HB, Sioutas MV. A climatology of tornadic activity over Greece based on historical records. International Journal of Climatology [Internet]. 2014;34(8):2538 - 2555. WebsiteAbstract
In this study, the climatology of tornadoes, waterspouts and funnel clouds over Greece is presented for the period 1709-2012. The climatology consists of two datasets. An historical dataset (1709-1999) is based on newspaper archives, historical archives, published tornado literature, administrative records and reports of Hellenic National Meteorological Service (HNMS). A recent dataset (2000-2012) is based on newspaper articles, eyewitness reports to the media, HNMS's reports and an open-ended online tornado report database which has been developed and maintained by the Laboratory of Climatology & Atmospheric Environment of the University of Athens. Altogether, 612 Greek tornadic events compose the climatology: 171 tornadoes, 374 waterspouts and 67 funnel clouds. Tornadic events during the past 13years (2000-2012) have occurred all over the Greek territory and there is frequent tornadic occurrence over north Crete and Corfu Island. Tornadoes are more frequent to occur over NW Peloponnesus followed by south parts of Corfu Island. However, waterspouts are more frequent over north Crete followed by Corfu Island. Tornadic monthly variability depicts a maximum during October, followed by September and November. October is the month with the highest tornado frequency, followed by November and July. The highest waterspout frequency month is September followed by October and December. Tornadoes most commonly develop during the warm time of the day, as more than 75% of all cases occur during 08:00-15:00hours UTC with a maximum at 12:00hours UTC. Waterspout frequency of occurrence has two maxima during the day, the first early in the morning (07:00-09:00hours UTC) and the second after the noon time period (14:00-15:00hours UTC). The dominant (27.7% of total cases) intensity of tornadoes in Greece is T4 based on the T-scale during the 300-year period (1709-2012); there have been at least 114 injured and 29 deaths. © 2013 Royal Meteorological Society.
Katodritou E, Terpos E, Symeonidis AS, Pouli A, Kelaidi C, Kyrtsonis M-C, Kotsopoulou M, Delimpasi S, Christoforidou A, Giannakoulas N, et al. Clinical features, outcome, and prognostic factors for survival and evolution to multiple myeloma of solitary plasmacytomas: A report of the Greek myeloma study group in 97 patients. American Journal of Hematology [Internet]. 2014;89(8):803 - 808. WebsiteAbstract
Solitary plasmacytoma (SP) is a rare plasma cell dyscrasia characterized by the presence of bone or extramedullary plasma cell tumors. The treatment of choice is local radiotherapy (R/T)±surgical excision. The role of adjuvant chemotherapy (C/T) or novel agents (NA) is uncertain. Data related to prognostic factors are inconclusive. Herein, we describe the clinical features, survival and prognosis of 97 consecutive patients, 65 with bone SP (SBP), and 32 with extramedullary SP (SEP), diagnosed and treated in 12 Greek Myeloma Centers. Objective response rate (≥PR) and complete response (CR) was 91.8% and 61.9%, respectively, and did not differ between the 2 groups. Overall, 38 patients relapsed or progressed to multiple myeloma (MM). After a median follow-up of 60 months, 5 and 10-year overall survival (OS) probability was 92% and 89% in SEP and 86% and 69% in SBP, respectively (P=0.2). The 5- and 10-year MM-free survival (MMFS) probability was 90% and 70% for patients with SEP vs. 59% and 50% for patients with SBP, respectively (P=0.054). Overall, the 5- and 10-year OS probability, plasmacytoma relapse-free survival (PRFS), progression-free survival and MMFS was 84% and 78%, 72% and 58%, 58% and 43%, and 70% and 59%, respectively. In the multivariate analysis, prolonged PRFS and young age were positive predictors of OS. Achievement of CR was the only positive predictor of PRFS. Immunoparesis was the only negative predictor of progression to MM. The addition of C/T or NA-based treatment increased toxicity without offering any survival advantage over R/T. Am. J. Hematol. 89:803-808, 2014. © 2014 Wiley Periodicals, Inc.
Haahtela T, Burbach GJ, Bachert C, Bindslev-Jensen C, Bonini S, Bousquet J, Bousquet-Rouanet L, Bousquet PJ, Bresciani M, Bruno A, et al. Clinical relevance is associated with allergen-specific wheal size in skin prick testing. Clin Exp Allergy. 2014;44(3):407-16.Abstract
BACKGROUND: Within a large prospective study, the Global Asthma and Allergy European Network (GA(2) LEN) has collected skin prick test (SPT) data throughout Europe to make recommendations for SPT in clinical settings. OBJECTIVE: To improve clinical interpretation of SPT results for inhalant allergens by providing quantitative decision points. METHODS: The GA(2) LEN SPT study with 3068 valid data sets was used to investigate the relationship between SPT results and patient-reported clinical relevance for each of the 18 inhalant allergens as well as SPT wheal size and physician-diagnosed allergy (rhinitis, asthma, atopic dermatitis, food allergy). The effects of age, gender, and geographical area on SPT results were assessed. For each allergen, the wheal size in mm with an 80% positive predictive value (PPV) for being clinically relevant was calculated. RESULTS: Depending on the allergen, from 40% (blatella) to 87-89% (grass, mites) of the positive SPT reactions (wheal size ≥ 3 mm) were associated with patient-reported clinical symptoms when exposed to the respective allergen. The risk of allergic symptoms increased significantly with larger wheal sizes for 17 of the 18 allergens tested. Children with positive SPT reactions had a smaller risk of sensitizations being clinically relevant compared with adults. The 80% PPV varied from 3 to 10 mm depending on the allergen. CONCLUSION: These 'reading keys' for 18 inhalant allergens can help interpret SPT results with respect to their clinical significance. A SPT form with the standard allergens including mm decision points for each allergen is offered for clinical use.
Siahanidou T, Margeli A, Tsirogianni C, Charoni S, Giannaki M, Vavourakis E, Charisiadou A, Papassotiriou I. Clinical value of plasma soluble urokinase-type plasminogen activator receptor levels in term neonates with infection or sepsis: a prospective study. Mediators Inflamm. 2014;2014:375702.Abstract
BACKGROUND: suPAR, the soluble form of the urokinase-type plasminogen activator receptor, has been identified as a biomarker of infection in adults but its properties in neonatal infection are not known. METHODS: Plasma suPAR levels were determined by ELISA in 47 term neonates with infection (19 bacterial and 28 viral) and in 18 healthy neonates as controls. Thirteen out of 47 infected neonates were septic. In all infected neonates, suPAR levels were repeated at 24 hours, 48 hours, 3-5 days, and 7-10 days following admission. RESULTS: Plasma suPAR levels were significantly increased in infected neonates upon admission, whereas they were highest in septic neonates, in comparison with controls (P < 0.001) and correlated positively with serum CRP levels (P = 0.001). At infection subsidence, suPAR concentrations decreased significantly in comparison with baseline (P < 0.001) but remained higher than in controls (P = 0.01). Receiver operating characteristic analysis resulted in significant areas under the curve for detecting either infected or septic neonates, but not for discriminating between bacterial and viral cause of infection. CONCLUSIONS: suPAR is a diagnostic biomarker of infection or sepsis in term neonates; however, it cannot discriminate bacterial from viral infections and also its utility for monitoring the response to treatment is questioned.
Papatryfon XL, Heliopoulos NS, Molchan IS, Zubeir LF, Bezemer ND, Arfanis MK, Kontos AG, Likodimos V, Iliev B, Romanos GE, et al. CO2 capture efficiency, corrosion properties, and ecotoxicity evaluation of amine solutions involving newly synthesized ionic liquids. Industrial and Engineering Chemistry Research [Internet]. 2014;53:12083-12102. WebsiteAbstract
The CO2 capture efficiency of nine newly synthesized ionic liquids (ILs), both in their pure states as well as in binary and ternary systems with water and amines, was investigated. The study encompassed ILs with fluorinated and tricyanomethanide anions as well as ILs that interact chemically with CO2 such as those with amino acid and acetate anions. Compared to amines, some of the novel ILs exhibited a majority of important advantages for CO2 capture such as enhanced chemical and thermal stabilities and negligible vapor pressure; the previous features counterbalance the disadvantages of lower CO2 absorption capacity and rate, making these ILs promising CO2 absorbents that could partially or totally replace amines in industrial scale processes. In addition to their ability to capture CO2, important issues including corrosivity and ecotoxicity were also examined. A thorough investigation of the capture efficiency and corrosion properties of several solvent formulations proved that some of the new ILs encourage future commercial-scale applications for appropriate conditions. ILs with a tricyanomethanide anion confirmed a beneficial effect of water addition on the CO2 absorption rate (ca. 10-fold) and capacity (ca. 4-fold) and high efficiency for corrosion inhibition, in contrast with the negative effect of water on the CO2 absorption capacity of ILs with the acetate anion. ILs with a fluorinated anion showed high corrosivity and an almost neutral effect of water on their efficiency as CO2 absorbents. ILs having amino acid anions presented a reduced toxicity and high potential to completely replace amines in solutions with water but, in parallel, showed thermal instability and degradation during CO2 capture. Tricyanomethanide anion-based ILs had a beneficial effect on the capture efficiency, toxicity, and corrosiveness of the standard amine solutions. As a consolidated output, we propose solvent formulations containing the tricyanomethanide anion-based ILs and less than 10 vol % of primary or secondary amines. These solvents exhibited the same CO2 capture performance as the 20-25 vol % standard amine solutions. The synergetic mechanisms in the capture efficiency, induced by the presence of the examined ILs, were elucidated, and the results obtained can be used as guidance for the design and development of new ILs for more efficient CO2 capture. © 2014 American Chemical Society.
Kontos AG, Likodimos V, Veziri CM, Kouvelos E, Moustakas N, Karanikolos GN, Romanos GE, Falaras P. CO2 captured in zeolitic imidazolate frameworks: Raman spectroscopic analysis of uptake and host-guest interactions. ChemSusChem [Internet]. 2014;7:1696-1702. WebsiteAbstract
Zeolitic imidazolate frameworks (ZIFs) exhibit enhanced selectivity and increased CO2 uptake due to the incorporation of functional imidazolate units in their structure as well as their extensive porosity and ring flexibility. In situ Raman investigation of a representative host compound, ZIF-69, in practical CO2 pressure and temperature regimes (0-10 bar and 0-64 °C) correlates well with corresponding macroscopic CO2 sorption data and shows clear clear spectroscopic evidence of CO2 uptake. Significant positive shift of the 159 cm-1 phenyl bending mode of the benzimidazole moiety indicates weak hydrogen bonding with CO 2 in the larger cavities of the ZIF matrix. Raman spectroscopy is shown to be an easy and sensitive tool for quantifying CO2 uptake, identifying weak host-guest interactions and elucidating CO2 sorption mechanism in ZIFs. Are you Raman enough? In situ Raman investigation of the interactions of zeolitic imidazolate frameworks (ZIFs) with CO2 in practical pressure and temperature regimes (0-10 bar and 0-64 °C) correlates well with corresponding macroscopic CO2 sorption data and shows clear spectroscopic evidence of CO2 uptake (see image). Raman is found to be an easy and sensitive tool for quantifying CO2 uptake, identifying weak host-guest interactions, and elucidating CO2 sorption mechanism in ZIFs. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Simou E, Papanikolaou D, Lykousis V, Nomikou P, Vassilakis E. Coastal and submarine instabilities distribution in the tectonically active SW margin of the Corinth Rift (Psathopyrgos, Achaia, Greece). EGU2014. 2014;16:9780.
Simou E, Papanikolaou D, Lykousis V, Nomikou P, Vassilakis E. Coastal and submarine instabilities distribution in the tectonically active SW margin of the Corinth Rift (Psathopyrgos, Achaia, Greece). In: EGU2014. Vol. 16. Vienna, Austria; 2014. pp. 9780. Poster
Simou E, Nomikou P, Lykousis V, Papanikolaou D, Vassilakis E. Coastal hazard related to landslide distribution derived from morphotectonic analysis (SW gulf of Corinth, Greece). 10th Congress of the Hellenic Geographical Society. 2014.
Tselekounis M, Orfanou G, Varoutas D. Coexistence of copper and fiber unbundling: Access charges and investment incentives. 2014.
Kontaxaki MI, Kattoulas E, Smyrnis N, Stefanis NC. Cognitive impairments and psychopathological parameters in patients of the schizophrenic spectrum. Psychiatrike= Psychiatriki. 2014;25:27–38.
Kamberidou I. Collective Intelligence Rises when Women Participate and the Myth that we can have it All ! [in Greek]. LWB- leading women in business, ICAP Group (www.icap.gr), pp. 126-127. Complementary book/edition in daily newspaper TA NEA, Saturday, December 20, 2014. [article in Greek] http://dir.icap.gr/mailimages/e-books/LWB/index.html Also see: http://www.i. 2014.Abstract
H Συλλογική Νοημοσύνη αυξάνεται όταν συμμετέχουν Γυναίκες και ο Μύθος ότι μπορούμε να τα κάνουμε όλα! (Καμπερίδου, 2014): Τι σημαίνει επαγγελματική επιτυχία σήμερα. Αυτό το άρθρο υποστηρίζει ότι η σημερινή οικονομία απαιτεί τις αποκαλούμενες θηλυκές δεξιότητες, τις οποίες υιοθετούν όλο και περισσότεροι άνδρες επιχειρηματίες, δεδομένου ότι εταιρείες που απασχολούν γυναίκες εμφανίζουν κατά μέσο όρο περισσότερα κέρδη και βιωσιμότητα (Sandberg 2013, Kamberidou 2013, Salamouris 2012, SheSpeaks 2011, Cox-Wittenberg & Maitland 2009). Tα αποτελέσματα διαδικτυακής έρευνας σε 3.963 γυναίκες υπογραμμίζουν ότι οι γυναίκες βρίσκονται ένα βήμα μπροστά από τους άντρες όσον αφορά στις επικοινωνιακές-κοινωνικές δεξιότητες. Ερευνητικά στοιχεία τεκμηριώνουν ότι η συλλογική νοημοσύνης μιας ομάδας αυξάνεται όταν συμμετέχουν περισσότερες γυναίκες. Οι  γυναίκες είναι λιγότερο προβλέψιμες και πιο εφευρετικές από τους άνδρες, πλεονεκτούν στο να προσελκύουν άτομα για συζήτηση, συνεργάζονται και προσαρμόζονται εύκολα στις ανάγκες των πελατών και  πολλές περιγράφουν τη δημιουργία της επιχείρησής τους ως τη δημιουργία μιας ομάδας. Ωστόσο, να προσπαθούμε να τα κάνουμε όλα (multitasking) και να περιμένουμε ότι όλα μπορούν να γίνουν σωστά είναι συνταγή απογοήτευσης, όπως  διαβεβαιώνει και η διευθύντρια του Facebook, Sheryl Sandberg  η οποία δείχνει πως επωφελούνται οι άνδρες όταν υποστηρίζουν και στηρίζουν τις γυναίκες στον  εργασιακό χώρο, και όχι μόνο. Προτείνει: «κάντε το σύντροφό σας  πραγματικό σύντροφο».    ---------------------------------------------------------------------- Καμπερίδου, Ειρήνη. (2014). H Συλλογική Νοημοσύνη αυξάνεται όταν συμμετέχουν Γυναίκες και ο Μύθος ότι μπορούμε να τα κάνουμε όλα! Collective Intelligence Rises when Women Participate and the Myth that we can have it All ! [in Greek]. LWB- leading women in business, ICAP Group (www.icap.gr), σελ.  126-127. Ενθετο/ΒΙΒΛΙΟ στην εφημερίδα ΤΑ ΝΕΑ, Σάββατο, 20 Δεκεμβρίου 2014, http://dir.icap.gr/mailimages/e-books/LWB/index.html  Also see: http://www.i. icap._ta_nea_20.12.2014._kamberidou.pdf
icap._ta_nea_20.12.2014._kamberidou.pdf
Loupis M, Papanikolaou N, Maliaris G, Kyritsis A, Nikolaidis VC. Combination of Building Applied PV Panels with Thermoelectric Generation and Geothermal Cooling. In: ; 2014.
Loupis M, Papanikolaou N, Maliaris G, Kyritsis A, Nikolaidis VC. Combination of Building Applied PV Panels with Thermoelectric Generation and Geothermal Cooling. In: MEDPOWER 2014. ; 2014.
Terpos E, Christoulas D, Kastritis E, Katodritou E, Papatheodorou A, Pouli A, Kyrtsonis M-C, Michalis E, Papanikolaou X, Gkotzamanidou M, et al. The combination of lenalidomide and dexamethasone reduces bone resorption in responding patients with relapsed/refractory multiple myeloma but has no effect on bone formation: Final results on 205 patients of the Greek myeloma study group. American Journal of Hematology [Internet]. 2014;89(1):34 - 40. WebsiteAbstract
The combination of lenalidomide plus dexamethasone (RD) is very effective for patients with relapsed/refractory myeloma. However, the effect of RD on bone metabolism has not been previously evaluated in these patients. To address this issue, we initially performed a retrospective study in 106 consecutive patients with relapsed or refractory myeloma who received RD. We measured the following bone indices on Cycle 1/Day 1 and then on Cycles 3 and 6/Day 28: dickkopf-1 (Dkk-1), sRANKL, osteoprotegerin (OPG), bone resorption markers (C-telopeptide of collagen type-I, CTX and TRACP-5b) and bone formation markers (bone-specific alkaline phosphatase-bALP and osteocalcin). RD produced a reduction of CTX only in responders, with no effect on bone formation. To validate these results, we then evaluated prospectively 99 patients who received either RD (n=50) or VRD (bortezomib + RD, n=49). RD reduced CTX, mainly in responders but showed no effect on bone formation, confirming the result of the retrospective study. However, the addition of bortezomib to RD (VRD arm) reduced Dkk-1, sRANKL/OPG, and CTX, while it increased bALP and OC after six cycles of therapy. These changes were irrespective of treatment response, which was similar between treatment arms. No skeletal-related events were observed in the VRD arm while two, nonresponding patients treated with RD developed a vertebral fracture. We conclude that RD reduces bone resorption only in responding patients with relapsed/refractory myeloma but has no effect on bone formation. Combination with bortezomib, which enhances bone formation, seems to be preferred for the management of myeloma patients with osteolytic disease. © 2013 Wiley Periodicals, Inc.
Macheras P. Comment and reply on: A randomized crossover trial investigating the ease of use and preference of two dry powder inhalers in patients with asthma of chronic obstructive pulmonary disease. EXPERT OPINION ON DRUG DELIVERY. 2014;11:823-824.
Alexe-Ionescu AL, Barbero G, Lelidis I. Comment on "modeling of electrode polarization for electrolytic cells with a limited ionic adsorption". Physical Review E - Statistical, Nonlinear, and Soft Matter Physics [Internet]. 2014;89:056401. Publisher's Version
Stratta P, Airoldi A, Battista M, Guglielmetti G, Radin E, Izzo C, Merlotti G, Quaglia M, Kastritis E, Terpos E, et al. Comment on: Think to prevent before than to treat renal impairment in multiple myeloma: Do not forget tubular damage mimicking Fanconi syndrome. Expert Opinion on Pharmacotherapy [Internet]. 2014;15(2):299 - 300. Website
Mitsi E. Commodifying Antiquity in Mary Nisbet’s Journey to the Ottoman Empire. Travel, Discovery, Transformation. 2014;1:45.
Passioti M, Maggina P, Megremis S, Papadopoulos NG. The Common Cold: Potential for Future Prevention or Cure. Current Allergy Asthma Reports. 2014;14.
Nikolaou VS, Chytas D, Babis GC. Common controversies in total knee replacement surgery: Current evidence. World J Orthop. 2014;5(4):460-8.Abstract
Total knee replacement (TKR) is a widely used operation that has radically improved the quality of life of millions of people during the last few decades. However, some technical details, concerning the surgical procedure and the rehabilitation following total knee arthroplasty, are still a matter of a strong debate. In this review of the literature, we have included the best evidence available of the last decade, in an effort to shed light on some of the most controversial subjects related to TKR surgery. Posterior-stabilized or cruciate-retaining prosthesis? To use a tourniquet during operation or not? Do patients need continuous passive motion for their post-surgery rehabilitation? To resurface patella or not? These are some of the most controversial topics that until now have been persistent dilemmas for the orthopedic surgeon. Results of this systematic review of the literature are highly controversial. These conflicting results are an indication that larger and more well conducted high quality trials are needed in order to gain more secure answers. At the same time, it is becoming apparent that a meticulous operative technique, respecting the soft tissue envelope and knowing the principles of alignment and soft tissue balancing, are some of the parameters that might contribute more to achieving the optimal results for the patients.
Tsakmakidis KL, Pickering TW, Hamm JM, Page AF, Hess O. Completely stopped and dispersionless light in plasmonic waveguides. Physical Review Letters [Internet]. 2014;112. WebsiteAbstract
We introduce a scheme where a time-dependent source excites "complex-frequency" modes in uniform plasmonic heterostructures, enabling complete and dispersionless stopping of light pulses, resilient to realistic levels of dissipative, radiative, and surface-roughness losses. Using transparent conducting oxides at telecommunication wavelengths we show how, without increasing optical losses, multiple light pulses can decay with time precisely at their injection points, unable to propagate despite the complete absence of barriers in front or behind them. Our results theoretically demonstrate extraordinary large light-deceleration factors (of the order of 1.5×107) in integrated nanophotonic media, comparable only to those attainable with ultracold atomic vapors or with quantum coherence effects, such as coherent population oscillations, in ruby crystals. © 2014 American Physical Society.
Aad G, others. {Comprehensive measurements of $t$-channel single top-quark production cross sections at $\sqrt{s} = 7$ TeV with the ATLAS detector}. Phys. Rev. D. 2014;90:112006.
Saville CWN, Lancaster TM, Stefanou ME, Salunkhe G, Lourmpa I, Nadkarni A, Boehm SG, Bender S, Smyrnis N, Ettinger U, et al. COMT Val158Met genotype is associated with fluctuations in working memory performance: converging evidence from behavioural and single-trial P3b measures. NeuroImage. 2014;100:489–497.
Stamopoulos D, Aristomenopoulou E, Lagogiannis A. Co/Nb/Co trilayers as efficient cryogenic spin valves and supercurrent switches: the relevance to the standard giant and tunnel magnetoresistance effects. SUPERCONDUCTOR SCIENCE & TECHNOLOGY. 2014;27(9).Abstract
Nowadays, Ferromagnetic/Superconducting/Ferromagnetic trilayers (FM/SC/FM TLs) are intensively studied. Here, based on (CoO-) Co/Nb/Co TLs of thin Nb interlayer (below 30 nm) we introduce two classes of low-T-c SC-based cryogenic devices, depending on the thickness of the Co outer layers and the presence of a CoO underlayer. An extended range of Co thickness (from 10 to 80 nm) was investigated and an underlayer of CoO was selectively employed, practically aiming to control in-plane and out-of-plane magnetization processes through utilization of shape anisotropy and exchange bias. To this effect magnetic force microscopy, magnetization and magnetoresistance data are presented. Ancillary atomic force microscopy and Rutherford back scattering data are presented, as well. CoO-Co/Nb/Co TLs of the first class have thin Co outer layers (10-30 nm) and are further assisted by the presence of a CoO underlayer to behave as efficient spin valves (Delta R/R-nor = 1.5% and Delta R/R-min = 2.4%) under the action of the FMs in-plane exchange fields; the effect is termed superconducting Spin-Valve Effect (sSVE). Co/Nb/Co TLs of the second class have thick Co outer layers (50-80 nm) and without the need of a CoO underlayer act as almost absolute supercurrent switches (Delta R/R-nor = 97.7% and Delta R/R-min = 28000%) under the action of FMs out-of-plane stray fields; the effect is termed superconducting Magneto-Resistance Effect (sMRE). The properties of these (CoO-) Co/Nb/Co TLs resemble the behavior of standard FM/normal-metal/FM and FM/insulator/FM TLs that exhibit the effects giant (GMR) and tunnel (TMR) magnetoresistance, respectively. Aiming to utilize the FM/SC/FM TLs studied here into cryogenic applications we thoroughly surveyed their operational H-T phase diagram and discuss how can be used to realize binary ('0'-'1') elemental devices for information management in both read heads and memory units. The underlying physical mechanisms responsible for the sSVE and sMRE observed in the two different classes of TLs, that is CoO-Co/Nb/Co and Co/Nb/Co, respectively and the technical requisites that the SC and FM ingredients should meet are discussed.
Athanasiou K, Mavrikaki E. Conceptual inventory of natural selection as a tool for measuring Greek University Students' evolution knowledge: differences between novice and advanced students. International Journal of Science Education. 2014;36:1262–1285.
Athanasiou K, Mavrikaki E. Conceptual inventory of natural selection as a tool for measuring Greek University Students' evolution knowledge: differences between novice and advanced students. International Journal of Science Education. 2014;36(8):1262-1285.
Athanasiou K, Mavrikaki E. Conceptual inventory of natural selection as a tool for measuring Greek University students' evolution knowledge: Differences between novice and advanced students. International Journal of Science Education. 2014;36:1262–1285.
Moisoglou I, Panagiotis P, Galanis P, Siskou O, Maniadakis N, Kaitelidou D. Conflict management in a Greek public hospital: Collaboration or avoidance. International journal of caring sciences. 2014;7(1):75-82.
Moisoglou I, Panagiotis P, Galanis P, Siskou O, Maniadakis N, Kaitelidou D. Conflict management in a Greek public hospital: Collaboration or avoidance. International journal of caring sciences. 2014;7:75–82.
Melea PI, Melakopoulos I, Kastritis E, Tesseromatis C, Margaritis V, Dimopoulos MA, Terpos E. Conservative treatment of bisphosphonate-related osteonecrosis of the jaw in multiple myeloma patients. International Journal of Dentistry [Internet]. 2014;2014. WebsiteAbstract
The use of intravenous bisphosphonates (pamidronate or zoledronic acid) is the cornerstone for the management of multiple myeloma-(MM-) related bone disease. However, osteonecrosis of the jaw (ONJ) is a rare, but sometimes difficult to manage, adverse effect of bisphosphonates therapy. A retrospective review of all MM patients who were treated with bisphosphonates in our department, from 2003 to 2013, and developed ONJ was performed. According to inclusion criteria, 38 patients were studied. All these patients were treated as conservatively as possible according to the American Association of Oral and Maxillofacial Surgeons criteria. Patients were managed with observation, oral antibacterial mouth rinse with chlorhexidine, oral antibiotics, pain control with analgesics, nonsurgical sequestrectomy with or without simultaneous administration of antibiotics, or major surgery with or without antibiotics. Healing of the lesions was achieved in 23 (60%) patients who were treated with conservative measures; the median time to healing was 12 months (95% CI: 4-21). The number of bisphosphonates infusions influenced the time to healing: the median time to healing for patients who received <16 infusions was 7 months and for those with >16 infusions was it 14 months P=0.017. We conclude that a primarily nonsurgical approach appears to be a successful management strategy for bisphosphonate-related ONJ. © 2014 Pelagia I. Melea et al.
Hatzimoysis A. Consistency in the Sartrean Analysis of Emotion. Analysis. 2014;74:81-83. Consistency in the Sartrean analysis of emotion.pdf
Anasontzis GE, Kourtoglou E, Mamma D, Villas-Boâs SG, Hatzinikolaou DG, Christakopoulos P. Constitutive homologous expression of phosphoglucomutase and transaldolase increases the metabolic flux of Fusarium oxysporum. Microbial Cell Factories [Internet]. 2014;13:Article 43. Publisher's VersionAbstract
Background: Fusarium oxysporum is among the few filamentous fungi that have been reported of being able to directly ferment biomass to ethanol in a consolidated bioprocess. Understanding its metabolic pathways and their limitations can provide some insights on the genetic modifications required to enhance its growth and subsequent fermentation capability. In this study, we investigated the hypothesis reported previously that phosphoglucomutase and transaldolase are metabolic bottlenecks in the glycolysis and pentose phosphate pathway of the F. oxysporum metabolism. Results: Both enzymes were homologously overexpressed in F. oxysporum F3 using the gpdA promoter of Aspergillus nidulans for constitutive expression. Transformants were screened for their phosphoglucomutase and transaldolase genes expression levels with northern blot. The selected transformant exhibited high mRNA levels for both genes, as well as higher specific activities of the corresponding enzymes, compared to the wild type. It also displayed more than 20 and 15% higher specific growth rate upon aerobic growth on glucose and xylose, respectively, as carbon sources and 30% higher biomass to xylose yield. The determination of the relative intracellular amino and non-amino organic acid concentrations at the end of growth on glucose revealed higher abundance of most determined metabolites between 1.5- and 3-times in the recombinant strain compared to the wild type. Lower abundance of the determined metabolites of the Krebs cycle and an 68-fold more glutamate were observed at the end of the cultivation, when xylose was used as carbon source. Conclusions: Homologous overexpression of phosphoglucomutase and transaldolase in F. oxysporum was shown to enhance the growth characteristics of the strain in both xylose and glucose in aerobic conditions. The intracellular metabolites profile indicated how the changes in the metabolome could have resulted in the observed growth characteristics.
mcf_2014_13_43.pdf
Kassaras I, Kapetanidis V, Karakonstantis A, Kouskouna V, Ganas A, Chouliaras G, Drakatos G, Moshou A, Mitropoulou V, Argyrakis P, et al. Constraints on the dynamics and spatio-temporal evolution of the 2011 Oichalia seismic swarm (SW Peloponnesus, Greece). Tectonophysics [Internet]. 2014;614:100 - 127. Publisher's VersionAbstract
In this paper, we present a detailed study of a shallow seismic swarm which took place in the area of Oichalia (SW Peloponnesus), between August and December 2011. The seismic crisis started on 14/8/2011 with an Mw=4.8 earthquake and was followed by more than 1600 events, several of which having magnitude over 4.0. The activity was recorded by local temporary and regional permanent seismic stations. Thousands of records were collected and routinely analyzed. P- and S-wave arrival times were manually picked and incorporated in the HYPOINVERSE algorithm together with a new optimum local velocity model. Hypocentral solutions were improved by applying a double-difference method. Focal mechanisms show that the activated fault zone is dominated by dip-slip normal faulting, trending NNW–SSE, with the average T-axes orientation being N70°E, consistent with regional tectonics. We have investigated towards stress triggering and fluid diffusion, by employing Coulomb stress transfer, spatio-temporal and Frequency–Magnitude Distribution (FMD) analyses. The negligible Coulomb stress transfer and seismicity rate changes that were calculated imply for a stress deficit in the broader study area, hence an external triggering mechanism is required to justify the observed pattern. The b-values increase towards the SSE, compatible with the similarly directed migration of seismicity, showed that the Oichalia swarm could possibly be adapted to an Epidemic Type Aftershock Sequence model (ETAS). Fluid diffusion is reflected in the spatio-temporal hypocenter migration. Clustering analysis, combined with the temporal distribution of b-values, has shown that the swarm evolved in three major phases, the first two being initiated by major events, which were probably triggered externally due to fluid injection that brought the seismogenic volume into a critical state, likely followed by afterslip. The last phase signified a relaxation period, with dispersed seismicity throughout the area and the b-values gently diminishing towards unity.
article_16_oixalia_2014.pdf
Kassaras I, Kapetanidis V, Karakonstantis A, Kouskouna V, Ganas A, Chouliaras G, Drakatos G, Moshou A, Mitropoulou V, Argyrakis P, et al. Constraints on the dynamics and spatio-temporal evolution of the 2011 Oichalia seismic swarm (SW Peloponnesus, Greece). Tectonophysics [Internet]. 2014;614:100 - 127. Publisher's VersionAbstract
In this paper, we present a detailed study of a shallow seismic swarm which took place in the area of Oichalia (SW Peloponnesus), between August and December 2011. The seismic crisis started on 14/8/2011 with an Mw=4.8 earthquake and was followed by more than 1600 events, several of which having magnitude over 4.0. The activity was recorded by local temporary and regional permanent seismic stations. Thousands of records were collected and routinely analyzed. P- and S-wave arrival times were manually picked and incorporated in the HYPOINVERSE algorithm together with a new optimum local velocity model. Hypocentral solutions were improved by applying a double-difference method. Focal mechanisms show that the activated fault zone is dominated by dip-slip normal faulting, trending NNW–SSE, with the average T-axes orientation being N70°E, consistent with regional tectonics. We have investigated towards stress triggering and fluid diffusion, by employing Coulomb stress transfer, spatio-temporal and Frequency–Magnitude Distribution (FMD) analyses. The negligible Coulomb stress transfer and seismicity rate changes that were calculated imply for a stress deficit in the broader study area, hence an external triggering mechanism is required to justify the observed pattern. The b-values increase towards the SSE, compatible with the similarly directed migration of seismicity, showed that the Oichalia swarm could possibly be adapted to an Epidemic Type Aftershock Sequence model (ETAS). Fluid diffusion is reflected in the spatio-temporal hypocenter migration. Clustering analysis, combined with the temporal distribution of b-values, has shown that the swarm evolved in three major phases, the first two being initiated by major events, which were probably triggered externally due to fluid injection that brought the seismogenic volume into a critical state, likely followed by afterslip. The last phase signified a relaxation period, with dispersed seismicity throughout the area and the b-values gently diminishing towards unity.
article_16_oixalia_2014.pdf
Kenourgios, D. DD. Contagion effects of the Global Financial Crisis in US and European real economy sectors. Panoeconomicus [Internet]. 2014;61:275-288. Website
Bella S. A contrastive study of apologies performed by Greek native speakers and learners of Greek as a foreign language. Pragmatics [Internet]. 2014;24(4):679-713. Publisher's Version
Alexopoulos J. The contribution of the geo-electrical parameters distribution in the investigation of the paleo geographical evolution of the deltaic plain of Pineios river (Thessaly). 10th Congress of the Hellenic Geographical Society [Internet]. 2014. pdfAbstract
In the region of the deltaic field of Pinios River in Thessaly and under an applied geoenvironmental research, a preliminary geophysical survey was developed. In this direction, an attempt was made to develop a grid of positions-measurements that would be able to cover the whole field in order to adumbrate the general “image” of the geoelectric parameters. From the conducted bibliographic research, it seems that it is the first time that such a coordinated and extensive geophysical survey has been made in the area. In this project and in the direction of the evaluation of the geoelectric parameters of lithology present in the deltaic area, displays of the horizontal and vertical distribution of electrical resistivity are presented. This knowledge will contribute to the emergence of new data and information on the subsurface structure of the field of the deltaic plain. The geoelectrical method with the Sclumberger array was applied, for the vertical investigation of the distribution of electrical resistivity, in order to investigate the geoelectrical parameters. These arrays are best suited, as a preliminary subsurface investigation method in such geo-environments. Thirty seven soundings were developed in an almost 'normalized' grid, aiming to the greatest possible depth of investigation. Towards this direction, despite the very difficult condition of accessibility, the development of the electrode current (AB or C1C2) reached 1.100 meters, with an investigation depth >250 meters. From the sections and the constructed maps, conductive geoelectric distributions structures detected, with a resistivity ranging in 5-30 Ohm.m, in almost the whole subsurface field of deltaic plain. From this general view, seems to differentiate the coastal zone for shallow depths (<4.5 m) of investigation, the regions of the southern part of the deltaic plain with larger resistivity values for large depths (> 100 m) and the western region (Pyrgetos), with generally high values even from the shallow depths of investigation. Finally, the overall picture of the distribution of the geoelectric parameters in the field of study appears to outline potential area of the palaeogeographic development of the Pinios River delta.
Likodimos V, Steriotis TA, Papageorgiou SK, Romanos GE, Marques RRN, Rocha RP, Faria JL, Pereira MFR, Figueiredo JL, Silva AMT, et al. Controlled surface functionalization of multiwall carbon nanotubes by HNO3 hydrothermal oxidation. Carbon [Internet]. 2014;69:311-326. WebsiteAbstract
Controlled surface functionalization is demonstrated by nitric acid hydrothermal oxidation on multiwall carbon nanotubes (MWCNTs). The formation and evolution of oxygen functional groups were systematically investigated as a function of the HNO3 concentration on MWCNTs with different structural and morphological characteristics, employing temperature-programmed desorption coupled with mass spectrometry, thermogravimetry and differential scanning calorimetry, Raman spectroscopy and N2 porosimetry analysis. Hydrothermal treatment provides controlled MWCNT modification by specific oxygen functionalities at amounts determined by the morphology, texture and crystallinity of the pristine materials. Hydrothermal oxidation competes well with the harsh boiling nitric acid treatment regarding the total amount of oxygen functionalities, while requiring much lower amounts of oxidizing agent and, most importantly, reducing amorphous carbon deposits on the MWCNT surface, a major drawback of aggressive liquid phase oxidation methods. Detailed pore structure analysis revealed a progressive increase of the surface area upon hydrothermal functionalization, whereas the mesopore structure varied consistently with the intrinsic MWCNT properties related to the packing of the nanotube bundles and the reduction of amorphous carbon. These advantageous features render nitric acid hydrothermal oxidation an efficient functionalization process to fine tune and optimize the surface chemistry of MWCNTs for target applications, circumventing the need for additional purification post-processing. © 2013 Elsevier Ltd. All rights reserved.
Tzanakaki A, Anastasopoulos MP, Peng S, Rofoee B, Yan Y, Simeonidou D, Landi G, Bernini G, Ciulli N, Riera JF, et al. A converged network architecture for energy efficient mobile cloud computing. In: 2014 International Conference on Optical Network Design and Modeling, ONDM 2014. ; 2014. pp. 120-125. Website
Tzanakaki A, Anastasopoulos MP, Peng S, Rofoee B, Yan Y, Simeonidou D, Landi G, Bernini G, Ciulli N, Riera JF, et al. A converged network architecture for energy efficient mobile cloud computing. In: ; 2014. pp. 120 - 125. Website
Damaskos D, Kolovou V, Kostakou P, Anagnostopoulou K, Mihas K, Diakoumakou O, Cokkinos D, Kolovou G. Correlation between metabolic syndrome criteria and polymorphisms concerning lipid metabolism, hypertension and vascular disease. Atherosclerosis. 2014;235:e115.
Stamopoulos D, Mpakirtzi N, Dimitratou V, Griveas I, Lianos E, Grapsa E. CORRELATION BETWEEN RED BLOOD CELL MEMBRANE DECONSTRUCTIONS AND ADMINISTRATION OF EXOGENOUS ERYTHROPOIETIN IN PATIENTS ON HAEMODIALYSIS. NEPHROLOGY DIALYSIS TRANSPLANTATION. 2014;29(51st Congress of the European-Renal-Association(ERA)/European-Dialysis-and-Transplant-Association (EDTA):495 - 495.
Bakodimos G, Kasampalis A, Drikos S, Dimitriadis J. The correlation between the type of pass after float serve and the efficiency of attack in men’s elite volleyball. In: 22nd International Congress of Physical Education & Sport. Democritus University of Thrace,; 2014. pp. 206-211.Abstract
The changes of regulations affect the development of all sports. In volleyball one of the key changes in the 1998 regulations was that players were allowed to pass the float serve with upper head pass technique. The outcome of this change was the use of this as main technique by numerous players mostly in float serve. At the last congress of the FIVB proposed repealing regulation, ' as in volleyball on sand, but was not accepted. Reception serve is part of the syndrome 1 Volleyball and important to the success of attack, but also for the game success, while the speed of the attack in Volleyball Men is a predictor for the final result of the game.The purpose of this research is to highlight the differences in the effectiveness of the attack syndrome1 Volleyball depending on the type of pass to the float serve or jump from the ground. The data comes from recording the technical skill of the pass after float serve (N >15.500) of 176 games performance teams (88 races for 2 groups) of the season 2012‐13 A1 National Men category . The technical skills are assessed (dropping to 5‐level ordinal scale) the type of pass used (with U.h or L.h) , the zone in which the passer is located (in nominal scale six levels) , the zone of which the attack took place (in nominal range 5 levels) ,and the efficiency of theattack (on regular 3‐level scale) . The interatomic control of reliability was tested with the log Cohen K coefficient and weighted Coehn K.For the statistical processing of data applied logistic regression by the method of maximum probabilities. Results showed that all the passes with L.h technique were more than the total passes with UH technique and efficacy of attack after the L.h is better, than the effectiveness of the attack after the UH pass technique.
Valla K, Halazonetis DJ. Correlation of 2D:4D digit ratio and craniofacial shape in prepubertal children. Am J Hum Biol. 2014;26(3):337-46.Abstract
OBJECTIVES: The 2D:4D ratio is sexually dimorphic and is considered a proxy of prenatal androgen levels, or, according to recent evidence, is related to genes involved in ocular and palate development. Our aim was to investigate correlation between the 2D:4D ratio and the shape of the craniofacial skeleton in a population of prepubertal children. METHODS: We conducted a cross-sectional study in a group of 58 male and 59 female prepubertal children aged 7-12 years. Craniofacial shape was evaluated using 15 skeletal landmarks on lateral cephalometric radiographs and fingers were measured with a computer-assisted procedure that involved tracing the finger outline. Geometric morphometric analysis was applied to the craniofacial landmarks and multivariate regression between digit ratios and craniofacial shape was computed in shape space and form space. RESULTS: The male 2D:4D ratio was smaller than the female ratio (Cohen's d: 0.275 left hand, 0.126 right hand), but the difference was not statistically significant. Craniofacial shape did not show sexual dimorphism, but males were larger than females. No correlation was found between digit ratio and craniofacial shape in prepubertal children, either for the whole sample or for any of the two sex groups. CONCLUSIONS: As several factors might be involved in the development and growth of both the craniofacial complex and fingers, the 2D:4D ratio, a putative proxy for fetal sex-hormone levels, is probably unable to impose a measurable effect within the variation of a normal population. Future research needs to examine an adult sample for potential covariation arising after the pubertal growth spurt.
Dionysia S, Athanasios T, Gregory P, Dimitris D, Antigoni H, Cokkinos DV, Maria K. The correlation of ischemia with myocardial dysfunction during exercise testing: P345. European Journal of Heart Failure. 2014;16.
Evelpidou N, Dimitriou E, Papadaki C, Stamatakis M, Ntoanidis L, Koutsomichou I, Anastasatou M, Karkani A. A correlation of the structure and chemical composition of the habitat sediments with the ecological flow of Acheloos river in Trikala Prefecture, Thessaly, Greece. In: 10th International Congress of the Hellenic Geographical Society. Thessaloniki, Greece; 2014.Abstract
During the implementation of fieldwork for the “Ecoflow” Cooperation project, in Acheloos River, Trikala Prefecture, Central Greece, 10 unstructured sediment samples were extracted from 3 sites along the river banks for measurements and analysis. The samples were taken from the areas of Drosochori (DR 1, DR 2 & DR 3), Aspropotamos (ASP 1 & ASP 3) and Mesochora (KOR 1, KOR 2, MES 1, MES 2, & MES 4). For granulometric analysis of the samples, the Folk &Ward method (2222) was used. As it was resulted, all samples are classified as gravelly sands to sandy gravels, poorly to very poorly sorted, very coarse to very fine skewed and platykurtic to mesokurtic. The ΧRD mineralogical analysis showed that in all the samples quartz is the major component. Calcite or dolomite [one sample] content is ranging between major through medium values. The presence of the magnesian calcite, which was found in two samples, is most likely attributed to biological sources (i.e. epiphytes, shells, etc), as commonly occur white colonies of small coral-like assemblages stack on the permanently wet pebbles observed close to the river banks. Sodium feldspars predominantly albite] are present in half of the samples as medium component and as trace component in the other half. By contrast, potassium feldspars [mainly orthoclase] are always present in minor/trace amounts. The presence of clay minerals, when considered as a group, is that of a medium or minor component. As the clay minerals content increases, the water has more suspended particles, so the river's turbidity during stormy events is strongly influenced. The higher content of clay minerals in the samples of Mesochora (downstream) indicates a different source of sediment from that of the other samples. By comparing the mineralogical analysis results with river water chemical analysis results from the same sampling sites, it becomes evident that the analyzed sediments do not provide the river waters with ions, as can be deduced from the low content of alkalies and alkaline earth metals. Sulphates and chlorides were detected in trace amounts in the water samples, whereas no sulphate minerals or halides there were detected in the sediments analysed. It is therefore concluded that there is not any buried evsaporite source in the vicinity of the sampling areas. In addition, the significantly low content of nitrates, nitrites and ammonia demonstrate the nonexistent contamination from biogenic factors. Another factor that plays a crucial role in the ecological status of the river is the availability of sediment for the development and maintenance of suitable habitats for the icthyofauna. The composition and structure of sediments affect their transportation and deposition behaviour which impacts the substrate of the river habitats. To assess this aspect in the study area, habitat suitability curves for specific fish species have been used that describe the best substrate for the necessary river habitats to support the breeding and reproduction of the particular fish species. The representation of the sample sediments in the substrate types required has been estimated by combining the results from habitat mapping, suitability curves and the sediment analyses. The results indicated that the type of material available in the particular river segments is appropriate for the maintenance and development of the habitat types that are required for a good ecological status.
Rigopoulos I, Tsikouras B, Pomonis P, Hatzipanagiotou K. Correlations between petrographic and geometrical properties of ophiolitic aggregates from Greece. Bulletin of Engineering Geology and the Environment. 2014;73:1–12.
Varotsos C, Ondov J, Tzanis C, Öztürk F, Nelson M, Ke H, Christodoulakis J. Corrigendum to "An observational study of the atmospheric ultra-fine particle dynamics" [Atmos. Environ. 59 (2012) 312-319]. Atmospheric Environment [Internet]. 2014;94:817. Website
Molchan IS, Thompson GE, Lindsay R, Skeldon P, Likodimos V, Romanos GE, Falaras P, Adamova G, Iliev B, Schubert TJS. Corrosion behaviour of mild steel in 1-alkyl-3-methylimidazolium tricyanomethanide ionic liquids for CO2 capture applications. RSC Advances [Internet]. 2014;4:5300-5311. WebsiteAbstract
{The corrosion behaviour of mild steel (MS) was systematically investigated as a function of the alkyl chain length in the cation of 1-alkyl-3- methylimidazolium tricyanomethanide ([Cnmim]TCM
Giorga E, Mantas J. Cost of health services using the Activity Based Costing (ABC) Model: A case study at NIMTS Hospital. Stud Health Technol Inform. 2014;202:317.
Cayatte V, Vlahakis N, Matsakos T, Lima JJG, Tsinganos K, Sauty C. Counter-rotation in Relativistic Magnetohydrodynamic Jets. [Internet]. 2014;788:L19. WebsiteAbstract
Young stellar object observations suggest that some jets rotate in the opposite direction with respect to their disk. In a recent study, Sauty et al. showed that this does not contradict the magnetocentrifugal mechanism that is believed to launch such outflows. Motion signatures that are transverse to the jet axis, in two opposite directions, have recently been measured in M87. One possible interpretation of this motion is that of counter-rotating knots. Here, we extend our previous analytical derivation of counter-rotation to relativistic jets, demonstrating that counter-rotation can indeed take place under rather general conditions. We show that both the magnetic field and a non-negligible enthalpy are necessary at the origin of counter-rotating outflows, and that the effect is associated with a transfer of energy flux from the matter to the electromagnetic field. This can be realized in three cases: if a decreasing enthalpy causes an increase of the Poynting flux, if the flow decelerates, or if strong gradients of the magnetic field are present. An illustration of the involved mechanism is given by an example of a relativistic magnetohydrodynamic jet simulation.
Cayatte V, Vlahakis N, Matsakos T, Lima JJG, Tsinganos K, Sauty C. Counter-rotation in Relativistic Magnetohydrodynamic Jets. [Internet]. 2014;788:L19. WebsiteAbstract
Young stellar object observations suggest that some jets rotate in the opposite direction with respect to their disk. In a recent study, Sauty et al. showed that this does not contradict the magnetocentrifugal mechanism that is believed to launch such outflows. Motion signatures that are transverse to the jet axis, in two opposite directions, have recently been measured in M87. One possible interpretation of this motion is that of counter-rotating knots. Here, we extend our previous analytical derivation of counter-rotation to relativistic jets, demonstrating that counter-rotation can indeed take place under rather general conditions. We show that both the magnetic field and a non-negligible enthalpy are necessary at the origin of counter-rotating outflows, and that the effect is associated with a transfer of energy flux from the matter to the electromagnetic field. This can be realized in three cases: if a decreasing enthalpy causes an increase of the Poynting flux, if the flow decelerates, or if strong gradients of the magnetic field are present. An illustration of the involved mechanism is given by an example of a relativistic magnetohydrodynamic jet simulation.
Georgantzinos SK, Anifantis NK. Crack closure. Encyclopedia of Thermal Stresses (edit. RB Hetnarski). Springer Netherlands. 2014;774(779).
Georgantzinos SK, Anifantis NK. Crack closure,[In:] Encyclopedia of Thermal Stresses, RB Hetnarski. 2014.
Gargallo IS. Creencias y actitudes de profesores y alumnos griegos de español ante las técnicas de corrección en la interacción oral: estudio comparativo intragrupos/Beliefs and Attitudes of Teachers and Greek Learners of Spanish towards Techniques of Correction i. Didáctica: Lengua y Literatura. 2014;26:429-446.
Petrakis PE, Kostis PC, Valsamis DG. The crisis and the setting of the recovery. In: The Rebirth of the Greek Labor Market: Building Toward 2020 After the Global Financial Meltdown. ; 2014. pp. 3-18.
Petrakis PE, Kostis PC, Valsamis DG. The Crisis and the Setting of the Recovery. In: The Rebirth of the Greek Labor Market. Palgrave Macmillan {US}; 2014. pp. 3–18. Website
Kostić N, Dotsikas Y, Malenović A. Critical review on the analytical methods for the determination of zwitterionic antiepileptic drugs-Vigabatrin, Pregabalin, and Gabapentin - In bulk and formulations. Instrumentation Science and Technology [Internet]. 2014;42(4):486 - 512. Website
Savvatianos S, Konstantinopoulos A, Borga A, J L, Borres M, Manousakis E, NG P. Cross- reactivity between Anacardiaceae (cashew/pistachio) and Rutaceae (orange/lemon) seeds. Allergy. 2014;69:553.
Skandalis SS, Afratis N, Smirlaki G, Nikitovic D, Theocharis AD, Tzanakakis GN, Karamanos NK. Cross-talk between estradiol receptor and EGFR/IGF-IR signaling pathways in estrogen-responsive breast cancers: focus on the role and impact of proteoglycans. Matrix BiolMatrix Biol. 2014;35:182-93.Abstract
In hormone-dependent breast cancer, estrogen receptors are the principal signaling molecules that regulate several cell functions either by the genomic pathway acting directly as transcription factors in the nucleus or by the non-genomic pathway interacting with other receptors and their adjacent pathways like EGFR/IGFR. It is well established in literature that EGFR and IGFR signaling pathways promote cell proliferation and differentiation. Moreover, recent data indicate the cross-talk between ERs and EGFR/IGFR signaling pathways causing a transformation of cell functions as well as deregulation on normal expression pattern of matrix molecules. Specifically, proteoglycans, a major category of extracellular matrix (ECM) and cell surface macromolecules, are modified during malignancy and cause alterations in cancer cell signaling, affecting eventually functional cell properties such as proliferation, adhesion and migration. The on-going strategies to block only one of the above signaling effectors result cancer cells to overcome such inactivation using alternative signaling pathways. In this article, we therefore review the underlying mechanisms in respect to the role of ERs and the involvement of cross-talk between ERs, IGFR and EGFR in breast cancer cell properties and expression of extracellular secreted and cell bound proteoglycans involved in cancer progression. Understanding such signaling pathways may help to establish new potential pharmacological targets in terms of using ECM molecules to design novel anticancer therapies.
Manitakis N, Michail M. Cypriot Emigration to the United States of America (1910-1930)’. Chronos. Revue d'Histoire de l'Université de Balamand [Internet]. 2014;30:99-143. Publisher's Version
Gil-De-Gómez L, Astudillo AM, Guijas C, Magrioti V, Kokotos G, Balboa MA, Balsinde J. Cytosolic group IVA and calcium-independent group VIA phospholipase A2s act on distinct phospholipid pools in zymosan-stimulated mouse peritoneal macrophages. Journal of Immunology. 2014;192:752-762.Abstract
Phospholipase A2s generate lipid mediators that constitute an important component of the integrated response of macrophages to stimuli of the innate immune response. Because these cells contain multiple phospholipase A2 forms, the challenge is to elucidate the roles that each of these forms plays in regulating normal cellular processes and in disease pathogenesis. A major issue is to precisely determine the phospholipid substrates that these enzymes use for generating lipid mediators. There is compelling evidence that group IVA cytosolic phospholipase A2 (cPLA2α) targets arachidonic acid–containing phospholipids but the role of the other cytosolic enzyme present in macrophages, the Ca2+-independent group VIA phospholipase A2 (iPLA2β) has not been clearly defined. We applied mass spectrometry–based lipid profiling to study the substrate specificities of these two enzymes during inflammatory activation of macrophages with zymosan. Using selective inhibitors, we find that, contrary to cPLA2α, iPLA2β spares arachidonate-containing phospholipids and hydrolyzes only those that do not contain arachidonate. Analyses of the lysophospholipids generated during activation reveal that one of the major species produced, palmitoyl-glycerophosphocholine, is generated by iPLA2β, with minimal or no involvement of cPLA2α. The other major species produced, stearoyl-glycerophosphocholine, is generated primarily by cPLA2α. Collectively, these findings suggest that cPLA2α and iPLA2β act on different phospholipids during zymosan stimulation of macrophages and that iPLA2β shows a hitherto unrecognized preference for choline phospholipids containing palmitic acid at the sn-1 position that could be exploited for the design of selective inhibitors of this enzyme with therapeutic potential.
Kyritsis A, Maliaris G, Papanikolaou N, Loupis M, Tatakis. D1.1 : Report on the performance characteristics and the technical details that have been determined. 2014.
Loupis M. D1.4: Report of the possible solutions, including the simulation model-justification of the possible solution. 2014.
Demetriou IC, Papakonstantinou SS. Data engineering by the best L1 convex data fitting method. In: Lecture Notes in Engineering and Computer Science: Proceedings of The World Congress on Engineering 2014. S.I. Ao, L. Gelman, D.W.L. Hukins, A. Hunter, A.M. Korsunsky, Editors. World Scientific, New Jersey; 2014. pp. 233-246.
Dead archaeologists, buried gods: archaeology as an agent of modernity in Greece. In: Tziovas D Re-imagining the Past. Antiquity and Modern Greek Culture. Oxford: Oxford University Press; 2014. pp. 147-164.
Özsoy E, Sofianos S, Gertman I, Mantziafou A, Aydoğdu A, Georgiou S, Tutsak E, Lascaratos A, Hecht A, Latif MA. Deep-Water Variability and Interbasin Interactions in the Eastern Mediterranean Sea.; 2014 pp. 85-112. Website
Özsoy E, Sofianos S, Gertman I, Mantziafou A, Aydogdu A, Georgiou S, Tutsak E, Lascaratos A, Hecht A, Latif MA. Deep-water variability and interbasin interactions in the eastern mediterranean sea. Geophysical Monograph Series [Internet]. 2014;202:85-112. Website
Zhang G, Nadagouda MN, O'Shea K, El-Sheikh SM, Ismail AA, Likodimos V, Falaras P, Dionysiou DD. Degradation of cylindrospermopsin by using polymorphic titanium dioxide under UV-Vis irradiation. Catalysis Today [Internet]. 2014;224:49-55. WebsiteAbstract
The frequent occurrence of cyanobacterial harmful blooms due to eutrophication necessitates the development of appropriate water treatment technologies for the released cyanotoxins. In this study, nanoparticles composed of anatase-brookite-rutile polymorphic titanium dioxide (PM-TiO2) were synthesized using a modified sol-gel method with a low temperature oil bath for the photocatalytic degradation of cylindrospermopsin (CYN), an important cyanotoxin that has been only little explored with respect to water treatment technologies. The physiochemical properties of synthesized PM-TiO2 nanoparticles, such as the formation of heteronanostructure (with 66% anatase, 22% brookite and 12% rutile), high surface area (207 m2/g), small particle size (∼5 nm), and bandgap (Eg = 3.0 eV), endow PM-TiO2 to be an effective photocatalyst for CYN treatment under UV-Vis irradiation. Moreover, the impacts of certain process parameters (i.e. photocatalyst loading, pH and presence of natural organic matter (NOM)) were examined and discussed in detail. It was found that the presence of NOM decreased the observed reaction rate constants by 52% and 95% compared to clean water samples when 2 and 10 mg/L NOM were applied, respectively. In particularly, when two natural water samples from East Fork Lake and Toledo Water Plant were applied as the matrices in the photocatalytic experiments, the degradation rate constants were reduced by 90% and 75%, respectively. This work demonstrates that the polymorphic TiO2 containing three phases can be effective photocatalyst for cyanotoxin treatment, however, the degradation kinetics are inhibited significantly in the presence of NOM. Therefore, pretreatment is necessary to remove NOM before the photocatalytic treatment of surface water containing CYN. © 2013 Elsevier B.V.
Stamopoulos D, Zeibekis M, Vertsioti G, Zhang SJ. Degradation of the remanent ferromagnetic state under the action of ferroelectric relaxation processes in Co/(1-x)PMN-xPT/Co hybrids: Possible implications on cryogenic and room-temperature applications. JOURNAL OF APPLIED PHYSICS. 2014;116(8).Abstract
Low-dimensional hybrid structures of heterogeneous constituents usually exhibit abnormal properties, a fact that makes such hybrids attractive for various cryogenic and room-temperature applications. Here, we studied Co/(1 - x)Pb(Mg1/3Nb2/3)O-3-xPbTiO(3)/Co (Co/PMN-xPT/Co) with x = 0.29 and 0.30, specifically focusing on the evolution of the remanent ferromagnetic state, m(rem) of the Co outer layers in the whole temperature range from 300K down to 10 K, upon application of an external electric field, E-ex. We observed that m(rem) was vulnerable to degradation through the occurrence of electric field-induced magnetic instabilities (EMIs) that appeared only when E-ex not equal 0 kV/cm and were facilitated as E-ex increases. However, EMIs completely ceased below a characteristic temperature T-ces = 170 K even for the maximum vertical bar E-ex vertical bar = 5 kV/cm applied in this work. A direct comparison of the magnetization data of the Co/PMN-xPT/Co hybrids reported here with the electromechanical properties of the parent PMN-xPT crystals plausibly indicates that EMIs are motivated by the coupling of the ferromagnetic domains of the Co outer layers with the ferroelectric domains of the PMN-xPT crystal. These results highlight the drawback of EMIs in relevant hybrids and delimit the temperature regime for the reliable operation of the Co/PMN-xPT/Co ones studied here. (c) 2014 AIP Publishing LLC.
Kambas A, Venetsanou F. The Democritos Movement Screening Tool for preschool children (DEMOST-PRE< sup>©): Development and factorial validity. Research in developmental disabilities. 2014;35(7):1528-1533.
Anastasopoulos MP, Tzanakaki A, Simeonidou D. Dependable multi-tenant infrastructures supporting cloud and mobile cloud services. In: ; 2014. pp. 1511 - 1516. Website
Anastasopoulos MP, Tzanakaki A, Simeonidou D. Dependable multi-tenant infrastructures supporting cloud and mobile cloud services. In: 2014 IEEE Globecom Workshops, GC Wkshps 2014. ; 2014. pp. 1511-1516. Website
Dumbrajs O, Avramidis KA, Franck J, Jelonnek J. On the dependence of the efficiency of a 240 GHz high-power gyrotron on the displacement of the electron beam and on the azimuthal index. Physics of Plasmas [Internet]. 2014;21. Website
Zegaer BH, Ioannidis A, Babis GC, Ioannidou V, Kossyvakis A, Bersimis S, Papaparaskevas J, Petinaki E, Pliatsika P, Chatzipanagiotou S. Detection of Bacteria Bearing Resistant Biofilm Forms, by Using the Universal and Specific PCR is Still Unhelpful in the Diagnosis of Periprosthetic Joint Infections. Front Med (Lausanne). 2014;1:30.Abstract
Intraoperative conventional bacteriological cultures were compared with different polymerase chain reaction (PCR) methods in patients with total joint arthroplasties. The isolated bacteria were investigated for biofilm formation, and the biofilm forming strains, in their planktonic and biofilm forms, were further tested for their antimicrobial resistance against several clinically important antimicrobials. Forty four bone and joint samples were included and classified as infected or non-infected according to standard criteria for periprosthetic hip and knee infections. For the bacteriological diagnosis, conventional culture, two types of universal PCR and species specific PCR for three selected pathogens (Staphylococcus aureus, Staphylococcus epidermidis, and Pseudomonas aeruginosa) were applied. Biofilm formation determination was performed by the tissue culture plate method. Antimicrobial susceptibility of the planktonic bacteria was performed by the minimal inhibitory concentration determination and, of the biofilm forms, by the minimal inhibitory concentration for bacterial regrowth from the biofilm. Twenty samples were culture positive, with S. epidermidis, S. aureus, or P. aeruginosa. All PCR methods were very ineffective in detecting only one pathogen. All isolates were biofilm positive and their biofilm forms, were highly resistant. In this study, compared to PCR, culture remains the "gold standard." The biofilm formation by the causative bacteria and the concomitant manifold increased antimicrobial resistance may explain the clinical failure of treatment in some cases and should be considered in the future for therapeutic planning.
Stamopoulos D, Zeibekis M, Manios E, Boukos N, Niarchos D. Deterioration of exchange bias in CoO-Co bilayers by the roughness of the ZnO substrates Niarchos D, Hadjipanayis G, Kalogirou O. JEMS 2013 - JOINT EUROPEAN MAGNETIC SYMPOSIA. 2014;75(7th Joint European Magnetic Symposia (JEMS).Abstract
The Exchange Bias (EB) effect is observed at the interface of Antiferromagnet/Ferromagnet (AF/FM) structures and depends on the interface roughness (IR). Until today, only low IR values, usually below 10 nm, have been investigated. Here we investigate an extended range of IR through controlling the surface roughness (SR) of the employed substrates. We employ CoO/Co bilayers (thickness within 10-60 nm), a classic AF/FM structure that exhibits intense EB. ZnO was employed as the substrate in both film and bulk forms, enabling us to vary the SR up to 840 nm. Our data reveal a strong relative decrease, ranging within 20-65%, of both the shift H-shift(EB) and coercive H-c(EB) fields upon increase of SR (IR), for both parallel and normal magnetic field-sample configurations. For the explanation of these findings we propose that in thin AF/FM structures deposited on rough substrates the local magnetization, M-f of the FM is 'locked' mainly in-layer due to shape anisotropy, thus it is forced to follow the morphologically rough landscape of the substrate. This imposes misalignment between M-f, that is 'directionally random', and H-ex, that is 'directionally oriented'. This weakens the biasing potential of H-ex on M-f and reduces the relative macroscopic parameters H-shift(EB) and HcEB
Moukas AI, Thomaidis NS, Calokerinos AC. Determination of polychlorinated biphenyls by liquid chromatography-atmospheric pressure photoionization-mass spectrometry. Journal of Mass Spectrometry [Internet]. 2014;49:1096-1107. Website
Karakassi K, Lindinger S, Mark M. Deutsche Romantik: Transformationen Und Transgressionen. Peter Lang Pub Inc; 2014 pp. p.
Kaitelidou D, Lemonidou C, Galanis P, Sourtzi P, Zikos D, Siskou O, Elefsiniotis I, Em V, Theodorou M. Developing a Tool to Increase Access of Vulnerable groups to Health Care: An Initiative to Mitigate the Barriers. conference presentation, 5th EUPHA European Conference on Migrant and Ethnic Minority Health. 2014:10-12.
Kaitelidou D, Lemonidou C, Galanis P, Sourtzi P, Zikos D, Siskou O, Elefsiniotis I, Em V, Theodorou M. Developing a Tool to Increase Access of Vulnerable groups to Health Care: An Initiative to Mitigate the Barriers. In: conference presentation, 5th EUPHA European Conference on Migrant and Ethnic Minority Health. ; 2014. pp. 10–12.
Korologou M, Flocas H, Michalopoulou H. Developing an index for heavy convective rainfall forecasting over a Mediterranean coastal area. Natural Hazards and Earth System Sciences [Internet]. 2014;14:2205-2214. Website
Developing the ability to refuse: a cross-sectional study of Greek FL refusals
Bella S. Developing the ability to refuse: a cross-sectional study of Greek FL refusals. Journal of Pragmatics [Internet]. 2014;61:35-62. Publisher's Version
Jelonnek J, Avramidis K, Franck J, Gantenbein G, Hesch K, Jin J, Kalaria P, Malygin A, Pagonakis IG, Rzesnicki T, et al. Development of advanced gyrotrons. In: International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz. ; 2014. Website
Drakopoulos S, Katselidis I. The development of trade union theory and mainstream economic methodology. Journal of Economic Issues. 2014;48:1133–1149.
Karakassi K. Die Leiden des jungen Leandros: Notizen zur politischen Romantik. In: Mike M, Tsirimokou L, Naoum I, Tiktopoulou K Neugriechische Literatur und Kritik seit der Aufklärung und bis heute. Athen: Sokolis -Kouledaki; 2014. pp. 177–188.
Gardener SL, Rainey-Smith SR, Barnes MB, Sohrabi HR, Weinborn M, Lim YY, Harrington K, Taddei K, Gu Y, Rembach A, et al. Dietary patterns and cognitive decline in an Australian study of ageing. Mol Psychiatry. 2014.Abstract
The aim of this paper was to investigate the association of three well-recognised dietary patterns with cognitive change over a 3-year period. Five hundred and twenty-seven healthy participants from the Australian Imaging, Biomarkers and Lifestyle study of ageing completed the Cancer Council of Victoria food frequency questionnaire at baseline and underwent a comprehensive neuropsychological assessment at baseline, 18 and 36 months follow-up. Individual neuropsychological test scores were used to construct composite scores for six cognitive domains and a global cognitive score. Based on self-reported consumption, scores for three dietary patterns, (1) Australian-style Mediterranean diet (AusMeDi), (2) western diet and (3) prudent diet were generated for each individual. Linear mixed model analyses were conducted to examine the relationship between diet scores and cognitive change in each cognitive domain and for the global score. Higher baseline adherence to the AusMeDi was associated with better performance in the executive function cognitive domain after 36 months in apolipoprotein E (APOE) ɛ4 allele carriers (P<0.01). Higher baseline western diet adherence was associated with greater cognitive decline after 36 months in the visuospatial cognitive domain in APOE ɛ4 allele non-carriers (P<0.01). All other results were not significant. Our findings in this well-characterised Australian cohort indicate that adherence to a healthy diet is important to reduce risk for cognitive decline, with the converse being true for the western diet. Executive function and visuospatial functioning appear to be particularly susceptible to the influence of diet.Molecular Psychiatry advance online publication, 29 July 2014; doi:10.1038/mp.2014.79.
Zachariadou L, Stathi A, Tassios PT, Pangalis A, Legakis NJ, Papaparaskevas J. Differences in the epidemiology between paediatric and adult invasive Streptococcus pyogenes infections. Epidemiol Infect. 2014;142(3):512-9.Abstract
In order to investigate for possible differences between paediatric and adult invasive Streptococcus pyogenes (iGAS) infections, a total of 142 cases were identified in 17 Greek hospitals during 2003-2007, of which 96 were children and 46 adults. Bacteraemia, soft tissue infections, streptococcal toxic shock syndrome (STSS), and necrotizing fasciitis were the main clinical presentations (67·6%, 45·1%, 13·4%, and 12·0% of cases, respectively). Bacteraemia and lymphadenitis were significantly more frequent in children (P=0·019 and 0·021, respectively), whereas STSS was more frequent in adults (P=0·017). The main predisposing factors in children were varicella and streptococcal pharyngotonsillitis (25% and 19·8%, respectively), as opposed to malignancy, intravenous drug abuse and diabetes mellitus in adults (19·6%, 15·2% and 10·9%, respectively). Of the two dominant emm-types, 1 and 12 (28·2% and 8·5%, respectively), the proportion of emm-type 12 remained stable during the study period, whereas emm-type 1 rates fluctuated considerably. Strains of emm-type 1 from children were associated with erythromycin susceptibility, STSS and intensive-care-unit admission, whereas emm-type 12 isolates from adults were associated with erythromycin and clindamycin resistance. Finally, specific emm-types were detected exclusively in adults or in children. In conclusion, several clinical and epidemiological differences were detected, that could prove useful in designing age-focused strategies for prevention and treatment of iGAS infections.
Petrović, J. PGĆBPLZSMJA. Different extraction methodologies and their influence on the bioactivity of the wild edible mushroom Laetiporus sulphureus (Bull.) Murrill. Food and Function [Internet]. 2014;5:2948-2960. Website
Petrović J, Papandreou M, Glamočlija J, Ćirić A, Baskakis C, Proestos C, Lamari F, Zoumpoulakis P, Soković M. Different extraction methodologies and their influence on the bioactivity of the wild edible mushroom Laetiporus sulphureus (Bull.) Murrill. [Internet]. 2014;5:2948-2960. Website
Petrović J, Papandreou M, Glamočlija J, Ćirić A, Baskakis C, Proestos C, Lamari F, Zoumpoulakis P, Soković M. Different extraction methodologies and their influence on the bioactivity of the wild edible mushroom Laetiporus sulphureus (Bull.) Murrill. Food and Function [Internet]. 2014;5:2948-2960. Website
Aad G, others. {The differential production cross section of the $\phi $ (1020) meson in $\sqrt{s}$ = 7 TeV $pp$ collisions measured with the ATLAS detector}. Eur. Phys. J. C. 2014;74:2895.
Digital enrichment of EFL textbooks
Mitsikopoulou B. Digital enrichment of EFL textbooks. In: Psaltou Joycey A, Agathopoulou E, Mattheoudakis M Cross-curricular approaches to language education. Newcastle: Cambridge Scholars Publishing; 2014. pp. 404-430. 2014_gala_mitsikopoulou.pdf
Tsokos Α, Kotsi Ε, Vassilakis E. Digital processing of high spatial resolution remote sensing data time series in order to observe the temporal displacement of shorelines. In: 6th Panhellenic Conference on Coastal Zone Management and Improvement. Athens; 2014. pdf
Salvilla SA, Dubois AEJ, Flokstra-de Blok BMJ, Panesar SS, Worth A, Patel S, Muraro A, Halken S, Hoffmann-Sommergruber K, DunnGalvin A, et al. Disease-specific health-related quality of life instruments for IgE-mediated food allergy. Allergy. 2014;69(7):834-44.Abstract
This is one of seven interlinked systematic reviews undertaken on behalf of the European Academy of Allergy and Clinical Immunology as part of their Guidelines for Food Allergy and Anaphylaxis, which focuses on instruments developed for IgE-mediated food allergy. Disease-specific questionnaires are significantly more sensitive than generic ones in measuring the response to interventions or future treatments, as well as estimating the general burden of food allergy. The aim of this systematic review was therefore to identify which disease-specific, validated instruments can be employed to enable assessment of the impact of, and investigations and interventions for, IgE-mediated food allergy on health-related quality of life (HRQL). Using a sensitive search strategy, we searched seven electronic bibliographic databases to identify disease-specific quality of life (QOL) tools relating to IgE-mediated food allergy. From the 17 eligible studies, we identified seven disease-specific HRQL instruments, which were then subjected to detailed quality appraisal. This revealed that these instruments have undergone formal development and validation processes, and have robust psychometric properties, and therefore provide a robust means of establishing the impact of food allergy on QOL. Suitable instruments are now available for use in children, adolescents, parents/caregivers, and adults. Further work must continue to develop a clinical minimal important difference for food allergy and for making these instruments available in a wider range of European languages.
Kokkinos C, Economou A. Disposable microfabricated 3-electrode electrochemical devices with integrated antimony working electrode for stripping voltammetric determination of selected trace metals. Sensors and Actuators B: ChemicalSensors and Actuators B: Chemical. 2014;192:572-577.
Roulia M, Mavromoustakos T, Vassiliadis AA, Mali G. Distinctive spectral and microscopic features for characterizing the three-dimensional local aluminosilicate structure of perlites. Journal of Physical Chemistry C [Internet]. 2014;118(46):26649 - 26658. Website
Demetriou IC, Vassiliou EE. On distributed-lag modelling algorithms by $r$-convexity and piecewise monotonicity. On the occasion of the 60th birthday of Panayote Pardalos. In: Optimization in Science and Engineering. Th. M. Rassias, C. A. Floudas and S. Butenko, Editors. Springer-Verlag; 2014. pp. 115-140.
Pavlakis EP. ¿Divertir o enseñar? la recepción de la realidad cultural helénica en la Edad de oro de José Martí. In: Pavlakis EP, Drosos D, Papageorgiou A Estudios y Homenajes Hispanoamericanos . Vol. II. Madrid: Ediciones del Orto ; 2014. pp. 205-210.
Konstantinou EA, Birbas K, Katsoulas TA, Karampinis DF, Mariolis-Sapsakos TD, Kaklamanos I, Bonatsos G. Do we need navigation systems in the vascular access practice? A case of peripherally inserted central catheter malposition. J Vasc Access. 2014;15(6):541-2.
Karavasilis V, Kosmidis P, Syrigos KN, Mavropoulou P, Dimopoulos MA, Kotoula V, Pectasides D, Boukovinas I, Klouvas G, Kalogera-Fountzila A, et al. Docetaxel and intermittent erlotinib in patients with metastatic non-small cell lung cancer; a phase II study from the hellenic cooperative oncology group. Anticancer Research [Internet]. 2014;34(10):5649 - 5655. WebsiteAbstract
Aim: To determine the more effective dosing sequence of intermittent erlotinib and docetaxel for treating chemotherapy-naive patients with advanced Non-Small Cell Lung Cancer (NSCLC). Patients and Methods: Patients were randomized to receive daily erlotinib for 12 consecutive days prior to docetaxel (Arm A) or after docetaxel (Arm B). Progression-free survival (PFS) was the primary end-point; secondary end-points were overall survival (OS) and objective response rate (ORR). Results: Fifty eligible patients received a total of 226 treatment cycles (median: 3). Median PFS and OS were 3.6 months and 10.5 months, respectively (differences were not statistically significant between the two arms). Neutropenia grade 3 and 4 occurred in 15 patients, while two patients developed grade 3 diarrhea. There were two treatment-related deaths (pulmonary embolism and non-neutropenic sepsis). Conclusion: Intermittent administration of erlotinib does not appear to improve the clinical outcome of single-agent docetaxel chemotherapy in unselected patients with NSCLC in the first-line setting. © 2014, International Institute of Anticancer Research. All rights reserved.
Arealis G, Galanopoulos I, Nikolaou VS, Lacon A, Ashwood N, Kitsis C. Does the CT improve inter- and intra-observer agreement for the AO, Fernandez and Universal classification systems for distal radius fractures?. Injury. 2014;45(10):1579-84.Abstract
INTRODUCTION: Distal radius fractures are very common upper limb injuries irrespective of the patient's age. The aim of our study is to evaluate the reliability of the three systems that are often used for their classification (AO - Arbeitsgemeinschaft für Osteosynthesefragen/Association for the Study of Internal Fixation, Fernandez and Universal) and to assess the need for computed tomography (CT) scan to improve inter- and intra-observer agreement. MATERIALS AND METHODS: Five orthopaedic surgeons and two hand surgeons classified radiographs and CT scans of 26 patients using the Fernandez, AO and Universal systems. All data were recorded using MS Excel and Kappa statistics were performed to determine inter- and intra-observer agreement and to evaluate the role of CT scan. RESULTS: Fair-to-moderate inter-observer agreement was noted with the use of X-rays for all classification systems. Intra-observer reproducibility did not improve with the addition of CT scans, especially for the senior hand surgeons. CONCLUSIONS: The agreement rates observed in the present study show that currently there is no classification system that is fully reproducible. Adequate experience is required for the assessment and treatment of these injuries. CT scan should be requested only by experienced hand surgeons in order to help guide treatment, as it does not significantly improve inter- and intra-observer agreement for all classification systems.
Fountzilas G, Dafni U, Papadimitriou C, Timotheadou E, Gogas H, Eleftheraki AG, Xanthakis I, Christodoulou C, Koutras A, Papandreou CN, et al. Dose-dense sequential adjuvant chemotherapy followed, as indicated, by trastuzumab for one year in patients with early breast cancer: First report at 5-year median follow-up of a Hellenic Cooperative Oncology Group randomized phase III trial. BMC Cancer [Internet]. 2014;14(1). WebsiteAbstract
Background: Dose-dense sequential chemotherapy including anthracyclines and taxanes has been established in the adjuvant setting of high-risk operable breast cancer. However, the preferable taxane and optimal schedule of administration in a dose-dense regimen have not been defined yet.Methods: From July 2005 to November 2008, 1001 patients (990 eligible) were randomized to receive, every 2 weeks, 3 cycles of epirubicin 110 mg/m2 followed by 3 cycles of paclitaxel 200 mg/m2 followed by 3 cycles of intensified CMF (Arm A; 333 patients), or 3 cycles of epirubicin followed by 3 cycles of CMF, as in Arm A, followed 3 weeks later by 9 weekly cycles of docetaxel 35 mg/m2 (Arm B; 331), or 9 weekly cycles of paclitaxel 80 mg/m2 (Arm C; 326). Trastuzumab was administered for one year to HER2-positive patients post-radiation.Results: At a median follow-up of 60.5 months, the 3-year disease-free survival (DFS) rate was 86%, 90% and 88%, for Arms A, B and C, respectively, while the 3-year overall survival (OS) rate was 96% in all arms. No differences were found in DFS or OS between the combined B and C Arms versus Arm A (DFS: HR = 0.81, 95% CI: 0.59-1.11, P = 0.20; OS: HR = 0.84, 95% CI: 0.55-1.30, P = 0.43). Among the 255 patients who received trastuzumab, 189 patients (74%) completed 1 year of treatment uneventfully. In all arms, the most frequently reported severe adverse events were neutropenia (30% vs. 27% vs. 26%) and leucopenia (12% vs. 13% vs. 12%), while febrile neutropenia occurred in fifty-one patients (6% vs. 4% vs. 5%). Patients in Arm A experienced more often severe pain (P = 0.002), neurological complications (P = 0.004) and allergic reactions (P = 0.004), while patients in Arm B suffered more often from severe skin reactions (P = 0.020).Conclusions: No significant differences in survival between the regimens were found in the present phase III trial. Taxane scheduling influenced the type of severe toxicities. HER2-positive patients demonstrated comparable 3-year DFS and OS rates with those reported in other similar studies.Trial registration: Australian New Zealand Clinical Trials Registry ACTRN12610000151033. © 2014 Fountzilas et al.; licensee BioMed Central Ltd.
Papaioannou S. Duplication and the Politics of Comic De-structure; or Why There Not Need Be Two Slaves, While There Are Two Cooks in the Aulularia. In: Plautine Trends. Plot, Language and Reception (Trends in Classics Supplementary Volumes). Edited by E. Karakassis and I. Perysiniakis. Berlin: De Gruyter; 2014. pp. 63-92. Publisher's Version
van der Geer, A.A.E., Lyras, G.A., VAN DEN HOEK OSTENDE, L.W., DE VOS, J., DRINIA H. A dwarf elephant and a rock mouse on Naxos (Cyclades, Greece) with a revision of the palaeozoogeography of the Cycladic Islands (Greece) during the Pleistocene in relation to adjacent areas. Palaeogeography, Palaeoclimatology, Palaeoecology [Internet]. 2014;404:133-144. Publisher's Version
Katavoutas G a, Flocas HA a, Matzarakis A b. Dynamic modeling of human thermal comfort after the transition from an indoor to an outdoor hot environment. International Journal of Biometeorology [Internet]. 2014. WebsiteAbstract
Thermal comfort under non-steady-state conditions primarily deals with rapid environmental transients and significant alterations of the meteorological conditions, activity, or clothing pattern within the time scale of some minutes. In such cases, thermal history plays an important role in respect to time, and thus, a dynamic approach is appropriate. The present study aims to investigate the dynamic thermal adaptation process of a human individual, after his transition from a typical indoor climate to an outdoor hot environment. Three scenarios of thermal transients have been considered for a range of hot outdoor environmental conditions, employing the dynamic two-node IMEM model. The differences among them concern the radiation field, the activity level, and the body position. The temporal pattern of body temperatures as well as the range of skin wettedness and of water loss have been investigated and compared among the scenarios and the environmental conditions considered. The structure and the temporal course of human energy fluxes as well as the identification of the contribution of body temperatures to energy fluxes have also been studied and compared. In general, the simulation results indicate that the response of a person, coming from the same neutral indoor climate, varies depending on the scenario followed by the individual while being outdoors. The combination of radiation field (shade or not) with the kind of activity (sitting or walking) and the outdoor conditions differentiates significantly the thermal state of the human body. Therefore, 75 % of the skin wettedness values do not exceed the thermal comfort limit at rest for a sitting individual under the shade. This percentage decreases dramatically, less than 25 %, under direct solar radiation and exceeds 75 % for a walking person under direct solar radiation. © 2014 ISB.
Katavoutas G, Flocas HA, Matzarakis A. Dynamic modeling of human thermal comfort after the transition from an indoor to an outdoor hot environment. International Journal of Biometeorology [Internet]. 2014;59:205-216. Website
Syriopoulos T, Roumpis E. Dynamics and risk factors in hedge funds returns: implications for portfolio construction and performance evaluation. The Journal of Economic Asymmetries. 2014;11:58-77.
Muraro A, Werfel T, Hoffmann-Sommergruber K, Roberts G, Beyer K, Bindslev-Jensen C, Cardona V, Dubois A, duToit G, Eigenmann P, et al. EAACI food allergy and anaphylaxis guidelines: diagnosis and management of food allergy. Allergy. 2014;69(8):1008-25.Abstract
Food allergy can result in considerable morbidity, impact negatively on quality of life, and prove costly in terms of medical care. These guidelines have been prepared by the European Academy of Allergy and Clinical Immunology's (EAACI) Guidelines for Food Allergy and Anaphylaxis Group, building on previous EAACI position papers on adverse reaction to foods and three recent systematic reviews on the epidemiology, diagnosis, and management of food allergy, and provide evidence-based recommendations for the diagnosis and management of food allergy. While the primary audience is allergists, this document is relevant for all other healthcare professionals, including primary care physicians, and pediatric and adult specialists, dieticians, pharmacists and paramedics. Our current understanding of the manifestations of food allergy, the role of diagnostic tests, and the effective management of patients of all ages with food allergy is presented. The acute management of non-life-threatening reactions is covered in these guidelines, but for guidance on the emergency management of anaphylaxis, readers are referred to the related EAACI Anaphylaxis Guidelines.
Muraro A, Halken S, Arshad SH, Beyer K, Dubois AEJ, duToit G, Eigenmann PA, Grimshaw KEC, Hoest A, Lack G, et al. EAACI food allergy and anaphylaxis guidelines. Primary prevention of food allergy. Allergy. 2014;69(5):590-601.Abstract
Food allergy can have significant effects on morbidity and quality of life and can be costly in terms of medical visits and treatments. There is therefore considerable interest in generating efficient approaches that may reduce the risk of developing food allergy. This guideline has been prepared by the European Academy of Allergy and Clinical Immunology's (EAACI) Taskforce on Prevention and is part of the EAACI Guidelines for Food Allergy and Anaphylaxis. It aims to provide evidence-based recommendations for primary prevention of food allergy. A wide range of antenatal, perinatal, neonatal, and childhood strategies were identified and their effectiveness assessed and synthesized in a systematic review. Based on this evidence, families can be provided with evidence-based advice about preventing food allergy, particularly for infants at high risk for development of allergic disease. The advice for all mothers includes a normal diet without restrictions during pregnancy and lactation. For all infants, exclusive breastfeeding is recommended for at least first 4-6 months of life. If breastfeeding is insufficient or not possible, infants at high-risk can be recommended a hypoallergenic formula with a documented preventive effect for the first 4 months. There is no need to avoid introducing complementary foods beyond 4 months, and currently, the evidence does not justify recommendations about either withholding or encouraging exposure to potentially allergenic foods after 4 months once weaning has commenced, irrespective of atopic heredity. There is no evidence to support the use of prebiotics or probiotics for food allergy prevention.
Muraro A, Hoffmann-Sommergruber K, Holzhauser T, Poulsen LK, Gowland MH, Akdis CA, Mills ENC, Papadopoulos N, Roberts G, Schnadt S, et al. EAACI Food Allergy and Anaphylaxis Guidelines. Protecting consumers with food allergies: understanding food consumption, meeting regulations and identifying unmet needs. Allergy. 2014;69(11):1464-72.Abstract
Individuals suffering from IgE-mediated food allergy usually have to practise life-long food allergen avoidance. This document aims to provide an overview of recent evidence-based recommendations for allergen risk assessment and management in the food industry and discusses unmet needs and expectations of the food allergic consumer in that context. There is a general duty of care on the food industry and obligations in European Union legislation to reduce and manage the presence of allergens alongside other food hazards. Current evidence enables quantification of allergen reference doses used to set-up reliable food safety management plans for some foods. However, further work is required to include a wider variety of foods and to understand the impact of the food matrix as well as additional factors which affect the progression and severity of symptoms as a function of dose. Major concerns have been raised by patients, carers and patient groups about the use of precautionary 'may contain' labelling to address the issue of unintended presence of allergens; these therefore need to be reconsidered. New and improved allergen detection methods should be evaluated for their application in food production. There is an urgent requirement for effective communication between healthcare professionals, patient organizations, food industry representatives and regulators to develop a better approach to protecting consumers with food allergies.
Giannakopoulos G, Agapidaki E, Dimitrakaki C, Oikonomidou D, Petanidou D, Tsermidou L, Kolaitis G, Tountas Y, Papadopoulou K. Early childhood educators’ perceptions of preschoolers' mental health problems: a qualitative analysis. [Internet]. 2014;13(1):1. WebsiteAbstract
Early childhood education services create potentially optimal opportunities to identify and respond effectively to preschoolers' mental health problems. However, little is known about the knowledge, skills and competencies of early childhood educators in the area of mental health. The present study aimed to contribute to this field through conducting focus group interviews with professionals from public early childhood education centres in Greece.
CORNÉE, J.-J., MÜNCH, PH., Melinte-Dobrinescu, M., Ben Moussa, A., Quillévéré, F., Drinia, H., Azdimousa, A., TOUHAMI, A.O., Merzeraud, G., Fauquette, S., et al. The early Pliocene reflooding in the Western Mediterranean: new insights from the rias of the Internal Rif, Morocco. CR Geoscience [Internet]. 2014;346: 90-98. Publisher's Version
Kamberidou I. The East in the Eyes of Western Women travellers of the 18th and 19th centuries: solidarity and understanding the East. Proceedings of The East in The Eyes of The West International Conference of the Faculty of Arts, Kuwait University. 2014. themesconditions_of_the_conference-2013.pdf the_east_in_the_eyes_of_the_west._faculty_of_arts._kuwait_university_2013.pdf
Kikilias N, Siskou O, Kaitelidou D, Galanis P, Tsoulos N, Vafeiadis J, Liaropoulos L. Economic consequences of the adaption of the 21 gene reverse transcriptase-polymerase chain reaction RT-PCR assay from the Greek third payer perspective. Value in Health. 2014;17:A630–A631.
Kikilias N, Siskou O, Kaitelidou D, Galanis P, Tsoulos N, Vafeiadis J, Liaropoulos L. Economic consequences of the adaption of the 21 gene reverse transcriptase-polymerase chain reaction RT-PCR assay from the Greek third payer perspective. Value in Health. 2014;17(7):A630-A631.
Wu J, Wosinska L, Mas Machuca C, Tzanakaki A, Hasegawa H. Editorial. Optical Switching and Networking [Internet]. 2014;11:53-54. Website
Venetsanou F, Donti O, Koutsouba M. The effect of a music/ movement program on preschooler’s motor rhythmic ability. European Psychomotricity Journal. 2014;6(1):60-73.
Georgantzinos SK, Giannopoulos GI, Anifantis NK. The effect of atom vacancy defect on the vibrational behavior of single-walled carbon nanotubes: a structural mechanics approach. Advances in Mechanical Engineering. 2014;6:291645.
Tsimaris P, Deligeoroglou E, Athanasopoulos N, Economou E, Stamatelopoulos K, Rizos D, Papamichael C, Lambrinoudaki I, Mastorakos G, Creatsas G. The effect of hormone therapy on biochemical and ultrasound parameters associated with atherosclerosis in 46,XY DSD individuals with female phenotype. Gynecological Endocrinology. 2014;30(10):721 - 725.Abstract
© 2014 Informa UK Ltd. All rights reserved. The aim of this study was to evaluate the effect of hormone therapy (HT) in the endothelial function of 46,XY disorders of sexual development (DSD) patients with female phenotype. Biochemical and ultrasound measurements were performed in 20 patients at initiation of oral 2mg 17β-estradiol/1mg norethisterone acetate, and after 6 months of therapy. Lipid profile, including total cholesterol (TC), LDL, HDL, triglycerides (TG) and Atherogenic Index of Plasma (AIP), as well as levels of VE-Cadherin, E-Selectin, Thrombomodulin and vWf were determined. Ultrasonographic examinations included evaluation of flow-mediated dilatation (FMD) and measurement of Carotid and Femoral Intima Media Thickness (IMT). HT raised HDL (35.4mg/dl versus 40.1mg/dl, p=0.019) while lowering TG (166mg/dl versus 109mg/dl, p=0.026) and AIP (0.24 versus 0.04, p=0.007). No changes were noted in TC and LDL (215.7mg/dl versus 192.25mg/dl and 87.46mg/dl versus 76.35mg/dl, respectively). There was significant reduction of VE-Cadherin (4.05ng/ml versus 2.20ng/ml, p=0.002) and E-selectin (73.98ng/ml versus 56.73ng/ml, p=0.004). No change was observed in Thrombomodulin and vWf (11.76ng/ml versus 13.90ng/ml and 80.75% versus 79.55%, respectively). FMD improved significantly (5.4% versus 8.15%, p=0.003), while only carotid bulb IMT decreased significantly (0.65mm versus 0.60mm, p=0.018). Overall, HT was found to improve biochemical and ultrasound markers of endothelial function in 46,XY DSD patients with female phenotype.
Douvali M, Chatziralli IP, Theodossiadis PG, Chatzistefanou KI, Giannakaki E, Rouvas AA. Effect of macular ischemia on intravitreal ranibizumab treatment for diabetic macular edema. Ophthalmologica. 2014;232:136–143.
Koumarianou A, Christodoulou M-I, Patapis P, Papadopoulos I, Liakata E, Giagini A, Stavropoulou A, Poulakaki N, Tountas N, Xiros N, et al. The effect of metronomic versus standard chemotherapy on the regulatory to effector T-cell equilibrium in cancer patients. Experimental hematology & oncology. 2014;3:1–10.
Koumarianou A, Christodoulou M-I, Patapis P, Papadopoulos I, Liakata E, Giagini A, Stavropoulou A, Poulakaki N, Tountas N, Xiros N, et al. The effect of metronomic versus standard chemotherapy on the regulatory to effector T-cell equilibrium in cancer patients. Experimental Hematology and Oncology [Internet]. 2014;3. Website
Koumarianou A, Christodoulou M-I, Patapis P, Papadopoulos I, Liakata E, Giagini A, Stavropoulou A, Poulakaki N, Tountas N, Xiros N, et al. The effect of metronomic versus standard chemotherapy on the regulatory to effector T-cell equilibrium in cancer patients. Experimental Hematology and Oncology. 2014;3.
Yu A, Giannone T, Scheffler P, Doonan RJ, Egiziano G, Gomez Y-H, Papaioannou TG, Daskalopoulou SS. The effect of oral Contraceptive pills and the natural menstrual cYCLe on arterial stiffness and hemodynamICs (CYCLIC). Journal of Hypertension [Internet]. 2014;32(1):100 - 107. Website
Yu A, Giannone T, Scheffler P, Doonan RJ, Egiziano G, Gomez Y-H, Papaioannou TG, Daskalopoulou SS. The effect of oral Contraceptive pills and the natural menstrual cYCLe on arterial stiffness and hemodynamICs (CYCLIC). Journal of Hypertension [Internet]. 2014;32(1):100 - 107. Website
Han C, Andersen J, Likodimos V, Falaras P, Linkugel J, Dionysiou DD. The effect of solvent in the sol-gel synthesis of visible light-activated, sulfur-doped TiO2 nanostructured porous films for water treatment. Catalysis Today [Internet]. 2014;224:132-139. WebsiteAbstract
The effects of solvent on the synthesis of visible light-activated, sulfur-doped TiO2 (S-TiO2) films were studied. Four different polar, protic solvents, isopropanol, 1-butanol, ethanol, and methanol (iPrOH, BtOH, EtOH, and MeOH), were chosen as the solvent in four titania sol-gel preparations. The films were characterized by X-ray diffraction (XRD), high resolution transmission electron microscopy (HR-TEM), atomic force microscopy (AFM), environmental scanning electron microscopy (ESEM), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FT-IR), Ultraviolet (UV)-vis diffuse reflectance, and porosimetry. The structural, morphological, and porous characteristics of the sulfur-doped TiO2 films were correlated with solvent physical properties such as the dielectric constant (D-value) and the saturated vapor pressure. According to XPS and FT-IR, S6+/S4+ cations replaced Ti4+ ions in the lattice of TiO2, resulting in the formation of localized states within the bandgap of TiO2. The optical absorption edge for all S-TiO2 films was significantly shifted toward the visible light region. The solvent D-value has a negligible effect on the bandgap energy change and the doping states of the prepared S-TiO2 samples. S-TiO 2 films synthesized using MeOH (S-TiO2-MeOH), despite their lower Brunauer, Emmett, and Teller (BET) surface area and porosity compared to the other films, showed the highest photocatalytic activity for the degradation of the hepatotoxin microcystin-LR (MC-LR) under visible light irradiation due to their high surface roughness and large pore size. The tailor-designed structure of the S-TiO2-MeOH film contributed to the high photocatalytic degradation rates of MC-LR. The larger pore size of the S-TiO2-MeOH films allowed easier transport of MC-LR inside the porous film, while the higher film surface roughness could increase nano-interfacial interactions between MC-LR and surface active sites. These results indicate that the structural and morphological properties of S-TiO2 photocatalysts can be tailor-designed using different solvents in the sol-gel synthesis, while inducing negligible effects on the sulfur doping and the visible light activation of TiO2. Therefore, the enhancement of photocatalytic activity of S-TiO2 films can be achieved by judicious choice of the main solvent for the sol-gel method. © 2013 Elsevier B.V.
Vrachatis D, Papaioannou TG, Konstantopoulou A, Nasothimiou EG, Millasseau S, Blacher J, Safar ME, Sfikakis PP, Stergiou GS, Protogerou AD. Effect of supine versus sitting position on noninvasive assessment of aortic pressure waveform: A randomized cross-over study. Journal of Human Hypertension [Internet]. 2014;28(4):236 - 241. Website
Vrachatis D, Papaioannou TG, Konstantopoulou A, Nasothimiou EG, Millasseau S, Blacher J, Safar ME, Sfikakis PP, Stergiou GS, Protogerou AD. Effect of supine versus sitting position on noninvasive assessment of aortic pressure waveform: A randomized cross-over study. Journal of Human Hypertension [Internet]. 2014;28(4):236 - 241. Website
Barbero G, Lelidis I. Effective dielectric constant of electrolytes. Journal of Applied Physics [Internet]. 2014;115:194101. Publisher's Version
Stavropoulou S, Georgaki A, Moschos F. The Effectiveness of visual feedback singing vocal technology in Greek Elementary School. In: ICMC. ; 2014.
Zelenitsas C a, Kalapotharakos V b, Mitrotasios M a, Bogdanis G a, Tokmakidis S b. The effects of a concurrent strength and endurance training on endurance and muscle strength in soccer players. Cultura, Ciencia y Deporte [Internet]. 2014;9:S78. Website
Zelenitsas, C.a KMBTV b M a. The effects of a concurrent strength and endurance training on endurance and muscle strength in soccer players. Cultura, Ciencia y Deporte [Internet]. 2014;9:S78. Website
Raftogianni A, Stamatakis A, Diamantopoulou A, Kollia A-M, Stylianopoulou F. Effects of an early experience of reward through maternal contact or its denial on the dopaminergic system of the rat brain. Neuroscience. 2014;269:11-20.
Raftogianni A, Stamatakis A, Diamantopoulou A, Kollia A-M, Stylianopoulou F. Effects of an early experience of reward through maternal contact or its denial on the dopaminergic system of the rat brain. Neuroscience [Internet]. 2014;269:11-20. Website
Raftogianni A, Stamatakis A, Diamantopoulou A, Kollia A-M, Stylianopoulou F. Effects of an early experience of reward through maternal contact or its denial on the dopaminergic system of the rat brain. Neuroscience [Internet]. 2014;269:11-20. Website
Donti, O. TBCGC. Effects of baseline levels of flexibility and vertical jump ability on performance following different volumes of static stretching and potentiating exercises in elite gymnasts. Journal of Sports Science and Medicine [Internet]. 2014;13:105-113. WebsiteAbstract
This study examined the effects of baseline flexibility and vertical jump ability on straight leg raise range of motion (ROM) and counter-movement jump performance (CMJ) following different volumes of stretching and potentiating exercises. ROM and CMJ were measured after two different warm-up protocols involving static stretching and potentiating exercises. Three groups of elite athletes (10 male, 14 female artistic gymnasts and 10 female rhythmic gymnasts) varying greatly in ROM and CMJ, performed two warm-up routines. One warm-up included short (15 s) static stretching followed by 5 tuck jumps, while the other included long static stretching (30 s) followed by 3x5 tuck jumps. ROM and CMJ were measured before, during and for 12 min after the two warm-up routines. Three-way ANOVA showed large differences between the three groups in baseline ROM and CMJ performance. A type of warm-up x time interaction was found for both ROM (p = 0.031) and CMJ (p = 0.016). However, all athletes, irrespective of group, responded in a similar fashion to the different warm-up protocols for both ROM and CMJ, as indicated from the lack of significant interactions for group (condition x group, time x group or condition x time x group). In the short warm-up protocol, ROM was not affected by stretching, while in the long warm-up protocol ROM increased by 5.9% ± 0.7% (p = 0.001) after stretching. Similarly, CMJ remained unchanged after the short warm-up protocol, but increased by 4.6 ± 0.9% (p = 0.012) 4 min after the long warmup protocol, despite the increased ROM. It is concluded that the initial levels of flexibility and CMJ performance do not alter the responses of elite gymnasts to warm-up protocols differing in stretching and potentiating exercise volumes. Furthermore, 3 sets of 5 tuck jumps result in a relatively large increase in CMJ performance despite an increase in flexibility in these highly-trained athletes. © Journal of Sports Science and Medicine.
Donti O, Tsolakis C, Bogdanis GC. Effects of baseline levels of flexibility and vertical jump ability on performance following different volumes of static stretching and potentiating exercises in elite gymnasts. Journal of Sports Science and Medicine [Internet]. 2014;13:105-113. WebsiteAbstract
This study examined the effects of baseline flexibility and vertical jump ability on straight leg raise range of motion (ROM) and counter-movement jump performance (CMJ) following different volumes of stretching and potentiating exercises. ROM and CMJ were measured after two different warm-up protocols involving static stretching and potentiating exercises. Three groups of elite athletes (10 male, 14 female artistic gymnasts and 10 female rhythmic gymnasts) varying greatly in ROM and CMJ, performed two warm-up routines. One warm-up included short (15 s) static stretching followed by 5 tuck jumps, while the other included long static stretching (30 s) followed by 3x5 tuck jumps. ROM and CMJ were measured before, during and for 12 min after the two warm-up routines. Three-way ANOVA showed large differences between the three groups in baseline ROM and CMJ performance. A type of warm-up x time interaction was found for both ROM (p = 0.031) and CMJ (p = 0.016). However, all athletes, irrespective of group, responded in a similar fashion to the different warm-up protocols for both ROM and CMJ, as indicated from the lack of significant interactions for group (condition x group, time x group or condition x time x group). In the short warm-up protocol, ROM was not affected by stretching, while in the long warm-up protocol ROM increased by 5.9% ± 0.7% (p = 0.001) after stretching. Similarly, CMJ remained unchanged after the short warm-up protocol, but increased by 4.6 ± 0.9% (p = 0.012) 4 min after the long warmup protocol, despite the increased ROM. It is concluded that the initial levels of flexibility and CMJ performance do not alter the responses of elite gymnasts to warm-up protocols differing in stretching and potentiating exercise volumes. Furthermore, 3 sets of 5 tuck jumps result in a relatively large increase in CMJ performance despite an increase in flexibility in these highly-trained athletes. © Journal of Sports Science and Medicine.
Batzina A, Dalla C, Papadopoulou-Daifoti Z, Karakatsouli N. Effects of environmental enrichment on growth, aggressive behaviour and brain monoamines of gilthead seabream Sparus aurata reared under different social conditions. Comp Biochem Physiol A Mol Integr Physiol. 2014;169:25-32.Abstract
The presence of blue or red-brown substrate on the tank bottom has been previously reported as an efficient means of environmental enrichment for gilthead seabream. The present study aimed to investigate whether this enrichment is still beneficial when gilthead seabream is reared under different social conditions (i.e. a lower 4.9 kg m(-3) and a higher 9.7 kg m(-3) density). Water exchange was adjusted according to fish biomass to exclude density effects on water quality. In the enriched tanks single-colour glass gravel was used as substrate (blue and red-brown substrate, or BS and RBS respectively), while control tanks had no gravel. Growth, aggressive behaviour and size distribution results indicated that the lower density created a less favourable social environment. In both densities studied, BS enhanced growth, suppressed aggression and reduced brain serotonergic activity. In the condition of intense social interactions (i.e. the lower density) BS also reduced brain dopaminergic activity. These results along with the negative correlations observed between brain monoamines and fish body mass, indicated that substrate and density effects are socially-induced. However, there may be several biotic and/or abiotic factors interfering with substrate effects that should be investigated before the practical use of a substrate in land-based intensive aquaculture.
Kouvelioti R, Vagenas G, Langley-Evans S. The effects of exercise and diet on weight loss maintenance in overweight and obese adults: a systematic review. The Journal of Sport Medicine and Physical Fitness [Internet]. 2014;54(4):456-474. Publisher's VersionAbstract
Overweight and obesity are widespread nutritional disorders. Their treatment aims at effective weight loss (WL) and weight loss maintenance (WLM). Previous systematic reviews show weight regain, after recommended exercise and diet combined. However, certain experimental and methodological inconsistencies in the original studies and in these reviews left space for a substantial revisit of this problem. This study aimed at systematically re-reviewing the effectiveness of exercise combined with diet on WLM in overweight and obese adults. Literature was searched through Embase and Sport Discus (up to 2008), and PubMed (Medline) and ISI Web of science (up to 2012). 14 randomized clinical trials (RCT) were retained, their quality was assessed by the Jadad scale, and detailed methodological and statistical characteristics were evaluated. Overall estimations showed a WL of 11.1 kg (about 13%) after an average of about 4 months from baseline, a WLM of 5.8 kg (about 52%) and a weight regain of 5.1 kg after an average period of about 21 months. WL was successful but almost half of it (about 48%) was regained, which agrees with previous findings. The Jadad score showed very good to excellent quality for all 14 studies. However, further assessment revealed serious weakness such as high average dropout (>20%), not estimating experimental power or not using a control group in more than half of the studies, possible lack of adherence and variability in demographic traits. Future studies may focus on improving these limitations for more accurate results in this crucial research field.
Moustakas AL, Sanguinetti L, Debbah M. Effects of mobility on user energy consumption and total throughput in a massive MIMO system. In: Proc. IEEE Information Theory Workshop (ITW)}. ; 2014. pp. 292-296. arXiV
Bogdanis, G.C. TVTTAPC. Effects of muscle action type with equal impulse of conditioning activity on postactivation potentiation. Journal of Strength and Conditioning Research [Internet]. 2014;28:2521-2528. WebsiteAbstract
This study investigated the effects of muscle action type during conditioning activity (half-squat) on subsequent vertical jump performance. Fourteen track and field athletes (relative half-squat of 2.3 ± 0.3 times their body weight) completed 4 main trials in a randomized and counterbalanced order 5-7 days apart: (a) concentric (CON) halfsquats: 7.5 ± 1.2 repetitions against 90% of 1 repetition maximum (1RM), (b) eccentric (ECC) half-squats: 9.3 ± 1.5 repetitions against 70% of 1RM, and (c) 3 sets of 3-second maximal isometric (ISO) half-squats, (d) a control (CTRL) trial, where subjects rested for 10 minutes. The number of repetitions in CON and ECC was adjusted so that the impulse of the vertical ground reaction force was similar to ISO. Countermovement vertical jump (CMJ) performance was evaluated for 21 minutes after each main trial. Countermovement vertical jump performance in ISO was higher than CTRL from the second to the 10th minute of recovery, whereas CMJ performance in ECC was higher than CTRL from the sixth and 10th minute of recovery. Analysis of the peak individual responses revealed an increase in CMJ performance compared with baseline only in ISO (3.06 1.2%; p = 0.045), whereas no significant increases were observed in ECC and CON. Peak CMJ performance for all subjects in ISO and ECC was achieved within 2-10 minutes after the conditioning muscle actions. Isometric were more effective than CON and ECC muscle actions in increasing explosive leg performance when the impulse of the ground reaction force of the conditioning exercise was equated. © 2014 National Strength and Conditioning Association.
Bogdanis GC, Tsoukos A, Veligekas P, Tsolakis C, Terzis G. Effects of muscle action type with equal impulse of conditioning activity on postactivation potentiation. Journal of Strength and Conditioning Research [Internet]. 2014;28:2521-2528. WebsiteAbstract
This study investigated the effects of muscle action type during conditioning activity (half-squat) on subsequent vertical jump performance. Fourteen track and field athletes (relative half-squat of 2.3 ± 0.3 times their body weight) completed 4 main trials in a randomized and counterbalanced order 5-7 days apart: (a) concentric (CON) halfsquats: 7.5 ± 1.2 repetitions against 90% of 1 repetition maximum (1RM), (b) eccentric (ECC) half-squats: 9.3 ± 1.5 repetitions against 70% of 1RM, and (c) 3 sets of 3-second maximal isometric (ISO) half-squats, (d) a control (CTRL) trial, where subjects rested for 10 minutes. The number of repetitions in CON and ECC was adjusted so that the impulse of the vertical ground reaction force was similar to ISO. Countermovement vertical jump (CMJ) performance was evaluated for 21 minutes after each main trial. Countermovement vertical jump performance in ISO was higher than CTRL from the second to the 10th minute of recovery, whereas CMJ performance in ECC was higher than CTRL from the sixth and 10th minute of recovery. Analysis of the peak individual responses revealed an increase in CMJ performance compared with baseline only in ISO (3.06 1.2%; p = 0.045), whereas no significant increases were observed in ECC and CON. Peak CMJ performance for all subjects in ISO and ECC was achieved within 2-10 minutes after the conditioning muscle actions. Isometric were more effective than CON and ECC muscle actions in increasing explosive leg performance when the impulse of the ground reaction force of the conditioning exercise was equated. © 2014 National Strength and Conditioning Association.
Bogdanis GC, Tsoukos A, Veligekas P, Tsolakis C, Terzis G. Effects of muscle action type with equal impulse of conditioning activity on postactivation potentiation. J Strength Cond Res. 2014;28(9):2521-8.Abstract
This study investigated the effects of muscle action type during conditioning activity (half-squat) on subsequent vertical jump performance. Fourteen track and field athletes (relative half-squat of 2.3 ± 0.3 times their body weight) completed 4 main trials in a randomized and counterbalanced order 5-7 days apart: (a) concentric (CON) half-squats: 7.5 ± 1.2 repetitions against 90% of 1 repetition maximum (1RM), (b) eccentric (ECC) half-squats: 9.3 ± 1.5 repetitions against 70% of 1RM, and (c) 3 sets of 3-second maximal isometric (ISO) half-squats, (d) a control (CTRL) trial, where subjects rested for 10 minutes. The number of repetitions in CON and ECC was adjusted so that the impulse of the vertical ground reaction force was similar to ISO. Countermovement vertical jump (CMJ) performance was evaluated for 21 minutes after each main trial. Countermovement vertical jump performance in ISO was higher than CTRL from the second to the 10th minute of recovery, whereas CMJ performance in ECC was higher than CTRL from the sixth and 10th minute of recovery. Analysis of the peak individual responses revealed an increase in CMJ performance compared with baseline only in ISO (3.0 ± 1.2%; p = 0.045), whereas no significant increases were observed in ECC and CON. Peak CMJ performance for all subjects in ISO and ECC was achieved within 2-10 minutes after the conditioning muscle actions. Isometric were more effective than CON and ECC muscle actions in increasing explosive leg performance when the impulse of the ground reaction force of the conditioning exercise was equated.
Zaras ND, Stasinaki A-NE, Krase AA, Methenitis SK, Karampatsos GP, Georgiadis GV, Spengos KM, Terzis GD. Effects of tapering with light vs. heavy loads on track and field throwing performance. J Strength Cond Res. 2014;28(12):3484-95.Abstract
The purpose of the study was to investigate the effects of power training with light vs. heavy loads during the tapering phases of a double periodized training year on track and field throwing performance. Thirteen track and field throwers aged 16-26 years followed 8 months of systematic training for performance enhancement aiming at 2 tapering phases during the winter and the spring competition periods. Athletes performed tapering with 2 different resistance training loads (counterbalanced design): 7 athletes used 30% of 1 repetition maximum (1RM) light-load tapering (LT), and 6 athletes used the 85% of 1RM heavy-load tapering (HT), during the winter tapering. The opposite was performed at the spring tapering. Before and after each tapering, throwing performance, 1RM strength, vertical jumping, rate of force development (RFD), vastus lateralis architecture, and rate of perceived exertion were evaluated. Throwing performance increased significantly by 4.8 ± 1.0% and 5.6 ± 0.9% after LT and HT, respectively. Leg press 1RM and squat jump power increased more after HT than LT (5.9 ± 3.2% vs. -3.4 ± 2.5%, and 5.1 ± 2.4% vs. 0.9 ± 1.4%, respectively, p ≤ 0.05). Leg press RFD increased more in HT (38.1 ± 16.5%) compared with LT (-2.9 ± 6.7%), but LT induced less fatigue than HT (4.0 ± 1.5 vs. 6.7 ± 0.9, p ≤ 0.05). Muscle architecture was not altered after either program. These results suggest that performance increases similarly after tapering with LT or HT in track and field throwers, but HT leads to greater increases in strength, whole body power, and RFD.
Dimopoulos MA, Swern AS, Li JS, Hussein M, Weiss L, Nagarwala Y, Baz R. Efficacy and safety of long-term treatment with lenalidomide and dexamethasone in patients with relapsed/refractory multiple myeloma. Blood Cancer Journal [Internet]. 2014;4(11). WebsiteAbstract
Data from two randomized pivotal, phase 3 trials evaluating the combination of lenalidomide and dexamethasone in relapsed/refractory multiple myeloma (RRMM) were pooled to characterize the subset of patients who achieved long-term benefit of therapy (progression-free survival ≥3 years). Patients with long-term benefit of therapy (n = 45) had a median duration of treatment of 48.1 months and a response rate of 100%. Humoral improvement (uninvolved immunoglobulin A) was more common in patients with long-term benefit of therapy (79% vs 55%; P = 0.002). Significant predictors of long-term benefit of therapy in multivariate analysis were age < 65 years (P = 0.03), β2-microglobulin <2.5 mg/l (P = 0.002) and fewer prior therapies (P = 0.002). The exposureadjusted incidence rate (EAIR) of grade 3-4 neutropenia was lower in patients with long-term benefit of therapy (13.9 vs 38.2 per 100 patient-years). The EAIR for invasive second primary malignancy was the same in patients with long-term benefit of therapy and other patients (1.7 per 100 patient-years). These findings indicate that patients with RRMM can experience long-term benefit with lenalidomide and dexamethasone treatment with manageable side effects. © 2014 Macmillan Publishers Limited All rights reserved.
Guo T, Papaioannou TG, Aberer K. Efficient indexing and query processing of model-view sensor data in the cloud. Big Data Research. 2014;1:52–65.
Ntountaniotis D, Agelis G, Resvani A, Halabalaki M, Liapakis G, Spyridaki K, Golic Grdadolnik S, Merzel F, Kostidis S, Potamitis C, et al. An efficient synthetic method and theoretical calculations of olmesartan methyl ether: Study of biological function of AT1 antagonism. Combinatorial Chemistry and High Throughput Screening [Internet]. 2014;17(8):642 - 662. Website
Koliopoulou M, Leuschner T. Einleitung: Perspektiven der kontrastiven Linguistik. Germanistische Mitteilungen. 2014;40(1):5-14.
Mavridis S. El Gigante Amapolas de Juan Bautista Alberdi. La teatralidad innovadora de uno de los «proscritos». In: Estudios y homenajes hispanoamericanos. Vol. 2. Ediciones del Orto; 2014. pp. 173-177.
Alexopoulou A, ZERVA ADAMANTÍA. El mensaje publicitario desde la perspectiva pragmática e intercultural. Conference Paper. 2014:1-8.
Palapanidi K. El uso del blog en la clase de ELE. El viejo mundo y el nuevo mundo en la era del diálogo. Actas del XVI Congreso de la Federación Internacional de Estudios sobre América Latina y el Caribe. . 2014:849-855.Abstract
El presente trabajo se centra en el uso de las Tecnologías de Información y Comunicación en la enseñanza del español como lengua extranjera. Nos referimos a una herramienta digital en particular: el blog. Veremos de qué se trata, cómo se puede aprovechar y cuáles son las ventajas de su uso en dicho campo. Por último, presentaremos algunos blogs dedicados a la enseñanza del español, que pueden utilizar tanto los docentes como los mismos estudiantes.   
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Lezi N, Economou A, Barek J. Electrodes modified with bismuth, antimony and tin precursor compounds for electrochemical stripping analysis of trace metals (a short review). Sensing in Electroanalysis.(K. Kalcher, R. Metelka, I. Švancara, K. Vytřas; Eds.). 2013/2014, Volume 8.Sensing in Electroanalysis.(K. Kalcher, R. Metelka, I. Švancara, K. Vytřas; Eds.). 2013/2014, Volume 8. 2014.
Aad G, others. {Electron and photon energy calibration with the ATLAS detector using LHC Run 1 data}. Eur. Phys. J. C. 2014;74:3071.
Aad G, others. {Electron reconstruction and identification efficiency measurements with the ATLAS detector using the 2011 LHC proton-proton collision data}. Eur. Phys. J. C. 2014;74:2941.
Abadias G, Kanoun MB, Goumri-Said S, Koutsokeras L, Dub SN, Djemia P. Electronic structure and mechanical properties of ternary ZrTaN alloys studied by ab initio calculations and thin-film growth experiments. Physical Review B - Condensed Matter and Materials Physics [Internet]. 2014;90. Website
Abadias G, Kanoun MB, Goumri-Said S, Koutsokeras L, Dub SN, Djemia P. Electronic structure and mechanical properties of ternary ZrTaN alloys studied by ab initio calculations and thin-film growth experiments. Physical Review B - Condensed Matter and Materials Physics [Internet]. 2014;90(14). Website
Loupis M. Embedded Systems Development Tools: A MODUS-oriented Market Overview. 2014;5(1):6 - 20.
Loupis M. Embedded Systems Development Tools: A MODUS-oriented Market Overview. Business Systems Research. 2014;5:6–20.
Kritikou V. Cecilia Valdés o La Loma del Ángel de Cirilo Villaverde: Historia y Literatura. In: Estudios y Homenajes Hispanoamericanos II. Vol. 2. 1st ed. Madrid: Ediciones del Orto; 2014. pp. 83-86. Publisher's Version kritikou.cecilia_valdes.historia_y_literatura.pdf
Kritikou V. Complementos sociales. Realismo y Naturalismo en Hispanoamérica. 1st ed. Madrid: Ediciones del Orto; 2014 pp. 96. vivlio3.complementos_sociales_realismo_y_naturalismo.pdf
Krokidis M, Spiliopoulos S, Ahmed I, Gkoutzios P, Sabharwal T, Reidy J. Emergency endovascular management of pulmonary artery aneurysms and pseudoaneurysms for the treatment of massive haemoptysis. Hellenic Journal of Cardiology [Internet]. 2014;55(3):204 - 210. Website
Krokidis M, Spiliopoulos S, Ahmed I, Gkoutzios P, Sabharwal T, Reidy J. Emergency endovascular management of pulmonary artery aneurysms and pseudoaneurysms for the treatment of massive haemoptysis. Hellenic Journal of Cardiology [Internet]. 2014;55:204-210. Website
Pastromas G, Katsanos K, Krokidis M, Karnabatidis D, Spiliopoulos S. Emerging Stent and balloon technologies in the femoropopliteal arteries. The Scientific World Journal [Internet]. 2014;2014. Website
Pastromas G, Katsanos K, Krokidis M, Karnabatidis D, Spiliopoulos S. Emerging Stent and balloon technologies in the femoropopliteal arteries. The Scientific World Journal [Internet]. 2014;2014. Website
Peitho in Nonnus' Dionysiaca. The case of Cadmus and Harmonia. In: Spanoudakis K Nonnus of Panopolis in Context. Poetry and Social Milieu in Late Antiquity. Boston & Berlin: De Gruyter; 2014. pp. 21-38.
<em>Rideamus Igitur... Laughter in Latin Literature: Proceedings of the 8th Panhellenic Symposium of Latin Literature</em>.
Rideamus Igitur.. Laughter in Latin Literature: Proceedings of the 8th Panhellenic Symposium of Latin Literature. (Papaioannou S, Michalopoulos AN, Kikilia M). Athens: National and Kapodistrian University of Athens; 2014. Publisher's Version
ATHANASSOPOULOU EKAVI. Strategic Relations Between the US and Turkey: Sleeping with a Tiger. First. London: Routledge; 2014 pp. 209. Publisher's VersionAbstract
Taking the period from the end of the 1970s to the end of the 1990s, this book critically examines the evolution of the strategic relationship between the US and Turkey during this period, with a particular focus on the Middle Eastern context. Strategic Relations Between the US and Turkey employs interviews with US, Turkish and Israeli officials and archival research in order to offer an alternative reading of the realities that shaped bilateral co-operation through multi-level analysis. The unraveling of these realities enlightens the reader about the past course of events but also aids the understanding of the dynamics of the relationship today. Essential reading for students and scholars of U.S. and Turkish foreign policy, this study of co-operation between a super-power and a relatively weak state in the international system will also be of use to those interested in International Relations, Diplomatic History and World Politics more broadly.
<em>Terence and Interpretation</em>. (Perides Studies in Greek and Latin Literature VI)
Papaioannou S. Terence and Interpretation. (Perides Studies in Greek and Latin Literature VI). Newcastle, UK: Cambridge Scholars Publishing; 2014.
Γογγάκη Κ, Καλογεράκος Ι. Φιλοσοφία και Αθλητισμός. Πρακτικά Β’ Φιλοσοφικού Συμποσίου, 16 Μαΐου 2014. 2014.Abstract
  • (2014). Κωνσταντίνα Γογγάκη – Ιωάννης Γ. Καλογεράκος (επιμ.). Φιλοσοφία και Αθλητισμός. Πρακτικά Β’ Φιλοσοφικού Συμποσίου, Αθήνα, 16 Μαΐου 2014. Έκδοση Σπουδαστηρίου Φιλοσοφίας του Αθλητισμού του ΤΕΦΑΑ Εθνικού και Καποδιστριακού Παν/μίου Αθηνών, εκδόσεις Παπαηλιού, Αθήνα.
2014._filosofia_kai_athlitismos_praktika_2oy_filosofikoy_symposioy.pdf 2014._2o_filosofiko_symposio._filosofia_athlitismos._eisigiseis.pdf
Moustris KP, Nastos PT, Bartzokas A, Larissi IK, Zacharia PT, Paliatsos AG. Energy consumption based on heating/cooling degree days within the urban environment of Athens, Greece. Theoretical and Applied Climatology [Internet]. 2014;122:517-529. Website
Sanguinetti L, Moustakas AL, Björnson E, Debbah M. Energy Consumption in Multi-User MIMO Systems: Impact of User mobility. In: IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP). Florence; 2014. pp. 4743-4747. arXiV
Mitronikas ED, Spyropoulos DV, Papanikolaou NP, Tatakis EC, Spyropoulos N. Energy saving during modern lift operation. In: IEEE; 2014. pp. 756 - 761.
Anastasopoulos MP, Tzanakaki A, Simeonidou D. Energy-aware offloading in mobile cloud systems with delay considerations. In: 2014 IEEE Globecom Workshops, GC Wkshps 2014. ; 2014. pp. 42-47. Website
Anastasopoulos MP, Tzanakaki A, Simeonidou D. Energy-aware offloading in mobile cloud systems with delay considerations. In: ; 2014. pp. 42 - 47. Website
Rapti S-M, Kontos CK, Papadopoulos IN, Scorilas A. Enhanced miR-182 transcription is a predictor of poor overall survival in colorectal adenocarcinoma patients. Clinical Chemistry and Laboratory Medicine (CCLM). 2014;52:1217–1227.
Rapti S-M, Kontos CK, Papadopoulos IN, Scorilas A. Enhanced miR-182 transcription is a predictor of poor overall survival in colorectal adenocarcinoma patients. Clinical Chemistry and Laboratory Medicine. 2014;52:1217-1227.
Rapti S-M, Kontos CK, Papadopoulos IN, Scorilas A. Enhanced miR-182 transcription is a predictor of poor overall survival in colorectal adenocarcinoma patients. Clinical Chemistry and Laboratory Medicine [Internet]. 2014;52:1217-1227. Website
Michou A, Vansteenkiste M, Mouratidis A, Lens W. Enriching the Hierarchical Model of Achievement Motivation: Autonomous and Controlling Reasons Underlying Achievement Goals. British Journal of Educational Psychology. 2014;84:650-666.
Batzina A, Dalla C, Tsopelakos A, Papadopoulou-Daifoti Z, Karakatsouli N. Environmental enrichment induces changes in brain monoamine levels in gilthead seabream Sparus aurata. Physiol Behav. 2014;130:85-90.Abstract
It is generally accepted that environmental enrichment enhances the performance and improves welfare of animals kept in captivity. Similar results have been obtained for fish. It has been previously reported that the presence of Blue or Red-Brown Substrate (BS and RBS respectively) on tank bottom resulted in growth enhancement and suppression of aggressive behavior of gilthead seabream Sparus aurata compared to Green Substrate (GS) and tanks without modifications (Control-C). In an attempt to identify the underlying mechanisms, in the present study the effects of this environmental enrichment on brain monoamine neurotransmitters and fatty acids of gilthead seabream were evaluated. BS and RBS fish had lower serotonergic activity (5-HIAA/5-HT), resulting mainly from lower 5-hydroxyindoleacetic acid (5-HIAA) levels. BS fish also had lower serotonin levels compared to all other treatments. Brain noradrenaline (NA) levels did not show significant differences between substrate treatments and control. Brain dopamine (DA) levels were lowest in BS and RBS fish, higher in GS fish and highest in C fish. No differences were observed for dopamine metabolites or dopaminergic activity. Moreover, brain NA was negatively correlated with body weight in BS fish and positively correlated in RBS and C fish. A positive correlation was also observed for brain DA with body weight in RBS fish. No differences were observed for brain fatty acids. Present results support the hypothesis that the beneficial effects of the presence of BS and RBS are related to altered social interactions and indicate the establishment of a less stressful social organization in enriched-reared fish groups.
Environmental ethics and Linkola's Ecofascism: An ethics way beyond humanism
Protopapadakis ED. Environmental ethics and Linkola's Ecofascism: An ethics way beyond humanism. Frontiers of Philosophy in China [Internet]. 2014;9(4):586-601. Publisher's VersionAbstract
Ecofascism as a tradition in Environmental Ethics seems to burgeoning with potential. The roots of Ecofascism can be traced back to the German Romantic School, to the Wagnerian narration of the Nibelungen saga, to the works of Fichte and Herder and, finally, to the so-called völkisch movement.Those who take pride in describing themselves as ecofascists grosso modo tend to prioritize the moral value of the ecosphere, while, at the same time, they almost entirely devalue species and individuals. Additionally, these ecofascists are eager to reject democracy, the idea of progress in its entirety, as well as industrialization and urbanization. They also seem to be hostile towards individual autonomy and free will. In this short essay I will present and discuss Kaarlo Pentti Linkola’s approach to environmental ethics, one that could be well described as the epitome of Ecofascism. I will argue that his arguments are neither sound nor documented, and I will conclude that Linkola’s overall approach is, in my view, contrary to the purpose as well as to the very essence of morality.
Evangelos D. Protopapadakis, Environmental ethics and Linkola's Ecofascism, An ethics way beyond humanism
Gournelos T, Evelpidou N, Kotinas V. Erosion risk map of Samos Island using a simple probability model. 10th International Congress of the Hellenic Geographical Society, 22-24 October. 2014:656-661.Abstract
part and the Karvouni mountain in the central part. The Geology of Samos consists of a metamorphic substratum, a non metamorphic unit, neogene and quaternary sediments. This island has been affected many times by natural hazards, such as forest fires, soil erosion, flash floods and gravity movements. The aim of this paper is to create an erosion risk map of Samos Island. This has been achieved by a series of separate stages, such as the creation of a database of geological, geomorphological and topographic data, extensive field observations and analyses of aerial photos and satellite images, within a GIS based platform. The final step involves the application of a functional relationship based on a probability model to input data consisting of the lithology, slope, mean altitude, and the vegetation-land use for each drainage basin to produce the final erosion risk map.
Armeni E, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A. Erratum: Arterial stiffness is increased in asymptomatic non-diabetic postmenopausal women with a PCOS phenotype (Journal of Hypertension (2013) 31 (1998-2004)). Journal of Hypertension. 2014;32(3):702 - 702.
Spinoglio L, Dasyra KM, Franceschini A, Gruppioni C, Valiante E, Isaak K. Erratum:“Far-IR/Submillimeter Spectroscopic Cosmological Surveys: Predictions of Infrared Line Luminosity Functions for z< 4 Galaxies”(2012, ApJ, 745, 171). The Astrophysical Journal. 2014;791:138.
Alexopoulos JD, Dilalos S, Tsatsaris A, Mavroulis S. ERT and VLF measurements contributing to the extended revelation of the ancient town of Trapezous, (Megalopolis, Peloponnesus, Greece). In: 20th European Meeting of Environmental and Engineering Geophysics. Vol. Mo_PA2_05. Athens, Greece; 2014. pp. 5. Publisher's VersionAbstract
A geophysical survey was carried out in the archaeological site of Kyparissia (Megalopolis, Greece) applying the Very Low Frequency technique, as preliminary combined with highly detailed Electrical Resistivity Tomography. Settlements of the ancient city of Trapezous (limestone slabs 0.5m height × 0.5m width) have already been uncovered from the local Ephorate of Prehistorical and Classical Antiquities, revealing a regularly planned town of the classical period. The geophysical research was performed at the non-excavated area of the plain, vicinal to the already exposed remaining, where, according to the expected geometry, the buried walls and drainage channel should be continued to. Fifteen parallel sections with distance 5m and spacing interval 1m were carried out. The processing with the application of Fraser and Karous-Hjelt filters led to the construction of respective maps, indicating some resistive lineation which could be a result of the buried settlements. Moreover, two detailed ERT sections were carried out with spacing 0.20 and 0.25m and total length 200m. The processing using the robust inversion, which is indicated for such environments, adumbrates quite clearly a sharp resistive target that could be the limestone slabs of the ancient walls or drainage channels, confirming the expected lineated geometry of the town.
Herbert A, Cruickshank JK, Laurent S, Boutouyrie P, Shimada K, Kario K, Miyashita H, Eguchi K, Kohara K, Tabara Y, et al. Establishing reference values for central blood pressure and its amplification in a general healthy population and according to cardiovascular risk factors. European Heart Journal [Internet]. 2014;35(44):3122 - 3133. Website
Herbert A, Cruickshank JK, Laurent S, Boutouyrie P, Shimada K, Kario K, Miyashita H, Eguchi K, Kohara K, Tabara Y, et al. Establishing reference values for central blood pressure and its amplification in a general healthy population and according to cardiovascular risk factors. European Heart Journal [Internet]. 2014;35(44):3122 - 3133. Website
Tsiachristos I, Varouti E, Manios E, Stamopoulos D, Zervos T, Fikioris G, Lazarakis F, Alexandridis A, Pissas M. Estimation of permeability tensor and dielectric permittivity of ferrites using a wave guide method under a dc magnetic field Niarchos D, Hadjipanayis G, Kalogirou O. JEMS 2013 - JOINT EUROPEAN MAGNETIC SYMPOSIA. 2014;75(7th Joint European Magnetic Symposia (JEMS).Abstract
Using a vector network analyzer equipped with a calibrated rectangular wave guide the electric permittivity and the element of the magnetic permeability tensor for Y3Fe5O12, ZnFe2O4 and NiFe2O4 are measured. The electric permittivity can be estimated from the body resonances (d = n lambda/2) if a sufficient long sample is used. The estimation of the magnetic permeability tensors' parameters can be estimated comparing the experimental results with computer simulations using the magnetic properties of the materials as derived from the magnetic measurements.
Estudios y Homenajes Hispanoamericanos II. (Pavlakis EP, DROSOS DIMITRIOS, PAPAGEORGIOU ANTHI). Madrid: Ediciones del Orto ; 2014. Publisher's Version
ESTUDIOS Y HOMENAJES
HISPANOAMERICANOS II
. FIRST. (Pavlakis EP, Drosos DL, PAPAGEORGIOU ANTHI). Madrid: Ediciones del Orto; 2014 pp. 286. estudios_y_homenajes_ii.pdf
Engelhardt M, Terpos E, Kleber M, Gay F, Wäsch R, Morgan G, Cavo M, van de Donk N, Beilhack A, Bruno B, et al. European myeloma network recommendations on the evaluation and treatment of newly diagnosed patients with multiple myeloma. Haematologica [Internet]. 2014;99(2):232 - 242. WebsiteAbstract
Multiple myeloma management has undergone profound changes in the past thanks to advances in our understanding of the disease biology and improvements in treatment and supportive care approaches. This article presents recommendations of the European Myeloma Network for newly diagnosed patients based on the GRADE system for level of evidence. All patients with symptomatic disease should undergo risk stratification to classify patients for International Staging System stage (level of evidence: 1A) and for cytogenetically defined high- versus standard-risk groups (2B). Novel-agent-based induction and up-front autologous stem cell transplantation in medically fit patients remains the standard of care (1A). Induction therapy should include a triple combination of bortezomib, with either adriamycin or thalidomide and dexamethasone (1A), or with cyclophosphamide and dexamethasone (2B). Currently, allogeneic stem cell transplantation may be considered for young patients with high-risk disease and preferably in the context of a clinical trial (2B). Thalidomide (1B) or lenalidomide (1A) maintenance increases progression-free survival and possibly overall survival (2B). Bortezomib-based regimens are a valuable consolidation option, especially for patients who failed excellent response after autologous stem cell transplantation (2A). Bortezomib-melphalan-prednisone or melphalan-prednisone-thalidomide are the standards of care for transplant-ineligible patients (1A). Melphalan-prednisone-lenalidomide with lenalidomide maintenance increases progression-free survival, but overall survival data are needed. New data from the phase III study (MM-020/IFM 07-01) of lenalidomide-low-dose dexamethasone reached its primary end point of a statistically significant improvement in progression-free survival as compared to melphalan-prednisone-thalidomide and provides further evidence for the efficacy of lenalidomide-low-dose dexamethasone in transplant-ineligible patients (2B). © 2013 Ferrata Storti Foundation.
Ludwig H, Sonneveld P, Davies F, Bladé J, Boccadoro M, Cavo M, Morgan G, De La Rubia J, Delforge M, Dimopoulos M, et al. European perspective on multiple myeloma treatment strategies in 2014. Oncologist [Internet]. 2014;19(8):829 - 844. WebsiteAbstract
The treatment of multiple myeloma has undergone significant changes and has resulted in the achievement of molecular remissions, the prolongation of remission duration, and extended survival becoming realistic goals, with a cure being possible in a small but growing number of patients. In addition, nowadays it is possible to categorize patients more precisely into different risk groups, thus allowing the evaluation of therapies in different settings and enabling a better comparison of results across trials. Here, we review the evidence from clinical studies, which forms the basis for our recommendations for the management of patients with myeloma. Treatment approaches depend on "fitness," with chronological age still being an important discriminator for selecting therapy. In younger, fit patients, a short three drug-based induction treatment followed by autologous stem cell transplantation (ASCT) remains the preferred option. Consolidation and maintenance therapy are attractive strategies not yet approved by the European Medicines Agency, and a decision regarding post-ASCT therapy should only be made after detailed discussion of the pros and cons with the individual patient. Two- and three-drug combinations are recommended for patients not eligible for transplantation. Treatment should be administered for at least nine cycles, although different durations of initial therapy have only rarely been compared so far. Comorbidity and frailty should be thoroughly assessed in elderly patients, and treatment must be adapted to individual needs, carefully selecting appropriate drugs and doses. A substantial number of new drugs and novel drug classes in early clinical development have shown promising activity. Their introduction into clinical practice will most likely further improve treatment results. © AlphaMed Press.
Ponirou P, Diomidous M, Mantas J, Kalokairinou A, Kalouri O, Kapadochos T, Tzavara C. Evaluating a Health Educational First aid Program with the Implementation of Synchronous Distance Learning. Stud Health Technol Inform. 2014;202:56-9.Abstract
The education in First Aid through health education programs can help in promoting the health of the population. Meanwhile, the development of alternative forms of education with emphasis on distance learning implemented with e-learning creates an innovative system of knowledge and skills in different population groups. The main purpose of this research proposal is to investigate the effectiveness of the educational program to candidates educators about knowledge and emergency preparedness at school. The study used the Solomon four group design (2 intervention groups and 2 control groups). Statistical analysis showed significant difference within the four groups. Intervention groups had improved significantly their knowledge showing that the program was effective and that they would eventually deal with a threatening situation with right handlings. There were no statistical significant findings regarding other independent variables (p>0,05).The health education program with the implementation of synchronous distance learning succeeded to enhance the knowledge of candidates educators.
Andreopoulou A, Roginska A. Evaluating HRTF Similarity through Subjective Assessments: Factors that can Affect Judgment. In: ICMC. ; 2014.
Zerva A, Savvides AL, Katsifas EA, Karagouni AD, Hatzinikolaou DG. Evaluation of Paecilomyces variotii potential in bioethanol production from lignocellulose through consolidated bioprocessing. Bioresource Technology [Internet]. 2014;162:294-299. Publisher's VersionAbstract
The ascomycete Paecillomyces variotii was evaluated for the first time as a candidate species for the production of bioethanol from lignocellulose through consolidated bioprocessing (CBP) approaches. The examined strain (ATHUM 8891) revealed all the necessary phenotypic characteristics required for 2nd generation biofuel production. The fungus is able to efficiently ferment glucose and xylose to ethanol, with yields close to the theoretical maximum. Nitrogen supplementation greatly affected ethanol production with nitrate-nitrogen presenting the best results. Notably, ethanol yield on xylose fermentation was higher than that of glucose, while in co-fermentation of glucose–xylose mixtures no distinguished diauxic behavior was observed. Furthermore, the fungus seems to possess the necessary enzyme factory for the degradation of lignocellulosic biomass, as it was able to grow and produce ethanol on common agro-industrial derivatives. Overall, the results of our study indicate that P. variotii is a new and possibly powerful candidate for CBP applications.
Olson AD, Meyer L, Prins M, Thiebaut R, Gurdasani D, Guiguet M, Chaix M-L, Amornkul P, Babiker A, Sandhu MS, et al. An evaluation of HIV elite controller definitions within a large seroconverter cohort collaboration. PloS one. 2014;9:e86719.
Olson AD, Guiguet M, Zangerle R, Gill J, Perez-Hoyos S, Lodi S, Ghosn J, Dorrucci M, Johnson A, Sannes M, et al. Evaluation of rapid progressors in HIV infection as an extreme phenotype. Journal of acquired immune deficiency syndromes (1999). 2014;67:15.
Siskou O, Galanis P, Kaitelidou D, Kalogeropoulou M, Kouli E, Thireos E, Vafeiadis J, Theodorou M, Prezerakos P, Lemonidou C, et al. Evaluation of Selected Ken-Drgs in Greek Public Hospitals: The Degree to Which they Reflect Actual Expenditure and Average Length of Stay. Value in Health. 2014;17:A602.
Siskou O, Galanis P, Kaitelidou D, Kalogeropoulou M, Kouli E, Thireos E, Vafeiadis J, Theodorou M, Prezerakos P, Lemonidou C. Evaluation of Selected Ken-Drgs in Greek Public Hospitals: The Degree to Which they Reflect Actual Expenditure and Average Length of Stay. Value in Health. 2014;17(7):A602.
Christodouleas DC, Fotakis C, Papadopoulos K, Calokerinos AC. Evaluation of total reducing power of edible oils. Talanta [Internet]. 2014;130:233-240. Website
Triantaphyllou MV, Gogou A, Bouloubassi I, Dimiza M, Kouli K, Rousakis G, Kotthoff U, Emeis K-C, Papanikolaou M, Athanasiou M, et al. Evidence for a warm and humid Mid-Holocene episode in the Aegean and northern Levantine Seas (Greece, NE Mediterranean). Regional Environmental Change [Internet]. 2014;14(5):1697 - 1712. Publisher's VersionAbstract
Marine and terrestrial biological and biogeochemical proxies in three sediment cores from North and SE Aegean and northern Levantine Seas record continuous warm and humid conditions between 5.5 and 4.0 ka BP related to the establishment of relatively stratified conditions in the upper water column. These conditions may have resulted from the concordant albeit weak Mid-Holocene South Asian monsoon forcing, combined with lighter Etesian winds. During this interval, sea surface temperatures fluctuate in the Aegean Sea, although exhibiting a strong positive shift at*4.8 ka BP. The warm and humid climatic conditions triggered upper water column stratification and enhancement of the deep chlorophyll maximum (DCM), leading to dysoxic conditions and the deposition of a sapropel-like layer, but only in the SE Aegean site. In contrast to the shallow water SE Aegean, the deeper North Aegean and the northern Levantine sites, although experiencing stratification in the upper parts of the water column, did not achieve bottom-water dysoxia. Thus, a top–bottom mechanism of stratification–DCM development accompanied by fast transport and burial of organic matter is a likely explanation for the preservation of productivity signal in the shallow sites of the SE Aegean and establishment of sapropelic conditions during the warm and humid Mid-Holocene. The termination of the Mid-Holocene warm and humid phase coincides with the ‘‘4.2 ka’’ climate event. Our data exhibit an N–S time transgressive aridification gradient around the Aegean Sea, most probably associated with the reorganization of the general atmospheric circulation during the Mid-Holocene.
Triantaphyllou MV, Gogou A, Bouloubassi I, Dimiza M, Kouli K, Rousakis G, Kotthoff U, Emeis K-C, Papanikolaou M, Athanasiou M, et al. Evidence for a warm and humid Mid-Holocene episode in the Aegean and northern Levantine Seas (Greece, NE Mediterranean). Regional Environmental Change [Internet]. 2014;14(5):1697 - 1712. Publisher's VersionAbstract
Marine and terrestrial biological and biogeochemical proxies in three sediment cores from North and SE Aegean and northern Levantine Seas record continuous warm and humid conditions between 5.5 and 4.0 ka BP related to the establishment of relatively stratified conditions in the upper water column. These conditions may have resulted from the concordant albeit weak Mid-Holocene South Asian monsoon forcing, combined with lighter Etesian winds. During this interval, sea surface temperatures fluctuate in the Aegean Sea, although exhibiting a strong positive shift at*4.8 ka BP. The warm and humid climatic conditions triggered upper water column stratification and enhancement of the deep chlorophyll maximum (DCM), leading to dysoxic conditions and the deposition of a sapropel-like layer, but only in the SE Aegean site. In contrast to the shallow water SE Aegean, the deeper North Aegean and the northern Levantine sites, although experiencing stratification in the upper parts of the water column, did not achieve bottom-water dysoxia. Thus, a top–bottom mechanism of stratification–DCM development accompanied by fast transport and burial of organic matter is a likely explanation for the preservation of productivity signal in the shallow sites of the SE Aegean and establishment of sapropelic conditions during the warm and humid Mid-Holocene. The termination of the Mid-Holocene warm and humid phase coincides with the ‘‘4.2 ka’’ climate event. Our data exhibit an N–S time transgressive aridification gradient around the Aegean Sea, most probably associated with the reorganization of the general atmospheric circulation during the Mid-Holocene.
Zerefos CS, Tourpali K, Zanis P, Eleftheratos K, Repapis C, Goodman A, Wuebbles D, Isaksen ISA, Luterbacher J. Evidence for an earlier greenhouse cooling effect in the stratosphere before 1980 over the Northern Hemisphere. Atmos. Chem. Phys. [Internet]. 2014;14:7705–7720. Publisher's Version a24_acp_2014.pdf
Aad G, others. {Evidence for Electroweak Production of $W^{\pm}W^{\pm}jj$ in $pp$ Collisions at $\sqrt{s}=8$ TeV with the ATLAS Detector}. Phys. Rev. Lett. 2014;113:141803.
Evelpidou N, Melini D, Pirazzoli P, Vassilopoulos A. Evidence of repeated Late Holocene subsidence in the SE Cyclades (Greece) deduced from submerged notches. International Journal of Earth Sciences. 2014;103 (1):381-395.Abstract
An underwater geomorphological survey along the coasts of six Cycladic islands (Sifnos, Antiparos, Paros, Naxos, Iraklia and Keros) revealed widespread evidence of seven submerged tidal notches. At least seven former shorelines were identified at depths between 280 ± 20 and 30 ± 5 cm below modern sea level. The vertical succession of several submerged notches suggests the occurrence of rapid subsidence events, potentially of seismic origin. Comparison with other sea-level indicators from Naxos and Delos islands indicates that these relative sea-level changes took place after 3300 BP and provides a rough estimate of the time of development of several submerged shorelines. The submergence of the uppermost notch at −30 ± 5 cm is ascribed to effects of the recent global sea-level rise occurred during the last two centuries and, at least in part, to effects of recent earthquakes. Potential effects of the 1956 Amorgos earthquake with regard to coseismic and post-seismic vertical displacement have been recently investigated using a modellistic approach. According to the above, the lower shorelines should result from repetitive subsidence events and not from gradual subsidence.
Gardelis S, Nassiopoulou AG. Evidence of significant down-conversion in a Si-based solar cell using CuInS2/ZnS core shell quantum dots. Applied Physics Letters [Internet]. 2014;104. WebsiteAbstract
We report on the increase of up to 37.5% in conversion efficiency of a Si-based solar cell after deposition of light-emitting Cd-free, CuInS 2/ZnS core shell quantum dots on the active area of the cell due to the combined effect of down-conversion and the anti- reflecting property of the dots. We clearly distinguished the effect of down-conversion from anti-reflection and estimated an enhancement of up to 10.5% in the conversion efficiency due to down-conversion. © 2014 AIP Publishing LLC.
Vansteenkiste M, Mouratidis A, Van Riet T, Lens W. Examining Correlates of Game-to-Game Variation in Volleyball Players' Achievement Goal Pursuit and Underlying Autonomous and Controlling Reasons. Journal of Sport & Exercise PsychologyJournal of Sport & Exercise Psychology. 2014;36:131-145.
Arabatzis T. Experiment. In: M. Curd and S. Psillos (eds), The Routledge Companion to Philosophy of Science. 2nd ed. London: Routledge; 2014. pp. 191-202. Publisher's Version
Stamopoulos D, Zhang SJ. Experimental estimation of d(ij) coefficients of piezoelectric materials by means of optical microscopy Niarchos D, Hadjipanayis G, Kalogirou O. JEMS 2013 - JOINT EUROPEAN MAGNETIC SYMPOSIA. 2014;75(7th Joint European Magnetic Symposia (JEMS).Abstract
The properties of multiferroic and specifically piezoelectric (PE) materials are, nowadays, intensively investigated by means of well established, however relatively complicate methods. In this work we present a method for the direct visual demonstration of the underlying electro-mechanical processes occurring in PE materials and the estimation of the respective coefficients d(ij). The method is based on the utilization of optical microscopy for the local observation of the deformation of a PE specimen upon application of an electric field. The direct comparison of the snapshots obtained before and after application of the electric field and simple algebraic calculations enables the estimation of the d(ij) coefficients. The method was evaluated in unpoled single crystals of 0.71Pb(Mg1/3Nb2/3)O-3-0.29PbTiO(3), at room temperature. Various locations of each crystal surface were surveyed. Non-homogeneous electro-mechanical response was observed. Accordingly, the estimated d(ij) coefficients depended on the specific location of the crystal surface. Specifically, the d(zx) coefficient ranged within 500-1000 pm/V over the investigated locations (for electric fields E<1kV/mm). The present method directly unveils non-homogeneous electro-mechanical processes occurring at the surface of PE crystals and clarifies how these observations can be quantified through the respective d(ij) coefficients.
Tasolamprou AC, Zhang L, Kafesaki M, Koschny T, Soukoulis CM. Experimentally excellent beaming in a two-layer dielectric structure. Optics Express [Internet]. 2014;22:23147 – 23152. Website
Dimopoulos MA, Leleu X, Palumbo A, Moreau P, Delforge M, Cavo M, Ludwig H, Morgan GJ, Davies FE, Sonneveld P, et al. Expert panel consensus statement on the optimal use of pomalidomide in relapsed and refractory multiple myeloma. Leukemia [Internet]. 2014;28(8):1573 - 1585. WebsiteAbstract
In this report, a panel of European myeloma experts discuss the role of pomalidomide in the treatment of relapsed and refractory multiple myeloma (RRMM). Based on the available evidence, the combination of pomalidomide and low-dose dexamethasone is a well-tolerated and effective treatment option for patients with RRMM who have exhausted treatment with lenalidomide and bortezomib. The optimal starting dose of pomalidomide is 4 mg given on days 1-21 of each 28-day cycle, whereas dexamethasone is administered at a dose of 40 mg weekly (reduced to 20 mg for patients aged >75 years). The treatment should continue until evidence of disease progression or unacceptable toxicity. Dose-modification schemes have been established for patients who develop neutropenia, thrombocytopaenia and other grade 3-4 adverse events during pomalidomide therapy. Guidance on the prevention and management of infections and venous thromboembolism is provided, based on the available clinical evidence and the experience of panel members. The use of pomalidomide in special populations, such as patients with advanced age, renal impairment or unfavourable cytogenetic features, is also discussed. © 2014 Macmillan Publishers Limited. All rights reserved.
C N, HC K, M D, CA D, I Z. Exploiting the anti-inflammatory properties of olive (Olea europaea) in the sustainable production of functional food and neutraceuticals. Phytochemistry Reviews [Internet]. 2014;13:445-458. Publisher's VersionAbstract
Olive oil is an important lipid source of the Mediterranean diet which has been associated with lower incidence of cardiovascular diseases whereas olive pomace (OP), a natural by-product of olive oil production, has been found to contain micro constituents with antioxidant, antithrombotic and antiatherogenic activities. The evaluation of OP in order to produce sustainable functional food and neutraceuticals has been the subject of research over the last years. All recent data, focusing on the anti-inflammatory properties of olive oil derived from olive (Olea europaea) and OP along with the potential production of sustainable functional food and neutraceuticals, are presented in this review.
Manifava E, Kolokathi A, Mantas J. Exploring the biomedical and health informatics educational programs in europe. Stud Health Technol Inform. 2014;202:67-70.Abstract
The Health Information Technology can improve public health, quality of health care etc. Thus, it is important for professionals to be well educated by training programs. The aim of this paper is to record all the educational programs with specializations in Health Informatics, Medical Informatics, Bioinformatics, Biomedical Informatics and Biomedical Engineering in European Universities and Institutions. An on-line research was conducted on Scopus, PubMed, Scholar Google, and Google. More than 150 universities and colleges in Europe conduct educational programs for these domains. The majority them, expertise in Biomedical Engineering (31%), 22% of the educational programs correspond to Bioinformatics, while Health Informatics studies have 18%. On the last few years, a growth of Health informatics professionals has been observed in Europe.
Yan D, Carretero-González R, Frantzeskakis DJ, Kevrekidis PG, Proukakis NP, Spirn D. Exploring vortex dynamics in the presence of dissipation: Analytical and numerical results. Physical Review A - Atomic, Molecular, and Optical Physics [Internet]. 2014;89. Website
Kaskaoutis DG, Rashki A, Houssos EE, Goto D, Nastos PT. Extremely high aerosol loading over Arabian Sea during June 2008: The specific role of the atmospheric dynamics and Sistan dust storms. Atmospheric Environment [Internet]. 2014;94:374 - 384. WebsiteAbstract
This study focuses on analyzing the extreme aerosol loading and the mechanisms, source areas and meteorological conditions that favored the abnormal dust exposure towards Arabian Sea during June 2008. The analysis reveals that the spatial-averaged aerosol optical depth (AOD) over Arabian Sea in June 2008 is 0.5 (78.2%) higher than the 2000-2013 mean June value and is mostly attributed to the enhanced dust activity and several (18) dust storms originated from the Sistan region (Iran-Afghanistan borders). Landsat images show that the marshy lakes in Sistan basin got dried during the second half of June 2008 and the alluvial silt and saline material got easily eroded by the intense Levar winds, which were stronger (>15-20ms-1) than the climatological mean for the month of June. These conditions led to enhanced dust exposure from Sistan that strongly affected the northern and central parts of the Arabian Sea, as forward air-mass trajectories show. The NCEP/NCAR reanalysis reveals an abnormal intensification and spatial expansion of the Indian low pressure system towards northern Arabian Sea in June 2008. This suggests strengthening of the convection over the arid southwest Asia and exposure of significant amount of dust, which can reach further south over Arabian Sea favored by the enhanced cyclonic circulation. MODIS imagery highlighted several dust storms originated from Sistan and affecting Arabian Sea during June 2008, while the SPRINTARS model simulations of increased AOD and dust concentration over Sistan and downwind areas are in agreement with ground-based and satellite observations. © 2014 Elsevier Ltd.
K$\alpha$$μ$$π$$\varepsilon$$\rho$$\acuteıota}$$δ$o$\upsilon$ E$ıota$$\rho$$\acuteη$$ν$$η$. E$π$$ıota$$\tau$$\acute{\varepsilon}$$łambda$o$\upsilon$$ς$ A$ν$$\alpha$$π$$ν$$\acute{\varepsilon}$$ømega$ E$łambda$$\varepsilon$$\acuteν$$þeta$$\varepsilon$$\rho$$η$! $\Gamma$$\upsilon$$ν$$\alpha$$ıota$$ąppa$$\varepsilon$$\acuteıota}$$\va. 2014.
Karousou E, Asimakopoulou A, Monti L, Zafeiropoulou V, Afratis N, Gartaganis P, Rossi A, Passi A, Karamanos NK. FACE analysis as a fast and reliable methodology to monitor the sulfation and total amount of chondroitin sulfate in biological samples of clinical importance. MoleculesMolecules. 2014;19:7959-80.Abstract
Glycosaminoglycans (GAGs) due to their hydrophilic character and high anionic charge densities play important roles in various (patho)physiological processes. The identification and quantification of GAGs in biological samples and tissues could be useful prognostic and diagnostic tools in pathological conditions. Despite the noteworthy progress in the development of sensitive and accurate methodologies for the determination of GAGs, there is a significant lack in methodologies regarding sample preparation and reliable fast analysis methods enabling the simultaneous analysis of several biological samples. In this report, developed protocols for the isolation of GAGs in biological samples were applied to analyze various sulfated chondroitin sulfate- and hyaluronan-derived disaccharides using fluorophore-assisted carbohydrate electrophoresis (FACE). Applications to biologic samples of clinical importance include blood serum, lens capsule tissue and urine. The sample preparation protocol followed by FACE analysis allows quantification with an optimal linearity over the concentration range 1.0-220.0 microg/mL, affording a limit of quantitation of 50 ng of disaccharides. Validation of FACE results was performed by capillary electrophoresis and high performance liquid chromatography techniques.
Nakagawa F, Grp NHPW, Ep COHIV, others. Factors associated with short-term changes in HIV viral load and CD4 R cell count in antiretroviral-naive individuals. Aids. 2014;28:1351–1356.
Dimopoulos MA, Palumbo A, Hajek R, Kropff M, Petrucci MT, Lewis P, Millar S, Zhang J, Mei J, Delforge M. Factors that influence health-related quality of life in newly diagnosed patients with multiple myeloma aged ≥ 65 years treated with melphalan, prednisone and lenalidomide followed by lenalidomide maintenance: Results of a randomized trial. Leukemia and Lymphoma [Internet]. 2014;55(7):1489 - 1497. WebsiteAbstract
In the MM-015 trial, melphalan-prednisone-lenalidomide followed by lenalidomide maintenance (MPR-R) significantly prolonged progression-free survival versus melphalan-prednisone (MP) in newly diagnosed patients with multiple myeloma aged ≥ 65 years. Health-related quality of life (HRQoL), a secondary endpoint of MM-015, was also improved with MPR-R. This sub-analysis evaluated the impact of individual predictive factors on HRQoL. Patients completed HRQoL questionnaires at baseline, every third cycle and at progressive disease (PD)/treatment discontinuation. In a mixed-effects model female gender, advanced age and PD negatively affected HRQoL while better treatment responses showed positive effects. Compared to PD, HRQoL during MPR-R treatment was statistically significantly better in two of six preselected domains both of which were also clinically meaningful. HRQoL scores at end of treatment were all either improved or not statistically significantly different versus baseline. In conclusion, continuous treatment with MPR-R, which delays PD, appears to be associated with clinically meaningful improvements in HRQoL. © 2014 Informa UK, Ltd.
Demetrios AAD, Costas P, Iordanis M, Evangelia K, Despina S, Cokkinos DV. Failing hearts after experimental myocardial infarction are characterized by calcium cycling deregulation, apoptosis activation and pathological kinase expression at the infarct border zone: P984. European Journal of Heart Failure. 2014;16.
Kapritsou M, Korkolis DP, Giannakopoulou M, Kaklamanos I, Elefsiniotis IS, Mariolis-Sapsakos T, Birbas K, Konstantinou EA. Fast-track recovery after major liver and pancreatic resection from the nursing point of view. Gastroenterol Nurs. 2014;37(3):228-33.Abstract
Postoperative fast-track recovery protocols combine various methods to support immediate care of patients who undergo major surgery. These protocols include control of postoperative pain and early beginning of oral diet and mobilization. The combination of these approaches may reduce the rate of postoperative complications and facilitate hospital discharge. The aim of this study was to evaluate progress and parameters of fast-track recovery after major liver and pancreatic resection. A descriptive bibliographical review from 2001 to 2012 via electronic databases such as MEDLINE, PubMed, and Google Scholar was undertaken. Articles that focused on a fast-track protocol were studied. Reports focusing on the implementation of a fast-track protocol in the postoperative recovery of patients after major hepatectomy or pancreatectomy were selected. Fast-track protocols may be applicable to patients recovering after major liver or pancreatic resection. Future research should be focused on particular parameters of the fast-track protocol separately.
Zagouri F, Sergentanis TN, Tsigginou A, Dimitrakakis C, Zografos GC, Dimopoulos M-A, Psaltopoulou T. Female breast cancer in Europe: Statistics, diagnosis and treatment modalities. Journal of Thoracic Disease [Internet]. 2014;6(6):589 - 590. Website
Aad G, others. {Fiducial and differential cross sections of Higgs boson production measured in the four-lepton decay channel in $pp$ collisions at $\sqrt{s}$=8 TeV with the ATLAS detector}. Phys. Lett. B. 2014;738:234–253.
Loupis M. Final Market Assessment and Business Plan. 2014.
Kamberidou I. "Finally Free to Breathe", Women’s Accounts: women travellers of the 17th, 18th and 19th centuries. Telethrio S.A., Athens [Book in Greek]; 2014.
Kenourgios D. On financial contagion and implied market volatility. International Review of Financial Analysis [Internet]. 2014;34:21-30. Website
Kouvelis VN, Teshima H, Bruce D, Detter C, Tapia R, Han C, Tampakopoulou V-O, Goodwin L, Woyke T, Kyrpides NC, et al. Finished Genome of Zymomonas mobilis subsp. mobilis Strain CP4, an Applied Ethanol Producer. Genome Announc. 2014;2(1).Abstract
Zymomonas mobilis subsp. mobilis is one of the most rigorous ethanol-producing organisms known to date, considered by many to be the prokaryotic alternative to yeast. The two most applied Z. mobilis subsp. mobilis strains, ZM4 and CP4, derive from Recife, Brazil, and have been isolated from sugarcane fermentations. Of these, ZM4 was the first Z. mobilis representative strain to be sequenced and analyzed. Here, we report the finishing of the genome sequence of strain CP4, which is highly similar but not identical to that of ZM4.
Athanasopoulou E, Rieger D, Walter C, Vogel H, Karali A, Hatzaki M, Gerasopoulos E, Vogel B, Giannakopoulos C, Gratsea M, et al. Fire risk, atmospheric chemistry and radiative forcing assessment of wildfires in eastern Mediterranean. Atmospheric Environment [Internet]. 2014;95:113 - 125. Website
Worm M, Moneret-Vautrin A, Scherer K, Lang R, Fernandez-Rivas M, Cardona V, Kowalski ML, Jutel M, Poziomkowska-Gesicka I, Papadopoulos NG, et al. First European data from the network of severe allergic reactions (NORA). Allergy. 2014;69(10):1397-404.Abstract
BACKGROUND: Occurrence, elicitors and treatment of severe allergic reactions are recognized and reported differently between countries. We aimed to collect standardized data throughout Europe on anaphylaxis referred for diagnosis and counselling. METHODS: Tertiary allergy, dermatology and paediatric units in 10 European countries took part in this pilot phase of the first European Anaphylaxis Registry, from June 2011 to March 2014. An online questionnaire was used to collect data on severe allergic reactions based on the medical history and diagnostics. RESULTS: Fifty-nine centres reported 3333 cases of anaphylaxis, with 26.7% below 18 years of age. Allergic reactions were mainly caused by food (children and adults 64.9% and 20.2%, respectively) and insect venom (20.2% and 48.2%) and less often by drugs (4.8% and 22.4%). Most reactions occurred within 30 min of exposure (80.5%); a delay of 4+ hours was mainly seen in drug anaphylaxis (6.7%). Symptom patterns differed by elicitor, with the skin being affected most often (84.1%). A previous, usually milder reaction to the same allergen was reported by 34.2%. The mainstay of first-line treatment by professionals included corticoids (60.4%) and antihistamines (52.8%). Only 13.7% of lay- or self-treated reactions to food and 27.6% of insect anaphylaxis received on-site adrenaline. CONCLUSION: This pilot phase of a pan-European registry for severe allergic reactions provides for the first time data on anaphylaxis throughout Europe, demonstrates its potential functionality and allows a comparison of symptom patterns, elicitors and treatment habits between referral centres and countries.
Papaioannou TG, Soulis D, Vardoulis O, Protogerou A, Sfikakis PP, Stergiopulos N, Stefanadis C. First in vivo application and evaluation of a novel method for non-invasive estimation of cardiac output. Medical Engineering and Physics [Internet]. 2014;36(10):1352 - 1357. Website
Papaioannou TG, Soulis D, Vardoulis O, Protogerou A, Sfikakis PP, Stergiopulos N, Stefanadis C. First in vivo application and evaluation of a novel method for non-invasive estimation of cardiac output. Medical Engineering and Physics [Internet]. 2014;36(10):1352 - 1357. Website
Fish farming and malaria in modern Greece: conflicting interests or tragedy of the commons?
Gardikas K. Fish farming and malaria in modern Greece: conflicting interests or tragedy of the commons?. In: Franchomme M, Labeur C, Quatrida D, Simonetti R Les zones humides méditerranéennes hier et aujourd’hui - Le zone umide mediterranee ieri e oggi. Padova: Padova University Press; 2014.
Urgel JI, Ecija D, Auwärter W, Papageorgiou AC, Seitsonen AP, Vijayaraghavan S, Joshi S, Fischer S, Reichert J, Barth JV. Five-vertex lanthanide coordination on surfaces: A route to sophisticated nanoarchitectures and tessellations. Journal of Physical Chemistry C [Internet]. 2014;118(24):12908 - 12915. Publisher's Version
Aad G, others. {Flavor tagged time-dependent angular analysis of the $B_s \rightarrow J/\psi \phi$ decay and extraction of $Δ\Gamma$s and the weak phase $\phi_s$ in ATLAS}. Phys. Rev. D. 2014;90:052007.
Theodossiadis G, Petrou P, Eleftheriadou M, Moustakas AL, Datseris I, Theodossiadis P. Focal vitreomacular traction: a prospective study of the evolution to macular hole: the mathematical approach. Eye. 2014;28(12):1452-1460.
Pitychoutis PM, Sanoudou D, Papandreou M, Nasias D, Kouskou M, Tomlinson CR, Tsonis PA, Papadopoulou-Daifoti Z. Forced swim test induces divergent global transcriptomic alterations in the hippocampus of high versus low novelty-seeker rats. Hum GenomicsHum GenomicsHum Genomics. 2014;8:4.Abstract
BACKGROUND: Many neuropsychiatric disorders, including stress-related mood disorders, are complex multi-parametric syndromes. Susceptibility to stress and depression is individually different. The best animal model of individual differences that can be used to study the neurobiology of affect regards spontaneous reactions to novelty. Experimentally, when naive rats are exposed to the stress of a novel environment, they display a highly variable exploratory activity and are classified as high or low responders (HR or LR, respectively). Importantly, HR and LR rats do not seem to exhibit a substantial differentiation in relation to their 'depressive-like' status in the forced swim test (FST), a widely used animal model of 'behavioral despair'. In the present study, we investigated whether FST exposure would be accompanied by phenotype-dependent differences in hippocampal gene expression in HR and LR rats. RESULTS: HR and LR rats present a distinct behavioral pattern in the pre-test session but develop comparable depressive-like status in the second FST session. At 24 h following the second FST session, HR and LR rats (stressed and unstressed controls) were sacrificed and hippocampal samples were independently analyzed on whole rat genome Illumina arrays. Functional analysis into pathways and networks was performed using Ingenuity Pathway Analysis (IPA) software. Notably, hippocampal gene expression signatures between HR and LR rats were markedly divergent, despite their comparable depressive-like status in the FST. These molecular differences are reflected in both the extent of transcriptional remodeling (number of significantly changed genes) and the types of molecular pathways affected following FST exposure. A markedly higher number of genes (i.e., 2.28-fold) were statistically significantly changed following FST in LR rats, as compared to their HR counterparts. Notably, genes associated with neurogenesis and synaptic plasticity were induced in the hippocampus of LR rats in response to FST, whereas in HR rats, FST induced pathways directly or indirectly associated with induction of apoptotic mechanisms. CONCLUSIONS: The markedly divergent gene expression signatures exposed herein support the notion that the hippocampus of HR and LR rats undergoes distinct transcriptional remodeling in response to the same stress regimen, thus yielding a different FST-related 'endophenotype', despite the seemingly similar depressive-like phenotype.
Evelpidou N, Karkani A, Pirazzoli P. Fossil shorelines at Corfu and surrounding islands deduced from erosion notches. The Holocene. 2014;24(II):1565-1572.Abstract
New geomorphological investigations along the coasts of Corfu, Othonoi, Paxoi, and Antipaxoi Islands allowed the identification of recent fossil shorelines.Former sea-level positions were deduced from sea-level indicators. A ‘modern’ tidal notch, submerged c. −20 cm, was observed in all studied islands.This notch is regarded to have been submerged by the global sea-level rise that occurred during the 19th and 20th centuries at a rate exceeding thepossibilities of intertidal bioerosion. Its presence provides evidence that no vertical tectonic movements occurred since its formation. On Corfu, impactsof ancient earthquakes have left some marks of emergence at about ≥ +130 ± 11, +110 ± 11, +65 ± 11, +40 ± 11, and +25 ± 11 cm, as well as marks ofsubmergence at about −40 to −50, −85 ± 11, −120 ± 11, and −180 ± 11 cm. The emergence of +130 ± 11 cm, previously dated at about 790–400 cal. BC, was detected through erosion notches at various sites in the western part of Corfu and appears to continue even more west, at Othonoi Island. Tidalnotches submerged at depths exceeding 0.4 m were observed in the northeastern part of the island and suggest the local occurrence of a sequence offour coseismic subsidences, with average vertical displacements of 40 cm, during at least the last few millennia. At Paxoi and Antipaxoi, Holocene verticalmovements seem to have been mainly of subsidence. At Paxoi, the ‘modern’ notch was found at about −20 to −30 cm, while four more submerged tidalnotches were distinguished at about −40 ± 11, −60 ± 11, −75 ± 11, and −90 ± 11 cm, while in Antipaxoi, three submerged tidal notches were distinguishedat about −60 ± 11, −75 ± 11, and −120 ± 11 cm.
Moser A. From Aktionsart to aspect: grammaticalization and subjectifica­tion in Greek. Acta Linguistica Hafniensia [Internet]. 2014;46(3):955-965. Publisher's VersionAbstract
This article proposes an analysis of the historical changes in the aspectual system of Greek as a process of grammaticalization and subjectification, thus challenging the traditional view of Greek verbal aspect as a stable and in fact extremely conservative category, possibly very close to that of Proto-Indo- European. Specifically, the claim put forward here is that the original tripartite morphological opposition (Aorist – Present – Perfect stems) expressed Aktionsart, i.e. lexical aspect, distinctions (punctuality/telicity– durativity/atelicity–state, respectively) while the modern binary morpho- logical opposition (Aorist–Present stems) expresses the purely aspectual perfective–imperfective opposition. Since Aktionsart is based on inherent features of the action/state denoted by the verb while aspect expresses the speaker’s point of view, this constitutes a shift from objectivity to subjectivity as well as a somewhat atypical grammaticalization process. Keywords: gradient; perfective; progressive; habitual; perfect 
Kosteletos G, Georgaki A. From Digital ‘Echos’ to virtual ‘ethos’: Ethical aspects of Music Technology. In: ICMC. ; 2014.Abstract
In the present paper we aim to examine MusicTechnology through the lens of the ethical issuestypically raised in the field of Philosophy of Technologyregarding technological practices other than musiccomposition, performance, reproduction and distribution.With this analysis we will try not only to highlightseveral ethical facts about the practice of developing andusing digital tools for music but also to stress on the factthat Music Technology can be a platform for vigorousphilosophical meditation.
59_from_digital_echos_to_virtual_ethos_ethical_aspects_of_musictechnology_kosteletosgeorgaki.pdf
Rodrigues AS, Kevrekidis PG, Carretero-González R, Cuevas-Maraver J, Frantzeskakis DJ, Palmero F. From nodeless clouds and vortices to gray ring solitons and symmetry-broken states in two-dimensional polariton condensates. Journal of Physics Condensed Matter [Internet]. 2014;26. Website
Jelonnek J, Albajar F, Alberti S, Avramidis K, Benin P, Bonicelli T, Cismondi F, Erckmann V, Gantenbein G, Hesch K, et al. From Series Production of Gyrotrons for W7-X Toward {EU}-1 {MW} Gyrotrons for {ITER}. {IEEE} Transactions on Plasma Science [Internet]. 2014;42:1135–1144. Website
Jelonnek J, Albajar F, Alberti S, Avramidis K, Benin P, Bonicelli T, Cismondi F, Erckmann V, Gantenbein G, Hesch K, et al. From series production of gyrotrons for W7-X toward EU-1 MW gyrotrons for ITER. IEEE Transactions on Plasma Science [Internet]. 2014;42:1135-1144. Website
Jelonnek J, Albajar F, Alberti S, Avramidis K, Benin P, Bonicelli T, Cismondi F, Erckmann V, Gantenbein G, Hesch K, et al. From series production of gyrotrons for W7-X toward EU-1 MW gyrotrons for ITER. IEEE Transactions on Plasma Science [Internet]. 2014;42:1135-1144. Website
Jelonnek J, Albajar F, Alberti S, Avramidis K, Benin P, Bonicelli T, Cismondi F, Erckmann V, Gantenbein G, Hesch K, et al. From series production of gyrotrons for W7-X toward EU-1 MW gyrotrons for ITER. IEEE Transactions on Plasma Science [Internet]. 2014;42:1135-1144. Website
Gast K, Finch CE, Crimmins EM, Beltrán-Sánchez H, Gschwind YJ, Bischoff-Ferrari HA, Bridenbaugh SA, Härdi I, Kressig RW, Tung JY, et al. Front & Back Matter. Gerontology. 2014;60.
The Frontier, the Dreamer and the Dream: Crane, Roth and the Urgencies of American Nationhood
Tsimpouki T. The Frontier, the Dreamer and the Dream: Crane, Roth and the Urgencies of American Nationhood. In: Philip Roth and World Literature: Transatlantic Perspectives and Uneasy Passages. Cambria Press; 2014. pp. 67-102. Publisher's VersionAbstract
Philip Roth is among the most critically acclaimed and widely read contemporary American writers. Considered as one of the masters of the art of the novel, he is also known for his engagement with and advocacy for the fiction of other writers. This important aspect of his work, although recognized by many critics, has consistently been ignored by others, until the very recent attribution of the 2013 PEN/Allen Foundation Literary Service Award. The award promotes an understanding of Roth as a highly literary and referential writer in continuation of a trend in criticism which, from the beginning of his career, has consistently attempted to read his fiction in dialogue with other fiction. Such a critical stance, however, stands in stark contrast to that which, traditionally, emphasizes Roth’s self-isolation from world literature. It is against this backdrop of critical discussion and in consonance with the former stance that the contributors to this collection seek to broaden an understanding of Roth’s fiction and to place him within both his national and international contexts of prior and contemporary writers. A book like this is long overdue because not many are aware of the numerous intersections between Philip Roth’s fiction and world literature. In highlighting these intersections and uneasy passages, this comparative approach offers an important contribution to Philip Roth studies as well as to comparative literary study in general. It builds on previous comparative scholarship on Philip Roth and seeks to broaden even further the crossings and concepts through which comparisons can be made and sustained. It covers new authors from world literature and extends analysis of previously studied authors. The fourteen chapters on this book summon Roth’s intertextual links to authors ranging from the anonymous writer of the medieval play Everyman, through Thoreau, Hawthorne, Crane, Ellison, Coover, and the New York intellectuals in the United States, to Swift, Chekhov, Svevo, Kafka, Schulz, Gombrowicz, Camus, and Klíma in Europe, and on to Coetzee in South Africa. The book does not deal with all the works in Roth’s canon, but it offers a selection of works representing the different stages of Roth’s development as a writer, from his much-discussed works in the 1970s Portnoy’s Complaint and The Professor of Desire, to his engagement with the literature of Central Europe in the 1970s and 1980s, to the great works of the 1990s Sabbath’s Theater and the American trilogy, on to the later works Everyman and Exit Ghost. In addition, the book also examines texts which seem to have received less critical attention, such as the political satire Our Gang, Roth’s conversation with Ivan Klíma published in Shop Talk, and the epilogue to Zuckerman Bound––The Prague Orgy––which is rarely studied for itself. The aim of this book is not to force Philip Roth into systematic alignment with other writers but rather to be sensitive to the ways in which he responds to his precursors and contemporaries. Philip Roth and World Literature: Transatlantic Perspectives and Uneasy Passages is the first book-length study to examine Philip Roth and his works in this context. Having adopted the transatlantic as a framework through which Roth’s body of work can be explored, the book expands the understanding of Roth’s connections with the literary canon from American literature to European and world literature. In this way, the book pushes the edges of the transatlantic further to highlight Roth’s sympathy for and resistance to powerful earlier and contemporary modes of writing on both sides of the Atlantic and beyond. Each section of the book locates aspects of Roth’s fiction in an expanded literary space that unsettles assumptions of his so-called parochialism. The book illustrates some of the various comparative perspectives from which Roth’s work may be viewed. It brings into a dialogue a number of voices on both sides of the Atlantic with the aim to show that, like Roth’s fiction itself, literary scholarship on him is not self-enclosed and unitary. Of particular interest are the chapters by those outside of the United States who bring different interpretative frameworks into the existing traditionally North American scholarly criticism on Roth. By offering new readings of both well-studied and lesser-studied works, sometimes in unexpected company, the book discloses the critical difference that comparative scholarship can affect. The uneasy passages the book opens will not exhaust the numerous intersections between Roth and the work of other writers. The book’s contribution is to place Roth’s fiction firmly in a larger transnational context. Far from insular, Roth’s work appears as deeply rooted in the American canon while at the same time showing a remarkable openness, a persistent need for contact with his European forebears, and true engagement with contemporary world literature. The transnational perspective of the book makes it important for the rapidly growing field of transatlantic and transnational American studies. The book will be value to collections in American literature and Jewish studies, comparative literature and criticism, and transatlantic and transnational American studies.  
Loupis M, Papanikolaou N, Prousalidis J. Fuel consumption reduction in marine power systems through thermoelectric energy recovery. In: 2nd International MARINELIVE Conference on All Electric Ship, Athens. ; 2014.
Loupis M, Papanikolaou N, Prousalidis J. Fuel consumption reduction in marine power systems through thermoelectric energy recovery. In: ; 2014.
Herweg NA, Weber B, Kasparbauer A, Meyhöfer I, Steffens M, Smyrnis N, Ettinger U. Functional magnetic resonance imaging of sensorimotor transformations in saccades and antisaccades. Neuroimage. 2014;102:848–860.
Galanis P. Fundamental principles of writing research articles. Archives of Hellenic Medicine/Arheia Ellenikes Iatrikes. 2014;31(1).
Galanis P. Fundamental principles of writing research articles. Archives of Hellenic Medicine/Arheia Ellenikes Iatrikes. 2014;31.
Vavouranakis G. Funerary pithoi in Bronze Age Crete: their introduction and significance at the threshold of Minoan palatial society. American Journal of Archaeology. 2014;118(2):197-222.
Zerefos CS, Tetsis P, Amiridis V, Zerefos CS, Luterbacher J, Eleftheratos K, Gerasopoulos E, Kazadzis S, Papayannis A. Further evidence of important environmental information content in red-to-green ratios as depicted in paintings by great masters. Atmos. Chem. Phys. [Internet]. 2014;14:2987-3015. Publisher's Version a21_acp_2014.pdf
Cantat-Gaudin T, Vallenari A, Zaggia S, Bragaglia A, Sordo R, Drew JE, Eisloeffel J, Farnhill HJ, Gonzalez-Solares E, Greimel R, et al. The Gaia-ESO Survey: Stellar content and elemental abundances in the massive cluster NGC 6705. [Internet]. 2014;569:A17. WebsiteAbstract
Context. Chemically inhomogeneous populations are observed in most globular clusters, but not in open clusters. Cluster mass seems to play a key role in the existence of multiple populations. Aims: Studying the chemical homogeneity of the most massive open clusters is needed to better understand the mechanism of their formation and determine the mass limit under which clusters cannot host multiple populations. Here we studied NGC 6705, which is a young and massive open cluster located towards the inner region of the Milky Way. This cluster is located inside the solar circle. This makes it an important tracer of the inner disk abundance gradient. Methods: This study makes use of BVI and ri photometry and comparisons with theoretical isochrones to derive the age of NGC 6705. We study the density profile of the cluster and the mass function to infer the cluster mass. Based on abundances of the chemical elements distributed in the first internal data release of the Gaia-ESO Survey, we study elemental ratios and the chemical homogeneity of the red clump stars. Radial velocities enable us to study the rotation and internal kinematics of the cluster. Results: The estimated ages range from 250 to 316 Myr, depending on the adopted stellar model. Luminosity profiles and mass functions show strong signs of mass segregation. We derive the mass of the cluster from its luminosity function and from the kinematics, finding values between 3700 M⊙ and 11 000 M⊙. After selecting the cluster members from their radial velocities, we obtain a metallicity of [Fe/H] = 0.10 ± 0.06 based on 21 candidate members. Moreover, NGC 6705 shows no sign of the typical correlations or anti-correlations between Al, Mg, Si, and Na, which are expected in multiple populations. This is consistent with our cluster mass estimate, which is lower than the required mass limit proposed in the literature to develop multiple populations. Based on the data obtained at ESO telescopes under programme 188.B-3002 (the public Gaia-ESO spectroscopic survey, PIs Gilmore and Randich) and on the archive data of the programme 083.D-0671.Full Table 2 is only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/569/A17
Vasiliadis I, Kolovou G, Kolovou V, Giannakopoulou V, Boutsikou M, Katsiki N, Papadopoulou E, Mavrogeni S, Sorontila K, Pantos C, et al. Gene polymorphisms and thyroid function in patients with heart failure. Endocrine. 2014;45:46–54.
Chemissany W, Papadimitriou I. Generalized dilatation operator method for non-relativistic holography. Phys. Lett. B. 2014;737:272–276.
Karalis V, Macheras P, Bialer M. Generic Products of Antiepileptic Drugs: A Perspective on Bioequivalence, Bioavailability, and Formulation Switches Using Monte Carlo Simulations. CNS DRUGS. 2014;28:69-77.Abstract
Introduction Generic products of antiepileptic drugs (AEDs) are currently a controversial topic as neurologists and patients are reluctant to switch from brand products to generics and to switch between generics. Objective The aim of this study was to provide enlightenment on issues of bioequivalence (BE) and interchangeability of AED products. Methods Monte Carlo simulations of the classic 2 x 2 BE studies were performed to study the effect of sample size, within-subject variability, and the true difference in pharmacokinetic values of the products under comparison on BE acceptance of generic AED products. Simulations were extended to study the comparative performance of two generic AED products against the same innovative product. The simulated results are compared with literature data on AEDs. Results The question with regard to bioavailability (BA) is whether two formulations are different, while for BE the question is whether two formulations are sufficiently similar in terms of extent and rate of absorption. Therefore, the criteria for BA and BE and the statistical analysis involved in their analysis are different. Two generic formulations that meet regulatory approval requirements for generics by being bioequivalent to the same innovative AED may not be bioequivalent to one another and therefore should not be regarded as equal or as therapeutically equivalent products. A switch from a standard or an immediate-release formulation to a modified-release product, which comprises extended-release or delayed-release formulations, should not be regarded as a switch between generics, but rather as a switch between different formulation types. Discussions Switches between bioequivalent generic AED products could potentially lead to larger changes in plasma levels and exposure than the brand-to-generic switch. The simulation work verified the clinical findings that not all generic AED products bioequivalent to the same innovative product are bioequivalent to one another. Conclusions Two generic formulations that meet regulatory approval requirements for generics, by being bioequivalent to the innovative AED, may not be bioequivalent to one another. Additional BE criteria are needed for a formulation switch, particularly in epilepsy, where a breakthrough seizure may change a patient's status from seizure-free to refractory.
Vlachou E. Gennaro Chierchia,Logic in grammar: polarity, free choice and intervention (2013, Oxford University Press). Linguist List [Internet]. 2014. Publisher's Version
Purrington KS, Slager S, Eccles D, Yannoukakos D, Fasching PA, Miron P, Carpenter J, Chang-claude J, Martin NG, Montgomery GW, et al. Genome-wide association study identifies 25 known breast cancer susceptibility loci as risk factors for triple-negative breast cancer. Carcinogenesis [Internet]. 2014;35(5):1012 - 1019. WebsiteAbstract
Triple-negative (TN) breast cancer is an aggressive subtype of breast cancer associated with a unique set of epidemiologic and genetic risk factors. We conducted a two-stage genome-wide association study of TN breast cancer (stage 1: 1529 TN cases, 3399 controls; stage 2: 2148 cases, 1309 controls) to identify loci that influence TN breast cancer risk. Variants in the 19p13.1 and PTHLH loci showed genome-wide significant associations (P < 5 × 10-8) in stage 1 and 2 combined. Results also suggested a substantial enrichment of significantly associated variants among the single nucleotide polymorphisms (SNPs) analyzed in stage 2. Variants from 25 of 74 known breast cancer susceptibility loci were also associated with risk of TN breast cancer (P < 0.05). Associations with TN breast cancer were confirmed for 10 loci (LGR6, MDM4, CASP8, 2q35, 2p24.1, TERT-rs10069690, ESR1, TOX3, 19p13.1, RALY), and we identified associations with TN breast cancer for 15 additional breast cancer loci (P < 0.05: PEX14, 2q24.1, 2q31.1, ADAM29, EBF1, TCF7L2, 11q13.1, 11q24.3, 12p13.1, PTHLH, NTN4, 12q24, BRCA2, RAD51L1-rs2588809, MKL1). Further, two SNPs independent of previously reported signals in ESR1 [rs12525163 odds ratio (OR) = 1.15, P = 4.9 × 10-4] and 19p13.1 (rs1864112 OR = 0.84, P = 1.8 × 10-9) were associated with TN breast cancer. A polygenic risk score (PRS) for TN breast cancer based on known breast cancer risk variants showed a 4-fold difference in risk between the highest and lowest PRS quintiles (OR = 4.03, 95% confidence interval 3.46-4.70, P = 4.8 × 10-69). This translates to an absolute risk for TN breast cancer ranging from 0.8% to 3.4%, suggesting that genetic variation may be used for TN breast cancer risk prediction.
Brazitikos S, Giannopoulos A, Valettas P, Vritsiou B-H. Geometry of Isotropic Convex Bodies. Providence - RI: Mathematical Surveys and Monographs, 196. American Mathematical Society; 2014 pp. xx+594. Publisher's Version
Alexopoulos JD, Dilalos S, Vassilakis E, Michelioudakis D, Mavroulis S, Farangitakis P. A geophysical insight for the occurrence of Mediterranean temporary ponds, on Mts. Oiti and Kallidromo (Greece). In: 20th European Meeting of Environmental and Engineering Geophysics. Athens; 2014. Publisher's VersionAbstract
A geophysical survey was performed at selected locations of Mt. Oiti and Mt. Kallidromon characterized by the hosting of priority habits of Mediterranean temporary ponds and the threatened plant species of Veronica oetaea, in order to understand the geoenvironment and contribute to the conservation of biodiversity. Primarily, the formation of these seasonal ponds, where Veronica oetaea occurs, seems to depend exclusively on the local hydrogeological regime. Thus, we investigated the subsurface structure of “Livadies” and “Nevropolis” ponds with the application of Electrical Resistivity Tomography for high accuracy information and Vertical Electrical Sounding for deeper data acquisition. Four ERT sections and 15 geoelectrical soundings in total were carried out. The combined results of their processing revealed differences at the geological structure beneath the ponds locations. At “Livadies” pond (Mt. Oiti), two geoelectrical layers were distinguished both corresponding to a folded flysch succession, contributing to the formation of this pond. On the contrary, at “Nevropolis” pond two geoelectrical layers were identified and interpreted as a surficial soil deposit stratum covering the geomorphological karst structure of a polje, created on the underlying limestones. The combined geophysical research offered significant data for the formation and the hydrogeological status of the priority habitats.
Alexopoulos JD, Dilalos S, Vassilakis E, Michelioudakis D, Mavroulis S, Farangitakis P. A geophysical insight for the occurrence of Mediterranean temporary ponds, on Mts. Oiti and Kallidromo (Greece). In: 20th European Meeting of Environmental and Engineering Geophysics. Athens; 2014. pdf
Demoly P, Tanno LK, Akdis CA, Lau S, Calderon MA, Santos AF, Sanchez-Borges M, Rosenwasser LJ, Pawankar R, Papadopoulos NG. Global classification and coding of hypersensitivity diseases - An EAACI - WAO survey, strategic paper and review. Allergy. 2014;69(5):559-70.Abstract
Hypersensitivity diseases are not adequately coded in the International Coding of Diseases (ICD)-10 resulting in misclassification, leading to low visibility of these conditions and general accuracy of official statistics. To call attention to the inadequacy of the ICD-10 in relation to allergic and hypersensitivity diseases and to contribute to improvements to be made in the forthcoming revision of ICD, a web-based global survey of healthcare professionals' attitudes toward allergic disorders classification was proposed to the members of European Academy of Allergy and Clinical Immunology (EAACI) (individuals) and World Allergy Organization (WAO) (representative responding on behalf of the national society), launched via internet and circulated for 6 week. As a result, we had 612 members of 144 countries from all six World Health Organization (WHO) global regions who answered the survey. ICD-10 is the most used classification worldwide, but it was not considered appropriate in clinical practice by the majority of participants. The majority indicated the EAACI-WAO classification as being easier and more accurate in the daily practice. They saw the need for a diagnostic system useful for nonallergists and endorsed the possibility of a global, cross-culturally applicable classification system of allergic disorders. This first and most broadly international survey ever conducted of health professionals' attitudes toward allergic disorders classification supports the need to update the current classifications of allergic diseases and can be useful to the WHO in improving the clinical utility of the classification and its global acceptability for the revised ICD-11.
Molou E, Schulpis KH, Thodi G, Georgiou V, Dotsikas Y, Papadopoulos K, Biti S, Loukas YL. Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency in Greek newborns: The Mediterranean C563T mutation screening. Scandinavian Journal of Clinical and Laboratory Investigation [Internet]. 2014;74(3):259 - 263. Website
Protopapa F, Siettos CI, Evdokimidis I, Smyrnis N. Granger causality analysis reveals distinct spatio-temporal connectivity patterns in motor and perceptual visuo-spatial working memory. Frontiers in computational neuroscience. 2014;8:146.
Spanaki IE, Venetsanou F, Evaggelinou C, Skordilis EK. Graphomotor skills of Greek kindergarten and elementary school children: effect of a fine motor intervention program. Innovative Teaching. 2014;3(2).
Gazeas K, Sapountzis K. GRB 140423A: optical observations. [Internet]. 2014;16171:1. Website
Syrengelas D, Kalampoki V, Kleisiouni P, Konstantinou D, Siahanidou T. Gross motor development in full-term Greek infants assessed by the Alberta Infant Motor Scale: Reference values and socioeconomic impact. Early Hum Dev. 2014;90:353-7.Abstract
OBJECTIVE: The aims of this study were to investigate gross motor development in Greek infants and establish AIMS percentile curves and to examine possible association of AIMS scores with socioeconomic parameters. METHODS: Mean AIMS scores of 1068 healthy Greek full-term infants were compared at monthly age level with the respective mean scores of the Canadian normative sample. In a subgroup of 345 study participants, parents provided, via interview, information about family socioeconomic status. Multiple linear regression analysis was performed to evaluate the relationship of infant motor development with socioeconomic parameters. RESULTS: Mean AIMS scores did not differ significantly between Greek and Canadian infants in any of the 19 monthly levels of age. In multiple linear regression analysis, the educational level of the mother and also whether the infant was being raised by grandparents/babysitter were significantly associated with gross motor development (p=0.02 and p<0.001, respectively), whereas there was no significant correlation of mean AIMS scores with gender, birth order, maternal age, paternal educational level and family monthly income. CONCLUSIONS: Gross motor development of healthy Greek full-term infants, assessed by AIMS during the first 19months of age, follows a similar course to that of the original Canadian sample. Specific socioeconomic factors are associated with the infants’ motor development.
Matiatos J, Paraskevopoulou V, Dassenakis M, Alexopoulos J, Panagopoulos A, Lazogiannis K, Poulos S, Arampatzis G, Ghionis G, Kotsopoulos S, et al. Groundwater flow regime and quality assessment of the alluvial aquifer in the deltaic environment of river Pinios (Thessaly). In: 10th International Hydrogeological Congress of Greece. Vol. 1. ; 2014. pp. 437-446. Publisher's VersionAbstract
This study aims at defining the groundwater flow regime and the principal hydro-geochemical processes controlling groundwater quality in the deltaic plain of River Pinios (ThessalyGreece) and investigating whether seawater intrusion and pollution are influencing groundwater quality. Groundwater level monitoring from October 2012 to September 2013 shows that groundwater flow is seawards and that the water table of the phreatic aquifer is mainly declining during the summer period when it is over-pumping and natural recharge limited. Major ions analysed in 49 groundwater samples reveal that groundwater is mainly affected by four factors: (i) dissolution of calcite and dolomite; (ii) weathering of silicate minerals; (iii) seawater intrusion; and (iv) contaminant enrichment (e.g., NH4) mainly caused by point sources of pollution. High enrichment of Na and Cl near the coast gives an indication of seawater intrusion into the aquifer as also supported from the Na–Cl signature on the Piper diagram and the Revelle coefficient. The dissolution of calcite and dolomite results in Ca–HCO3 and Mg–HCO3 groundwater types, whereas natural geochemical processes are considered responsible for the aquifer's enrichment in minor elements (e.g., Fe, Mn). Based on the simulation results performed using PHREEQC model, groundwater is mainly supersaturated with respect to calcite and dolomite minerals, supporting a long residence time hypothesis. The relation between seasonal water level fluctuation and hydrochemistry shows that both are mainly controlled by the aquifer's recharge process.
Thomakos N, Zacharakis D, Rodolakis A, Zagouri F, Papadimitriou CA, Bamias A, Dimopoulos M-A, Haidopoulos D, Vlahos G, Antsaklis A. Gynecologic oncology patients in the surgical high dependency unit: An analysis of indications. Archives of Gynecology and Obstetrics [Internet]. 2014;290(2):335 - 339. WebsiteAbstract
Purpose: The establishment of high dependency units (HDUs) has been an undoubted advance in the management of patients undergoing major oncological procedures. The aim of this study was to examine the impact of various preoperative and perioperative patients' characteristics on the prolonged HDU stay. Methods: We conducted a retrospective study including all gynecologic oncology patients who underwent surgical management and were admitted postoperatively to our hospitals' HDU from 2006 to 2010. Results: A total of 1,014 patients were transferred to the HDU and divided into two groups according to the length of HDU stay. Group A consisted of 840 (82.8 %) patients who stayed in the HDU for ≤24 h and Group B included 174 (17.2 %) patients who remained in the HDU under close observation for >24 h. Older age was the only preoperative characteristic that remained significantly associated with HDU prolonged stay. In addition, three intraoperative factors such as use of invasive hemodynamic monitoring, bowel resection and estimated blood loss were proved to be independently associated with prolonged HDU stay. Conclusion: Certain characteristics could identify those patients who are more likely to benefit most from HDU admission. © 2014 Springer-Verlag.
K$\alpha$$\tau$$\acute{\alpha}$$ąppa$o$ς$ E$\upsilon$$\sigma$$\tau$$\rho$$\acute{\alpha}$$\tau$$ıota$o$ς$. H $\varepsilon$$ν$$ν$o$ıota$o$łambda$o$\gamma$$ıota$$ąppa$$\acuteη$ o$ıota$$ąppa$o$łambda$o$\gamma$$\acuteıota}$$\alpha$ $ąppa$$\alpha$$ıota$ $η$ $\alpha$$π$o$δ$o$\chi$$\acuteη$ $\tau$$η$$ς$ $þeta$$\varepsilon$$ømega$$\rho$$\acuteıot. 2014.
Papadaki C, Metzafou A, Ntoanidis L, Zogaris S, Evelpidou N, Argyropoulos D, Dimitriou E. Habitat hydraulic modeling for assessing changes of mesohabitat types of a Greek mountainous river. In: EGU. Austria; 2014.Abstract
The aim of this study is to describe and assess changes in physical attributes of mesohabitat types in response to different flows in a Greek mountainous river. Hydraulic simulations were applied using two one-dimensional hydraulic models, MIKE 11 and HEC-RAS. The differences between the two models were analyzed by comparing their outputs against in situ measurements. A 200 m reach in Acheloos river was chosen as study site (Mesochora upstream) mainly because it is located in relatively undisturbed conditions (near reference conditions according to the Water Framework Directive) but also because there is intense interest for the construction of small hydroelectric plants in this area and in other mountainous rivers. For the calibration process cross-sectional transects were established perpendicular to the river flow. Transects were typically placed in areas representative of the various habitat types, proportionally determined by a habitat mapping process at a larger stream segment. Each transect was permanently marked with metal rods to allow repeated measurements in time. A 2D topographic survey was conducted and field data (water level and velocity) were collected at the transects. Also, a gauging station was installed downstream of the reach in order to provide water level data in an hourly step. Hydraulic models were applied and calibrated over a range of flows and river stages using past measurements. For selecting the control transects a thorough analysis of various parameters, such as habitat representativity, streambed slope and substrate types, was applied. In this way the habitat changes were described based on various flow scenarios over time. In a later step the results from the hydraulic models will be combined with fish habitat simulation curves (HSCs) focusing on the integration of mesohabitat and microhabitat types in the environmental flow assessment scheme.
Papadaki C, Ntoanidis L, Zogaris S, Martinez-Capel F, R. M-M, Evelpidou N, Dimitriou E. Habitat hydraulic modeling for environmental flow restoration in upland streams in Greece. 12th International Conference "Protection & Restoration of the Environment", 29 June-3 July. 2014:385-392.Abstract
The aim of this study is to apply a state-of-the-art methodology for the estimation of environmental flows by predicting how different in-stream flows affect fish microhabitats. A habitat modelling approach was adopted to simulate and assess the ecological effects of physical aquatic habitat changes in Greek upland rivers downstream of water abstraction schemes (dams, river diversions, etc), since there is an intense debate about the construction of small hydroelectric plants in montane rivers. Two sites on the Acheloos river were chosen as study areas (Tripotamo and Mesochora upstream of the Mesochora dam), because they are located in relatively undisturbed conditions. Standard hydraulic simulation and aquatic habitat modelling was based on data surveyed along cross-sectional transects in a representative river reach. After field data collection a hydraulic model (HEC- RAS) was applied for different flows. The representative reach comprised of the habitat types and approximated proportions detected in a previous exploratory charting of hydromorphological units over a longer piece of river. Thus, a river segment for hydraulic modelling was identified in each of the study sites (segments with relatively homogeneous conditions in terms of hydrology, geomorphology, and habitats). The basic scheme of the physical habitat simulation was applied, based on a 1-dimentional hydraulic modelling, habitat evaluation with Habitat Suitability Curves (hereafter HSC) and generation of Weighted Usable Curves in function of river flow. This way, the habitat changes can be estimated for various stream flow conditions based on an indicator of habitat quantity and quality. Generic habitat suitability curves are used from Brown Trout, a relative of the native Balkan Brook Trout inhabiting local streams. In a later stage, several river flows will be integrated in the model calibration, in order to reduce the uncertainty of the model and simulate the habitat changes in terms of habitat time series within an ample range of river flows. The habitat evaluation was based on HSC; such curves are ecological models in a simple univariate format, indicating the habitat suitability of certain hydraulic conditions for a given fish species and life stage. The HSC are frequently defined by scientific studies, for the variables depth, mean velocity, substrate and cover (obtained by field observation using visual assessments by snorkelling). The habitat modelling in representative reaches enables an ecological assessment and the proposal of environmental flow regimes in the segments affected by a given water abstraction scheme. Finally, this preliminary application promotes the need for further science-based eco-hydrological approaches that are relevant to both biological quality elements and current EU policy.
Petropoulou M, Dimitrakoudis S, Mastichiadis A, Giannios D. Hadronic supercriticality as a trigger for γ-ray burst emission. [Internet]. 2014;444. WebsiteAbstract
We explore a one-zone hadronic model that may be able to reproduce γ-ray burst (GRB) prompt emission with a minimum of free parameters. Assuming only that GRBs are efficient high-energy proton accelerators and without the presence of an ab initio photon field, we investigate the conditions under which the system becomes supercritical, i.e. there is a fast, non-linear transfer of energy from protons to secondary particles initiated by the spontaneous quenching of proton-produced γ-rays. We first show analytically that the transition to supercriticality occurs whenever the proton injection compactness exceeds a critical value, which favours high proton injection luminosities and a wide range of bulk Lorentz factors. The properties of supercriticality are then studied with a time-dependent numerical code that solves concurrently the coupled equations of proton, photon, electron, neutron and neutrino distributions. For conditions that drive the system deep into the supercriticality, we find that the photon spectra obtain a Band-like shape due to Comptonization by cooled pairs and that the energy transfer efficiency from protons to γ-rays and neutrinos is high reaching ∼0.3. Although some questions concerning its full adaptability to the GRB prompt emission remain open, supercriticality is found to be a promising process in that regard.
Petropoulou M, Dimitrakoudis S, Mastichiadis A, Giannios D. Hadronic supercriticality as a trigger for γ-ray burst emission. [Internet]. 2014;444:2186 - 2199. WebsiteAbstract
We explore a one-zone hadronic model that may be able to reproduce γ-ray burst (GRB) prompt emission with a minimum of free parameters. Assuming only that GRBs are efficient high-energy proton accelerators and without the presence of an ab initio photon field, we investigate the conditions under which the system becomes supercritical, i.e. there is a fast, non-linear transfer of energy from protons to secondary particles initiated by the spontaneous quenching of proton-produced γ-rays. We first show analytically that the transition to supercriticality occurs whenever the proton injection compactness exceeds a critical value, which favours high proton injection luminosities and a wide range of bulk Lorentz factors. The properties of supercriticality are then studied with a time-dependent numerical code that solves concurrently the coupled equations of proton, photon, electron, neutron and neutrino distributions. For conditions that drive the system deep into the supercriticality, we find that the photon spectra obtain a Band-like shape due to Comptonization by cooled pairs and that the energy transfer efficiency from protons to γ-rays and neutrinos is high reaching ∼0.3. Although some questions concerning its full adaptability to the GRB prompt emission remain open, supercriticality is found to be a promising process in that regard.
Andreopoulou A. Head-related transfer function database matching based on sparse impulse response measurements. 2014.
Hatzistilli H, Zissimopoulou O, Galanis P, Siskou O, Prezerakos P, Zissimopoulos A, Kaitelidou D. Health professionals’ knowledge and attitude towards the umbilical cord blood donation in Greece. Hippokratia. 2014;18:110.
Hatzistilli H, Zissimopoulou O, Galanis P, Siskou O, Prezerakos P, Zissimopoulos A, Kaitelidou D. Health professionals’ knowledge and attitude towards the umbilical cord blood donation in Greece. Hippokratia. 2014;18(2):110.
Ponirou P, Diomidous M, Kalokairinou A, Mantas J, Tsimahidou C, Tzavara C. Health Related Quality of Life in a Sample of Older People who are Members of Open Care Centers for the Elderly. Stud Health Technol Inform. 2014;202:269-72.Abstract
The consequences of demographic ageing, demographic and social-economic changes, changes in the structure of family, in the shrinkage of Welfare state, influenced the lifestyle of the older people and their social relations. The institution of Open Care Centers for the Elderly (KAPI) was created in the context of these conditions. This cross-sectional study examined the lifestyle of the older people who are member of KAPI and their association with all HRQoL dimensions. The results of this research showed that the main reason for the participants to become members of the KAPI was entertainment and/or companionship (98.4%). Additionally subjects who suffered from a chronic disease had significantly lower scores on all HRQoL dimensions, while participants who were members in the activity groups of KAPI had significantly higher scores. The elderly within the KAPI have many opportunities to meet with other persons of their age, and develop various activities and interests.
Vardiampasis V, Tsironi M, Nikolentzo A, Moisoglou I, Galanis P, Stavropoulou H, Athanasopoulou G, Prezerakos P. Health services staffing with physicians in the remote areas: Recruitment and retention incentives. Archives of Hellenic Medicine/Arheia Ellenikes Iatrikes. 2014;31(1).
Vardiampasis V, Tsironi M, Nikolentzo A, Moisoglou I, Galanis P, Stavropoulou H, Athanasopoulou G, Prezerakos P. Health services staffing with physicians in the remote areas: Recruitment and retention incentives. Archives of Hellenic Medicine/Arheia Ellenikes Iatrikes. 2014;31.
Zhu CW, Scarmeas N, Ornstein K, Albert M, Brandt J, Blacker D, Sano M, Stern Y. Health-care use and cost in dementia caregivers: Longitudinal results from the Predictors Caregiver Study. Alzheimers Dement. 2014.Abstract
OBJECTIVE: To examine the effects of caregiver and patient characteristics on caregivers' medical care use and cost. METHODS: One hundred forty-seven caregiver/patient dyads were followed annually for 6 years in three academic Alzheimer's disease centers in the United States. Logistic, negative binomial, and generalized linear mixed models were used to examine overall effects of caregiver/patient characteristics on caregivers' hospitalizations, doctor visits, outpatient tests and procedures, and prescription and over-the-counter medications. RESULTS: Patients' comorbid conditions and dependence were associated with increased health-care use and costs of caregivers. Increases in caregiver depressive symptoms are associated with increases in multiple domains of caregivers' health-care use and costs. DISCUSSION: Findings suggest expanding our focus on dementia patients to include family caregivers to obtain a fuller picture of effects of caregiving. Primary care providers should integrate caregivers' needs in health-care planning and delivery. Clinical interventions that treat patients and caregivers as a whole will likely achieve the greatest beneficial effects.
Stergiannis P, Katsoulas T, Fildissis G, Intas G, Galanis P, Kosta N, Zidianakis V, Baltopoulos G. Health-related quality of life and rehabilitation cost following intensive care unit stay in multiple trauma patients. Journal of Trauma Nursing| JTN. 2014;21:115–121.
Stergiannis P, Katsoulas T, Fildissis G, Intas G, Galanis P, Kosta N, Zidianakis V, Baltopoulos G. Health-related quality of life and rehabilitation cost following intensive care unit stay in multiple trauma patients. Journal of Trauma Nursing| JTN. 2014;21(3):115-121.
Goossens NJ, Flokstra-de Blok BMJ, van der Meulen GN, Arnlind MH, Asero R, Barreales L, Burney P, Cerecedo I, Clausen M, Fernandéz-Rivas M, et al. Health-related quality of life in food-allergic adults from eight European countries. Ann Allergy Asthma Immunol. 2014;113(1):63-68.e1.Abstract
BACKGROUND: Food allergy can impair health-related quality of life (HRQL). Food Allergy Quality of Life Questionnaires (FAQLQs) have been developed and validated, including an adult form (FAQLQ-AF). HRQL has not, to date, been measured across different European countries using a uniform methodology. OBJECTIVE: To translate and validate the FAQLQ-AF for use in 8 European countries (Iceland, The Netherlands, Poland, France, Spain, Italy, Greece, and Sweden). METHODS: The English FAQLQ-AF was translated, back-translated, and compared for use in the 8 relevant European languages. Adults with a perceived food allergy were recruited from outpatient departments and through a community survey. Participants completed the FAQLQ-AF, the Food Allergy Independent Measure, and questions concerning participants' characteristics. Validity of the FAQLQ-AF was analyzed for use in the 8 countries. RESULTS: The FAQLQ-AF had strong construct validity (r > 0.59) and an excellent internal consistency (Cronbach α > 0.95) in all countries. Total FAQLQ-AF scores (range 3.2-5.0) were significantly different across participating countries. CONCLUSION: The FAQLQ-AF is a suitable and valid instrument for measuring HRQL in food-allergic adults in Iceland, The Netherlands, Poland, France, Spain, Italy, Greece, and Sweden. The impact of food allergy on HRQL seems to differ among adults from the 8 participating European countries.
Vogel T, Kitcharoensakkul M, Fotis L, Baszis K. The heart and pediatric rheumatology. Rheumatic Disease Clinics. 2014;40(1):61-85.
Moustris KP, Kavadias K, Nastos PT, Larissi IK, Paliatsos AG. HEAT STRESS CONDITIONS IN THE GREEK TERRITORY WITHIN THE WARM PERIOD OF THE YEAR. FRESENIUS ENVIRONMENTAL BULLETIN. 2014;23:3068–3076.
Dasyra KM, Combes F, Novak GS, Bremer M, Spinoglio L, Santaella PM, Salomé P, Falgarone E. Heating of the molecular gas in the massive outflow of the local ultraluminous-infrared and radio-loud galaxy 4C12. 50. Astronomy & Astrophysics. 2014;565:A46.
Dardiotis E, Kosmidis MH, Yannakoulia M, Hadjigeorgiou GM, Scarmeas N. The Hellenic Longitudinal Investigation of Aging and Diet (HELIAD): Rationale, Study Design, and Cohort Description. Neuroepidemiology. 2014;43(1):9-14.Abstract
Background: Accumulating epidemiological evidence from several populations supports the important role of the Mediterranean-type diet (MeDi) in reducing the risk for age-related diseases such as Alzheimer's disease (AD). However, the relevant literature is clearly deficient for most Mediterranean countries that more closely adhere to the originally described MeDi. Greece resides in the Mediterranean basin, and older generations traditionally adhere to a MeDi. Methods: We here present the design and the preliminary baseline characteristics of the Hellenic Longitudinal Investigation of Aging and Diet (HELIAD). The HELIAD is a population-based, multidisciplinary, collaborative study designed to estimate the prevalence and incidence of AD, other dementias, mild cognitive impairment, and other neuropsychiatric conditions of aging in the Greek population and to investigate associations between nutrition and cognitive dysfunction/age-related neuropsychiatric diseases in this Mediterranean population. The study also ascertains several demographic, medical, social, environmental, clinical, nutritional, and neuropsychological determinants and lifestyle activities. Results: In total, 1,050 participants of a random sample have already completed the initial evaluation. The subjects were, on average, 73.4 (SD = 6.0) years old, 60% of the sample were female, and most of the participants were poorly educated with an average of 5.41 (SD = 3.5) years of education. The performance on the neuropsychological tests was equivalent to the average scores of previous normative Greek samples. More than one third of the population under investigation was considered to be at high risk for malnutrition. Conclusions: The HELIAD may provide important data for expanding our knowledge regarding the prevalence, incidence, and risk factors of AD and several other neuropsychiatric diseases in the Mediterranean region. © 2014 S. Karger AG, Basel.
Gkotzamanidou M, Terpos E, Kastritis E, Dimopoulos MA. Hematologic response and stabilization of renal function in a patient with light chain deposition disease after lenalidomide treatment: A novel therapeutic approach?. Clinical Lymphoma, Myeloma and Leukemia [Internet]. 2014;14(5):e179 - e181. Website
Karakassi K. Hermann Broch oder die Romantik Karakassi K, Lindinger S, Mark M. Deutsche Romantik.Transformationen Und Transgressionen. 2014:169 - 180.
Georgantzinos SK, Giannopoulos GI, Spanos KN, Anifantis NK. A Heterogeneous Discrete Approach of Interfacial Effects on Multi-Scale Modelling of Carbon Nanotube and Graphene Based Composites. In: Modeling of Carbon Nanotubes, Graphene and their Composites. Springer, Cham; 2014. pp. 83-109.
Skarpetis MG, Koumboulis FN, Ntellis AS. A Heuristic Control Algorithm for Robust Internal Model Control with Arbitrary Reference Model. In: Informatics in Control, Automation and Robotics: 9th International Conference, ICINCO 2012 Rome, Italy, July 28-31, 2012 Revised Selected Papers. Springer International Publishing; 2014. pp. 67–81.
Baar A, Pahr S, Constantin C, Giavi S, Papadopoulos NG, Pelkonen AS, Mäkelä MJ, Scheiblhofer S, Thalhamer J, Weber M, et al. The high molecular weight glutenin subunit Bx7 allergen from wheat contains repetitive IgE epitopes. Allergy. 2014;69(10):1316-1323.Abstract
BACKGROUND: Wheat is one of the most common food allergen sources for children and adults. The aim of this study was to characterize new wheat allergens using an IgE discovery approach and to investigate their IgE epitopes. METHODS: A cDNA expression library representing the wheat transcriptome was constructed in phage lambda gt11 and screened with IgE antibodies from wheat food allergic patients. IgE-reactive cDNA clones coding for portions of high molecular weight (HMW) glutenin subunits were identified by sequence analysis of positive clones. IgE epitopes were characterized using recombinant fragments from the HMW Bx7 and synthetic peptides thereof for testing of allergic patients' sera and in basophil degranulation assays. RESULTS: We found that the major IgE-reactive areas of HMW glutenins are located in the repetitive regions of the protein and could show that two independent IgE-reactive fragments from HMW Bx7 contained repetitive IgE epitopes. CONCLUSIONS: Our results demonstrate that IgE antibodies from wheat food allergic patients can recognize repetitive epitopes in one of the important wheat food allergens. Recombinant HMW Bx7 may be included into the panel of allergens for component-resolved diagnosis of wheat food allergy.
Spiliopoulos S, Kassimis G, Hatzidakis A, Krokidis M. High on-treatment platelet reactivity in peripheral endovascular procedures. CardioVascular and Interventional Radiology [Internet]. 2014;37(3):559 - 571. Website
Spiliopoulos S, Kassimis G, Hatzidakis A, Krokidis M. High on-treatment platelet reactivity in peripheral endovascular procedures. CardioVascular and Interventional Radiology [Internet]. 2014;37:559-571. Website
Simmons R, Semenenko I, Tolpina M, Tereschenko R, Kotlik L, Zasyptka L, Murphy G, McKinney E, Copas A, Malyuta R, et al. High percentage of recent HIV infection leading to onward transmission in Odessa, Ukraine associated with young adults. AIDS and Behavior. 2014;18:411–418.
Panagopoulos P, Paraskevis D, Katsarolis I, Sypsa V, Detsika M, Protopapas K, Antoniadou A, Papadopoulos A, Petrikkos G, Hatzakis A. High prevalence of the UGT1A1*28 variant in HIV-infected individuals in Greece. Int J STD AIDSInt J STD AIDSInt J STD AIDS. 2014;25:860-5.Abstract
Hyperbilirubinaemia with or without jaundice is one of the side effects of atazanavir boosted with low-dose ritonavir (ATV/rit) related to the drug plasma levels, as a result of its metabolism by UGT1A1 - uridine diphosphate-glucuronosyl transferase. Genotyping for UGT1A1*28 before initiation of antiretroviral therapy containing atazanavir may aid in identifying individuals at risk of hyperbilirubinaemia. Our objective was to estimate the prevalence of the UGTA1A1*28 polymorphism in HIV-infected individuals in Greece and to determine its potential association with hyperbilirubinaemia in patients receiving ATV/rit. The prevalence of the UGTA1A1*28 variant was estimated in 79 HIV-infected patients prior to the administration of the first-line treatment. The UGTA1A1*28 variant was detected in 46 out of 79 individuals (58.2%). Antiretroviral therapy was administered to 64/79 patients (81%). Among them, 26/64 (40.6%) received ATV/rit. Of the ATV/rit-treated patients, 14 were found to be carriers of the UGT1A1*28 variant (54%), and maximum serum bilirubin levels were significantly higher in the carrier population (4.71 vs. 2.69 mg/dL, p = 0.026). In 50% of the population, maximum levels were recorded in the first month of follow-up. Although carriage of UGT1A1 is linked with the development of hyperbilirubinaemia, the implementation of a pharmacogenomic approach in clinical practice cannot yet be recommended as a standard of care.
Panagopoulos P, Paraskevis D, Katsarolis I, Sypsa V, Detsika M, Protopapas K, Antoniadou A, Papadopoulos A, Petrikkos G, Hatzakis A. High prevalence of the UGT1A1*28 variant in HIV-infected individuals in Greece. Int J STD AIDS. 2014;25(12):860-5.Abstract
Hyperbilirubinaemia with or without jaundice is one of the side effects of atazanavir boosted with low-dose ritonavir (ATV/rit) related to the drug plasma levels, as a result of its metabolism by UGT1A1 - uridine diphosphate-glucuronosyl transferase. Genotyping for UGT1A1*28 before initiation of antiretroviral therapy containing atazanavir may aid in identifying individuals at risk of hyperbilirubinaemia. Our objective was to estimate the prevalence of the UGTA1A1*28 polymorphism in HIV-infected individuals in Greece and to determine its potential association with hyperbilirubinaemia in patients receiving ATV/rit. The prevalence of the UGTA1A1*28 variant was estimated in 79 HIV-infected patients prior to the administration of the first-line treatment. The UGTA1A1*28 variant was detected in 46 out of 79 individuals (58.2%). Antiretroviral therapy was administered to 64/79 patients (81%). Among them, 26/64 (40.6%) received ATV/rit. Of the ATV/rit-treated patients, 14 were found to be carriers of the UGT1A1*28 variant (54%), and maximum serum bilirubin levels were significantly higher in the carrier population (4.71 vs. 2.69 mg/dL, p = 0.026). In 50% of the population, maximum levels were recorded in the first month of follow-up. Although carriage of UGT1A1 is linked with the development of hyperbilirubinaemia, the implementation of a pharmacogenomic approach in clinical practice cannot yet be recommended as a standard of care.
Higher Education Law. Athens: Nomiki Vivliothiki; 2014 pp. 520. Publisher's Version
Kouroutzoglou J, Flocas HA, Hatzaki M, Keay K, Simmonds I. A high-resolution climatological study on the comparison between surface explosive and ordinary cyclones in the Mediterranean. Regional Environmental Change [Internet]. 2014;14(5):1833 - 1846. Website
Kouroutzoglou J, Flocas HA, Hatzaki M, Keay K, Simmonds I. A high-resolution climatological study on the comparison between surface explosive and ordinary cyclones in the Mediterranean. Regional Environmental Change [Internet]. 2014;14:1833-1846. Website
Sakellariou S, Boletis JN, Sypsa V, Psichogiou M, Tiniakos D, Delladetsima I. Histological features of chronic hepatitis C in haemodialysis patients. Liver IntLiver IntLiver Int. 2014;34:e56-61.Abstract
BACKGROUND & AIMS: HCV infection in haemodialysis (HD) patients is still a matter of investigation. The aim of this study was to determine the histology of chronic hepatitis C (CHC) in HCV-infected HD patients within the context of a comparative analysis including non-uraemic patients with CHC. The relative importance of virological, demographic and clinical parameters on disease manifestation was examined. METHODS: Sixty-one consecutive liver biopsies from HD patients and 326 from non-uraemic patients with chronic HCV infection were comparatively evaluated. RESULTS: Haemodialysis patients with CHC were older than control subjects (P = 0.031), showing a similar HCV genotype distribution (P = 0.328) and lower viral load (P = 0.001). CHC in HD patients was significantly milder according to stage (P = 0.033), grade and its parameters (periportal activity, portal inflammation and lobular activity) (P < 0.001). The frequency of lymphoid aggregates (10.2% vs. 50%, P < 0.001), bile duct lesions (1.7% vs. 22.1%, P < 0.001) and extent of steatosis (P = 0.022) in HD group was significantly reduced. Multivariate analysis showed that non-uraemic patients had 2.3 times higher risk of developing steatosis independently of genotype distribution and age. In HD group, genotype 3, longer HD duration and age at infection were significantly associated with steatosis, while older age at infection correlated with advanced fibrosis. CONCLUSIONS: Chronic hepatitis C in HD patients is usually very mild, losing its diagnostic histological features while patient's age and age at infection retain their prognostic significance. The weak inflammatory response, probably because of immunocompromised status and low viral load, may present a beneficial factor in the natural course of the disease.
Alexandrakis G, Poulos SE. An holistic approach to beach erosion vulnerability assessment. Scientific Reports [Internet]. 2014;4. Website
Evelpidou N, Pirazzoli P. Holocene relative sea-level changes from submerged tidal notches: A methodological approach. Quaternaire. 2014;25 (4):383-390.Abstract
Underwater geomorphological survey may reveal evidence of submerged tidal notches. In this paper, we present the methodology with the aim to reveal past temporary standstills of relative sea-level. Some examples of tidal notch development and tectonic movements are provided from fossil submerged notches mainly from Greece. A vertical movement causes a displacement of the intertidal bioerosion zone. For this reason the tidal notch profile reflects changes that occurred in the relative sea-level. If the movement is rapid a new tidal notch will be formed. On the contrary, if the movement is slower than the intertidal bioerosion rate, the height of the notch will increase. For this reason underwater marks on carbonate cliffs may provide evidence of recent vertical shoreline displacements of gradual or co-seismic origin.
Androulidakis I, Zambon M. Holonomy transformations for singular foliations. Adv. Math. [Internet]. 2014;256:348–397. Publisher's VersionAbstract
In order to understand the linearization problem around a leaf of a singular foliation, we extend the familiar holonomy map from the case of regular foliations to the case of singular foliations. To this aim we introduce the notion of holonomy transformation. Unlike the regular case, holonomy transformations cannot be attached to classes of paths in the foliation, but rather to elements of the holonomy groupoid of the singular foliation.
az_holo07june2012.pdf
Koliopoulou M. How close to syntax are compounds? Evidence from the linking element in German and Modern Greek compounds. Rivista di Linguistica. 2014;26(2):51-70.
Ίντας Γεώργιος, Στεργιάννης Παντελής. How safe are the airbags?. 2014.
Fukushima T, Katayama-Yoshida H, Sato K, Bihlmayer G, Mavropoulos P, Bauer DSG, Zeller R, Dederichs PH. Hubbard U calculations for gap states in dilute magnetic semiconductors. JOURNAL OF PHYSICS-CONDENSED MATTER. 2014;26:274202.Abstract
On the basis of constrained density functional theory, we present ab initio calculations for the Hubbard U parameter of transition metal impurities in dilute magnetic semiconductors, choosing Mn in GaN as an example. The calculations are performed by two methods: (i) the Korringa-Kohn-Rostoker (KKR) Green function method for a single Mn impurity in GaN and (ii) the full-potential linearized augmented plane-wave (FLAPW) method for a large supercell of GaN with a single Mn impurity in each cell. By changing the occupancy of the majority t(2) gap state of Mn, we determine the U parameter either from the total energy differences E(N + 1) and E(N - 1) of the (N +/- 1) -electron excited states with respect to the ground state energy E(N), or by using the single-particle energies for n(0) +/- 1/2 occupancies around the charge-neutral occupancy n(0) (Janak's transition state model). The two methods give nearly identical results. Moreover the values calculated by the supercell method agree quite well with the Green function values. We point out an important difference between the `global' U parameter calculated using Janak's theorem and the `local' U of the Hubbard model.
Poulos SE, Ghionis G, Verykiou E, Roussakis G, Sakellariou D, Karditsa A, Alexandrakis G, Petrakis S, Sifnioti D, Panagiotopoulos IP, et al. Hydrodynamic, neotectonic and climatic control of the evolution of a barrier beach in the microtidal environment of the NE Ionian Sea (eastern Mediterranean). Geo-Marine Letters [Internet]. 2014;35:37-52. Website
Poulos SE, Ghionis G, Verykiou E, Roussakis G, Sakellariou D, Karditsa A, Alexandrakis G, Petrakis S, Sifnioti D, Panagiotopoulos IP, et al. {Hydrodynamic, neotectonic and climatic control of the evolution of a barrier beach in the microtidal environment of the NE Ionian Sea (eastern Mediterranean)}. Geo-Marine Letters [Internet]. 2014. Website
Fotis L, Vazeou A, Xatzipsalti M, Stamoyannou L. Hypotonic hyporesponsive episode and the 13-valent pneumococcal vaccine. The Turkish Journal of Pediatrics. 2014;56(4):427-429.
Anoussis M, Katavolos A, Todorov IG. Ideals of {$A(G)$} and bimodules over maximal abelian selfadjoint algebras. J. Funct. Anal. [Internet]. 2014;266:6473–6500. Website
Tsolkas I. Il messaggio “femminista” di mitiò Sakellariu. Revista Internacional de Culturas y Literaturas, 15. 2014.
Grase A, Zimmermann T, NG P, Vuorinen T, S F. IL-17A and its anti-viral properties in alergic asthma. Allergy. 2014;69:590.
Zagouri F, Kastritis E, Symeonidis AS, Giannakoulas N, Katodritou E, Delimpasi S, Repousis P, Terpos E, Dimopoulos MA. Immunoglobulin D myeloma: Clinical features and outcome in the era of novel agents. European Journal of Haematology [Internet]. 2014;92(4):308 - 312. WebsiteAbstract
Objectives: Immunoglobulin D (IgD) multiple myeloma is an uncommon variant of the disease probably associated with poorer prognosis. However, data on IgD myeloma patients treated in the novel agent era are lacking. Methods: To assess the frequency and the specific characteristics and evaluate the outcome of patients with IgD myeloma, we analyzed the database of the Greek Myeloma Study Group. Results: Between January 2000 and December 2012, among the 1239 patients with symptomatic myeloma, 31 (2.5%) were diagnosed with IgD myeloma. The median age of patients with IgD myeloma was 65 yr (range 26-80 yr) versus 68 yr (range 23-96 yr) of all others, and 84% had lambda light chain (vs. 38% of the patients with other subtypes). Patients with IgD myeloma presented more often with features of high-risk disease, that is, with advanced ISS, high LDH, significant renal dysfunction, and large amounts of Bence Jones proteinuria. Response to primary therapy was similar to other patients, although there was a trend for better quality of responses in patients with IgD myeloma. The median survival of these patients was 51.5 months versus 50.7 months for patients of other subtypes. In a multivariate model to adjust for differences in prognostic features, IgD myeloma was not associated with a different prognosis. Conclusion: The incidence of IgD myeloma is 2.5%. Although patients with IgD myeloma present more often with high-risk features, their outcome in the era of novel agents is similar to that of patients with other myeloma subtypes. © 2013 John Wiley & Sons A/S.
Eichhorn S, Pablos I, Laimer J, Jensen BM, Versteeg S, Lackner P, Zuidmeer-Jongejan L, Fernandez-Rivas M, Papadopoulos NG, Mari A, et al. Immunological characterization of a pru p3 proline variant for treatment of LTP-related peach allergy. 2014;69:1.
Kaitelidou D, Kalogeropoulou M, Galanis P, Theodorou M, Charalambous G, Liaropoulos L. Impact of Economic Crisis on the Greek Health Care System and on the Population Health. Value in Health. 2014;17(7):A446.
Kaitelidou D, Kalogeropoulou M, Galanis P, Theodorou M, Charalambous G, Liaropoulos L. Impact of Economic Crisis on the Greek Health Care System and on the Population Health. Value in Health. 2014;17:A446.
Rouvas AA, Chatziralli IP, Ladas ID, Xanthopoulou V, Giannakaki E, Karamboula A, Galanis D, Datseris I, Alonistiotis D, Diamanti R, et al. The impact of financial crisis on central serous chorioretinopathy in Greece: is there any correlation?. European journal of ophthalmology. 2014;24:559–565.
Theodoraki K, Markatou M, Rizos D, Fassoulaki A. The impact of two different transfusion strategies on patient immune response during major abdominal surgery: A preliminary report. Journal of Immunology Research. 2014;2014.Abstract
Blood transfusion is associated with well-known risks. We investigated the difference between a restrictive versus a liberal transfusion strategy on the immune response, as expressed by the production of inflammatory mediators, in patients subjected to major abdominal surgery procedures. Fifty-eight patients undergoing major abdominal surgery were randomized preoperatively to either a restrictive transfusion protocol or a liberal transfusion protocol (with transfusion if hemoglobin dropped below 7.7 g dL-1 or 9.9 g dL -1, respectively). In a subgroup of 20 patients randomly selected from the original allocation groups, blood was sampled for measurement of IL-6, IL-10, and TNFα. Postoperative levels of IL-10 were higher in the liberal transfusion group on the first postoperative day (49.82 ± 29.07 vs. 15.83 ± 13.22 pg mL-1, P < 0.05). Peak postoperative IL-10 levels correlated with the units of blood transfused as well as the mean duration of storage and the storage time of the oldest unit transfused (r 2 = 0.38, P = 0.032, r2 = 0.52, P = 0.007, and r 2 = 0.68, P < 0.001, respectively). IL-10 levels were elevated in patients with a more liberal red blood cell transfusion strategy. The strength of the association between anti-inflammatory IL-10 and transfusion variables indicates that IL-10 may be an important factor in transfusion-associated immunomodulation. This trial is registered under ClinicalTrials.gov Identifier: NCT02020525. © 2014 Kassiani Theodoraki et al.
Karavas E. Implementing innovation in primary EFL: A case study in Greece. ELT Journal Special Issue 2014 "Teaching English to Young Learners" [Internet]. 2014;68(3):243-253. Publisher's VersionAbstract
The purpose of this article is to highlight and discuss the strategies used to diffuse and manage a primary ELT innovation in Greece, strategies that proved essential for developing stakeholders’ acceptance and ownership of the innovation, thereby facilitating its further development and sustainability. The PEAP Programme, launched in 2010, involved the introduction of EFL in the first and second grades of public primary schools in Greece. The extent of its impact and acceptance by teachers and other stakeholders was unexpected given the fact that the project was developed and implemented within a context of social and political instability and massive public sector and economic reform. The strategies reported in this article have implications for the successful management and implementation of primary EFL innovations in Europe and elsewhere.
Vrachopoulos GM, Koukou MK, Tachos N, Kalognomos S, Adamidis A, Lavrenti F, Pappas J, Xygogianni P, Karytsas C. Implementing the GEOPEAK Project in Greece towards the achievement of Europe 20-‐20-‐20 targets: Development and Evaluation of a Geothermal Heat Pump of High Efficiency. 2014.
Petropoulou M, Giannios D, Dimitrakoudis S. Implications of a PeV neutrino spectral cut-off in gamma-ray burst models. [Internet]. 2014;445:570 - 580. WebsiteAbstract
The recent discovery of extragalactic PeV neutrinos opens a new window to the exploration of cosmic ray accelerators. The observed PeV neutrino flux is close to the Waxman-Bahcall upper bound implying that gamma-ray bursts (GRBs) may be the source of ultrahigh energy cosmic rays (UHECRs). Starting with the assumption of the GRB-UHECR connection, we show using both analytical estimates and numerical simulations that the observed neutrinos can originate at the jet as a result of photopion interactions with the following implications: the neutrino spectra are predicted to have a cut-off at energy ≲10 PeV; the dissipation responsible for the GRB emission and cosmic ray acceleration takes place at distances rdiss ≃ 3 × 1011-3 × 1013 cm from the central engine; the Thomson optical depth at the dissipation region is τT ∼ 1; the jet carries a substantial fraction of its energy in the form of Poynting flux at the dissipation region, and has a Lorentz factor Γ ≃ 100-500. The non-detection of PeV neutrinos coincident with GRBs will indicate that GRBs are either poor cosmic accelerators or the dissipation takes place at small optical depths in the jet.
Drikos S, Kountouris P. The importance of certain performance indicators on specific set types in Volleyball. Inquiries in Sport & Physical Education. [Internet]. 2014;12(1):17–25. Publisher's Version
Drikos S, Kountouris P. The Importance of Certain Performance Indicators on Specific Set Types in Volleyball. Inquiries in Sport & Physical Education [Internet]. 2014;12:17-25. WebsiteAbstract
The aim of this study was to identify volleyball performance indicators that best discriminate between winning and losing teams in a set according to set final score differences. The data were collected from teams’ performances (N=175) in all sets played during the 2009 Men’s European Volleyball Championship in Turkey. Clusters analysis established three different groups of sets according to set final score difference: 2 points (ambivalent), 3-5 points (safe), >5 points (unbalanced). A Wilcoxon signed rank test was performed on 10 performance indicators and 4 match indicators. The analysis revealed 11 important indicators for all sets have been played and for unbalanced set too, 7 important indicators for safe sets and 1 indicator for a m-bivalent sets. The analysis of ambivalent sets showed that the winning teams had a statistically significant (p <0.001) percentage of points from direct attack compared to the defeated teams. The resu lts confirm that coaches of men’s volleyball team should attach importance to improving offensive capacities of athletes
Antoniou NG, Davis NN, Diakonos FK, Collaboration NA49. Improved intermittency analysis of proton density fluctuations in NA49 ion collisions at 158 AGeV. Bravina L, Foka Y, Kabana S. 2ND INTERNATIONAL CONFERENCE ON NEW FRONTIERS IN PHYSICS. 2014;71(2nd International Conference on New Frontiers in Physics).
Moschos MM, Chatziralli IP, Stamatakis G, Papakonstantinou VD, Demopoulos CA. In vitro effects of vitamin supplements on platelet-activating factor and its metabolism in age-related macular degeneration. Cutaneous and ocular toxicology. 2014;33:235–241.
Alexandrou A, Dimitriou N, Levidou G, Griniatsos J, Sougioultzis S, Korkolopoulou P, Felekouras E, Pikoulis E, Diamantis T, Tsigris C, et al. The incidence of HPV infection in anal cancer patients in Greece. Acta Gastroenterol Belg. 2014;77:213-216.Abstract
Background and aim of the study : Although anal cancer represents a relatively uncommon malignancy, its incidence over the last five decades, has been reported as increased for both sexes, worldwide. Human papillomavirus (HPV) infection has been shown to be a major cause for its development. The aim of the present study is to report on clinical, epidemiological and virological data of squamous anal cancer in Greek patients. Patients and Method : Between January 2002 and December 2010, 11 Greek patients (6 females) who were diagnosed as suffering from squamous cell anal or perianal cancer, were treated in our Hospital. Formalin fixed paraffin embedded tissue samples, obtained at the time of the anal biopsy or surgery, were analyzed by PCR in order to identify the presence as well as the type of HPV infection. Results : Overall, the presence of HPV DNA was detected in 6 out of the 11 patients (54.5%). The “highrisk” HPV DNA was  detected in 3 of them (2 women and 1 man), while the “lowrisk” HPV DNA was detected in the remaining three (2 women and 1 man). Conclusion : The incidence of HPV infection in squamous cell anal cancer Greek patients, is lower than other Western countries, probably reflecting differences in sexual habits in the Greek  population
Chatziralli IP, Papazisis L, Sergentanis TN. Incomplete Gardner’s syndrome with blepharoptosis as the first symptom. International ophthalmology. 2014;34:301–303.
Kyritsis A, Papanikolaou N, Prousalidis J, Loupis M. Incorporating commercial inverters in the low voltage network of ships for energy saving applications. In: 2nd International MARINELIVE Conference on “All Electric Ship”. ; 2014.
Kyritsis A, Papanikolaou N, Prousalidis J, Loupis M. Incorporating commercial inverters in the low voltage network of ships for energy saving applications. In: ; 2014.
Papanikolaou N, Kyritsis A, Loupis M. Incorporating power converters for energy saving marine applications. In: 2014 International Conference on Electrical Machines (ICEM). IEEE; 2014. pp. 2306–2311.
Papanikolaou N, Kyritsis A, Loupis M. Incorporating power converters for energy saving marine applications. In: IEEE; 2014. pp. 2306 - 2311.
Asimakopoulou E-M, Madesis I, Dimitriou A, Zouros TJM, Mertzimekis TJ, Lagoyannis A, Axiotis M. Incorporation of an Ion Post Stripper for the APAPES Experimental Setup. In: Hellenic Nuclear Physics Society; 2014.
Frentz D, Van de Vijver DAMC, Abecasis AB, Albert J, Hamouda O, Jørgensen LB, Kücherer C, Struck D, Schmit J-C, Vercauteren J, et al. Increase in transmitted resistance to non-nucleoside reverse transcriptase inhibitors among newly diagnosed HIV-1 infections in Europe. BMC Infect Dis. 2014;14:407.Abstract
BACKGROUND: One out of ten newly diagnosed patients in Europe was infected with a virus carrying a drug resistant mutation. We analysed the patterns over time for transmitted drug resistance mutations (TDRM) using data from the European Spread program. METHODS: Clinical, epidemiological and virological data from 4317 patients newly diagnosed with HIV-1 infection between 2002 and 2007 were analysed. Patients were enrolled using a pre-defined sampling strategy. RESULTS: The overall prevalence of TDRM in this period was 8.9% (95% CI: 8.1-9.8). Interestingly, significant changes over time in TDRM caused by the different drug classes were found. Whereas nucleoside resistance mutations remained constant at 5%, a significant decline in protease inhibitors resistance mutations was observed, from 3.9% in 2002 to 1.6% in 2007 (p = 0.001). In contrast, resistance to non-nucleoside reverse transcriptase inhibitors (NNRTIs) doubled from 2.0% in 2002 to 4.1% in 2007 (p = 0.004) with 58% of viral strains carrying a K103N mutation. Phylogenetic analysis showed that these temporal changes could not be explained by large clusters of TDRM. CONCLUSION: During the years 2002 to 2007 transmitted resistance to NNRTI has doubled to 4% in Europe. The frequent use of NNRTI in first-line regimens and the clinical impact of NNRTI mutations warrants continued monitoring.
Foutadakis S, Avgeris M, Tokas T, Stravodimos K, Scorilas A. Increased BCL2L12 expression predicts the short-term relapse of patients with TaT1 bladder cancer following transurethral resection of bladder tumors. Urol Oncol. 2014;32:39 e29-36.Abstract
OBJECTIVES: More than half of the diagnosed patients with bladder cancer (BCa) recur at least once following their initial treatment. Thus, patients' monitoring and prognosis is of utmost importance. However, the need for intensive surveillance of BCa significantly burdens patients' health-related quality of life. The aim of the present study is the expression analysis of BCL2L12, a recently identified member of the BCL2 apoptosis-related gene family, in BCa and the evaluation of BCL2L12 prognostic significance for the survival outcome of the patients. METHODS AND MATERIALS: Our study included 115 patients with BCa, and tissue specimens were obtained from the tumor area as well as from adjacent normal bladder wall. BCL2L12 expression was determined using quantitative real-time polymerase chain reaction assay, and was further correlated with patients' clinicopathological features and follow-up survival data. RESULTS: Up-regulated BCL2L12 expression levels were detected in malignant bladder specimens compared with normal ones. The higher BCL2L12 expression was further associated with shorter disease-free survival of the patients with BCa. Focusing on patients with TaT1 non-muscle invasive BCa, BCL2L12 expression levels were correlated with higher recurrence rate at the first follow-up cystoscopy and were unveiled to be an independent unfavorable predictor of patients' short-term recurrence following transurethral resection. Finally, BCL2L12 expression levels were also associated with poor disease-free survival of the high-grade TaT1 patients. CONCLUSIONS: Our data highlight the unfavorable prognostic value of BCL2L12 for patients with BCa and support its potential clinical use for the assessment of TaT1 patients' recurrence risk.
Paparrigopoulos T, Melissaki A, Tzavellas E, Karaiskos D, Ilias I, Kokras N. Increased co-morbidity of depression and post-traumatic stress disorder symptoms and common risk factors in intensive care unit survivors: a two-year follow-up study. Int J Psychiatry Clin Practice. 2014;18:25-31.Abstract
OBJECTIVE: To investigate the long-term psychological impact of intensive care unit (ICU) hospitalization, as well as to establish risk factors which successfully discriminate patients at higher risk. METHODS: The Medical Outcomes Study Short Form Survey (SF-36), the Center for Epidemiologic Studies for Depression (CES-D), and the Davidson Trauma Scale (DTS) questionnaires were obtained from 48 ICU survivors who were also interviewed and self-reported on several acknowledged risk factors. RESULTS: A high co-morbidity between depression and post-traumatic stress disorder (PTSD) cases was observed. Both CES-D and DTS scores correlated negatively with the SF-36 mental health subscale scores; although a causative relation cannot be attributed to this finding, it indicates a potential negative impact of depression and PTSD symptoms on the patients' quality of life even at 18- to 24-month post-ICU. The most important risk factor associated with a long-term impact on quality of life, depression and PTSD was lifetime history of any psychiatric disorder. CONCLUSIONS: During ICU admissions efforts should be made towards identifying and psychologically supporting those patients with a previous history of a psychiatric disease, as they are at considerably higher risk of suffering from the long-term psychological sequelae of ICU admission.
Vontzalidis A, Terzis G, Manta P. Increased dysferlin expression in Duchenne muscular dystrophy. Anal Quant Cytopathol Histpathol. 2014;36(1):15-22.Abstract
OBJECTIVE: To investigate dysferlin expression in muscle biopsies from patients with Duchenne muscular dystrophy (DMD). Dysferlin is known to have a role in the process of membrane fusion and muscle membrane repair in skeletal muscle fibers. STUDY DESIGN: We analyzed 20 muscle biopsy samples of DMD patients with immunohistochemical techniques to determine the expression of dysferlin. Immunoblotting was performed to assess dysferlin abundance in dystrophic muscle. RESULTS: Dysferlin showed various immunostaining patterns in dystrophic muscle, including reduced, normal, or enhanced sarcolemmal expression and intracellular immunostaining of the protein. Immunoblotting revealed that dysferlin was upregulated in 15 out of the 20 samples (75%). The abundance of the protein was analogous to the number of fibers with enhanced sarcolemmal expression of the protein. CONCLUSION: These data suggest that although dysferlin is not an integral part of the dystrophin-glycoprotein complex, its expression is altered in Duchenne muscular dystrophy.
Karantinos T, Tsoukas E, Mantas A, Kattoulas E, Stefanis NC, Evdokimidis I, Smyrnis N. Increased intra-subject reaction time variability in the volitional control of movement in schizophrenia. Psychiatry research. 2014;215:26–32.
Alexe-Ionescu AL, Barbero G, Lelidis I. Independence of the effective dielectric constant of an electrolytic solution on the ionic distribution in the linear Poisson-Nernst-Planck model. Journal of Chemical Physics [Internet]. 2014;141:084505. Publisher's Version
Guibas G, Manios Y, Moschonis G, Xepapadaki P, Roumpedaki E, Lambrinou C, Papadopoulos NG. Infantile growth velocity and later asthma/wheeze: GENESIS and the Healthy Growth Study. European Respiratory Journal. 2014.
Guibas GV, Manios Y, Moschonis G, Xepapadaki P, Roumpedaki E, Lambrinou C-P, Papadopoulos NG. Infantile growth velocity and later asthma/wheeze: GENESIS and the Healthy Growth Study. Eur Respir J. 2014;43(6):1790-3.
Giannopoulou K, Livada I, Santamouris M, Saliari M, Assimakopoulos M, Caouris Y. The influence of air temperature and humidity on human thermal comfort over the greater Athens area. Sustainable Cities and Society [Internet]. 2014;10:184-194. Website
Konstantakou M, Stergiopoulos T, Likodimos V, Vougioukalakis GC, Sygellou L, Kontos AG, Tserepi A, Falaras P. Influence of fluorine plasma treatment of TiO2 films on the behavior of dye solar cells employing the Co(II)/(III) redox couple. Journal of Physical Chemistry C [Internet]. 2014;118:16760-16775. WebsiteAbstract
Fluorine plasma treatment was investigated as an appropriate means for the surface modification of TiO2 thin film electrodes and the optimization of their performance as photoanodes in dye solar cells (DSCs) employing the Co(II)/(III) redox shuttle and the organic D35 sensitizer. Detailed surface and structural characterization of the titania films by contact angle measurements, atomic force microscopy, profilometry, and Raman and UV-vis spectroscopy showed that high density SF6 plasma provoked severe film densification and thus an increase of the nanoparticles packing density, leaving intact the crystallinity, particle size, and optical bandgap. Surface fluorination of the TiO2 films was also identified by X-ray photoelectron spectroscopy. The combination of the above effects resulted in the enhancement of both photocurrent and power conversion efficiency of the corresponding DSCs at moderate plasma treatment durations, while the photovoltage decreased continuously as a function of the fluorine processing time. Electrochemical impedance spectroscopy analysis revealed a marked increase of the density and distribution of trap states due to fluorine induced surface states along with a systematic downward shift of the TiO2 conduction band, probably attributed to the electrostatic coupling of intercalated Li + cations with the polar Ti-F species at the TiO2 surface, in agreement with the Voc drop. In contrast, enhanced electron injection was inferred to underlie the observed Jsc and DSC performance improvements, as surface fluorination and the concomitant film densification slightly increased electron transport while hardly affecting dye loading capacity, light harvesting efficiency, and recombination kinetics, except for the case of prolonged plasma treatment. Effective control of the detrimental side effects of fluorine species can render this kind of plasma treatment a powerful method to tune the surface and electrical properties of TiO2 films and optimize the behavior and performance of the resulting DSC devices. © 2014 American Chemical Society.
Papaefthymiou MA, Bakoula C, Sarra A, Papassotiriou I, Chrousos GP, Bacopoulou F. Influence of hormonal parameters, bone mineral density and bone turnover on fracture risk in healthy male adolescents: A case control study. Journal of Pediatric Endocrinology and Metabolism [Internet]. 2014;27:685-692. Website
Miletic V, Maniadakis D, Mikac B, Varoutas D. On the influence of the underlying network topology on optical telecommunication network availability under shared risk link group failures. In: Design of Reliable Communication Networks (DRCN), 2014 10th International Conference on the. IEEE; 2014. pp. 1–8.
Kokotos G, Feuerherm AJ, Barbayianni E, Shah I, Saether M, Magrioti V, Nguyen T, Constantinou-Kokotou V, Dennis EA, Johansen B. Inhibition of group IVA cytosolic phospholipase A2 by thiazolyl ketones in vitro, ex vivo, and in vivo. Journal of Medicinal Chemistry. 2014;57:7523-7535.Abstract
Group IVA cytosolic phospholipase A2 (GIVA cPLA2) is the rate-limiting provider of pro-inflammatory mediators in many tissues and is thus an attractive target for the development of novel anti-inflammatory agents. In this work, we present the synthesis of new thiazolyl ketones and the study of their activities in vitro, in cells, and in vivo. Within this series of compounds, methyl 2-(2-(4-octylphenoxy)acetyl)thiazole-4-carboxylate (GK470) was found to be the most potent inhibitor of GIVA cPLA2, exhibiting an XI(50) value of 0.011 mole fraction in a mixed micelle assay and an IC50 of 300 nM in a vesicle assay. In a cellular assay using SW982 fibroblast-like synoviocytes, it suppressed the release of arachidonic acid with an IC50 value of 0.6 μM. In a prophylactic collagen-induced arthritis model, it exhibited an anti-inflammatory effect comparable to the reference drug methotrexate, whereas in a therapeutic model, it showed results comparable to those of the reference drug Enbrel. In both models, it significantly reduced plasma PGE2 levels.
Petrakis PE, Kostis PC, Valsamis DG. Innovation and Competitiveness: Culture as a Long-Term Strategic Instrument: Culture on Innovation and Competitiveness during the European Great Recession. In: 3rd Global Innovation and Knowledge Academy (GIKA) Conference. Valencia, Spain; 2014.
Zervou M, Cournia Z, Potamitis C, Patargias G, Durdagi S, Grdadolnik SG, Mavromoustakos T. Insights into the molecular basis of action of the AT1 antagonist losartan using a combined NMR spectroscopy and computational approach. Biochimica et Biophysica Acta - Biomembranes [Internet]. 2014;1838(3):1031 - 1046. Website
Pappa EP, Christopoulou ME, Mertzimekis TJ, Nomikou P, Carey S, Polymenakou P, Papanikolaou D. In-situ CTD scans as a probe for submarine volcano. [Internet]. 2014. Website
Sagonas K, Pafilis P, Lymberakis P, Donihue CM, Herrel A, Valakos ED. Insularity affects head morphology, bite force and diet in a Mediterranean lizard. Biological Journal of the Linnean Society. 2014;112:469-484.Abstract
Island environments differ with regard to numerous features from the mainland and may induce large-scale changes in most aspects of the biology of an organism. In this study, we explore the effect of insularity on the morphology and performance of the feeding apparatus, a system crucial for the survival of organisms. To this end, we examined the head morphology and feeding ecology of island and mainland populations of the Balkan green lizard, Lacerta trilineata. We predicted that head morphology, performance and diet composition would differ between sexes and habitats as a result of varying sexual and natural selection pressures. We employed geometric morphometrics to test for differences in head morphology, measured bite forces and analysed the diet of 154 adult lizards. Morphological analyses revealed significant differences between sexes and also between mainland and island populations. Relative to females, males had larger heads, a stronger bite and consumed harder prey than females. Moreover, island lizards differed in head shape, but not in head size, and, in the case of males, demonstrated a higher bite force. Islanders had a wider food niche breadth and included more plant material in their diet. Our findings suggest that insularity influences feeding ecology and, through selection on bite force, head morphology. © 2014 The Linnean Society of London, Biological Journal of the Linnean Society, 2014, ●●, ●●–●●.
Agrogiannis G, Patsouris E, Konstantinidou A. Insulin like growth factor 1 and Growth hormone expression in embryonic and fetal period. VIRCHOWS ARCHIV. 2014;465:S203-S203.
Agrogiannis GD, Sifakis S, Patsouris ES, Konstantinidou AE. Insulin-like growth factors in embryonic and fetal growth and skeletal development (Review). Molecular medicine reports. 2014;10(2):579-584.
Bousquet J, Addis A, Adcock I, Agache I, Agusti A, Alonso A, Annesi-Maesano I, Anto JM, Bachert C, Baena-Cagnani CE, et al. Integrated care pathways for airway diseases (AIRWAYS-ICPs). Eur Respir J. 2014;44(2):304-23.Abstract
The objective of Integrated Care Pathways for Airway Diseases (AIRWAYS-ICPs) is to launch a collaboration to develop multi-sectoral care pathways for chronic respiratory diseases in European countries and regions. AIRWAYS-ICPs has strategic relevance to the European Union Health Strategy and will add value to existing public health knowledge by: 1) proposing a common framework of care pathways for chronic respiratory diseases, which will facilitate comparability and trans-national initiatives; 2) informing cost-effective policy development, strengthening in particular those on smoking and environmental exposure; 3) aiding risk stratification in chronic disease patients, using a common strategy; 4) having a significant impact on the health of citizens in the short term (reduction of morbidity, improvement of education in children and of work in adults) and in the long-term (healthy ageing); 5) proposing a common simulation tool to assist physicians; and 6) ultimately reducing the healthcare burden (emergency visits, avoidable hospitalisations, disability and costs) while improving quality of life. In the longer term, the incidence of disease may be reduced by innovative prevention strategies. AIRWAYSICPs was initiated by Area 5 of the Action Plan B3 of the European Innovation Partnership on Active and Healthy Ageing. All stakeholders are involved (health and social care, patients, and policy makers).
Qahtani JA, Alaa E, Kallos G, Galanis G, Sofianos S, Mitsakou C, Spyrou C, Kalogeri C, Bartsotas N, Athanaselis J, et al. An integrated weather and sea state forecasting system for the Arabian Peninsula (WASSF). In: Springer Proceedings in Complexity. ; 2014. pp. 173-177. Website
Kotsiopoulou P, Tsironi M, Zyga S, Moisoglou I, Galanis P, Prezerakos P. Intensive Care Unit nurses’ attitude and knowledge toward transplantations and organs donation. νοσηλεία. 2014:48.
Kotsiopoulou P, Tsironi M, Zyga S, Moisoglou I, Galanis P, Prezerakos P. Intensive Care Unit nurses’ attitude and knowledge toward transplantations and organs donation. $ν$o$\sigma$$η$$łambda$$\varepsilon$$\acuteıota}$$\alpha$. 2014:48.
Chrysostomou S. Interactive text books in the music classroom: applications of an innovative project in Greece and Cyprus. International Society for Music Education 31st conference - Proceedings. 2014.
Vervatis VD, Skliris N, Sofianos SS. Inter-annual/decadal variability of north Aegean Sea hydrodynamics over 1960-2000. Mediterranean Marine Science [Internet]. 2014;15:696-705. Website
Palumbo A, Rajkumar SV, San Miguel JF, Larocca A, Niesvizky R, Morgan G, Landgren O, Hajek R, Einsele H, Anderson KC, et al. International Myeloma Working Group consensus statement for the management, treatment, and supportive care of patients with myeloma not eligible for standard autologous stem-cell transplantation. Journal of Clinical Oncology [Internet]. 2014;32(6):587 - 600. WebsiteAbstract
Purpose: To provide an update on recent advances in the management of patients with multiple myeloma who are not eligible for autologous stem-cell transplantation. Methods: A comprehensive review of the literature on diagnostic criteria is provided, and treatment options and management of adverse events are summarized. Results: Patients with symptomatic disease and organ damage (ie, hypercalcemia, renal failure, anemia, or bone lesions) require immediate treatment. The International Staging System and chromosomal abnormalities identify high- and standard-risk patients. Proteasome inhibitors, immunomodulatory drugs, corticosteroids, and alkylating agents are the most active agents. The presence of concomitant diseases, frailty, or disability should be assessed and, if present, treated with reduced-dose approaches. Bone disease, renal damage, hematologic toxicities, infections, thromboembolism, and peripheral neuropathy are the most frequent disabling events requiring prompt and active supportive care. Conclusion: These recommendations will help clinicians ensure the most appropriate care for patients with myeloma in everyday clinical practice. © 2014 by American Society of Clinical Oncology.
Ludwig H, Miguel JS, Dimopoulos MA, Palumbo A, Garcia Sanz R, Powles R, Lentzsch S, Ming Chen W, Hou J, Jurczyszyn A, et al. International Myeloma Working Group recommendations for global myeloma care. Leukemia [Internet]. 2014;28(5):981 - 992. WebsiteAbstract
Recent developments have led to remarkable improvements in the assessment and treatment of patients with multiple myeloma (MM). New technologies have become available to precisely evaluate the biology and extent of the disease, including information about cytogenetics and genetic abnormalities, extramedullary manifestations and minimal residual disease. New, more effective drugs have been introduced into clinical practice, which enable clinicians to significantly improve the outcome of patients but also pose new challenges for the prevention and management of their specific side effects. Given these various new options and challenges, it is important to identify the minimal requirements for diagnosis and treatment of patients, as access to the most sophisticated advances may vary depending on local circumstances. Here, we propose the minimal requirements and possible options for diagnosis, monitoring and treatment of patients with multiple myeloma. © 2014 Macmillan Publishers Limited. All rights reserved.
Rajkumar SV, Dimopoulos MA, Palumbo A, Blade J, Merlini G, Mateos M-V, Kumar S, Hillengass J, Kastritis E, Richardson P, et al. International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma. The Lancet Oncology [Internet]. 2014;15(12):e538 - e548. WebsiteAbstract
This International Myeloma Working Group consensus updates the disease definition of multiple myeloma to include validated biomarkers in addition to existing requirements of attributable CRAB features (hypercalcaemia, renal failure, anaemia, and bone lesions). These changes are based on the identification of biomarkers associated with near inevitable development of CRAB features in patients who would otherwise be regarded as having smouldering multiple myeloma. A delay in application of the label of multiple myeloma and postponement of therapy could be detrimental to these patients. In addition to this change, we clarify and update the underlying laboratory and radiographic variables that fulfil the criteria for the presence of myeloma-defining CRAB features, and the histological and monoclonal protein requirements for the disease diagnosis. Finally, we provide specific metrics that new biomarkers should meet for inclusion in the disease definition. The International Myeloma Working Group recommends the implementation of these criteria in routine practice and in future clinical trials, and recommends that future studies analyse any differences in outcome that might occur as a result of the new disease definition. © 2014 Elsevier Ltd.
Tosti R, Ilyas AM, Mellema JJ, Guitton TG, Ring D. Interobserver variability in the treatment of little finger metacarpal neck fractures. J Hand Surg Am. 2014;39(9):1722-7.Abstract
PURPOSE: To address the null hypothesis that surgeons shown radiographs of little finger metacarpal neck fractures with measured fracture angulation would recommend surgery as often as surgeons shown unmarked radiographs. METHODS: Members of the Science of Variation Group, an international collaboration of fully trained orthopedic and trauma surgeons, were asked to review 20 little finger metacarpal neck fracture cases, which included a vignette and 3 high-quality radiographs. Members were then randomized to review radiographs with or without measured fracture angulation on the lateral view and select operative or nonoperative management. RESULTS: Surgeons shown radiographs with measured angulation were more likely to recommend surgery, and there was less variability among these surgeons, particularly for fractures with less angular deformity. CONCLUSIONS: Measured fracture angulation has a small but significant influence on treatment recommendations for little finger metacarpal neck fractures. TYPE OF STUDY/LEVEL OF EVIDENCE: Diagnostic III.
Moschos MM, Chatziralli IP, Koutsandrea C. Intraocular lens power calculation in eyes with short axial length. Indian journal of ophthalmology. 2014;62:692.
Mitropoulos PG, Chatziralli IP, Parikakis EA, Peponis VG, Amariotakis GA, Moschos MM. Intravitreal ranibizumab for stage IV proliferative sickle cell retinopathy: a first case report. Case reports in ophthalmological medicine. 2014;2014.
Chatziralli I, Parikakis E, Peponis V, Tsiotra V, Mitropoulos P. Intravitreal ranibizumab for the treatment of irvine-gass syndrome. Acta Ophthalmologica. 2014;92.
Cokkinos DV. Introduction to Translational Cardiovascular Research. Springer; 2014.
Kalozoumis PA, Morfonios, V C, Diakonos FK, Schmelcher P. Invariants of Broken Discrete Symmetries. PHYSICAL REVIEW LETTERS. 2014;113(5).
Christopoulou M-E, Mertzimekis TJ, Nomikou P, Papanikolaou D, Carey S. Investigating the active hydrothermal field of Kolumbo volcano using CTD profiling. [Internet]. 2014. Website
Lagrange J-B, Psycharis G. Investigating the potential of computer environments for the teaching and learning of functions: A double analysis from two research traditions. Technology, Knowledge and Learning (formerly International Journal of Computers for Mathematical Learning) [Internet]. 2014;19(3):255-286. Article URLAbstract
The general goal of this paper is to explore the potential of computer environments for the teaching and learning of functions. To address this, different theoretical frameworks and corresponding research traditions are available. In this study, we aim to network different frameworks by following a ‘double analysis’ method to analyse two empirical studies based on the use of computational environments offering integrated geometrical and algebraic representations. The studies took place in different national and didactic contexts and constitute cases of Constructionism and Theory of Didactical Situations. The analysis indicates that ‘double analysis’ resulted in a deepened and more balanced understanding about knowledge emerging from empirical studies as regards the nature of learning situations for functions with computers and the process of conceptualisation of functions by students. Main issues around the potential of computer environments for the teaching and learning of functions concern the use of integrated representations of functions linking geometry and algebra, the need to address epistemological and cognitive aspects of the constructed knowledge and the critical role of teachers in the design and evolution of students’ activity. We also reflect on how the networking of theories influences theoretical advancement and the followed research approaches.
tknl_2014.pdf
Karditsa A, Poulos SE, Botsou F, Alexakis D, Stamatakis M. Investigation of major and trace element distribution patterns and pollution status of the surficial sediments of a microtidal inner shelf influenced by a transboundary river. The case of the Alexandroupolis Gulf (northeastern Aegean Sea, Greece). Journal of Geochemical Exploration [Internet]. 2014;146:105-118. Website
Spanos KN, Georgantzinos SK, Anifantis NK. Investigation of stress transfer in carbon nanotube reinforced composites using a multi-scale finite element approach. Composites Part B: Engineering. 2014;63:85-93.
Alexopoulos JD, Matiatos I, Dilalos S, E. V, Panagopoulos Α, Ghionis G, Poulos S. Investigation of the phreatic aquifer development at the Pinios Delta basin (Thessaly), through a combination of geophysical and hydrogeological data. 10th Congress of the Hellenic Geographical Society [Internet]. 2014. pdfAbstract
The present study aims to clarify the hydrogeological regime of the phreatic aquifer, primarily its spatial distribution, through a combined interpretation of the preliminary results of an extensive geophysical research conducted in the area and of the hydrogeological data collected in parallel scientific actions by previous researchers. In the context of the geophysical research that was carried out in the region, 37 Vertical Electrical Soundings, investigating the resistivity distribution (Schlumberger array), were performed during May and October 2013. Moreover, previous periodic measurements of the groundwater level of the phreatic aquifer and hydrochemical analysis were taken into consideration. The preliminary results of the geophysical data processing indicate that the phreatic aquifer is not detected throughout the whole deltaic plain but extends mainly in the central and northern parts of the region. Most of the investigated sites showed that the hosting formation’s thickness is limited up to 10 meters, since the underlying geoelectrical formation (20-40 Ohm.m) is believed to be an impermeable formation. The literature-derived hydrogeological data also indicate that the depth of the phreatic aquifer is generally small. In particular, the groundwater monitoring showed that the water table did not exceed 4m in depth. Moreover, the hydrochemical data indicated a limited seawater intrusion, which seems to be controlled by the hydraulic head of the groundwater and the sedimentological composition of the dune system covering the coastal zone, which is also indicated by the geophysical results.
Alexopoulos J, Matiatos I, Dilalos S, Vassilakis E, Panagopoulos A, Ghionis G, Poulos S. Investigation of the Pineios Delta (Thessaly) shallow aquifer development, combining geophysical and hydrogeological data. In: 10th Congress of the Hellenic Intern. Geographical Society. Thessaloniki, Greece; 2014. pp. 1130-1139. pdf
Mavridis S. Invitación a la muerte. Una aproximación a la dramaturgia de Xavier Villaurrutia a partir de la estética de Søren Kierkegaard. In: Estudios y homenajes hispanoamericanos. Vol. 2. Ediciones del Orto; 2014. pp. 165-171.
S S, M K, N T, I Z. Irrigating onions and potatoes with chromium and nickel : its effects on catalase and peroxidase activities and the cross-contamination of plants. Water, Air and Soil Pollution [Internet]. 2014;225(10):2142. Publisher's VersionAbstract
The scope of this study was to investigate the uptake of chromium and nickel by onions (Allium cepa) and potatoes (Solanum tuberosum) and their impact on plant enzymes catalase (CAT, E.C. 1.11.1.6) and peroxidase (POX, E.C. 1.11.1.7). A greenhouse experiment was conducted, simulating the irrigating conditions existing in the two biggest tuber-producing regions of Greece (Asopos and Messapia). Plants were cultivated for 4 months in six irrigation lines, each one supplied by an aqueous solution, containing levels of Cr(VI) and Ni(II) ranging from 0 μg/L (control) to 1,000 μg/L. Significant statistical correlations were observed between (i) the levels of heavy metals in plants, (ii) the levels of heavy metals in plants and in irrigation water, and (iii) the levels of heavy metals and the enzymatic activities in plants. The existing EU legislation has no legal limits for Ni and Cr in food, and the nutritional implications of this study are discussed.
Mousouri E, Melliou E, Magiatis P. Isolation of Megaritolactones and Other Bioactive Metabolites from ’Megaritiki’ Table Olives and Debittering Water. J Agric Food Chem. 2014.Abstract
’Megaritiki’ is an olive cultivar widely used in Greece for the production of low polyphenol olive oil and table olives. To investigate possible metabolic differentiation in comparison with other varieties, the composition of ’Megaritiki’ olive fruits and wastewaters from the debittering procedure was studied. Moreover, the recovery of bioactive metabolites from wastewater using adsorption resin was studied to exploit this byproduct. Metabolites in fruits and wastewaters were monitored using NMR spectroscopy. The major constituents of wastewater were hydroxytyrosol-4-O-glucoside, 11-methyl-oleoside, hydroxytyrosol, and tyrosol but not oleuropein. Furthermore, wastewater afforded rengyoxide and rengyoside B, which are for the first time isolated from olives. The final edible olives, besides hydroxytyrosol and tyrosol, contained rengyoxide and cleroindicin C, which are the first isolated from the species, haleridone for the first time isolated from edible olives, and four metabolites, which are the first reported as natural products, megaritodilactone, megaritolactonic acid, methyl ester of megaritolactonic acid B, and megaritolactonol.
Mousouri E, Melliou E, Magiatis P. Isolation of megaritolactones and other bioactive metabolites from ’Megaritiki’ table olives and debittering water. Journal of Agricultural and Food Chemistry [Internet]. 2014;62:660-667. WebsiteAbstract
’Megaritiki’ is an olive cultivar widely used in Greece for the production of low polyphenol olive oil and table olives. To investigate possible metabolic differentiation in comparison with other varieties, the composition of ’Megaritiki’ olive fruits and wastewaters from the debittering procedure was studied. Moreover, the recovery of bioactive metabolites from wastewater using adsorption resin was studied to exploit this byproduct. Metabolites in fruits and wastewaters were monitored using NMR spectroscopy. The major constituents of wastewater were hydroxytyrosol-4-O-glucoside, 11-methyl-oleoside, hydroxytyrosol, and tyrosol but not oleuropein. Furthermore, wastewater afforded rengyoxide and rengyoside B, which are for the first time isolated from olives. The final edible olives, besides hydroxytyrosol and tyrosol, contained rengyoxide and cleroindicin C, which are the first isolated from the species, haleridone for the first time isolated from edible olives, and four metabolites, which are the first reported as natural products, megaritodilactone, megaritolactonic acid, methyl ester of megaritolactonic acid B, and megaritolactonol. © 2014 American Chemical Society.
Koliopoulou M. Issues of Modern Greek and German compounding: a contrastive approach. Journal of Greek Linguistics. 2014;14(1):117-125.
Syriopoulos T, Roumpis E. The Journal of Economic Asymmetries. 2014.
Nistazakis HE, Stassinakis AN, Tombras GS, Muhammad SS, Tsigopoulos AD. K modeled turbulence and nonlinear clipping for QAM OFDM with FSO and fiber serially linked. In: 2014 20th International Conference on Microwaves, Radar and Wireless Communications, MIKON 2014. ; 2014. Website
Nistazakis HE, Stassinakis AN, Tombras GS, Muhammad SS, Tsigopoulos AD. K modeled turbulence and nonlinear clipping for QAM OFDM with FSO and fiber serially linked. In: 2014 20th International Conference on Microwaves, Radar and Wireless Communications, MIKON 2014. ; 2014. Website
Alexopoulou D, Kontos C, Christodoulou S, Papadopoulos I, Scorilas A. Kallikrein-related peptidase 11 (KLK11) mRNA expression predicts short-term relapse and poor overall survival in colorectal cancer patients: Kontos, Christos. Clinical Chemistry and Laboratory Medicine. 2014;52.
Christodoulou S, Alexopoulou DK, Kontos CK, Scorilas A, Papadopoulos IN. Kallikrein-related peptidase-6 (KLK6) mRNA expression is an independent prognostic tissue biomarker of poor disease-free and overall survival in colorectal adenocarcinoma. Tumor Biology [Internet]. 2014;35:4673-4685. Website
Christodoulou S, Alexopoulou DK, Kontos CK, Scorilas A, Papadopoulos IN. Kallikrein-related peptidase-6 (KLK6) mRNA expression is an independent prognostic tissue biomarker of poor disease-free and overall survival in colorectal adenocarcinoma. Tumor Biology. 2014;35:4673–4685.
Christodoulou S, Alexopoulou DK, Kontos CK, Scorilas A, Papadopoulos IN. Kallikrein-related peptidase-6 (KLK6) mRNA expression is an independent prognostic tissue biomarker of poor disease-free and overall survival in colorectal adenocarcinoma. Tumor Biology. 2014;35:4673-4685.
Papadimitriou P, Voulgaris N, Kouskouna V, Kassaras I, Kaviris G, Pavlou K, Karakonstantis A, Bozionelos G, Kapetanidis V. The Kefallinia Island earthquake sequence, January-February 2014. In: Second European Conference on Earthquake Engineering and Seismology (2ECEES). Istanbul, Turkey, 24-29 August, 2014; 2014.Abstract
A significant earthquake sequence was initiated on 26 January 2014 at the western part of the Kefallinia Island. The study area is located in the Ionian Sea (W. Greece) at the northwestern end of the Hellenic Arc – Trench, in a region dominated by the Kefallinia - Lefkada transform fault, which exhibits dextral strike–slip motion at a rate of 2–3 cm year−1During the historical period, until 1900, 13 earthquakes with magnitude Μ≥6.0, have been reported in the Kefallinia region. The strongest event, of magnitude 7.4 and intensity X at Lixouri, occurred on 4 February 1867 (Papazachos and Papazachou, 2003; Stucchi et al., 2012). Major destructions were reported at the villages of the Paliki peninsula, while in Lixouri only two houses did not collapse. Ground ruptures were observed, as well as a tsunami of small height. Rock falls and liquefactions also occurred. In the Paliki peninsula 2612 houses collapsed, while only 4 in Argostoli, the capital and major town of the Kefallinia Island. Since 1900, 11 earthquakes with magnitude Μs≥6.0 occurred (Makropoulos et al., 2012) in the region. Five of them took place in 1953, four of which during August. The largest event had a magnitude equal to 7.3 and maximum intensity X+ in Argostoli. This earthquake was preceded by two strong events (Ms=6.1 and 6.8). The Ionian islands of Kefallinia, Zakynthos and Ithaca suffered very severe damages. Among the 33300 houses, 27659 collapsed. The highest intensities (IX-X) were observed, among other locations, at Argostoli, Lixouri and Valsamata. Thirty years later, on 17 January 1983, an event with magnitude Ms=7.0 occurred approximately 30 km SW of Lixouri, causing moderate damage. The most recent moderate event (Mw=5.6) occurred on 25 March 2007, 5 km NE of Mirtos Bay. (Kahle et al., 1996; Cocard et al., 1999). This region is situated between the Hellenic subduction zone to the south and the Apulia - Eurasian collision zone to the north. Focal mechanisms reveal right-lateral strike-slip motion (Anderson and Jackson, 1987; Jackson and McKenzie, 1988), coherent with geodetic data, according to which the slip motion has a NNE–SSW direction (Cocard et al., 1999; Jenny et al., 2004).On Sunday 26 January 2014 (13:55 GMT) a strong shallow earthquake of magnitude Mw=6.1 occurred in the study area. The epicenter is located about 2 km NE of Lixouri. It is worth noting that no significant earthquake sequence was recorded at the Paliki Penisula during the last decades. The main shock and the aftershock sequence were recorded by seismographs of the Hellenic Unified Seismological Network (HUSN), which involves the Seismological Laboratories of the Athens and  Patras Universities, the Department of Geophysics of the Thessaloniki University and the Geodynamic Institute of the National Observatory of Athens (GI-NOA).Ground motion of the 26-1-2014 mainshock (Mw=6.1) was recorded by three permanent accelerographs located in Argostoli, Lixouri and Vassilikiades (ITSAK-EPPO, GI-NOA) with the response spectra in Lixouri indicating high horizontal acceleration. Moreover, the vertical component exhibited high spectral acceleration at a lower period when compared to the horizontal ones. Similar pattern is observed for the next strong event, which occurred on February 3, 2014 (Mw=5.9). A temporary accelerograph installed complementary to the permanent stations by GI-NOA in Chavriata, south of Lixouri, recorded an effective acceleration of 1g for the latter event, surprisingly exceeding the Greek Seismic Code provisions (0.36 g), being the highest recorded in Greece.The aftershock sequence was intense, while five hours after the mainshock, an aftershock of magnitude Μw=5.2 occurred. This sequence continued for a week with more than 30 events having magnitude greater than 4.0, till the occurrence of a strong earthquake of magnitude Μw=5.9. Its epicenter was located at the northwestern part of the Paliki peninsula. The earthquake sequence consists of more than 2000 events, the focal depths of which range mainly between 4 and 18 km. The aftershocks spatial distribution indicates that the activated seismogenic area is about 30 km length, in a NNE direction, located onshore in Paliki peninsula. At least three clusters can be distinguished. It is bounded to the south by the Vardiani islet and to the north by Myrto’s bay.The source parameters determination of the two strongest events were determined using body-wave modeling and teleseismic recordings. Synthetic waves are calculated by the trial-and-error method to determine the focal mechanism, the focal depth, and the seismic moment for a single trapezoidal source time function (Papadimitriou et al., 2006). Focal mechanisms of the strongest aftershocks have also been determined using the moment tensor inversion method developed by the Seismological Laboratory of the University of Athens (Papadimitriou et al., 2012). The data used are digital waveforms, recorded in regional distances by stations of HUSN. The observed seismograms were band-pass filtered between 0.02 Hz to 0.08 Hz. Following, Green Functions were calculated using the method proposed by Bouchon (1981). The inversion method revealed strike-slip focal mechanisms, in agreement with the fault plane solutions of the two main shocks. The results point out a dextral strike-slip rupture, oriented in a NNE-SSW direction. Taking into account both the aftershock spatial distribution and the focal mechanisms, it is concluded that the activated area does not coincide with the regional catalogue seismicity that is attributed to the Kefallinia - Lefkada transform fault, located offshore. Hence, activation of a sub-parallel major fault can be considered, compatible with the active tectonics of the region, which is crucial for its seismic hazard.
E06_2014_ecees_kefallinia.pdf
Papadimitriou P, Voulgaris N, Kouskouna V, Kassaras I, Kaviris G, Pavlou K, Karakonstantis A, Bozionelos G, Kapetanidis V. The Kefallinia Island earthquake sequence, January-February 2014. In: Second European Conference on Earthquake Engineering and Seismology (2ECEES). Istanbul, Turkey, 24-29 August, 2014; 2014.Abstract
A significant earthquake sequence was initiated on 26 January 2014 at the western part of the Kefallinia Island. The study area is located in the Ionian Sea (W. Greece) at the northwestern end of the Hellenic Arc – Trench, in a region dominated by the Kefallinia - Lefkada transform fault, which exhibits dextral strike–slip motion at a rate of 2–3 cm year−1During the historical period, until 1900, 13 earthquakes with magnitude Μ≥6.0, have been reported in the Kefallinia region. The strongest event, of magnitude 7.4 and intensity X at Lixouri, occurred on 4 February 1867 (Papazachos and Papazachou, 2003; Stucchi et al., 2012). Major destructions were reported at the villages of the Paliki peninsula, while in Lixouri only two houses did not collapse. Ground ruptures were observed, as well as a tsunami of small height. Rock falls and liquefactions also occurred. In the Paliki peninsula 2612 houses collapsed, while only 4 in Argostoli, the capital and major town of the Kefallinia Island. Since 1900, 11 earthquakes with magnitude Μs≥6.0 occurred (Makropoulos et al., 2012) in the region. Five of them took place in 1953, four of which during August. The largest event had a magnitude equal to 7.3 and maximum intensity X+ in Argostoli. This earthquake was preceded by two strong events (Ms=6.1 and 6.8). The Ionian islands of Kefallinia, Zakynthos and Ithaca suffered very severe damages. Among the 33300 houses, 27659 collapsed. The highest intensities (IX-X) were observed, among other locations, at Argostoli, Lixouri and Valsamata. Thirty years later, on 17 January 1983, an event with magnitude Ms=7.0 occurred approximately 30 km SW of Lixouri, causing moderate damage. The most recent moderate event (Mw=5.6) occurred on 25 March 2007, 5 km NE of Mirtos Bay. (Kahle et al., 1996; Cocard et al., 1999). This region is situated between the Hellenic subduction zone to the south and the Apulia - Eurasian collision zone to the north. Focal mechanisms reveal right-lateral strike-slip motion (Anderson and Jackson, 1987; Jackson and McKenzie, 1988), coherent with geodetic data, according to which the slip motion has a NNE–SSW direction (Cocard et al., 1999; Jenny et al., 2004). On Sunday 26 January 2014 (13:55 GMT) a strong shallow earthquake of magnitude Mw=6.1 occurred in the study area. The epicenter is located about 2 km NE of Lixouri. It is worth noting that no significant earthquake sequence was recorded at the Paliki Penisula during the last decades. The main shock and the aftershock sequence were recorded by seismographs of the Hellenic Unified Seismological Network (HUSN), which involves the Seismological Laboratories of the Athens and Patras Universities, the Department of Geophysics of the Thessaloniki University and the Geodynamic Institute of the National Observatory of Athens (GI-NOA). Ground motion of the 26-1-2014 mainshock (Mw=6.1) was recorded by three permanent accelerographs located in Argostoli, Lixouri and Vassilikiades (ITSAK-EPPO, GI-NOA) with the response spectra in Lixouri indicating high horizontal acceleration. Moreover, the vertical component exhibited high spectral acceleration at a lower period when compared to the horizontal ones. Similar pattern is observed for the next strong event, which occurred on February 3, 2014 (Mw=5.9). A temporary accelerograph installed complementary to the permanent stations by GI-NOA in Chavriata, south of Lixouri, recorded an effective acceleration of 1g for the latter event, surprisingly exceeding the Greek Seismic Code provisions (0.36 g), being the highest recorded in Greece. The aftershock sequence was intense, while five hours after the mainshock, an aftershock of magnitude Μw=5.2 occurred. This sequence continued for a week with more than 30 events having magnitude greater than 4.0, till the occurrence of a strong earthquake of magnitude Μw=5.9. Its epicenter was located at the northwestern part of the Paliki peninsula. The earthquake sequence consists of more than 2000 events, the focal depths of which range mainly between 4 and 18 km. The aftershocks spatial distribution indicates that the activated seismogenic area is about 30 km length, in a NNE direction, located onshore in Paliki peninsula. At least three clusters can be distinguished. It is bounded to the south by the Vardiani islet and to the north by Myrto’s bay. The source parameters determination of the two strongest events were determined using body-wave modeling and teleseismic recordings. Synthetic waves are calculated by the trial-and-error method to determine the focal mechanism, the focal depth, and the seismic moment for a single trapezoidal source time function (Papadimitriou et al., 2006). Focal mechanisms of the strongest aftershocks have also been determined using the moment tensor inversion method developed by the Seismological Laboratory of the University of Athens (Papadimitriou et al., 2012). The data used are digital waveforms, recorded in regional distances by stations of HUSN. The observed seismograms were band-pass filtered between 0.02 Hz to 0.08 Hz. Following, Green Functions were calculated using the method proposed by Bouchon (1981). The inversion method revealed strike-slip focal mechanisms, in agreement with the fault plane solutions of the two main shocks. The results point out a dextral strike-slip rupture, oriented in a NNE-SSW direction. Taking into account both the aftershock spatial distribution and the focal mechanisms, it is concluded that the activated area does not coincide with the regional catalogue seismicity that is attributed to the Kefallinia - Lefkada transform fault, located offshore. Hence, activation of a sub-parallel major fault can be considered, compatible with the active tectonics of the region, which is crucial for its seismic hazard.
E06_2014_ecees_kefallinia.pdf
Giovanis V. Kinematic analysis and tactics of women's cross-country skiing. Physical Education and Sport journal (in Polish). 2014;58(1):1-10.
Dalamaga M, Kazanis K, Triantafyllidi H, Vagionas I, Dionyssiou-Asteriou A. Kinetics of serum ischemia-modified albumin during cardiopulmonary exercise testing in relation to metabolic and cardiac markers: a pilot study. Metabolism. 2014;63(4):e5-6.
Alexopoulou DK, Kontos CK, Christodoulou S, Papadopoulos IN, Scorilas A. KLK11 mRNA expression predicts poor disease-free and overall survival in colorectal adenocarcinoma patients. Biomarkers in medicine. 2014;8:671–685.
Alexopoulou DK, Kontos CK, Christodoulou S, Papadopoulos IN, Scorilas A. KLK11 mRNA expression predicts poor disease-free and overall survival in colorectal adenocarcinoma patients. Biomarkers in Medicine [Internet]. 2014;8:671-685. Website
Alexopoulou DK, Kontos CK, Christodoulou S, Papadopoulos IN, Scorilas A. KLK11 mRNA expression predicts poor disease-free and overall survival in colorectal adenocarcinoma patients. Biomarkers in Medicine. 2014;8:671-685.
Koliopoulou M. Komposition im Deutschen und Neugriechischen: eine kontrastive morphologische Analyse. In: Sprachen und Kulturen in (Inter)Aktion. 2. Teil- Linguistik, Didaktik, Translationswissenschaft. Peter Lang; 2014. pp. 43-56.
MacGinnis J, Kopanias K. Kurdistan: A new dawn breaks for Near Eastern Archaeology. Current World Archaeology. 2014;67:32-35. paper_2014_kurdistan_a_new_dawn_breaks.pdf
Mazis I. La crise économique mondiale et la redistribution de l’équilibre des forces au Moyen Orient. In: Discours inaugural au Congrès annuel de Galatasaray Üniversitesi. İstanbul, Türkiye: Galatasaray Üniversitesi; 2014.Abstract
Depuis l’année de départ de la crise, en 2008 jusqu’à ce jour, s’est révélé aux yeux des intéressés, la tendance des fonds occidentaux et des investisseurs vers la zone pacifique, où deux faits s’imposent : 1) le coût du travail moyen se situe autour de 5% et 2) le pourcentage de plus-value au niveau international est immense et du niveau 500600%, après déduction de tout coût de capital (impôts, coûts opérationnels, etc.). Ce phénomène n’a pas laissé la Russie non plus indifférente. Par ailleurs, le rythme de fonte des glaces en Arctique change la donne stratégique et offre pour le futur des perspectives de navigations pour la Russie vers le Pacifique, via le détroit de Bérin.
lvii._la_crise_economique_mondiale_et_la_redistribution_de_lequilibre_des_forces_au_moyen_orient.pdf

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