Publications

We report measurements of single-electron polarization in a coupled double-quantum-dot device isolated from current probes and demonstrate that the energetics observed for this process differs from that observed in double dots coupled to reservoirs. The movement of the electrons is detected by a quantum point contact. By analyzing the energy broadening corresponding to the tunneling of a single electron from one dot to the other we estimate a minimum for the intradot scattering time to be 0.2 ns. This energy broadening follows the predicted shot-noise variation in the detector with gate voltage, but is three orders-of-magnitude higher. We speculate that two-level systems could account for the discrepancy.

Background: The purpose of this study was to evaluate the role of dynamic contrast-enhanced magnetic resonance imaging (dMRI) in detecting bone marrow involvement in cancer patients. Patients and methods: We studied 50 consecutive patients with histologically confirmed malignant dissemination to the bone marrow, using dMRI of the lumbosacral spine. Time-signal intensity curves were generated from regions of interest (ROIs) obtained from areas of obvious bone marrow disease (group B). In 16 patients from group B with focal disease, ROIs were also placed on areas with apparently normal bone marrow on static magnetic resonance images (group C). Twenty-two patients with no history of malignancy were used as a control group (group A). Wash-in (WIN) and wash-out (WOUT) rates, time to peak (TTPK), time to maximum slope (TMSP) values and WIN/TMSP ratios were calculated for each patient. Mean values for the three groups were compared statistically. Six patients from group B had follow-up dMRI after chemotherapy: four patients achieved a clinical partial response and two had resistant disease. Results: A significant difference was found between groups A and B for all values. Between groups A and C, in spite of the similar static MRI appearance, all values were significantly different. Between groups B and C, a significant difference was found for WIN, WOUT rates and WIN/TMSP ratio. Follow-up dMRI data analysis correlated well with clinical staging. Conclusions: dMRI can distinguish normal from malignant bone marrow. It may identify malignant bone marrow infiltration in patients with negative static MRI and serve as both a diagnostic and prognostic tool for patients with bone marrow malignancies.

The aim of this study was to evaluate factors that influence leptin levels in postmenopausal women. One hundred and forty-four postmenopausal women were evaluated cross-sectionally. In every woman a complete medical history was obtained, body mass index (BMI) was recorded and morning fasting blood was obtained for the determination of serum leptin, follicle stimulating hormone (FSH), estradiol, testosterone, Δ4androstendione, clehydroepiandrosterone sulphate (DHEAS) and insulin. In univariate analysis, age, BMI and insulin were positively correlated with serum leptin, while DHEAS showed a negative association with leptin concentrations (age r=0.21, p=0.005, BMI r=0.41, p=0.0001, insulin r=0.20, p=0.008, DHEAS r=-0.28, p=0.0001). In stepwise multivariate regression analysis serum leptin could be best predicted from BMI, serum insulin and serum DHEAS [leptin= (1.41 * BMI) - (0.01 * DHEAS) + (3.26 * insulin) -26.3; model r2=0.24, p=0.001]. In conclusion, BMI and serum insulin have a positive while serum DHEAS has a negative impact on serum leptin. Neither endogenous estradiol, nor endogenous testosterone are associated with leptin levels. Further studies are needed to elucidate the role of leptin in determining body weight and composition in postmenopausal women. © 2003, Editrice Kurtis.

The (diphenylphosphino)alkyl-functionalized nucleophilic heterocyclic carbene (NHC) complexes of palladium LPdX2 (L = (3-R1)[1-Ph2P(CH2)2]-imidazol-2-ylid ene; R1 = 2,6-Pr2iC6H3, 2,4,6-Me3C6H2; X = CH3 (3a,b), X = Br (4a,b)) have been synthesized by the reaction of the in situ generated functionalized NHC ligand La or Lb with Pd(tmed)(CH3)2 and Pd(COD)Br2, respectively, and structurally characterized. Interaction of 3a with H(Et2O)- {B[3,5-(CF3)2C6H2]4} and pyridine or with (CF3)2CHOH and pyridine in CH2Cl2 gave the monocationic complexes [(La)Pd(CH3)(pyridine)]+(A)- (A- = {B[(3,5-CF3)2C6H2]4}-, (CF3)2CHO-); acetonitrile and benzonitrile analogues can be prepared in an analogous way. Reaction of 4a with AgBF4 in MeCN gave the dicationic complexes [(La)Pd(MeCN)2](BF4)2. Complexes 3 show moderate catalytic activity for the coupling of acrylates with aryl bromides but not chlorides. The cationic species generated in situ from 3a and H(Et2O){B[(3,5-CF3) 2C6H2]4} in CH2Cl2 under CO/ethylene acts as a copolymerization catalyst under mild conditions.

We study the dispersion characteristics of a rectangular waveguide grating for microwave amplifier applications. The Floquet theorem and an appropriate standing waves expansion is employed to express the fields in the vacuum region and inside the grooves, respectively. The application of the boundary conditions leads to an infinite system of equations, which is solved numerically by truncation. The main advantage of the procedure employed is that it gives directly and with a few spatial harmonics the dispersion relation. Furthermore, an adequate procedure (simulation tool) has been introduced in order to distinguish the real roots from spurious solutions and it has been found to work effectively for all cases presented in this work. Numerical results are presented for both shallow and deep grooves and comparison with previously published works is made.

There is some evidence that taxanes and gemcitabine are effective antitumor agents against small-cell lung cancer (SCLC). A total of 20 chemotherapy-naive patients with extensive disease (ED) SCLC, were treated as a part of the first step of a phase II study, with docetaxel 50 mg/m2 and gemcitabine 1000 mg/m2, both administered on day 1 and 8 every 3 weeks up to a total of six cycles. For patients who progressed after the first cycle or had stable disease after the second cycle of chemotherapy, protocol treatment was stopped and further treatment with the standard cisplatin or carboplatin-etoposide combination was administered. Patients were in the vast majority male smokers with a good performance status. A total of 72 cycles was delivered while patients managed to receive the 78 and 84% of the planned dose of docetaxel and gemcitabine, respectively. Only six patients responded partially and the trial ended prematurely since at least seven responses were required among the first 19 patients. With a median follow-up of 13 months, median time to progression (TTP) was 8 months and median survival 9.6 months. Hematological and non-hematological toxicity was generally acceptable while patients tolerated their treatment reasonably well. In conclusion, docetaxel-gemcitabine showed a modest response rate in chemotherapy-naive patients with ED SCLC. © 2003 Elsevier Science Ireland Ltd. All rights reserved.

This paper presents the design and implementation of an internet based nursing care planning system which helps nursing professionals and students to study ICNP beta 2 version and to create nursing diagnoses, interventions and outcomes by selecting relevant terms from ICNP. This advanced web-based ICNP browser enables the authentication of the user, and the creation of a type of nursing care plan through the use of ICNP. It provides different ways for creating nursing diagnoses, interventions and outcomes, by selecting relevant ICNP terms through the tree-structure view, index and search components of the tool. The created diagnoses, interventions and outcomes are stored to a secured database. The system provides to the user the facility to build and manage nursing care plans by using both the English and the translated Greek ICNP versions. The first results of the implementation of this internet based nursing care planning system are presented.

In this paper we examine methods of digital image processing, in order to extract drainage system branches and import them into a GIS layer. Moreover, we have developed special algorithms on GIS environment in order to analyse drainage system parameters. In order to get the optimum detection of the drainage system characteristics, we applied on the Landsat image and on aerial photos several filters. Using the aerial photos of the area, we created the orthophotomosaic, which came out of the ortho-rectified aerial photos. Via stereoscopic observation on the computer screen, we detected and digitized the drainage system branches. Using special algorithms, developed under the MapBasic programming language, we evaluated the drainage system and the faults directions, in order to analyse them quantitatively and geographically.

Using relativistic, axisymmetric, ideal MHD, we examine the outflow from a debris disk around a newly formed stellar-mass black hole, taking into account the baryonic matter, the electron-positron/photon fluid, and the large-scale electromagnetic field. We clarify the relationship between the thermal (fireball) and magnetic (Poynting flux) acceleration mechanisms, identify the parameter regimes where qualitatively different behaviors are expected, and demonstrate that the observationally inferred properties of the GRB outflows can be attributed to magnetic driving. We show that the Lorentz force can convert up to 50% of the initial total energy into kinetic energy of a collimated flow of baryons. This energy, in turn, may be converted into radiation by internal shocks. We examine how baryon loading and magnetic collimation affect the structure of the flow.

Using relativistic, axisymmetric, ideal MHD, we examine the outflow from a debris disk around a newly formed stellar-mass black hole, taking into account the baryonic matter, the electron-positron/photon fluid, and the large-scale electromagnetic field. We clarify the relationship between the thermal (fireball) and magnetic (Poynting flux) acceleration mechanisms, identify the parameter regimes where qualitatively different behaviors are expected, and demonstrate that the observationally inferred properties of the GRB outflows can be attributed to magnetic driving. We show that the Lorentz force can convert up to 50% of the initial total energy into kinetic energy of a collimated flow of baryons. This energy, in turn, may be converted into radiation by internal shocks. We examine how baryon loading and magnetic collimation affect the structure of the flow.

Greenhouse experiments were carried out to evaluate the effect of different soil-based countermeasures on radiocesium transfer to Medicago sativa (alfalfa) grown on artificially contaminated loamy-clayey soil. Various rates of potassium, ammonium, and Prussian Blue supplements were applied, and the uptake of radiocesium by control and treated alfalfa plants was monitored during four growth periods. Transfer factors ranging between 0.06 and 0.02 were determined for control plants. Application of potassium at rates higher than 0.1 meq per 100 g soil was found to suppress radiocesium uptake, the effect being more pronounced at increasing fertilization rates. On the contrary, soil treatment with ammonium enhanced the bio-accumulation of radiocesium, indicating that Cs+ ions, previously unavailable to plant roots, were released from soil particles. Prussian Blue supplements had practically no effect on soil-to-alfalfa transfer of the radionuclide.

PURPOSE: Raloxifene is a selective estrogen receptor modulator and an attractive alternative to estrogen replacement as it obviates the need for a progestin and does not increase C-reactive protein levels. We compared the effects of simvastatin and raloxifene treatments on the lipid profile, the levels of adhesion molecules and the endothelium dependent and independent vasoreactivity. SUBJECTS & METHODS: We treated 12 postmenopausal women with hypercholesterolemia and coronary artery disease with raloxifene 60 mg/day and simvastatin 20 mg/day in a randomized, double-blind, crossover study. Each treatment period was 8 weeks long with a 4-week washout interval. Plasma lipids and cellular adhesion molecules were evaluated and peripheral blood flow studies with venous occlusion plethysmography were performed. RESULTS: Both simvastatin and raloxifene significantly reduced total [33% (27-40), 12% (0-24)] and LDL [44% (36-52), 16% (0-33)] cholesterol compared to baseline values (p < 0.05) but simvastatin was more effective than raloxifene (p < 0.005). None of the treatments had any significant effect on HDL cholesterol and triglyceride levels. Only raloxifene significantly reduced Lp(a) [18% (1-36)] and ICAM-1 [17% (8-25)] and VCAM-1 [24% (15-33)] plasma levels compared to baseline (p = 0.019, p < 0.0001 and p = 0.003, respectively). Hyperemic blood flow response on raloxifene was significantly higher compared to baseline [52% (0-105)], (p < 0.05), whereas no significant change was noted on simvastatin. Endothelium independent blood flow induced by nitroglycerine was not influenced by either active treatment. CONCLUSIONS: Raloxifene administration is associated with lower ICAM-1, VCAM-1 and Lp(a) plasma levels and enhanced endothelium dependent dilation compared to simvastatin although simvastatin is more powerful in total and LDL cholesterol reduction

A methodology to estimate annual transboundary atmospheric transport is proposed, taking into account different background meteorological conditions. For this purpose, the 850 hPa synoptic-scale atmospheric circulation over the area examined was classified on a daily basis into 14 distinct synoptic types, using a database for an extended period of 40 years. The corresponding frequency of appearance of the synoptic types for a normal year was calculated. For selected days representing the synoptic types during this year, the inflow-outflow fluxes of NOx and SO2 were estimated through a balancing box with the aid of a MEMO/TRAPPA modelling system. According to the proposed method, the total inflow-outflow fluxes were calculated using the lateral fluxes for each representative day, being weighted by the annual relative frequency of appearance of the synoptic scale weather types. It was demonstrated that this approach provides similar results to the intensive method based on day-by-day calculations. Furthermore, this approach is easier to use, since it is based on the simulations of selected days, and it allows the investigation of the influence of different types of atmospheric circulation on the inflow-outflow budget. Copyright © 2003 Royal Meteorological Society.

The European Communities Confederation of Clinical Chemistry and Laboratory Medicine (EC4) opened a Register for European Chemists in 1997. The operation of the Register is undertaken by a Register Committee (EC4RC). During the last 5 years more than 1400 clinical chemists entered the register. In this article an update of the first Guide to the Register is given, based on the experience of 5 years of operation and the development of the discipline. The registration is valid for 5 year. In a second part the procedure and the conditions for re-registration are presented.

We present evidence for quantum dot cellular automata action in a cell consisting of four dots defined by submicron metal gates on the top surface of a molecular-beam-epitaxy-grown GaAs/AlGaAs heterostructure in which a two-dimensional electron gas layer was formed approximately 70 nm below the surface. The four-dot cell is separated by a strong barrier in two double-dot sets. We show that by polarizing one of the double-dot sets we can polarize the other set in the cell. The polarization is detected using noninvasive voltage probe without drawing electric currents from the cell.

Recent highlights of our study of positive and negative superhumps in cataclysmic varibles are briefly reviewed. The ``genuine" superhumps have been detected a day after the unexpected superoutburst of WZ Sge, when the orbital variability dominated the light curve. TT Ari has shown an unprecedented switch form the usual negative superhump state to the positive state with an excellent coincidence between the observed and theoretically predicted period values. Both stars show evidence for variability at a time scale of 20 minutes. The superhump period of RZ LMi has been corrected based on the observations of the superoutburst in 2001. ES Dra shows no evidence for prominent superhumps, possibly indicationg its low inclination. However, the superoutburst has shown a splitted maximum with a separation of 20 days. The ``superhump period-luminosity" dependence has been detected for two cataclysmic variables of different types -- the nova-like BZ Cam and the UG SU star V368 Peg.

An expanded cytotoxic/memory T-cell subpopulation expressing low levels of the B-cell-specific CD20 molecule was found in peripheral blood and bone marrow of patients with multiple myeloma at the time of diagnosis, but returned to normal levels following treatment. CD3+CD20dim cells were also increased in monoclonal gammopathy of unknown significance albeit at lower levels. Lower CD3+CD20dim cell numbers at baseline may be associated with lack of response to treatment and a poor outcome. Because expansion of these T cells may be related to disease status, further studies should investigate their potentially unique function in plasma cell dyscrasias.

The nemaline myopathies (NMs) are a clinically and genetically heterogeneous group of disorders characterized by nemaline rods and skeletal muscle weakness. Mutations in five sarcomeric thin filament genes have been identified. However, the molecular consequences of these mutations are unknown. Using Affymetrix oligonucleotide microarrays, we have analyzed the expression patterns of >21,000 genes and expressed sequence tags in skeletal muscles of 12 NM patients and 21 controls. Multiple complementary approaches were used for data analysis, including geometric fold analysis, two-tailed unequal variance t test, hierarchical clustering, relevance network, and nearest-neighbor analysis. We report the identification of high satellite cell populations in NM and the significant down-regulation of transcripts for key enzymes of glucose and glycogen metabolism as well as a possible regulator of fatty acid metabolism, UCP3. Interestingly, transcript level changes of multiple genes suggest possible changes in Ca(2+) homeostasis. The increased expression of multiple structural proteins was consistent with increased fibrosis. This comprehensive study of downstream molecular consequences of NM gene mutations provides insights in the cellular events leading to the NM phenotype.

The paper addresses the commonly acknowledged challenge of globalisation with respect to the area of English language teaching and, more particularly, teaching English to speakers of foreign languages. It is argued that some of the primary issues involved concern the increasing role of technology and communication in modern societies and the looming conflict between local communities and the decision-making bodies. It is further suggested that the global English language teaching (ELT) community has already gone a long way towards researching and, in certain cases, resolving such conflicts and has much insightful material to offer. The paper incorporates a discussion of the notion of English as an international language and the question of 'ownership' of such a language. The roles and defining characteristics of the native and non-native speaker of English are then considered and the various occasions when communication and learning take place are briefly reviewed, with frequent reference to the authors' own teaching situation, i.e. English language teaching in Greece. The paper culminates with an appreciation of the pedagogical, ethical and methodological considerations that are suggested as a means of sensitising TESOL teacher education vis à vis the global status of English (also with the Greek context in mind).

The geomorphology of Greece is the result of multiphase tectonic movements of compressional and extensional nature plus exogenous processes. In this complex relief a Mediterranean-type ecosystem has been developed reflecting the prevailing climatic conditions. The frequent occurrence, especially during summer, of strong winds and high temperatures are the main reasons for extensive fires. The aim of this paper is to develop a methodology to face with this increasing danger using fuzzy set theory in a Web-GIS platform. As a case study of this work the two of the Ionian islands, Zakynthos and Kefallinia have been chosen, which are characterized by a relatively well developed vegetative cover and frequently recurring fires. It is widely accepted that the fire management is of primary importance for the environmental protection and planning.

Contrary to the two other major Augustan writers who discussed the origins of Rome, Vergil's Roman prehistory centers on the presence of Evander. An involuntary exile from the East (Greek Arcadia) who settled in Latium and instilled civilization and laws among the Italians, Evander is a duplicate of Aeneas, a cultural ancestor and a model of leadership. Aeneas is instructed by the deities of Italy (Tiberinus) to pay a visit to Pallanteum, Evander's capital and the primordial site of Rome, in order to learn about the past and receive instructions about the future. His tour of proto-Rome, led by Evander, carries Aeneas through a series of monuments that span through Rome's entire history. Aeneas is guided to follow Evander's example, and Vergil, urging reevaluation of widespread anti-Hellenic prejudices, prominently underscores the seminal contribution of Greece to the cultural and political origins of Rome.

We have re-examined the random release of particles from fractal polymer matrices using Monte Carlo simulations, a problem originally studied by Bunde {[}J. Chem. Phys. 83, 5909 (1985)]. A certain population of particles diffuses on a fractal structure, and as particles reach the boundaries of the structure they are removed from the system. We find that the number of particles that escape from the matrix as a function of time can be approximated by a Weibull (stretched exponential) function, similar to the case of release from Euclidean matrices. The earlier result that fractal release rates are described by power laws is correct only at the initial stage of the release, but it has to be modified if one is to describe in one picture the entire process for a finite system. These results pertain to the release of drugs, chemicals, agrochemicals, etc., from delivery systems. (C) 2003 American Institute of Physics.

After an introduction to the issue of indexicals, the paper adumbrates the approaches of certain philosophers, mainly D. Kaplan and G. Evans. After criticizing some aspects of those approaches and agreeing with others, it puts forward a view that can be characterized as Fregean. According to that view, whenever an indexical is uttered, the content (or sense) of the utterance is bipolar: it consists partly in the entity referred to and partly in a way in which one can think of the entity and which involves the particular utterance. As the way of thinking involves the utterance, the content is different whenever an indexical is used, whether the indexical is the same or not. On the other hand, as the content includes the reference, it does not coincide with the content of any definite description; the reference of a definite description is not part of its content.

We report herein a case of a 20-year-old previously healthy man who presented, 25 days after the onset of clinically and serologically confirmed Epstein-Barr virus (EBV) infectious mononucleosis, Fusobacterium necrophorum septicemia. The diagnosis of postanginal septicemia was confirmed by repeated demonstration of fusiform, obligate anaerobic, Gram-negative bacilli in anaerobic blood cultures, identified as F. necrophorum 15 days after admission. This case report aims at underlining the need of taking into consideration the possibility of severe Fusobacterium septicemia in previously healthy patients following EBV infectious mononucleosis in order to prevent increased mortality and morbidity.

The primary cause of Duchenne muscular dystrophy (DMD) is a mutation in the dystrophin gene, leading to absence of the corresponding protein, disruption of the dystrophin-associated protein complex, and substantial changes in skeletal muscle pathology. Although the primary defect is known and the histological pathology well documented, the underlying molecular pathways remain in question. To clarify these pathways, we used expression microarrays to compare individual gene expression profiles for skeletal muscle biopsies from DMD patients and unaffected controls. We have previously published expression data for the 12,500 known genes and full-length expressed sequence tags (ESTs) on the Affymetrix HG-U95Av2 chips. Here we present comparative expression analysis of the 50,000 EST clusters represented on the remainder of the Affymetrix HG-U95 set. Individual expression profiles were generated for biopsies from 10 DMD patients and 10 unaffected control patients. Two methods of statistical analysis were used to interpret the resulting data (t-test analysis to determine the statistical significance of differential expression and geometric fold change analysis to determine the extent of differential expression). These analyses identified 183 probe sets (59 of which represent known genes) that differ significantly in expression level between unaffected and disease muscle. This study adds to our knowledge of the molecular pathways that are altered in the dystrophic state. In particular, it suggests that signaling pathways might be substantially involved in the disease process. It also highlights a large number of unknown genes whose expression is altered and whose identity therefore becomes important in understanding the pathogenesis of muscular dystrophy.

Purpose: To investigate the possibility of measuring the gene-specific DNA damage after therapeutic exposure to nitrogen mustards and to examine its relationship with the clinical response. Experimental Design: The kinetics of gene-specific monoadducts and interstrand cross-link formation/repair were measured in the p53 and N-ras genes. DNA extracted from human peripheral lymphocytes following in vitro exposure to melphalan or therapeutic exposure to melphalan or cyclophosphamide was used. Results: When lymphocytes were treated in vitro with biologically relevant doses of melphalan, monoadducts accumulated rapidly in both p53 and N-ras genes, reaching maximal levels within 2 h, whereas the highest interstrand cross-link levels were found within 8 h. Thereafter, the adducts were repaired with half-lives of 14.5 ± 0.3 h (p53) or 18.8 ± 1.5 h (N-ras) for monoadducts and 12.4 ± 0.8 h (p53) or 14.1 ± 2.2 h (N-ras) for interstrand cross-links. Moreover, peak levels of monoadducts in both genes were observed 2 h after treatment in peripheral leukocytes from patients with multiple myeloma treated with high-dose i.v. melphalan, supported by autologous stem cell transplantation, whereas interstrand cross-links were maximal within 8 h. Of seven patients examined, the three who showed the least levels of DNA damage did not respond to the high-dose melphalan. Conclusions: This is the first report showing that it is feasible to measure gene-specific DNA damage in a readily accessible tissue of humans exposed to bifunctional alkylating drugs and to examine, at the level of the individual patient, the relationships between the induction/repair of cytotoxic DNA damage and clinical response or long-term complications.

The current case study provided an unusual setting to track the evolution of HIV-1 envelope gene over a maximum period of 6 years in two asymptomatic spouses undergoing suppressive highly active antiretroviral therapy. For this purpose, proviral DNA samples taken from uncultured peripheral blood mononuclear cells and spanning the C2-V5 regions of env were analyzed at three sampling points per subject. Two distinct topological patterns were observed in the phylogenetic reconstructions of the genetically linked sequences of the couple: an intermingled pattern and a sequentially shifting pattern in the virus populations of the male index case and his spouse, respectively. Application of three evolutionary models for the amino acid-encoded sites, using the maximum likelihood approach, indicated the operation of positive selection in the region only at the second time point in the woman, before receiving therapy. These findings reinforce the evidence of a crucial role for host-selective constraints on HIV-1 env evolution in vivo.

In this paper we are examining Salamina island from a physical-geographical anda geomorphological aspect. For the purposes of this study, we used all existed official maps, recent aerial photographs and satellite image as well as data deriving from extensive fieldwork at the study area. The results of the photo-interpretence are combined and correlated with the outcome of the primary data (physical, geological, geomorphological) that were collected through fieldwork, which took place with the use of GPS, to ensure the accuracy of the measurements. This study resulted to the creation of a geomorphological map of the study area in a GIS environment, along with several thematic maps presenting all collected data (primary and secondary). Finally, a geomorphological and environmental evolution of the study area has taken place, in order to map the genesis of the nowadays morphology.

The main purpose of this paper, is to study the geomorphological evolution of Meganisi island’s coastal zone and to detect areas vulnerable to coastal erosion.The geomorphology of the island is effected by the lithological configuration, the tectonic characteristics, the wider seismotectonic status and the sea activity of the area. The wider area is characterized by intense seismicity: strong earthquakes are very frequent (M>6) and from the seismotectonic point of view is very complex. Limestone is the main lithological formation of Meganisi coastal zone. Coastline is steep and straight with morphological slopes ranging from 0%-66%. A big part of the area (40,87%) is of high slope (>20%). A GIS was developed using data deriving from detailed inland and sea fieldwork, aerial photos, satellite images and pre existing maps. Data were analysed statistically and geographically and variousthematic maps were created such as the morphological map, map of vulnerability, etc. Data deriving from this analysis as well as from fieldwork were processed through logical rules in order to locate zones of high erosion risk. Finally, an erosion risk map was developed in order to locate those areas that are vulnerable to futureerosion and to keep attention to them.

The synoptic scale atmospheric circulation prevailing during hail days in Northern Greece is examined for a period of 26 years (1976-2001) during the warm season. The initial objective of this classification scheme is to serve as a predictive tool for hail forecasting and permit a specification of greater or lesser hail risk, within the forecast activities of the Greek National Hail Suppression Program. The atmospheric circulation was classified into seven synoptic types and their frequency distribution was examined on an annual and monthly basis. Southwesterly flow (SW) and Shortwave trough (SWT) appear to be the most conducive synoptic types for hailstorm activity. Furthermore, the thermodynamic environment favoring the hailstorm development and evolution was examined using selected instability indices. The frequency distribution of the instability indices for a period of 11 years (1991-2001) in association with the synoptic types demonstrated their performance as a forecasting aid for thunderstorm activity to occur in a given synoptic environment.

We report three patients with solitary bone plasmacytoma (SBP) who developed either local recurrence within the radiotherapy field or an isolated distal recurrence and who were treated with high dose therapy supported by autologous stem cell transplantation. All patients remain without evidence of disease for 4-10 years after the procedure. High dose therapy may be of value and require further study in patients with SBP who develop local or distant failure.

We demonstrate that hydromagnetic acceleration can be the driving mechanism of relativistic outflows in AGNs as well as in Gamma-ray burst sources and Crab-like pulsars. Using semianalytical solutions of the full set of the steady, axisymmetric, ideal hydromagnetic equations in flat spacetime—i.e., solving the momentum equation along the flow as well as in the transfield direction—we model the acceleration of relativistic outflows. We find that a Poynting-flux dominated flow near the source reaches equipartition between matter and magnetic energy-fluxes, or even becomes completely matter-dominated (as in the case of Crab-like pulsar winds).

Recombination plays a pivotal role in the evolutionary process of many different virus species, including retroviruses. Analysis of all human immunodeficiency virus type 1 (HIV-1) intersubtype recombinants revealed that they are more complex than described initially. Recombination frequency is higher within certain genomic regions, such as partial reverse transcriptase (RT), vif/vpr, the first exons of tat/rev, vpu and gp41. A direct correlation was observed between recombination frequency and sequence similarity across the HIV-1 genome, indicating that sufficient sequence similarity is required upstream of the recombination breakpoint. This finding suggests that recombination in vivo may occur preferentially during reverse transcription through the strand displacement-assimilation model rather than the copy-choice model.

Influence of water molecule coordination on the magnetic properties of polyamine copper dinitrate complexes was studied. It was found that the magnetic coupling between Cu2+ ions strongly depends on the presence of water molecules in the crystal structure. Electron paramagnetic resonance (EPR) measurements showed considerable temperature dependence of the Lande′ splitting factors and resonance linewidths for both complexes at low temperatures.

Optical Interferometry can play an important role in modern astronomy. Extrasolar planet and binary star research, are some of the fields, where we will face important discoveries in the future. For the VLTI this will be a real challenge, since it will be the pioneer in angular resolution. In addition, high flux sensitivity will help detecting not only Jupiter-sized planets, but Earth-sized planets too. The ability of the VLTI in detecting new planets, measuring stellar diameters and stellar proper motions, with the use of such techniques, is presented.

The effects of retardation in the Coulomb excitation of radioactive nuclei in intermediate energy collisions (Elab ? 100 MeV/nucleon) are investigated. We show that the excitation cross sections of low-lying states in 11Be, 38,40,42S, and 44,46Ar projectiles incident on gold and lead targets are modified by as much as 20% due to these effects. The angular distributions of decaying ? rays are also appreciably modified.

Geographical Information Systems are important tools for various scientificaspects. Especially sciences related to cartography and geographical analysis should definitely employ GIS technology. In this study we present an Internet – based GIS that our team developed under MapXtreme platform. This application gives access to numerous web-users through a server that controls both analysis and data retrieval requests. It is a practical and economical method in order to introduce GIS to educational institutions. This Web GIS may operate through a local or wide area network and, apart from educational purposes, offers a low cost information exchange solution between vast numbers of users.

A sample of 1497 carbon stars in the Large Magellanic Cloud (LMC) has been observed in the red part of the spectrum with the 2dF facility on the Anglo-Australian Telescope. Of these, 156 have been identified as J-type (i.e. 13C-rich) carbon stars using a technique which provides a clear distinction between J stars and the normal N-type carbon stars that comprise the bulk of the sample, and yields few borderline cases. A simple two-dimensional classification of the spectra, based on their spectral slopes in different wavelength regions, has been constructed and found to be related to the more conventional c and j indices, modified to suit the spectral regions observed. Most of the J stars form a photometric sequence in the K- (J-K) colour-magnitude diagram, parallel to and 0.6 mag fainter than the N-star sequence. A subset of the J stars (about 13 per cent) are brighter than this J-star sequence; most of these are spectroscopically different from the other J stars. The bright J stars have stronger CN bands than the other J stars and are found strongly concentrated in the central regions of the LMC. Most of the rather few stars in common with Hartwick and Cowley's sample of suspected CH stars are J stars. Overall, the proportion of carbon stars identified as J stars is somewhat lower than has been found in the Galaxy. The Na D lines are weaker in the LMC J stars than in either the Galactic J stars or the LMC N stars, and do not seem to depend on temperature.

Notre étude porte sur la présence des voyageuses européennes notamment françaises (ambassadrices, épouses de diplômates), visitant Constantinople à la fin du XVIIe et au XVIIIe siècle, et sur leur perception de la femme ottomane. Incitées par leur curiosité et motivées par des intérêts politiques, les voyageuses ont rencontré des sultanes et des femmes de la haute société ottomane. Leur visite des harems orientaux leur a notamment permis de parler du monde derrière le voile. Impressionnées par la richesse de leur costume, le nombre des femmes de leur suite et le luxe de leurs appartements, les voyageuses européennes ont commmuniqué leurs impressions sur l’apparence extérieure, le comportement, les moeurs et la polygamie ottomane. De plus, les voyageuses se sont référées à la situation financière des femmes de la haute société ottomane. Leur contact avec les femmes ottomanes leur a permis de former une opinion personnelle, souvent étrange puisque certaines voyageuses ont parlé de la liberté dont elles jouissaient malgré leur réclusion. Leurs descriptions et présentations ont révélé au public occidental une réalité différente, qui a été à l’origine des réfléxions sur la place de la femme dans la société occidentale.

Les concours d’entrée aux ENS de Sèvres et d’Ulm, comme les agrégations féminines (considérées comme inférieures à celles des hommes) sont des examens qui, ayant survécu jusque dans les années 1970 et 1980, attestent de l’existence d’un «  genre des concours  ». La question de la fusion des concours masculins et féminins est pour la première fois posée entre les deux guerres. La relecture de cette histoire permet de mettre en évidence les hésitations et les réticences qui ont voué pendant plus de soixante ans le projet initial à l’échec.  The existence of a specifically feminine agrégation (which was considered inferior to the male exam), as well as the separation by sexes that existed in the entrance examinations to the superior normal schools of Sèvres and Ulm  attest to the gendered nature of these examinations. The question of uniform entrance examinations for both sexes was originally posed in the period between the wars. Examining the history of these exams reveals how hesitations and doubts for over 60 years condemned the original proposal to failure.

The first complete I-filter light curve of the eclipsing sdB binary HS 0705+6700 is analyzed using the Wilson-Devinney code and new geometric and photometric elements are derived. Using these elements together with the available spectroscopic data, it was possible to build a detailed model of the system. Our results are in good agreement with those found from photometric studies in other bands.

19 carbon stars that show lithium enrichment in their atmospheres have been discovered among a sample of 674 carbon stars in the Large Magellanic Cloud. Six of the Li-rich carbon stars are of the J type, i.e. they show strong 13C isotopic features. No super-Li-rich carbon stars were found. The incidence of lithium enrichment among carbon stars in the LMC is much rarer than in the Galaxy, and about five times more frequent among J-type than among N-type carbon stars. The bolometric magnitudes of the Li-rich carbon stars range between -3.3 and -5.7. Existing models of Li-enrichment via the hot bottom burning process fail to account for all of the observed properties of the Li-enriched stars studied here.

Multiwall carbon nanotubes were studied by dc magnetization and electron spin resonance (ESR) measurements. Hole doping is inferred from both the high-field dc susceptibility and ESR parameters complying favorably with the band model of two-dimensional graphite. Paramagnetic deviations are evinced on the diamagnetic susceptibility at weak fields and low temperatures, conforming qualitatively with the Aharonov-Bohm effect on the energy gap for magnetic field parallel to the tube axis. Comparison with theoretical predictions for ensembles of carbon nanotubes reveals appreciable differences, indicative of the diverse distribution of nanotubes as well as the presence of active doping. © 2003 The American Physical Society.

{Single crystal of erbium doped La3Ga5.5Ta 0.5O14 grown by the Czochralski method have been investigated by electron paramagnetic resonance and dielectric spectroscopy methods. Dielectric permittivity ε measurements performed in 90-440 K temperature range have shown negligible dispersion for 1 kHz - 1 MHz frequencies and a Curie-Weiss type behaviour with C = 47700 K and θ = -340 K. Electron paramagnetic resonance studies have revealed the presence of two different paramagnetic, monoclinic centres. The calculated g factor values are: g1 = 1.449

The target of this study was the development of mathematical models that best describe the behaviour of respiratory parameters. First of all, we studied lung volume in relation to time both for normal and maximal inspiration/expiration by developing mathematical models. For the construction of these equations the exponential model was used. Then we tried to study the flow-volume of a typical spirometer curve by dividing it into two parts: the first part reaches the Peak Expiratory Flow (PEF) point and the second follows until the volume reaches Vital Capacity (VC). For the first part we built an exponential equation; for the second part a number of existing prediction equations for the flow in various points of VC were used. For the volume-pressure diagram, we built exponential equations that describe the volume-pressure relation below Vo (Vo: lung volume where pressure is zero). The equations were coupled for expiration and inspiration. The modeling of respiratory mechanics led us to the conclusion that the developed models could offer new potentials in the description of other respiratory parameters as well.

Purpose. To investigate the relationship between mean dissolution time (MDT) and dose/solubility ratio (q) using the diffusion layer model. Methods. Using the classic Noyes-Whitney equation and considering a finite dose, we derived an expression for MDT as a function of q various conditions. q was expressed as a dimensionless quantity by taking into account the volume of the dissolution medium. Our results were applied to in vitro and in vivo data taken from literature. Results. We found that MDT depends on q when q < 1 and is infinite when q > 1 and that the classic expression of MDT = 1/k, where k is the dissolution rate constant, holds only in the special case of q = 1. For the case of perfect sink conditions, MDT was found to be proportional to dose. Using dissolution data from literature with q < 1, we found better estimates of MDT when dependency on dose/solubility ratio was considered than with the classic approach. Prediction dissolution limited absorption was achieved for some of the in vivo drug examples examined. Conclusion. The mean dissolution time of a drug depends on dose/solubility ratio, even when the model considered is the simplest possible. This fact plays an important role in drug absorption when absorption is dissolution limited.

The first authenticated example of migration of a methyl group from palladium(ii) to a coordinated N-heterocyclic carbene is described. © 2003 The Royal Society of Chemistry.

By using relativistic, axisymmetric, ideal MHD, we examine the motion of the baryon/e+/-/ photon fluid that emanates from a stellar-mass compact object/debris-disk system (a common outcome of many progenitor models). We prove that the motion can be described as a frozen pulse, which permits the study of each shell of the pancake-shaped outflow using steady-state equations. The ejected energy flux is dominated by the electromagnetic (Poynting) contribution, but it can also have a nonnegligible e+/-/radiation (thermal fireball) component. We demonstrate, through exact self-similar solutions, that the flow is first thermally and subsequently magnetically accelerated up to equipartition between kinetic and Poynting fluxes, i.e., ~ 50% of the total energy is converted into baryonic kinetic energy. The electromagnetic forces also collimate the flow, reaching a cylindrical structure asymptotically.

By using relativistic, axisymmetric, ideal MHD, we examine the motion of the baryon/e±/ photon fluid that emanates from a stellar-mass compact object/debris-disk system (a common outcome of many progenitor models). We prove that the motion can be described as a frozen pulse, which permits the study of each shell of the pancake-shaped outflow using steady-state equations. The ejected energy flux is dominated by the electromagnetic (Poynting) contribution, but it can also have a non negligible e±/radiation (thermal fireball)component. We demonstrate, through exact self-similar solutions, that the flow is first thermally and subsequently magnetically accelerated up to equipartition between kinetic and Poynting fluxes, i.e., ∼ 50% of the total energy is converted into baryonic kinetic energy. The electromagnetic forces also collimate the flow, reaching a cylindrical structure asymptotically.

Materials are distributed throughout the body of mammals by fractal networks of branching tubes. Based on the scaling laws of the fractal structure, the vascular tree is reduced to an equivalent one-dimensional, tube model. A dispersion-convection partial differential equation with constant coefficients describes the heterogeneous concentration profile of an intravascular tracer in the vascular tree. A simple model for the mammalian circulatory system is built in entirely physiological terms consisting of a ring shaped, one-dimensional tube which corresponds to the arterial, venular, and pulmonary trees, successively. The model incorporates the blood flow heterogeneity of the mammalian circulatory system. Model predictions are fitted to published concentration-time data of indocyanine green injected in humans and dogs. Close agreement was found with parameter values within the expected physiological range. (C) 2003 Biomedical Engineering Society. {[}DOI: 10.1114/1.1555627].

Coastal areas are the result of a complex interaction of many factors such as rock properties, geomorphological processes and wave action. We approach these dynamic landscapes using fuzzy set theory. As input variables we use rock’s erodibility, slope gradient, (drainage density,) vegetation and land use and wave characteristics. Next we formulate fuzzy logical rules to transform input variables to output ones. The output of the system represents the coastal depositional and erosional processes. As a case study we choose the island of Corfu (Greece) which presents lithologies very vulnerable to erosion and receives very high amount of rainfalls, in relation to the rest of the Greek territory. All this procedure has been developed using a loose coupling system of a flexible GIS platform and the proper environment to process fuzzy variables.

We discuss the results of modeling the TeV γ-ray spectra of two active galactic nuclei, Mrk 501 and Mrk 421, that have almost the same redshifts: z=0.031 and 0.034, respectively. The effect of intergalactic γ-ray absorption is treated as an uncertainty in the measurement of the intrinsic spectrum. Although the objects differ, we obtain satisfactory fits for both of them in a synchrotron self-Compton scenario. Compared to previous models, our fits are characterized by higher values of the Doppler factor (δ>=50) and an electron injection spectrum extending to higher energies (γmax>=1.5×105). In the case of Mrk 421, the observed difference in spectral slope in X-rays and TeV γ-rays between the high and low states can be explained as a variation of a single parameter-the maximum energy γmaxmc2 at which electrons are injected.

Erhard s wall lizard, Podarcis erhardii (Sauria: Lacertidae), is highly diversified in Greece and especially in the southern Aegean region. Out of the 28 recognized subspecies, 27 are found in Greece from the North Sporades island-complex in the North Aegean (grossly south of the 39th parallel) to the island of Crete in the South. The species exhibits great morphological and ecological plasticity and inhabits many different habitats from rocky islets and sandy shores to mountaintops as high as 2000m. By examining intraspecific variability at a segment of the mitochondrial gene cytochrome b we have found that that extant populations of P. erhardii are paraphyletic. Furthermore, we have found that subspecies previously defined on the basis of morphological characteristics do not correspond to different molecular phylogenetic clades, so that their status should be reconsidered. The DNA based biogeographical and phylogenetic history of Podarcis in Southern Greece is congruent with available paleogeographic data of the region, which supports the view that DNA sequences may be a useful tool for the study of palaeogeography.

Three patients, 2 women and 1 man, with primary (AL) amyloidosis without congestive heart failure are described; all 3 patients presented reduced I-123 metaiodobenzylguanidine(MIBG) myocardial uptake suggesting marked cardiac sympathetic denervation. This is the first time myocardial adrenergic denervation is described in patients with AL amyloidosis without evidence of congestive heart failure; the observed denervation could be implicated in the pathogenesis of cardiac conduction disturbances which are common in this disease.

This study is dealing with the natural environment of the coastal zone of Paros island chosen as a representative ‘sample’ of the Cyclades complex of islands and amongst the most touristic ones. More than 75% of the coastal zone consists of high and lower cliffs, whilst relatively flat (slopes <2,5%) coastal plains do not exceed the 17% of the coastline. The island receives a considerable amount of wave energy; this has its highest values (>1500 W/m) at the NE part of the island and its lowest at the SE “protected” and shallower shelf area. Touristic (sandy/pebble) beaches have been developed along those parts of the coastline characterized by Quaternary (erodible) lithology associated with moderate wave activity. Sea level rise during the Holocene has played also an important role in coastal geomorphology; for example, Paros was connected to Naxos and Antiparos islands 10.000 yr BP and to Antiparos 6000 yr BP. A further rise of sea level (some 0,5 m at the year 2100) due to climatic changes will obviously deteriorate the terrestrial part of the coastal environment and especially all the touristic beaches and related establishments along its coastline.

The neutron diffraction patterns of Mg2FeV3O 11-δ compound at various low temperatures have been investigated. No magnetic ordering was observed in the investigated temperature range down to 10K. These materials have been formed in the triclinic space group but there are specific differences in the positions of atoms as compared to previously determined from XRD method. The iron(III) ions are distributed non-statistically with magnesium(II) ions and this could be responsible for some differences in the structure of the above sample. The method of sample preparation, in particularly thermal annealing processes could be responsible for the differences.

We demonstrate that ``hot'' MHD outflows from neutron-rich black hole debris disks can significantly alleviate the baryon-loading problem in gamma-ray burst sources. We argue that the neutron-to-proton ratio in disk-fed outflows might be as high as ~30 and show, with the help of an exact semianalytic relativistic-MHD solution, that the neutrons can decouple at a Lorentz factor γd~15 even as the protons continue to accelerate to γ∞~200 and end up acquiring ~30% of the injected energy. We clarify the crucial role that the magnetic field plays in this process and prove that purely hydrodynamic outflows must have γd>~few×102. The motion of the decoupled neutrons is not collinear with that of the decoupled protons, so, in contrast to previous suggestions based on purely hydrodynamic models, the two particle groups most likely do not collide after decoupling. The decoupled neutron flow might nevertheless contribute to the observed afterglow emission.

We demonstrate that ``hot'' MHD outflows from neutron-rich black hole debris disks can significantly alleviate the baryon-loading problem in gamma-ray burst sources. We argue that the neutron-to-proton ratio in disk-fed outflows might be as high as ~30 and show, with the help of an exact semianalytic relativistic-MHD solution, that the neutrons can decouple at a Lorentz factor γd~15 even as the protons continue to accelerate to γ∞~200 and end up acquiring ~30% of the injected energy. We clarify the crucial role that the magnetic field plays in this process and prove that purely hydrodynamic outflows must have γd>~few×102. The motion of the decoupled neutrons is not collinear with that of the decoupled protons, so, in contrast to previous suggestions based on purely hydrodynamic models, the two particle groups most likely do not collide after decoupling. The decoupled neutron flow might nevertheless contribute to the observed afterglow emission.

A study was performed on the optical nanowriting on azobenzene side-chain polymethacrylate thin films using near-field scanning optical microscopy (NSOM). The optical storage mechanism in azobenzene side-chain polymers is based on the isomerization cycles of the azobenzene side-chains between their cis and trans forms. The optical anisotropy was detected by coupling the red light at 690 nm with modulated polarization to the NSOM aperture.

Cet article traite de l’apparence extérieure des Orientaux. Il est notamment question de la contribution de la littérature et de l’iconographie viatiques du XVIIIe siècle à la formation de l’image exotique de l’Oriental. S’appuyant sur la mode et les caractéristiques physiques des populations de l’Orient méditerranéen, les voyageurs français essayèrent d’une certaine manière de matérialiser l’Autre et l’Ailleurs. Les commentaires des voyageurs révèlent souvent leurs préjugés ainsi que leur tendance à la généralisation. En effet, la mode orientale, peu conforme aux usages européens, fut jugée sévèrement. Notons néanmoins que si les voyageurs furent critiques de la mode orientale, certaines de ses particularités les incitèrent à remettre en question la mode occidentale. Quoi qu’il en soit, la littérature des voyages créant une image stéréotypée des Orientaux, facilita leur identification.

This study addresses the utility of pharmacodynamic considerations to the assessment of bioequivalence (BE) studies. A novel methodology was developed and the performance of classic, nonclassic and novel BE indices was evaluated using extensive simulations of BE trials generated from a classic pharmacokinetic (PK)/pharmacodynamic (PD) model. Three novel indices based on drug's pharmacodynamics were developed and served as criteria for the assessment of all BE indices. Modified power curves were constructed and used for the analysis of BE trials from a PD point of view. All BE indices of either purely PK or PD nature were classified in a semiquantitative manner according to their strictness in declaring BE. The partial area until the peak concentration followed by the two newly proposed metrics (MARD, MARD(w1)) exhibited the most strict performance in declaring BE irrespective of the PK scenarios examined. The study opens new avenues in BE assessment since it places more emphasis on the PD aspects of the formulations. (C) 2003 Elsevier Science B.V. All rights reserved.

Background: This multicenter, prospective phase II study evaluated the safety and efficacy of the combination of docetaxel and vinorelbine in patients with platinum-resistant, paclitaxel-pretreated recurrent ovarian cancer. Patients and methods: Treatment consisted of vinorelbine 25 mg/m2 as a 20-min i.v. infusion (days 1 and 8), and docetaxel 70 mg/m2, as a 1-h i.v. infusion (day 8). Granulocyte colony-stimulating factor support was administered prophylactically on days 12-16. Treatment was repeated every 21 days. Results: Forty-six patients were enrolled. The median number of previous chemotherapeutic regimens was one (range 1-3) with a median treatment-free interval of 4.3 months. Four chemotherapy cycles per patient were administered. Almost 75% of the planned doses for both drugs were given. Forty-one patients are evaluable for response. Three patients (6.5% of all patients; 7.3% of evaluable patients) achieved complete response and eight (17.4% and 19.5%, respectively) a partial response to chemotherapy leading to overall response rates of 23.9% and 26.8%, respectively. Another 34.8% (39.0%) had stable disease. At a median follow-up of 30 months, the median disease-free survival was 13 months, relapse-free survival was 5 months, time to progression was 4.5 months, and overall survival was 9.3 months. Severe toxicities included leukopenia (31%), neutropenia (35%) and febrile neutropenia (20%). Conclusions: The combination of docetaxel/vinorelbine is an effective regimen with manageable toxicity for the treatment of platinum-resistant, paclitaxel-pretreated ovarian cancer.

The paper presents combined spectroscopic and photometric orbital solutions for four close binary systems: SW Lyn, QW Gem, AP Leo and V2150 Cyg. The photometric data are new, while the spectroscopy has been recently obtained within the radial velocity programme at the David Dunlap Observatory. This paper is the first in the planned series of investigations. We give an extensive description of the motivation for the series and of the main assumptions made in our solutions. The four targets of this investigation span a range of typical configurations and thus present different levels of difficulty for the combined spectroscopic and photometric orbital solutions.

The purposes of this study were to (i) re-examine the relevance of Higuchi equation and the power la Using both simulated and experimental release data in conjunction with the linearized. in tern's of t(1/2). percent of drug release plots. (ii) demonstrate that the power law describes the entire drug release profile of several experimental data, and (iii) point out a physically based hypothesis for the Successful Use Of power law in describing the entire drug release profile. Simulated data generated from the equation of power law were further analyzed using linear regression analysis in accord with the Higuchi equation. The analysis revealed that data generated from the equation Of power law can be misinterpreted as obeying the Higuchi equation. The use of power law in describing the entire drug release curie from HPMC-based matrix tablets is validated by direct fit of power law equation to published data of other authors. A hypothesis based on the nonclassical diffusion of the solutes in the HPMC matrices is used to interpret the successful use of the power law in describing the entire release profile. (C) 2003 Elsevier Science B.V, All rights reserved.

In order to investigate the potential relationship between erythromycin resistance and specific M-serotypes among clinical isolates of Streptococcus pyogenes from children in Greece, we randomly selected a total of 49 erythromycin-resistant (EryR) and 21 erythromycin-susceptible (EryS) isolates from the 1158 S. pyogenes isolates from the two main children's hospitals of Athens during the period October 1997 to October 1998. The isolates were further characterized by M-serotyping, examined for their susceptibility to penicillin, vancomycin and clindamycin, and categorized into resistance phenotypes. A total of 248 (21%) S. pyogenes isolates in the two main children's hospitals of Athens during the study period were resistant to erythromycin. All 49 EryR and 21 EryS isolates were susceptible to penicillin and vancomycin. With respect to erythromycin and clindamycin resistance, phenotypes M and IR MLSB dominated, with 30 and 17 isolates, respectively, two isolates belonged to the CR MLSB phenotype. Among the erythromycin resistant isolates, two M serotypes were dominant: M22 (30%) and M84 (41%). More specifically, M22 and M84 were most prevalent in resistance phenotypes IR MLSB (65%) and M (63%), respectively. In the susceptible group, no isolate belonged to these two M-serotypes, nor was a predominant serotype found. In contrast to susceptible isolates, two distinct M-serotypes were highly represented among EryR S. pyogenes isolates and predominantly associated with two distinct phenotypes.

The presence of erm genes conferring constitutive and inducible resistance, as well as that of the mefA gene conferring only constitutive resistance, was investigated using PCR in 70 erythromycin resistant (MIC>or=1 mg/l) strains of viridans group streptococci (VGS) (18 Streptococcus mitis biotype 1, 16 S. mitis biotype 2, 15 S. oralis, 12 S. salivarius and nine S. sanguis) isolated from the oropharynx of healthy Greek children. All of the 56 isolates belonging to resistance phenotype M harbored the mefA gene. All of the 14 isolates constitutively resistant to macrolides and lincosamides (phenotype CR) harbored the ermB gene. Co-presence of both genes was not observed, whereas class A erm gene (previously known as ermTR) was not detected. Our results are consistent with a possible role of VGS as a reservoir of resistance genes now prevalent in pathogenic species of streptococci.

Objectives. To study retrospectively CA 125, CD44, and epithelial membrane antigen (EMA) expression in renal cell carcinoma and their role as prognostic factors. CD44 is a cell adhesion molecule, and CA 125 and EMA are tumor-associated antigens used in the diagnosis and monitoring of the outcome and response to treatment of various human malignancies. Their expression and prognostic significance after resection of renal cell carcinoma have not been adequately studied. Methods. The expression of CA 125, CD44, and EMA were studied immunohistochemically and correlated with the outcome of 92 patients who underwent nephrectomy for renal cell carcinoma. Results. Positive staining was found for CA 125 in 28 patients (30.43%), CD44 in 48 patients (52.17%), and EMA in 74 patients (80.43%). CA 125 expression was increased in those with higher T stage (P <0.001) and histologic grade (P = 0.007). An inverse relationship was found between EMA expression and grade (P <0.001). The median follow-up was 41.5 months (range 30 to 65). The median survival for positive and negative patients was 34.6 versus 54.3 months for CA 125 (P = 0.0044), 48.3 versus 51.5 months for CD44 (P = 0.4677), and 53.2 versus 34 months for EMA (P = 0.0046). Multivariate analysis showed that CA 125 and EMA expression were independent prognostic factors (P = 0.021 and P = 0.018, respectively). Subgroup analysis showed that CA 125 expression predicted a significantly higher probability of death (28.6% versus 8%, P =0.0413) in patients with T1 or T2 tumors. Conclusions. CA 125 and EMA appear to be useful prognostic markers in renal cell carcinoma. Additional studies are needed to determine the value of these markers as a means of selection for postoperative management. © 2003 Elsevier Inc.

BACKGROUND: Activation of T lymphocytes is thought to mediate myocardial dysfunction in dilated cardiomyopathy (CMP), probably through cytotoxic cytokines, but its value as a prognostic factor has not been evaluated. METHODS: For 2 years we prospectively followed 76 patients (65 males, 11 females, age 49 +/- 7 years) with CMP and New York Heart Association(NYHA) Class II-III heart failure; left ventricular (LV) function was assessed echocardiographically. Thirty-three patients (28 males, five females, age 52 +/- 6 years) with ischaemic heart disease (IHD) and similar NYHA and LV function characteristics were used as controls. Serum sIL-2R levels, peripheral blood lymphocyte proliferation (basal, + concanavalin A) and HLA-DQB1 genotyping was carried out in all patients. RESULTS: The CMP patients had increased sIL-2R levels (1259 +/- 130 pg mL-1) compared with the IHD patients (703 +/- 80 pg mL-1, P < 0.01, only 3 > 800 pg mL-1). In the CMP patients, there was a significant (r = +0.45, P= 0.04) correlation between sIL-2R and the LV end-diastolic diameter but not with the LV ejection fraction or NYHA Class. During the 24-month follow up, 17 of the CMP patients had an adverse clinical course (death, need for cardiac transplantation, or worsening heart failure). Of these, 14 (75%) had elevated (>or= 800 pg mL-1) sIL-2R levels (Group I) compared with only five (6%) with a stable clinical course (Group II). Neither [3H] thymidine incorporation into the peripheral blood lymphocytes nor the excess of HLA-DQB1-30 histidine homozygotes in the Group I patients (38% vs. 17%, P < 0.05) could predict the clinical outcome. CONCLUSION: Increased sIL-2R levels in CMP patients are an independent predictor of a more aggressive clinical course

Background: The combination of vincristine and doxorubicin administered as a continuous infusion via an indwelling catheter together with intermittent high-dose dexamethasone (VAD) is an effective primary treatment for patients with symptomatic multiple myeloma. In order to avoid the need for an indwelling catheter, which imposes logistic problems for outpatient administration, several phase II studies have explored the feasibility and efficacy of VAD-like outpatient regimens. We designed a prospective randomized study to compare the objective response rates of two VAD-like outpatient regimens as primary treatment for symptomatic patients with multiple myeloma. Patients and methods: Patients were entered in a randomized study regardless of age, performance status and renal function. One hundred and twenty-seven patients received VAD bolus, which consisted of vincristine 0.4 mg i.v., doxorubicin 9 mg/m2 i.v. and dexamethasone 40 mg p.o. daily for four consecutive days and 132 patients received VAD doxil, which consisted of vincristine 2 mg i.v. and liposomal doxorubicin 40 mg/m2 i.V. on day 1 and dexamethasone 40 mg p.o. daily for 4 days. The two regimens were administered every 28 days for four courses and in courses 1 and 3, in both arms, dexamethasone was also given on days 9-12 and 17-20. Results: An objective response was documented in 61.4% and 61.3% of patients treated with VAD bolus and VAD doxil, respectively. Hematological and non-hematological toxicities were mild or moderate and equally distributed between the two treatment arms with the exception of alopecia, which was more common after VAD bolus, and of palmar-plantar erythrodysesthesia, which was more common after VAD doxil. Conclusions: Our multicenter trial, which included an unselected patient population, indicated that both VAD bolus and VAD doxil can be administered to outpatients and can provide an equal opportunity of rapid response in many patients with multiple myeloma.

Το βιβλίο "Φιλοσοφικές έννοιες στη Φυσική" παρουσιάζει την ανάπτυξη της επιστήμης της Φυσικής σε σχέση με το ιστορικό και φιλοσοφικό πλαίσιο μέσα στο οποίο αυτή συντελέστηκε.Μέσα από τις σελίδες του, δίνεται η ευκαιρία στον αναγνώστη να στοχαστεί σχετικά με τη φύση του επιστημονικού εγχειρήματος την οποία μπορεί να είχε προσεγγίσει νωρίτερα μέσα από το πρίσμα της παραδοσιακής ιστορίας της επιστήμης και μέσα από μια σειρά μαθημάτων στις φυσικές επιστήμες.Στόχος του είναι να εντυπώσει στον αναγνώστη τον ουσιαστικό ρόλο τον οποίο έχουν διαδραματίσει οι φιλοσοφικές θεωρήσεις σε ό,τι αφορά την επιστημονική πρακτική και την κατασκευή των επιστημονικών θεωριών.Αντίθετα με την αρκετά διαδεδομένη άποψη ότι η Φυσική και η Φιλοσοφία είναι απομακρυσμένες η μία από την άλλη, αυτό το βιβλίο περιγράφει τη συνεχή αλληλεπίδραση που είχαν και συνεχίζουν να έχουν.Μέσα στις σελίδες του βιβλίου η συζήτηση για τα κύρια φιλοσοφικά ζητήματα εδράζεται στο συγκεκριμένο ιστορικό πλαίσιο και στο περιεχόμενο της αντίστοιχης επιστημονικής δραστηριότητας. [...]

Purpose. To develop a quantitative biopharmaceutics drug classification system (QBCS) based on fundamental parameters controlling rate and extent of absorption. Methods. A simple absorption model that considers transit flow, dissolution, and permeation processes stochastically was used to illustrate the primary importance of dose/solubility ratio and permeability on drug absorption. Simple mean time considerations for dissolution, uptake, and transit were used to identify relationships between the extent of absorption and a drug's dissolution and permeability characteristics. Results. The QBCS developed relies on a ( permeability, dose/ solubility ratio) plane with cutoff points 2 x 10(-6) - 10(-5) cm/s for the permeability and 0.5 - 1 (unitless) for the dose/ solubility ratio axes. Permeability estimates, P-app are derived from Caco-2 studies, and a constant intestinal volume content of 250 ml is used to express the dose/ solubility ratio as a dimensionless quantity, q. A physiologic range of 250 - 500 ml was used to account for variability in the intestinal volume. Drugs are classified into the four quadrants of the plane around the cutoff points according to their Papp, q values, establishing four drug categories, i.e., I (P-app > 10(-5) cm/s, q less than or equal to 0.5), II (P-app > 10(-5) cm/s, q > 1), III (P-app < 2 x 10(-6) cm/s, q <= 0.5), and IV (P-app < 2 x 10(-6) cm/s, q > 1). A region for borderline drugs (2 x 10(-6) < P-app < 10(-5) cm/s, 0.5 < q < 1) was defined too. For category I, complete absorption is anticipated, whereas categories II and III exhibit dose/ solubility ratio - limited and permeability-limited absorption, respectively. For category IV, both permeability and dose/ solubility ratio are controlling drug absorption. Semiquantitative predictions of the extent of absorption were pointed out on the basis of mean time considerations for dissolution, uptake, and transit in conjunction with drug's dose/ solubility ratio and permeability characteristics. A set of 42 drugs were classified into the four categories, and the predictions of intestinal drug absorption were in accord with the experimental observations. Conclusions. The QBCS provides a basis for compound classification into four explicitly defined drug categories using the fundamental biopharmaceutical properties, permeability, and dose/ solubility ratio. Semiquantitative predictions for the extent of absorption are essentially based on these drug properties, which either determine or are strongly related to the in vivo kinetics of drug dissolution and intestinal wall permeation.

This study, explores the utility of quantitative structure-pharmacokinetic relationship models of the disposition parameters: clearance (CL), apparent volume of drug distribution (V-ap), fractal clearance (CLf), and fractal volume (v(f)), for a series of 23 cephalosporins used in therapeutics. Data for CL, V-ap and elimination half-life were obtained from literature, whereas CL, and vf were calculated from the literature data for CL and V-ap, respectively. A variety of descriptors expressing acidity/basicity, lipophilicity, molecular size and hydrogen bonding properties were estimated using computer packages. For each pharmacokinetic parameter, projection to latent structures (PLS) was applied to the total dataset. Adequate PLS models, with one principal component, were derived for CL, CLf, V-ap and v(f). Identical descriptors were found to be significant for the two clearance as well as for the two volume of distribution terms. CL and CLf expressed similar performance while the predictive performance of v(f) was much higher than that of V-ap. Multiple linear and non-linear regression models were developed. The regression results were in agreement with the PLS models. The non-linear models were superior to the relevant linear relationships. The worst models found were for V-ap (R-2 = 0.523 and R-2 = 0.571 for the linear and non-linear model, respectively) and the best models found were for v(f) (R-2 = 0.729 and R-2 = 0.824 for the linear and non-linear model, respectively). (C) 2003 Elsevier B.V. All fights reserved.

A randomized trial was conducted to assess the efficacy of daily (QD) or thrice weekly (TIW) administration of interferon-alpha (IFN) in high doses in combination with ribavirin (1.0-1.2 g/day) in patients with chronic hepatitis C (CHC) who were nonresponders to previous IFN monotherapy. Interferon was administered as 10 MU IFN (QD or TIW) for 4 weeks, followed by 5 MU IFN (QD or TIW) for 20 weeks, and then by 3 MU IFN (QD or TIW) for 24 weeks. Sustained virological response (SVR) was evaluated in 142 patients who received at least one dose of medication. One-fourth of the patients achieved SVR, 26% of those treated with IFN QD and 25% of those treated with IFN TIW (P = 0.85). For genotype 1 patients, SVR rates were 32.4 and 15.8% for IFN QD and IFN TIW, respectively, whereas for genotype non-1 patients the corresponding SVR rates were 20.6 and 36.4%, respectively (test of homogeneity: P = 0.031). This finding was further confirmed by multivariate logistic regression analysis where a statistically significant interaction (P = 0.012) was found between treatment and HCV genotype indicating that the IFN QD regimen was superior to IFN TIW among genotype 1 patients whereas, among genotype non-1 patients, the two treatments were similar (odds ratio of SVR in IFN QD vs IFN TIW: 3.33 among genotype 1 patients, 95% CI: 1.00-11.14). In conclusion, re-treatment of patients not responding to previous IFN monotherapy with a combination of high daily dose of IFN with ribavirin may be beneficial for genotype 1 infected patients.

A randomized trial was conducted to assess the efficacy of interferon-alpha (IFN) daily in combination with ribavirin in 301 naive patients with chronic hepatitis C (CHC). Patients were randomized to receive ribavirin 1.2 g daily (QD) for 48 weeks with either IFN 5 MU (thrice weekly) TIW for 8 weeks followed by IFN 3 MU TIW for 40 weeks (IFN TIW, n = 154) or IFN 5 MU QD for 8 weeks followed by IFN 3 MU QD for 16 weeks followed by IFN 3 MU TIW for 24 weeks (IFN QD, n = 147). Treatment discontinuation rates, because of adverse events, were similar in the two arms (14.9% in IFN TIW and 14.3% in IFN QD, P = 0.87). The proportion of patients with sustained virological response (SVR) was 27.9% for patients treated TIW and 38.8% for those treated QD (P = 0.046). According to logistic regression analysis, patients in the IFN QD arm had 1.7 times higher probability of achieving SVR, than those receiving IFN TIW (P = 0.038). Low baseline viral load (P = 0.017) and genotype non-1 (P = 0.036) were associated with higher SVR rates. Combination of IFN/ribavirin for 48 weeks is more effective when IFN is administered daily for the first 24 weeks in naive patients with CHC.

We demonstrate that a quantum-dot cellular automata device can be fabricated using electron beam lithographically defined gates on GaAs/AlGaAs heterostructure materials, and that by tuning the four quantum dot (J. Phys. C: Solid State Phys. 21 (1988) L893) system polarization of one double dot can lead to polarization in the neighboring double dot (Phys. Rev. B 67 (2003) 033302). The polarization is detected using a 1-D or 0-D channel defined next to one pair of double dots which acts as a non-invasive voltage probe (Phys. Rev. Lett. 70 (1993) 1311). Ultimately a cellular automata device should be isolated from reservoirs to prevent charge fluctuations caused by co-tunneling. The non-invasive voltage probe is used to show that coupled double dots isolated from reservoirs can be made to have a sharper polarization transition. By studying the broadening of the polarization signal from a coupled double dot system isolated from reservoirs, we deduce the charge dephasing times for intra dot scattering to be more than 0.2 ns (Phys. Rev. B 67 (2003) 073302). © 2004 Elsevier Ltd. All rights reserved.

Purpose. To verify the Higuchi law and study the drug release from cylindrical and spherical matrices by means of Monte Carlo computer simulation. Methods. A one-dimensional matrix, based on the theoretical assumptions of the derivation of the Higuchi law, was simulated and its time evolution was monitored. Cylindrical and spherical three-dimensional lattices were simulated with sites at the boundary of the lattice having been denoted as leak sites. Particles were allowed to move inside it using the random walk model. Excluded volume interactions between the particles was assumed. We have monitored the system time evolution for different lattice sizes and different initial particle concentrations. Results. The Higuchi law was verified using the Monte Carlo technique in a one-dimensional lattice. It was found that Fickian drug release from cylindrical matrices can be approximated nicely with the Weibull function. A simple linear relation between the Weibull function parameters and the specific surface of the system was found. Conclusions. Drug release from a matrix, as a result of a diffusion process assuming excluded volume interactions between the drug molecules, can be described using a Weibull function. This model, although approximate and semiempirical, has the benefit of providing a simple physical connection between the model parameters and the system geometry, which was something missing from other semiempirical models.

It is commonly accepted that shot put performance is mainly determined by the ability of the lower body to produce power. The purpose of the present study was to investigate the relationship between shot put performance and triceps brachii muscle fiber type composition and strength capacity. Thirteen male physical education students were selected to participate in the study based upon their shot put performance after 5 weeks of shot put technique instruction. At the completion of this technique-instruction period, they performed the following tests: shot put with a 6-kg shot, isokinetic torque measurements of the elbow extensors at 0, 0.52, 1.04, 1.57, 2.09, 3.14, and 4.19 rad.s(-1), maximal strength (1 RM) and explosive-throwing bench-press tests, one-arm seated shot put with 1-, 2-, 3-, 4-, 5- and 6-kg shot. Whole-body and dominant upper-arm bioimpedance measurements were used to estimate whole-body and upper-arm muscle mass. Muscle biopsy samples from the long head of the dominant triceps brachii were obtained and analyzed for fiber type composition with ATPase histochemistry. Shot put performance was significantly correlated with type II fiber area ( r=0.70, P<0.01), one-arm seated shot put (range r=0.60 to r=0.79, P<0.05), elbow extensors' isokinetic torque (range r=0.65 to r=0.78, P<0.05), bench-press tests ( r>0.86, P<0.01) and estimated arm muscle cross-sectional area ( r=0.68, P<0.05). These results suggest that fiber type composition and the functional capacity of triceps brachii muscle (e.g., isokinetic torque) explain a part of shot put performance. The magnitude of the correlation coefficients between shot put and the upper-body power tests suggests that other body parts (e.g., lower extremities) may play a significant role in this event.

We present a general formulation of special relativistic magnetohydrodynamics and derive exact radially self-similar solutions for axisymmetric outflows from strongly magnetized, rotating compact objects. We generalize previous work by including thermal effects and analyze in detail the various forces that guide, accelerate, and collimate the flow. We demonstrate that, under the assumptions of a quasi-steady poloidal magnetic field and of a highly relativistic poloidal velocity, the equations become effectively time independent and the motion can be described as a frozen pulse. We concentrate on trans-Alfvénic solutions and consider outflows that are super-Alfvénic throughout in the companion paper. Our results are applicable to relativistic jets in gamma-ray burst (GRB) sources, active galactic nuclei, and microquasars, but our discussion focuses on GRBs. We envision the outflows in this case to initially consist of a hot and optically thick mixture of baryons, electron-positron pairs, and photons. We show that the flow is at first accelerated thermally but that the bulk of the acceleration is magnetic, with the asymptotic Lorentz factor corresponding to a rough equipartition between the Poynting and kinetic energy fluxes (i.e., ~50% of the injected total energy is converted into baryonic kinetic energy). The electromagnetic forces also strongly collimate the flow, giving rise to an asymptotically cylindrical structure.

We present exact radially self-similar solutions of special relativistic magnetohydrodynamics representing ``hot'' super-Alfvénic outflows from strongly magnetized, rotating compact objects. We argue that such outflows can plausibly arise in gamma-ray burst (GRB) sources and demonstrate that, just as in the case of the trans-Alfvénic flows considered in the companion paper, they can attain Lorentz factors that correspond to a rough equipartition between the Poynting and kinetic energy fluxes and become cylindrically collimated on scales compatible with GRB observations. As in the trans-Alfvénic case, the initial acceleration is thermal, but, in contrast to the solutions presented in the companion paper, part of the enthalpy flux is transformed into Poynting flux during this phase. The subsequent, magnetically dominated acceleration can be significantly less rapid than in trans-Alfvénic flows.

We present a general formulation of special relativistic magnetohydrodynamics and derive exact radially self-similar solutions for axisymmetric outflows from strongly magnetized, rotating compact objects. We generalize previous work by including thermal effects and analyze in detail the various forces that guide, accelerate, and collimate the flow. We demonstrate that, under the assumptions of a quasi-steady poloidal magnetic field and of a highly relativistic poloidal velocity, the equations become effectively time independent and the motion can be described as a frozen pulse. We concentrate on trans-Alfvénic solutions and consider outflows that are super-Alfvénic throughout in the companion paper. Our results are applicable to relativistic jets in gamma-ray burst (GRB) sources, active galactic nuclei, and microquasars, but our discussion focuses on GRBs. We envision the outflows in this case to initially consist of a hot and optically thick mixture of baryons, electron-positron pairs, and photons. We show that the flow is at first accelerated thermally but that the bulk of the acceleration is magnetic, with the asymptotic Lorentz factor corresponding to a rough equipartition between the Poynting and kinetic energy fluxes (i.e., ~50% of the injected total energy is converted into baryonic kinetic energy). The electromagnetic forces also strongly collimate the flow, giving rise to an asymptotically cylindrical structure.

We present exact radially self-similar solutions of special relativistic magnetohydrodynamics representing ``hot'' super-Alfvénic outflows from strongly magnetized, rotating compact objects. We argue that such outflows can plausibly arise in gamma-ray burst (GRB) sources and demonstrate that, just as in the case of the trans-Alfvénic flows considered in the companion paper, they can attain Lorentz factors that correspond to a rough equipartition between the Poynting and kinetic energy fluxes and become cylindrically collimated on scales compatible with GRB observations. As in the trans-Alfvénic case, the initial acceleration is thermal, but, in contrast to the solutions presented in the companion paper, part of the enthalpy flux is transformed into Poynting flux during this phase. The subsequent, magnetically dominated acceleration can be significantly less rapid than in trans-Alfvénic flows.

There are observational indications that relativistic outflows in AGNs are accelerated over distances that far exceed the scale of the central engine. Examples include the radio galaxy NGC 6251, where knots in the radio jets were inferred to accelerate from ~0.13c at a distance of ~0.53 pc from the galactic nucleus to ~0.42c at r=1.0 pc, and the quasar 3C 345, where the Lorentz factor of the radio knot C7 was deduced to increase from ~5 to >10 as it moved from r=3 pc to r=20 pc. It is argued, using exact semianalytic solutions of the relativistic MHD equations, that this behavior is a signature of magnetic acceleration. The same basic driving mechanism may apply to the relativistic jets in AGNs, gamma-ray burst sources, and microquasars.

This study describes the adaptation of the State-Trait Anxiety Inventory for Children (STAIC; Spielberger, Edwards, Lushene, Montuori, & Platzek, 1973) to the Greek population. It was hypothesized that the STAIC would be able to measure children’s state-trait anxiety levels. In the initial phase, a sample of 100 children, aged 9-12 years, was used in order to shape the final form of the inventory. In the final phase, two different samples (N= 875), aged 9-12 years, were used to test the validity and reliability of the inventory, using exploratory (Sample A; n = 425) and confirmatory (Sample B; n = 450) factor analyses. The results indicated that both scales possessed an acceptable internal consistency and, reliability. The factor analysis in the total of the items indicated three factors, that is "absence of state anxiety," "presence of state anxiety," and "trait anxiety." Also, confirmatory factor analysis (AMOS; Arbuckle, 1997) verified three factors. It is therefore concluded that the scales have a multifactorial structure and can be used among the Greek population to examine children’s state and trait anxiety levels.

BACKGROUND: The development of large-scale gene expression profiling technologies is rapidly changing the norms of biological investigation. But the rapid pace of change itself presents challenges. Commercial microarrays are regularly modified to incorporate new genes and improved target sequences. Although the ability to compare datasets across generations is crucial for any long-term research project, to date no means to allow such comparisons have been developed. In this study the reproducibility of gene expression levels across two generations of Affymetrix GeneChips (HuGeneFL and HG-U95A) was measured. RESULTS: Correlation coefficients were computed for gene expression values across chip generations based on different measures of similarity. Comparing the absolute calls assigned to the individual probe sets across the generations found them to be largely unchanged. CONCLUSION: We show that experimental replicates are highly reproducible, but that reproducibility across generations depends on the degree of similarity of the probe sets and the expression level of the corresponding transcript.

Purpose: The objective of this study was to compare the uptake changes of Tc-99m 2-methoxy isobutyl isonitrile (MIBI) and Tc-99m pentavalent dimercaptosuccinic acid (V-DMSA) in multiple myeloma (MM) lesions in response to high-dose chemotherapy (HDC). Materials and Methods: The authors compared Tc-99m MIBI and Tc-99m V-DMSA scans before and after HDC in a patient with focal MM lesions without amyloidosis who had received previous standard chemotherapy as well. Results: HDC had the effect of eliminating all Tc-99m MIBI uptake in the lesions. Tc-99m V-DMSA uptake was increased in lesions presenting significant initial Tc-99m MIBI uptake. In 1 particular lesion that demonstrated this phenomenon, magnetic resonance showed necrosis of the area of MM. Conclusion: The authors consider that the effect of increasing Tc-99m V-DMSA uptake in the absence of an increase in viable plasma cells possibly reflects the treatment-generated inflammatory and fibrotic changes and not necessarily viable tumor tissue. Exclusive focal Tc-99m V-DMSA uptake in this clinical setting could be considered as a sign of effectively treated lesions and not a sign of deterioration.

OBJECTIVE: To identify risk factors for fever among patients treated in a neurologic intensive care unit (NICU). METHODS: The authors prospectively studied the frequency and causes of fever, defined as a patient's first temperature > or =101 degrees F (38.3 degrees C), among 387 patients consecutively admitted to their NICU. After identifying risk factors for 1) any fever, 2) infectious fever, and 3) unexplained fever using logistic regression, they calculated disease-specific adjusted odds ratios for developing these types of fever among 12 diagnostic groups. RESULTS: Fever occurred in 23% (87/387) of patients. Fifty-two percent of fevers were explained by infection (predominantly pneumonia or bronchitis), and 28% were unexplained despite a complete diagnostic evaluation. NICU length of stay was a risk factor for all three types of fever (all p < 0.004); other risk factors included depressed level of consciousness for any fever (p = 0.005) and infectious fever (p = 0.048), endotracheal intubation for infectious fever (p = 0.01), and intraventricular catheterization for unexplained fever (p = 0.004). Subarachnoid hemorrhage increased the risk of both infectious and unexplained fever, even after adjusting for these risk factors (p = 0.006). CONCLUSION: Fever occurs in nearly 25% of NICU patients, and is associated with increased length of stay and depressed level of consciousness. Endotracheal intubation is a risk factor for infectious fever, whereas intraventricular catheterization is a risk factor for unexplained fever, which suggests a role for ventricular hemorrhage in the pathogenesis of "central" fever. Subarachnoid hemorrhage increases the risk of developing fever of all types.

Rituximab, a chimeric monoclonal antibody, produces response rates of up to 73% in patients with previously untreated indolent non-Hodgkin's lymphoma (NHL), and has high activity when combined with chemotherapy. The purpose of this phase II study was to determine the efficacy and safety of rituximab plus cyclophosphamide, mitoxantrone, vincristine and prednisone (CNOP) chemotherapy in patients with indolent NHL. In all, 42 patients (median age 67 years) with previously untreated follicular, marginal zone or small lymphocytic/lymphoplasmacytic NHL received six infusions of rituximab (375 mg/m2) in combination with six cycles of CNOP. The overall response rate was 90% comprising 30 complete (71%) and eight partial (19%) responses. Although patients with marginal zone lymphoma or International Prognostic Index (IPI) score 3 had lower complete response rates, no significant difference in overall response rate was observed between the histological groups (P = 0.24) or between patients stratified according to IPI score (P>0.05). Median overall survival, time-to-progression and response duration had not been reached after a median 19.5-month follow-up. In all, 31 patients (74%) are currently free from progression and 38 (90%) remain alive. Treatment was well tolerated. One patient (2% experienced grade 3/4 infusion-related toxicity; 13 (31%) grade 3/4 leukopenia and 18 (43%) grade 3/4 neutropenia. Infection was observed in nine patients: eight (19%) grade 1/2 and one (2.4%) grade 3. This study demonstrates that combining rituximab with CNOP achieves high remission rates without significant additional toxicity in patients with previously untreated indolent NHL. Further follow-up will determine response duration and survival.

The aim of this paper is to discuss the concept of health tourism product as a competitive tourism product with a focus on Ikaria Island, Greece. The diversification of the health tourism product is explored and the study identifies key components for a successful development of a spa resort. The paper also examines the prospects for the thermal/mineral springs of Ikaria Island, taking account of the climatic and bioclimatic regimes of the area. The study concludes that there are prospects for future development if the spa product is diversified. This, in combination with the good climatic conditions of the area, can be a starting point for providing services in order to satisfy potential clients. Β© 2003 anatolia Printed in Turkey. All rights reserved.

The present review focuses and comments on the increasing body of evidence correlating respiratory viral infections with asthma onset and exacerbations.|Recent data suggest multiple and some time contrasting roles for viral infection in the origin of asthma. These data also indicate that the immune status of the host, including atopy, may interactively contribute to this process, conferring susceptibility or even resistance to the development of asthma in virus-infected individuals. In the presence of asthma, the role of viral infection in triggering exacerbations is clearly established. Chemokine and cytokine responses of the respiratory epithelium, a biased type 1/type 2 cytokine balance, defective costimulation, as well as abnormal neural control have been suggested as possible mechanisms. The importance of concurrent or synergistic effects of allergen exposure is currently under scrutiny.|Viruses may initiate and certainly exacerbate asthma. Mild repeated infections early in life could also stimulate type 1 immune responses conferring protection from atopy and asthma. The host's immune status, the type of viral infection and the timing of exposure to various environmental stimuli are probably the key factors in this process. Mechanistic insights deduced from recent work should allow for the development of intervening strategies in the near future.

Background: After birth, apoptosis rates might slow down, compared to those in utero. Thus, factors, attenuating the apoptotic process, like the soluble forms of Fas/FasL system, may increase. Aim - study design: Soluble Fas (sFas) and soluble Fas ligand (sFasL) concentrations were measured in maternal serum (MS), umbilical cord (UC) and neonatal serum in the first (1N) and fifth (5N) days after birth in order to evaluate the alterations of these molecules during the early neonatal period. Subjects and methods: Soluble molecules were estimated in 35 healthy, appropriate for gestational age, full-term neonates, their mothers and in 25 healthy, nonpregnant women, age-matched to the mothers (controls), using enzyme immunoassays. Results: sFas concentrations in MS (p<0.01), UC (p<0.0001), 1N (p<0.0003) and 5N (p<0.02) were lower than those in controls. Neonatal sFas concentrations showed a significant increase from UC to 5N (p<0.001). In contrast, sFasL concentrations were significantly elevated in all neonatal samples (UC, 1N and 5N) compared to those in MS and controls (p<0.0001), showing also a significant elevation from UC to 5N (p<0.0001). Conclusion: Our results demonstrate increasing serum concentrations of the soluble molecules sFas and sFasL during the first days after birth, indicating possibly a gradual decrease of apoptosis in early neonatal life. © 2003 Elsevier Ireland Ltd. All rights reserved.

The paper brings together recent work in English for specific purposes/languages for specific purposes (ESP/LSP) and adult education and puts forward an integrative model for ESP curriculum design. It outlines a set of characteristics that identify the ESP learner within the general adult learning framework. Taking current theories on the adult learner profile as a starting point, it then focuses on a model that associates adult education principles with effective ESP learning. This model has two sides. One side requires the adult learner's ESP teacher to come to terms with adulthood-oriented considerations (i.e. issues unique to adult learning), such as ‘mess-management’, motivation and adult learning cycles. The other side involves both a number of ELT-methodology-specific communicative strategies that are indispensable in the ESP class, such as self-directed learning techniques, as well as enhancing the role of the ESP teacher as counsellor. Some implications for the construction of CALL programmes are discussed and the paper ends with the suggestion that all approaches to teaching learners in the ESP framework can benefit from the successful handling of both aspects of the earlier model.

We present ab initio calculations for spin injection in Fe-ZnSe and Fe-GaAs(001) systems, with and without detection by a second Fe lead. We consider the case of hot injection, as well as the presence of a tunneling barrier at the interface. Our calculations are valid in the ballistic regime. We find that these systems can be very efficient spin filters, leading to current spin polarizations and magnetoresistance ratios very close to the ideal 100%.

We calculate the current spin polarization and the interface resistance of Fe/GaAs and Fe/ZnSe (001) spin injection junctions from first principles, including also the possibility of a Schottky barrier. From our results of interface resistance we estimate the barrier thickness needed for efficient spin injection if the process is nonballistic.

Stenotrophomonas maltophilia is rarely implicated in clinical infections but it constitutes a significant nosocomial pathogen, especially in immunocompromised patients. This report describes the first case of a generalised infection caused by S. maltophilia that included bacteremia, wound and respiratory tract infection in a patient suffering from burns. Given the emergence of S. maltophilia nosocomial infections, especially in patients with burns, isolation of the bacterium from blood cultures should prompt the commencement of adequate antibiotic treatment.

Myxopapillary ependymomas (MPEs) are low-grade neuroepithelial tumors typically occurring in the conus-cauda equina-filum terminale region. Limited molecular and cytogenetic analysis of MPEs has not demonstrated consistent abnormalities. In an attempt to clarify the chromosomal status of these tumors and identify commonly aberrant regions in the genome we have combined 3 molecular/cyto/genetic methods to study 17 MPEs. Comparative genomic hybridization of 7/17 tumors identified concurrent gain on chromosomes 9 and 18 as the most frequent finding. The majority of the 17 tumors were also studied using microsatellite analysis with marker spanning the whole chromosomes 9 and 18 and interphase-FISH with centromeric probes for both chromosomes. Our combined results were consistent with concurrent gain in both chromosomes 9 and 18 in 11/17 cases, gain of either chromosome 9 or 18 and imbalance in the other chromosome in 3/17 tumors and allelic imbalances of chromosomes 9 or 18 in 3/17 and 1/17 tumors, respectively. Other abnormalities observed included gain of chromosomes 3, 4, 7, 8, 11, 13, 17q, 20, and X and loss of chromosomes 10 and 22. Our findings represent some steps towards understanding the molecular mechanisms involved in the development of MPE.

Surface deformation and ferroelectric domain switching induced by a force microscope tip on a La-modified PbTiO3 thin film was studied. Polarization switching of the domains comprising the deformed region demonstrated the possibility of using scanning force microscopy (SFM) as a nanoscale tool for imaging phase transitions. It was found that if loading forces are higher than a threshold value, thin film characterization becomes invasive.

Background: Waldenstrom's macroglobulinemia (WM) is an unusual lymphoplasmacytoid lymphoma characterized by the presence of a serum monoclonal immunoglobulin M. Although several studies have evaluated possible prognostic factors of this disease, few have focused on the survival and prognosis of symptomatic patients after the initiation of treatment. Patients and methods: Our study included 122 previously untreated patients with a median age of 67 years who required systemic treatment. Multiple variables were analyzed for their prognostic value on survival after initiation of treatment using univariate and Cox regression multivariate analysis. Results: The median overall survival was 106 months. Pretreatment factors associated with shorter survival were age ≥65 years, splenomegaly, B-symptoms (weight loss, fever or night sweats), hemoglobin <10 g/dl, platelets <100 × 106/dl, albumin <3.5 g/dl and bone marrow lymphoplasmacytic infiltrate ≥50%. In the multivariate analysis, the two variables with independent prognostic value were age ≥65 years and hemoglobin <10 g/dl. Furthermore, we were able to divide our patients into three risk groups based on the presence of two, one or none of these two adverse prognostic factors. The median survival times in the high-, intermediate- and low-risk groups were 46 months, 107 months and 172 months, respectively (P <0.0001). Discussion: Our findings suggest that advanced age and anemia appear to be the two dominant prognostic factors for survival after initiation of treatment in patients with WM. These two readily available parameters can stratify the patients into three distinct subgroups and may help the selection of appropriate treatment.

Six stars out of a sample of ~2300 carbon stars in the Magellanic Clouds have been identified as having strong C2 bands but CN bands that are very weak or absent. It is argued that five of these are likely to be R Coronae Borealis (RCB) stars on the basis of their spectral characteristics and peculiar colours. Most are variables and the Large Magellanic Cloud (LMC) members have extreme radial velocities that are more like the planetary nebula population than the carbon stars. This sample consists of four LMC members (only one of them previously recognized as an RCB star), one Small Magellanic Cloud (SMC) member (the first RCB star reported in the SMC) and one foreground Galactic star.

The synthesis of optically pure long-chain 2-amino-alcohols and 1-O-dodecyl-2-deoxy-2-amino-sn-glycerol was carried out starting from l- or d-Boc-Ser(OBn)-ol by oxidation and consecutive Wittig reaction or etherification reaction. 2-Amino-oleyl alcohol was synthesized by reduction of the corresponding 2-amino-oleic acid. All the long chain amino-alcohols presented interesting inhibition of carrageenin-induced paw edema in rats (ED50 from 0.017 to 0.010 mmol/kg). The synthesis, anti-inflammatory and analgesic activity of long-chain 2-amino-alcohols is reported.

 This review article focuses on the synthesis and reactions of N,N-di-Boc glutamate and aspartate semialdehydes as well as related aldehydes. These building blocks are prepared according to various strategies from glutamic and aspartic acids and find interesting synthetic applications. In the first part, the methods for the synthesis of N,N-di-Boc-amino aldehydes are summarized. The applications of these chiral synthons for the synthesis of unnatural amino acids and other bioactive compounds are discussed in the second section.

The systematics of the first 2+ state g factors in the mass 80 region are investigated in terms of an IBM-II analysis, a pairing-corrected geometrical model, and a shell-model approach. Subshell closure effects at N = 38 and overall trends were examined using IBM-II. A large-space shell-model calculation was successful in describing the behavior for N=4 and N=50 nuclei, where single-particle features are prominent. A schematic truncated-space calculation was applied to the lighter isotopes. The variations of the effective boson g factors are discussed in connection with the role of F-spin breaking, and comparisons are made between the mass 80 and mass 180 regions.

This paper explores the relationship of the perfect with time, in its grammatical expression both as tense and as aspect. While not denying that the perfect has other, non-temporal and non-aspectual uses, while in fact admitting that they are more wide-spread than its time-related uses, it argues that a relationship with time does exist; of the various time-related meanings associated with the perfect it is anteriority that turns out to be more “basic”, in the sense that all the other meanings of the perfect can be derived from it. The article has a strong historical bias: the basic meaning is assumed to have a historical precedence as well as a logical one. 

Recently completed phase II trials and retrospective analyses conducted outside the United States, primarily in Europe and Australia, have confirmed results of landmark US trials that established the efficacy of thalidomide in multiple myeloma. These trials evaluated thalidomide alone or in combination in patients with heavily pretreated relapsed/refractory multiple myeloma. Single-agent thalidomide induced objective responses in approximately one third of patients and prolonged survival by approximately 1 year. These trials also indicated a possible dose-response relationship of thalidomide and identified several poor prognostic factors, including advanced age, high lactose dehydrogenase level, low platelet count, and low hemoglobin level. The combination of thalidomide with dexamethasone increased overall response by approximately 20% and reduced the time to response compared with thalidomide alone. In addition, lower doses of thalidomide used in the combination may increase patient tolerability. Finally, thalidomide in combination with chemotherapy yields response rates of approximately 60%, with median survival times of approximately 18 months. Randomized trials are needed to confirm these results and further explore the role of thalidomide in these treatment settings. © 2003 Elsevier Inc. All rights reserved.

We look for the expected signature of an accretion disc by examining the properties of the Hα emission line versus viewing angle in a sample of 22 superluminal (SL) quasars. The Doppler factor δ, jet velocity γ and viewing angle θ towards the jet are derived from published radio and X-ray data. Most of the Hα spectra (14) have been observed at the United Kingdom Infrared Telescope (UKIRT) and are reported here. About a quarter of the SL objects have weak or absent Hα emission lines, with small equivalent widths (EW). These have high optical polarization, radio core dominance and Doppler factor, and most of them have high apparent SL velocity and low viewing angles. Therefore these weak-EW objects almost certainly have relativistically beamed optical continua. The strong-EW objects also show a clear beaming effect, but a much weaker one, with line EW varying by only a factor of 3 while radio core dominance varies by a factor of several hundred. The correlation of EW with θ is quantitatively in good agreement with the prediction of a flat accretion disc with limb darkening. The weak- and strong-EW sources also show an anticorrelation of line velocity width with the various beaming indicators. Again, the correlation with the derived viewing angle θ shows a quantitative agreement with the effect expected for an axisymmetric structure with velocity dominated by rotation. The line emission cannot come from the surface of the disc, or the line beaming would cancel the continuum beaming. However, it could come from an axisymmetric system of clouds corotating with the accretion disc.

The purpose of this prospective phase II trial was to investigate the safety and efficacy of a modified baseline BEACOPP (bleomycin, etoposide, adriamycin, cyclophosphamide, vincristine, procarbazine, and prednisone) regimen in the treatment of intermediate and advanced stage Hodgkin's disease (HD). From October 1997 to November 2001, 51 consecutive, previously untreated patients with stage IIA (bulky), IIB, III, and IV disease were treated with a modified baseline BEACOPP regimen with the etoposide administered i.v. on day 1 and orally at a dose of 100 mg/m2, on days 2 and 3. Each patient was scheduled to receive eight courses of BEACOPP with consolidation radiotherapy to bulky (≤5 cm) or residual disease. There were 25 males and 26 females with a median age of 32 yr (16-65 yr); 80.3% of the patients had nodular sclerosis HD, 41% had bulky disease (≥5 cm), 10 were in stage IIA (bulky ≥10 cm), 15 in stage IIB, 19 in stage III, and seven in stage IV. Thirty-seven patients (72.5%) achieved a complete response and 17.6% partial response. No significant difference in overall response rate was observed between patients with: (i) 0-2 vs. ≥3 negative prognostic factors, (ii) in stage II vs. stages III/IV, LDH level, and bulky disease. With a median follow up period of 39.5 months, actuarial 3-yr survival rate is 82% and time to progression rate 72.5%. Treatment with this combination was well tolerated. Grades 3 and 4 leukopenia and neutropenia occured in 26% and 28% of the patients, respectively, whereas in 16.3% of the patients infection was observed. Support with granulocyte colony-stimulating factor was given to 59% of the patients. No case of secondary MDS/leukemia has been observed. The results of the present study demonstrate that the modified baseline BEACOPP regimen with radiotherapy used in our patients was well tolerated and effective therapy for intermediate and advanced stage HD. Further follow up time is required to evaluate long-term toxicity.

Background: The efficacy and toxicity of gemcitabine (GEM) and irinotecan (CPT-11) is evaluated in previously untreated patients with inoperable or metastatic pancreatic cancer. Patients and methods: From January 1999 to July 2001, 60 patients with pancreatic cancer (85% stage IV) were enrolled in a two-step extended phase II trial. Patients were treated with gemcitabine (1000 mg/m2 on days 1 and 8) and CPT-11 (300 mg/m2 on day 8) in cycles of 3 weeks. No prophylactic use of recombinant human granulocyte colony-stimulating factor (rhG-CSF) was initially planned. Results: In an intention-to-treat analysis one (1.7%) complete and 14 (23.3%) partial responses were achieved [objective response rate (ORR) 24.7%; 95% confidence interval 14.04% to 35.96%]. Twenty-two (36.7%) and 23 (38.3%) patients had stable and progressive disease, respectively. The median duration of response was 5 months, the median time to tumor progression (TTP) was 7 months and the median overall survival 7 months. One-year survival was 22.5%. Pain improvement and asthenia during treatment were observed in 45% and 43% of patients, respectively; weight gain occurred in 19.5% of patients. Grade 3 anemia occurred in three (5%) patients who required transfusion of six packed red blood cell (RBC) units. Ten (16.7%) additional patients with grade 2 anemia were treated with recombinant erythropoietin. Grade 3 thrombocytopenia occurred in seven (11.7%) patients and grades 3 and 4 neutropenia in 27 (45%). Ten patients developed febrile neutropenia, two of whom died due to sepsis. Prophylactic use of rhG-CSF was eventually required in 93 (28.3%) of 329 administered cycles. Other toxicities were mild. Conclusions: The combination of gemcitabine and irinotecan is an active chemotherapy regimen against pancreatic cancer with a 25% ORR. Toxicity was acceptable for the great majority of patients but with a high percentage of hematopoietic growth factor administration.

Purpose: In 1999, investigators reported promising results of a phase II study of thalidomide in patients with resistant multiple myeloma (MM). Since then, various trials of thalidomide alone and in combination with other agents have been tested in patients with resistant and, more recently, untreated MM. In addition, preliminary results of phase I studies of the immunomodulatory derivatives (IMiDs) of thalidomide have been recently reported. Design: We reviewed and report the results of clinical trials of thalidomide and the IMiDs, as well as the pharmacology, mechanism of action, and toxicity of these agents. Results: Thalidomide has demonstrated significant activity in both resistant and previously untreated multiple myeloma. Combination therapy with dexamethasone increases response rate, even in patients previously resistant to both drugs given as single agents. More recent studies of thalidomide with dexamethasone in previously untreated patients are highly encouraging. The addition of chemotherapy to thalidomide and dexamethasone may further increase response rates, but its effect on patient survival has not been clarified. Preliminary results of trials of IMiD-3 indicate that this agent is active in resistant myeloma and has a toxicity profile different from that of thalidomide. Conclusion: Many studies have confirmed the activity of thalidomide in MM, as well as an improved response with dexamethasone. Newer thalidomide derivatives with reduced toxicity (neuropathy, teratogenicity) are also promising. Thalidomide with dexamethasone may now represent the treatment of choice for previously untreated patients. Further studies with these and other novel agents early in the course of myeloma may improve complete remission rates and frequency of long-term control. © 2003 by American Society of Clinical Oncology.

To evaluate the activity of thalidomide in Waldenstrom's macroglobulinemia (WM), 20 patients were treated on a dose schedule that escalated from 200 mg/d to 600 mg/d. On an intention-to-treat basis, five (25%) patients achieved a partial response, which was noted within 3 months of treatment. Adverse effects were common and prevented dose escalation of thalidomide in 75% of patients and led to premature discontinuation of treatment in 35%. We subsequently evaluated the oral combination of clarithromycin (500 mg twice per day), low-dose thalidomide (200 mg once daily), and dexamethasone (40 mg once per week). Our preliminary analysis on 12 previously treated patients indicate activity of this regimen in WM: three patients achieved a partial response and two patients demonstrated monoclonal protein reduction of greater than 25%. This combination was associated with a variety of side effects due not only to thalidomide, but also to corticosteroids and to clarithromycin. Our preliminary data indicate that this combination may be a useful salvage regimen for some patients with heavily pretreated macroglobulinemia. © 2003 Elsevier Inc. All rights reserved.

Fludarabine is an active agent for the treatment of Waldenstrom's macroglobulinemia (WM) and its combination with cyclophosphamide has been effective in many patients with low-grade lymphoma and chronic lymphocytic leukemia. Based on these data, we administered the combination of fludarabine (25 mg/m2 IV day 1-3) and cyclophosphamide (250 mg/m2 IV day 1 - 3,) to 11 patients with WM. Most patients had features indicating poor prognosis including median age of 73 years (range 60-84 years), hemoglobin <100g/l in 73%, B2-microglobulin >3mg/l in 64%, symptomatic hyperviscosity in 55% of patients. Only 2 patients were previously untreated, 7 were primary refractory and 2 were relapsing on treatment. The fludarabine-cyclophosphamide combination (FC) was administered every 4 weeks for a total of four courses. Partial response, defined by at least 50% reduction of serum monoclonal protein and of tumor infiltrate at all involved sites was documented in 6 patients (55%) (The median time to response was 4 months). Responding patients demonstrated resolution of disease-related symptoms and correction of anemia. Median time to progression for all patients was 24 months. With a mean follow-up of 28 months, two of six responding patients have progressed so far. The probability of 2-year survival is 70%. This regimen was relatively well tolerated. Complications included neutropenia grade 3 or 4 in 3 patients and thrombocytopenia grade 3 or 4 in 2 patients. There were five infectious episodes including two episodes of neutropenic fever. We conclude that the FC combination appears to be active in patients with WM most of whom were resistant to treatment and had poor prognostic factors. The addition of rituximab to FC requires further investigation.

O-tert-Butyldimethylsilylimidazolyl aminals are N,O-acetals that form readily from aldehydes, and although they function as aldehyde stabilizing and protecting groups under various conditions, we report here that they react with organolithium reagents similarly to the parent aldehydes. The mechanism involves the intermediate formation of a 2-imidazolyl anion as is exemplified by the isolation of 2-TBDMS-imidazole. Substitution of the imidazolyl moiety at the 2-position renders these aldehyde derivatives stable to organolithium reagents, thus allowing for the tuning of their reactivity.

O-tert-Butyldimethylsilylimidazolyl aminals are N,O-acetals that form readily from aldehydes, and although they function as aldehyde stabilizing and protecting groups under various conditions, we report here that they react with organolithium reagents similarly to the parent aldehydes. The mechanism involves the intermediate formation of a 2-imidazolyl anion as is exemplified by the isolation of 2-TBDMS-imidazole. Substitution of the imidazolyl moiety at the 2-position renders these aldehyde derivatives stable to organolithium reagents, thus allowing for the tuning of their reactivity.

Background: We investigated the efficacy and safety of 2 cycles of adjuvant chemotherapy with carboplatin, etoposide and bleomycin (CEB 90) in patients with high-risk clinical stage I or stage IM non-seminomatous germ cell tumours (NSGCT). Patients and Methods: A total of 52 consecutive patients (22 patients with high-risk histological features [vascular invasion, presence of embryonal carcinoma, absence of yolk sac tumour] and 30 with tumour marker activity post-orchidectomy-stage IM) were entered into this prospective study. Chemotherapy consisted of carboplatin 400mg/m 2 or AUC 5 (day 1), etoposide 165mg/m2 (days 1-3) and bleomycin 30 mg (days 1, 8, 15). Chemotherapy was repeated every 3 weeks. Results: During a median follow-up of 112 months (range, 10 to 174 months), two patients with stage IM relapsed. These cases had a disseminated, marker-positive germ cell tumour (GCT), extensively involving both liver and lungs in the first case and para-aortic lymph nodes and lung in the second one; both patients died of the tumour after a number of salvage chemotherapy (including high-dose therapy) regimens. Fifty patients (96%) are alive and disease-free. Two cycles of CEB90 were well tolerated and the only side-effects were myelotoxicity and alopecia. Conclusion: Despite the general consensus that ciplatin-based chemotherapy is superior to carboplatin-containing regimens in testicular cancer, 2 cycles of CEB 90 may be an equally effective treatment option as adjuvant therapy for high-risk clinical stage I and IM patients.

Living coccolithophores were collected from eight stations along a transect in the gulf of Korthi (southeastern Andros island, Aegean Sea, Eastern Mediterranean) in August 2001. Samples were collected from 0–120 m water depth to determine the cell density, the species composition and the biogeographical (spatial and vertical) distribution of the coccolithophore biocommunities in coastal marine ecosystems. The studies revealed an impressive heterococcolith–holococcolith combination coccosphere (SEM micrograph) involving the species Algirosphaera robusta and Sphaerocalyptra quadridentata. In addition, a second association was observed by light microscopy. This discovery verifies the suggestions of Kamptner (1941) and provides strong proof on the assignment of these two ‘species’ in a common life cycle, increasing significantly our knowledge of life-cycle pairings ecology.

Living coccolithophores were collected from eight stations along a transect in the gulf of Korthi (southeastern Andros island, Aegean Sea, Eastern Mediterranean) in August 2001. Samples were collected from 0–120 m water depth to determine the cell density, the species composition and the biogeographical (spatial and vertical) distribution of the coccolithophore biocommunities in coastal marine ecosystems. The studies revealed an impressive heterococcolith–holococcolith combination coccosphere (SEM micrograph) involving the species Algirosphaera robusta and Sphaerocalyptra quadridentata. In addition, a second association was observed by light microscopy. This discovery verifies the suggestions of Kamptner (1941) and provides strong proof on the assignment of these two ‘species’ in a common life cycle, increasing significantly our knowledge of life-cycle pairings ecology.

Most of the carbon stars observed with 2dF were selected from the newly completed catalogue of 7760 carbon stars by (Kontizas et al., 2001, Cat. , hereafter KDMK01). (1 data file).

The horizontal and vertical distributions of volatile organic compounds (VOCs) and ozone (O3) concentrations within the lower troposphere over the greater Athens area. Greece, under sea-breeze conditions were studied. Furthermore, an attempt was made to explain the dynamic and chemical mechanisms responsible for the formation of these distributions. Measurements were collected using a specially instrumented Falcon 20-E5 research aircraft, ground-based meteorological instrumentation, and a network of air quality monitoring stations within the context of the Scientific Training and Access to Aircraft for Atmospheric Research Throughout Europe (STAAARTE) 1997 experimental campaign. Relatively high ozone values (55-100 ppbv) were identified within the first 300-400 m above ground, and significantly reduced values were found over the depth of the atmospheric boundary layer. High values of VOC concentrations [150-350 ppbCarbon (C)] were observed near the ground as well as within the first 300 400 m above ground. At higher altitudes, of 1400-1600 m, VOC concentrations remained relatively high (100-200 ppbC). It was demonstrated that the sea-breeze circulation plays a major role in the formation of the above-mentioned concentration levels and that chemical transformations explain specific characteristics.

We report systematic first-principles calculations for ordered zinc-blende compounds of the transition metal elements V, Cr, and Mn with the sp elements N, P, As, Sb, S, Se, and Te, motivated by a recent fabrication of zinc-blende CrAs, CrSb, and MnAs. They show a ferromagnetic half-metallic behavior for a wide range of lattice constants. We discuss the origin and trends of half-metallicity, present the calculated equilibrium lattice constants, and examine the half-metallic behavior of their transition element terminated (001) surfaces.

Η έρευνα εστιάστηκε στην καταγραφή: -των αθλητικών συνηθειών των μαθητών Δημοτικού-Γυμνασίου-Λυκείου, -των απόψεών τους για την επάρκεια της απαιτούμενης αθλητικής υποδομής στην περιοχή μόνιμης διαμονής τους και στο σχολικό τους χώρο, -της κατανομής του ελεύθερου χρόνου για αθλητικές δραστηριότητες,  - των εκφρασμένων αντιλήψεών τους για το μάθημα της Φυσικής Αγωγής και για τη σχέση σχολείου - αθλητικών δραστηριοτήτων.

This study discusses and evaluates the views of Donald W. Winnicott (1896-1971), a distinguished British pediatrician and psychoanalyst, which explicitly or implicitly are related to loneliness and solitude. Α theoretical approach to the developmental origins of loneliness is as yet to be formulated in the field of developmental psychology. Notions such as the capacity to be alone, the good-enough mother, holding and mirroring, true and false self, childhood psychotic isolation, illusion and disillusionment, transitional object and transitional phenomenon, potential space, playing and creative activity, the non-communicating core self, the “journey” from absolute dependence towards independence, etc., are discussed in the light of their implications for the understanding of loneliness and solitude experiences. The exploration and interpretation of these notions show their usefulness in the construction of a developmental model of loneliness and solitude as well as their fruitfulness for further empirical research on this topic.

Ιn diesem Artikel die Besonderheiten des Zweitspracherwerbes hervorgehoben und auf die Bedeutung einer entsprechenden Ausbildung jener Lehrer hingewiesen, die Schüler unterrichten, für die das Neugriechische eine erste, eine zweite oder sogar eine dritte Sozialisationssprache darstellt.

Η εργασία συνιστά μια συμβολή στην πολιτισμική αξιολόγηση των αρχαίων Ολυμπιακών Αγώνων, καθώς είναι αδιαμφισβήτητος ο πολυσήμαντος ρόλος και η καταλυτική παρουσία των αγώνων στον δεδομένο ιστορικό χρόνο. Η πραγματοποίηση των αγώνων σε ένα ‘κέντρο’ αποτελεί κοινό χαρακτηριστικό της αξιολογίας των Ολυμπίων και των άλλων μεγάλων αγώνων της αρχαιότητας, καθώς αυτοί τελούνται σε τόπους οι οποίοι αποτελούν ισχυρά λατρευτικά κέντρα, στα οποία με ενδιάμεσο την θρησκευτική λατρεία η ομάδα έρχεται σε συνάφεια με τους κοινούς θεούς. Η συνεύρεση της ομάδας στα κέντρα αυτά διαμορφώνει το πρωτογενές υλικό αυτού που θ’ αποκαλεστεί αργότερα ως συνείδηση εθνική, καθώς οι ‘εθνικές’ τελετές συνιστούν επικοινωνίες κοινοτήτων και συνύπαρξη πληθυσμών, οι οποίες κατοχυρώνουν ταυτόχρονα και μια πολιτική διαλεκτική, που με τον περίφημο θεσμό της εκεχειρίας αναμφισβήτητα καθορίζει και τον πολιτικό χαρακτήρα των Ολυμπιακών Αγώνων. Η κοινή ειρηνική και ψυχαγωγική συνύπαρξη, χωρίς να υποτιμάται και ο οικονομικός χαρακτήρας της γιορτής, προσδιορίζουν ένα πλαίσιο πολυφωνίας ικανό να δημιουργήσει και να προβάλλει υψηλές φιλοσοφικές και ανθρωπιστικές ιδέες. Ο εναγκαλισμός των αγώνων υπό της τέχνης έρχεται να εκφράσει καλλιτεχνικές και πολιτιστικές αξίες, ολοκληρώνοντας τελικά μέσω της τέχνης την αποτύπωση του κλασικού αθλητή και συνδέοντάς την με την ηθική τελεολογία.

Social Representations of School-Age Children on Drugs Eleni Zymvrakaki, Kyriakos Athanasiou Summary The origins of this work go back to a series of epidemiological surveys conducted over the last twenty years and prove the ever-increasing use of illegal substances among the entire population of Greece (Kokkevi K.a., 1983, Marselos and Frangidis, 1985, Madianou et al., 1987, Dardavesis, 1993, Kokkevi and Stefanis, 1994, Madiano; et al., 1995, Gougouskidis, 2001, Charila and Kalantzi-Azizi, 2001, EKTEPN, 2002a, EKTEPN, 2002b). It is common knowledge that the use of illegal substances is reduced to one of the most important social problems. In Greece too, the problem is exacerbated, as there is an increase in the frequency of deaths from heroin use in the mainly young population, while at the same time observing... Οι απαρχές της εργασίας αυτής ανάγονται σε μια σειρά επιδημιολογικών ερευνών που διεξήχθησαν την τελευταία εικοσαετία και αποδεικνύουν την ολοένα αυξανόμενη χρήση παράνομων ουσιών στο σύνολο του πληθυσμού της Ελλάδας(Κοκκέβη Κ.α., 1983, Μαρσέλος και Φραγκίδης, 1985, Μαδιανού κ.α., 1987, Δαρδαβέσης, 1993, Κοκκέβη και Στεφανής, 1994, Μαδιανό; Κ.α., 1995, Γκουγκουσκίδης, 2001, Χαρίλα και Καλαντζή-Αζίζι, 2001, ΕΚΤΕΠΝ, 2002α, ΕΚΤΕΠΝ, 2002β).Είναι κοινός τόπος ότι η χρήση παράνομων ουσιών ανάγεται σε ένα σε ένα από σημαντικότερα κοινωνικά προβλήματα. Και στην Ελλάδα το πρόβλημα οξύνεται, καθώς παρατηρείται αύξηση της συχνότητας θανάτων από τη χρήση ηρωίνης στο νεανικό κυρίως πληθυσμό, ενώ ταυτόχρονα παρατηρεί τω...

http://www.dardanosnet.gr/book_details.php?id=1041Κωδικός καταλόγου: 402089 ISBN: 978-960-402-089-7 1η ανατύπωση Απρίλιος 2005 (1η έκδοση, Μάιος 2003) 14 x 21 σελ. 451 Κωνσταντίνα Γογγάκη Αντιλήψεις των αρχαίων Ελλήνων για τον Αθλητισμό (Οι) Εκδόσεις: Τυπωθήτω Περίληψη.  Ο αθλητισμός, αποτελώντας ένα τμήμα της κοινωνικής ζωής, επηρεάζει την κοινωνία και επηρεάζεται απ' αυτήν. Έτσι, ο κλασικός αθλητισμός, συνιστώντας μιαν έκφανση της εποχής της ακμής, αντανακλά μιαν από τις πιο δυναμικές πτυχές αυτής της περιόδου. Η σημασία του αθλητισμού, ο πολυσήμαντος ρόλος του, η αγωνιστική νίκη που αποτύπωνει το κλέος και το κύδος των ανδρών, η συγκίνηση του αθλητικού θεάματος, συνδέονται με μερικές από τις καλύτερες στιγμές του δημιουργικού ανθρώπινου πνεύματος. Εκτός, όμως, από την θετική υπάρχει και η αρνητική όψη του αρχαίου αθλητισμού, η οποία επικρίθηκε και καυτηριάστηκε, χωρίς, ωστόσο, να επηρεάσει την εκ μέρους της αρχαίας κοινωνίας αποδοχή του αθλητικού γεγονότος, και η οποία αρνητική όψη επιβεβαιώνει τελικά, εκ του αντιθέτου, τη διαχρονική αξία του μέτρου και της ψυχικής και σωματικής εναρμόνισης. Αυτήν την διττή προσέγγιση, των φωτεινών και των σκοτεινών πλευρών του αρχαίου αθλητισμού, επιχειρεί η παρούσα εργασία, λαμβάνοντας υπ' όψιν τις πηγές της κλασικής παράδοσης. Με τον τρόπο αυτό ξετυλίγεται ένα πλούσιο υλικό, που αποκαλύπτει τις αντιλήψεις των αρχαίων Ελλήνων για τον αθλητισμό, από τον Όμηρο, τον Τυρταίο, τον Πίνδαρο και τον Πλάτωνα, έως τον Γαληνό, τον Φιλόστρατο, τον Παυσανία και τον Λιβάνιο, ενώ, παράλληλα, γίνεται αναφορά σε ορισμένους Ρωμαίους συγγραφείς. Από τη γενική αξιολόγηση του αρχαίου αθλητισμού και τις αντιστοιχίες του στο σύγχρονο αθλητικό γίγνεσθαι, εντέλει αποδεικνύεται πως ο λόγος περί ηθικής και μέτρου στον αθλητισμό είναι όχι μόνον διαχρονικός, αλλά, σήμερα, άκρως αναγκαίος και επίκαιρος. Περιεχόμενα.  Πρόλογος Ανδρέα Μάνου || Εισαγωγή || Οι αθλητικοί αγώνες στην Ιλιάδα και την Οδύσσεια: Μια συγκριτική θεώρηση || Η αγωνιστική νίκη ως αξία στις πινδαρικές ωδές || Η σημασία της νίκης μέσα από τον τύπο του ηττημένου αθλητή κατά τον Πίνδαρο || Προσέγγιση των Πυθίων αγώνων δια της αγγελικής ρήσης στην "Ηλέκτρα" του Σοφοκλή || Η κατά Πλάτωνα "Περί Γυμναστικής" διδασκαλία || Το στεφάνι του νικητή των αγώνων και οι ηθικοί συμβολισμοί του || Το νόημα της ολυμπιακής νίκης στην κλασική αρχαιότητα || Η πολιτισμική αξία των αρχαίων ολυμπιακών αγώνων || Μορφές βίας στα αρχαία αθλήματα || Επικριτικοί λόγοι κατά του αρχαίου αθλητισμού || Γενική βιβλιογραφία || Ευρετήριο ονομάτων || Ευρετήριο εννοιών.

The aim of this study was to investigate school-age children's perceptions and experience of family-related loneliness, and of coping with it. The literature review showed that these dimensions have not been empirically investigated. This study is part of a larger research program that examined children's perceptions of loneliness and its causes, as well as coping with loneliness strategies. Individual interviews were conducted (the interview was constructed on the basis of two pilot studies) and the projective technique of oral story was used with 180 second, fourth and sixth graders. Also, 758 fifth and sixth graders were asked to write a story about loneliness. The samples were randomly chosen from schools in Athens and Piraeus. Children's responses indicating their personal, subjective views of family-related loneliness are discussed within mainly the psychoanalytic developmental framework, and their importance for the construction of a developmental model of loneliness experience in childhood is noted.

Το στεφάνι του νικητή των αγώνων υποδηλώνει την ύπαρξη παλαιών δοξασιών, που κατά την μακρινή πορεία του χρόνου έλαβαν άλλες μορφές ή απωθήθηκαν στο υποσυνείδητο της ανθρωπότητας. Η καταγωγή τους ανάγεται στο βαθύ παρελθόν, τότε που ο πρωτόγονος άνθρωπος ανέπτυσσε τις διάφορες λατρείες στην βάση οτι όλα τ’ άψυχα έχουν ψυχή, κι επομένως το δέντρο και συνεπώς το κλαδί έχουν και μπορούν να μεταδώσουν την θετική δύναμή τους. Οι διάφορες μαγικές και ανιμιστικές θεωρίες γρήγορα ενσωματώνονται στις αγροτικές τελετές που ως σκοπό είχαν την γονιμότητα και την ευφορία της γης. Με την επίδραση του ορθολογικού στοιχείου πάνω στο μαγικό και στο μεταφυσικό, οι δοξασίες αυτές μεταβάλλονται, προσδίδοντας στο στεφάνι και τα κλαδιά ορισμένων δέντρων, όπως η ελιά και η δάφνη, έναν χαρακτήρα ιερό. Έτσι στις ήδη υπάρχουσες δοξασίες κυριαρχούν οι θρησκευτικές αντιλήψεις, του εξαγνισμού και της κάθαρσης, ηθικές αξίες που μεταδίδονται μέσω του ιερού στεφανιού στον νικητή των αγώνων, ο οποίος με τον τρόπο αυτό καθαίρεται, αποκτώντας την ικανότητα επικοινωνίας με το θείον. Κατάλοιπα αυτών των αντιλήψεων επιβιώνουν σήμερα όχι μόνο στο στεφάνι του νικητή των αγώνων, αλλά και σ’ άλλα έθιμα, όπως στο στεφάνι του Μαγιού, στο στεφάνι του γάμου κ.λ.π.  

как письмо в редакцию,  Москва, 2003. (Αναδημοσίευση στην ΠΕΜΠΤΟΥΣΙΑ στις 23/7/2013 στα Ρωσικά) Η δημοσίευση περιλαμβάνει τις κυριότερες θέσεις της διδακτορικής διατριβής για την ηθική θεώρηση της υποβοηθούμενης αναπαραγωγής στο ιατρικό περιοδικό «Ιατρική Βοήθεια» στη ρωσική γλώσσα με τη μορφή γράμματος προς τον εκδότη του περιοδικού (Letter to Editor), στην οποία συνέδραμε ο Ρώσος νευροχειρούργος Boleslav Lichtermann. Η σύνταξη του Ρωσικού περιοδικού ζήτησε τη δημοσίευση των συμπερασμάτων της διατριβής μας για να προβληθούν τα ηθικά διλήμματα που προκύπτουν στις αναπαραγωγικές τεχνολογίες. 

Relative kinetic data were determined for the 5-endo-trig cyclization of radical 12 compared to hydrogen abstraction from (TMS) 3SiH in the temperature range of 344-430 K, which allows for the estimation of a rate constant of 2 × 10 4 s -1 at 298 K with an activation energy of ca. 9 kcal/mol for the cyclization process. The 5-endo-trig cyclization of a variety of radicals that afford five-membered nitrogen-containing heterocycles was addressed computationally at the UB3LYP/6-31G* level. The 5-endo vs 4-exo mode of cyclication and the effect of delocalization of the unpaired electron in the transition state were investigated. Because the ring formed during cyclization contains five sp 2 centers, electrocyclization via a pentadienyl-like resonance form was also considered. For comparison, similar calculations were performed for 4-penten-1-yl and related radicals. The factors that affect the activation energies of homolytic 5-endo-trig cyclization were determined. In the absence of steric or conformational effects, the endo cyclization to form the five-membered ring was strongly favored over exo cyclization to form the four-membered ring not only on thermodynamic grounds but also kinetically. When a substituent on the double bond was able to delocalize the unpaired electron in the transition state of the 4-exo path, the two modes of cyclization became kinetically comparable. These results have an important bearing on the generalization of the Baldwin-Beckwith rules, which classified the 5-endo-trig radical cyclization as a "disfavored" process.

Relative kinetic data were determined for the 5-endo-trig cyclization of radical 12 compared to hydrogen abstraction from (TMS)(3)SiH in the temperature range of 344-430 K, which allows for the estimation of a rate constant of 2 x 10(4) s(-1) at 298 K with an activation energy of ca. 9 kcal/mol for the cyclization process. The 5-endo-trig cyclization of a variety of radicals that afford five-membered nitrogen-containing heterocycles was addressed computationally at the UB3LYP/6-31G* level. The 5-endo vs 4-exo mode of cyclication and the effect of delocalization of the unpaired electron in the transition state were investigated. Because the ring formed during cyclization contains five sp(2) centers, electrocyclization via a pentadienyl-like resonance form was also considered. For comparison, similar calculations were performed for 4-penten-1-yl and related radicals. The factors that affect the activation energies of homolytic 5-endo-trig cyclization were determined. In the absence of steric or conformational effects, the endo cyclization to form the five-membered ring was strongly favored over exo cyclization to form the four-membered ring not only on thermodynamic grounds but also kinetically. When a substituent on the double bond was able to delocalize the unpaired electron in the transition state of the 4-exo path, the two modes of cyclization became kinetically comparable. These results have an important bearing on the generalization of the Baldwin-Beckwith rules, which classified the 5-endo-trig radical cyclization as a "disfavored" process.

CD40 ligand (CD40L, CD154) is overexpressed on T and B cells in systemic lupus erythematosus (SLE). Monocytes have been shown to contribute to immune-mediated pathology in SLE and to express CD40L under certain conditions. Therefore, we studied CD40L expression on lupus monocytes ex vivo, as well as after activation in vitro. A highly significant sevenfold increase in the frequency of CD40L-expressing peripheral monocytes from 23 SLE patients, compared to 16 healthy individuals (mean percentage of CD40L+CD14+ among CD14+ cells, 11.7 versus 1.6), was found by flow cytometry. Increased CD40L expression on monocytes correlated significantly with disease activity, elevated γ-globulin serum levels, as well as increased CD40L expression on T cells. CD40L expression by lupus monocytes was verified at both the mRNA and protein levels, while LPS stimulation was found to upregulate CD40L mRNA accumulation and surface protein expression. CD40L expression on activated lupus monocytes within anti-CD3-stimulated, mononuclear cell cultures was also enhanced compared to control-derived monocytes. These novel findings underscore the multiplicity of pathways through which monocytes may contribute to SLE pathology and suggest that T cell-independent CD40L-mediated cell to cell interactions may be also involved in humoral immune activation in SLE. © 2002 Elsevier Science (USA).

We examined the plasma concentration curve obtained over 6 h after the ingestion of 2 g of creatine (Cr) (equivalent to 2.3 g Cr·H2O) contained in meat or in solution in five non-users of creatine supplements. Peak plasma creatine concentration was lower after the ingestion of meat but was maintained close to this for a longer period. Measurements of the area under the plasma concentration curve indicated approximate bioequivalence of creatine contained in meat with the same dose supplied in a solution. In a separate study, we examined the plasma concentration-time curve after ingestion of solid Cr·H2O. Creatine ingested as a lozenge (crushed in the mouth and swallowed) or as a crystalline suspension in ice cold water resulted in a 20% lower peak concentration and 30-35% smaller area under the plasma creatine concentration curve than the same dose administered in solution. Despite a possibly lower bioavailability, 2.3 g Cr·H2O supplied in either solid form was nonetheless sufficient to raise the plasma concentration five- to six-fold in individuals with a mean body mass of 75.6 kg. We conclude that creatine administered as meat or in solid form is readily absorbed but may result in sligthly lower peak concentrations than when the same dose is ingested as a solution.

We examined the plasma concentration curve obtained over 6 h after the ingestion of 2 g of creatine (Cr) (equivalent to 2.3 g Cr·H2O) contained in meat or in solution in five non-users of creatine supplements. Peak plasma creatine concentration was lower after the ingestion of meat but was maintained close to this for a longer period. Measurements of the area under the plasma concentration curve indicated approximate bioequivalence of creatine contained in meat with the same dose supplied in a solution. In a separate study, we examined the plasma concentration-time curve after ingestion of solid Cr·H2O. Creatine ingested as a lozenge (crushed in the mouth and swallowed) or as a crystalline suspension in ice cold water resulted in a 20% lower peak concentration and 30-35% smaller area under the plasma creatine concentration curve than the same dose administered in solution. Despite a possibly lower bioavailability, 2.3 g Cr·H2O supplied in either solid form was nonetheless sufficient to raise the plasma concentration five- to six-fold in individuals with a mean body mass of 75.6 kg. We conclude that creatine administered as meat or in solid form is readily absorbed but may result in sligthly lower peak concentrations than when the same dose is ingested as a solution.

We examined the plasma concentration curve obtained over 6 h after the ingestion of 2 g of creatine (Cr) (equivalent to 2.3 g Cr·H2O) contained in meat or in solution in five non-users of creatine supplements. Peak plasma creatine concentration was lower after the ingestion of meat but was maintained close to this for a longer period. Measurements of the area under the plasma concentration curve indicated approximate bioequivalence of creatine contained in meat with the same dose supplied in a solution. In a separate study, we examined the plasma concentration-time curve after ingestion of solid Cr·H2O. Creatine ingested as a lozenge (crushed in the mouth and swallowed) or as a crystalline suspension in ice cold water resulted in a 20% lower peak concentration and 30-35% smaller area under the plasma creatine concentration curve than the same dose administered in solution. Despite a possibly lower bioavailability, 2.3 g Cr·H2O supplied in either solid form was nonetheless sufficient to raise the plasma concentration five- to six-fold in individuals with a mean body mass of 75.6 kg. We conclude that creatine administered as meat or in solid form is readily absorbed but may result in sligthly lower peak concentrations than when the same dose is ingested as a solution.

Le pretese continuarono con il successivo Premier turco Yilmaz, che estese la linea di provocazione mettendo in discussione ora lo stesso Trattato di pace di Losanna del 1923, trattato che costituisce il punto di riferimento giuridico obbligato dello status delle frontiere nel Mediterraneo orientale e dintorni. Circa ottanta anni dopo la firma e l’entrata in vigore di quel trattato di pace, il signor Yilmaz asserisce che ci sono “aree grigie” riguardo alla sovranità greca sugli isolotti e scogli dell’Egeo, che egli tuttavia rifiuta persistentemente di definire. Il governo turco ha costantemente respinto le richieste della Comunità internazionale di abbandonare le sue infondate pretese o di portarle davanti alla Corte Internazionale di Giustizia per una risoluzione pacifica. Ora la Turchia, contravvenendo a tutte le norme della legge e della logica, solleva pretese riguardo all’isola greca di Gaudos, il cui status giuridico era già stabilito fin dal 1913, dieci anni prima cioè del trattato di Losanna. In base all’articolo 4 del trattato di pace di Londra del 1913 la Turchia aveva già rinunciato a tutti i diritti di sovranità su Creta e Gaudos. In seguito il trattato di pace di Losanna del 1923 stabilì in modo più specifico le frontiere turche nell’area del Mediterraneo orientale, dal Mar Nero fino alla Persia. Dal momento che vi è compreso il Mare Egeo, il trattato di Losanna stabilisce specificamente che la sovranità turca è mantenuta solo su quelle isole che si trovano entro 3 miglia dalla costa turca, nonché sulle isole di Imbro, Tenedo e Rabbit. Questo regime giuridico nel Mediterraneo orientale è stato rispettato per quasi ottanta anni. Gli improvvisi tentativi turchi rivolti a rigettare, in maniera unilaterale, la validità di tale regime costituiscono una reale e incombente minaccia per la pace e la stabilità dell’intera regione.

The goal of this study is to estimate the relation between air temperature and precipitation in Greece and, thereafter, to define the regions of the covariability of the two parameters. For that purpose, the air temperature and precipitation mean monthly data of 30 meteorological stations, for the period 1950-2000, are analyzed. The first step is the application of Factor Analysis (FA) to each of the two variable groups of the seasonal air temperature and precipitation. The aim is to reduce the number of variables in each group and, more specific, to define the main significant factors for each parameter. The second step is the application of Canonical Correlation Analysis (CCA) to the factor scores of each parameter, derived by the use of PCA, so that the canonical pairs are extracted and the number of the pairs are equal to the minimum number of variables in either set. In the process, the computed canonical scores are correlated to the respective original data, aiming to define regions of positive and negative correlations between the canonical roots of the air temperature and precipitation.

The effect of the synoptic-scale atmospheric circulation on the urban heat island phenomenon over Athens, Greece, was investigated and quantified for a period of 2 yr. employing a neural network approach. A neural network model was appropriately designed and tested for the estimation of the heat island intensity at 23 stations during the examined period. The day-by-day synoptic-scale atmospheric circulation in the lower troposphere for the same period was classified into eight statistically distinct categories. The neural network model employed as an input the corresponding synoptic categories in conjunction with four meteorological parameters that are closely related to the urban heat island. It was found that the synoptic-scale circulation is a predominant input parameter, affecting considerably the heat island intensity. Also, it was demonstrated that the high pressure ridge mostly favors the heat island phenomenon and categories characterized by intense northerly component winds are responsible for its nonappearance or termination.

Benthic foraminifera widespread occurrence, numerical abundance and high fossilization potential rank them among the most powerful biological tools to reconstruct paleoenvironments. Their diversity and composition by suborder sometimes provide a general indication of the past environment, but the benthic taxonomic composition and recognition of faunal assemblages allow more detailed assessments of water depth, intertidal level, salinity, exposure to water turbulence, bottom oxygen concentrations, water temperature and carbon flux. The distribution of benthic foraminifera group is determined, and an analysis of the data is made in an effort to isolate and identify  important relationships between the distribution of organisms studied and the parameters of the physical environment. Benthic Foraminifera of the Upper Pliocene Tsoutsouras section (southern Crete) are analysed in order to investigate their relationship with paleodepth, sediment grain size and climatic changes. This paper encompasses the first detailed quantitative paleoenvironmental analysis based on benthic foraminifera from this area. Q-mode analysis revealed the existence of three associations. A. beccarii-Miliolids association corresponds to a rather shallow marine environment with vegetation in the neighbourhood. A. planorbis-Agglutinants is characterized by a decline in the salinity and the existence of moderate environmental stress which is associated by oxygen depletion and increase of primary productivity. In the upper part of the section V.bradyana – C. carinata association represents theestablishment of a restricted environment with abundant nutrient, where organic matter accumulates and infaunal opportunistic species capable of surviving in stressed conditions dominate.

Benthic foraminifera widespread occurrence, numerical abundance and high fossilization potential rank them among the most powerful biological tools to reconstruct paleoenvironments. Their diversity and composition by suborder sometimes provide a general indication of the past environment, but the benthic taxonomic composition and recognition of faunal assemblages allow more detailed assessments of water depth, intertidal level, salinity, exposure to water turbulence, bottom oxygen concentrations, water temperature and carbon flux. The distribution of benthic foraminifera group is determined, and an analysis of the data is made in an effort to isolate and identify  important relationships between the distribution of organisms studied and the parameters of the physical environment. Benthic Foraminifera of the Upper Pliocene Tsoutsouras section (southern Crete) are analysed in order to investigate their relationship with paleodepth, sediment grain size and climatic changes. This paper encompasses the first detailed quantitative paleoenvironmental analysis based on benthic foraminifera from this area. Q-mode analysis revealed the existence of three associations. A. beccarii-Miliolids association corresponds to a rather shallow marine environment with vegetation in the neighbourhood. A. planorbis-Agglutinants is characterized by a decline in the salinity and the existence of moderate environmental stress which is associated by oxygen depletion and increase of primary productivity. In the upper part of the section V.bradyana – C. carinata association represents theestablishment of a restricted environment with abundant nutrient, where organic matter accumulates and infaunal opportunistic species capable of surviving in stressed conditions dominate.

Benthic foraminifera widespread occurrence, numerical abundance and high fossilization potential rank them among the most powerful biological tools to reconstruct paleoenvironments. Their diversity and composition by suborder sometimes provide a general indication of the past environment, but the benthic taxonomic composition and recognition of faunal assemblages allow more detailed assessments of water depth, intertidal level, salinity, exposure to water turbulence, bottom oxygen concentrations, water temperature and carbon flux. The distribution of benthic foraminifera group is determined, and an analysis of the data is made in an effort to isolate and identify  important relationships between the distribution of organisms studied and the parameters of the physical environment. Benthic Foraminifera of the Upper Pliocene Tsoutsouras section (southern Crete) are analysed in order to investigate their relationship with paleodepth, sediment grain size and climatic changes. This paper encompasses the first detailed quantitative paleoenvironmental analysis based on benthic foraminifera from this area. Q-mode analysis revealed the existence of three associations. A. beccarii-Miliolids association corresponds to a rather shallow marine environment with vegetation in the neighbourhood. A. planorbis-Agglutinants is characterized by a decline in the salinity and the existence of moderate environmental stress which is associated by oxygen depletion and increase of primary productivity. In the upper part of the section V.bradyana – C. carinata association represents theestablishment of a restricted environment with abundant nutrient, where organic matter accumulates and infaunal opportunistic species capable of surviving in stressed conditions dominate.

Benthic foraminifera widespread occurrence, numerical abundance and high fossilization potential rank them among the most powerful biological tools to reconstruct paleoenvironments. Their diversity and composition by suborder sometimes provide a general indication of the past environment, but the benthic taxonomic composition and recognition of faunal assemblages allow more detailed assessments of water depth, intertidal level, salinity, exposure to water turbulence, bottom oxygen concentrations, water temperature and carbon flux. The distribution of benthic foraminifera group is determined, and an analysis of the data is made in an effort to isolate and identify  important relationships between the distribution of organisms studied and the parameters of the physical environment. Benthic Foraminifera of the Upper Pliocene Tsoutsouras section (southern Crete) are analysed in order to investigate their relationship with paleodepth, sediment grain size and climatic changes. This paper encompasses the first detailed quantitative paleoenvironmental analysis based on benthic foraminifera from this area. Q-mode analysis revealed the existence of three associations. A. beccarii-Miliolids association corresponds to a rather shallow marine environment with vegetation in the neighbourhood. A. planorbis-Agglutinants is characterized by a decline in the salinity and the existence of moderate environmental stress which is associated by oxygen depletion and increase of primary productivity. In the upper part of the section V.bradyana – C. carinata association represents theestablishment of a restricted environment with abundant nutrient, where organic matter accumulates and infaunal opportunistic species capable of surviving in stressed conditions dominate.

BACKGROUND: Psychiatric symptoms occur frequently in the course of AD, are a frequent contributor to institutionalization, predict cognitive decline and death, and often require treatment with psychotropic medications. Previous studies investigating the association between APOE genotype and psychiatric symptomatology in AD have reported contradictory results. OBJECTIVE: To determine whether APOE genotype predicts incident psychiatric symptomatology in patients with AD. METHODS: Eighty-seven patients with AD at early stages and no psychiatric history were followed semiannually for up to 9.3 years (mean 5.5 years) for development of delusions, illusions, hallucinations, behavioral symptoms, and depression. Cox proportional hazards models were used to examine the relative risk for incident psychiatric symptomatology (outcome) in relation to APOE genotype (predictor). RESULTS: The presence of one epsilon4 allele carried a 2.5-fold risk, whereas the presence of two epsilon4 alleles carried a 5.6-fold risk for development of delusions. The associations remained significant even when age, ethnicity, sex, education, duration of disease, and cognitive and functional performance were controlled for. The presence of two epsilon4 alleles was associated with reduced risk for developing hallucinations in the adjusted analysis only. No significant associations were detected between APOE genotype and the incidence of illusions, behavioral symptoms, or depression. CONCLUSION: The presence of one or more epsilon4 alleles is a significant predictor for the incidence of delusions in the course of AD.

In this paper we propose a new algorithm for the detection of clustered microcalcifications using mathematical morphology and artificial neural networks. Considering each mammogram as a topographic representation, each microcalcification appears as elevation constituting a regional maxima. Morphological filters are applied, in order to remove noise and regional maxima that doesn't correspond to calcifications. Each suspicious object is marked using a binary image and finally a feed forward neural network classifies every object achieving a rate of 90% true positive detections with 0.11 false positives per image.

We present ab initio calculations of the spin-dependent electronic transport in Fe/GaAs/Fe and Fe/ZnSe/Fe (001) junctions simulating the situation of a spin-injection experiment. We follow a ballistic Landauer-Buttiker approach for the calculation of the spin-dependent dc conductance in the linear-response regime, in the limit of zero temperature. We show that the bulk band structure of the leads and of the semiconductor, and even more the electronic structure of a clean and abrupt interface, are responsible for a current polarization and a magnetoresistance ratio of almost the ideal 100%, if the transport is ballistic. In particular, we study the significance of the transmission resonances caused by the presence of two interfaces.

We consider the spin injection from Fe into ZnSe and GaAs in the ballistic limit. By means of the ab initio screened Korringa-Kohn-Rostoker method we calculate the ground-state properties of epitaxial Fe\textbackslash{}ZnSe(001) and Fe\textbackslash{}GaAs(001) heterostructures. Three injection processes are considered: injection of hot electrons and injection of ``thermal{''} electrons with and without an interface barrier. The calculation of the conductance by the Landauer formula shows that these interfaces act like a nearly ideal spin filter, with spin polarization as high as 99%. This can be traced back to the symmetry of the band structure of Fe for normal incidence.

Determinations of the cadmium content of a wide variety of foodstuffs from the Greek market were carried out. The values detected ranged from <0.1 ng g-1 in alcoholic beverages to 1595.8 ng g-1 in large snails. The highest values were observed in molluscs and crustaceans (117.4ng g-1), followed by leafy vegetables (28.3 ng g-1), potatoes (22.3 ng g-1) and organs and offal (20.7 ng g-1), whereas the other food categories had a lower cadmium content. The results are comparable with those from the rest of Europe. Preliminary analytical data on the cadmium content of food samples of organic cultivation showed significantly lower values compared with those of samples of conventional produce.

This chapter describes all the recent advances in statistical and syntactic pattern recognition, along with a number of the most important hybrid efforts in pattern recognition methodology, which together with structural pattern recognition, are the future trends in pattern recognition applications' schemes.

Objectives. Ifosfamide, paclitaxel, and cisplatin have moderate single-agent activity in patients with metastatic or recurrent cancer of the uterine cervix. We administered a combination of these three agents to a large number of patients with metastatic or recurrent cervical cancer to evaluate its activity. Methods. Sixty patients were treated on an outpatient basis with Ifosfamide (I) 1500 mg/m2 intravenously over 1 h on Days 1-3, paclitaxel (T) 175 mg/m2 as a 3-h intravenous infusion on Day 1, and cisplatin (P) 75 mg/m2 intravenously over 2 h on Day 2 with granulocyte colony-stimulating factor (G-CSF) support. The chemotherapy was repeated every 4 weeks for a maximum of six courses. Results. Fifty-seven patients received at least two courses of treatment and are evaluable for response. Twenty-six patients (46%) achieved an objective response, including 19% complete and 27% partial responses. The median duration of response was 11.5 months and the median time to progression and survival for all patients were 8.3 and 18.6 months, respectively. Patients with excellent performance status, with disease recurrence outside the radiation field, and with nonsquamous tumors had the highest response rate and best survival. Some degree of neurotoxicity occurred in 44% of patients. Grade 3 or 4 toxicity included granulocytopenia in 26% of patients, anemia in 13%, thrombocytopenia in 7%, and neurotoxicity in 3%. Conclusion. The ITP regimen is relatively well tolerated and moderately active in patients with metastatic carcinoma of the uterine cervix. Patients more likely to benefit are those with nonsquamous histology, with excellent performance status, and with disease recurrence outside the radiation field. © 2002 Elsevier Science (USA).