Publications

Benthic foraminiferal composition assemblages and their temporal changes, ecological indices and foraminiferal densities are used to compare three coastal environments with different physicogeographical features in the Aegean Sea (coastal environment of Avdira–Vistonikos Gulf and Kitros–Thermaikos Gulf and open lagoonal environment of Vravron–South Evoikos Gulf). Three main foraminiferal assemblages have been recognized: a) “Assemblage A”; high degree of similarity between living and dead foraminiferal species, dominated byAmmonia beccarii, Elphidium spp. and relatively abundant and diverse miliolids, b) “Assemblage B1”; intermediate degree of similarity between live and dead assemblages, characterized by highly-abundant and well-diversified foraminiferal assemblages including the algal symbiont bearing Peneroplis pertusus together withAmmonia tepida and several small epiphytic rotaliids and miliolids, and c) “Assemblage B2”; absence of living individuals, strongly dominated by the opportunistic species A. tepida. Our results suggest a good comparison between living and dead assemblages from different coastal environments in the Aegean Sea, however the prevailing environmental conditions (vegetation cover, hydrodynamics, fresh water influx) have a strong impact on the taphonomic processes.

Transition-metal-oxide hybrids composed of high surface-to-volume ratio Ta2O5 matrices and a molecular analogue of transition metal oxides, tungsten polyoxometalates ([PW12O40]3-), are introduced herein as a charge storage medium in molecular nonvolatile capacitive memory cells. The polyoxometalate molecules are electrostatically self-assembled on a low-dimensional Ta2O5 matrix, functionalized with an aminosilane molecule with primary amines as the anchoring moiety. The charge trapping sites are located onto the metal framework of the electron-accepting molecular entities as well as on the molecule/oxide interfaces which can immobilize negatively charged mobile oxygen vacancies. The memory characteristics of this novel nanocomposite were tested using no blocking oxide for extraction of structure-specific characteristics. The film was formed on top of the 3.1 nm-thick SiO2/n-Si(001) substrates and has been found to serve as both SiO2/Si interface states' reducer (i.e., quality enhancer) and electron storage medium. The device with the polyoxometalates sandwiched between two Ta2O5 films results in enhanced internal scattering of carriers. Thanks to this, it exhibits a significantly larger memory window than the one containing the plain hybrid and comparable retention time, resulting in a memory window of 4.0 V for the write state and a retention time around 104 s without blocking medium. Differential distance of molecular trapping centers from the cell's gate and electronic coupling to the space charge region of the underlying Si substrate were identified as critical parameters for enhanced electron trapping for the first time in such devices. Implementing a numerical electrostatic model incorporating structural and electronic characteristics of the molecular nodes derived from scanning probe and spectroscopic characterization, we are able to interpret the hybrid's electrical response and gain some insight into the electrostatics of the trapping medium. © 2016 American Chemical Society.

We calculate the lowest ionisation and excitation energies in a variety of biologically important molecules, i.e. π-conjugated systems like DNA and RNA bases and isomers plus related heterocyclic molecules. For approximately half of these molecules, there are no experimental and theoretical/numerical data in the literature, as far as we know. These electronic transitions are mainly but not exclusively of π and π–π* character, respectively. We perform symmetry-constrained density functional theory (DFT) geometry optimisation at the B3LYP/6-311++G** level of theory. At the DFT-obtained ground-state geometries, we calculate vertical ionisation energies with ionisation potential coupled cluster with singles and doubles (IP-EOMCCSD) and vertical excitation energies with the completely renormalised equation of motion coupled cluster with singles, doubles, and non-iterative triples (CR-EOMCCSD(T)) method. We also investigate whether a simple semi-empirical Hückel-type model approach with novel parametrisation could provide reasonable estimates of the lowest π ionisation and π–π* excitation energies. Our coupled cluster (CC) results are in very good agreement with experimental data, while the Hückel-type model predictions generally follow the trends with some deviation. Finally, we investigate the effect of basis set in IP-EOMCCSD energies and we compare our CR-EOMCCSD(T) results with time-dependent DFT (TDDFT) ones.

Introduction: About 20–40% of patients with multiple myeloma (MM) will present with some degree of renal impairment (RI) and about 25% of patients will experience RI at later disease stages. Patients with MM and RI have poorer overall survival and are at higher risk of early death. Areas covered: The mechanisms of acute renal damage in MM are covered and the issues around diagnosis and renal evaluation response are discussed. The importance of optimal supportive care is stressed and the role and effectiveness of different anti-myeloma agents covered including the role of high cut-off hemodialysis, autologous stem cell transplantation and kidney transplant. Expert commentary: Outcomes of patients with RI and rates of renal recovery have improved with the use of novel anti-myeloma agents. Bortezomib-dexamethasone backbone regimes (±third agent) are the current first choice in newly diagnosed patients. In relapsed/refractory disease additional treatment options include newer novel agents. © 2016 Informa UK Limited, trading as Taylor & Francis Group.

Introduction: About 20–40% of patients with multiple myeloma (MM) will present with some degree of renal impairment (RI) and about 25% of patients will experience RI at later disease stages. Patients with MM and RI have poorer overall survival and are at higher risk of early death. Areas covered: The mechanisms of acute renal damage in MM are covered and the issues around diagnosis and renal evaluation response are discussed. The importance of optimal supportive care is stressed and the role and effectiveness of different anti-myeloma agents covered including the role of high cut-off hemodialysis, autologous stem cell transplantation and kidney transplant. Expert commentary: Outcomes of patients with RI and rates of renal recovery have improved with the use of novel anti-myeloma agents. Bortezomib-dexamethasone backbone regimes (±third agent) are the current first choice in newly diagnosed patients. In relapsed/refractory disease additional treatment options include newer novel agents. © 2016 Informa UK Limited, trading as Taylor & Francis Group.

Ependymal cells are multiciliated cells located in the wall of the lateral ventricles of the adult mammalian brain and are key components of the subependymal zone niche, where adult neural stem cells reside. Through the movement of their motile cilia, ependymal cells control the cerebrospinal fluid flow within the ventricular system from which they receive secreted molecules and morphogens controlling self-renewal and differentiation decisions of adult neural stem cells. Multiciliated ependymal cells become fully differentiated at postnatal stages however they are specified during mid to late embryogenesis from a population of radial glial cells. Here we discuss recent findings suggesting that 2 novel molecules, Mcidas and GemC1/Lynkeas are key players on radial glial specification to ependymal cells. Both proteins were initially described as cell cycle regulators revealing sequence similarity to Geminin. They are expressed in radial glial cells committed to the ependymal cell lineage during embryogenesis, while overexpression and knock down experiments showed that are sufficient and necessary for ependymal cell generation. We propose that Mcidas and GemC1/Lynkeas are key components of the molecular cascade that promotes radial glial cells fate commitment toward multiciliated ependymal cell lineage operating upstream of c-Myb and FoxJ1.

The rate of oxygen consumption is a vital marker indicating cellular function during lifetime under normal or metabolically challenged conditions. It is used broadly to study mitochondrial function (Artal-Sanz and Tavernarakis, 2009; Palikaras et al., 2015; Ryu et al., 2016) or investigate factors mediating the switch from oxidative phosphorylation to aerobic glycolysis (Chen et al., 2015; Vander Heiden et al., 2009). In this protocol, we describe a method for the determination of oxygen consumption rates in the nematode Caenorhabditis elegans.

We developed an extension of the layer-multiple-scattering method to photonic crystals comprising homogeneous layers of magneto-optical materials. The applicability of the method is demonstrated on a specific architecture of a magnetic garnet thin film coated with a square array of silver nanodisks, supported by a silica substrate. It is shown that enhanced Faraday rotation, driven by hybrid particle plasmon-film quasi-guided collective modes, can be achieved within selected regions of frequency, which can be tuned by properly choosing the geometric and material parameters involved. The results are analyzed in conjunction with numerical simulations by the finite-element method and a consistent interpretation of the underlying physics is provided. Our extended layer-multiple-scattering computational methodology provides a versatile framework for fast and accurate full electrodynamic calculations of magneto-optical structures, enabling physical insight.

The structural-microstructural characteristics and interfacial charge transfer are key issues to the development of efficient mixed phase TiO2 photocatalysts. In this work, the interplay of lattice deformation and microstrains as well as the identification of charge trapping sites and electron transfer were investigated for a series of nanostructured titania photocatalysts by X-ray powder diffraction analysis, Raman and electron paramagnetic resonance (EPR) spectroscopy. These mixed phase nanomaterials were selected as model sol-gel TiO2 systems based on their exceptional photocatalytic performance over a wide range of hazardous water pollutants (including degradation/mineralization of phenol, 2,4-dichlorophenoxyacetic acid and imazalil) under UV light. Lattice contraction with respect to the bulk anatase together with anisotropic microstrains was identified for the smallest (11 nm) anatase nanoparticles. Both effects gradually relaxed with the increase of calcination temperature and the concomitant particle growth, with microstrains scaling linearly with the relative change of the c-axis lattice constant and the broadening of the main anatase Raman mode. The growth of anatase nanoparticles at 1023 K with minimal lattice deformation and microstrains resulted in the optimal photocatalytic efficiency, outperforming the benchmark Aeroxide® P25 catalyst. This mixed phase catalyst comprised also larger, though more strained, rutile nanocrystals than P25, and presented an additional deeper electron trapping lattice site according to light-induced EPR measurements. More importantly, electron transfer from rutile to anatase lattice traps was identified by EPR under visible light in the mixed phase photocatalyst. The improved crystal quality of the anatase nanocrystals combined with the enhanced charge separation in anatase/rutile interfaces is concluded crucial to the design of competent solar photocatalytic nanomaterials. © 2016.

Mitophagy is a conserved, mitochondria-specific autophagic clearance process. We recently discovered an intricate regulatory network that balances mitophagy with mitochondrial biogenesis. Proper coordination of these opposing processes is important for stress resistance and longevity. Nodal regulatory factors that contribute to mitochondrial homeostasis have also been linked to carcinogenesis, highlighting mitophagy as a potential target for therapeutic interventions against cancer.

Within this study we introducea framework for assessing spatial fire risk and exposure to three important habitat types in Cephalonia island, Greece.Existing maps were used for plot allocation in orderto measure several fuel parameters in representative natural fuel complexes for site-specific fuel models development, as well as for collecting training and validation points for satellite data classification. The spatial extent of the fuel types and the canopy cover were delineated using a Landsat 8 OLI image acquired on 23-7-2015and the Support Vector Machines-(SVMs) machine learning algorithm. Subsequently, The Minimum Travel Time (MTT) algorithm, as it is embedded in FlamMap spatial fire simulation software, was applied in order to assess critical fire behavior parameters and exposure of Cephalonia's habitats under three different meteorological and fuel moisture scenarios. The outputs of this study may be used as an application of quantitative and probabilistic risk assessment for habitats conservation planning, prioritization and management of high value natural and cultural resources.

Sgr A* is an ideal target to study low-luminosity accreting systems. It has been recently proposed that properties of the accretion flow around Sgr A* can be probed through its interactions with the stellar wind of nearby massive stars belonging to the S-cluster. When a star intercepts the accretion disc, the ram and thermal pressures of the disc terminate the stellar wind leading to the formation of a bow shock structure. Here, a semi-analytical model is constructed which describes the geometry of the termination shock formed in the wind. With the employment of numerical hydrodynamic simulations, this model is both verified and extended to a region prone to Kelvin-Helmholtz instabilities. Because the characteristic wind and stellar velocities are in ∼108 cm s-1 range, the shocked wind may produce detectable X-rays via thermal bremsstrahlung emission. The application of this model to the pericentre passage of S2, the brightest member of the S-cluster, shows that the shocked wind produces roughly a month long X-ray flare with a peak luminosity of L ≈ 4 × 1033 erg s-1 for a stellar mass-loss rate, disc number density, and thermal pressure strength of dot{M}_w= 10^{-7} M_{⊙} yr^{-1}, nd = 105 cm-3, and α = 0.1, respectively. This peak luminosity is comparable to the quiescent X-ray emission detected from Sgr A* and is within the detection capabilities of current X-ray observatories. Its detection could constrain the density and thickness of the disc at a distance of ∼3000 gravitational radii from the supermassive black hole.

Human Immunodeficiency Virus type 1 (HIV-1) is characterised by vast genetic diversity. Globally circulating HIV-1 viruses are classified into distinct phylogenetic strains (subtypes, sub-subtypes) and several recombinant forms. Here we describe the characteristics and evolution of European HIV-1 epidemic over time through a review of published literature and updated queries of existing HIV-1 sequence databases. HIV-1 in Western and Central Europe was introduced in the early-1980s in the form of subtype B, which is still the predominant clade. However, in Eastern Europe (Former Soviet Union (FSU) countries and Russia) the predominant strain, introduced into Ukraine in the mid-1990s, is subtype A (A) with transmission mostly occurring in People Who Inject Drugs (PWID). In recent years, the epidemic is evolving towards a complex tapestry with an increase in the prevalence of non-B subtypes and recombinants in Western and Central Europe. Non-B epidemics are mainly associated with immigrants, heterosexuals and females but more recently, non-B clades have also spread amongst groups where non-B strains were previously absent - non-immigrant European populations and amongst men having sex with men (MSM). In some countries, non-B clades have spread amongst the native population, for example subtype G in Portugal and subtype A in Greece, Albania and Cyprus. Romania provides a unique case where sub-subtype F1 has predominated throughout the epidemic. In contrast, HIV-1 epidemic in FSU countries remains more homogeneous with Aclade predominating in all countries. The differences between the evolution of the Western epidemic and the Eastern epidemic may be attributable to differences in transmission risk behaviours, lifestyle and the patterns of human mobility. The study of HIV-1 epidemic diversity provides a useful tool by which we can understand the history of the pandemic in addition to allowing us to monitor the spread and growth of the epidemic over time.

OBJECTIVES: The European epidemiology of MRSA is changing with the emergence of community-associated MRSA (CA-MRSA) and livestock-associated MRSA (LA-MRSA). In this study, we investigated the molecular epidemiology of MRSA during 2 years in 13 ICUs in France, Greece, Italy, Latvia, Luxemburg, Portugal, Slovenia and Spain. METHODS: Surveillance cultures for MRSA from nose and wounds were obtained on admission and twice weekly from all patients admitted to an ICU for ≥3 days. The first MRSA isolate per patient was genotyped in a central laboratory by MLST, spa typing, agr typing and SCCmec (sub)typing. Risk factors for patients with an unknown history of MRSA colonization were identified. RESULTS: Overall, 14 390 ICU patients were screened, of whom 8519 stayed in an ICU for ≥3 days. Overall MRSA admission prevalence was 3.9% and ranged from 1.0% to 7.0% for individual ICUs. Overall MRSA acquisition rate was 2.5/1000 patient days at risk and ranged from 0.2 to 8/1000 patient days at risk per ICU. In total, 557 putative MRSA isolates were submitted to the central laboratory for typing, of which 511 (92%) were confirmed as MRSA. Each country had a distinct epidemiology, with ST8-IVc (UK-EMRSA-2/-6, USA500) being most prevalent, especially in France and Spain, and detected in ICUs in five of eight countries. Seventeen (3%) and three (<1%) isolates were categorized as CA-MRSA and LA-MRSA, respectively. Risk factors for MRSA carriage on ICU admission were age >70 years and hospitalization within 1 year prior to ICU admission. CONCLUSIONS: The molecular epidemiology of MRSA in 13 European ICUs in eight countries was homogeneous within, but heterogeneous between, countries. CA-MRSA and LA-MRSA genotypes and Panton-Valentine leucocidin-producing isolates were detected sporadically.

Molecular spontaneous emission and fluorescence depend strongly on the emitter local environment. Plasmonic nanoparticles provide excellent templates for tailoring fluorophore emission, as they exhibit potential for both fluorescence enhancement and quenching, depending on emitter positioning in the nanoparticle vicinity. Here we explore the influence of hitherto disregarded nonclassical effects on the description of emitter–plasmon hybrids, focusing on the roles of the metal nonlocal response and especially size-dependent plasmon damping. Through extensive modelling of metallic nanospheres and nanoshells coupled to dipole emitters, we show that within a purely classical description a remarkable fluorescence enhancement can be achieved. However, once departing from the local-response approximation, and particularly by implementing the recent generalised nonlocal optical response theory, which provides a more complete physical description combining electron convection and diffusion, we show that not only are fluorescence rates dramatically reduced compared to the predictions of the local description and the common hydrodynamic Drude model, but the optimum emitter–nanoparticle distance is also strongly affected. In this respect, experimental measurements of fluorescence, the theoretical description of which requires a precise concurrent evaluation of far- and near-field properties of the system, constitute a novel, more sensitive probe for assessing the validity of state-of-the-art nonclassical theories.

AIM: A morphometric analysis of the odontoid process of the A2 vertebra, in the Greek population, was conducted using CT scan. We aimed to determine the feasibility to use one or two screws when treating fractures of this anatomic element. PATIENTS AND METHODS: One hundred and fifteen patients (57 men) of a mean age of 48 years (16-95 years) underwent a cervical spine CT scan examination. The anterior-posterior and transverse diameters of the odontoid process were measured from the base, at 1-mm interval upward on axial CT images. The length from the tip of the odontoid process to the anterior-inferior angle of the body of the axis was calculated. Data concerning the height and weight of the examined patients were collected. RESULTS: The mean transverse and anterior-posterior distances were found to be 11.46 and 10.45 mm, respectively, for the upper end of the odontoid process. At the neck level of the odontoid process, the equivalent mean values were 11.12 and 8.73 mm, respectively, while at the base, these distances were found to be 13.84 and 12.3 mm, respectively. The mean distance from the tip of the odontoid to its base was 17.25 and 17.28 mm, respectively, while the mean distance from the tip of the dens to the anterior-inferior corner of the axis' body was 39.2 mm. Men showed greater values than women. CONCLUSIONS: In this study, it was shown that in the Greek population there is enough room for one 4.5-mm or one 3.5-mm cannulated screw to be used. The application of two 3.5-mm screws is feasible in 58.6 % of the male and 26.3 % of the female population. This confirms that the knowledge of the true dimensions of the odontoid process is of paramount importance before the proper management of fractured dens using the anterior screw technique.

This study attempts to analyse the narrative function and the theological significance of Jesus’ mother for the overall theology of the fourth gospel, mainly based on the exegetical method of narrative criticism.In the first part, the problem of the anonymity of Jesus’ mother in juxtapposition with the anonymity of the beloved disciple is dealt with. The second part consists of a detailed exegetical approach to the narrative of Jesus’ first sign in Cana within the Johannine narrative context as a whole. On this basis, in the third part a response to further relevant questions about the significance of Jesus’ mother according to the overall fourth gospel’s witness is attempted. The article is concluded with a summary of exegetical and theological positions, including a hypothesis about a possible Johannine background of the current Orthodox understanding of Theotokos.

Biophysical restoration or rehabilitation measures of land have demonstrated to be effective in many scientific projects and small-scale environmental experiments. However circumstances such as poverty, weak policies, or inefficient scientific knowledge transmission can hinder the effective upscaling of land restoration and the long term maintenance of proven sustainable use of soil and water. This may be especially worrisome in lands with harsh environmental conditions. This review covers recent efforts in landscape restoration and rehabilitation with a functional perspective aiming to simultaneously achieve ecosystem sustainability, economic efficiency, and social wellbeing. Water management and rehabilitation of ecosystem services in croplands, rangelands, forests, and coastlands are reviewed. The joint analysis of such diverse ecosystems provides a wide perspective to determine: (i) multifaceted impacts on biophysical and socio-economic factors; and (ii) elements influencing effective upscaling of sustainable land management practices. One conclusion can be highlighted: voluntary adoption is based on different pillars, i.e. external material and economic support, and spread of success information at the local scale to demonstrate the multidimensional benefits of sustainable land management. For the successful upscaling of land management, more attention must be paid to the social system from the first involvement stage, up to the long term maintenance.

We report the discovery of the new multi-periodic variable star GSC 0476-1362. Analysis of the observed light curves shows a complex variability pattern, as a result of a multi-periodic behaviour.

We report on the results of a ∼40-d multi-wavelength monitoring of the Be X-ray binary system IGR J05007-7047 (LXP 38.55). During that period the system was monitored in the X-rays using the Swift telescope and in the optical with multiple instruments. When the X-ray luminosity exceeded 1036 erg s-1 we triggered an XMM-Newton ToO observation. Timing analysis of the photon events collected during the XMM-Newton observation reveals coherent X-ray pulsations with a period of 38.551(3) s (1σ), making it the 17th known high-mass X-ray binary pulsar in the LMC. During the outburst, the X-ray spectrum is fitted best with a model composed of an absorbed power law (Γ = 0.63) plus a high-temperature blackbody (kT ∼2 keV) component. By analysing ∼12 yr of available OGLE optical data we derived a 30.776(5) d optical period, confirming the previously reported X-ray period of the system as its orbital period. During our X-ray monitoring the system showed limited optical variability while its IR flux varied in phase with the X-ray luminosity, which implies the presence of a disc-like component adding cooler light to the spectral energy distribution of the system.

PURPOSE: The aim of this study was to explore the relationship between muscle fiber conduction velocity (MFCV), fiber type composition, and power performance in participants with different training background. METHODS: Thirty-eight young males with different training background participated: sedentary (n = 10), endurance runners (n = 9), power trained (n = 10), and strength trained (n = 9). They performed maximal countermovement jumps (CMJ) and maximal isometric leg press for the measurement of the rate of force development (RFD). Resting vastus lateralis MFCV was measured with intramuscular microelectrodes on a different occasion, whereas muscle fiber type and cross-sectional area (CSA) of vastus lateralis were evaluated through muscle biopsies 1wk later. RESULTS: MFCV, CMJ power, RFD, and % CSA of type II and type IIx fibers were higher for the power-trained group (P < 0.001). No difference was found between sedentary participants and endurance runners in these variables, but both of these groups performed worse than strength/power participants. Close correlations were found between MFCV and fiber CSA as well as the % CSA of all fiber types as well as with RFD and CMJ power (r = 0.712-0.943, P < 0.005). Partial correlations revealed that the % CSA of IIx fibers dictates a large part of the correlation between MFCV and RFD, power performance. Significant models for the prediction of the % CSA of type IIa and type II as well as the CSA of all muscle fibers based upon MFCV, RFD, and CMJ were revealed (P = 0.000). CONCLUSION: MFCV is closely associated with muscle fiber % CSA. RFD and jumping power are associated with the propagation of the action potentials along the muscle fibers. This link is regulated by the size and the distribution of type II, and especially type IIx muscle fibers.

Early treatment, soon after infection, reduces HIV transmissions and benefits patients. The Transmission Reduction Intervention Project (TRIP) evaluated a network intervention to detect individuals recently infected (in the past 6 months). TRIP was conducted in Greece (2013-2015) and focused on drug injector networks. Based on HIV status, testing history, and the results of an assay to detect recent infections, TRIP classified drug injector "Seeds" into groups: Recent Seeds (RS), and Control Seeds with Long-term HIV infection (LCS). The network members of RS and LCS were traced for two steps. The analysis included 23 RS, 171 network members of the RS, 19 LCS, and 65 network members of the LCS. The per-seed number of recents detected in the network of RS was 5 times the number in the network of LCS (Ratio RS vs. LCS: 5.23; 95% Confidence Interval (CI): 1.54-27.61). The proportion of recents among HIV positives in the network of RS (27%) was approximately 3 times (Ratio RS vs. LCS: 3.30; 95% CI: 1.04-10.43) that in the network of LCS (8%). Strategic network tracing that starts with recently infected persons could support public health efforts to find and treat people early in their HIV infection.

Early treatment, soon after infection, reduces HIV transmissions and benefits patients. The Transmission Reduction Intervention Project (TRIP) evaluated a network intervention to detect individuals recently infected (in the past 6 months). TRIP was conducted in Greece (2013-2015) and focused on drug injector networks. Based on HIV status, testing history, and the results of an assay to detect recent infections, TRIP classified drug injector "Seeds" into groups: Recent Seeds (RS), and Control Seeds with Long-term HIV infection (LCS). The network members of RS and LCS were traced for two steps. The analysis included 23 RS, 171 network members of the RS, 19 LCS, and 65 network members of the LCS. The per-seed number of recents detected in the network of RS was 5 times the number in the network of LCS (Ratio RS vs. LCS: 5.23; 95% Confidence Interval (CI): 1.54-27.61). The proportion of recents among HIV positives in the network of RS (27%) was approximately 3 times (Ratio RS vs. LCS: 3.30; 95% CI: 1.04-10.43) that in the network of LCS (8%). Strategic network tracing that starts with recently infected persons could support public health efforts to find and treat people early in their HIV infection.

Background Renal impairment is a common complication of patients with multiple myeloma (MM). We aimed to evaluate the clinical significance of 2 newly discovered biomarkers of renal injury, cystatin C (CysC), a protein reflecting glomerular filtration rate, and neutrophil gelatinase-associated lipocalin (NGAL), a protein reflecting tubular injuries. Patients and Methods We studied 64 patients with newly diagnosed myeloma: 16 with asymptomatic (smoldering) MM and 48 with symptomatic myeloma; 8 patients with monoclonal gammopathy of undetermined significance (MGUS); and 20 healthy control subjects. Along with common blood and urine chemistry determinations, measurements of CysC, NGAL, β2-microglobulin, high-sensitivity C-reactive protein, and interleukin 6 were performed. Results We found that only patients with symptomatic MM had increased levels of CysC compared to controls (P <.01); that serum NGAL levels were elevated in all patients compared to controls P <.001; that NGAL strongly correlated with both estimation of glomerular filtration rate (EGFR) (CysC) and EGFR (Modification of Diet in Renal Disease [MDRD] formula) (r = 0.616, P <.0001; and r = -0.371, P <.01, respectively); that CysC showed strong correlation with EGFR (r = -0.782, P <.001) and with the International Scoring System (ISS) (more pronounced in patients with ISS-3); and that receiver operating characteristic curve analysis showed that NGAL values of > 50.5 μg/L have a 80.8% sensitivity and 86.4% specificity for EGFR < 60 mL/min (area under the curve = 0.764). Conclusion These findings suggest that both NGAL and CysC are very sensitive markers that reflect renal impairment in newly diagnosed patients with MM. The high levels of NGAL in asymptomatic patients and in MGUS patients support the hypothesis of the presence of renal damage in these patients early in the course of their disease and may reveal NGAL to be an early marker that predicts the presence of renal impairment in MM. © 2016 Elsevier Inc.

Here we report the first set of new and recurrent X-ray transients found in two XMM-Newton 100-ks pointings of the M31 northern disk on Jan 1 and 21 (see ATel #8825).

Here we report the second set of new and recurrent X-ray transients found in two XMM-Newton 100-ks pointings of the M31 northern disk on Jan 1 and 21 (see ATels #8825, #8826).

OJ287 has been monitored in the optical wavelength with small telescopes since the beginning of September, 2015. In November and December, an unprecedented outburst in the optical band was noticed (ATels: 8382, 8395, 8401, 8411, 8438), with OJ287 reaching 12.9 mag in the R filter.

The commingling of human remains often hinders forensic/physical anthropologists during the identification process, as there are limited methods to accurately sort these remains. This study investigates a new method for pair-matching, a common individualization technique, which uses digital three-dimensional models of bone: mesh-to-mesh value comparison (MVC). The MVC method digitally compares the entire three-dimensional geometry of two bones at once to produce a single value to indicate their similarity. Two different versions of this method, one manual and the other automated, were created and then tested for how well they accurately pair-matched humeri. Each version was assessed using sensitivity and specificity. The manual mesh-to-mesh value comparison method was 100 % sensitive and 100 % specific. The automated mesh-to-mesh value comparison method was 95 % sensitive and 60 % specific. Our results indicate that the mesh-to-mesh value comparison method overall is a powerful new tool for accurately pair-matching commingled skeletal elements, although the automated version still needs improvement.

This work describes the outcome of two field surveys in Lefkada Island, after the 17.11.2015 earthquake of Mw6.4 at its southwestern peninsula. Geo-environmental effects were observed throughout the western flanks of the mountain massif, parallel to the activated fault. Structural damage was mainly observed in the epicentral area where macroseismic intensity was assessed as VIII, based on registered damage and assumed vulnerability per building typology. Both modern and traditional buildings exhibited notable seismic performance. The distribution of the damage per building category present in the affected area is presented, based on site surveys and post-seismic usability characterization by the local Earthquake Rehabilitation Organization. The survey highlights the frequent presence of the so-called “pontelo” dual system at both ground floor and two-story stone masonry buildings at the western mountain villages. This structural type, unique within the Greek territory, revealed significant seismic performance and the need of engineering restoration measures is underlined.

This work deals with the effects of the 17.11.2015 earthquake with Mw6.4 occurred onshore at the SW part of Lefkada Island. The earthquake produced a large co-seismic horizontal displacement u=40 cm towards a SSW direction (N210), recorded at a near-field, permanent GPS station of NOA (PONT). Extensive geo-environmental and limited structural impacts were caused. Seismic effects have been extensively investigated during several in-situ surveys conducted by our research group and a thorough damage databank was constructed. Comparisonwith damage due to the previous strong event with Mw=6.2 occurred on 14.8.2003, showed that the effects of the current quake were significantly lower.Geo-environmental effects were observed throughout the western flanks of the mountain massif of the mainland, related with slope failures, rock falls, rock mass slides, leading thus to significant damage of several vital infrastructures. The building stock of the island comprising both modern and traditional buildings exhibited notable seismic performance during this earthquake. Structural damage was concentrated in the epicentral area where macroseismic intensity was assessed VIII, based on registered damage and vulnerability. The analysis of 3D strong ground motion recordings at two permanent accelerometric stations on the island and of the GNSS 1 Hz three-component data at PONT indicate directional dynamic effects, parallel with the T- principal axis of the event’s stress field and the regional slope dip that may likely have triggered extensive landslides. Moreover, the ground motion pattern indicates a rupture complexity involving two discrete sources. Besides the exceptional behavior of the buildings across the island, the spectral content of the strong ground motion has been found to be discrete from the elastic response of the low-rise traditional constructions, thus favoring amenablestructural damage distribution.The damage databank compiled in this work has been employed into a holistic building-by-building GIS scheme applying a vector base-map of the buildings footprints in the epicentral area available by the analysis of optical satellite imagery, undertaken within the framework of the RASOR project (http://www.rasor-project.eu). Thereafter, the poly-thematic outcome of the present study may be considered a valuable tool for the scientific community toward studying the seismic risk of Lefkada.

{The COnsortium for Small-scale MOdeling (COSMO) was formed in October 1998, and its general goal is to develop, improve and maintain a non-hydrostatic limited-area atmospheric model, while the Hellenic National Meteorological Service joined the consortium in 1999. The COSMO model has been designed both for operational numerical weather prediction (NWP) as well as various scientific applications on the meso-beta and meso-c scale. Two tornado case studies were selected to investigate the ability of COSMO model to depict the characteristics of severe convective weather, which favored the development of the associated storms. The first tornado occurred, close to Ag. Ilias village, 8 km northwestern from Aitoliko city over western Greece on February 7, 2013, while the second tornado developed close to Palio Katramio village, 8 km southern from Xanthi city over northern Greece on November 25, 2015. Although both tornadoes had a short lifetime, they caused significant impacts. The COSMO. GR atmospheric model was initialized with analysis boundary conditions obtained from the European Centre for Medium-Range Weather Forecasts (ECMWF). The resulting numerical products with spatial resolution of 0.020 degrees (similar to 2 km) over the geographical domain of Greece depicted very well the severe convective conditions close to tornadoes formation.}

{Towards the evaluation of the thermodynamic characteristics of a high impact tornadic event in Skala Lakonia, southern Peloponnese, in September 21, 2015, Weather Research and Forecasting (AR-WRF) mesoscale model was used. For the particular model setup used in this study, different configurations were pre-tested based on different spatial resolution and parameterization schemes. The current study downscales ECMWF reanalysis initial and boundary conditions to 300 m spatial resolution to assess the convective available potential energy (CAPE), the reflectivity perceived by radar (dBZ) and the energy helicity index (EHI). The validation was conducted using in situ and remote sensing observations of the surrounding area. The results illustrate deep convective activity with CAPE values indicating a strong instability in the region of interest. Furthermore, the model seems to capture well the southwesterly-northeasterly front propagation of the convective initiation of the storm, as well as the troughs that affected the south part of Peloponnese, assessing the pre-frontal nature of the particular tornadic event. Finally, the EHI values demonstrate the tornadic activity in the region of Skala Lakonia, as the model appears to simulate accurately the low pressure system along the east coast of the Lakonia Gulf.}

{A hurricane-like cyclone with an `eye', eyewall convection and strong winds affected central Mediterranean basin on 7-8 November 2014. The maximum observed sustained wind speed was 22 m/s (tropical storm strength) at Lampedusa. Significant damages were reported from this island and the coastal regions of eastern Sicily. Thus, it is essential to study medicanes and calibrate the numerical weather prediction models in order to simulate them adequately. Operational ECMWF analyses are used together with the non-hydrostatic Weather Research and Forecasting numerical model with the Advanced Research dynamic solver (WRF-ARW ver 3.7.1). The aims of this study are to simulate the system and investigate the sensitivity of the model on the microphysical scheme, the number of vertical levels and the global input dataset. The main characteristics of the medicane are represented in good agreement with observations and analyses, but, no single setup is able to provide the best reproduction of all its features.}

Abstract Measurements of nuclear magnetic dipole and electric quadrupole moments are considered quite important for the understanding of nuclear structure both near and far from the valley of stability. The recent advent of radioactive beams has resulted in a plethora of new, continuously flowing, experimental data on nuclear structure – including nuclear moments – which hinders the information management. A new, dedicated, public and user friendly online database (http://magneticmoments.info) has been created comprising experimental data of nuclear electromagnetic moments. The present database supersedes existing printed compilations, including also non-evaluated series of data and relevant meta-data, while putting strong emphasis on bimonthly updates. The scope, features and extensions of the database are reported.

Online bibliographic databases constitute the access to information supporting evidence-based practice. The purpose of the present survey is to evaluate the awareness, the use and the impact that online evidences have in clinical practice. An online survey was conducted using a 25 item questionnaire which was completed by 263 healthcare practitioners (nurses and doctors). Chi-square analysis and t-tests were used and comparisons between both groups were made. Multiple logistic regression to predict databases use was employed. Ninety-three percent (n = 206) of participants had heard about the online bibliographic databases; 5.7% of participant sample have heard about online databases but they do not use them. 18.3% was the total sample of non-users (n = 48). The main reason of using was filling a knowledge gap (50.7%), and the main reasons of not using were both that they use another information source and they don't need them to do their job. Both nurses and doctors believe that the use of online databases improves patient care it is a part of their legitimate clinical role. They need more training to improve their searching skills, enhancing them in everyday clinical place.

The competitive nature of ferromagnetism and superconductivity in Ferromagnet/Superconductor (FM/SC) hybrids has attracted much interest in the last decades. In particular, the superconducting magnetoresistance (SMR) observed in FM/SC/FM trilayers (TLs) is related to the manipulation of the transport properties of the SC interlayer by the magnetic domain structure of the FM outer layers with out-of-plane anisotropy. In our recent work [Sci. Rep. 5, 13420 (2015)], a phenomenological model was proposed that describes successfully the scaling of the SMR magnitude with the relevant macroscopic parameters and microscopic length scales of the SC and FM structural units. Based on this model, here we investigate the contribution of the parameters that affect indirectly the SMR magnitude and do not appear in the original model. To this end, the parameters of both the SC interlayer (i.e., the thickness, dSC, the mean free path, l, the coherence length, xi(0), etc.) and the FM outer layers (i.e., the thickness, d(FM)) are examined. The theoretical simulations presented here and experimental data unveil the indirect contribution of these parameters on the magnitude of the SMR and confirm the predictive power of the original phenomenological model. Accordingly, this model can be employed as a generic formula to combine successfully all involved parameters in every kind of FM/SC/FM TLs, ultimately optimizing the magnitude of the SMR. (C) 2016 AIP Publishing LLC.

The ferroelectric compound family Pb(ZrxTi1-x,)O-3 (PZT) is one of the most investigated and widely used piezoelectric materials. Optimization of the piezoelectric coefficients is observed for x similar to 0.52 (Pb(Zr0.52Ti0.48)O-3) and is further promoted by the increase of grain size (OS). However, in some cases the piezoelectric properties of Pb(Zr0.52Ti0.48)O-3 deteriorate upon processing due to the decrease of density, p, that is mostly ascribed to the appearance of byproduct phases. In the present study we discuss the influence of the processing conditions on the piezoelectric properties for polycrystalline Pb(Zr0.52Ti0.48)O-3, specifically focusing on the sintering temperature, 1100 degrees C Tsin <= 1250 degrees C. To this end, we use atomic force microscopy (AFM), Archimedes' method, x-ray diffraction (XRD) and a newly introduced local technique, based on a conventional optical microscope, which is further developed here to accommodate non-clamped specimens. The data obtained via this technique in the regime of relatively high electric fields evidence that the absolute piezoelectric coefficients, 141(i = x, y) show a non -monotonic behavior with an unexpectedly high maximum value broken vertical bar d broken vertical bar similar to 1100 pm V 1 at 7 = 1180 degrees C. These features are accompanied by a progressive increase of coercivity, reaching maximum value Ecj 4.5-5.0 kV cm I (i = x, y) at Tsin = 1250 degrees C. 'lb explain these findings, the Idzil coefficients are compared with the microstructure and compositional information, coming from AFM, Archimedes' method and XRD data. We conclude that the significantly high 141 values observed for samples prepared at Tsin = 1180 degrees C are motivated by the increase of mean GS, < GS >, while for Tsin > 1180 degrees C the decrease of density, p, ascribed to the appearance of byproduct phases, dominates and deteriorates Id2 I. These experimental results on broken vertical bar d broken vertical bar(T-sin) are reliably reproduced by a phenomenological model with reasonable assumptions for < GS > (7) 1 and rho(T(si)n). The unexpectedly high piezoelectric coefficients, broken vertical bar d(zi)broken vertical bar similar to 1100 pm V-1, reported here for the first time, are provocative and call for utilization of the introduced approach in the investigation of the respective properties of other compounds.

OJ287 goes through large optical flares twice each 12 years. The times of these flares have been predicted successfully now 5 times using a black hole binary model. In this model a secondary black hole goes around a primary black hole, impacting the accretion disk of the latter twice per orbital period, creating a thermal flare. Together with 6 flares from the historical data base, the set of flare timings determines uniquely the 7 parameters of the model: the two masses, the primary spin, the major axis, eccentricity and the phase of the orbit, plus a time delay parameter that gives the extent of time between accretion disk impacts and the related optical flares. Based on observations by the OJ287-15/16 Collaboration, OJ287 went into the phase of rapid flux rise on November 25, on the centenary of Einstein’s General Relativity, and peaked on December 5. At that time OJ287 was the brightest in over 30 years in optical wavelengths. The flare was of low polarization, and did not extend beyond the optical/UV region of the spectrum. On top of the main flare there were a number of small flares; their excess brightness correlates well with the simultaneous X-ray data. With these properties the main flare qualifies as the marker of the orbit of the secondary going around the primary black hole. Since the orbit solution is strongly over-determined, its parameters are known very accurately, at better than one percent level for the masses and the spin. The next flare is predicted to peak on July 28, 2019.Detailed monitoring of this event should allow us to test, for the first time, the celebrated black hole no-hair theorem for a massive black hole at the 10% level. The present data is consistent with the theorem only at a 30% level. The main difficulty in observing OJ287 from Earth at our predicted epoch is its closeness to the sun. Therefore, it is desirable to monitor OJ287 from a space-based telescope not in the vicinity of Earth. Unfortunately, this unique opportunity for testing the above celebrated theorem of General Relativity using OJ287 will not be available again until after several orbital cycles.The full list of participants in the OJ287-15/16 Collaboration is found in ApJL 819, L37, 2016.

Transurethral resection of bladder tumor (TURBT), radiotherapy, chemotherapy, or combinations can be used in patients with muscle-invasive bladder cancer (MIBC) not undergoing cystectomy. Nevertheless, unfitness for cystectomy is frequently associated with unfitness for other therapeutic modalities. We report the outcome of patients with MIBC who did not undergo cystectomy and did not receive cisplatin-based chemotherapy. Selection criteria for the study were nonmetastatic MIBC, no cystectomy, no cisplatin-based chemotherapy. Chemotherapy and/or radiotherapy should have been used aside from TURBT. Forty-nine patients (median age 79), managed between April 2001 and January 2012, were included in this analysis. Median Charlson Comorbidity Index was 5, while 76% were unfit for cisplatin. Treatment included radiotherapy (n = 7), carboplatin-based chemotherapy (n = 25), carboplatin-based chemotherapy followed by radiotherapy (n = 10), and radiochemotherapy (n = 7). Five-year event-free rate was 26% (standard error [SE] = 7) for overall survival, 23% (SE = 7) for progression-free survival, and 30 (SE = 8) for cancer-specific survival (CSS). Patients who were treated with combination of radiotherapy and chemotherapy had significantly longer CSS compared to those treated with radiotherapy or chemotherapy only (5-year CSS rate: 16% [SE 8] vs. 63% [SE 15], P = 0.053). Unfit-for-cystectomy patients frequently receive suboptimal nonsurgical treatment. Their outcome was poor. Combining chemotherapy with radiotherapy produced better outcomes and should be prospectively evaluated. © 2016 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

Transurethral resection of bladder tumor (TURBT), radiotherapy, chemotherapy, or combinations can be used in patients with muscle-invasive bladder cancer (MIBC) not undergoing cystectomy. Nevertheless, unfitness for cystectomy is frequently associated with unfitness for other therapeutic modalities. We report the outcome of patients with MIBC who did not undergo cystectomy and did not receive cisplatin-based chemotherapy. Selection criteria for the study were nonmetastatic MIBC, no cystectomy, no cisplatin-based chemotherapy. Chemotherapy and/or radiotherapy should have been used aside from TURBT. Forty-nine patients (median age 79), managed between April 2001 and January 2012, were included in this analysis. Median Charlson Comorbidity Index was 5, while 76% were unfit for cisplatin. Treatment included radiotherapy (n = 7), carboplatin-based chemotherapy (n = 25), carboplatin-based chemotherapy followed by radiotherapy (n = 10), and radiochemotherapy (n = 7). Five-year event-free rate was 26% (standard error [SE] = 7) for overall survival, 23% (SE = 7) for progression-free survival, and 30 (SE = 8) for cancer-specific survival (CSS). Patients who were treated with combination of radiotherapy and chemotherapy had significantly longer CSS compared to those treated with radiotherapy or chemotherapy only (5-year CSS rate: 16% [SE 8] vs. 63% [SE 15], P = 0.053). Unfit-for-cystectomy patients frequently receive suboptimal nonsurgical treatment. Their outcome was poor. Combining chemotherapy with radiotherapy produced better outcomes and should be prospectively evaluated. © 2016 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

Background Panobinostat plus bortezomib and dexamethasone significantly increased median progression-free survival compared with placebo plus bortezomib and dexamethasone in the phase 3 PANORAMA 1 trial. Here, we present the final overall survival analysis for this trial. Methods PANORAMA 1 is a randomised, placebo-controlled, double-blind, phase 3 trial of patients with relapsed or relapsed and refractory multiple myeloma with one to three previous treatments. Patients were randomly assigned (1:1) to receive panobinostat (20 mg orally) or placebo, with bortezomib (1·3 mg/m2 intravenously) and dexamethasone (20 mg orally), over two distinct treatment phases. In treatment phase 1 (eight 3-week cycles), patients received: panobinostat or placebo on days 1, 3, 5, 8, 10, and 12; bortezomib on days 1, 4, 8, and 11; and dexamethasone on days 1, 2, 4, 5, 8, 9, 11, and 12. During treatment phase 2 (four 6-week cycles with a 2 weeks on, 1 week off schedule), panobinostat or placebo was given three times a week, bortezomib was administered once a week, and dexamethasone was given on the days of and following bortezomib administration. The primary endpoint was progression-free survival; overall survival was a key secondary endpoint. This study is registered at ClinicalTrials.gov, NCT01023308. Findings Between Jan 21, 2010, and Feb 29, 2012, 768 patients were enrolled into the study and randomly assigned to receive either panobinostat (n=387) or placebo (n=381), plus bortezomib and dexamethasone. At data cutoff (June 29, 2015), 415 patients had died. Median overall survival was 40·3 months (95% CI 35·0–44·8) in those who received panobinostat, bortezomib, and dexamethasone versus 35·8 months (29·0–40·6) in those who received placebo, bortezomib, and dexamethasone (hazard ratio [HR] 0·94, 95% CI 0·78–1·14; p=0·54). Of patients who had received at least two previous regimens including bortezomib and an immunomodulatory drug, median overall survival was 25·5 months (95% CI 19·6–34·3) in 73 patients who received panobinostat, bortezomib, and dexamethasone versus 19·5 months (14·1–32·5) in 74 who received placebo (HR 1·01, 95% CI 0·68–1·50). Interpretation The overall survival benefit with panobinostat over placebo with bortezomib and dexamethasone was modest. However, optimisation of the regimen could potentially prolong treatment duration and improve patients' outcomes, although further trials will be required to confirm this. Funding Novartis Pharmaceuticals. © 2016 Elsevier Ltd

Background Panobinostat plus bortezomib and dexamethasone significantly increased median progression-free survival compared with placebo plus bortezomib and dexamethasone in the phase 3 PANORAMA 1 trial. Here, we present the final overall survival analysis for this trial. Methods PANORAMA 1 is a randomised, placebo-controlled, double-blind, phase 3 trial of patients with relapsed or relapsed and refractory multiple myeloma with one to three previous treatments. Patients were randomly assigned (1:1) to receive panobinostat (20 mg orally) or placebo, with bortezomib (1·3 mg/m2 intravenously) and dexamethasone (20 mg orally), over two distinct treatment phases. In treatment phase 1 (eight 3-week cycles), patients received: panobinostat or placebo on days 1, 3, 5, 8, 10, and 12; bortezomib on days 1, 4, 8, and 11; and dexamethasone on days 1, 2, 4, 5, 8, 9, 11, and 12. During treatment phase 2 (four 6-week cycles with a 2 weeks on, 1 week off schedule), panobinostat or placebo was given three times a week, bortezomib was administered once a week, and dexamethasone was given on the days of and following bortezomib administration. The primary endpoint was progression-free survival; overall survival was a key secondary endpoint. This study is registered at ClinicalTrials.gov, NCT01023308. Findings Between Jan 21, 2010, and Feb 29, 2012, 768 patients were enrolled into the study and randomly assigned to receive either panobinostat (n=387) or placebo (n=381), plus bortezomib and dexamethasone. At data cutoff (June 29, 2015), 415 patients had died. Median overall survival was 40·3 months (95% CI 35·0–44·8) in those who received panobinostat, bortezomib, and dexamethasone versus 35·8 months (29·0–40·6) in those who received placebo, bortezomib, and dexamethasone (hazard ratio [HR] 0·94, 95% CI 0·78–1·14; p=0·54). Of patients who had received at least two previous regimens including bortezomib and an immunomodulatory drug, median overall survival was 25·5 months (95% CI 19·6–34·3) in 73 patients who received panobinostat, bortezomib, and dexamethasone versus 19·5 months (14·1–32·5) in 74 who received placebo (HR 1·01, 95% CI 0·68–1·50). Interpretation The overall survival benefit with panobinostat over placebo with bortezomib and dexamethasone was modest. However, optimisation of the regimen could potentially prolong treatment duration and improve patients' outcomes, although further trials will be required to confirm this. Funding Novartis Pharmaceuticals. © 2016 Elsevier Ltd

HIV strains continuously evolve, tend to recombine, and new circulating variants are being discovered. Novel strains complicate efforts to develop a vaccine against HIV and may exhibit higher transmission efficiency and virulence, and elevated resistance to antiretroviral agents. The United Nations Joint Programme on HIV/AIDS (UNAIDS) set an ambitious goal to end HIV as a public health threat by 2030 through comprehensive strategies that include epidemiological input as the first step of the process. In this context, molecular epidemiology becomes invaluable as it captures trends in HIV evolution rates that shape epidemiological pictures across several geographical areas. This review briefly summarizes the molecular epidemiology of HIV among people who inject drugs (PWID) in Europe and Asia. Following high transmission rates of subtype G and CRF14_BG among PWID in Portugal and Spain, two European countries, Greece and Romania, experienced recent HIV outbreaks in PWID that consisted of multiple transmission clusters including subtypes B, A, F1, and recombinants CRF14_BG and CRF35_AD. The latter was first identified in Afghanistan. Russia, Ukraine, and other Former Soviet Union (FSU) states are still facing the devastating effects of epidemics in PWID produced by A(also known as IDU-A), B(known as IDU-B), and CRF03_AB. In Asia, CRF01_AE and subtype B (Western B and Thai B) travelled from PWID in Thailand to neighboring countries. Recombination hotspots in South China, Northern Myanmar, and Malaysia have been generating several intersubtype and inter-CRF recombinants (e.g. CRF07_BC, CRF08_BC, CRF33_01B etc.), increasing the complexity of HIV molecular patterns.

Micro-Abstract Acute oxaliplatin neurotoxicity and chronic sensory cumulative neuropathy were investigated in a long-term study of 31 consecutive patients with advanced colorectal cancer. Our results improve the knowledge of acute neurotoxicity and support the finding of the persistence of the sensory nerve deficits for years after the cessation of oxaliplatin therapy. © 2016 Elsevier Inc.

Micro-Abstract Acute oxaliplatin neurotoxicity and chronic sensory cumulative neuropathy were investigated in a long-term study of 31 consecutive patients with advanced colorectal cancer. Our results improve the knowledge of acute neurotoxicity and support the finding of the persistence of the sensory nerve deficits for years after the cessation of oxaliplatin therapy. © 2016 Elsevier Inc.

Ποιες είναι οι απαρχές των εκπαιδευτικών συστημάτων; Ποιες αρχές καθόρισαν τις «πειθαρχίες» και τη «γραμματική του σχολείου»; Πως διαγράφονται οι σχέσεις «εξουσίας-γνώσης» στο χώρο της εκπαίδευσης; Ποιες ιδέες επηρέασαν και διαμόρφωσαν τον παιδαγωγικό «λόγο» και τις εκπαιδευτικές «πρακτικές»; Ποιος είναι ο ρόλος της εκπαίδευσης στις σύγχρονες «οικονομίες και κοινωνίες της γνώσης»; Πώς καθορίζεται το σύγχρονο πλαίσιο των «ικανοτήτων» των μαθητών και των «προσόντων» των εκπαιδευτικών; Ποιοι είναι οι σύγχρονοι «λόγοι» και οι «πρακτικές» που χαρακτηρίζουν το σχολείο ως «οργανισμό και ως κοινότητα μάθησης»; Τα παραπάνω είναι μερικά από τα βασικά ερωτήματα που διατρέχουν τα κεφάλαια του παρόντος βιβλίου. Σκοπός των συγγραφέων είναι να αναλύσουν τη μετάβαση από την αρχαιολογία της εκπαίδευσης στη γενεαλογία του εκπαιδευτικού θεσμού. Στο βιβλίο παρουσιάζονται αναλυτικά θεωρήσεις και πολιτικές που επηρέασαν τη διαμόρφωση του παιδαγωγικού «λόγου» και των εκπαιδευτικών πρακτικών κατά τη διάρκεια του 19ου και του 20ου αιώνα. Έμφαση δίδεται στην ανάλυση των σχέσεων «εξουσίας-γνώσης» στο χώρο της εκπαίδευσης, και στις σχέσεις μεταξύ του εκπαιδευτικού «λόγου» και των κοινωνικών πρακτικών. Εξετάζονται οι επιδράσεις της «παγκοσμιοποίησης» και της «κοινωνίας της γνώσης» στον εκπαιδευτικό θεσμό. Αναλύονται οι σύγχρονες «πολιτικές της γνώσης» που συνδέονται με νέες θεωρίες και διαδικασίες μάθησης, με τη μετάβαση από το γνωσιοκεντρικό στο «ικανοκεντρικό» μοντέλο μάθησης, με τον μεταβαλλόμενο ρόλο και τις αλλαγές στα προσόντα των εκπαιδευτικών, με τον μετασχηματισμό του σχολείου σε «οργανισμό και σε κοινότητα μάθησης», με τη μετάβαση από τις «πειθαρχικές κοινωνίες» στις «κοινωνίες ελέγχου» και την προοπτική μιας ολοκληρωτικά παιδαγωγούμενης κοινωνίας. πάνω είναι μερικά από τα βασικά ερωτήματα που διατρέχουν τα κεφάλαια του παρόντος βιβλίου. Σκοπός των συγγραφέων είναι να αναλύσουν τη μετάβαση από την αρχαιολογία της εκπαίδευσης στη γενεαλογία του εκπαιδευτικού θεσμού. Στο βιβλίο παρουσιάζονται αναλυτικά θεωρήσεις και πολιτικές που επηρέασαν τη διαμόρφωση του παιδαγωγικού ≪λόγου≫ και των εκπαιδευτικών πρακτικών κατά τη διάρκεια του 19ου και του 20ου αιώνα. Έμφαση δίδεται στην ανάλυση των σχέσεων ≪εξουσίας-γνώσης≫ στο χώρο της εκπαίδευσης, και στις σχέσεις μεταξύ του εκπαιδευτικού ≪λόγου≫ και των κοινωνικών πρακτικών. Εξετάζονται οι επιδράσεις της ≪παγκοσμιοποίησης≫ και της ≪κοινωνίας της γνώσης≫ στον εκπαιδευτικό θεσμό. Αναλύονται οι σύγχρονες ≪πολιτικές της γνώσης≫ που συνδέονται με νέες θεωρίες και διαδικασίες μάθησης, με τη μετάβαση από το γνωσιοκεντρικό στο ≪ικανοκεντρικό≫ μοντέλο μάθησης, με τον μεταβαλλόμενο ρόλο και τις αλλαγές στα προσόντα των εκπαιδευτικών, με τον μετασχηματισμό του σχολείου σε ≪οργανισμό και σε κοινότητα μάθησης≫, με τη μετάβαση από τις ≪πειθαρχικές κοινωνίες≫ στις ≪κοινωνίες ελέγχου≫ και την προοπτική μιας ολοκληρωτικά παιδαγωγούμενης κοινωνίας. - See more at: http://www.grigorisbooks.gr/product/1718/%CF%80%CE%B1%CE%B9%CE%B4%CE%B1%CE%B3%CF%89%CE%B3%CE%B9%CE%BA%CE%AE-%CE%BA%CE%B1%CE%B9-%CE%B5%CE%BA%CF%80%CE%B1%CE%AF%CE%B4%CE%B5%CF%85%CF%83%CE%B7#sthash.1NcC0VDg.dpuf Ποιες είναι οι απαρχές των εκπαιδευτικών συστημάτων; Ποιες αρχές καθόρισαν τις ≪πειθαρχίες≫ και τη ≪γραμματική του σχολείου≫; Πως διαγράφονται οι σχέσεις ≪εξουσίας-γνώσης≫ στο χώρο της εκπαίδευσης; Ποιες ιδέες επηρέασαν και διαμόρφωσαν τον παιδαγωγικό ≪λόγο≫ και τις εκπαιδευτικές ≪πρακτικές≫; Ποιος είναι ο ρόλος της εκπαίδευσης στις σύγχρονες ≪οικονομίες και κοινωνίες της γνώσης≫; Πώς καθορίζεται το σύγχρονο πλαίσιο των ≪ικανοτήτων≫ των μαθητών και των ≪προσόντων≫ των εκπαιδευτικών; Ποιοι είναι οι σύγχρονοι ≪λόγοι≫ και οι ≪πρακτικές≫ που χαρακτηρίζουν το σχολείο ως ≪οργανισμό και ως κοινότητα μάθησης≫;  Τα παραπάνω είναι μερικά από τα βασικά ερωτήματα που διατρέχουν τα κεφάλαια του παρόντος βιβλίου. Σκοπός των συγγραφέων είναι να αναλύσουν τη μετάβαση από την αρχαιολογία της εκπαίδευσης στη γενεαλογία του εκπαιδευτικού θεσμού. Στο βιβλίο παρουσιάζονται αναλυτικά θεωρήσεις και πολιτικές που επηρέασαν τη διαμόρφωση του παιδαγωγικού ≪λόγου≫ και των εκπαιδευτικών πρακτικών κατά τη διάρκεια του 19ου και του 20ου αιώνα. Έμφαση δίδεται στην ανάλυση των σχέσεων ≪εξουσίας-γνώσης≫ στο χώρο της εκπαίδευσης, και στις σχέσεις μεταξύ του εκπαιδευτικού ≪λόγου≫ και των κοινωνικών πρακτικών. Εξετάζονται οι επιδράσεις της ≪παγκοσμιοποίησης≫ και της ≪κοινωνίας της γνώσης≫ στον εκπαιδευτικό θεσμό. Αναλύονται οι σύγχρονες ≪πολιτικές της γνώσης≫ που συνδέονται με νέες θεωρίες και διαδικασίες μάθησης, με τη μετάβαση από το γνωσιοκεντρικό στο ≪ικανοκεντρικό≫ μοντέλο μάθησης, με τον μεταβαλλόμενο ρόλο και τις αλλαγές στα προσόντα των εκπαιδευτικών, με τον μετασχηματισμό του σχολείου σε ≪οργανισμό και σε κοινότητα μάθησης≫, με τη μετάβαση από τις ≪πειθαρχικές κοινωνίες≫ στις ≪κοινωνίες ελέγχου≫ και την προοπτική μιας ολοκληρωτικά παιδαγωγούμενης κοινωνίας. - See more at: http://www.grigorisbooks.gr/product/1718/%CF%80%CE%B1%CE%B9%CE%B4%CE%B1%CE%B3%CF%89%CE%B3%CE%B9%CE%BA%CE%AE-%CE%BA%CE%B1%CE%B9-%CE%B5%CE%BA%CF%80%CE%B1%CE%AF%CE%B4%CE%B5%CF%85%CF%83%CE%B7#sthash.1NcC0VDg.dpuf

BACKGROUND & AIMS: Risk scores for hepatocellular carcinoma (HCC) developed in Asians offer poor-moderate predictability in Caucasian patients with chronic hepatitis B (CHB). This nine center cohort study aimed to develop and validate an accurate HCC risk score in Caucasian CHB patients treated with the current oral antivirals, entecavir/tenofovir. METHODS: We included 1815 adult Caucasians with CHB and no HCC at baseline who received entecavir/tenofovir for 12 months. Using data from eight centers (derivation dataset, n=1325), a HCC risk score was developed based on multivariable Cox models and points system for simplification. Harrell's c-index was used as discrimination, bootstrap for internal validation and the data from the 9(th) and largest center (validation dataset, n=490) for external validation. RESULTS: The 5-year cumulative HCC incidence rates were 5.7% and 8.4% in the derivation and validation dataset, respectively. In the derivation dataset, age, gender, platelets and cirrhosis were independently associated with HCC. The PAGE-B score was developed based on age, gender and platelets (c-index=0.82, 0.81 after bootstrap validation). The addition of cirrhosis did not substantially improve the discrimination (c-index=0.84). The predictability of PAGE-B score was similar (c-index=0.82) in the validation dataset. Patients with PAGE-B 9, 10-17, 18 had 5-year cumulative HCC incidence rates of 0%, 3%, 17% in the derivation and 0%, 4%, 16% in the validation dataset. CONCLUSION: PAGE-B, which is based only on baseline patients' age, gender and platelets, represents a simple and reliable score for prediction of the 5-year HCC risk in Caucasian CHB patients under entecavir/tenofovir.

Panobinostat is a potent pan-deacetylase inhibitor that affects the growth and survival of multiple myeloma (MM) cells through alteration of epigenetic mechanisms and protein metabolism. Panobinostat plus bortezomib and dexamethasone (PAN-BTZ-Dex) led to a significant increase in progression-free survival (PFS) vs placebo plus bortezomib and dexamethasone (Pbo-BTZ-Dex) in patients with relapsed or relapsed and refractoryMMin the phase 3PANORAMA1 trial. This subgroup analysis evaluated outcomes in patients in the PANORAMA 1 trial based on prior treatment: A prior immunomodulatory drug (IMiD; n 5 485), prior bortezomib plus an IMiD (n 5 193), and ≥2 prior regimens including bortezomib and an IMiD (n5147). Median PFS with PAN-BTZ-Dex vs Pbo-BTZ-Dex across subgroups was as follows: prior IMiD (12.3 vs 7.4 months; hazard ratio [HR], 0.54; 95% confidence interval [CI], 0.43-0.68), prior bortezomib plus IMiD (10.6 vs 5.8 months; HR, 0.52;95%CI, 0.36-0.76),and ≥2 prior regimens including bortezomib and an IMiD (12.5 vs 4.7 months; HR, 0.47; 95% CI, 0.31-0.72). Common grade 3/4 adverse events and laboratory abnormalities in patients who received PAN-BTZ-Dex across the prior treatment groups included thrombocytopenia, lymphopenia, neutropenia, diarrhea, and asthenia/ fatigue. Incidence of on-treatment deaths among patients who received prior bortezomib and an IMiD (regardless of number of prior regimens) was similar between treatment arms. This analysis demonstrated a clear PFS benefit of 7.8 months with PAN-BTZ-Dex among patients who received ‡2 prior regimens including bortezomib and an IMiD, a population with limited treatment options and poorer prognosis. This trial was registered at www.clinicaltrials.gov as #NCT01023308. © 2016 by The American Society of Hematology.

Panobinostat is a potent pan-deacetylase inhibitor that affects the growth and survival of multiple myeloma (MM) cells through alteration of epigenetic mechanisms and protein metabolism. Panobinostat plus bortezomib and dexamethasone (PAN-BTZ-Dex) led to a significant increase in progression-free survival (PFS) vs placebo plus bortezomib and dexamethasone (Pbo-BTZ-Dex) in patients with relapsed or relapsed and refractoryMMin the phase 3PANORAMA1 trial. This subgroup analysis evaluated outcomes in patients in the PANORAMA 1 trial based on prior treatment: A prior immunomodulatory drug (IMiD; n 5 485), prior bortezomib plus an IMiD (n 5 193), and ≥2 prior regimens including bortezomib and an IMiD (n5147). Median PFS with PAN-BTZ-Dex vs Pbo-BTZ-Dex across subgroups was as follows: prior IMiD (12.3 vs 7.4 months; hazard ratio [HR], 0.54; 95% confidence interval [CI], 0.43-0.68), prior bortezomib plus IMiD (10.6 vs 5.8 months; HR, 0.52;95%CI, 0.36-0.76),and ≥2 prior regimens including bortezomib and an IMiD (12.5 vs 4.7 months; HR, 0.47; 95% CI, 0.31-0.72). Common grade 3/4 adverse events and laboratory abnormalities in patients who received PAN-BTZ-Dex across the prior treatment groups included thrombocytopenia, lymphopenia, neutropenia, diarrhea, and asthenia/ fatigue. Incidence of on-treatment deaths among patients who received prior bortezomib and an IMiD (regardless of number of prior regimens) was similar between treatment arms. This analysis demonstrated a clear PFS benefit of 7.8 months with PAN-BTZ-Dex among patients who received ‡2 prior regimens including bortezomib and an IMiD, a population with limited treatment options and poorer prognosis. This trial was registered at www.clinicaltrials.gov as #NCT01023308. © 2016 by The American Society of Hematology.

All orthopaedic fluoroscopic procedures performed using C-arm guidance were monitored for 1 y. The type of procedure, fluoroscopy time (T), kerma-area product (KAP) values and number of radiographs (F) were recorded. The two most often performed techniques were as follows: intramedullary nailing (IMN) of intertrochanteric/peritrochanteric (IP) fractures (101 cases, 49.3 %) and antergrade IMN of femur or tibia shaft (TS) fractures (28 cases, 13.7 %). For the remaining procedures, none accounted for >5 %, categorised as 'various' (76 cases, 37 %). Large variations in T, KAP and F were observed. For IMN of IP fractures, antergrade IMN of femur and TS fractures and for various procedures, respectively, median values were T--2.1, 2.2 and 0.6 min, KAP--6.3, 6.3 and 0.6 Gy cm(-2) and F--21, 2.2 and 6.7. The patient doses during fluoroscopically guided procedures are relatively low compared with other interventional procedures.

The aim of the study was to examine whether physical and technical performance deterioration after a water polo game is related to the athletes' conditioning level. Blood lactate concentration was measured during a 5 × 200-m incremental swimming test in 10 male water polo athletes to calculate the velocities corresponding to 4.0, 5.0, and 10.0 mmol·L lactate concentration (V4, V5, and V10, respectively) and define their conditioning level. All athletes participated in 5 competitive water polo games. Before (Pre), at half time (Mid), and after (Post) the first 2 games, handgrip strength and repeated sprint ability (8 × 20-m) were measured. Pre and Post the next 2 games, ball throwing velocity, shooting accuracy, and 400-m swim were evaluated. Pre, Mid, and Post the last game, the eggbeater kick test was performed. Handgrip strength, repeated sprint ability, 400-m swim performance, and ball shooting accuracy decreased after the game (8.4 ± 6.2%, 6.3 ± 3.4%, 7.0 ± 4.1%, and 20.3 ± 23.4%, respectively, p ≤ 0.05). V4, V5, and V10 were not significantly correlated with changes in physical or technical performance after the game. Performance in 400-m swim correlated with V4 and V5 whereas changes in 400-m swim Pre-Post, correlated with changes in ball shooting accuracy and throwing velocity (r = 0.73 and r = 0.80, p ≤ 0.05). These data suggest that V4, V5, and V10 may not correlate with performance decline in water polo. Interestingly, the 400-m swim test is connected with the decline in repeated sprints, ball shooting accuracy, and throwing velocity after a water polo game in well-trained athletes.

INTRODUCTION: We present a case of peripherally inserted central catheter (PICC) port placement where the catheter had been malpositioned to the persistent left superior vena cava. METHODS: Despite the obvious elevation of the P-wave signaling proximity of the catheter tip to the sinus node, the catheter was not in the desired location within the superior vena cava or the right atrium, because of the presence of a persistent left superior vena cava. Computed tomography was used in order to locate the catheter. RESULTS: The catheter was located in the persistent left superior vena cava. CONCLUSIONS: Malpositioning of the catheter in the persistent left superior vena cava occurs in 0.3%-0.5% of patients. The catheter was subsequently removed.

We investigated the phase behavior of thin film, thickness h  100 nm, mixtures of a polystyrene-b-poly(2-vinylpyridine) (PS-b-P2VP) diblock copolymer with star-shaped polystyrene (SPS) molecules of varying functionalities f, where 4 < f < 64, and molecular weights per arm Marm. The miscibility of the system and the surface composition varied appreciably with Marm and f. For large values of Marm, regardless of f, the miscibility of the system was qualitatively similar to that of linear chain PS/PS-b-P2VP mixtures – the copolymer chains aggregate to form micelles, each composed of an inner P2VP core and PS corona, which preferentially segregate to the free surface. On the other hand, for large f and small Marm, SPS molecules preferentially resided at the free surface. Moreover, blends containing SPS molecules with the highest values of f and lowest values of Marm were phase separated. These observations are rationalized in terms of competing entropic interactions and the dependence of the surface tension of the star shaped molecules on Marm and f.

An extension of the layer-multiple-scattering method to phononic crystals of poroelastic spheres immersed in a fluid medium is developed. The applicability of the method is demonstrated on specific examples of close-packed fcc crystals of submerged water-saturated meso- and macroporous silica microspheres. It is shown that, by varying the pore size and/or the porosity, the transmission, reflection, and absorption spectra of finite slabs of these crystals are significantly altered. Strong absorption, driven by the slow waves in the poroelastic material and enhanced by multiple scattering, leads to negligible transmittance over an extended frequency range, which might be useful for practical applications in broadband acoustic shielding. The results are analyzed by reference to relevant phononic dispersion diagrams in the viscous and inertial coupling limits, and a consistent interpretation of the underlying physics is provided.

In this paper, we present a combined photometric, spectroscopic, and orbital period study of three early-type eclipsing binary systems: XZ Aql, UX Her, and AT Peg. As a result, we have derived the absolute parameters of their components and, on that basis, we discuss their evolutionary states. Furthermore, we compare their parameters with those of other binary systems and with theoretical models. An analysis of all available up-to-date times of minima indicated that all three systems studied here show cyclic orbital changes; their origin is discussed in detail. Finally, we performed a frequency analysis for possible pulsational behavior, and as a result we suggest that XZ Aql hosts a δ Scuti component.

Blobs, or quasi-spherical emission regions containing relativistic particles and magnetic fields, are often assumed ad hoc in emission models of relativistic astrophysical jets, yet their physical origin is still not well understood. Here, we employ a suite of large-scale 2D particle-in-cell simulations in electron-positron plasmas to demonstrate that relativistic magnetic reconnection can naturally account for the formation of quasi-spherical plasmoids filled with high-energy particles and magnetic fields. Our simulations extend to unprecedentedly long temporal and spatial scales, so we can capture the asymptotic physics independently of the initial setup. We characterize the properties of the plasmoids, continuously generated as a self-consistent by-product of the reconnection process: they are in rough energy equipartition between particles and magnetic fields; the upper energy cutoff of the plasmoid particle spectrum is proportional to the plasmoid width w, corresponding to a Larmor radius ∼0.2 w; the plasmoids grow in size at ∼0.1 of the speed of light, with most of the growth happening while they are still non-relativistic (`first they grow'); their growth is suppressed once they get accelerated to relativistic speeds by the field line tension, up to the Alfvén speed (`then they go'). The largest plasmoids reach a width wmax ∼ 0.2 L independently of the system length L, they have nearly isotropic particle distributions and contain the highest energy particles, whose Larmor radius is ∼0.03 L. The latter can be regarded as the Hillas criterion for relativistic reconnection. We briefly discuss the implications of our results for the high-energy emission from relativistic jets and pulsar winds.

The conditions for the occurrence of strong magnetotransverse anisotropy in light scattering by a single gyrotropic sphere are investigated by means of rigorous full electrodynamic multipole calculations. It is shown that composite magnetoplasmonic spherical scatterers with a core–shell morphology can induce large and tunable plasmon-driven Hall photon currents, which appear even in the case of subwavelength particles. Explicit results for silver-coated bismuth-substituted yttrium iron garnet nanospheres are presented and analyzed.

Lake Ohrid is located at the border between FYROM (Former Yugoslavian Republic of Macedonia) and Albania and formed during the latest phases of Alpine orogenesis. It is the deepest, the largest and the oldest tectonic lake in Europe. To better understand the paleoclimatic and paleoenvironmental evolution of Lake Ohrid, deep drilling was carried out in 2013 within the framework of the Scientific Collaboration on Past Speciation Conditions (SCOPSCO) project that was funded by the International Continental Scientific Drilling Program (ICDP). Preliminary results indicate that lacustrine sedimentation of Lake Ohrid started between 1.2 and 1.9 Ma ago. Here we present new pollen data (selected percentage and concentration taxa/groups) of the uppermost  ∼  200 m of the 569 m long DEEP core drilled in the depocentre of Lake Ohrid. The study is the fruit of a cooperative work carried out in several European palynological laboratories. The age model of this part of the core is based on 10 tephra layers and on tuning of biogeochemical proxy data to orbital parameters. According to the age model, the studied sequence covers the last  ∼  500 000 years at a millennial-scale resolution ( ∼  1.6 ka) and records the major vegetation and climate changes that occurred during the last 12 (13 only pro parte) marine isotope stages (MIS). Our results indicate that there is a general good correspondence between forested/non-forested periods and glacial–interglacial cycles of the marine isotope stratigraphy. The record shows a progressive change from cooler and wetter to warmer and drier interglacial conditions. This shift in temperature and moisture availability is visible also in vegetation during glacial periods. The period corresponding to MIS11 (pollen assemblage zone OD-10, 428–368 ka BP) is dominated by montane trees such as conifers. Mesophilous elements such as deciduous and semi-deciduous oaks dominate forest periods of MIS5 (PASZ OD-3, 129–70 ka BP) and MIS1 (PASZ OD-1, 14 ka BP to present). Moreover, MIS7 (PASZ OD-6, 245–190 ka) shows a very high interglacial variability, with alternating expansions of montane and mesophilous arboreal taxa. Grasslands (open vegetation formations requiring relatively humid conditions) characterize the earlier glacial phases of MIS12 (PASZ OD-12, 488–459 ka), MIS10 (corresponding to the central part of PASZ OD-10, 428–366 ka) and MIS8 (PASZ OD-7, 288–245 ka). Steppes (open vegetation formations typical of dry environments) prevail during MIS6 (OD-5 and OD-4, 190–129 ka) and during MIS4-2 (PASZ OD-2, 70–14 ka). Our palynological results support the notion that Lake Ohrid has been a refugium area for both temperate and montane trees during glacials. Closer comparisons with other long southern European and Near Eastern pollen records will be achieved through ongoing high-resolution studies.

Renal impairment (RI) is a major comorbidity in patients with multiple myeloma (MM). Here we present the pooled safety and efficacy analysis of three clinical trials (MM-002, MM-003, and MM-010) of pomalidomide + low-dose dexamethasone (POM + LoDEX) in patients with moderate RI (creatinine clearance [CrCl] ≥ 30 to <60 mL/min) and without RI (≥ 60 mL/min). Trial protocols were approved by the institutional review board of each site involved. Patients with RI were older than patients without RI, although other baseline characteristics were similar. The dosing and safety profile of POM + LoDEX was similar across RI subgroups. Median overall response rate, progression-free survival, time to progression, and duration of response were not significantly different between RI subgroups. However, patients with vs. without RI had significantly shorter median overall survival (10.5 vs. 14.0 months, respectively; p =.004). This analysis demonstrates that POM + LoDEX is a safe and effective treatment for patients with moderate RI. The trials were registered at ClinicalTrials.gov as NCT00833833 (MM-002), NCT01311687 (MM-003), and NCT01712789 (MM-010) and at EudraCT as 2010-019820-30 (MM-003) and 2012-001888-78 (MM-010). © 2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

Renal impairment (RI) is a major comorbidity in patients with multiple myeloma (MM). Here we present the pooled safety and efficacy analysis of three clinical trials (MM-002, MM-003, and MM-010) of pomalidomide + low-dose dexamethasone (POM + LoDEX) in patients with moderate RI (creatinine clearance [CrCl] ≥ 30 to <60 mL/min) and without RI (≥ 60 mL/min). Trial protocols were approved by the institutional review board of each site involved. Patients with RI were older than patients without RI, although other baseline characteristics were similar. The dosing and safety profile of POM + LoDEX was similar across RI subgroups. Median overall response rate, progression-free survival, time to progression, and duration of response were not significantly different between RI subgroups. However, patients with vs. without RI had significantly shorter median overall survival (10.5 vs. 14.0 months, respectively; p =.004). This analysis demonstrates that POM + LoDEX is a safe and effective treatment for patients with moderate RI. The trials were registered at ClinicalTrials.gov as NCT00833833 (MM-002), NCT01311687 (MM-003), and NCT01712789 (MM-010) and at EudraCT as 2010-019820-30 (MM-003) and 2012-001888-78 (MM-010). © 2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

Aims: We present a comprehensive X-ray study of the population of supernova remnants (SNRs) in the Large Magellanic Cloud (LMC). Using primarily XMM-Newton observations, we conduct a systematic spectral analysis of LMC SNRs to gain new insight into their evolution and the interplay with their host galaxy. Methods: We combined all the archival XMM-Newton observations of the LMC with those of our Very Large Programme LMC survey. We produced X-ray images and spectra of 51 SNRs, out of a list of 59 objects compiled from the literature and augmented with newly found objects. Using a careful modelling of the background, we consistently analysed all the X-ray spectra and measure temperatures, luminosities, and chemical compositions. The locations of SNRs are compared to the distributions of stars, cold gas, and warm gas in the LMC, and we investigated the connection between the SNRs and their local environment, characterised by various star formation histories. We tentatively typed all LMC SNRs, in order to constrain the ratio of core-collapse to type Ia SN rates in the LMC. We also compared the column densities derived from X-ray spectra to H I maps, thus probing the three-dimensional structure of the LMC. Results: This work provides the first homogeneous catalogue of the X-ray spectral properties of SNRs in the LMC. It offers a complete census of LMC remnants whose X-ray emission exhibits Fe K lines (13% of the sample), or reveals the contribution from hot supernova ejecta (39%), which both give clues to the progenitor types. The abundances of O, Ne, Mg, Si, and Fe in the hot phase of the LMC interstellar medium are found to be between 0.2 and 0.5 times the solar values with a lower abundance ratio [α/Fe] than in the Milky Way. The current ratio of core-collapse to type Ia SN rates in the LMC is constrained to NCC/NIa=1.35(-0.24+0.11), which is lower than in local SN surveys and galaxy clusters. Our comparison of the X-ray luminosity functions of SNRs in Local Group galaxies (LMC, SMC, M31, and M33) reveals an intriguing excess of bright objects in the LMC. Finally, we confirm that 30 Doradus and the LMC Bar are offset from the main disc of the LMC to the far and near sides, respectively. Based on observations obtained with XMM-Newton, an ESA science mission with instruments and contributions directly funded by ESA Member States and NASA.

A population pharmacokinetic (PK) model and exposure-response (E-R) analysis was developed using data collected from 5 phase 1b/2 and 2 phase 3 studies in subjects with multiple myeloma. Subjects receiving intravenous infusion on 2 consecutive days each week for 3 weeks (days 1, 2, 8, 9, 15, and 16) in each cycle at doses ranging from 15 to 20/56 mg/m2 (20 mg/m2 in cycle 1 and, if tolerated, escalated to 56 mg/m2 on day 8 of cycle 1). The population PK analysis indicated that among all the covariates tested, the only statistically significant covariate was body surface area on carfilzomib clearance; however, this covariate was unlikely to be clinically significant. Despite inclusion of different populations (relapsed or relapsed/refractory), treatments (carfilzomib monotherapy or combination therapy), infusion lengths (2 to 10 minutes or 30 minutes), and different doses, the E-R analysis of efficacy showed that after adjusting for baseline characteristics, higher area under the concentration-time curve was associated with improved overall response rate (ORR), from 15 to 20/56 mg/m2. No positive relationships between maximum concentration and ORR were identified, indicating that ORR would not be expected to be impacted by infusion length. For safety end points, no statistically significant relationship between exposure and increasing risk of adverse events was identified. The results of an E-R analysis provided strong support for a carfilzomib dose at 20/56 mg/m2 as a 30-minute infusion for monotherapy and combination therapy. This article illustrates an example of application of E-R analysis to support labeling dose recommendation in the absence of extensive clinical data. © 2016, The American College of Clinical Pharmacology.

On July 17, 2015 a forest fire that broke out in the southern part of Epidavros Limira peninsula (Laconia, southeastern Peloponnese), expanded rapidly due to strong winds blowing in the area and raged out of control for two days, inducing substantial damage to agriculture, livestock farming, buildings and infrastructure and causing one fatality. Innovative GIS-based methods were developed and implemented for the first time in a fire-affected area in Greece for mapping the post-fire erosion, flood and landslide hazards and risks. Geomorphological, geological, tectonic, hydrological, meteorological and land-use data along with a WorldView-2 satellite image and post-fire field observations were evaluated and used. A newly developed method was applied for assessing the erosion hazard. Analytic Hierarchy Process and Weighted Linear Combination methods were used for assessing the post-fire landslide susceptibility. The HEC-RAS model was used for hydraulic simulation and assessment of flood risk under post-fire conditions. Post-fire erosion, flood and landslide hazard and risk maps were constructed for the affected area delineating locations with very low, low, moderate, high or very high hazard and risk of erosion, flood and landslide respectively. The developed methodology is a useful post-fire hazard and risk assessment tool and can be applied by state authorities to assess the geo-environmental impact of fire disasters in areas with similar environmental conditions.

Monoclonal antibodies (mAbs) are a recent addition to multiple myeloma (MM) therapies and a number of mAbs directed at myeloma cell surface molecules are in development. Daratumumab is a CD38 mAb that has demonstrated substantial activity and good tolerability in four phase I, phase I/II and phase II studies as monotherapy, as well as in combination with current standard treatments in MM. The positive results obtained in the relapsed/refractory setting in patients with advanced-stage disease and in a small number of patients with newly diagnosed disease provide the rationale for the investigation of the agent in a number of ongoing phase III trials. mAbs are generally better tolerated than conventional chemotherapy; however, their use requires other special considerations. Such factors include those common to all mAbs, namely infusion-related reactions, but also factors that are observed with mAbs used in myeloma, such as interference with response assessment, or factors that are related to CD38 mAbs such as daratumumab, for instance blood typing interference. Our review provides an overview of the results from the daratumumab clinical trials conducted to date, as well as practical management considerations for the use of daratumumab based on our experience with the agent. © 2016 Springer International Publishing Switzerland.

Monoclonal antibodies (mAbs) are a recent addition to multiple myeloma (MM) therapies and a number of mAbs directed at myeloma cell surface molecules are in development. Daratumumab is a CD38 mAb that has demonstrated substantial activity and good tolerability in four phase I, phase I/II and phase II studies as monotherapy, as well as in combination with current standard treatments in MM. The positive results obtained in the relapsed/refractory setting in patients with advanced-stage disease and in a small number of patients with newly diagnosed disease provide the rationale for the investigation of the agent in a number of ongoing phase III trials. mAbs are generally better tolerated than conventional chemotherapy; however, their use requires other special considerations. Such factors include those common to all mAbs, namely infusion-related reactions, but also factors that are observed with mAbs used in myeloma, such as interference with response assessment, or factors that are related to CD38 mAbs such as daratumumab, for instance blood typing interference. Our review provides an overview of the results from the daratumumab clinical trials conducted to date, as well as practical management considerations for the use of daratumumab based on our experience with the agent. © 2016 Springer International Publishing Switzerland.

OBJECTIVES: To evaluate the prevalence and its clinical characteristics of psoriatic arthritis (PsA) in a specialized psoriasis clinic of a University Hospital. METHODS: In this retrospective study, 278 patients with psoriasis were evaluated between 2011 and 2013. RESULTS: The study included 278 patients with psoriasis: 144 (52%) were male and 134 (48%) female. Their median age was 51.41 with median psoriasis presenting age of 34.52 years. Referring to the type of psoriasis, 86% presented with plaque psoriasis, 5% guttate, 2% palms and soles, 2% inverse, 1% pustular and 4% with psoriasis of more than one type. Nail disease appeared in 121 patients (43.5%) and scalp disease in 175 (63%). Of these patients, 85 (30%) had PsA, whereas 51% of patients with PsA had psoriatic nail disease. With reference to the PsA type, 43 (51%) patients presented with polyarthritis, 10 (12%) with oligoarthritis, 7 (8%) with axial arthritis, whereas the rest 25 of them (31%) had PsA of more than one type. The subgroup of patients with PsA had significantly higher rates of comorbidities including arterial hypertension, diabetes and hypercholesterolaemia compared to non-PsA patients with 41% vs. 17% (P = 0.001), 20% vs. 8% (P = 0.021) and 41% vs. 19% (P = 0.004), respectively. CONCLUSION: The prevalence of PsA among patients with psoriasis was relatively higher in Greece compared to other ethnic-based studies. Comorbidities related to life expectancy were more frequent. As there is a high percentage of undiagnosed cases with active arthritis among patients with psoriasis, dermatologists should be aware of PsA clinical signs in order to recognize it earlier and provide successful treatment.

OJ 287 is a quasi-periodic quasar with roughly 12 year optical cycles. It displays prominent outbursts that are predictable in a binary black hole model. The model predicted a major optical outburst in 2015 December. We found that the outburst did occur within the expected time range, peaking on 2015 December 5 at magnitude 12.9 in the optical R-band. Based on Swift/XRT satellite measurements and optical polarization data, we find that it included a major thermal component. Its timing provides an accurate estimate for the spin of the primary black hole, χ =0.313+/- 0.01. The present outburst also confirms the established general relativistic properties of the system such as the loss of orbital energy to gravitational radiation at the 2% accuracy level, and it opens up the possibility of testing the black hole no-hair theorem with 10% accuracy during the present decade.

Botezomib-based induction is highly effective for the treatment of newly diagnosed multiple myeloma (NDMM). We investigated the outcomes of NDMM patients who failed to respond to bortezomib-based induction in a real-life clinical setting. In a cohort of 295 consecutive NDMM patients in 3 medical centers, 74 (25%) failed to achieve at least partial response after 4 induction cycles, and were classified as non-responsive. Compared to induction responders, they were older, more frequently anemic, had a higher incidence of del17p and ISS-3, and a worse performance status. In multivariable analysis, bortezomib-based induction failure occurred in 25% of patients and was the strongest independent factor predicting mortality with a 5-fold hazard ratio (95% CI 1.44-8.68). Three-year overall survival in responsive vs. non-responsive patients were 76% vs. 53%, respectively (p < 0.0001). Survival from time of salvage second-line treatment was significantly shorter among induction non-responders vs. responders (25 months vs. not-reached, p = 0.024). © 2015 Taylor & Francis.

Botezomib-based induction is highly effective for the treatment of newly diagnosed multiple myeloma (NDMM). We investigated the outcomes of NDMM patients who failed to respond to bortezomib-based induction in a real-life clinical setting. In a cohort of 295 consecutive NDMM patients in 3 medical centers, 74 (25%) failed to achieve at least partial response after 4 induction cycles, and were classified as non-responsive. Compared to induction responders, they were older, more frequently anemic, had a higher incidence of del17p and ISS-3, and a worse performance status. In multivariable analysis, bortezomib-based induction failure occurred in 25% of patients and was the strongest independent factor predicting mortality with a 5-fold hazard ratio (95% CI 1.44-8.68). Three-year overall survival in responsive vs. non-responsive patients were 76% vs. 53%, respectively (p < 0.0001). Survival from time of salvage second-line treatment was significantly shorter among induction non-responders vs. responders (25 months vs. not-reached, p = 0.024). © 2015 Taylor & Francis.

The International Committee for the Taxonomy and Nomenclature of Viruses does not rule on virus classifications below the species level. The definition of species for viruses cannot be clearly defined for all types of viruses. The complex and interesting epidemiology of Human Immunodeficiency Viruses demands a detailed and informative nomenclature system, while at the same time it presents challenges such that many of the rules need to be flexibly applied or modified over time. This review outlines the nomenclature system for primate lentiviruses and provides an update on new findings since the last review was written in 2000.

MicroRNAs are small, non-coding RNAs which regulate post-transcriptionally hundreds of target mRNAs. Given that their expression is deregulated in several cancer types, they represent potential diagnostic, prognostic, and predictive biomarkers, as well as next-generation therapeutic targets. Nevertheless, the involvement of miRNAs in non-melanoma skin cancer, a cancer type with increasing prevalence, is not extensively studied, and their comprehensive characterization as regard to the initiation, promotion, and progression stages is missing. To this end, we exploited a well-established multistage mouse skin carcinogenesis model in order to identify miRNAs consistently implicated in different stages of skin carcinogenesis. The cell lines comprising this model were subjected to miRNA expression profiling using microarrays, followed by bioinformatics analysis and validation with Q-PCR, as well as treatment with miRNA modulators. We showed that among all deregulated miRNAs in our system, only a functionally coherent group consisting of the miR-200 family members and miR-205-5p displays a pattern of progressive co-downregulation from the early toward the most aggressive stages of carcinogenesis. Their overlapping, co-regulated putative targets are potentially inter-associated and, of these, the EMT-related Rap1a is overexpressed toward aggressive stages. Ectopic expression of miR-205-5p in spindle cancer cells reduces Rap1a, mitigates cell invasiveness, decreases proliferation, and delays tumor onset. We conclude that deregulation of this miRNA group is primarily associated with aggressive phenotypes of skin cancer cells. Restoration of the miR-205-5p member of this group in spindle cells reduces the expression of critical, co-regulated targets that favor cancer progression, thus reversing the EMT characteristics. © 2015 Wiley Periodicals, Inc.

The absolute power of a relativistic black hole jet includes the power in the magnetic field, the leptons, the hadrons, and the radiated photons. A power analysis of a relativistic radio/γ-ray blazar jet leads to bifurcated leptonic synchrotron-Compton (LSC) and leptohadronic synchrotron (LHS) solutions that minimize the total jet power. Higher Doppler factors with increasing peak synchrotron frequency are implied in the LSC model. Strong magnetic fields {B}\prime ≳ 100 {{G}} are found for the LHS model with variability times ≲ {10}3 {{s}}, in accord with highly magnetized, reconnection-driven jet models. Proton synchrotron models of ≳ 100 {GeV} blazar radiation can have sub-Eddington absolute jet powers, but models of dominant GeV radiation in flat spectrum radio quasars require excessive power.

A variety of medications have been implicated in the causation of thrombotic microangiopathy (TMA). Recently, a few case reports have emerged of TMA attributed to the proteasome inhibitors (PI) bortezomib and carfilzomib in patients with multiple myeloma. The aim of this case series was to better characterize the role of PI in the etiology of drug-induced TMA. We describe eleven patients from six medical centers from around the world who developed TMA while being treated with PI. The median time between medication initiation and diagnosis of TMA was 21 days (range 5 days to 17 months). Median laboratory values at diagnosis included hemoglobin—7.5 g dL−1, platelet count—20 × 109/L, LDH—698 U L−1, creatinine—3.12 mg dL−1. No patient had any other cause of TMA, including ADAMTS13 inhibition, other malignancy or use of any other medication previously associated with TMA. Nine patients had resolution of TMA without evidence of hemolysis after withdrawal of PI. Two patients had stabilization of laboratory values but persistent evidence of hemolysis despite medication withdrawal. One patient had recurrence of TMA with rechallenge of PI. There is a strong level of evidence that PI can cause DITMA. In evaluating patients with suspected TMA, PI use should be recognized as a potential etiology, and these medications should be discontinued promptly if thought to be the cause of TMA. Am. J. Hematol. 91:E348–E352, 2016. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

A variety of medications have been implicated in the causation of thrombotic microangiopathy (TMA). Recently, a few case reports have emerged of TMA attributed to the proteasome inhibitors (PI) bortezomib and carfilzomib in patients with multiple myeloma. The aim of this case series was to better characterize the role of PI in the etiology of drug-induced TMA. We describe eleven patients from six medical centers from around the world who developed TMA while being treated with PI. The median time between medication initiation and diagnosis of TMA was 21 days (range 5 days to 17 months). Median laboratory values at diagnosis included hemoglobin—7.5 g dL−1, platelet count—20 × 109/L, LDH—698 U L−1, creatinine—3.12 mg dL−1. No patient had any other cause of TMA, including ADAMTS13 inhibition, other malignancy or use of any other medication previously associated with TMA. Nine patients had resolution of TMA without evidence of hemolysis after withdrawal of PI. Two patients had stabilization of laboratory values but persistent evidence of hemolysis despite medication withdrawal. One patient had recurrence of TMA with rechallenge of PI. There is a strong level of evidence that PI can cause DITMA. In evaluating patients with suspected TMA, PI use should be recognized as a potential etiology, and these medications should be discontinued promptly if thought to be the cause of TMA. Am. J. Hematol. 91:E348–E352, 2016. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

We request a 50 ks observation of a pulsating (P~170 s), accretingwhite dwarf binary located in the Large Magellanic Cloud. The systemwas serendipitously detected off-axis during analysis of an archivalXMM-Newton observation (2013) that was severely contaminated by highbackground. Such objects are thought to be candidates for the progenitorsof type Ia supernovae, or may alternatively undergo accretion-inducedcollapse to form the neutron stars in some millisecond pulsars. Thenature of their short period oscillations remains unknown. The on-axisXMM-Newton observation proposed below would deliver a much improvedspectrum, allowing precise characterisation of the system.

Several supernovae (SNe) with an unusually dense circumstellar medium (CSM) have been recently observed at radio frequencies. Their radio emission is powered by relativistic electrons that can be either accelerated at the SN shock (primaries) or injected as a by-product (secondaries) of inelastic proton-proton collisions. We investigate the radio signatures from secondary electrons, by detailing a semi-analytical model to calculate the temporal evolution of the distributions of protons, primary and secondary electrons. With our formalism, we track the cooling history of all the particles that have been injected into the emission region up to a given time, and calculate the resulting radio spectra and light curves. For an SN shock propagating through the progenitor wind, we find that secondary electrons control the early radio signatures, but their contribution decays faster than that of primary electrons. This results in a flattening of the light curve at a given radio frequency that depends only upon the radial profiles of the CSM density and of the shock velocity, υ0. The relevant transition time at the peak frequency is {∼ } {190} d K_ep,-3^{-1} A_{w, 16}{/β _{0, -1.5}^2}, where Aw is the wind mass-loading parameter, β0 = υ0/c and Kep are the electron-to-proton ratio of accelerated particles. We explicitly show that late peak times at 5 GHz (I.e. tpk ≳ 300-1000 d) suggest a shock wave propagating in a dense wind (Aw ≳ 1016-1017 gr cm-1), where secondary electrons are likely to power the observed peak emission.

The rate of force development (RFD) is an essential component for performance in explosive activities, although it has been proposed that muscle architectural characteristics might be linked with RFD and power performance. The purpose of the study was to investigate the relationship between RFD, muscle architecture, and performance in young track and field throwers. Twelve young track and field throwers completed 10 weeks of periodized training. Before (T1) and after (T2) training performance was evaluated in competitive track and field throws, commonly used shot put tests, isometric leg press RFD, 1 repetition maximum (1RM) strength as well as vastus lateralis architecture and body composition. Performance in competitive track and field throwing and the shot put test from the power position increased by 6.76 ± 4.31% (p < 0.001) and 3.58 ± 4.97% (p = 0.019), respectively. Rate of force development and 1RM strength also increased (p ≤ 0.05). Vastus lateralis thickness and fascicle length increased by 5.95 ± 7.13% (p = 0.012) and 13.41 ± 16.15% (p = 0.016), respectively. Significant correlations were found at T1 and T2, between performance in the shot put tests and both RFD and fascicle length (p ≤ 0.05). Close correlations were found between RFD, muscle thickness, and fascicle length (p ≤ 0.05). Significant correlations were found between the % changes in lean body mass and the % increases in RFD. When calculated together, the % increase in muscle thickness and RFD could predict the % increase in shot put throw test from the power position (p = 0.019). These results suggest that leg press RFD may predict performance in shot put tests that are commonly used by track and field throwers.

The last 3,000 years of relative sea level (RSL) in Israel are derived primarily from archaeological indicators with additional bio-construction indicators (Dendropoma petraeum reefs at the edge of the abrasion platform along the Israeli coast). The current study examines whether sea-level fluctuations (above and mainly below present-day MSL) observed along the coast of Israel can also be observed in other East Mediterranean areas like Greece so that better evaluations can be made of local and regional driving mechanisms. There are three objectives for achieving this goal: 1) Identify new and already published archaeological and biological RSL indicators from this period in Israel and Greece; 2) Assess the reliability of both existing and new indicators using consistent standards to determine which types most accurately indicate ancient RSL and with what degree of uncertainty; 3) Correct the data for isostatic and tectonic effects. The survey collected nearly 140 archaeological indicators from Israel and about 120 from Greece. Of the Israeli indicators, some 120 were deemed reliable enough for reconstructions, whereas in Greece only 40 were, and not all of these from tectonically stable areas. The Israeli data includes 31 dates obtained from Dendropoma reefs in Israel. The higher reliability of the Israeli dataset may stem from a smaller coastline and more focused SL research over the past few decades. In Greece, many measurements were taken before precise surveying methods were available, and published without sufficient metadata. The two regional datasets reveal chronological gaps and disparities: Israel has a strong set of many indicators from the Roman Period (2000BP) to present, but fewer from 3000-2000BP, while Greek indicators are strongly clustered in the Classical to Hellenistic Periods (2500-2000BP). On-going research is focusing now also on the last Millennial Greek sea levels (mainly the ‘Venetian’ period). Results however suggest some correspondence and support previous Israeli conclusions suggesting somewhat lower levels around 2500BP and in the first half of the last Millennium: The Crusader period in Israel (11th to 13th century AD) and the Venetian period in Greece (12th to 15th century AD). Near-present, stable levels are indicated during most other periods, despite indications of slightly higher sea levels in the late Roman/Byzantine period.

Immunoglobulin light chain (AL) amyloidosis, the most common of the systemic amyloidosis, is characterized by the deposition of amyloid fibrils that derive from the aggregation of misfolded monoclonal immunoglobulin light chains. Amyloid fibrils disrupt tissue architecture and the pre-fibril oligomers are directly toxic to myocardiac cells, causing cardiac dysfunction. The lethal consequences of AL amyloidosis are due to the toxic product and not due to the malignant behaviour of the plasma cell clone however, the characteristics of this clone are associated with long-term prognosis. Early and accurate diagnosis is the key to effective management, but is challenging. Modern chemotherapy options (including autologous transplantation, bortezomib, lenalidomide) have improved the outcomes of patients at low or intermediate risk, but the prognosis of patients with severe cardiac dysfunction is still poor. Therapies targeting amyloid deposits and the amyloidogenic process are under investigation and offer promise for better future treatments. © 2016 John Wiley & Sons Ltd.

We present results from the latest outburst of the Be/X-ray binary system SMC X-2, which in late 2015 entered it's first X-ray outburst since 2000. SMC X-2 was first discovered in 1977 by the SAS-3 satellite, and hosts a 2.37s period pulsar. Regular, almost daily, Swift observations of SMC X-2 were performed during the entirety of the latest outburst, from first detection by MAXI to it’s rapid turn off and return back to quiescence. These observations have allowed us to measure with the flux, spectral and temporal properties of SMC X-2. Timing analysis of observation by the Swift X-ray telescope allowed us to track the evolution of the pulsar spin period, and in addition modeling of the orbital parameters of the system by measuring changes in the pulsar spin period due to Doppler effects. In addition we report on an observation of SMC X-2 taken with NuSTAR, which allowed both to better measure the continuum fit above 10 keV, and to perform a sensitive measure of the pulse profile and period of the source.

This document is based on the original recommendation of the Expert Panel on the Theory of Reference Values of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC), updated guidelines were recently published under the auspices of the IFCC and the Clinical and Laboratory Standards Institute (CLSI). This document summarizes proposals for recommendations on: (i) The terminology, which is often confusing, noticeably concerning the terms of reference limits and decision limits. (ii) The method for the determination of reference limits according to the original procedure and the conditions, which should be used. (iii) A simple procedure allowing the medical laboratories to fulfill the requirements of the regulation and standards. The updated document proposes to verify that published reference limits are applicable to the laboratory involved. Finally, the strengths and limits of the revised recommendations (especially the selection of the reference population, the maintenance of the analytical quality, the choice of the statistical method used...) will be briefly discussed

The diagnosis of Waldenström macroglobulinaemia (WM) can be challenging given the variety of signs and symptoms patients can present. Furthermore, once the diagnosis of WM is established, the initial evaluation should be thorough as well as appropriately directed. During the 8th International Workshop for WM in London, United Kingdom, a multi-institutional task force was formed to develop consensus recommendations for the diagnosis and initial evaluation of patients with WM. In this document, we present the results of the deliberations that took place to address these issues. We provide recommendations for history-taking and physical examination, laboratory studies, bone marrow aspiration and biopsy analysis and imaging studies. We also provide guidance on the initial evaluation of special situations, such as anaemia, hyperviscosity, neuropathy, Bing-Neel syndrome and amyloidosis. We hope these recommendations serve as a practical guidance to clinicians taking care of patients with a suspected or an established diagnosis of WM. © 2016 John Wiley & Sons Ltd

The diagnosis of Waldenström macroglobulinaemia (WM) can be challenging given the variety of signs and symptoms patients can present. Furthermore, once the diagnosis of WM is established, the initial evaluation should be thorough as well as appropriately directed. During the 8th International Workshop for WM in London, United Kingdom, a multi-institutional task force was formed to develop consensus recommendations for the diagnosis and initial evaluation of patients with WM. In this document, we present the results of the deliberations that took place to address these issues. We provide recommendations for history-taking and physical examination, laboratory studies, bone marrow aspiration and biopsy analysis and imaging studies. We also provide guidance on the initial evaluation of special situations, such as anaemia, hyperviscosity, neuropathy, Bing-Neel syndrome and amyloidosis. We hope these recommendations serve as a practical guidance to clinicians taking care of patients with a suspected or an established diagnosis of WM. © 2016 John Wiley & Sons Ltd

OBJECTIVE: Although our understanding of viral transmission among people who inject drugs (PWID) has improved, we still know little about when and how many times each injector transmits HIV throughout the duration of infection. We describe HIV dynamics in PWID to evaluate which preventive strategies can be efficient. DESIGN: Due to the notably scarce interventions, HIV-1 spread explosively in Russia and Ukraine in 1990s. By studying this epidemic between 1995 and 2005, we characterized naturally occurring transmission dynamics of HIV among PWID. METHOD: We combined publicly available HIV pol and env sequences with prevalence estimates from Russia and Ukraine under an evolutionary epidemiology framework to characterize HIV transmissibility between PWID. We then constructed compartmental models to simulate HIV spread among PWID. RESULTS: In the absence of interventions, each injector transmits on average to 10 others. Half of the transmissions take place within 1 month after primary infection, suggesting that the epidemic will expand even after blocking all the post-first month transmissions. Primary prevention can realistically target the first month of infection, and we show that it is very efficient to control the spread of HIV-1 in PWID. Treating acutely infected on top of primary prevention is notably effective. CONCLUSION: As a large proportion of transmissions among PWID occur within 1 month after infection, reducing and delaying transmissions through scale-up of harm reduction programmes should always form the backbone of HIV control strategies in PWID. Growing PWID populations in the developing world, where primary prevention is scarce, constitutes a public health time bomb.

We analyzed a large number of focal mechanisms and relocated earthquake hypocenters to investigate the geodynamics of western Greece, the most seismically active part of the Aegean plate-boundary zone. This region was seismically activated multiple times during the last decade, providing a large amount of enhanced quality new information that was obtained by the Hellenic Unified Seismological Network (HUSN). Relocated seismicity appears concentrated above 25 km depth, exhibiting spatial continuity along the convergence boundary andbeing clustered elsewhere. Earthquakes are confined within the accreted sediments escarpment of the down-going African plate against the un-deformed Pindos hinterland. The data arrangement shows that Pindos constitutes a seismic boundary along which large stress heterogeneities occur. Surprisingly, in Cephalonia no seismicity related with the offshore Cephalonia Transform Fault (CTF) is observed. Onshore, N-S crustal extension dominates, while in central and south Peloponnesus the stress field appears rotated by 90°. Shearing-stress obliquity by 30° is indicated along the major strike-slip faults, consistent with clockwise crustal rotation. Within the lower crust, the stress field appears constrained by plate kinematics and the distributed deformation, which guide the geodynamics of the area.Seismic velocity anomalies have been resolved by regional body-wave traveltime tomography applying an iterative tomographic inversion scheme using phase data from more than 5,000 seismic events recorded by the Hellenic Unified Seismological Network (HUSN), analyzed by the Seismological Laboratory of the Universityof Athens. Preliminary 3D tomographic models indicate the presence of gross structures related with Pindus hinterland, the Tethys subduction beneath the Aegean, and shear zones related with the CTF and the Andravida fault. A predominant NE-SW oriented low velocity zone in central Peloponnesus is related with the rotation of the extensional stress field and dextral strike-slip faulting.

Relapsed/refractory multiple myeloma (RRMM) patients have poor overall survival (OS). Pomalidomide plus low-dose dexamethasone (POM + LoDEX) significantly extends OS in RRMM vs. high-dose dexamethasone. Survival of patients with stable disease (SD) was compared to patients with progressive disease (PD) or ≥ partial response (≥PR) at cycles (C) 3, 5, and 7. Among 302 patients randomized to POM + LoDEX, at C3 19.2% achieved ≥ PR, 38.4% SD, and 14.6% PD. Patients with SD at C3 (17.4%) and C5 (13.6%) showed improved responses at C7. Median OS from randomization by response at C3 was 22.4 months for ≥ PR (n = 58, HR 0.66; 95% CI 0.40–1.08, p = 0.0976 vs. SD), 16.2 months for SD (n = 116), and 6.3 months for PD (n = 44, HR 3.43; 95% CI 2.23–5.27, p < 0.0001 vs. SD). Similar patterns were observed for C5 and C7. Results show that POM + LoDEX should be a standard treatment after lenalidomide and bortezomib, including in SD patients. © 2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

Relapsed/refractory multiple myeloma (RRMM) patients have poor overall survival (OS). Pomalidomide plus low-dose dexamethasone (POM + LoDEX) significantly extends OS in RRMM vs. high-dose dexamethasone. Survival of patients with stable disease (SD) was compared to patients with progressive disease (PD) or ≥ partial response (≥PR) at cycles (C) 3, 5, and 7. Among 302 patients randomized to POM + LoDEX, at C3 19.2% achieved ≥ PR, 38.4% SD, and 14.6% PD. Patients with SD at C3 (17.4%) and C5 (13.6%) showed improved responses at C7. Median OS from randomization by response at C3 was 22.4 months for ≥ PR (n = 58, HR 0.66; 95% CI 0.40–1.08, p = 0.0976 vs. SD), 16.2 months for SD (n = 116), and 6.3 months for PD (n = 44, HR 3.43; 95% CI 2.23–5.27, p < 0.0001 vs. SD). Similar patterns were observed for C5 and C7. Results show that POM + LoDEX should be a standard treatment after lenalidomide and bortezomib, including in SD patients. © 2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

Introduction: Patients with multiple myeloma (MM) have an increased risk of venous thromboembolic (VTE) complications. The first reports of high VTE rates date back to 1999 but became more apparent with the introduction of novel agents in the treatment of MM and mostly with immunomodulatory drugs (IMiDs; thalidomide, lenalidomide and pomalidomide). Areas covered: Currently thromboprophylaxis is recommended for patients who receive IMiDs-based regimens and the type of thrombophrophylaxis is based on patient-, disease- and treatment-related risk factors. Making the distinction between the intrinsic risk of thrombosis in MM and the effect of therapy is crucial. The use of aspirin, low molecular weight heparins and warfarin are the recommended drugs but despite their appropriate use the rates of VTE are not completely eliminated. Expert commentary: Research into biomarkers of increased coagulability and their incorporation in risk assessment models could identify patients most likely to benefit from thromboprophylaxis but such models are not widely used in myeloma. © 2016 Informa UK Limited, trading as Taylor & Francis Group.

Introduction: Patients with multiple myeloma (MM) have an increased risk of venous thromboembolic (VTE) complications. The first reports of high VTE rates date back to 1999 but became more apparent with the introduction of novel agents in the treatment of MM and mostly with immunomodulatory drugs (IMiDs; thalidomide, lenalidomide and pomalidomide). Areas covered: Currently thromboprophylaxis is recommended for patients who receive IMiDs-based regimens and the type of thrombophrophylaxis is based on patient-, disease- and treatment-related risk factors. Making the distinction between the intrinsic risk of thrombosis in MM and the effect of therapy is crucial. The use of aspirin, low molecular weight heparins and warfarin are the recommended drugs but despite their appropriate use the rates of VTE are not completely eliminated. Expert commentary: Research into biomarkers of increased coagulability and their incorporation in risk assessment models could identify patients most likely to benefit from thromboprophylaxis but such models are not widely used in myeloma. © 2016 Informa UK Limited, trading as Taylor & Francis Group.

A fully automatic remote telescope and dome control system has been installed at the University of Athens Observatory (UOAO) in August 2012. It was constructed in the Laboratory of Astronomy and Applied Optics of the department and incorporated the already existing automation for observations and data gathering techniques. The system proved to be reliable and functions faultlessly up to date, enabling the astronomers to observe remotely from any place, using the network. The observing nights have been increased significantly after the first year of remote operation, reaching the number of 280 observing nights per year (77% annual usage), half of which are characterized as photometric nights of highest quality. This utility favours long-term monitoring projects of blazars and long periodic variables in general.

During the current historical coincidence, the geostrategic conjunction of Greece-Cyprus- Israel is a reality, in order for the three states to cope in the best possible manner with the contemporary and future challenges in the arena of international and regional relations. Having a common strategic perception of the geopolitical sub-system of the southeastern Mediterranean, Athens, Nicosia and Jerusalem strengthen day by day their political, diplomatic, economic and military relations, aiming at the preservation of stability in the area, against any revisionist factor. For the aforementioned strategic alliance, the discovery, extraction and exploitation of the hydrocarbon neo-reserves within the Greek, Cypriot and Israeli consecutive Exclusive Economic Zones, (EEZs), is the dynamic catalyst that reinforces even further the allied cooperation and effectiveness. Amidst the geopolitical transformation of the wider region of North Africa, Middle and Near East, the construction of the East Mediterranean Pipeline, (East-Med), is a common pursuit of the outmost significance, for the strategic alliance. Indeed, if the East-Med is realized, it will be able to transfer, in the first phase, the Israeli and Cypriot hydrocarbons from the off-shore neo-reserves via Greek sovereign territory and EEZ to Italy and central Europe, signaling EU’s gradual disengagement from the dependence on the Russian natural gas, allowing the EU to make its first steps of energy emancipation. Despite Ankara’s attempt for rapprochement with Jerusalem, the official Israeli position heavily leans towards an Israel-Greek-Cypriot strategic alignment, as Israel’s national security constitute the ultimate long-term priority for Jerusalem. Above all, such a development will upgrade the geopolitical status of all the three states of the strategic alliance in the regional geopolitical as well as the supra-geopolitical system.

The aim of the study was to examine the correlation between muscle morphology and jumping, sprinting, and throwing performance in participants with different power training duration experience. Thirty-six power-trained young men were assigned to 3 groups according to the length of their power training: less experienced (<1 year), moderately experienced (1-3 years), and experienced (4-7 years). All participants performed countermovement and squat jumps, 60-m sprint, and shot throws twice. Lean body mass (LBM) was evaluated with dual-energy x-ray absorptiometry and thigh muscle cross-sectional area (CSA) with anthropometry. The vastus lateralis architecture and fiber type composition were evaluated with ultrasonography and muscle biopsies, respectively. When all subjects were considered as 1 group (n = 36), jumping performance was correlated with LBM, fascicle length, and type II fiber CSA; sprinting performance was correlated with estimated thigh muscle CSA alone; and shot throwing was correlated with LBM and type I, IIA fiber CSA. In the least experienced group, the LBM of the lower extremities was the most significant contributor for power performance, whereas in the moderately experienced group, the LBM, architectural properties, and type II fiber percentage CSA were the most significant contributors. For the experienced group, fascicle length and type II fiber percentage CSA were the most significant factors for power performance. These data suggest that jumping performance is linked with muscle morphology, regardless of strength or power training. The vastus lateralis muscle morphology could only partially explain throwing performance, whereas it cannot predict sprinting performance. Power performance in experienced participants rely more on the quality of the muscle tissue rather than the quantity.

Patients with relapsed and/or refractory multiple myeloma (RRMM) have poor prognosis. The STRATUS study assessed safety and efficacy of pomalidomide plus low-dose dexamethasone in the largest cohort to date of patients with RRMM. Patients who failed treatment with bortezomib and lenalidomide and had adequate prior alkylator therapy were eligible. Pomalidomide 4 mg was given on days 1-21 of 28-day cycles with low-dose dexamethasone 40 mg (20 mg for patients aged >75 years) on days 1, 8, 15, and 22 until progressive disease or unacceptable toxicity. Safety was the primary end point; secondary end points included overall response rate (ORR), duration of response (DOR), progression-free survival (PFS), and overall survival (OS). Among 682 patients enrolled, median age was 66 years, and median time since diagnosis was 5.3 years. Median number of prior regimens was 5. Most patients were refractory to both lenalidomide and bortezomib (80.2%). Median follow-up was 16.8 months; median duration of treatment was 4.9 months. Most frequent grade 3/4 treatment-emergent adverse events were hematologic (neutropenia [49.7%], anemia [33.0%], and thrombocytopenia [24.1%]). Most common grade 3/4 nonhematologic toxicities were pneumonia (10.9%) and fatigue (5.9%). Grade 3/4 venous thromboembolism and peripheral neuropathy were rare (1.6% each). The ORR was 32.6%, and the median DOR was 7.4 months. Median PFS and OS were 4.6 months and 11.9 months, respectively. We present the largest trial to date evaluating pomalidomide plus low-dose dexamethasone in patients with RRMM, further confirming that this regimen offers clinically meaningful benefit and is generally well tolerated. www.Clinicaltrials.gov identifier NCT01712789. © 2016 by The American Society of Hematology.

Patients with relapsed and/or refractory multiple myeloma (RRMM) have poor prognosis. The STRATUS study assessed safety and efficacy of pomalidomide plus low-dose dexamethasone in the largest cohort to date of patients with RRMM. Patients who failed treatment with bortezomib and lenalidomide and had adequate prior alkylator therapy were eligible. Pomalidomide 4 mg was given on days 1-21 of 28-day cycles with low-dose dexamethasone 40 mg (20 mg for patients aged >75 years) on days 1, 8, 15, and 22 until progressive disease or unacceptable toxicity. Safety was the primary end point; secondary end points included overall response rate (ORR), duration of response (DOR), progression-free survival (PFS), and overall survival (OS). Among 682 patients enrolled, median age was 66 years, and median time since diagnosis was 5.3 years. Median number of prior regimens was 5. Most patients were refractory to both lenalidomide and bortezomib (80.2%). Median follow-up was 16.8 months; median duration of treatment was 4.9 months. Most frequent grade 3/4 treatment-emergent adverse events were hematologic (neutropenia [49.7%], anemia [33.0%], and thrombocytopenia [24.1%]). Most common grade 3/4 nonhematologic toxicities were pneumonia (10.9%) and fatigue (5.9%). Grade 3/4 venous thromboembolism and peripheral neuropathy were rare (1.6% each). The ORR was 32.6%, and the median DOR was 7.4 months. Median PFS and OS were 4.6 months and 11.9 months, respectively. We present the largest trial to date evaluating pomalidomide plus low-dose dexamethasone in patients with RRMM, further confirming that this regimen offers clinically meaningful benefit and is generally well tolerated. www.Clinicaltrials.gov identifier NCT01712789. © 2016 by The American Society of Hematology.

Micro-Abstract We characterized the feasibility and toxicity profile of anthracycline-containing adjuvant chemotherapy in women >65 years of age with early breast cancer. Elderly breast cancer patients derive clinical benefit comparable with that of younger patients, mainly at the cost of increased risk of hematological toxicity. © 2015 Elsevier Inc.

Micro-Abstract We characterized the feasibility and toxicity profile of anthracycline-containing adjuvant chemotherapy in women >65 years of age with early breast cancer. Elderly breast cancer patients derive clinical benefit comparable with that of younger patients, mainly at the cost of increased risk of hematological toxicity. © 2015 Elsevier Inc.

Histone acetyltransferases and histone deacetylases (HDACs) are multifunctional enzymes that posttranslationally modify both histone and nonhistone acetylation sites, affecting a broad range of cellular processes (e.g., cell cycle, apoptosis, and protein folding) often dysregulated in cancer. HDAC inhibitors are small molecules that directly interact with HDAC catalytic sites preventing the removal of acetyl groups, thereby counteracting the effects of HDACs. Since the first HDAC inhibitor, valproic acid, was investigated as a potential antitumor agent, there have been a number of other HDAC inhibitors developed to improve efficacy and safety. Despite significant progress in the management of patients with hematologic malignancies, overall survival is still poor. The discovery that HDACs may play a role in hematologic malignancies and preclinical studies showing promising activity with HDAC inhibitors in various tumor types, led to clinical evaluation of HDAC inhibitors as potential treatment options for patients with advanced hematologic malignancies. The Food and Drug Administration has approved two HDAC inhibitors, vorinostat (2006) and romidepsin (2009), for the treatment of cutaneous T-cell lymphoma. This review highlights the safety of HDAC inhibitors currently approved or being investigated for the treatment of hematologic malignancies, with a specific focus on the safety experience with vorinostat in cutaneous T-cell lymphoma. © 2016.

We analyse the light curve in the R band of the blazar OJ287, gathered during the 2015/2016 observing season. We did a search for quasi-periodic oscillations (QPOs) using several methods over a wide range of timescales. No statistically significant periods were found in the high-frequency domain both in the ground-based data and in Kepler observations. In the longer-period domain, the Lomb-Scargle periodogram revealed several peaks above the 99% significance level. The longest one—about 95 days—corresponds to the innermost stable circular orbit (ISCO) period of the more massive black hole. The 43-day period could be an alias, or it can be attributed to accretion in the form of a two-armed spiral wave.

{The objective of this study is the analysis of heavy precipitation events occurred in Attica region during the period 2007-2013, along with the determination of their characteristics depending on the season and their corresponding impact. These events were selected according to two criteria; the lightning occurrence-information that was acquired from the Hellenic National Meteorological Service Precision Lightning Sensors Network (HNMS-PLN)-and the high rainfall intensity, provided by the Hydrological Observatory of Athens (HOA) rainfall network. On the one hand, the composite means and anomalies of the respective synoptic conditions, which were based on the reanalysis data sets acquired from the National Centers for Environmental Prediction-National Center for Atmospheric Research (NCEP-NCAR), along with the frontal activity over Greece, have been analyzed. On the other hand, special attention has been given to the configuration of specific instability indices, during the examined rainfall events. The aforementioned study is an effort to shed light to the rainfall events' features, with respect to their seasonal incidence and their relation to phenomena such as floods and hail.}

Damage scenarios are necessary tools for stakeholders, in order to prepare protection strategies and a total emergency post-earthquake plan. To this aim, four seismic hazard models were developed for the city of Kalamata, according to stochastic simulation of the ground motion, using site amplification functions derived from ambient noise HVSR measurements. The structural vulnerability of the city was assessed following an empirical macroseismic model, developed for the European urban environment (EMS-98). The impact of the vulnerability due to the seismic hazard potential is also investigated by means of synthetic response spectral ratios at 108 sites of the city. The expected damage grade per building block, is calculated by combining vulnerability with the respective seismic intensities, derived for the four seismic sources. The importance of the followed methodology for implementing microzonation studies is emphasized, since the expected influence of the ground motion amplification due to local soil conditions has been approximated in detail. Moreover, new fragility curves for the main structural types in Kalamata are proposed for each seismic scenario.

A catalogue of relocated earthquake hypocenters and focal mechanisms was constructed and evaluated in order to examine the tectonics of the western Hellenic Arc. The major part of the analysed dataset includes seismic activity that was recorded during the last decade. This is due to the occurrence of several moderate to strong earthquakes in the area and to the integration of the Hellenic Unified Seismological Network (HUSN), which provided adequate coverage with high quality waveform records that were analyzed by the Seismological Laboratory ofthe University of Athens. Additionally, phase data available by local networks were employed. The concept of double differences was applied to achieve improved relative hypocentral locations. Relocated seismicity appears concentrated at depths above 25 km, exhibiting spatial continuity along the convergence boundary and being clustered elsewhere. Earthquakes are confined within the accreted sediments escarpment of the down-going African plate against the un-deformed Pindos hinterland.Stress tensor inversion of ~2000 relocated focal mechanisms reveals predominantly strike-slip faulting in NNE-SSW to NE-SW direction and normal faulting in E-W or N-S directions. The heterogeneity of the stress field appears to be unusually high, particularly in the region of the northernmost tip of the Hellenic subduction and in thevicinity of the Cephalonia-Lefkada transform fault zone, an area of high seismic risk that was activated recently, with the generation of two strong earthquakes of Mw=6.1 and 5.9 at the western part of the Cephalonia Island in January-February 2014 and an Mw=6.4 event that occurred onshore SW Lefkada Island in November 2015. The stress field distribution implies that Pindos constitutes a seismic boundary along which large heterogeneities occur. Onshore western Greece, N-S crustal extension dominates, while in central and south Peloponnesus the stress field appears rotated by 90°. Shearing-stress obliquity by 30° is indicated along the major strike-slip faults. At larger depths, within the lower crust, the stress field becomes more homogeneous, consistent with well-known large scale kinematics of the Aegean region.

Multiple myeloma (MM) is a multi-subclonal malignancy with relatively high heterogeneity. Patients who initially presented with both monoclonal-protein (MP) and free light chain (FLC) secretion but then relapsed with a light chain escape pattern have been shown to reflect disease clonal evolution and to bare a worse prognosis. We hypothesized that a discordant MP/FLC pattern at diagnosis may reflect a similar clonal evolution that had occurred prior to diagnosis of active myeloma, conferring a worse outcome. We analyzed 255 consecutive newly diagnosed MM patients who received first line bortezomib-based therapy between 2007 and 2014, hypothesizing that their MP/FLC fingerprint at diagnosis reflects clonal heterogeneity and, therefore, affects outcome. An involved FLC level ≥ 700 mg/L and MP ≥ 2.5 g/L were used as cutoffs for low vs high FLC and MP levels, respectively. Patients were divided into 4 subgroups according to their involved FLC and MP blood levels at diagnosis: HiLC and HiMP for patients with either a predominant FLC or a predominant MP, respectively, and HiLC-MP and LoLC-MP when both FLC and MP were increased or decreased, respectively. There were 68 (27%) patients with HiLC, which presented more often with International Staging System-3 stage (P < .0001). Multivariate analysis showed that HiLC was associated with a 5.1-fold risk for mortality in a multivariate model (95% confidence interval [CI], 1.34-19.68). Both HiLC and HiLC-MP phenotypes were associated with shorter progression-free survival (hazard ratio of 2.66 [95% CI, 1.33-5.32] and 2.82 [95% CI, 1.37-5.83], respectively), independently of other prognostic factors, including the use of autograft. Thus, we identified an LC predominant secretory fingerprint (HiLC phenotype) at diagnosis as a potential independent risk factor that may affect disease control and survival in newly diagnosed MM patients treated with bortezomib-based induction therapy; this may represent increased subclonal heterogeneity. © 2016 John Wiley & Sons, Ltd.

SUMMARY: The purpose of the present study is to define which regions of the cranium, the upper-face, the orbits and the nasal are the most sexually dimorphic, by using three-dimensional geometric morphometric methods, and investigate the effectiveness of this method in determining sex from the shape of these regions. The study sample consisted of 176 crania of known sex (94 males, 82 females) belonging to individuals who lived in Greece during the 20(th) century. The three-dimensional co-ordinates of 31 ecto-cranial landmarks were digitized using a MicroScribe 3DX contact digitizer. Goodall's F-test was performed in order to compare statistical differences in shape between males and females. Generalized Procrustes Analysis (GPA) was used to obtain size and shape variables for statistical analysis. Shape, Size and Form analyses were carried out by logistic regression and discriminant function analysis. The results indicate that there are shape differences between the sexes in the upper-face and the orbits. The highest shape classification rate was obtained from the upper-face region. The centroid size of the caraniofacial and the orbital regions was smaller in females than males. Moreover, it was found that size is significant for sexual dimorphism in the upper-face region. As anticipated, the classification accuracy improves when both size and shape are combined. The findings presented here constitute a firm basis upon which further research can be conducted.

The aim of this study is to assess sexual dimorphism of adult crania in the vault and midsagittal curve of the vault using three-dimensional geometric morphometric methods. The study sample consisted of 176 crania of known sex (94 males, 82 females) belonging to individuals who lived during the 20th century in Greece. The three-dimensional co-ordinates of 31 ecto-cranial landmarks and 30 semi-landmarks were digitized using a MicroScribe 3DX contact digitizer. Generalized Procrustes analysis (GPA) was used to obtain size and shape variables for statistical analysis. Shape, size and form analyses were carried out by logistic regression and three discriminant function analyses. Results indicate that there are shape differences between sexes. Females in the region of the parietal bones are narrower and the axis forming the frontal and occipital bones is more elongated; the frontal bone is more vertical. Sex-specific shape differences give better classification results in the vault (79%) compared with the midsagittal curve of the neurocranium (68.8%). Size alone yielded better results for cranial vault (82%), while for the midsagittal curve of the vault the result is poorer (68.1%). As anticipated, the classification accuracy improves when both size and shape are combined (89.2% for vault, and 79.4% for midsagittal curve of the vault). These latter findings imply that, in contrast to the midsagittal curve of the neurocranium, the shape of the cranial vault can be used as an indicator of sex in the modern Greek population.

OBJECTIVES: This study aimed to quantify the patterns of shape variability and the extent and patterns of shape covariation between the upper and lower dental arch in an orthodontic population. METHODS: Dental casts of 133 white subjects (61 males, 72 females; ages 10.6-26.6) were scanned and digitized in three dimensions. Landmarks were placed on the incisal margins and on the cusps of canines, premolars, and molars. Geometric morphometric methods were applied (Procrustes superimposition and principal component analysis). Sexual dimorphism and allometry were evaluated with permutation tests and age-size and age-shape correlations were computed. Two-block partial least squares analysis was used to assess covariation of shape. RESULTS: The first four principal components represented shape patterns that are often encountered and recognized in clinical practice, accounting for 6-31 per cent of total variance. No shape sexual dimorphism was found, nevertheless, there was statistically significant size difference between males and females. Allometry was statistically significant, but low (upper: R(2) = 0.0528, P < 0.000, lower: R (2) = 0.0587, P < 0.000). Age and shape were weakly correlated (upper: R(2) = 0.0370, P = 0.0001, lower: R (2) = 0.0587, P = 0.0046). Upper and lower arches covaried significantly (RV coefficient: 33 per cent). The main pattern of covariation between the dental arches was arch width (80 per cent of total covariance); the second component related the maxillary canine vertical position to the mandibular canine labiolingual position (11 per cent of total covariance). LIMITATIONS: Results may not be applicable to the general population. Age range was wide and age-related findings are limited by the cross-sectional design. Aetiology of malocclusion was also not considered. CONCLUSIONS: Covariation patterns showed that the dental arches were integrated in width and depth. Integration in the vertical dimension was weak, mainly restricted to maxillary canine position.

The long term change of the shoreline is a phenomenon, which is factored in the design of construction projects along the coastal zone. This study presents a meth-odology that aims to quantify the shoreline displacement rate. The described meth-odology involves the interpretation of different remote sensing data types, which make up a quite dense time series of representations for the coastline spanning from 1987 to 2012. The representation of the shoreline is based on geometrically corrected (ortho-rectified), historical, analogue, panchromatic, high resolution aerial photos of the area (1987, 1996) and latest generation, digital, multispectral, high resolution satellite images (2000, 2008, 2012). In all cases the images were digitally processed and optically optimized in order to produce a highly accurate representation of the shoreline in each time period. All the data were imported in a Geographic Information System platform, where they were subjected to comparison and geo-statistical analysis. A large number of sections perpendicular to the coast (every 100 meters) was drawn and the relative motion of the coastline was calcu-lated for each of them. The average rate of the calculated erosion is in the order of 24mm/year whilst extreme rates of 1m/year were also observed in specific posi-tions.

A thorough study of localized surface plasmons and associated strong circular dichroism, which can occur in silver-coated metallic and dielectric magnetic nanospheres, is reported by means of both quasistatic and full electrodynamic calculations taking into account the actual (magneto) optical response of the constituent materials, including dispersion and losses. It is shown that such composite magnetoplasmonic nanoparticles offer a versatile platform for engineering hybrid plasmon modes that give rise to sharp absorption resonances and subject to large magneto-optic splitting, leading to giant magnetic circular dichroism signals, by properly choosing the different materials and tuning the geometrical parameters involved.

The objective of this paper was to explore whether and how the main capital structure determinants of SMEs affected capital structure determination in different ways during the years of economic crisis. We used panel data of 8,052 SMEs operating in Greece during 2009–2012. We found that the effect of capital structure determinants on leverage does not change in an environment of economic crisis; larger SMEs continued to show higher debt ratios, the relationship between profitability and tangibility of assets with leverage continued to be negative, and growth was positively related to leverage.

Ιn a sample of Turkish adolescents (N = 1614), we investigated whether pursuing social demonstration-approach goals (to attain popularity), next to social development goals (to cultivate meaningful relationships), explains differences in need satisfaction and frustration and coping. Cluster analysis showed that students who favored social development over social demonstration-approach goals reported less need frustration and defensive coping than students who favored both goals. These results were replicated with a prospective analysis with part of the initial sample (N = 425) as students who endorsed both goals reported more defensive coping five months later than students who mainly favored social development goals over social demonstration-approach goals.

BACKGROUND AND AIMS: Over the past two decades there was an upsurge of the use of Internet in human life. With this continuous development, Internet users are able to communicate with any part of the globe, to shop online, to use it as a mean of education, to work remotely and to conduct financial transactions. Unfortunately, this rapid development of the Internet has a detrimental impact in our life, which leads to various phenomena such as cyber bullying, cyber porn, cyber suicide, Internet addiction, social isolation, cyber racism etc. The main purpose of this paper is to record and analyze all these social and psychological effects that appears to users due to the extensive use of the Internet. MATERIALS AND METHODS: This review study was a thorough search of bibliography data conducted through Internet and library research studies. Key words were extracted from search engines and data bases including Google, Yahoo, Scholar Google, PubMed. FINDINGS: The findings of this study showed that the Internet offers a quick access to information and facilitates communication however; it is quite dangerous, especially for young users. For this reason, users should be aware of it and face critically any information that is handed from the website.

Published archaeological, palaeoenvironmental, and palaeoclimatic data from the Peloponnese in Greece are compiled, discussed and evaluated in order to analyse the interactions between humans and the environment over the last 9000 years. Our study indicates that the number of human settlements found scattered over the peninsula have quadrupled from the prehistoric to historical periods and that this evolution occurred over periods of climate change and seismo–tectonic activity. We show that societal development occurs both during periods of harsh as well as favourable climatic conditions. At some times, some settlements develop while others decline. Well-known climate events such as the 4.2 ka and 3.2 ka events are recognizable in some of the palaeoclimatic records and a regional decline in the number and sizes of settlements occurs roughly at the same time, but their precise chronological fit with the archaeological record remains uncertain. Local socio-political processes were probably always the key drivers behind the diverse strategies that human societies took in times of changing climate. The study thus reveals considerable chronological parallels between societal development and palaeoenvironmental records, but also demonstrates the ambiguities in these correspondences and, in doing so, highlights some of the challenges that will face future interdisciplinary projects. We suggest that there can be no general association made between societal expansion phases and periods of advantageous climate. We also propose that the relevance of climatic and environmental regionality, as well as any potential impacts of seismo-tectonics on societal development, need to be part of the interpretative frameworks.

Основание НАТО 4 апреля 1949 года драматическим образом ознаменовало окончательный распад альянса трех великих держав - США, Великобритании и СССР, созданного во время Второй мировой войны. Вместе с тем, это стало началом новой, послевоенной биполярной системе баланса сил, главным проявлением которой стала Холодная война. Это тотальное политическое противостояние между двумя сверхдержавами и их сателлитами, распространившееся на большую часть нашей планеты, началось на послевоенных руинах Старого Света, где столкнулись исторически противоположные геополитические устремления обеих сторон - противостояние, усиленное ростом числа откровенных мистификаций, скрытые мотивов и стереотипов, а также конфликтом национальных интересов. В фундаменте этого противостояния лежат принципы и ценности, с 1945 года взятые Уставом ООН в качестве основы для создания послевоенной международной системы. Главные пункты этого Устава объявляют применение насилия в международных отношениях как способ разрешения международных споров нелегитимным (статьи 2.3 и 2.4), обязывают уважать внутренние дела государства (статья 2.7), а также определяют право государств на индивидуальную или коллективную самооборону (как «соПейме зе!^-сЫепсе») - это определяется в статье 21 Устава ООН (а также, позже, в статье 5 Устава НАТО, и в соответствующих статьях Варшавского договора). Задуманное, как это часто бывает, с благими намерениями, в конце концов все это превратилось в гигантский ком неуверенности, страха и взаимного недоверия, а порой и открытой ненависти с обеих сторон. Первым последствием стало разделение Германии, что придало последующему разделению Европы «официальный». Это стало знаковым событием, обнажившим конфликт интересов между Западом и СССР - блокада Берлина советскими войсками (19481949), после чего было создано НАТО.

Ugo Foscolo, was an Italian poet whose works rank among the masterpieces of Italian literature. Talented and well educated in philosophy, classics, and Italian literature, Foscolo gave literary expression to his ideological aspirations and to the numerous amorous experiences in odes, sonnets, plays, poems and an epistolary novel. Concurrent with his rich literary output, Foscolo’s correspondence represents a unique perspective from which to monitor his literary and political views and investigate aspects of his everyday life. Among other interesting information, one can find elements of Foscolo’s medical history which is generally unknown. In the present article we investigate the possibility that chronic bladder outlet obstruction and the consequent renal insufficiency was attributed to the death of Ugo Foscolo.

Προσκεκλημένη-συμμετοχή στην Ημερίδα Meet up – Κοινωνική Επιχειρηματικότητα Συμβουλές & Σύμβουλοι. «Διαδραστική Συνάντηση Ενδυνάμωσης Δεξιοτήτων». Europe Direct City of Athens, Sesbo-social enterprise skills, IKY,  Funded by Erasmus+ Programme of the European Union, Αθήνα, 25 Οκτωβρίου 2016.

Στον ελληνικό περιοδικό τύπο του 19ου αιώνα κυριαρχεί η αρθρογραφία για την Ελληνική αρχαιότητα αντανακλώντας το φλέγον ζητούμενο της εποχής, τη σύνδεση του νεώτερου Ελληνισμού με την ελληνική αρχαιότητα, με σκοπό την δημιουργία μιας εθνικής ταυτότητας, την πολυπόθητη διαμόρφωση της εθνικής συνείδησης, συνυφασμένη με τον ευρωπαϊσμό. Η ελληνική αρχαιότητα αποκαλύπτεται στους φιλομαθείς του νεοσύστατου κρατιδίου μέσα από τις μεταφράσεις άρθρων των αρχαιολατρών μελετητών της Δύσης. Ήδη από τα μέσα του 18ου αι. η δυτική αρχαιοφιλία απασχολείται συστηματικά με όλες τις εκφάνσεις του αρχαιοελληνικού πολιτισμού, τις οποίες –ως επακόλουθο- ενσωματώνει στη σύγχρονη ευρωπαϊκή σκέψη και πνευματική δημιουργία, παράγοντας διακείμενα σε όλους τους τομείς των γραμμάτων και των τεχνών (φιλοσοφία, λογοτεχνία, θέατρο, μουσική, καλές τέχνες, αρχιτεκτονική). Το άρθρο πραγματεύεται μία δημοσίευση στην Ιωνική Μέλισσα στις 16/11/1850, το οποίο τιτλοφορείται «Οιδίπους Τύραννος» και υπογράφεται από τον «Πείσανδρο», πιθανό ψευδώνυμο –δίχως να έχει επιβεβαιωθεί η πληροφορία- του Ικέσιου Λάτρη (1799 - 1881), Σμυρναίου λόγιου, αγωνιστή του 1821 και πολιτικού της νεοσύστατης Ελλάδας. Στο εν λόγω άρθρο, το οποίο αναφέρεται στα θέματα της πρόσληψης του αρχαίου θεάτρου, αναπτύσσεται ένας πρώιμος προβληματισμός, για τον οποίον όμως προτάσσονται λύσεις και περιγράφεται ο τρόπος υλοποίησης μίας πολιτικής στρατηγικής.

Talented and well educated in philosophy, classics and Italian literature, Foscolo gave literary expression to his ideological aspirations and to his numerous amorous experiences in odes, sonnets, plays, poems and an epistolary novel. Concurrent with his rich literary output, Foscolo's correspondence represents a unique perspective from which to monitor his literary and political views and investigate aspects of his everyday life. Among other interesting information, one can find elements of Foscolo medical history which is generally unknown. In the present article we investigate the longstanding lower urinary tract symptoms as reported by the poet in his correspondence to his family and friends.

We analyzed a large number of focal mechanisms and relocated earthquake hypocenters to investigate the geodynamics of western Greece, the most seismically active part of the Aegean plate-boundary zone. This region was seismically activated multiple times during the last decade, providing a large amount of enhanced quality new information that was obtained by the Hellenic Unified Seismological Network (HUSN). Relocated seismicity using a double-difference method appears to be concentrated above ∼35 km depth, exhibiting spatial continuity along the convergence boundary and being clustered elsewhere. Earthquakes are confined within the accreted sediments escarpment of the down-going African plate against the un-deformed Eurasian hinterland. The data arrangement shows that Pindos constitutes a seismic boundary along which large stress heterogeneities occur. In Cephalonia no seismicity is found to be related with the offshore Cephalonia Transform Fault (CTF). Onshore, NS crustal extension dominates, while in central and south Peloponnesus the stress field appears rotated by 90°. Shearing-stress obliquity by 30° is indicated along the major strike-slip faults, consistent with clockwise crustal rotation. Within the lower crust, the stress field appears affected by plate kinematics and distributed deformation of the lower crust and upper mantle, which guide the regional geodynamics.

Using the Boltzmann formalism based on the first principles electronic structure and scattering rates, we investigate the current-induced spin accumulation and spin-orbit torques in FePt/Pt and Co/Cu bilayers in the presence of substitutional impurities. In FePt/Pt bilayers we consider the effect of intermixing of Fe and Pt atoms in the FePt layer and find a crucial dependence of spin accumulation and spin-orbit torques on the details of the distribution of these defects. In Co/Cu bilayers we predict that the magnitude and sign of the spin-orbit torque and spin accumulation depend very sensitively on the type of the impurities used to dope the Cu substrate. Moreover, simultaneously with impurity-driven scattering, we consider the effect of an additional constant quasiparticle broadening of the states at the Fermi surface to simulate phonon scattering at room temperature and discover that even a small broadening of the order of 25 meV can drastically influence the magnitude of the considered effects. We explain our findings based on the analysis of the complex interplay of several competing Fermi surface contributions to the spin accumulation and spin-orbit torques in these structurally and chemically nonuniform systems.

We explain and motivate Stefan–Sussmann singular foliations, and by replacing the tangent bundle of a manifold with an arbitrary Lie algebroid, we introduce singular subalgebroids. Both notions are defined using compactly supported sections. The main results of this note are an equivalent characterization, in which the compact support condition is removed, and an explicit description of the sheaf associated to any Stefan–Sussmann singular foliation or singular subalgebroid.

The synthesis and molecular structures of a U(v) neutral terminal oxo complex and a U(v) sodium uranium nitride contact ion pair are described. The synthesis of the former is achieved by the use of tBuNCO as a mild oxygen transfer reagent, whilst that of the latter is via the reduction of NaN3. Both mono-uranium complexes are stabilised by the presence of bulky silyl substituents on the ligand framework that facilitate a 2e- oxidation of a single U(iii) centre. In contrast, when steric hindrance around the metal centre is reduced by the use of less bulky silyl groups, the products are di-uranium, U(iv) bridging oxo and (anionic) nitride complexes, resulting from 1e- oxidations of two U(iii) centres. SQUID magnetometry supports the formal oxidation states of the reported complexes. Electrochemical studies show that the U(v) terminal oxo complex can be reduced and the [U(iv)O]- anion was accessed via reduction with K/Hg, and structurally characterised. Both the nitride complexes display complex electrochemical behaviour but each exhibits a quasi-reversible oxidation at ca. -1.6 V vs. Fc+/0.

We consider a fluid queue with two modes of service, that represents a production facility, where the processing of the customers (units) is typically carried out at a much faster time-scale than the machine-related processes. We examine the strategic behavior of the customers, regarding the joining/balking dilemma, under two levels of information upon arrival. Specifically, just after arriving and before making the decision, a customer observes the level of the fluid, but may or may not get informed about the state of the server (fast/slow). Assuming that the customers evaluate their utilities based on a natural reward/cost structure, which incorporates their desire for processing and their unwillingness to wait, we derive symmetric equilibrium strategy profiles. Moreover, we illustrate various effects of the information level on the strategic behavior of the customers. The corresponding social optimization problem is also studied and the inefficiency of the equilibrium strategies is quantified via the Price of Anarchy (PoA) measure.

This article explores patterns of accentuation that are profoundly af- fected by the morphosyntactic structure and, especially, by the way the constituents of a word are assembled and concomitantly processed by the PF component. We first review well-known cases of stress-affecting affixation in English from various theoretical perspectives in order to discover key aspects of the architectural and/or lexical item-specific conditions that instigate accentual dominance, that is, the attraction of stress by certain morphological constituents. We propose a path of analysis along the lines of Embick’s (2014) phase-based approach to the morphosyntax/phonology interface, according to which the ability of the exponent of a morpheme to trigger a cyclic phonological rule (phonological cyclicity) is dissociated from the phase status of the morpheme (phase cyclicity) and becomes an unpredictable property of its exponent. Based on an examination of the more intricate pat- terns of accentual dominance exhibited by a group of lexical stress systems—namely Greek, Vedic Sanskrit and Yakima Sahaptin—we propose that dominance emanates from both the architectural properties of the Grammar and the idiosyncratic lexical properties of the exponents of the morphosyntactic constituents, but not in a totally arbitrary way as predicted by Embick’s approach. Notably, our study reveals that a set of significant, so far unnoticed, implicational relations between phasehood and phonological cyclicity apply: No system has dominant exponents of non-phase heads without having dominant exponents of phase heads; and, moreover, no system has dominant accentless exponents without having dominant accented ones.

Although its involvement in prion replication and neurotoxicity during transmissible spongiform encephalopathies is undisputed, the physiological role of the cellular prion protein (PrP(C)) remains enigmatic. A plethora of functions have been ascribed to PrP(C) based on phenotypes of Prnp(-/-) mice. However, all currently available Prnp(-/-) lines were generated in embryonic stem cells from the 129 strain of the laboratory mouse and mostly crossed to non-129 strains. Therefore, Prnp-linked loci polymorphic between 129 and the backcrossing strain resulted in systematic genetic confounders and led to erroneous conclusions. We used TALEN-mediated genome editing in fertilized mouse oocytes to create the Zurich-3 (ZH3) Prnp-ablated allele on a pure C57BL/6J genetic background. Genomic, transcriptional, and phenotypic characterization of Prnp(ZH3/ZH3) mice failed to identify phenotypes previously described in non-co-isogenic Prnp(-/-) mice. However, aged Prnp(ZH3/ZH3) mice developed a chronic demyelinating peripheral neuropathy, confirming the crucial involvement of PrP(C) in peripheral myelin maintenance. This new line represents a rigorous genetic resource for studying the role of PrP(C) in physiology and disease.

We have continued monitoring the blazar OJ287 in the optical at several sites after its November/December, 2015 outburst. After a further large outburst that started in the beginning of February, 2016 (Atels #8667, #8697, #8705) OJ287 remained brighter than 14th magnitude [in R] for the rest of the month.

Spin dephasing by the Dyakonov-Perel mechanism in metallic films deposited on insulating substrates is revealed, and quantitatively examined by means of density functional calculations combined with a kinetic equation. The surface-to-substrate asymmetry, probed by the metal wave functions in thin films, is found to produce strong spin-orbit fields and a fast Larmor precession, giving a dominant contribution to spin decay over the Elliott-Yafet spin relaxation up to a thickness of 70 nm. The spin dephasing is oscillatory in time with a rapid (subpicosecond) initial decay. However, parts of the Fermi surface act as spin traps, causing a persistent tail signal lasting 1000 times longer than the initial decay time. It is also found that the decay depends on the direction of the initial spin polarization, resulting in a spin-dephasing anisotropy of 200% in the examined cases.

The methodological foundations of mainstream economics have been cited as one of the main reasons for its failure to account for the economic crisis of 2008. In spite of this, the status of economic methodology has not been elevated. It is argued that this is due to the persistent aversion towards methodological discourse by most mainstream economists. This attitude has a long presence as exemplified in Frank Hahn’s (1992) work. After focusing on the debate originating after the publication of Hahn’s arguments, the paper offers a categorization of the main explanations for mainstream methodological aversion. Subsequently, it suggests an explanation based on the role of the physics scientific ideal, arguing that the endeavour to achieve the high scientific status of physics by following the methods of physics, contributed to the negative mainstream attitude towards economic methodology. The relevant writings of the extremely influential mainstream economists Irwin Fisher and Milton Friedman, reinforce the assertion that the alleged hard science status of economics renders methodological discussions and especially methodological criticism, rather pointless. The paper also calls for a more systematic discussion of this issue, especially in the wake of the line of argument that links the recent failings of mainstream to its methodological basis