In this paper we propose and test a methodology for constructing a credit rating model. We follow a polytomous ordered probit analysis leading to the specification of statistically significant credit rating intervals. We test our model with accounting data of Greek listed firms over the years 2004–2013, a period which includes both the pre-crisis growth and the crisis phase of the Greek economy and the stock market. Using the empirically—based rating categories that the model generates endogenously, we observe not only a clear and timely response of ratings to the changing economic environment, but we also obtain significant predictive ability over a period of one, two and three years.
In this paper we propose and test a methodology for constructing a credit rating model. We follow a polytomous ordered probit analysis leading to the specification of statistically significant credit rating intervals. We test our model with accounting data of Greek listed firms over the years 2004–2013, a period which includes both the pre-crisis growth and the crisis phase of the Greek economy and the stock market. Using the empirically—based rating categories that the model generates endogenously, we observe not only a clear and timely response of ratings to the changing economic environment, but we also obtain significant predictive ability over a period of one, two and three years.
Mitochondria are highly dynamic organelles that provide essential metabolic functions and represent the major bioenergetic hub of eukaryotic cell. Therefore, maintenance of mitochondria activity is necessary for the proper cellular function and survival. To this end, several mechanisms that act at different levels and time points have been developed to ensure mitochondria quality control. An interconnected highly integrated system of mitochondrial and cytosolic chaperones and proteases along with the fission/fusion machinery represents the surveillance scaffold of mitostasis. Moreover, nonreversible mitochondrial damage targets the organelle to a specific autophagic removal, namely, mitophagy. Beyond the organelle dynamics, the constant interaction with the ubiquitin-proteasome-system (UPS) has become an emerging aspect of healthy mitochondria. Dysfunction of mitochondria and UPS increases with age and correlates with many age-related diseases including cancer and neurodegeneration. In this review, we discuss the functional cross talk of proteostasis and mitostasis in cellular homeodynamics and the impairment of mitochondrial quality control during ageing, cancer, and neurodegeneration.
Background/Aim: Peripheral blood mononuclear cells (PBMCs) activated with immobilized monoclonal antibody against cluster of differentiation 3 (CD3) secrete cytokines in their culture supernatant (termed ACD3S). We examined the antitumor efficacy of ACD3S-activated NK-92 cells in vitro and in vivo. Materials and Methods: Interleukin (IL) 2-depleted NK-92 cells were reactivated with ACD3S, analyzed for their phenotype and tested for cytotoxicity, and perforin and interferon (IFN) production. Severe combined immunodeficient (SCID) mice xenografted with human melanoma and breast cancer cells were treated with ACD3S-activated NK-92 cells and tumor growth was monitored. Results: Brief activation of IL2-depleted NK-92 cells with ACD3S fully restored their in vitro cytotoxicity towards tumor cells. ACD3S-activated NK-92 cells were phenotypically similar to standard NK-92 cells, but exhibited prolonged cytotoxicity and produced higher levels of IFN. When adoptively transferred to tumor-bearing SCID mice, these cells retarded the growth of melanoma and breast tumors. Conclusion: Stimulation of NK-92 cells with ACD3S may be useful in clinical cancer therapy, as an alternative method for ex vivo natural killer cell activation.
A twin-experiment is carried out introducing elements of an Ensemble Kalman Filter (EnKF), to assess and correct ocean uncertainties in a high-resolution Bay of Biscay configuration. Initially, an ensemble of 102 members is performed by applying stochastic modeling of the wind forcing. The target of this step is to simulate the envelope of possible realizations and to explore the robustness of the method at building ensemble covariances. Our second step includes the integration of the ensemble-based error estimates into a data assimilative system adopting a 4D Ensemble Optimal Interpolation (4DEnOI) approach. In the twin-experiment context, synthetic observations are simulated from a perturbed member not used in the subsequent analyses, satisfying the condition of an unbiased probability distribution function against the ensemble by performing a rank histogram. We evaluate the assimilation performance on short-term predictability focusing on the ensemble size, the observational network, and the enrichment of the ensemble by inexpensive time-lagged techniques. The results show that variations in performance are linked to intrinsic oceanic processes, such as the spring shoaling of the thermocline, in combination with external forcing modulated by river runoffs and time-variable wind patterns, constantly reshaping the error regimes. Ensemble covariances are able to capture high-frequency processes associated with coastal density fronts, slope currents and upwelling events near the Armorican and Galician shelf break. Further improvement is gained when enriching model covariances by including pattern phase errors, with the help of time-neighbor states augmenting the ensemble spread.
We focus in the period of announcement of accounting information for companies listed in an organized market and we re-examine their probability of delisting, voluntarily or not. Adopting the same framework, consideration is given to the assumption that investors utilize market information when accounting data are published. The analysis provided indicates that investors should pay attention to the financial disclosure timing. Our investigation demonstrated that even the short period of three months is quite important to making investment decisions.
In the course of our study on fungal purine transporters, a number of new 3-deazapurine analogues have been rationally designed, based on the interaction of purine substrates with the Aspergillus nidulans FcyB carrier, and synthesized following an effective synthetic procedure. Certain derivatives have been found to specifically inhibit FcyB-mediated [(3)H]-adenine uptake. Molecular simulations have been performed, suggesting that all active compounds interact with FcyB through the formation of hydrogen bonds with Asn163, while the insertion of hydrophobic fragments at position 9 and N6 of 3-deazaadenine enhanced the inhibition.
The detection of periodicity in the broadband non-thermal emission of blazars has so far been proven to be elusive. However, there are a number of scenarios that could lead to quasi-periodic variations in blazar light curves. For example, an orbital or thermal/viscous period of accreting matter around central supermassive black holes could, in principle, be imprinted in the multi-wavelength emission of small-scale blazar jets, carrying such crucial information about plasma conditions within the jet launching regions. In this paper, we present the results of our time series analysis of the ∼9.2 yr long, and exceptionally well-sampled, optical light curve of the BL Lac object OJ 287. The study primarily used the data from our own observations performed at the Mt. Suhora and Kraków Observatories in Poland, and at the Athens Observatory in Greece. Additionally, SMARTS observations were used to fill some of the gaps in the data. The Lomb-Scargle periodogram and the weighted wavelet Z-transform methods were employed to search for possible quasi-periodic oscillations in the resulting optical light curve of the source. Both methods consistently yielded a possible quasi-periodic signal around the periods of ∼400 and ∼800 days, the former with a significance (over the underlying colored noise) of ≥slant 99 % . A number of likely explanations for this are discussed, with preference given to a modulation of the jet production efficiency by highly magnetized accretion disks. This supports previous findings and the interpretation reported recently in the literature for OJ 287 and other blazar sources.
Macheras P, Iliadis A. Deterministic Compartmental Models. In: MODELING IN BIOPHARMACEUTICS, PHARMACOKINETICS AND PHARMACODYNAMICS: HOMOGENEOUS AND HETEROGENEOUS APPROACHES, 2ND EDITION. Vol. 30. 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES: SPRINGER; 2016. pp. 191-210.
OBJECTIVES: Recent reports have included PALB2 (Partner and localizer of BRCA2) in the growing list of hereditary cancer genes. PALB2 mutations confer a moderate breast cancer risk in heterozygotes and Fanconi anemia in biallelic mutation carriers. PALB2 protein co-localizes with BRCA2 and BRCA1 in nuclear structures and enables error-free homologous recombination repair of double-stranded DNA breaks. This important contribution could be severely diminished if affected by epigenetic mechanisms such as promoter CpG island methylation. The aim of our study was to develop molecular methodologies in order to assess accurately PALB2 expression in breast cancer tissues. DESIGN AND METHODS: DNA and RNA were extracted from 91 sporadic fresh-frozen breast tissues with known histopathological data. DNA was subjected to sodium bisulfite conversion reaction and the CpG island of the PALB2 promoter was analyzed by pyrosequencing. RNA was converted to cDNA and analyzed by a newly developed and validated RT-qPCR assay based on a hydrolysis probe (TaqMan) in the Light Cycler. RESULTS: PALB2 promoter was not methylated in any of the samples tested. 87 out of 91 (95.6%) primary tumors were positive for PALB2 expression, as checked at the mRNA level. When levels of PALB2 mRNA were compared to histopathological data (tumor size, grade, lymph node involvement, metastasis, hormone receptors and HER2 overexpression), no significant statistical correlation was found. CONCLUSIONS: DNA methylation is an unlike mechanism for PALB2 transcriptional regulation. PALB2 mRNA expression does not seem be a promising prognostic biomarker for sporadic breast cancer
Beyond BRCA1 and BRCA2 genes, PALB2 (Partner and localizer of BRCA2) emerges as the third breast cancer susceptibility gene due to its role in the same DNA repair pathway: homologous recombination. In most populations studied so far, PALB2 mutations are detected in 1-2% of BRCA negative female patients. PALB2 gene contains 13 exons; exons 4 and 5 consist 65% of the coding area. We developed a protein truncation test (PTT) for quick screening of truncating pathogenic mutations of these two large exons. Specific primers were de novo, in silico designed and the PTT-PCR products were translated in the presence of biotinylated lysine and detected colorimetrically. The assay was initially tested in 30 patients with hereditary breast cancer, negative for BRCA mutations and then, in 17 patients with the rare medullary breast cancer subtype. Small PALB2 exons were screened with high-resolution melting curve analysis (HRMA) and the large DNA rearrangements with multiplex ligation-dependent probe amplification (MLPA). Any alterations detected were verified by Sanger DNA Sequencing. The developed PTT methodology is highly specific for clinical significant mutations; positive control samples that produce truncated PALB2 peptides were correctly identified and the method was accurate when compared to DNA sequencing. We did not detect any deleterious PALB2 mutation in both groups of patients. HRMA and MLPA were also negative for all tested samples. However, our novel, fast and cost-effective PTT method for pathogenic mutation detection of the two large PALB2 exons can be applied in screening of a large number of breast cancer patients
Corinth Canal is an important technical construction with a significant role in marine and land transportation for Greece. Whilst the main highway of the Corinth bridge is well monitored there is no similar monitoring scheme for landslide failures of the canal walls. This work presents an in-house developed real-time early warning landslide triggering system using wireless sensor network (WSN) nodes. Specifically, for the detection of different types of landslide processes (drift, slide and fall) a set of corresponding MEMS (Micro-Electro-Mechanical Systems) sensors (accelerometer, inclinometer, magnetometer) will be used. These sensors along with radio transmission unit and microprocessor comprise a WSN node. The option for in-situ processing (i.e transmitting only alerts) is possible in order to decrease the communication costs. In conjunction with the proposed WSN system, high accuracy geodetic techniques are used with terrestrial laser scanning (TLS) measurements. TLS is augmenting the point-based system to a spatial -based monitoring system. The paper describes the use of WSN node as triggering device in order to alert the users to begin TLS measurements. A description of the network topology is given along with the implementation of the system in selected control points on the canal walls. Real results are shown and the performance of the system is discussed.
Stylianopoulou F, Stamatakis A. Developmental aspects of memory processes. The Curated Reference Collection in Neuroscience and Biobehavioral Psychology. 2016:403-413.
Selective serotonin reuptake inhibitor medication exposure during the perinatal period can have a long term impact in adult offspring on neuroplasticity and the serotonergic system, but the impact of these medications during early development is poorly understood. The aim of this study was to determine the effects of developmental exposure to the SSRI, fluoxetine, on the serotonergic system, dopaminergic system, and synaptophysin density in the prefrontal cortex and hippocampus, as well as number of immature neurons in the dentate gyrus, in juvenile rat offspring at weaning. To model aspects of maternal depression, prenatal restraint stress was used. Sprague-Dawley rat offspring were exposed to either prenatal stress and/or fluoxetine. Main findings show that developmental fluoxetine exposure to prenatally stressed offspring decreased 5-HT and 5-HIAA levels and altered the dopaminergic system in the hippocampus. Prenatal stress, regardless of fluoxetine, increased synaptophysin density in the PFC. This work indicates that early exposure to maternal stress and SSRI medication can alter brain monoamine levels and synaptophysin density in offspring at weaning.
Selective serotonin reuptake inhibitor medication exposure during the perinatal period can have a long term impact in adult offspring on neuroplasticity and the serotonergic system, but the impact of these medications during early development is poorly understood. The aim of this study was to determine the effects of developmental exposure to the SSRI, fluoxetine, on the serotonergic system, dopaminergic system, and synaptophysin density in the prefrontal cortex and hippocampus, as well as number of immature neurons in the dentate gyrus, in juvenile rat offspring at weaning. To model aspects of maternal depression, prenatal restraint stress was used. Sprague-Dawley rat offspring were exposed to either prenatal stress and/or fluoxetine. Main findings show that developmental fluoxetine exposure to prenatally stressed offspring decreased 5-HT and 5-HIAA levels and altered the dopaminergic system in the hippocampus. Prenatal stress, regardless of fluoxetine, increased synaptophysin density in the PFC. This work indicates that early exposure to maternal stress and SSRI medication can alter brain monoamine levels and synaptophysin density in offspring at weaning.
Macheras P, Iliadis A. Diffusion and Kinetics. In: MODELING IN BIOPHARMACEUTICS, PHARMACOKINETICS AND PHARMACODYNAMICS: HOMOGENEOUS AND HETEROGENEOUS APPROACHES, 2ND EDITION. Vol. 30. 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES: SPRINGER; 2016. pp. 15-36.
Transporters are transmembrane proteins mediating the selective uptake or efflux of solutes, metabolites, drugs, or ions across cellular membranes. Despite their immense biological importance in cell nutrition, communication, signaling, and homeostasis, their study remains technically difficult mostly due to their lipid-embedded nature. The study of eukaryotic transporters presents additional complexity due to multiple subcellular control mechanisms that operate to ensure proper membrane traffic, membrane localization, and turnover. Model fungi present unique genetic tools to study eukaryotic transporter function. This review highlights how fungal transporter genetics combined with new methodologies for assaying their cellular expression and function as well as recent structural approaches have led to the functional dissection of selected transporter paradigms in Aspergillus nidulans.
In: A. Blum, K. Gavroglu, C. Joas, and J. Renn (eds.), Shifting Paradigms: Thomas S. Kuhn and the History of Science. Berlin: Edition Open Access, Max Planck Institute for the History of Science; 2016. pp. 191-201.2016a.pdf
Nega AD, Pefkianakis EK, Vougioukalakis GC, Glynos E, Sakellariou G.
. European Polymer Journal [Internet]. 2016;83:148-160.
We present a strategy for the synthesis of a well-defined rod-coil block copolymers of regioregular poly(3hexylthiophene) and polystyrene (P3HT-b-PS), carrying pendant fullerenes (C60) at precise positions along the PS block. The synthesis is achieved by combining ‘living’ anionic polymerization, Kumada catalyst-transfer polycondensation, and click chemistry. Azide terminated polystyrene was synthesized via anionic polymerization, while C60 moieties were grafted along the coil block with a [4+2] Diels-Alder cycloaddition reaction. The regioregular poly(3-hexylthiophene) rod donor block was end-capped with alkyne and was coupled with the azide terminated polystyrene via a copper catalyzed alkyne-azide cycloaddition. Size exclusion chromatography (SEC), NMR, and FTIR spectroscopies were employed to confirm the synthesis of the diblock copolymers. Furthermore, the end-capping of the ‘living’ polystyrene (PS) with the diphenylethylene cyclobutene (DPE-CB) end-group was confirmed by matrixassisted laser desorption/ionization time-of-flight mass spectroscopy (MALDI-TOF MS). Thermogravimetric analysis (TGA) was employed for the estimation of the C60 content in the block copolymer. The C60 content at the coil block was 22 wt% and a strong quenching of photoluminescence (PL) was observed as the result of the aggregation and percolation structure of the C60 within the PS phase. This behavior indicates that the bonding of C60 across the PS block may offer new routes to engineering stable morphologies, where the degree of aggregation/crystallization of the acceptor material is of paramount importance for stable and efficient electron transport.
. Cultural and Religious Studies. 2016;4(2):121-133. Doi: 10.17265/2328-2177/2016.02.004 .
The presentation of the findings of this article is based on an action research focused on the supportive role of the school in adolescents’ lives, whereby Religious Education’s contribution to the social and emotional development of adolescents (11-15) is combined with the evaluation of the potential offered by a constructivist approach to the learning process. The research commenced in 2012 and is now in its third year. The project is based on an intervention at a high school in an impoverished suburb of Athens and researches educational practices through interpretative-ethnographic methods. The researcher has attempted to answer the question of whether the design of the learning environments is effective not only in the learning process, but also on inter-communication and “connectedness” between the members of the learning community. The findings so far indicate a correlation between adolescents’ emotional and social wellbeing and the school’s approach to knowledge and learning methods, specifically in Religious Education classes. It is fair to say, however, that there exist ethnic, social and family components that are negatively related to a sense of “connectedness” within the school although at the same time Religious Education as a subject is, however, found to be positively related to learning community atmosphere.
A literature review was conducted to present if travellers accept the mobile healthcare (m-Health) technologies. The research was run on international scientific databases using certain keywords to cover the content of the review. From the online search results, 21 publications were selected which combine the "m-Health", "travellers" and "technology acceptance" topics. The majority of the papers are using the Technology Acceptance Model (or a variation of it) on their methodology. Only few papers discuss about the above three topics simultaneously. All of the publications highlight the acceptance of the mobile technologies by their users. Based on this, it can be assumed that travellers may accept the m-Health applications. Further investigation is needed on this subject to give more accurate results.
BACKGROUND: The objective of this study was to investigate whether multistranded fixed retainers prevented overeruption of unopposed mandibular second molars in maxillary first molar extraction cases.
METHODS: The panoramic radiographs of 65 Class II Division 1 Caucasian Whites (28 females, 37 males) consecutively treated with bilateral maxillary first molar extraction and the Begg technique, and with records taken after treatment (T1) and in retention (T2), were withdrawn from private practice records. After appliance removal, mandibular second molars were retained with sectional wires till at least T2 in case of lack of occlusal contact with the antagonist. The subjects were assigned to study-retention and control-nonretention groups based on the retention status of mandibular second molars. Radiographic analysis was carried out to determine inclination of mandibular molars and the resulting movement of second molar centroids. Parametric and nonparametric tests were performed to assess the changes between T1 and T2.
RESULTS: No statistically significant differences in molar inclination were observed between groups and timepoints (P > 0.05). There were no statistically significant differences in molar movement percentages (P > 0.05) irrespective of whether fixed retention had been used or not.
CONCLUSIONS: No significant eruption occurred in unopposed mandibular second molars bonded with fixed sectional retainers compared to molars partially occluded with the antagonists without fixed retention. Given the study limitations, fixed retention should be considered with caution in restricting tooth overeruption in unopposed molars.
Macheras P, Iliadis A. Drug Dissolution. In: MODELING IN BIOPHARMACEUTICS, PHARMACOKINETICS AND PHARMACODYNAMICS: HOMOGENEOUS AND HETEROGENEOUS APPROACHES, 2ND EDITION. Vol. 30. 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES: SPRINGER; 2016. pp. 83-108.
Macheras P, Iliadis A. Drug Release. In: MODELING IN BIOPHARMACEUTICS, PHARMACOKINETICS AND PHARMACODYNAMICS: HOMOGENEOUS AND HETEROGENEOUS APPROACHES, 2ND EDITION. Vol. 30. 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES: SPRINGER; 2016. pp. 53-82.
We report on the influence of elastic waves on the optical response and light emission in simultaneously photonic and phononic resonant cavities. Elastic waves couple with light through the acousto-optic interaction. Concurrent control of both light and sound through simultaneously photonic–phononic, often called phoxonic, band-gap structures is intended to advance both our understanding as well as our ability to manipulate light with sound and vise versa. In particular, co-localization of light and sound in phoxonic cavities could trigger nonlinear absorption and emission processes and lead to enhanced acousto-optic effects. We review our recent work on sound-controlled optical response and light emission in phoxonic cavities and investigate the limits of validity of the photoelastic model that describes light–sound interaction to first-order approximation. Moreover we present some preliminary results on silicon nitride nanobeam phoxonic devices.
Siasos G, Mourouzis K, Oikonomou E, Vavuranakis M, Vogiatzi G, Briasoulis A, Papageorgiou N, Papaioannou TG, Zografos T, Papapanagiotou A, et al.Duration of dual antiplatelet therapy after coronary stenting. Current Pharmaceutical Design [Internet]. 2016;22(29):4583 - 4595. Website
Siasos G, Mourouzis K, Oikonomou E, Vavuranakis M, Vogiatzi G, Briasoulis A, Papageorgiou N, Papaioannou TG, Zografos T, Papapanagiotou A, et al.Duration of dual antiplatelet therapy after coronary stenting. Current Pharmaceutical Design [Internet]. 2016;22(29):4583 - 4595. Website
Siasos G, Mourouzis K, Oikonomou E, Vavuranakis M, Vogiatzi G, Briasoulis A, Papageorgiou N, Papaioannou TG, Zografos T, Papapanagiotou A, et al.Duration of dual antiplatelet therapy after coronary stenting. Current Pharmaceutical Design [Internet]. 2016;22(29):4583 - 4595. Website
The frequency ω dependent storage G′(ω) and loss G″(ω) moduli of star-shaped polystyrene (SPS) molecules of a range of functionalities f and molecular weights per arm Ma were measured under small amplitude oscillatory shear conditions. Star-shaped macromolecules are composed of an inner region, core, where the chain segments are stretched and the “packing” density is higher than that of the outer region, corona. The frequency dependencies of G′(ω) and G″(ω) for low functionality molecules (f<8) with long arms Ma are well described by the model of Milner and McLeish, indicating that the translational dynamics are facilitated by an arm retraction mechanism. With increasing values of f and decreasing Ma the model failsthe arm retraction process is no longer validdue largely to the increasing size of the core in relation to the overall size of the molecule. The molecules exhibit evidence of spatial structural order due to entropic, intermolecular interactions, and the translational dynamics of these molecules occur via a cooperative process, akin to that of soft colloids, for sufficiently large values of f and small Ma. The overall dynamics may be summarized in a diagram delineating different mechanisms that facilitate flow as a function of f and Ma.
Tsimpouki T. E. L. Doctorow (1931-2015). In: Dictionary of Literary Biography 378: Novelists on the American Civil War. Ed. George Parker Anderson. Vol. 378. Gale; 2016. pp. 136–144. Publisher's Version
PURPOSE: The aim of the study was to investigate the effects of low-intensity running performed immediately after lower-body power-training sessions on power development.
METHODS: Twenty young females participated in 6 weeks, 3/week, of either lower body power training (PT) or lower body power training followed by 30 min of low-intensity running (PET) eliciting 60-70 % of maximal heart rate. The following were measured before and after the training period: counter-movement jump, isometric leg press force and rate of force development (RFD), half squat 1-RM, vastus lateralis fiber type composition and cross sectional area, resting intramuscular fiber conduction velocity (MFCV), and heart rate during the modified Bruce treadmill test.
RESULTS: Counter-movement jump height and peak power increased after PT (10.7 ± 6.2 and 12.9 ± 18.7 %, p < 0.05) but not after PET (3.4 ± 7.6 and 5.11 ± 10.94 %, p > 0.05). Maximum isometric force, RFD, and half squat 1-RM increased similarly in both groups. Muscle fiber type composition was not altered in either group. Muscle fiber cross sectional area increased only after PT (17.5 ± 17.4, 14.5 ± 10.4, 20.36 ± 11.3 %, in type I, IIA, and IIX fibers, respectively, p < 0.05). Likewise, mean MFCV increased with PT only (before: 4.53 ± 0.38 m s(-1), after: 5.09 ± 0.39 m s(-1), p = 0.027). Submaximal heart rate during the Bruce treadmill test remained unchanged after PT but decreased after PET.
CONCLUSION: These results suggest that low-intensity running performed after lower-body power training impairs the exercise-induced adaptation in stretch-shortening cycle jumping performance (vertical jump height, peak power), during the first 6 weeks of training, which may be partially linked to inhibited muscle fiber hypertrophy and muscle fiber conduction velocity.
Protopapadakis ED. Earth as a life-raft and ethics as the raft's axe. In: Deretić, Irina / Sorgner, Stefan Lorenz (eds.), From Humanism to Meta-, Post- and Transhumanism? Vol. 8. Beyond Humanism: Trans- and Posthumanism. Frankfurt am Main, Berlin, Bern, Bruxelles, New York, Oxford, Wien: Peter Lang; 2016. pp. 227-241. Publisher's Version
Paraskevis D, Ayouba A, Peeters M. Editorial. Infect Genet Evol. 2016;46:149.
Hydroxymethyl ketones are useful auxiliaries in organic synthesis and are also found in several medicinal agents. N-Heterocyclic carbenes (NHCs) have been used in the literature in order to introduce the hydroxymethyl group into aromatic aldehydes in good yields, but they are not that successful for aliphatic aldehydes. In the present work, the use of microwave irradiation has been efficiently incorporated into this organocatalytic synthesis of aromatic, but more importantly of aliphatic hydroxymethyl ketones that can be used as precursors for medicinally interesting compounds.
Kritikou V. El ámbito geográfico boliviano en Aluvión de Fuego de Óscar Cerruto. In: Europa Balcánica y Los Países de la Cuenca del Mar Negro - Mercosur: Escenarios sociopolíticos, culturales e Integracionistas - Posibilidades y Desafíos. 1st ed. Belgrado: Universidad "John Naisbitt"; 2016. pp. 193-201.Abstract
Resumen: En la novela Aluvión de fuego de Óscar Cerruto se tocan varios aspectos de la sociedad boliviana relacionados con la guerra del Chaco. Se realiza una crítica aguda del sistema político que fue la causa de una guerra absurda y de las injusticias que sufren las capas más desfavorecidas de la población boliviana. El entorno físico juega un papel importante, ya que, aparte de ser el casus belli de la guerra, define la vida y la mentalidad de los personajes, especialmente de los indígenas y los mineros. A través del recorrido del joven protagonista, un rico burgués, por el vasto territorio boliviano se revela una sociedad en crisis debida a la falta de comunicación que caracteriza la clase dominante y los indios. Cerruto cuestiona la situación política y social, mientras que expresa la necesidad de la formación de una conciencia nacional en el pueblo boliviano. Abstract: The Oscar Cerruto´s novel, Aluvión de fuego, presents various aspects of the Bolivian society related to the Chaco War; it condemns the political situation, which is responsible for the absurd war and the injustices the lower social classes suffered. The natural environment setting of the novel is of special importance, because it is the casus belli and defines the life and the whole mentality of the characters, especially of the Indians and miners. The young protagonist´s tour of the vast Bolivian territory, who is a rich bourgeois, shows a society in crisis because of the lack of communication between the ruling class and the Indians. Cerruto questions the political and social situation and expresses the need to form a national consciousness in the Bolivian people.
This paper presents a comparison between e-Learning and traditional learning methods of a University course on Health Informatics domain. A pilot research took place among University students who divided on two learning groups, the e-learners and the traditional learners. A comparison of the examinations' marks for the two groups of students was conducted in order to find differences on students' performance. The study results reveal that the students scored almost the same marks independently of the learning procedure. Based on that, it can be assumed that the e-learning courses have the same effectiveness as the in-classroom learning sessions.
We employ two tight-binding (TB) approaches to systematically study the electronic structure and hole or electron transfer in B-DNA monomer polymers and dimer polymers made up of N monomers (base pairs): (I) at the base-pair level, using the onsite energies of base pairs and the hopping integrals between successive base pairs, i.e., a wire model and (II) at the single-base level, using the onsite energies of the bases and the hopping integrals between neighboring bases, i.e., an extended ladder model since we also include diagonal hoppings. We solve a system of M (matrix dimension) coupled equations [(I) M=N, (II) M=2N] for the time-independent problem, and a system of M coupled first order differential equations for the time-dependent problem. We perform a comparative study of stationary and time-dependent aspects of the two TB variants, using realistic sets of parameters. The studied properties include HOMO and LUMO eigenspectra, occupation probabilities, density of states and HOMO-LUMO gaps as well as mean over time probabilities to find the carrier at each site [(I) base pair or (II) base], Fourier spectra, which reflect the frequency content of charge transfer, and pure mean transfer rates from a certain site to another. The two TB approaches give coherent, complementary aspects of electronic properties and charge transfer in B-DNA monomer polymers and dimer polymers.
This volume brings together a variety of approaches to the different ways in which the role of animals was understood in ancient Greco-Roman myth and religion, across a period of several centuries, from Preclassical Greece to Late Antique Rome. Animals in Greco-Roman antiquity were thought to be intermediaries between men and gods, and they played a pivotal role in sacrificial rituals and divination, the foundations of pagan religion. The studies in the first part of the volume examine the role of the animals in sacrifice and divination. The second part explores the similarities between animals, on the one hand, and men and gods, on the other. Indeed, in antiquity, the behaviour of several animals was perceived to mirror human behaviour, while the selection of the various animals as sacrificial victims to specific deities often was determined on account of some peculiar habit that echoed a special attribute of the particular deity. The last part of this volume is devoted to the study of animal metamorphosis, and to this end a number of myths that associate various animals with transformation are examined from a variety of perspectives.
This study provides new evidence on emerging stock market contagion during the Global Financial crisis (GFC) and the Euro zone Sovereign Debt Crisis (ESDC). Focusing on the three emerging Baltic markets and developed European markets, proxied by the EUROSTOXX50 stock index, we explore asymmetric dynamic conditional correlation dynamics across stable and crisis periods. Empirical evidence indicates a diverse contagion pattern for the Baltic region across the two crises. Latvia and Lithuania were contagious during the GFC, while they were insulated from the adverse effects of the ESDC. On the other hand, Estonia decoupled from the negative consequences during the global turmoil period, but recoupled during the ESDC. The results could be attributed to financial and macroeconomic characteristics of the Baltic countries before and after the turmoil periods and the introduction time of the Euro as a national currency.
Macheras P, Iliadis A. Empirical Models. In: MODELING IN BIOPHARMACEUTICS, PHARMACOKINETICS AND PHARMACODYNAMICS: HOMOGENEOUS AND HETEROGENEOUS APPROACHES, 2ND EDITION. Vol. 30. 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES: SPRINGER; 2016. pp. 161-189.
Collective hybridized plasmon modes, which enable strong magnetooptical coupling and consequent enhanced Faraday effect in three-dimensional periodic assemblies of magnetic dielectric nanoparticles coated with a noble-metal shell, are studied by means of rigorous full electrodynamic calculations using an extension of the layer-multiple-scattering method, in conjunction with the effective-medium approximation. A thorough analysis of relevant photonic dispersion diagrams and transmission spectra provides a consistent explanation of the underlying physical mechanisms to a degree that goes beyond existing interpretation. It is shown that properly designed structures of such composite magnetoplasmonic nanoparticles offer a versatile platform for engineering increased and broadband Faraday rotation.
From 1979 to 1989, ten million tons of phosphogypsum, a waste by-product of the Greek phosphate fertilizer industry, was disposed into an abandoned limestone quarry in Schistos former waste site, Piraeus (Greece). The quarry has been recently closed and remediated using geomembranes and thick soil cover with vegetation. A part of the deposited phosphogypsum has been exposed due to intense rainfall episodes leading to concerns about how could potentially released radioactivity affect the surrounding environment. This study seeks to assess the environmental impact of the phosphogypsum deposited in the Schistos quarry, using laboratory-based $\gamma$-ray spectrometry measurements and geographical information systems. Radioactivity concentrations were mapped onto spatial-data to yield a spatial-distribution of radioactivity in the area. The data indicate elevated 226Ra concentrations in a specific area on the steep south-eastern cliff of the remediated waste site that comprises uncovered phosphogypsum and is known to be affected by local weather conditions. 226Ra concentrations range from 162 to 629 Bq/kg, with an average activity being on the low side, compared to the global averages for phosphogypsum. Nevertheless, the low environmental risk may be minimized by remediating this area with geomembranes and thick soil cover with vegetation, a technique, which has worked successfully over the remainder of the remediated quarry.
{The main objective of this work is the assessment of the annual number of hospital admissions for respiratory disease (HARD) due to the exposure to inhalable particulate matter (PM10), within the greater Athens area (GAA), Greece. Towards this aim, the time series of the particulate matter with aerodynamic diameter less than 10 mu m (PM10) recorded in six monitoring stations located in the GAA, for a 13-year period 2001-2013, is used. In this study AirQ2.2.3 software developed by the WHO, was used to evaluate adverse health effects by PM10 in the GAA during the examined period. The results show that, the mean annual HARD cases per 100,000 inhabitants ranged between 20 (suburban location) and 40 (city centre location). Approximately 70 % of the annual HARD cases are due to city centre residents. In all examined locations, a declining trend in the annual number of HARD cases is appeared. Moreover, a strong relation between the annual number of HARD cases and the annual number of days exceeding the European Union daily PM10 threshold value was found.}
In this paper a re-analysis of previous research concerning an uplifted tidal notch developed near the modern harbor of Poros (eastern Cephalonia Island, Ionian Sea, Greece) is undertaken. According to radiocarbon dating, this notch was active between the 4th–6th century AD and 1953 AD, i.e. for at least 1450 years. Recent measurements have shown that the inward depth of the notch profile at well preserved sites is 93 cm. This permits an estimate of the average rate of intertidal bioerosion to 0.64 mm/a for this time period.
PURPOSE: Programmed death-ligand 1 (PD-L1; also known as CD274 or B7-H1) expression represents a mechanism of immune escape for cancer. Our purpose was to characterize tumor PD-L1 expression and associated T-cell infiltration in primary laryngeal squamous cell carcinomas (SCC). EXPERIMENTAL DESIGN: A well-annotated cohort of 260 operable primary laryngeal SCCs [formalin-fixed paraffin-embedded (FFPE) specimens] was morphologically characterized for stromal tumor-infiltrating lymphocytes (TIL), on hematoxylin/eosin-stained whole sections and for PD-L1 mRNA expression by qRT-PCR in FFPE specimens. For PD-L1 protein expression, automated quantitative protein analysis (AQUA) was applied on tissue microarrays consisting of two cores from these tumors. In addition, PD-L1 mRNA expression in fresh-frozen tumors and normal adjacent tissue specimens was assessed in a second independent cohort of 89 patients with primary laryngeal SCC. RESULTS: PD-L1 mRNA levels were upregulated in tumors compared with surrounding normal tissue (P = 0.009). TILs density correlated with tumor PD-L1 AQUA levels (P = 0.021). Both high TILs density and high PD-L1 AQUA levels were significantly associated with superior disease-free survival (DFS; TILs: P = 0.009 and PD-L1: P = 0.044) and overall survival (OS; TILs: P = 0.015 and PD-L1: P = 0.059) of the patients and retained significance in multivariate analysis. CONCLUSIONS: Increased TILs density and PD-L1 levels are associated with better outcome in laryngeal squamous cell cancer. Assessment of TILs and PD-L1 expression could be useful to predict response to immune checkpoint inhibitors.
Maintenance and accurate propagation of the genetic material are key features for physiological development and wellbeing. The replication licensing machinery is crucial for replication precision as it ensures that replication takes place once per cell cycle. Thus, the expression status of the components comprising the replication licensing apparatus is tightly regulated to avoid re-replication; a form of replication stress that leads to genomic instability, a hallmark of cancer. In the present review we discuss the mechanistic basis of replication licensing deregulation, which leads to systemic effects, exemplified by its role in carcinogenesis and a variety of genetic syndromes. In addition, new insights demonstrate that above a particular threshold, the replication licensing factor Cdc6 acts as global transcriptional regulator, outlining new lines of exploration. The role of the putative replication licensing factor ChlR1/DDX11, mutated in the Warsaw Breakage Syndrome, in cancer is also considered. Finally, future perspectives focused on the potential therapeutic advantage by targeting replication licensing factors, and particularly Cdc6, are discussed.
Silicoflagellate abundance, vertical distribution and morphology were studied during spring (March 2014) at three sampling stations locatedin the Northeast Aegean Sea adjacent to the Dardanelles Strait and characterized by a variable influx of cold, low-salinity Black Sea water.The silicoflagellate assemblage was dominated by Dictyocha stapedia and Stephanocha speculum with minor contribution of D. aculeata andOctactis pulchra. While specimens of D. stapedia were represented by the typical morphologies described in other areas of the Mediterranean Sea,populations of S. speculum displayed peculiar characters: they were large, predominantly 7-sided, with a small apical ring as well as apical ringspines, concave basal ring sides and non-rotated apical structure. Some of these features have been described for S. speculum at high latitudes, butthe combined characters make these specimens slightly different from the high latitude populations. Similar morphologies have been observed inthe western Black Sea, thus we can infer that the peculiar specimens detected in the Northeast Aegean are associated with the influx of Black Seawater masses.
The Fermi surfaces and Elliott-Yafet spin-mixing parameter (EYP) of several elemental metals are studied by ab initio calculations. We focus first on the anisotropy of the EYP as a function of the direction of the spin-quantization axis {[}B. Zimmermann et al., Phys. Rev. Lett. 109, 236603 (2012)]. We analyze in detail the origin of the gigantic anisotropy in 5d hcp metals as compared to 5d cubic metals by band structure calculations and discuss the stability of our results against an applied magnetic field. We further present calculations of light (4d and 3d) hcp crystals, where we find a huge increase of the EYP anisotropy, reaching colossal values as large as 6000% in hcp Ti. We attribute these findings to the reduced strength of spin-orbit coupling, which promotes the anisotropic spin-flip hot loops at the Fermi surface. In order to conduct these investigations, we developed an adapted tetrahedron-based method for the precise calculation of Fermi surfaces of complicated shape and accurate Fermi-surface integrals within the full-potential relativistic Korringa-Kohn-Rostoker Green function method.
There are limited data on fetuin-A, soluble leptin receptor (sOB-R) and free leptin index (FLI) in patients with chronic lymphocytic leukemia (CLL). The aim of this study was to compare circulating fetuin-A, sOB-R levels and FLI between 95 patients with CLL and 95 matched controls, as well as among different stages of CLL. Circulating fetuin-A was significantly lower in cases than controls (241.9 ± 99.2 vs. 288.8 ± 127.7 μg/mL; p = 0.005). Although circulating sOB-R levels were similar between groups, FLI was lower in cases than controls (0.45 ± 0.42 vs. 0.67 ± 0.57; p = 0.003). Furthermore, lower fetuin-A or FLI, but not sOB-R, were independently associated with CLL (p < 0.05), particularly among overweight/obese individuals. Fetuin-A, s-OB-R and FLI were similar between different stages of CLL severity, or between symptomatic and asymptomatic disease. In conclusion, circulating fetuin-A and FLI, but not sOB-R, were lower in patients with CLL than controls, a finding warranting further investigation.
A number of software applications for the practice of the singing voice have been introduced the last decades, but all of them are limited to equal tempered scales. In this work, we present the design and development of FONASKEIN, a novel modular interactive software application for the practice of singing voice in real time and with visual feedback for both equal and non-equal tempered scales. Details of the Graphical User Interface of FONASKEIN are given, along with its architecture. The evaluation results of FONASKEIN in a pilot experiment with eight participants and with four songs in various musical scales showed its positive effect in practice of the singing voice in all cases.
Saronikos Gulf, including the industrial zone of Elefsis Bay and the Port of Piraeus, is one of the most anthropogenically impacted coastal regions of Greece. Distinct assemblages of benthic foraminifers in sediment samples, collected from this gulf in February 2012, defined three zones that reflect abiotic parameters of the sediments (e.g., organic carbon, metal content). A low-diversity assemblage, dominated by stress-tolerantAmmonia tepida and Bulimina spp., was characteristic of samples from Elefsis Bay. Samples from the western and central part of Saronikos Gulf were the most variable with respect to both abiotic parameters and the foraminiferal assemblage, characterized by a mix of stress-tolerant and more sensitive taxa, especially Bolivina spp. andNonion fabum. Samples from the coast of Salamis and at the eastern sector of the gulf were characterized by a diverse assemblage that included Peneroplis pertusus, miliolids, and a variety of small, epiphytic rotaliid taxa. A new biotic index, the Foram Stress Index (FSI), is based on the relative percentages of two ecological groups of benthic foraminiferal species, grouped according to their tolerance/sensitivity to organic matter enrichment and weighted proportionately to obtain a formula to define five ecological-status classes. The FSI produced three rankings for these samples (Poor, Moderate and Good), that strongly correlate with the macroinvertebrate-classification tool known as the BENTIX Index. The FSI provides a new tool to assess sediment or substrata quality based upon the benthic foraminiferal assemblages, which are a significant component of living meiobenthic communities that are generally not considered in most biotic benthic indices.
Saronikos Gulf, including the industrial zone of Elefsis Bay and the Port of Piraeus, is one of the most anthropogenically impacted coastal regions of Greece. Distinct assemblages of benthic foraminifers in sediment samples, collected from this gulf in February 2012, defined three zones that reflect abiotic parameters of the sediments (e.g., organic carbon, metal content). A low-diversity assemblage, dominated by stress-tolerantAmmonia tepida and Bulimina spp., was characteristic of samples from Elefsis Bay. Samples from the western and central part of Saronikos Gulf were the most variable with respect to both abiotic parameters and the foraminiferal assemblage, characterized by a mix of stress-tolerant and more sensitive taxa, especially Bolivina spp. andNonion fabum. Samples from the coast of Salamis and at the eastern sector of the gulf were characterized by a diverse assemblage that included Peneroplis pertusus, miliolids, and a variety of small, epiphytic rotaliid taxa. A new biotic index, the Foram Stress Index (FSI), is based on the relative percentages of two ecological groups of benthic foraminiferal species, grouped according to their tolerance/sensitivity to organic matter enrichment and weighted proportionately to obtain a formula to define five ecological-status classes. The FSI produced three rankings for these samples (Poor, Moderate and Good), that strongly correlate with the macroinvertebrate-classification tool known as the BENTIX Index. The FSI provides a new tool to assess sediment or substrata quality based upon the benthic foraminiferal assemblages, which are a significant component of living meiobenthic communities that are generally not considered in most biotic benthic indices.
Macheras P, Iliadis A. Fractional Pharmacokinetics. In: MODELING IN BIOPHARMACEUTICS, PHARMACOKINETICS AND PHARMACODYNAMICS: HOMOGENEOUS AND HETEROGENEOUS APPROACHES, 2ND EDITION. Vol. 30. 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES: SPRINGER; 2016. pp. 211-225.
In this paper, we revisit the discovery of argon by Lord Rayleigh and William Ramsay. We argue that to understand historically how argon was detected, conceptualized, and accommodated into chemical knowledge we need to take into account the philosophical insight that scientific discovery is often an extended process. One of argon’s most intriguing properties was that it did not react with other elements. Reactivity, however, had been a constitutive property of elements. Thus, the discovery of argon could not have been accepted by chemists without a reconceptualization of ‘element’. Furthermore, there were difficulties with the accommodation of argon in the Periodic table, because argon appeared to undermine the conception of matter that underlay the Periodic table. The discovery of argon was complete only after those conceptual difficulties had been removed. This is why it has to be understood as an extended process, rather than as an event. Furthermore, we will suggest that some of the factors that complicated the discovery of argon were related to the legitimization of physical techniques of investigation in chemistry and the emergence of physical chemistry.
Context. At about 1000 days after the launch of Gaia we present the first Gaia data release, Gaia DR1, consisting of astrometry and photometry for over 1 billion sources brighter than magnitude 20.7. Aims: A summary of Gaia DR1 is presented along with illustrations of the scientific quality of the data, followed by a discussion of the limitations due to the preliminary nature of this release. Methods: The raw data collected by Gaia during the first 14 months of the mission have been processed by the Gaia Data Processing and Analysis Consortium (DPAC) and turned into an astrometric and photometric catalogue. Results: Gaia DR1 consists of three components: a primary astrometric data set which contains the positions, parallaxes, and mean proper motions for about 2 million of the brightest stars in common with the Hipparcos and Tycho-2 catalogues - a realisation of the Tycho-Gaia Astrometric Solution (TGAS) - and a secondary astrometric data set containing the positions for an additional 1.1 billion sources. The second component is the photometric data set, consisting of mean G-band magnitudes for all sources. The G-band light curves and the characteristics of 3000 Cepheid and RR Lyrae stars, observed at high cadence around the south ecliptic pole, form the third component. For the primary astrometric data set the typical uncertainty is about 0.3 mas for the positions and parallaxes, and about 1 mas yr-1 for the proper motions. A systematic component of 0.3 mas should be added to the parallax uncertainties. For the subset of 94 000 Hipparcos stars in the primary data set, the proper motions are much more precise at about 0.06 mas yr-1. For the secondary astrometric data set, the typical uncertainty of the positions is 10 mas. The median uncertainties on the mean G-band magnitudes range from the mmag level to 0.03 mag over the magnitude range 5 to 20.7. Conclusions: Gaia DR1 is an important milestone ahead of the next Gaia data release, which will feature five-parameter astrometry for all sources. Extensive validation shows that Gaia DR1 represents a major advance in the mapping of the heavens and the availability of basic stellar data that underpin observational astrophysics. Nevertheless, the very preliminary nature of this first Gaia data release does lead to a number of important limitations to the data quality which should be carefully considered before drawing conclusions from the data.
Collaboration G, Prusti T, de Bruijne JHJ, Brown AGA, Vallenari A, Babusiaux C, Bailer-Jones CAL, Bastian U, Biermann M, Evans DW, et al.The Gaia mission. [Internet]. 2016;595:A1. WebsiteAbstract
Gaia is a cornerstone mission in the science programme of the EuropeanSpace Agency (ESA). The spacecraft construction was approved in 2006, following a study in which the original interferometric concept was changed to a direct-imaging approach. Both the spacecraft and the payload were built by European industry. The involvement of the scientific community focusses on data processing for which the international Gaia Data Processing and Analysis Consortium (DPAC) was selected in 2007. Gaia was launched on 19 December 2013 and arrived at its operating point, the second Lagrange point of the Sun-Earth-Moon system, a few weeks later. The commissioning of the spacecraft and payload was completed on 19 July 2014. The nominal five-year mission started with four weeks of special, ecliptic-pole scanning and subsequently transferred into full-sky scanning mode. We recall the scientific goals of Gaia and give a description of the as-built spacecraft that is currently (mid-2016) being operated to achieve these goals. We pay special attention to the payload module, the performance of which is closely related to the scientific performance of the mission. We provide a summary of the commissioning activities and findings, followed by a description of the routine operational mode. We summarise scientific performance estimates on the basis of in-orbit operations. Several intermediate Gaia data releases are planned and the data can be retrieved from the Gaia Archive, which is available through the Gaia home page. http://www.cosmos.esa.int/gaia
Multiciliated cells are terminally differentiated, post-mitotic cells that form hundreds of motile cilia on their apical surface. Defects in multiciliated cells lead to disease, including mucociliary clearance disorders that result from ciliated cell disfunction in airways. The pathway controlling multiciliogenesis, however, remains poorly characterized. We showed that GemC1, previously implicated in cell cycle control, is a central regulator of ciliogenesis. GemC1 is specifically expressed in ciliated epithelia. Ectopic expression of GemC1 is sufficient to induce early steps of multiciliogenesis in airway epithelial cells ex vivo, upregulating McIdas and FoxJ1, key transcriptional regulators of multiciliogenesis. GemC1 directly transactivates the McIdas and FoxJ1 upstream regulatory sequences, and its activity is enhanced by E2F5 and inhibited by Geminin. GemC1-knockout mice are born with airway epithelia devoid of multiciliated cells. Our results identify GemC1 as an essential regulator of ciliogenesis in the airway epithelium and a candidate gene for mucociliary disorders.
Macheras P, Iliadis A. The Geometry of Nature. In: MODELING IN BIOPHARMACEUTICS, PHARMACOKINETICS AND PHARMACODYNAMICS: HOMOGENEOUS AND HETEROGENEOUS APPROACHES, 2ND EDITION. Vol. 30. 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES: SPRINGER; 2016. pp. 3-14.
The littoral region of Alexandria, east of Silsileh (the eastern promontory of the Eastern Harbor) to Montazah promontory was investigated combining archaeological and geomorphological evidence in order to better understand the subsidence of the coastal zone. The coastal zone is rich in archaeological and geomorphological features able to provide insights into the evolution of the coastline and the relative sea level changes. Our study has revealed a continuous subsidence of the coastal zone, owed to various contributing processes, while further research is required to decipher the coastal evolution of this littoral.
Women are more likely to develop depression during childbearing years with up to 20% of women suffering from depression during pregnancy and in the postpartum period. Increased prevalence of depression during the perinatal period has resulted in frequent selective serotonin reuptake inhibitor (SSRI) antidepressant treatment; however the effects of such medications on the maternal brain remain limited. Therefore, the aim of the present study is to investigate the effects of the SSRI medication, fluoxetine, on neurobiological differences in the maternal brain. To model aspects of maternal depression, gestational stress was used. Sprague-Dawley rat dams were exposed to either gestational stress and/or fluoxetine (5mg/kg/day) to form the following four groups: 1. Control+Vehicle, 2. Stress+Vehicle, 3. Control+Fluoxetine, and 4. Stress+Fluoxetine. At weaning maternal brains were collected. Main findings show that gestational stress alone increased synaptophysin and serotonin metabolism in the cingulate cortex2 region of the cortex while fluoxetine treatment after stress normalized these effects. In the hippocampus, fluoxetine treatment, regardless of gestational stress exposure, decreased both global measures of methylation in the dentate gyrus, as measured by Dnmt3a immunoreactivity, as well as serotonin metabolism. No further changes in synaptophysin, PSD-95, or Dnmt3a immunoreactivity were seen in the cortical or hippocampal areas investigated. These findings show that gestational stress and SSRI medication affect the neurobiology of the maternal brain in a region-specific manner. This work adds to a much needed area of research aimed at understanding neurobiological changes associated with maternal depression and the role of SSRI treatment in altering these changes in the female brain.
Women are more likely to develop depression during childbearing years with up to 20% of women suffering from depression during pregnancy and in the postpartum period. Increased prevalence of depression during the perinatal period has resulted in frequent selective serotonin reuptake inhibitor (SSRI) antidepressant treatment; however the effects of such medications on the maternal brain remain limited. Therefore, the aim of the present study is to investigate the effects of the SSRI medication, fluoxetine, on neurobiological differences in the maternal brain. To model aspects of maternal depression, gestational stress was used. Sprague-Dawley rat dams were exposed to either gestational stress and/or fluoxetine (5mg/kg/day) to form the following four groups: 1. Control+Vehicle, 2. Stress+Vehicle, 3. Control+Fluoxetine, and 4. Stress+Fluoxetine. At weaning maternal brains were collected. Main findings show that gestational stress alone increased synaptophysin and serotonin metabolism in the cingulate cortex2 region of the cortex while fluoxetine treatment after stress normalized these effects. In the hippocampus, fluoxetine treatment, regardless of gestational stress exposure, decreased both global measures of methylation in the dentate gyrus, as measured by Dnmt3a immunoreactivity, as well as serotonin metabolism. No further changes in synaptophysin, PSD-95, or Dnmt3a immunoreactivity were seen in the cortical or hippocampal areas investigated. These findings show that gestational stress and SSRI medication affect the neurobiology of the maternal brain in a region-specific manner. This work adds to a much needed area of research aimed at understanding neurobiological changes associated with maternal depression and the role of SSRI treatment in altering these changes in the female brain.
A concept realizing giant spin Nernst effect in nonmagnetic metallic films is introduced. It is based on the idea of engineering an asymmetric energy dependence of the longitudinal and transverse electrical conductivities, as well as a pronounced energy dependence of the spin Hall angle in the vicinity of the Fermi level by the resonant impurity states at the Fermi level. We employ an analytical model and demonstrate the emergence of a giant spin Nernst effect in Ag(111) films using ab initio calculations combined with the Boltzmann approach for transport properties arising from skew scattering off impurities.
Human immunodeficiency virus type 1 (HIV-1) was discovered in the early 1980s when the virus had already established a pandemic. For at least three decades the epidemic in the Western World has been dominated by subtype B infections, as part of a sub-epidemic that traveled from Africa through Haiti to United States. However, the pattern of the subsequent spread still remains poorly understood. Here we analyze a large dataset of globally representative HIV-1 subtype B strains to map their spread around the world over the last 50years and describe significant spread patterns. We show that subtype B travelled from North America to Western Europe in different occasions, while Central/Eastern Europe remained isolated for the most part of the early epidemic. Looking with more detail in European countries we see that the United Kingdom, France and Switzerland exchanged viral isolates with non-European countries than with European ones. The observed pattern is likely to mirror geopolitical landmarks in the post-World War II era, namely the rise and the fall of the Iron Curtain and the European colonialism. In conclusion, HIV-1 spread through specific migration routes which are consistent with geopolitical factors that affected human activities during the last 50years, such as migration, tourism and trade. Our findings support the argument that epidemic control policies should be global and incorporate political and socioeconomic factors.
Τhis lavishly illustrated book surveys Greek archaeology from the collapse of the Mycenaean palaces to the subordination of the last Hellenistic kingdoms to Rome. Its aim is to study Greek art through the material record, and against its cultural and social backdrop. The book's target audience is archaeology and art students, as well as anyone interested in Greek art and culture. Through concise, systematic covering of the main categories of classical monuments, the reader is taken to a tour of ancient Greece along the most spectacular period in its history, the 1st millennium BC. Architecture and city planning, sculpture, painting, pottery, metallurgy, jewelry, and numismatics are some of the areas covered.
Kamberidou I, Chroni S. The Greek Experience: Outstanding Women in the Social Space of Sport. In: Inspirational Women in Europe: making a difference in Physical Education, Sport and Dance. Juiz de Fora, Brazil.: Rosa Diketmüller (editor). Juiz de Fora : NGIME/UFJF, 2016. 254 p. (IAPESGW Continent Series). Publication of the International Association of Physical Education and Sport for Girls and Women (IAPESGW), ISBN 978-85-67380-55-1; 2016. pp. 224–242.Abstract
The Voices of Six Inspirational Greek Women in Sport: What inspired them to take that leap; the Obstacles they faced; how they moved forward and Tips for Success. Many inspirational and outstanding women have made a difference in the lives ofgirls and women in sport, physical education (PE) and physical activity in Greece,despite their invisibility in the mainstream media, the life stories of which would needvolumes. They succeeded in making a difference while respecting and celebratingdiversity with regard to gender, ethnicity, culture, disability, age and sexualorientation. Beginning with a brief discussion on the underrepresentation of women’ssports and the female athlete in the Greek media, this chapter shares the contributionsof some inspiring and motivating Greek women in sport whose achievements havebeen excluded from the country’s mainstream media. It is through six in-depthinterviews and follow-up meetings that we learn how these pioneers influenced thelives of sporting girls and women by daring to disregard social barriers and spreadawareness. We conclude the chapter with tips from these successful, namelyinspirational women, who all agree that success requires ethos and taking that leap.http://www.ngime.ufjf.br/wp-content/uploads/Europa_opt.pdf
Kostis PC, Kafka KI, Valsamis DG. The Greek Growth Decoupling. In: A New Growth Model for the Greek Economy. Palgrave Macmillan {US}; 2016. pp. 33–57. Website
The coinfection of Hepatitis B virus (HBV) and human immunodeficiency virus (HIV) has been associated with increased death rates. However, the relevant research has mostly relied on serologic HBV testing [HBV surface antigen (HBsAg)]. The aim of this work was to explore the relationship of HBV viraemia with overall mortality among HIV/HBV coinfected individuals. The analysis included 1,609 HIV seropositives of a previously described cohort (1984-2003) with limited exposure to tenofovir (12%) and a median follow-up of approximately 5 years. Those with persistent expression of HBsAg were further tested for HBV-DNA. The data were analyzed using Poisson regression models. Totally, 101 participants were chronic carriers of HBsAg (6.28%). Of these, 81 were tested for HBV-DNA. The median HBV-DNA levels were 3.81 log (base-10) International Units (IU)/ml. A third (31%) of those tested for HBV-DNA had received tenofovir. Before developing acquired immune deficiency syndrome (AIDS), the adjusted incidence rate ratio (IRR) for all-cause mortality of coinfected patients with HBV viraemia above the median value versus the HIV monoinfected group was 3.44 [95% confidence interval (CI): 1.05-11.27]. Multivariable regressions in the coinfected group only (n = 81) showed that one log-10 increase in HBV-DNA levels was associated with an elevated risk for death (IRR: 1.24, 95%CI: 1.03-1.49). HBV-DNA levels predict overall mortality in the setting of HIV/HBV coinfection, especially during the period before developing AIDS, and could thus help prioritize needs and determine the frequency of medical monitoring.
BACKGROUND: Most of the HCV transmission the recent years in Greece was among IDUs. Our aim was to estimate the prevalence of HCV genotypes and to investigate the patterns of HCV dispersal among IDUs in Athens using current state of the art molecular epidemiology methods.
METHODS: HCV sequences were determined from 238 HIV-negative IDUs collected on the basis of the "ARISTOTLE" prevention program carried out in Athens between 2012 and 2013. Phylogenetic trees were inferred on HCV sequences isolated from IDUs in Athens for the most prevalent HCV clades (subtypes 1a and 3a). Phylogenetic analysis was performed by Neighbor-Joining and Bayesian methods using GTR+G as nucleotide substitution model. HCV dispersal patterns were estimated using as references, all globally available HCV sequences for subtypes 1a and 3a.
RESULTS: The prevalence of HCV subtypes was: 3a (59.2%), 1a (21.9%), 4 (13.0%), 1b (5.4%) and 2 (0.5%). Phylogenetic analyses revealed that most sequences (63.5%) οf subtypes 1a and 3a fell within IDU-specific monophyletic groups. The proportion of sequences in monophyletic clades was similar for subtype 3a (62.9%) and 1a (65.3%). For the latter group, monophyletic clades were smaller in size. Multivariable logistic regression analyses showed that monophyletic clustering was marginally associated recent onset of injecting ([AOR]=1.44; 95% CI (0.97-2.13), p=0.068).
CONCLUSIONS: The high proportions of HCV sequences within IDU-specific monophyletic clusters suggest that transmissions occurred locally among IDUs in Greece. The numerous clusters for both 1a and 3a provide evidence that both sub-epidemics were the result of multiple introductions among the IDUs. Higher regional clustering was probably associated with a more recent onset of drug use.
Kopanias K, Fox S. Headshaping at Tell NaderMina M, Papadatos Y, Triantaphyllou S. Embodied Identities In The Prehistoric Eastern Mediterranean: Convergence Of Theory And Practices. Conference hosted by the University of Cyprus, 10-12 April 2012, Nicosia, Cyprus [Internet]. 2016:153-159. Publisher's Versionpaper_2016_headshaping_at_tell_nader.pdf
Objective:The objective of this study was to investigate the relationship between classroom psychological climate and the physical and sedentary behaviour of primary school students after the implementation of an innovative education programme regarding nutrition and physical activity.Design:Randomised controlled trial.Setting:Study participants were 729 students, aged 8?10?years, in the third and fourth grade of 30 public primary schools in the Athens Metropolitan Area.Methods:Students were randomly assigned to three study groups: an Intensive Intervention Group (IIG) that underwent an intensive nutrition and physical activity education programme delivered by specialised personnel and teachers, an Intervention Group (IG) that underwent a less intensive programme delivered by their regular teacher and a Control Group (CG) that received no instruction. Classroom Psychological Climate (CPC) was measured in all groups, and the data regarding physical activity and sedentary lifestyle habits, such as the time spent viewing TV or video games (screen time), were recorded.Results:Friction declined and satisfaction increased significantly after the intervention in the IG compared with the CG. There was no significant difference in physical activity and screen time between the groups. Daily screen time was positively associated with increased friction, which is a measure of conflicts between students in the school environment.Conclusion:A school nutrition and physical activity education programme was shown to decrease friction by decreasing daily screen time and increasing outdoor activities. These findings also suggest that teachers alone may be more effective in delivering optional health education programmes than specialised personnel and instructors.
Across-sectional survey was designed to determine health professionals' awareness and usage of online evidence retrieval systems in clinical practice. A questionnaire was used to measure professionals' behavior and utilization of online evidences, as well as, reasons and barriers on information retrieval. 439 nurses and physicians from public and private hospitals in Greece formulate the study's sample. The two most common reasons that individuals are using online information systems were for writing scientific manuscripts or filling a knowledge gap. A positive correlation was found between participants with postgraduate studies and information system usage. The majority of them (90,6%) believe that online information systems improves patient care and 67,6% of them had their own experiences on this. More support is needed to nurses and physicians in order to use the online evidence and as a result to improve the provided care and practices.
This paper investigates the relationship between the volatility of Volume Synchronized Probability of Informed Trading (VPIN) and future short-term volatility of stock returns. We construct a transaction-signed version of VPIN (TR-VPIN) based on tick by tick data on securities traded in the Athens Stock Exchange (ASE) during the Greek sovereign debt crisis. The results show a positive and statistically significant correlation between the volatility of TR-VPIN and future short-term volatility for securities that are exposed to asymmetric information during the period under examination. This evidence expands the existent literature which shows that the absolute order imbalance forecasts absolute returns, suggesting that TR-VPIN is a real-time informative indicator of the Probability of Informed Trading (PIN) in the high frequency domain. Further, the long-range dependence between the conditional volatilities of TR-VPIN and stock returns becomes more significant as we move towards securities which display stronger long memory. This is perfectly in line with the recent empirical evidence in microstructure literature that large past shocks of flow toxicity can lead to volatility through liquidity shortages.
Combined micropaleontological and geochemical analyses of the high-sedimentation gravity core M-4G provided new centennial-scale paleoceanographic data for sapropel S1 deposition in the NE Aegean Sea during the Holocene Climatic Optimum. Sapropel layer S1a (10.2–8.0 ka) was deposited in dysoxic to oxic bottom waters characterized by a high abundance of benthic foraminiferal species tolerating surface sediment and/or pore water oxygen depletion (e.g.,Chilostomella mediterranensis, Globobulimina affinis), and the presence of Uvigerina mediterranea, which thrives in oxic mesotrophic-eutrophic environments. Preservation of organic matter (OM) is inferred based on high organic carbon as well as loliolide and isololiolide contents, while the biomarker record and the abundances of eutrophic planktonic foraminifera document enhanced productivity. High inputs of terrigenous OM are attributed to north Aegean borderland riverine inputs. Both alkenone-based sea surface temperatures (SSTs) and δO18 G. bulloides records indicate cooling at 8.2 ka (S1a) and ~7.8 ka (S1 interruption). Sapropelic layer S1b (7.7–6.4 ka) is characterized by rather oxic conditions; abundances of foraminiferal species tolerant to oxygen depletion are very low compared with the U. mediterranea rise. Strongly fluctuating SSTs demonstrate repeated cooling and associated dense water formation, with a major event at 7.4 ka followed by cold spells at 7.0, 6.8, and 6.5 ka. The prominent rise of the carbon preference index within the S1b layer indicates the delivery of less degraded terrestrial OM. The increase of algal biomarkers, labile OM-feeding foraminifera and eutrophic planktonic species pinpoints an enhanced in situ marine productivity, promoted by more efficient vertical convection due to repeated cold events. The associated contributions of labile marine OM along with fresher terrestrial OM inputs after ~7.7 ka imply sources alternative/additional to the north Aegean riverine borderland sources for the influx of organic matter in the south Limnos Basin, plausibly related to the inflow of highly productive Marmara/Black Sea waters.
Combined micropaleontological and geochemical analyses of the high-sedimentation gravity core M-4G provided new centennial-scale paleoceanographic data for sapropel S1 deposition in the NE Aegean Sea during the Holocene Climatic Optimum. Sapropel layer S1a (10.2–8.0 ka) was deposited in dysoxic to oxic bottom waters characterized by a high abundance of benthic foraminiferal species tolerating surface sediment and/or pore water oxygen depletion (e.g.,Chilostomella mediterranensis, Globobulimina affinis), and the presence of Uvigerina mediterranea, which thrives in oxic mesotrophic-eutrophic environments. Preservation of organic matter (OM) is inferred based on high organic carbon as well as loliolide and isololiolide contents, while the biomarker record and the abundances of eutrophic planktonic foraminifera document enhanced productivity. High inputs of terrigenous OM are attributed to north Aegean borderland riverine inputs. Both alkenone-based sea surface temperatures (SSTs) and δO18 G. bulloides records indicate cooling at 8.2 ka (S1a) and ~7.8 ka (S1 interruption). Sapropelic layer S1b (7.7–6.4 ka) is characterized by rather oxic conditions; abundances of foraminiferal species tolerant to oxygen depletion are very low compared with the U. mediterranea rise. Strongly fluctuating SSTs demonstrate repeated cooling and associated dense water formation, with a major event at 7.4 ka followed by cold spells at 7.0, 6.8, and 6.5 ka. The prominent rise of the carbon preference index within the S1b layer indicates the delivery of less degraded terrestrial OM. The increase of algal biomarkers, labile OM-feeding foraminifera and eutrophic planktonic species pinpoints an enhanced in situ marine productivity, promoted by more efficient vertical convection due to repeated cold events. The associated contributions of labile marine OM along with fresher terrestrial OM inputs after ~7.7 ka imply sources alternative/additional to the north Aegean riverine borderland sources for the influx of organic matter in the south Limnos Basin, plausibly related to the inflow of highly productive Marmara/Black Sea waters.
PURPOSE: During the last three decades, the number of devices that emit non-ionizing electromagnetic radiation (EMR) at the wireless communication spectrum has rapidly increased and possible effects on living organisms have become a major concern. The purpose of this study was to investigate the effects of radiofrequency EMR emitted by a widely used wireless communication device, namely the Digital Enhanced Communication Telephony (DECT) base, on the immune responses of the Aegean wall lizard (Podarcis erhardii).
MATERIALS AND METHODS: Adult male lizards were exposed 24 h/day for 8 weeks to 1880-1900 MHz DECT base radiation at average electric field intensity of 3.2 V/m. Immune reactivity was assessed using the phytohemagglutinin (PHA) skin swelling and mixed lymphocyte reaction (MLR) tests.
RESULTS: Our results revealed a noticeable suppression (approximately 45%) of inflammatory responses in EMR-exposed lizards compared to sham-exposed animals. T cell-mediated responses were marginally affected.
CONCLUSION: Daily radiofrequency EMR exposure seems to affect, at least partially, the immunocompetence of the Aegean wall lizard.
{The goal of this study is to quantify the impact of airborne coarse particles between 2.5 and 80 mu m (PM2.5-PM80) on hospital admissions for respiratory diseases, acquired from the two main hospitals in Heraklion, Crete Island. The atmospheric coarse particles were collected in Heraklion city from November 18, 2011 to May 31, 2013, using the Sigma-2 passive sampler technique. Further, the Scanning Electron Microscopy (SEM), was utilized to identify the qualitative structure of PMs. On one hand, we applied Generalized Addictive Models (GAMS) in order to assess the impact of coarse particles on respiratory diseases. The findings of the analysis revealed that the highest estimates were 7.3 % (Cl: 1.00-1.01) and 7.1 % (Cl: 1.00-1.01) increases in weekly respiratory admissions associated with an increase of 10 mu g m(-3) with respect to coarse particles between 10 and 20 mu m, for men and women, respectively. On the other hand, using SEM technique, the PMs were identified by means of their chemical composition. It is worth noting the presence of Rutile (a mineral composed primarily by Titanium Dioxide), which was found in our samples with possible origin from Saharan desert, causing adverse respiratory problems.}
The ability of vertebrates to evolve different defence strategies in response to varying parasitism regimes remains poorly understood. Hosts may adopt two different strategies to defend themselves against parasites: tolerance (hosts alleviate the negative fitness consequences of parasite infection) and resistance (hosts strengthen their immune response as parasite burden increases). Both strategies are effective, but fitness has been reported to decline faster in less-tolerant individuals. Here, we assessed the number of splenocytes and the cell-mediated response (proxies for resistance) and body condition (a proxy for tolerance) in four populations of a Greek endemic lizard (Podarcis gaigeae), each exposed to different infection risks (defined as the cumulative effect of parasite burden and duration of exposure). We anticipated that populations with heavy parasite burden would enhance the efficacy of their immune response (resistance) compared to lizards deriving from parasite-poor habitats. We also predicted that populations with longer exposure to parasites would be adopted and be more tolerant. Each factor (duration of exposure and parasite burden) had a distinct effect on the immune response, and thus, our results were rather complicated. Lizards with heavy parasite burden and aperiodic exposure demonstrated resistance, whereas lizards with heavy parasite burden and chronic exposure were more tolerant. Populations with low parasite burden and minimal exposure were more resistant. Our results suggest that the development of some immunological strategies may be differentiated under different infection risks, even within the same species.
We show by first-principles calculations that the skew-scattering anomalous Hall and spin Hall angles of L1(0)-ordered FePt drastically depend on different types of disorder. A different sign of the anomalous Hall angle is obtained when slightly deviating from the stoichiometric ratio towards the Fe-rich side as compared to the Pt-rich side. For stoichiometric samples, short-range ordering of defects has a profound effect on the Hall angles and can change them by a factor of 2 as compared to the case of uncorrelated disorder. This might explain the vast range of anomalous Hall angles measured in experiments, which undergo different preparation procedures and thus might differ in their crystallographic quality.
OBJECTIVE: To assess the maxillary second molar (M2) and third molar (M3) inclination following orthodontic treatment of Class II subdivision malocclusion with unilateral maxillary first molar (M1) extraction.
MATERIALS AND METHODS: Panoramic radiographs of 21 Class II subdivision adolescents (eight boys, 13 girls; mean age, 12.8 years; standard deviation, 1.7 years) before treatment, after treatment with extraction of one maxillary first molar and Begg appliances and after at least 1.8 years in retention were retrospectively collected from a private practice. M2 and M3 inclination angles (M2/ITP, M2/IOP, M3/ITP, M3/IOP), constructed by intertuberosity (ITP) and interorbital planes (IOP), were calculated for the extracted and nonextracted segments. Random effects regression analysis was performed to evaluate the effect on the molar angulation of extraction, time, and gender after adjusting for baseline measurements.
RESULTS: Time and extraction status were significant predictors for M2 angulation. M2/ITP and M2/IOP decreased by 4.04 (95% confidence interval [CI]: -6.93, 1.16; P = .001) and 3.67 (95% CI: -6.76, -0.58; P = .020) in the extraction group compared to the nonextraction group after adjusting for time and gender. The adjusted analysis showed that extraction was the only predictor for M3 angulation that reached statistical significance. M3 mesial inclination increased by 7.38° (95% CI: -11.2, -3.54; P < .001) and 7.33° (95% CI: -11.48, -3.19; P = .001).
CONCLUSIONS: M2 and M3 uprighting significantly improved in the extraction side after orthodontic treatment with unilateral maxillary M1 extraction. There was a significant increase in mesial tipping of maxillary second molar crowns over time.
The upregulation of PGE2 by mesangial cells has been observed under chronic inflammation condition. In the present work, renal mesangial cells were stimulated to trigger a huge increase of PGE2 synthesis and were treated in the absence or presence of known PLA2 inhibitors. A variety of synthetic inhibitors, mainly developed in our labs, which are known to selectively inhibit each of GIVA cPLA2, GVIA iPLA2, and GIIA/GV sPLA2, were used as tools in this study. Synthetic sPLA2 inhibitors, such as GK115 (an amide derivative based on the non-natural amino acid (R)-γ-norleucine) as well as GK126 and GK241 (2-oxoamides based on the natural (S)-α-amino acid leucine and valine, respectively) presented an interesting effect on the suppression of PGE2 formation.
This region of western Greece has been frequently activated during the last decade, providing a large amount of enhanced quality new seismic information that was recorded by the Hellenic Unified Seismological Network (HUSN). In this work, the results of earthquake relocation, stress inversion and seismic traveltime tomography are presented, towards investigating the geodynamics of the study area. Inversion of ~2300 focal mechanisms indicates obliquity by 30 ̊ between shearing and the maximum horizontal stress along the major strike-slip faults, consistent with clockwise crustal rotation. Within the lower crust, the stress field appears to be constrained by larger scale deformation. Seismic velocity anomalies have been resolved by regional body-wave traveltime tomography, applying an iterative tomographic inversion scheme using phase data from more than 5000 seismic events. Preliminary 3D tomographic models indicate the presence of gross structures related with the western Hellenic Trench, the Cephalonia Transform Fault (CTF), the Aitoloakarnania shear zone, the Corinth Gulf and the Messinia graben. Dipping towards the east and segmentation of CTF between Cephalonia and Lefkas is evidenced by the resolved anomalies while a predominant NE-SW oriented low velocity zone observed in central Peloponnesus, related with dextral strike-slip faulting, marks a 90° rotation of the extensional stress direction that is found to occur at both sides.
The number of public health applications for molecular epidemiology and social network analysis has increased rapidly since the improvement in computational capacities and the development of new sequencing techniques. Currently, molecular epidemiology methods are used in a variety of settings: from infectious disease surveillance systems to the description of disease transmission pathways. The latter are of great epidemiological importance as they let us describe how a virus spreads in a community, make predictions for the further epidemic developments, and plan preventive interventions. Social network methods are used to understand how infections spread through communities and what the risk factors for this are, as well as in improved contact tracing and message-dissemination interventions. Research is needed on how to combine molecular and social network data as both include essential, but not fully sufficient information on infection transmission pathways. The main differences between the two data sources are that, firstly, social network data include uninfected individuals unlike the molecular data sampled only from infected network members. Thus, social network data include more detailed picture of a network and can improve inferences made from molecular data. Secondly, network data refer to the current state and interactions within the social network, while molecular data refer to the time points when transmissions happened, which might have happened years before the sampling date. As of today, there have been attempts to combine and compare the data obtained from the two sources. Even though there is no consensus on whether and how social and genetic data complement each other, this research might significantly improve our understanding of how viruses spread through communities.
As early as the seventeenth century, women have been going from one corner of the world to the other recording their experiences and reasons for publishing. Exploring, working and residing in regions of the East considered ‘safe for dynamic men only’ (Smith 1887), western women interacted with the peoples of Ottoman society, enjoying their warm and generous hospitality. Their gender allowed them to study, learn and become experts in areas where men had no access:the Ottoman households (harems), women's daily life, social gatherings and celebrations. Western and eastern women discuss harem slavery, marriage, adultery, childbirth, abortion, divorce, religion and women's rights. In reconsulting primary sources and focusing on the writings of nineteenth-century British women in Asia Minor (Turkey), this article contributes additional evidence on women's alternative representations or less degrading gaze, while revealing a patriarchal system's domestic-social reality that was founded on the institution of slavery. In other words, it differs from other studies in spotlighting the accounts that are illustrative of the polyethnic synthesis of the Ottoman households, i.e. the discourse on the multiethnic harem slavery institution, which distinguished Ottoman society, so as to provide a bigger picture and inspire new discussions.
As early as the seventeenth century, women have been going from one corner of the world to the other recording their experiences and reasons for publishing. Exploring, working and residing in regions of the East considered ‘safe for dynamic men only’ (Smith 1887, Through Cyprus, Author of ‘Glimpses of Greek life and Scenery, etc’. London: Hurst and Blacket), western women interacted with the peoples of Ottoman society, enjoying their warm and generous hospitality. Their gender allowed them to study, learn and become experts in areas where men had no access: the Ottoman harems, women's daily life, social gatherings and celebrations. Western and eastern women discuss harem slavery, marriage, adultery, childbirth, abortion, divorce, religion and women's rights. In reconsulting primary sources and focusing on the writings of nineteenth-century British women in Asia Minor (Turkey), this article contributes additional evidence on women's alternative representations or less degrading gaze, while revealing a patriarchal system's domestic-social reality that was founded on the institution of slavery. In other words, it differs from other studies in spotlighting the accounts that are illustrative of the polyethnic synthesis of the Ottoman households, i.e. the discourse on the multiethnic harem slavery institution, which distinguished Ottoman society, so as to provide a bigger picture and inspire new discussions.
We report on the effect of interfacial energy on the glass temperature, Tg, of several amorphous polymers with various glass temperatures and polymer/substrate interactions confined within self-ordered nanoporous alumina (AAO). The polymers studied include poly(phenylmethylsiloxane) (PMPS), poly(vinyl acetate) (PVAc), 1,4-polybutadiene (PB), oligostyrene (PS), and poly(dimethylsiloxane) (PDMS). The segmental dynamics and associated Tg’s are studied by means of dielectric spectroscopy. The interfacial energy for the polymer/substrate interface, γSL, is calculated with Young’s equation whereas the AAO membrane surface energy is obtained by measuring contact angles for several reference liquids. We find that interfacial energy plays a significant role in the segmental dynamics of polymers under confinement within AAO. There is a trend for a decreasing glass temperature relative to the bulk with increasing interfacial energy. PDMS exhibits the highest interfacial energy and the highest reduction in glass temperature within AAO. Other effects that may also contribute to changes in Tg are discussed.
RESUMEN:
Óscar Cerruto, en su novela Aluvión de fuego revela aspectos históricos y sociales de su país relacionados con la guerra de Chaco. Mediante un acercamiento histórico-cultural, se estudia el conflicto entre los representantes del poder y la población india y su impacto en la formación de la identidad boliviana.
PALABRAS CLAVE:
Indio, poder, mujer, historia, identidad.
ABSTRACT:
Óscar Cerruto, in his novel Aluvión de fuego, presents historical and social aspects of his country related to the Chaco’s war. Through a historical and cultural approach, we analyze the conflict between the representatives of the powerful upper class and the Indians, as well as its impact on the formation of the Bolivian identity.
KEYWORDS:
Indian, power, woman, history, identity.
PURPOSE: Stable fixation of distal humerus fracture fragments is necessary for adequate healing and maintenance of reduction. The purpose of this study was to measure the reliability and accuracy of interpretation of postoperative radiographs to predict which implants will loosen or break after operative treatment of bicolumnar distal humerus fractures. We also addressed agreement among surgeons regarding which fracture fixation will loosen or break and the influence of years in independent practice, location of practice, and so forth.
METHODS: A total of 232 orthopedic residents and surgeons from around the world evaluated 24 anteroposterior and lateral radiographs of distal humerus fractures on a Web-based platform to predict which implants would loosen or break. Agreement among observers was measured using the multi-rater kappa measure.
RESULTS: The sensitivity of prediction of failure of fixation of distal humerus fracture on radiographs was 63%, specificity was 53%, positive predictive value was 36%, the negative predictive value was 78%, and accuracy was 56%. There was fair interobserver agreement (κ = 0.27) regarding predictions of failure of fixation of distal humerus fracture on radiographs. Interobserver variability did not change when assessed for the various subgroups.
CONCLUSIONS: When experienced and skilled surgeons perform fixation of type C distal humerus fracture, the immediate postoperative radiograph is not predictive of fixation failure. Reoperation based on the probability of failure might not be advisable.
TYPE OF STUDY/LEVEL OF EVIDENCE: Diagnostic III.
Eukaryotic cells heavily depend on adenosine triphosphate (ATP) generated by oxidative phosphorylation (OXPHOS) within mitochondria. ATP is the major energy currency molecule, which fuels cell to carry out numerous processes, including growth, differentiation, transportation and cell death among others (Khakh and Burnstock, 2009). Therefore, ATP levels can serve as a metabolic gauge for cellular homeostasis and survival (Artal-Sanz and Tavernarakis, 2009; Gomes et al., 2011; Palikaras et al., 2015). In this protocol, we describe a method for the determination of intracellular ATP levels using a bioluminescence approach in the nematode Caenorhabditis elegans.
Conduction of electrical signals along the surface of muscle fibers is acknowledged as an essential neuromuscular component which is linked with muscle force production. However, it remains unclear whether muscle fiber conduction velocity (MFCV) is also linked with explosive performance. The aim of the present study was to investigate the relationship between vastus lateralis MFCV and countermovement jumping performance, the rate of force development and maximum isometric force. Fifteen moderately-trained young females performed countermovement jumps as well as an isometric leg press test in order to determine the rate of force development and maximum isometric force. Vastus lateralis MFCV was measured with intramuscular microelectrodes at rest on a different occasion. Maximum MFCV was significantly correlated with maximum isometric force (r = 0.66, p < 0.01), nevertheless even closer with the leg press rate of force development at 100 ms, 150 ms, 200 ms, and 250 ms (r = 0.85, r = 0.89, r = 0.91, r = 0.92, respectively, p < 0.01). Similarly, mean MFCV and type II MFCV were better correlated with the rate of force development than with maximum isometric leg press force. Lower, but significant correlations were found between mean MFCV and countermovement jump power (r = 0.65, p < 0.01). These data suggest that muscle fiber conduction velocity is better linked with the rate of force development than with isometric force, perhaps because conduction velocity is higher in the larger and fastest muscle fibers which are recognized to contribute to explosive actions.
The Magellanic Clouds harbour a large sample of Be/X-ray binariesat a moderate and well known distance with low Galactic foregroundabsorption. However, the transient nature of Be/X-ray binaries complicatesobservations in X-rays. Serendipitous detections of bright outburstsprovide rare chances for further investigation. We propose three triggeredXMM-Newton observations of new or unexplored systems to continue thebuild up of a large statistical sample of these sources.
Evolution Teaching (ET) among In-Service teachers in Greece was examined in an attempt to evaluate their Pedagogical Content Knowledge. Evolution teaching is a problematic issue. For this purpose, we constructed a questionnaire that was distributed to the target population and to which 181 teachers responded. We used quantitative method to determine factors that may characterize the ET milieu and which of the factors of PCK apply or not to ET. Our research finds that Biology teachers although strive to teach evolution, face specific difficulties due to lack of PCK. The research results may be useful when organizing and implementing professional development programs of teachers on ET.
Fires of 2007 have consumed large areas of Black pine and Greek fir forests in Peloponnese, Euboea and Attica. Most studies that followed, focused on the natural regeneration potential or the need for reforestation. The current research aims at examining the role of geomorphology and lithology that govern the soil properties upon the post-fire vegetation recovery at the landscape level. A case study from Taygetos Mt, a large part of which was burned in 2007, is presented. Based on the interpretation of a high spatial and spectral resolution satellite image (WorldView-3, 4/2015), several GIS thematic layers have been created showing unburned and regenerated patches over various lithological types. A network of sites was selected for field sampling representing various combinations of the above. Data on vegetation cover and recovery of the main tree species were collected. Results prove the interrelationship between regeneration and species traits as well as the existence of unburned patches near the burned ones. Recovery seems to be controlled by the geology of the plots as it was found weaker in plots overlying carbonate, permeable, not easily erodible formations as compared to that observed over clastic, impermeable, erodible formations of schists, even for the same species. In conclusion, post-fire vegetation recovery at the landscape level seems to be a complex process controlled not only from species biology but also from the landscape features and its fire history.
This paper investigates the contagion effects of the global financial crisis (GFC) and Eurozone sovereign debt crisis (ESDC) on Islamic equity and bond markets. Using a sample of Islamic stock indices from various developed and emerging markets and the global Islamic stock and bond (sukuk) indices, we explore asymmetric conditional correlation dynamics across stable and crisis periods and across the two crises. The results fail to provide strong contagion evidence between conventional and Islamic equity and bond indices, supporting the decoupling hypothesis of the Islamic securities. Our findings imply that Islamic equities and bonds may provide a cushion against risk and instability, particularly in periods of turmoil. The small number of contagion cases mostly relates to the ESDC and developed Islamic stock indices. The findings also show that the Islamic emerging stock indices in the BRICS provide the most effective international portfolio diversification benefits compared to the Islamic developed indices.
INTRODUCTION: Tissue kallikrein and the kallikrein-related peptidases (KLKs) constitute a family of 15 homologous secreted serine proteases with trypsin- or chymotrypsin-like activities, which participate in a broad spectrum of physiological procedures. Deregulated expression and/or activation of the majority of the family members have been reported in several human diseases, thereby making KLKs ideal targets for therapeutic intervention. AREAS COVERED: In the present review, we summarize the role of KLKs in normal human physiology and pathology, focusing on prostate cancer and skin diseases. Furthermore, we discuss the recent advances in the development of KLK-based therapies. A great number of diverse engineered KLKs inhibitors with improved potency, selectivity and immunogenicity have been synthesized by redesigning examples that are endogenous and naturally occurring. Moreover, encouraging results have been documented using KLKs-based vaccines and immunotherapies, as well as KLKs-mediated activation of pro-drugs. Finally, KLKs-targeting aptamers and KLKs-based imaging tools represent novel approaches towards the exploitation of KLKs' therapeutic value. EXPERT OPINION: The central/critical roles of KLK family in several human pathologies highlight KLKs as attractive molecular targets for developing novel therapeutics.
El objeto del presente trabajo es examinar si el nivel lingüístico en lengua extranjera afecta la disponibilidad léxica de aprendientes griegos de español. Para ello, se han analizado diferentes aspectos cuantitativos y cualitativos de la disponibilidad léxica de dos grupos de aprendientes griegos que tienen un nivel lingüístico diferente (B1 y C1) en español siguiendo las pautas metodológicas en las que se basan los estudios de disponibilidad léxica. Se ha recogido léxico de tres campos semánticos (comida y bebida, la casa, profesiones y oficios) y los datos se han analizado con el objetivo de encontrar el número de palabras producidas, el promedio de las palabras producidas por participante, el número de vocablos (palabras diferentes), el promedio de los vocablos producidos por participante, el índice de cohesión y las palabras más comunes de cada campo semántico. Los resultados del estudio han indicado que el nivel lingüístico en lengua extranjera afecta la disponibilidad léxica de los dos grupos de aprendientes griegos de español en todos los campos semánticos analizados. La explicación se basa en el desarrollo y la organización del lexicón mental en lengua extranjera.
El tema que examina el presente artículo es la necesidad de enseñanza de las estrategias compensatorias en la clase delenguas extranjeras. Se trata de un tema polémico, que ha suscitado un debate entre los investigadores. En un intento de daruna visión global del tema, se presentan algunos de los argumentos de las dos posturas opuestas y se mencionan algunasconsideraciones que se deben tener en cuenta antes de decidir si su enseñanza se debería incluir en el currículo deaprendizaje de lenguas extranjeras.
Les difficultés de compréhension et d'appropriation qu'éprouvent les étudiants, face à un domaine cognitif parfois trop théorique, sont à l'origine de cette étude de cas. Notre but est d'explorer le rôle que peut jouer la traduction dans l'appréhension et l'approfondissement des contenus d'un cours disciplinaire de cursus universitaire de premier cycle. Pour ce faire, nous décrirons la réalisation d'un travail de traduction collaborative présentée sous forme de situation-problème selon les principes de l'apprentissage par problèmes
Papapanagiotou IK, Kalles V, Migklis K, Sgantzos M, Kaklamanos I, Mariolis-Sapsakos T. Langer's axillary arch. Clin Case Rep. 2016;4(6):613.Abstract
Langer's axillary arch is usually asymptomatic and difficult to detect preoperatively. When present, it is important for surgeons operating in the axillary region, to identify correctly the relevant anatomy. Simple surgical division is curative and necessary in order to achieve exposure of the axillary contents, lymphatic dissection, and neurovascular preservation.
Fossil shorelines produced by recent co-seismic movements were identified through a submarine survey along the coasts of Ithaca and Fiscardo (Greece). In both areas a tidal notch-slightly submerged below present Mean Sea Level (MSL) was observed at various sites. This “modern” notch is known to have been submerged by the global sea-level rise during the 19th and 20th centuries. The depth after tide and air-pressure correction of the vertex of the “modern” notch (that owes its submergence to the current rapid sea level rise) was measured between -20 and -30±5cm at Fiscardo and between -36 and -45±6cm at Ithaca. This “modern” notch at the same depth on east and west sides of the Ionian Thrust suggests that both areas were not affected by the co-seismic vertical movements that occurred in 1953 (in the wider area). On the other hand, a greater depth in Ithaca could be an effect of co-seismic subsidence. Over the long term, the tectonic behavior of Ithaca differs from Fiscardo. At Ithaca no evidence of emergence was found and Holocene vertical movements have been only of subsidence: submerged fossil tidal notches were distinguished below MSL at about -40 (modern), -60, -75, -95, -106, -126, -150 and -220±6cm. On the East coast of Fiscardo peninsula impacts of ancient earthquakes have left some marks of emergence at about +18 and +44±5cm, and of submergence at about -25 (modern), -45, -60, -75, -82, -100 and -230cm, with even some evidence of past uplift and subsidence at the same sites.
Benthic foraminiferal composition assemblages and their temporal changes, ecological indices and foraminiferal densities are used to compare three coastal environments with different physicogeographical features in the Aegean Sea (coastal environment of Avdira–Vistonikos Gulf and Kitros–Thermaikos Gulf and open lagoonal environment of Vravron–South Evoikos Gulf). Three main foraminiferal assemblages have been recognized: a) “Assemblage A”; high degree of similarity between living and dead foraminiferal species, dominated byAmmonia beccarii, Elphidium spp. and relatively abundant and diverse miliolids, b) “Assemblage B1”; intermediate degree of similarity between live and dead assemblages, characterized by highly-abundant and well-diversified foraminiferal assemblages including the algal symbiont bearing Peneroplis pertusus together withAmmonia tepida and several small epiphytic rotaliids and miliolids, and c) “Assemblage B2”; absence of living individuals, strongly dominated by the opportunistic species A. tepida. Our results suggest a good comparison between living and dead assemblages from different coastal environments in the Aegean Sea, however the prevailing environmental conditions (vegetation cover, hydrodynamics, fresh water influx) have a strong impact on the taphonomic processes.
We calculate the lowest ionisation and excitation energies in a variety of biologically important molecules, i.e. π-conjugated systems like DNA and RNA bases and isomers plus related heterocyclic molecules. For approximately half of these molecules, there are no experimental and theoretical/numerical data in the literature, as far as we know. These electronic transitions are mainly but not exclusively of π and π–π* character, respectively. We perform symmetry-constrained density functional theory (DFT) geometry optimisation at the B3LYP/6-311++G** level of theory. At the DFT-obtained ground-state geometries, we calculate vertical ionisation energies with ionisation potential coupled cluster with singles and doubles (IP-EOMCCSD) and vertical excitation energies with the completely renormalised equation of motion coupled cluster with singles, doubles, and non-iterative triples (CR-EOMCCSD(T)) method. We also investigate whether a simple semi-empirical Hückel-type model approach with novel parametrisation could provide reasonable estimates of the lowest π ionisation and π–π* excitation energies. Our coupled cluster (CC) results are in very good agreement with experimental data, while the Hückel-type model predictions generally follow the trends with some deviation. Finally, we investigate the effect of basis set in IP-EOMCCSD energies and we compare our CR-EOMCCSD(T) results with time-dependent DFT (TDDFT) ones.
Potari D, Psycharis G, Spiliotopoulou V, Triantafillou C, Zachariades T, Zoupa A. Mathematics and science teachers' collaboration: searching for common grounds. In: Csikos C, Rausch A, Szitanyi J Proceedings of the 40th Conference of the International Group for the Psychology of Mathematics Education (PME 40). Vol. 4. Szeged, Hungary: PME; 2016. pp. 91-98.pme_40_2016b.pdf
Ependymal cells are multiciliated cells located in the wall of the lateral ventricles of the adult mammalian brain and are key components of the subependymal zone niche, where adult neural stem cells reside. Through the movement of their motile cilia, ependymal cells control the cerebrospinal fluid flow within the ventricular system from which they receive secreted molecules and morphogens controlling self-renewal and differentiation decisions of adult neural stem cells. Multiciliated ependymal cells become fully differentiated at postnatal stages however they are specified during mid to late embryogenesis from a population of radial glial cells. Here we discuss recent findings suggesting that 2 novel molecules, Mcidas and GemC1/Lynkeas are key players on radial glial specification to ependymal cells. Both proteins were initially described as cell cycle regulators revealing sequence similarity to Geminin. They are expressed in radial glial cells committed to the ependymal cell lineage during embryogenesis, while overexpression and knock down experiments showed that are sufficient and necessary for ependymal cell generation. We propose that Mcidas and GemC1/Lynkeas are key components of the molecular cascade that promotes radial glial cells fate commitment toward multiciliated ependymal cell lineage operating upstream of c-Myb and FoxJ1.
The rate of oxygen consumption is a vital marker indicating cellular function during lifetime under normal or metabolically challenged conditions. It is used broadly to study mitochondrial function (Artal-Sanz and Tavernarakis, 2009; Palikaras et al., 2015; Ryu et al., 2016) or investigate factors mediating the switch from oxidative phosphorylation to aerobic glycolysis (Chen et al., 2015; Vander Heiden et al., 2009). In this protocol, we describe a method for the determination of oxygen consumption rates in the nematode Caenorhabditis elegans.
We developed an extension of the layer-multiple-scattering method to photonic crystals comprising homogeneous layers of magneto-optical materials. The applicability of the method is demonstrated on a specific architecture of a magnetic garnet thin film coated with a square array of silver nanodisks, supported by a silica substrate. It is shown that enhanced Faraday rotation, driven by hybrid particle plasmon-film quasi-guided collective modes, can be achieved within selected regions of frequency, which can be tuned by properly choosing the geometric and material parameters involved. The results are analyzed in conjunction with numerical simulations by the finite-element method and a consistent interpretation of the underlying physics is provided. Our extended layer-multiple-scattering computational methodology provides a versatile framework for fast and accurate full electrodynamic calculations of magneto-optical structures, enabling physical insight.
Mitophagy is a conserved, mitochondria-specific autophagic clearance process. We recently discovered an intricate regulatory network that balances mitophagy with mitochondrial biogenesis. Proper coordination of these opposing processes is important for stress resistance and longevity. Nodal regulatory factors that contribute to mitochondrial homeostasis have also been linked to carcinogenesis, highlighting mitophagy as a potential target for therapeutic interventions against cancer.
Macheras P, Iliadis A. Modeling and Simulation in Bioequivalence. In: MODELING IN BIOPHARMACEUTICS, PHARMACOKINETICS AND PHARMACODYNAMICS: HOMOGENEOUS AND HETEROGENEOUS APPROACHES, 2ND EDITION. Vol. 30. 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES: SPRINGER; 2016. pp. 227-254.
Modeling in Biopharmaceutics. In: MODELING IN BIOPHARMACEUTICS, PHARMACOKINETICS AND PHARMACODYNAMICS: HOMOGENEOUS AND HETEROGENEOUS APPROACHES, 2ND EDITION. Vol. 30. 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES: SPRINGER; 2016. pp. 51-52.
Modeling in Pharmacodynamics. In: MODELING IN BIOPHARMACEUTICS, PHARMACOKINETICS AND PHARMACODYNAMICS: HOMOGENEOUS AND HETEROGENEOUS APPROACHES, 2ND EDITION. Vol. 30. 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES: SPRINGER; 2016. pp. 341-342.
Modeling in Pharmacokinetics. In: MODELING IN BIOPHARMACEUTICS, PHARMACOKINETICS AND PHARMACODYNAMICS: HOMOGENEOUS AND HETEROGENEOUS APPROACHES, 2ND EDITION. Vol. 30. 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES: SPRINGER; 2016. pp. 159-160.
Within this study we introducea framework for assessing spatial fire risk and exposure to three important habitat types in Cephalonia island, Greece.Existing maps were used for plot allocation in orderto measure several fuel parameters in representative natural fuel complexes for site-specific fuel models development, as well as for collecting training and validation points for satellite data classification. The spatial extent of the fuel types and the canopy cover were delineated using a Landsat 8 OLI image acquired on 23-7-2015and the Support Vector Machines-(SVMs) machine learning algorithm. Subsequently, The Minimum Travel Time (MTT) algorithm, as it is embedded in FlamMap spatial fire simulation software, was applied in order to assess critical fire behavior parameters and exposure of Cephalonia's habitats under three different meteorological and fuel moisture scenarios. The outputs of this study may be used as an application of quantitative and probabilistic risk assessment for habitats conservation planning, prioritization and management of high value natural and cultural resources.
Sgr A* is an ideal target to study low-luminosity accreting systems. It has been recently proposed that properties of the accretion flow around Sgr A* can be probed through its interactions with the stellar wind of nearby massive stars belonging to the S-cluster. When a star intercepts the accretion disc, the ram and thermal pressures of the disc terminate the stellar wind leading to the formation of a bow shock structure. Here, a semi-analytical model is constructed which describes the geometry of the termination shock formed in the wind. With the employment of numerical hydrodynamic simulations, this model is both verified and extended to a region prone to Kelvin-Helmholtz instabilities. Because the characteristic wind and stellar velocities are in ∼108 cm s-1 range, the shocked wind may produce detectable X-rays via thermal bremsstrahlung emission. The application of this model to the pericentre passage of S2, the brightest member of the S-cluster, shows that the shocked wind produces roughly a month long X-ray flare with a peak luminosity of L ≈ 4 × 1033 erg s-1 for a stellar mass-loss rate, disc number density, and thermal pressure strength of dot{M}_w= 10^{-7} M_{⊙} yr^{-1}, nd = 105 cm-3, and α = 0.1, respectively. This peak luminosity is comparable to the quiescent X-ray emission detected from Sgr A* and is within the detection capabilities of current X-ray observatories. Its detection could constrain the density and thickness of the disc at a distance of ∼3000 gravitational radii from the supermassive black hole.
