Publications

We investigated the phase behavior of thin film, thickness h  100 nm, mixtures of a polystyrene-b-poly(2-vinylpyridine) (PS-b-P2VP) diblock copolymer with star-shaped polystyrene (SPS) molecules of varying functionalities f, where 4 < f < 64, and molecular weights per arm Marm. The miscibility of the system and the surface composition varied appreciably with Marm and f. For large values of Marm, regardless of f, the miscibility of the system was qualitatively similar to that of linear chain PS/PS-b-P2VP mixtures – the copolymer chains aggregate to form micelles, each composed of an inner P2VP core and PS corona, which preferentially segregate to the free surface. On the other hand, for large f and small Marm, SPS molecules preferentially resided at the free surface. Moreover, blends containing SPS molecules with the highest values of f and lowest values of Marm were phase separated. These observations are rationalized in terms of competing entropic interactions and the dependence of the surface tension of the star shaped molecules on Marm and f.

An extension of the layer-multiple-scattering method to phononic crystals of poroelastic spheres immersed in a fluid medium is developed. The applicability of the method is demonstrated on specific examples of close-packed fcc crystals of submerged water-saturated meso- and macroporous silica microspheres. It is shown that, by varying the pore size and/or the porosity, the transmission, reflection, and absorption spectra of finite slabs of these crystals are significantly altered. Strong absorption, driven by the slow waves in the poroelastic material and enhanced by multiple scattering, leads to negligible transmittance over an extended frequency range, which might be useful for practical applications in broadband acoustic shielding. The results are analyzed by reference to relevant phononic dispersion diagrams in the viscous and inertial coupling limits, and a consistent interpretation of the underlying physics is provided.

In this paper, we present a combined photometric, spectroscopic, and orbital period study of three early-type eclipsing binary systems: XZ Aql, UX Her, and AT Peg. As a result, we have derived the absolute parameters of their components and, on that basis, we discuss their evolutionary states. Furthermore, we compare their parameters with those of other binary systems and with theoretical models. An analysis of all available up-to-date times of minima indicated that all three systems studied here show cyclic orbital changes; their origin is discussed in detail. Finally, we performed a frequency analysis for possible pulsational behavior, and as a result we suggest that XZ Aql hosts a δ Scuti component.

Blobs, or quasi-spherical emission regions containing relativistic particles and magnetic fields, are often assumed ad hoc in emission models of relativistic astrophysical jets, yet their physical origin is still not well understood. Here, we employ a suite of large-scale 2D particle-in-cell simulations in electron-positron plasmas to demonstrate that relativistic magnetic reconnection can naturally account for the formation of quasi-spherical plasmoids filled with high-energy particles and magnetic fields. Our simulations extend to unprecedentedly long temporal and spatial scales, so we can capture the asymptotic physics independently of the initial setup. We characterize the properties of the plasmoids, continuously generated as a self-consistent by-product of the reconnection process: they are in rough energy equipartition between particles and magnetic fields; the upper energy cutoff of the plasmoid particle spectrum is proportional to the plasmoid width w, corresponding to a Larmor radius ∼0.2 w; the plasmoids grow in size at ∼0.1 of the speed of light, with most of the growth happening while they are still non-relativistic (`first they grow'); their growth is suppressed once they get accelerated to relativistic speeds by the field line tension, up to the Alfvén speed (`then they go'). The largest plasmoids reach a width wmax ∼ 0.2 L independently of the system length L, they have nearly isotropic particle distributions and contain the highest energy particles, whose Larmor radius is ∼0.03 L. The latter can be regarded as the Hillas criterion for relativistic reconnection. We briefly discuss the implications of our results for the high-energy emission from relativistic jets and pulsar winds.

The conditions for the occurrence of strong magnetotransverse anisotropy in light scattering by a single gyrotropic sphere are investigated by means of rigorous full electrodynamic multipole calculations. It is shown that composite magnetoplasmonic spherical scatterers with a core–shell morphology can induce large and tunable plasmon-driven Hall photon currents, which appear even in the case of subwavelength particles. Explicit results for silver-coated bismuth-substituted yttrium iron garnet nanospheres are presented and analyzed.

Lake Ohrid is located at the border between FYROM (Former Yugoslavian Republic of Macedonia) and Albania and formed during the latest phases of Alpine orogenesis. It is the deepest, the largest and the oldest tectonic lake in Europe. To better understand the paleoclimatic and paleoenvironmental evolution of Lake Ohrid, deep drilling was carried out in 2013 within the framework of the Scientific Collaboration on Past Speciation Conditions (SCOPSCO) project that was funded by the International Continental Scientific Drilling Program (ICDP). Preliminary results indicate that lacustrine sedimentation of Lake Ohrid started between 1.2 and 1.9 Ma ago. Here we present new pollen data (selected percentage and concentration taxa/groups) of the uppermost  ∼  200 m of the 569 m long DEEP core drilled in the depocentre of Lake Ohrid. The study is the fruit of a cooperative work carried out in several European palynological laboratories. The age model of this part of the core is based on 10 tephra layers and on tuning of biogeochemical proxy data to orbital parameters. According to the age model, the studied sequence covers the last  ∼  500 000 years at a millennial-scale resolution ( ∼  1.6 ka) and records the major vegetation and climate changes that occurred during the last 12 (13 only pro parte) marine isotope stages (MIS). Our results indicate that there is a general good correspondence between forested/non-forested periods and glacial–interglacial cycles of the marine isotope stratigraphy. The record shows a progressive change from cooler and wetter to warmer and drier interglacial conditions. This shift in temperature and moisture availability is visible also in vegetation during glacial periods. The period corresponding to MIS11 (pollen assemblage zone OD-10, 428–368 ka BP) is dominated by montane trees such as conifers. Mesophilous elements such as deciduous and semi-deciduous oaks dominate forest periods of MIS5 (PASZ OD-3, 129–70 ka BP) and MIS1 (PASZ OD-1, 14 ka BP to present). Moreover, MIS7 (PASZ OD-6, 245–190 ka) shows a very high interglacial variability, with alternating expansions of montane and mesophilous arboreal taxa. Grasslands (open vegetation formations requiring relatively humid conditions) characterize the earlier glacial phases of MIS12 (PASZ OD-12, 488–459 ka), MIS10 (corresponding to the central part of PASZ OD-10, 428–366 ka) and MIS8 (PASZ OD-7, 288–245 ka). Steppes (open vegetation formations typical of dry environments) prevail during MIS6 (OD-5 and OD-4, 190–129 ka) and during MIS4-2 (PASZ OD-2, 70–14 ka). Our palynological results support the notion that Lake Ohrid has been a refugium area for both temperate and montane trees during glacials. Closer comparisons with other long southern European and Near Eastern pollen records will be achieved through ongoing high-resolution studies.

Renal impairment (RI) is a major comorbidity in patients with multiple myeloma (MM). Here we present the pooled safety and efficacy analysis of three clinical trials (MM-002, MM-003, and MM-010) of pomalidomide + low-dose dexamethasone (POM + LoDEX) in patients with moderate RI (creatinine clearance [CrCl] ≥ 30 to <60 mL/min) and without RI (≥ 60 mL/min). Trial protocols were approved by the institutional review board of each site involved. Patients with RI were older than patients without RI, although other baseline characteristics were similar. The dosing and safety profile of POM + LoDEX was similar across RI subgroups. Median overall response rate, progression-free survival, time to progression, and duration of response were not significantly different between RI subgroups. However, patients with vs. without RI had significantly shorter median overall survival (10.5 vs. 14.0 months, respectively; p =.004). This analysis demonstrates that POM + LoDEX is a safe and effective treatment for patients with moderate RI. The trials were registered at ClinicalTrials.gov as NCT00833833 (MM-002), NCT01311687 (MM-003), and NCT01712789 (MM-010) and at EudraCT as 2010-019820-30 (MM-003) and 2012-001888-78 (MM-010). © 2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

Renal impairment (RI) is a major comorbidity in patients with multiple myeloma (MM). Here we present the pooled safety and efficacy analysis of three clinical trials (MM-002, MM-003, and MM-010) of pomalidomide + low-dose dexamethasone (POM + LoDEX) in patients with moderate RI (creatinine clearance [CrCl] ≥ 30 to <60 mL/min) and without RI (≥ 60 mL/min). Trial protocols were approved by the institutional review board of each site involved. Patients with RI were older than patients without RI, although other baseline characteristics were similar. The dosing and safety profile of POM + LoDEX was similar across RI subgroups. Median overall response rate, progression-free survival, time to progression, and duration of response were not significantly different between RI subgroups. However, patients with vs. without RI had significantly shorter median overall survival (10.5 vs. 14.0 months, respectively; p =.004). This analysis demonstrates that POM + LoDEX is a safe and effective treatment for patients with moderate RI. The trials were registered at ClinicalTrials.gov as NCT00833833 (MM-002), NCT01311687 (MM-003), and NCT01712789 (MM-010) and at EudraCT as 2010-019820-30 (MM-003) and 2012-001888-78 (MM-010). © 2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

Aims: We present a comprehensive X-ray study of the population of supernova remnants (SNRs) in the Large Magellanic Cloud (LMC). Using primarily XMM-Newton observations, we conduct a systematic spectral analysis of LMC SNRs to gain new insight into their evolution and the interplay with their host galaxy. Methods: We combined all the archival XMM-Newton observations of the LMC with those of our Very Large Programme LMC survey. We produced X-ray images and spectra of 51 SNRs, out of a list of 59 objects compiled from the literature and augmented with newly found objects. Using a careful modelling of the background, we consistently analysed all the X-ray spectra and measure temperatures, luminosities, and chemical compositions. The locations of SNRs are compared to the distributions of stars, cold gas, and warm gas in the LMC, and we investigated the connection between the SNRs and their local environment, characterised by various star formation histories. We tentatively typed all LMC SNRs, in order to constrain the ratio of core-collapse to type Ia SN rates in the LMC. We also compared the column densities derived from X-ray spectra to H I maps, thus probing the three-dimensional structure of the LMC. Results: This work provides the first homogeneous catalogue of the X-ray spectral properties of SNRs in the LMC. It offers a complete census of LMC remnants whose X-ray emission exhibits Fe K lines (13% of the sample), or reveals the contribution from hot supernova ejecta (39%), which both give clues to the progenitor types. The abundances of O, Ne, Mg, Si, and Fe in the hot phase of the LMC interstellar medium are found to be between 0.2 and 0.5 times the solar values with a lower abundance ratio [α/Fe] than in the Milky Way. The current ratio of core-collapse to type Ia SN rates in the LMC is constrained to NCC/NIa=1.35(-0.24+0.11), which is lower than in local SN surveys and galaxy clusters. Our comparison of the X-ray luminosity functions of SNRs in Local Group galaxies (LMC, SMC, M31, and M33) reveals an intriguing excess of bright objects in the LMC. Finally, we confirm that 30 Doradus and the LMC Bar are offset from the main disc of the LMC to the far and near sides, respectively. Based on observations obtained with XMM-Newton, an ESA science mission with instruments and contributions directly funded by ESA Member States and NASA.

A population pharmacokinetic (PK) model and exposure-response (E-R) analysis was developed using data collected from 5 phase 1b/2 and 2 phase 3 studies in subjects with multiple myeloma. Subjects receiving intravenous infusion on 2 consecutive days each week for 3 weeks (days 1, 2, 8, 9, 15, and 16) in each cycle at doses ranging from 15 to 20/56 mg/m2 (20 mg/m2 in cycle 1 and, if tolerated, escalated to 56 mg/m2 on day 8 of cycle 1). The population PK analysis indicated that among all the covariates tested, the only statistically significant covariate was body surface area on carfilzomib clearance; however, this covariate was unlikely to be clinically significant. Despite inclusion of different populations (relapsed or relapsed/refractory), treatments (carfilzomib monotherapy or combination therapy), infusion lengths (2 to 10 minutes or 30 minutes), and different doses, the E-R analysis of efficacy showed that after adjusting for baseline characteristics, higher area under the concentration-time curve was associated with improved overall response rate (ORR), from 15 to 20/56 mg/m2. No positive relationships between maximum concentration and ORR were identified, indicating that ORR would not be expected to be impacted by infusion length. For safety end points, no statistically significant relationship between exposure and increasing risk of adverse events was identified. The results of an E-R analysis provided strong support for a carfilzomib dose at 20/56 mg/m2 as a 30-minute infusion for monotherapy and combination therapy. This article illustrates an example of application of E-R analysis to support labeling dose recommendation in the absence of extensive clinical data. © 2016, The American College of Clinical Pharmacology.

On July 17, 2015 a forest fire that broke out in the southern part of Epidavros Limira peninsula (Laconia, southeastern Peloponnese), expanded rapidly due to strong winds blowing in the area and raged out of control for two days, inducing substantial damage to agriculture, livestock farming, buildings and infrastructure and causing one fatality. Innovative GIS-based methods were developed and implemented for the first time in a fire-affected area in Greece for mapping the post-fire erosion, flood and landslide hazards and risks. Geomorphological, geological, tectonic, hydrological, meteorological and land-use data along with a WorldView-2 satellite image and post-fire field observations were evaluated and used. A newly developed method was applied for assessing the erosion hazard. Analytic Hierarchy Process and Weighted Linear Combination methods were used for assessing the post-fire landslide susceptibility. The HEC-RAS model was used for hydraulic simulation and assessment of flood risk under post-fire conditions. Post-fire erosion, flood and landslide hazard and risk maps were constructed for the affected area delineating locations with very low, low, moderate, high or very high hazard and risk of erosion, flood and landslide respectively. The developed methodology is a useful post-fire hazard and risk assessment tool and can be applied by state authorities to assess the geo-environmental impact of fire disasters in areas with similar environmental conditions.

Monoclonal antibodies (mAbs) are a recent addition to multiple myeloma (MM) therapies and a number of mAbs directed at myeloma cell surface molecules are in development. Daratumumab is a CD38 mAb that has demonstrated substantial activity and good tolerability in four phase I, phase I/II and phase II studies as monotherapy, as well as in combination with current standard treatments in MM. The positive results obtained in the relapsed/refractory setting in patients with advanced-stage disease and in a small number of patients with newly diagnosed disease provide the rationale for the investigation of the agent in a number of ongoing phase III trials. mAbs are generally better tolerated than conventional chemotherapy; however, their use requires other special considerations. Such factors include those common to all mAbs, namely infusion-related reactions, but also factors that are observed with mAbs used in myeloma, such as interference with response assessment, or factors that are related to CD38 mAbs such as daratumumab, for instance blood typing interference. Our review provides an overview of the results from the daratumumab clinical trials conducted to date, as well as practical management considerations for the use of daratumumab based on our experience with the agent. © 2016 Springer International Publishing Switzerland.

Monoclonal antibodies (mAbs) are a recent addition to multiple myeloma (MM) therapies and a number of mAbs directed at myeloma cell surface molecules are in development. Daratumumab is a CD38 mAb that has demonstrated substantial activity and good tolerability in four phase I, phase I/II and phase II studies as monotherapy, as well as in combination with current standard treatments in MM. The positive results obtained in the relapsed/refractory setting in patients with advanced-stage disease and in a small number of patients with newly diagnosed disease provide the rationale for the investigation of the agent in a number of ongoing phase III trials. mAbs are generally better tolerated than conventional chemotherapy; however, their use requires other special considerations. Such factors include those common to all mAbs, namely infusion-related reactions, but also factors that are observed with mAbs used in myeloma, such as interference with response assessment, or factors that are related to CD38 mAbs such as daratumumab, for instance blood typing interference. Our review provides an overview of the results from the daratumumab clinical trials conducted to date, as well as practical management considerations for the use of daratumumab based on our experience with the agent. © 2016 Springer International Publishing Switzerland.

OBJECTIVES: To evaluate the prevalence and its clinical characteristics of psoriatic arthritis (PsA) in a specialized psoriasis clinic of a University Hospital. METHODS: In this retrospective study, 278 patients with psoriasis were evaluated between 2011 and 2013. RESULTS: The study included 278 patients with psoriasis: 144 (52%) were male and 134 (48%) female. Their median age was 51.41 with median psoriasis presenting age of 34.52 years. Referring to the type of psoriasis, 86% presented with plaque psoriasis, 5% guttate, 2% palms and soles, 2% inverse, 1% pustular and 4% with psoriasis of more than one type. Nail disease appeared in 121 patients (43.5%) and scalp disease in 175 (63%). Of these patients, 85 (30%) had PsA, whereas 51% of patients with PsA had psoriatic nail disease. With reference to the PsA type, 43 (51%) patients presented with polyarthritis, 10 (12%) with oligoarthritis, 7 (8%) with axial arthritis, whereas the rest 25 of them (31%) had PsA of more than one type. The subgroup of patients with PsA had significantly higher rates of comorbidities including arterial hypertension, diabetes and hypercholesterolaemia compared to non-PsA patients with 41% vs. 17% (P = 0.001), 20% vs. 8% (P = 0.021) and 41% vs. 19% (P = 0.004), respectively. CONCLUSION: The prevalence of PsA among patients with psoriasis was relatively higher in Greece compared to other ethnic-based studies. Comorbidities related to life expectancy were more frequent. As there is a high percentage of undiagnosed cases with active arthritis among patients with psoriasis, dermatologists should be aware of PsA clinical signs in order to recognize it earlier and provide successful treatment.

OJ 287 is a quasi-periodic quasar with roughly 12 year optical cycles. It displays prominent outbursts that are predictable in a binary black hole model. The model predicted a major optical outburst in 2015 December. We found that the outburst did occur within the expected time range, peaking on 2015 December 5 at magnitude 12.9 in the optical R-band. Based on Swift/XRT satellite measurements and optical polarization data, we find that it included a major thermal component. Its timing provides an accurate estimate for the spin of the primary black hole, χ =0.313+/- 0.01. The present outburst also confirms the established general relativistic properties of the system such as the loss of orbital energy to gravitational radiation at the 2% accuracy level, and it opens up the possibility of testing the black hole no-hair theorem with 10% accuracy during the present decade.

Botezomib-based induction is highly effective for the treatment of newly diagnosed multiple myeloma (NDMM). We investigated the outcomes of NDMM patients who failed to respond to bortezomib-based induction in a real-life clinical setting. In a cohort of 295 consecutive NDMM patients in 3 medical centers, 74 (25%) failed to achieve at least partial response after 4 induction cycles, and were classified as non-responsive. Compared to induction responders, they were older, more frequently anemic, had a higher incidence of del17p and ISS-3, and a worse performance status. In multivariable analysis, bortezomib-based induction failure occurred in 25% of patients and was the strongest independent factor predicting mortality with a 5-fold hazard ratio (95% CI 1.44-8.68). Three-year overall survival in responsive vs. non-responsive patients were 76% vs. 53%, respectively (p < 0.0001). Survival from time of salvage second-line treatment was significantly shorter among induction non-responders vs. responders (25 months vs. not-reached, p = 0.024). © 2015 Taylor & Francis.

Botezomib-based induction is highly effective for the treatment of newly diagnosed multiple myeloma (NDMM). We investigated the outcomes of NDMM patients who failed to respond to bortezomib-based induction in a real-life clinical setting. In a cohort of 295 consecutive NDMM patients in 3 medical centers, 74 (25%) failed to achieve at least partial response after 4 induction cycles, and were classified as non-responsive. Compared to induction responders, they were older, more frequently anemic, had a higher incidence of del17p and ISS-3, and a worse performance status. In multivariable analysis, bortezomib-based induction failure occurred in 25% of patients and was the strongest independent factor predicting mortality with a 5-fold hazard ratio (95% CI 1.44-8.68). Three-year overall survival in responsive vs. non-responsive patients were 76% vs. 53%, respectively (p < 0.0001). Survival from time of salvage second-line treatment was significantly shorter among induction non-responders vs. responders (25 months vs. not-reached, p = 0.024). © 2015 Taylor & Francis.

The International Committee for the Taxonomy and Nomenclature of Viruses does not rule on virus classifications below the species level. The definition of species for viruses cannot be clearly defined for all types of viruses. The complex and interesting epidemiology of Human Immunodeficiency Viruses demands a detailed and informative nomenclature system, while at the same time it presents challenges such that many of the rules need to be flexibly applied or modified over time. This review outlines the nomenclature system for primate lentiviruses and provides an update on new findings since the last review was written in 2000.

MicroRNAs are small, non-coding RNAs which regulate post-transcriptionally hundreds of target mRNAs. Given that their expression is deregulated in several cancer types, they represent potential diagnostic, prognostic, and predictive biomarkers, as well as next-generation therapeutic targets. Nevertheless, the involvement of miRNAs in non-melanoma skin cancer, a cancer type with increasing prevalence, is not extensively studied, and their comprehensive characterization as regard to the initiation, promotion, and progression stages is missing. To this end, we exploited a well-established multistage mouse skin carcinogenesis model in order to identify miRNAs consistently implicated in different stages of skin carcinogenesis. The cell lines comprising this model were subjected to miRNA expression profiling using microarrays, followed by bioinformatics analysis and validation with Q-PCR, as well as treatment with miRNA modulators. We showed that among all deregulated miRNAs in our system, only a functionally coherent group consisting of the miR-200 family members and miR-205-5p displays a pattern of progressive co-downregulation from the early toward the most aggressive stages of carcinogenesis. Their overlapping, co-regulated putative targets are potentially inter-associated and, of these, the EMT-related Rap1a is overexpressed toward aggressive stages. Ectopic expression of miR-205-5p in spindle cancer cells reduces Rap1a, mitigates cell invasiveness, decreases proliferation, and delays tumor onset. We conclude that deregulation of this miRNA group is primarily associated with aggressive phenotypes of skin cancer cells. Restoration of the miR-205-5p member of this group in spindle cells reduces the expression of critical, co-regulated targets that favor cancer progression, thus reversing the EMT characteristics. © 2015 Wiley Periodicals, Inc.

The absolute power of a relativistic black hole jet includes the power in the magnetic field, the leptons, the hadrons, and the radiated photons. A power analysis of a relativistic radio/γ-ray blazar jet leads to bifurcated leptonic synchrotron-Compton (LSC) and leptohadronic synchrotron (LHS) solutions that minimize the total jet power. Higher Doppler factors with increasing peak synchrotron frequency are implied in the LSC model. Strong magnetic fields {B}\prime ≳ 100 {{G}} are found for the LHS model with variability times ≲ {10}3 {{s}}, in accord with highly magnetized, reconnection-driven jet models. Proton synchrotron models of ≳ 100 {GeV} blazar radiation can have sub-Eddington absolute jet powers, but models of dominant GeV radiation in flat spectrum radio quasars require excessive power.

A variety of medications have been implicated in the causation of thrombotic microangiopathy (TMA). Recently, a few case reports have emerged of TMA attributed to the proteasome inhibitors (PI) bortezomib and carfilzomib in patients with multiple myeloma. The aim of this case series was to better characterize the role of PI in the etiology of drug-induced TMA. We describe eleven patients from six medical centers from around the world who developed TMA while being treated with PI. The median time between medication initiation and diagnosis of TMA was 21 days (range 5 days to 17 months). Median laboratory values at diagnosis included hemoglobin—7.5 g dL−1, platelet count—20 × 109/L, LDH—698 U L−1, creatinine—3.12 mg dL−1. No patient had any other cause of TMA, including ADAMTS13 inhibition, other malignancy or use of any other medication previously associated with TMA. Nine patients had resolution of TMA without evidence of hemolysis after withdrawal of PI. Two patients had stabilization of laboratory values but persistent evidence of hemolysis despite medication withdrawal. One patient had recurrence of TMA with rechallenge of PI. There is a strong level of evidence that PI can cause DITMA. In evaluating patients with suspected TMA, PI use should be recognized as a potential etiology, and these medications should be discontinued promptly if thought to be the cause of TMA. Am. J. Hematol. 91:E348–E352, 2016. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

A variety of medications have been implicated in the causation of thrombotic microangiopathy (TMA). Recently, a few case reports have emerged of TMA attributed to the proteasome inhibitors (PI) bortezomib and carfilzomib in patients with multiple myeloma. The aim of this case series was to better characterize the role of PI in the etiology of drug-induced TMA. We describe eleven patients from six medical centers from around the world who developed TMA while being treated with PI. The median time between medication initiation and diagnosis of TMA was 21 days (range 5 days to 17 months). Median laboratory values at diagnosis included hemoglobin—7.5 g dL−1, platelet count—20 × 109/L, LDH—698 U L−1, creatinine—3.12 mg dL−1. No patient had any other cause of TMA, including ADAMTS13 inhibition, other malignancy or use of any other medication previously associated with TMA. Nine patients had resolution of TMA without evidence of hemolysis after withdrawal of PI. Two patients had stabilization of laboratory values but persistent evidence of hemolysis despite medication withdrawal. One patient had recurrence of TMA with rechallenge of PI. There is a strong level of evidence that PI can cause DITMA. In evaluating patients with suspected TMA, PI use should be recognized as a potential etiology, and these medications should be discontinued promptly if thought to be the cause of TMA. Am. J. Hematol. 91:E348–E352, 2016. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

We request a 50 ks observation of a pulsating (P~170 s), accretingwhite dwarf binary located in the Large Magellanic Cloud. The systemwas serendipitously detected off-axis during analysis of an archivalXMM-Newton observation (2013) that was severely contaminated by highbackground. Such objects are thought to be candidates for the progenitorsof type Ia supernovae, or may alternatively undergo accretion-inducedcollapse to form the neutron stars in some millisecond pulsars. Thenature of their short period oscillations remains unknown. The on-axisXMM-Newton observation proposed below would deliver a much improvedspectrum, allowing precise characterisation of the system.

Several supernovae (SNe) with an unusually dense circumstellar medium (CSM) have been recently observed at radio frequencies. Their radio emission is powered by relativistic electrons that can be either accelerated at the SN shock (primaries) or injected as a by-product (secondaries) of inelastic proton-proton collisions. We investigate the radio signatures from secondary electrons, by detailing a semi-analytical model to calculate the temporal evolution of the distributions of protons, primary and secondary electrons. With our formalism, we track the cooling history of all the particles that have been injected into the emission region up to a given time, and calculate the resulting radio spectra and light curves. For an SN shock propagating through the progenitor wind, we find that secondary electrons control the early radio signatures, but their contribution decays faster than that of primary electrons. This results in a flattening of the light curve at a given radio frequency that depends only upon the radial profiles of the CSM density and of the shock velocity, υ0. The relevant transition time at the peak frequency is {∼ } {190} d K_ep,-3^{-1} A_{w, 16}{/β _{0, -1.5}^2}, where Aw is the wind mass-loading parameter, β0 = υ0/c and Kep are the electron-to-proton ratio of accelerated particles. We explicitly show that late peak times at 5 GHz (I.e. tpk ≳ 300-1000 d) suggest a shock wave propagating in a dense wind (Aw ≳ 1016-1017 gr cm-1), where secondary electrons are likely to power the observed peak emission.

The rate of force development (RFD) is an essential component for performance in explosive activities, although it has been proposed that muscle architectural characteristics might be linked with RFD and power performance. The purpose of the study was to investigate the relationship between RFD, muscle architecture, and performance in young track and field throwers. Twelve young track and field throwers completed 10 weeks of periodized training. Before (T1) and after (T2) training performance was evaluated in competitive track and field throws, commonly used shot put tests, isometric leg press RFD, 1 repetition maximum (1RM) strength as well as vastus lateralis architecture and body composition. Performance in competitive track and field throwing and the shot put test from the power position increased by 6.76 ± 4.31% (p < 0.001) and 3.58 ± 4.97% (p = 0.019), respectively. Rate of force development and 1RM strength also increased (p ≤ 0.05). Vastus lateralis thickness and fascicle length increased by 5.95 ± 7.13% (p = 0.012) and 13.41 ± 16.15% (p = 0.016), respectively. Significant correlations were found at T1 and T2, between performance in the shot put tests and both RFD and fascicle length (p ≤ 0.05). Close correlations were found between RFD, muscle thickness, and fascicle length (p ≤ 0.05). Significant correlations were found between the % changes in lean body mass and the % increases in RFD. When calculated together, the % increase in muscle thickness and RFD could predict the % increase in shot put throw test from the power position (p = 0.019). These results suggest that leg press RFD may predict performance in shot put tests that are commonly used by track and field throwers.

The last 3,000 years of relative sea level (RSL) in Israel are derived primarily from archaeological indicators with additional bio-construction indicators (Dendropoma petraeum reefs at the edge of the abrasion platform along the Israeli coast). The current study examines whether sea-level fluctuations (above and mainly below present-day MSL) observed along the coast of Israel can also be observed in other East Mediterranean areas like Greece so that better evaluations can be made of local and regional driving mechanisms. There are three objectives for achieving this goal: 1) Identify new and already published archaeological and biological RSL indicators from this period in Israel and Greece; 2) Assess the reliability of both existing and new indicators using consistent standards to determine which types most accurately indicate ancient RSL and with what degree of uncertainty; 3) Correct the data for isostatic and tectonic effects. The survey collected nearly 140 archaeological indicators from Israel and about 120 from Greece. Of the Israeli indicators, some 120 were deemed reliable enough for reconstructions, whereas in Greece only 40 were, and not all of these from tectonically stable areas. The Israeli data includes 31 dates obtained from Dendropoma reefs in Israel. The higher reliability of the Israeli dataset may stem from a smaller coastline and more focused SL research over the past few decades. In Greece, many measurements were taken before precise surveying methods were available, and published without sufficient metadata. The two regional datasets reveal chronological gaps and disparities: Israel has a strong set of many indicators from the Roman Period (2000BP) to present, but fewer from 3000-2000BP, while Greek indicators are strongly clustered in the Classical to Hellenistic Periods (2500-2000BP). On-going research is focusing now also on the last Millennial Greek sea levels (mainly the ‘Venetian’ period). Results however suggest some correspondence and support previous Israeli conclusions suggesting somewhat lower levels around 2500BP and in the first half of the last Millennium: The Crusader period in Israel (11th to 13th century AD) and the Venetian period in Greece (12th to 15th century AD). Near-present, stable levels are indicated during most other periods, despite indications of slightly higher sea levels in the late Roman/Byzantine period.

Immunoglobulin light chain (AL) amyloidosis, the most common of the systemic amyloidosis, is characterized by the deposition of amyloid fibrils that derive from the aggregation of misfolded monoclonal immunoglobulin light chains. Amyloid fibrils disrupt tissue architecture and the pre-fibril oligomers are directly toxic to myocardiac cells, causing cardiac dysfunction. The lethal consequences of AL amyloidosis are due to the toxic product and not due to the malignant behaviour of the plasma cell clone however, the characteristics of this clone are associated with long-term prognosis. Early and accurate diagnosis is the key to effective management, but is challenging. Modern chemotherapy options (including autologous transplantation, bortezomib, lenalidomide) have improved the outcomes of patients at low or intermediate risk, but the prognosis of patients with severe cardiac dysfunction is still poor. Therapies targeting amyloid deposits and the amyloidogenic process are under investigation and offer promise for better future treatments. © 2016 John Wiley & Sons Ltd.

We present results from the latest outburst of the Be/X-ray binary system SMC X-2, which in late 2015 entered it's first X-ray outburst since 2000. SMC X-2 was first discovered in 1977 by the SAS-3 satellite, and hosts a 2.37s period pulsar. Regular, almost daily, Swift observations of SMC X-2 were performed during the entirety of the latest outburst, from first detection by MAXI to it’s rapid turn off and return back to quiescence. These observations have allowed us to measure with the flux, spectral and temporal properties of SMC X-2. Timing analysis of observation by the Swift X-ray telescope allowed us to track the evolution of the pulsar spin period, and in addition modeling of the orbital parameters of the system by measuring changes in the pulsar spin period due to Doppler effects. In addition we report on an observation of SMC X-2 taken with NuSTAR, which allowed both to better measure the continuum fit above 10 keV, and to perform a sensitive measure of the pulse profile and period of the source.

This document is based on the original recommendation of the Expert Panel on the Theory of Reference Values of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC), updated guidelines were recently published under the auspices of the IFCC and the Clinical and Laboratory Standards Institute (CLSI). This document summarizes proposals for recommendations on: (i) The terminology, which is often confusing, noticeably concerning the terms of reference limits and decision limits. (ii) The method for the determination of reference limits according to the original procedure and the conditions, which should be used. (iii) A simple procedure allowing the medical laboratories to fulfill the requirements of the regulation and standards. The updated document proposes to verify that published reference limits are applicable to the laboratory involved. Finally, the strengths and limits of the revised recommendations (especially the selection of the reference population, the maintenance of the analytical quality, the choice of the statistical method used...) will be briefly discussed

The diagnosis of Waldenström macroglobulinaemia (WM) can be challenging given the variety of signs and symptoms patients can present. Furthermore, once the diagnosis of WM is established, the initial evaluation should be thorough as well as appropriately directed. During the 8th International Workshop for WM in London, United Kingdom, a multi-institutional task force was formed to develop consensus recommendations for the diagnosis and initial evaluation of patients with WM. In this document, we present the results of the deliberations that took place to address these issues. We provide recommendations for history-taking and physical examination, laboratory studies, bone marrow aspiration and biopsy analysis and imaging studies. We also provide guidance on the initial evaluation of special situations, such as anaemia, hyperviscosity, neuropathy, Bing-Neel syndrome and amyloidosis. We hope these recommendations serve as a practical guidance to clinicians taking care of patients with a suspected or an established diagnosis of WM. © 2016 John Wiley & Sons Ltd

The diagnosis of Waldenström macroglobulinaemia (WM) can be challenging given the variety of signs and symptoms patients can present. Furthermore, once the diagnosis of WM is established, the initial evaluation should be thorough as well as appropriately directed. During the 8th International Workshop for WM in London, United Kingdom, a multi-institutional task force was formed to develop consensus recommendations for the diagnosis and initial evaluation of patients with WM. In this document, we present the results of the deliberations that took place to address these issues. We provide recommendations for history-taking and physical examination, laboratory studies, bone marrow aspiration and biopsy analysis and imaging studies. We also provide guidance on the initial evaluation of special situations, such as anaemia, hyperviscosity, neuropathy, Bing-Neel syndrome and amyloidosis. We hope these recommendations serve as a practical guidance to clinicians taking care of patients with a suspected or an established diagnosis of WM. © 2016 John Wiley & Sons Ltd

OBJECTIVE: Although our understanding of viral transmission among people who inject drugs (PWID) has improved, we still know little about when and how many times each injector transmits HIV throughout the duration of infection. We describe HIV dynamics in PWID to evaluate which preventive strategies can be efficient. DESIGN: Due to the notably scarce interventions, HIV-1 spread explosively in Russia and Ukraine in 1990s. By studying this epidemic between 1995 and 2005, we characterized naturally occurring transmission dynamics of HIV among PWID. METHOD: We combined publicly available HIV pol and env sequences with prevalence estimates from Russia and Ukraine under an evolutionary epidemiology framework to characterize HIV transmissibility between PWID. We then constructed compartmental models to simulate HIV spread among PWID. RESULTS: In the absence of interventions, each injector transmits on average to 10 others. Half of the transmissions take place within 1 month after primary infection, suggesting that the epidemic will expand even after blocking all the post-first month transmissions. Primary prevention can realistically target the first month of infection, and we show that it is very efficient to control the spread of HIV-1 in PWID. Treating acutely infected on top of primary prevention is notably effective. CONCLUSION: As a large proportion of transmissions among PWID occur within 1 month after infection, reducing and delaying transmissions through scale-up of harm reduction programmes should always form the backbone of HIV control strategies in PWID. Growing PWID populations in the developing world, where primary prevention is scarce, constitutes a public health time bomb.

We analyzed a large number of focal mechanisms and relocated earthquake hypocenters to investigate the geodynamics of western Greece, the most seismically active part of the Aegean plate-boundary zone. This region was seismically activated multiple times during the last decade, providing a large amount of enhanced quality new information that was obtained by the Hellenic Unified Seismological Network (HUSN). Relocated seismicity appears concentrated above 25 km depth, exhibiting spatial continuity along the convergence boundary andbeing clustered elsewhere. Earthquakes are confined within the accreted sediments escarpment of the down-going African plate against the un-deformed Pindos hinterland. The data arrangement shows that Pindos constitutes a seismic boundary along which large stress heterogeneities occur. Surprisingly, in Cephalonia no seismicity related with the offshore Cephalonia Transform Fault (CTF) is observed. Onshore, N-S crustal extension dominates, while in central and south Peloponnesus the stress field appears rotated by 90°. Shearing-stress obliquity by 30° is indicated along the major strike-slip faults, consistent with clockwise crustal rotation. Within the lower crust, the stress field appears constrained by plate kinematics and the distributed deformation, which guide the geodynamics of the area.Seismic velocity anomalies have been resolved by regional body-wave traveltime tomography applying an iterative tomographic inversion scheme using phase data from more than 5,000 seismic events recorded by the Hellenic Unified Seismological Network (HUSN), analyzed by the Seismological Laboratory of the Universityof Athens. Preliminary 3D tomographic models indicate the presence of gross structures related with Pindus hinterland, the Tethys subduction beneath the Aegean, and shear zones related with the CTF and the Andravida fault. A predominant NE-SW oriented low velocity zone in central Peloponnesus is related with the rotation of the extensional stress field and dextral strike-slip faulting.

Relapsed/refractory multiple myeloma (RRMM) patients have poor overall survival (OS). Pomalidomide plus low-dose dexamethasone (POM + LoDEX) significantly extends OS in RRMM vs. high-dose dexamethasone. Survival of patients with stable disease (SD) was compared to patients with progressive disease (PD) or ≥ partial response (≥PR) at cycles (C) 3, 5, and 7. Among 302 patients randomized to POM + LoDEX, at C3 19.2% achieved ≥ PR, 38.4% SD, and 14.6% PD. Patients with SD at C3 (17.4%) and C5 (13.6%) showed improved responses at C7. Median OS from randomization by response at C3 was 22.4 months for ≥ PR (n = 58, HR 0.66; 95% CI 0.40–1.08, p = 0.0976 vs. SD), 16.2 months for SD (n = 116), and 6.3 months for PD (n = 44, HR 3.43; 95% CI 2.23–5.27, p < 0.0001 vs. SD). Similar patterns were observed for C5 and C7. Results show that POM + LoDEX should be a standard treatment after lenalidomide and bortezomib, including in SD patients. © 2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

Relapsed/refractory multiple myeloma (RRMM) patients have poor overall survival (OS). Pomalidomide plus low-dose dexamethasone (POM + LoDEX) significantly extends OS in RRMM vs. high-dose dexamethasone. Survival of patients with stable disease (SD) was compared to patients with progressive disease (PD) or ≥ partial response (≥PR) at cycles (C) 3, 5, and 7. Among 302 patients randomized to POM + LoDEX, at C3 19.2% achieved ≥ PR, 38.4% SD, and 14.6% PD. Patients with SD at C3 (17.4%) and C5 (13.6%) showed improved responses at C7. Median OS from randomization by response at C3 was 22.4 months for ≥ PR (n = 58, HR 0.66; 95% CI 0.40–1.08, p = 0.0976 vs. SD), 16.2 months for SD (n = 116), and 6.3 months for PD (n = 44, HR 3.43; 95% CI 2.23–5.27, p < 0.0001 vs. SD). Similar patterns were observed for C5 and C7. Results show that POM + LoDEX should be a standard treatment after lenalidomide and bortezomib, including in SD patients. © 2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

Introduction: Patients with multiple myeloma (MM) have an increased risk of venous thromboembolic (VTE) complications. The first reports of high VTE rates date back to 1999 but became more apparent with the introduction of novel agents in the treatment of MM and mostly with immunomodulatory drugs (IMiDs; thalidomide, lenalidomide and pomalidomide). Areas covered: Currently thromboprophylaxis is recommended for patients who receive IMiDs-based regimens and the type of thrombophrophylaxis is based on patient-, disease- and treatment-related risk factors. Making the distinction between the intrinsic risk of thrombosis in MM and the effect of therapy is crucial. The use of aspirin, low molecular weight heparins and warfarin are the recommended drugs but despite their appropriate use the rates of VTE are not completely eliminated. Expert commentary: Research into biomarkers of increased coagulability and their incorporation in risk assessment models could identify patients most likely to benefit from thromboprophylaxis but such models are not widely used in myeloma. © 2016 Informa UK Limited, trading as Taylor & Francis Group.

Introduction: Patients with multiple myeloma (MM) have an increased risk of venous thromboembolic (VTE) complications. The first reports of high VTE rates date back to 1999 but became more apparent with the introduction of novel agents in the treatment of MM and mostly with immunomodulatory drugs (IMiDs; thalidomide, lenalidomide and pomalidomide). Areas covered: Currently thromboprophylaxis is recommended for patients who receive IMiDs-based regimens and the type of thrombophrophylaxis is based on patient-, disease- and treatment-related risk factors. Making the distinction between the intrinsic risk of thrombosis in MM and the effect of therapy is crucial. The use of aspirin, low molecular weight heparins and warfarin are the recommended drugs but despite their appropriate use the rates of VTE are not completely eliminated. Expert commentary: Research into biomarkers of increased coagulability and their incorporation in risk assessment models could identify patients most likely to benefit from thromboprophylaxis but such models are not widely used in myeloma. © 2016 Informa UK Limited, trading as Taylor & Francis Group.

A fully automatic remote telescope and dome control system has been installed at the University of Athens Observatory (UOAO) in August 2012. It was constructed in the Laboratory of Astronomy and Applied Optics of the department and incorporated the already existing automation for observations and data gathering techniques. The system proved to be reliable and functions faultlessly up to date, enabling the astronomers to observe remotely from any place, using the network. The observing nights have been increased significantly after the first year of remote operation, reaching the number of 280 observing nights per year (77% annual usage), half of which are characterized as photometric nights of highest quality. This utility favours long-term monitoring projects of blazars and long periodic variables in general.

During the current historical coincidence, the geostrategic conjunction of Greece-Cyprus- Israel is a reality, in order for the three states to cope in the best possible manner with the contemporary and future challenges in the arena of international and regional relations. Having a common strategic perception of the geopolitical sub-system of the southeastern Mediterranean, Athens, Nicosia and Jerusalem strengthen day by day their political, diplomatic, economic and military relations, aiming at the preservation of stability in the area, against any revisionist factor. For the aforementioned strategic alliance, the discovery, extraction and exploitation of the hydrocarbon neo-reserves within the Greek, Cypriot and Israeli consecutive Exclusive Economic Zones, (EEZs), is the dynamic catalyst that reinforces even further the allied cooperation and effectiveness. Amidst the geopolitical transformation of the wider region of North Africa, Middle and Near East, the construction of the East Mediterranean Pipeline, (East-Med), is a common pursuit of the outmost significance, for the strategic alliance. Indeed, if the East-Med is realized, it will be able to transfer, in the first phase, the Israeli and Cypriot hydrocarbons from the off-shore neo-reserves via Greek sovereign territory and EEZ to Italy and central Europe, signaling EU’s gradual disengagement from the dependence on the Russian natural gas, allowing the EU to make its first steps of energy emancipation. Despite Ankara’s attempt for rapprochement with Jerusalem, the official Israeli position heavily leans towards an Israel-Greek-Cypriot strategic alignment, as Israel’s national security constitute the ultimate long-term priority for Jerusalem. Above all, such a development will upgrade the geopolitical status of all the three states of the strategic alliance in the regional geopolitical as well as the supra-geopolitical system.

The aim of the study was to examine the correlation between muscle morphology and jumping, sprinting, and throwing performance in participants with different power training duration experience. Thirty-six power-trained young men were assigned to 3 groups according to the length of their power training: less experienced (<1 year), moderately experienced (1-3 years), and experienced (4-7 years). All participants performed countermovement and squat jumps, 60-m sprint, and shot throws twice. Lean body mass (LBM) was evaluated with dual-energy x-ray absorptiometry and thigh muscle cross-sectional area (CSA) with anthropometry. The vastus lateralis architecture and fiber type composition were evaluated with ultrasonography and muscle biopsies, respectively. When all subjects were considered as 1 group (n = 36), jumping performance was correlated with LBM, fascicle length, and type II fiber CSA; sprinting performance was correlated with estimated thigh muscle CSA alone; and shot throwing was correlated with LBM and type I, IIA fiber CSA. In the least experienced group, the LBM of the lower extremities was the most significant contributor for power performance, whereas in the moderately experienced group, the LBM, architectural properties, and type II fiber percentage CSA were the most significant contributors. For the experienced group, fascicle length and type II fiber percentage CSA were the most significant factors for power performance. These data suggest that jumping performance is linked with muscle morphology, regardless of strength or power training. The vastus lateralis muscle morphology could only partially explain throwing performance, whereas it cannot predict sprinting performance. Power performance in experienced participants rely more on the quality of the muscle tissue rather than the quantity.

Patients with relapsed and/or refractory multiple myeloma (RRMM) have poor prognosis. The STRATUS study assessed safety and efficacy of pomalidomide plus low-dose dexamethasone in the largest cohort to date of patients with RRMM. Patients who failed treatment with bortezomib and lenalidomide and had adequate prior alkylator therapy were eligible. Pomalidomide 4 mg was given on days 1-21 of 28-day cycles with low-dose dexamethasone 40 mg (20 mg for patients aged >75 years) on days 1, 8, 15, and 22 until progressive disease or unacceptable toxicity. Safety was the primary end point; secondary end points included overall response rate (ORR), duration of response (DOR), progression-free survival (PFS), and overall survival (OS). Among 682 patients enrolled, median age was 66 years, and median time since diagnosis was 5.3 years. Median number of prior regimens was 5. Most patients were refractory to both lenalidomide and bortezomib (80.2%). Median follow-up was 16.8 months; median duration of treatment was 4.9 months. Most frequent grade 3/4 treatment-emergent adverse events were hematologic (neutropenia [49.7%], anemia [33.0%], and thrombocytopenia [24.1%]). Most common grade 3/4 nonhematologic toxicities were pneumonia (10.9%) and fatigue (5.9%). Grade 3/4 venous thromboembolism and peripheral neuropathy were rare (1.6% each). The ORR was 32.6%, and the median DOR was 7.4 months. Median PFS and OS were 4.6 months and 11.9 months, respectively. We present the largest trial to date evaluating pomalidomide plus low-dose dexamethasone in patients with RRMM, further confirming that this regimen offers clinically meaningful benefit and is generally well tolerated. www.Clinicaltrials.gov identifier NCT01712789. © 2016 by The American Society of Hematology.

Patients with relapsed and/or refractory multiple myeloma (RRMM) have poor prognosis. The STRATUS study assessed safety and efficacy of pomalidomide plus low-dose dexamethasone in the largest cohort to date of patients with RRMM. Patients who failed treatment with bortezomib and lenalidomide and had adequate prior alkylator therapy were eligible. Pomalidomide 4 mg was given on days 1-21 of 28-day cycles with low-dose dexamethasone 40 mg (20 mg for patients aged >75 years) on days 1, 8, 15, and 22 until progressive disease or unacceptable toxicity. Safety was the primary end point; secondary end points included overall response rate (ORR), duration of response (DOR), progression-free survival (PFS), and overall survival (OS). Among 682 patients enrolled, median age was 66 years, and median time since diagnosis was 5.3 years. Median number of prior regimens was 5. Most patients were refractory to both lenalidomide and bortezomib (80.2%). Median follow-up was 16.8 months; median duration of treatment was 4.9 months. Most frequent grade 3/4 treatment-emergent adverse events were hematologic (neutropenia [49.7%], anemia [33.0%], and thrombocytopenia [24.1%]). Most common grade 3/4 nonhematologic toxicities were pneumonia (10.9%) and fatigue (5.9%). Grade 3/4 venous thromboembolism and peripheral neuropathy were rare (1.6% each). The ORR was 32.6%, and the median DOR was 7.4 months. Median PFS and OS were 4.6 months and 11.9 months, respectively. We present the largest trial to date evaluating pomalidomide plus low-dose dexamethasone in patients with RRMM, further confirming that this regimen offers clinically meaningful benefit and is generally well tolerated. www.Clinicaltrials.gov identifier NCT01712789. © 2016 by The American Society of Hematology.

Micro-Abstract We characterized the feasibility and toxicity profile of anthracycline-containing adjuvant chemotherapy in women >65 years of age with early breast cancer. Elderly breast cancer patients derive clinical benefit comparable with that of younger patients, mainly at the cost of increased risk of hematological toxicity. © 2015 Elsevier Inc.

Micro-Abstract We characterized the feasibility and toxicity profile of anthracycline-containing adjuvant chemotherapy in women >65 years of age with early breast cancer. Elderly breast cancer patients derive clinical benefit comparable with that of younger patients, mainly at the cost of increased risk of hematological toxicity. © 2015 Elsevier Inc.

Histone acetyltransferases and histone deacetylases (HDACs) are multifunctional enzymes that posttranslationally modify both histone and nonhistone acetylation sites, affecting a broad range of cellular processes (e.g., cell cycle, apoptosis, and protein folding) often dysregulated in cancer. HDAC inhibitors are small molecules that directly interact with HDAC catalytic sites preventing the removal of acetyl groups, thereby counteracting the effects of HDACs. Since the first HDAC inhibitor, valproic acid, was investigated as a potential antitumor agent, there have been a number of other HDAC inhibitors developed to improve efficacy and safety. Despite significant progress in the management of patients with hematologic malignancies, overall survival is still poor. The discovery that HDACs may play a role in hematologic malignancies and preclinical studies showing promising activity with HDAC inhibitors in various tumor types, led to clinical evaluation of HDAC inhibitors as potential treatment options for patients with advanced hematologic malignancies. The Food and Drug Administration has approved two HDAC inhibitors, vorinostat (2006) and romidepsin (2009), for the treatment of cutaneous T-cell lymphoma. This review highlights the safety of HDAC inhibitors currently approved or being investigated for the treatment of hematologic malignancies, with a specific focus on the safety experience with vorinostat in cutaneous T-cell lymphoma. © 2016.

We analyse the light curve in the R band of the blazar OJ287, gathered during the 2015/2016 observing season. We did a search for quasi-periodic oscillations (QPOs) using several methods over a wide range of timescales. No statistically significant periods were found in the high-frequency domain both in the ground-based data and in Kepler observations. In the longer-period domain, the Lomb-Scargle periodogram revealed several peaks above the 99% significance level. The longest one—about 95 days—corresponds to the innermost stable circular orbit (ISCO) period of the more massive black hole. The 43-day period could be an alias, or it can be attributed to accretion in the form of a two-armed spiral wave.

{The objective of this study is the analysis of heavy precipitation events occurred in Attica region during the period 2007-2013, along with the determination of their characteristics depending on the season and their corresponding impact. These events were selected according to two criteria; the lightning occurrence-information that was acquired from the Hellenic National Meteorological Service Precision Lightning Sensors Network (HNMS-PLN)-and the high rainfall intensity, provided by the Hydrological Observatory of Athens (HOA) rainfall network. On the one hand, the composite means and anomalies of the respective synoptic conditions, which were based on the reanalysis data sets acquired from the National Centers for Environmental Prediction-National Center for Atmospheric Research (NCEP-NCAR), along with the frontal activity over Greece, have been analyzed. On the other hand, special attention has been given to the configuration of specific instability indices, during the examined rainfall events. The aforementioned study is an effort to shed light to the rainfall events' features, with respect to their seasonal incidence and their relation to phenomena such as floods and hail.}

Damage scenarios are necessary tools for stakeholders, in order to prepare protection strategies and a total emergency post-earthquake plan. To this aim, four seismic hazard models were developed for the city of Kalamata, according to stochastic simulation of the ground motion, using site amplification functions derived from ambient noise HVSR measurements. The structural vulnerability of the city was assessed following an empirical macroseismic model, developed for the European urban environment (EMS-98). The impact of the vulnerability due to the seismic hazard potential is also investigated by means of synthetic response spectral ratios at 108 sites of the city. The expected damage grade per building block, is calculated by combining vulnerability with the respective seismic intensities, derived for the four seismic sources. The importance of the followed methodology for implementing microzonation studies is emphasized, since the expected influence of the ground motion amplification due to local soil conditions has been approximated in detail. Moreover, new fragility curves for the main structural types in Kalamata are proposed for each seismic scenario.

A catalogue of relocated earthquake hypocenters and focal mechanisms was constructed and evaluated in order to examine the tectonics of the western Hellenic Arc. The major part of the analysed dataset includes seismic activity that was recorded during the last decade. This is due to the occurrence of several moderate to strong earthquakes in the area and to the integration of the Hellenic Unified Seismological Network (HUSN), which provided adequate coverage with high quality waveform records that were analyzed by the Seismological Laboratory ofthe University of Athens. Additionally, phase data available by local networks were employed. The concept of double differences was applied to achieve improved relative hypocentral locations. Relocated seismicity appears concentrated at depths above 25 km, exhibiting spatial continuity along the convergence boundary and being clustered elsewhere. Earthquakes are confined within the accreted sediments escarpment of the down-going African plate against the un-deformed Pindos hinterland.Stress tensor inversion of ~2000 relocated focal mechanisms reveals predominantly strike-slip faulting in NNE-SSW to NE-SW direction and normal faulting in E-W or N-S directions. The heterogeneity of the stress field appears to be unusually high, particularly in the region of the northernmost tip of the Hellenic subduction and in thevicinity of the Cephalonia-Lefkada transform fault zone, an area of high seismic risk that was activated recently, with the generation of two strong earthquakes of Mw=6.1 and 5.9 at the western part of the Cephalonia Island in January-February 2014 and an Mw=6.4 event that occurred onshore SW Lefkada Island in November 2015. The stress field distribution implies that Pindos constitutes a seismic boundary along which large heterogeneities occur. Onshore western Greece, N-S crustal extension dominates, while in central and south Peloponnesus the stress field appears rotated by 90°. Shearing-stress obliquity by 30° is indicated along the major strike-slip faults. At larger depths, within the lower crust, the stress field becomes more homogeneous, consistent with well-known large scale kinematics of the Aegean region.

Multiple myeloma (MM) is a multi-subclonal malignancy with relatively high heterogeneity. Patients who initially presented with both monoclonal-protein (MP) and free light chain (FLC) secretion but then relapsed with a light chain escape pattern have been shown to reflect disease clonal evolution and to bare a worse prognosis. We hypothesized that a discordant MP/FLC pattern at diagnosis may reflect a similar clonal evolution that had occurred prior to diagnosis of active myeloma, conferring a worse outcome. We analyzed 255 consecutive newly diagnosed MM patients who received first line bortezomib-based therapy between 2007 and 2014, hypothesizing that their MP/FLC fingerprint at diagnosis reflects clonal heterogeneity and, therefore, affects outcome. An involved FLC level ≥ 700 mg/L and MP ≥ 2.5 g/L were used as cutoffs for low vs high FLC and MP levels, respectively. Patients were divided into 4 subgroups according to their involved FLC and MP blood levels at diagnosis: HiLC and HiMP for patients with either a predominant FLC or a predominant MP, respectively, and HiLC-MP and LoLC-MP when both FLC and MP were increased or decreased, respectively. There were 68 (27%) patients with HiLC, which presented more often with International Staging System-3 stage (P < .0001). Multivariate analysis showed that HiLC was associated with a 5.1-fold risk for mortality in a multivariate model (95% confidence interval [CI], 1.34-19.68). Both HiLC and HiLC-MP phenotypes were associated with shorter progression-free survival (hazard ratio of 2.66 [95% CI, 1.33-5.32] and 2.82 [95% CI, 1.37-5.83], respectively), independently of other prognostic factors, including the use of autograft. Thus, we identified an LC predominant secretory fingerprint (HiLC phenotype) at diagnosis as a potential independent risk factor that may affect disease control and survival in newly diagnosed MM patients treated with bortezomib-based induction therapy; this may represent increased subclonal heterogeneity. © 2016 John Wiley & Sons, Ltd.

SUMMARY: The purpose of the present study is to define which regions of the cranium, the upper-face, the orbits and the nasal are the most sexually dimorphic, by using three-dimensional geometric morphometric methods, and investigate the effectiveness of this method in determining sex from the shape of these regions. The study sample consisted of 176 crania of known sex (94 males, 82 females) belonging to individuals who lived in Greece during the 20(th) century. The three-dimensional co-ordinates of 31 ecto-cranial landmarks were digitized using a MicroScribe 3DX contact digitizer. Goodall's F-test was performed in order to compare statistical differences in shape between males and females. Generalized Procrustes Analysis (GPA) was used to obtain size and shape variables for statistical analysis. Shape, Size and Form analyses were carried out by logistic regression and discriminant function analysis. The results indicate that there are shape differences between the sexes in the upper-face and the orbits. The highest shape classification rate was obtained from the upper-face region. The centroid size of the caraniofacial and the orbital regions was smaller in females than males. Moreover, it was found that size is significant for sexual dimorphism in the upper-face region. As anticipated, the classification accuracy improves when both size and shape are combined. The findings presented here constitute a firm basis upon which further research can be conducted.

The aim of this study is to assess sexual dimorphism of adult crania in the vault and midsagittal curve of the vault using three-dimensional geometric morphometric methods. The study sample consisted of 176 crania of known sex (94 males, 82 females) belonging to individuals who lived during the 20th century in Greece. The three-dimensional co-ordinates of 31 ecto-cranial landmarks and 30 semi-landmarks were digitized using a MicroScribe 3DX contact digitizer. Generalized Procrustes analysis (GPA) was used to obtain size and shape variables for statistical analysis. Shape, size and form analyses were carried out by logistic regression and three discriminant function analyses. Results indicate that there are shape differences between sexes. Females in the region of the parietal bones are narrower and the axis forming the frontal and occipital bones is more elongated; the frontal bone is more vertical. Sex-specific shape differences give better classification results in the vault (79%) compared with the midsagittal curve of the neurocranium (68.8%). Size alone yielded better results for cranial vault (82%), while for the midsagittal curve of the vault the result is poorer (68.1%). As anticipated, the classification accuracy improves when both size and shape are combined (89.2% for vault, and 79.4% for midsagittal curve of the vault). These latter findings imply that, in contrast to the midsagittal curve of the neurocranium, the shape of the cranial vault can be used as an indicator of sex in the modern Greek population.

OBJECTIVES: This study aimed to quantify the patterns of shape variability and the extent and patterns of shape covariation between the upper and lower dental arch in an orthodontic population. METHODS: Dental casts of 133 white subjects (61 males, 72 females; ages 10.6-26.6) were scanned and digitized in three dimensions. Landmarks were placed on the incisal margins and on the cusps of canines, premolars, and molars. Geometric morphometric methods were applied (Procrustes superimposition and principal component analysis). Sexual dimorphism and allometry were evaluated with permutation tests and age-size and age-shape correlations were computed. Two-block partial least squares analysis was used to assess covariation of shape. RESULTS: The first four principal components represented shape patterns that are often encountered and recognized in clinical practice, accounting for 6-31 per cent of total variance. No shape sexual dimorphism was found, nevertheless, there was statistically significant size difference between males and females. Allometry was statistically significant, but low (upper: R(2) = 0.0528, P < 0.000, lower: R (2) = 0.0587, P < 0.000). Age and shape were weakly correlated (upper: R(2) = 0.0370, P = 0.0001, lower: R (2) = 0.0587, P = 0.0046). Upper and lower arches covaried significantly (RV coefficient: 33 per cent). The main pattern of covariation between the dental arches was arch width (80 per cent of total covariance); the second component related the maxillary canine vertical position to the mandibular canine labiolingual position (11 per cent of total covariance). LIMITATIONS: Results may not be applicable to the general population. Age range was wide and age-related findings are limited by the cross-sectional design. Aetiology of malocclusion was also not considered. CONCLUSIONS: Covariation patterns showed that the dental arches were integrated in width and depth. Integration in the vertical dimension was weak, mainly restricted to maxillary canine position.

The long term change of the shoreline is a phenomenon, which is factored in the design of construction projects along the coastal zone. This study presents a meth-odology that aims to quantify the shoreline displacement rate. The described meth-odology involves the interpretation of different remote sensing data types, which make up a quite dense time series of representations for the coastline spanning from 1987 to 2012. The representation of the shoreline is based on geometrically corrected (ortho-rectified), historical, analogue, panchromatic, high resolution aerial photos of the area (1987, 1996) and latest generation, digital, multispectral, high resolution satellite images (2000, 2008, 2012). In all cases the images were digitally processed and optically optimized in order to produce a highly accurate representation of the shoreline in each time period. All the data were imported in a Geographic Information System platform, where they were subjected to comparison and geo-statistical analysis. A large number of sections perpendicular to the coast (every 100 meters) was drawn and the relative motion of the coastline was calcu-lated for each of them. The average rate of the calculated erosion is in the order of 24mm/year whilst extreme rates of 1m/year were also observed in specific posi-tions.

A thorough study of localized surface plasmons and associated strong circular dichroism, which can occur in silver-coated metallic and dielectric magnetic nanospheres, is reported by means of both quasistatic and full electrodynamic calculations taking into account the actual (magneto) optical response of the constituent materials, including dispersion and losses. It is shown that such composite magnetoplasmonic nanoparticles offer a versatile platform for engineering hybrid plasmon modes that give rise to sharp absorption resonances and subject to large magneto-optic splitting, leading to giant magnetic circular dichroism signals, by properly choosing the different materials and tuning the geometrical parameters involved.

The objective of this paper was to explore whether and how the main capital structure determinants of SMEs affected capital structure determination in different ways during the years of economic crisis. We used panel data of 8,052 SMEs operating in Greece during 2009–2012. We found that the effect of capital structure determinants on leverage does not change in an environment of economic crisis; larger SMEs continued to show higher debt ratios, the relationship between profitability and tangibility of assets with leverage continued to be negative, and growth was positively related to leverage.

Ιn a sample of Turkish adolescents (N = 1614), we investigated whether pursuing social demonstration-approach goals (to attain popularity), next to social development goals (to cultivate meaningful relationships), explains differences in need satisfaction and frustration and coping. Cluster analysis showed that students who favored social development over social demonstration-approach goals reported less need frustration and defensive coping than students who favored both goals. These results were replicated with a prospective analysis with part of the initial sample (N = 425) as students who endorsed both goals reported more defensive coping five months later than students who mainly favored social development goals over social demonstration-approach goals.

BACKGROUND AND AIMS: Over the past two decades there was an upsurge of the use of Internet in human life. With this continuous development, Internet users are able to communicate with any part of the globe, to shop online, to use it as a mean of education, to work remotely and to conduct financial transactions. Unfortunately, this rapid development of the Internet has a detrimental impact in our life, which leads to various phenomena such as cyber bullying, cyber porn, cyber suicide, Internet addiction, social isolation, cyber racism etc. The main purpose of this paper is to record and analyze all these social and psychological effects that appears to users due to the extensive use of the Internet. MATERIALS AND METHODS: This review study was a thorough search of bibliography data conducted through Internet and library research studies. Key words were extracted from search engines and data bases including Google, Yahoo, Scholar Google, PubMed. FINDINGS: The findings of this study showed that the Internet offers a quick access to information and facilitates communication however; it is quite dangerous, especially for young users. For this reason, users should be aware of it and face critically any information that is handed from the website.

Published archaeological, palaeoenvironmental, and palaeoclimatic data from the Peloponnese in Greece are compiled, discussed and evaluated in order to analyse the interactions between humans and the environment over the last 9000 years. Our study indicates that the number of human settlements found scattered over the peninsula have quadrupled from the prehistoric to historical periods and that this evolution occurred over periods of climate change and seismo–tectonic activity. We show that societal development occurs both during periods of harsh as well as favourable climatic conditions. At some times, some settlements develop while others decline. Well-known climate events such as the 4.2 ka and 3.2 ka events are recognizable in some of the palaeoclimatic records and a regional decline in the number and sizes of settlements occurs roughly at the same time, but their precise chronological fit with the archaeological record remains uncertain. Local socio-political processes were probably always the key drivers behind the diverse strategies that human societies took in times of changing climate. The study thus reveals considerable chronological parallels between societal development and palaeoenvironmental records, but also demonstrates the ambiguities in these correspondences and, in doing so, highlights some of the challenges that will face future interdisciplinary projects. We suggest that there can be no general association made between societal expansion phases and periods of advantageous climate. We also propose that the relevance of climatic and environmental regionality, as well as any potential impacts of seismo-tectonics on societal development, need to be part of the interpretative frameworks.

Основание НАТО 4 апреля 1949 года драматическим образом ознаменовало окончательный распад альянса трех великих держав - США, Великобритании и СССР, созданного во время Второй мировой войны. Вместе с тем, это стало началом новой, послевоенной биполярной системе баланса сил, главным проявлением которой стала Холодная война. Это тотальное политическое противостояние между двумя сверхдержавами и их сателлитами, распространившееся на большую часть нашей планеты, началось на послевоенных руинах Старого Света, где столкнулись исторически противоположные геополитические устремления обеих сторон - противостояние, усиленное ростом числа откровенных мистификаций, скрытые мотивов и стереотипов, а также конфликтом национальных интересов. В фундаменте этого противостояния лежат принципы и ценности, с 1945 года взятые Уставом ООН в качестве основы для создания послевоенной международной системы. Главные пункты этого Устава объявляют применение насилия в международных отношениях как способ разрешения международных споров нелегитимным (статьи 2.3 и 2.4), обязывают уважать внутренние дела государства (статья 2.7), а также определяют право государств на индивидуальную или коллективную самооборону (как «соПейме зе!^-сЫепсе») - это определяется в статье 21 Устава ООН (а также, позже, в статье 5 Устава НАТО, и в соответствующих статьях Варшавского договора). Задуманное, как это часто бывает, с благими намерениями, в конце концов все это превратилось в гигантский ком неуверенности, страха и взаимного недоверия, а порой и открытой ненависти с обеих сторон. Первым последствием стало разделение Германии, что придало последующему разделению Европы «официальный». Это стало знаковым событием, обнажившим конфликт интересов между Западом и СССР - блокада Берлина советскими войсками (19481949), после чего было создано НАТО.

Ugo Foscolo, was an Italian poet whose works rank among the masterpieces of Italian literature. Talented and well educated in philosophy, classics, and Italian literature, Foscolo gave literary expression to his ideological aspirations and to the numerous amorous experiences in odes, sonnets, plays, poems and an epistolary novel. Concurrent with his rich literary output, Foscolo’s correspondence represents a unique perspective from which to monitor his literary and political views and investigate aspects of his everyday life. Among other interesting information, one can find elements of Foscolo’s medical history which is generally unknown. In the present article we investigate the possibility that chronic bladder outlet obstruction and the consequent renal insufficiency was attributed to the death of Ugo Foscolo.

Προσκεκλημένη-συμμετοχή στην Ημερίδα Meet up – Κοινωνική Επιχειρηματικότητα Συμβουλές & Σύμβουλοι. «Διαδραστική Συνάντηση Ενδυνάμωσης Δεξιοτήτων». Europe Direct City of Athens, Sesbo-social enterprise skills, IKY,  Funded by Erasmus+ Programme of the European Union, Αθήνα, 25 Οκτωβρίου 2016.

Στον ελληνικό περιοδικό τύπο του 19ου αιώνα κυριαρχεί η αρθρογραφία για την Ελληνική αρχαιότητα αντανακλώντας το φλέγον ζητούμενο της εποχής, τη σύνδεση του νεώτερου Ελληνισμού με την ελληνική αρχαιότητα, με σκοπό την δημιουργία μιας εθνικής ταυτότητας, την πολυπόθητη διαμόρφωση της εθνικής συνείδησης, συνυφασμένη με τον ευρωπαϊσμό. Η ελληνική αρχαιότητα αποκαλύπτεται στους φιλομαθείς του νεοσύστατου κρατιδίου μέσα από τις μεταφράσεις άρθρων των αρχαιολατρών μελετητών της Δύσης. Ήδη από τα μέσα του 18ου αι. η δυτική αρχαιοφιλία απασχολείται συστηματικά με όλες τις εκφάνσεις του αρχαιοελληνικού πολιτισμού, τις οποίες –ως επακόλουθο- ενσωματώνει στη σύγχρονη ευρωπαϊκή σκέψη και πνευματική δημιουργία, παράγοντας διακείμενα σε όλους τους τομείς των γραμμάτων και των τεχνών (φιλοσοφία, λογοτεχνία, θέατρο, μουσική, καλές τέχνες, αρχιτεκτονική). Το άρθρο πραγματεύεται μία δημοσίευση στην Ιωνική Μέλισσα στις 16/11/1850, το οποίο τιτλοφορείται «Οιδίπους Τύραννος» και υπογράφεται από τον «Πείσανδρο», πιθανό ψευδώνυμο –δίχως να έχει επιβεβαιωθεί η πληροφορία- του Ικέσιου Λάτρη (1799 - 1881), Σμυρναίου λόγιου, αγωνιστή του 1821 και πολιτικού της νεοσύστατης Ελλάδας. Στο εν λόγω άρθρο, το οποίο αναφέρεται στα θέματα της πρόσληψης του αρχαίου θεάτρου, αναπτύσσεται ένας πρώιμος προβληματισμός, για τον οποίον όμως προτάσσονται λύσεις και περιγράφεται ο τρόπος υλοποίησης μίας πολιτικής στρατηγικής.

Talented and well educated in philosophy, classics and Italian literature, Foscolo gave literary expression to his ideological aspirations and to his numerous amorous experiences in odes, sonnets, plays, poems and an epistolary novel. Concurrent with his rich literary output, Foscolo's correspondence represents a unique perspective from which to monitor his literary and political views and investigate aspects of his everyday life. Among other interesting information, one can find elements of Foscolo medical history which is generally unknown. In the present article we investigate the longstanding lower urinary tract symptoms as reported by the poet in his correspondence to his family and friends.

We analyzed a large number of focal mechanisms and relocated earthquake hypocenters to investigate the geodynamics of western Greece, the most seismically active part of the Aegean plate-boundary zone. This region was seismically activated multiple times during the last decade, providing a large amount of enhanced quality new information that was obtained by the Hellenic Unified Seismological Network (HUSN). Relocated seismicity using a double-difference method appears to be concentrated above ∼35 km depth, exhibiting spatial continuity along the convergence boundary and being clustered elsewhere. Earthquakes are confined within the accreted sediments escarpment of the down-going African plate against the un-deformed Eurasian hinterland. The data arrangement shows that Pindos constitutes a seismic boundary along which large stress heterogeneities occur. In Cephalonia no seismicity is found to be related with the offshore Cephalonia Transform Fault (CTF). Onshore, NS crustal extension dominates, while in central and south Peloponnesus the stress field appears rotated by 90°. Shearing-stress obliquity by 30° is indicated along the major strike-slip faults, consistent with clockwise crustal rotation. Within the lower crust, the stress field appears affected by plate kinematics and distributed deformation of the lower crust and upper mantle, which guide the regional geodynamics.

Using the Boltzmann formalism based on the first principles electronic structure and scattering rates, we investigate the current-induced spin accumulation and spin-orbit torques in FePt/Pt and Co/Cu bilayers in the presence of substitutional impurities. In FePt/Pt bilayers we consider the effect of intermixing of Fe and Pt atoms in the FePt layer and find a crucial dependence of spin accumulation and spin-orbit torques on the details of the distribution of these defects. In Co/Cu bilayers we predict that the magnitude and sign of the spin-orbit torque and spin accumulation depend very sensitively on the type of the impurities used to dope the Cu substrate. Moreover, simultaneously with impurity-driven scattering, we consider the effect of an additional constant quasiparticle broadening of the states at the Fermi surface to simulate phonon scattering at room temperature and discover that even a small broadening of the order of 25 meV can drastically influence the magnitude of the considered effects. We explain our findings based on the analysis of the complex interplay of several competing Fermi surface contributions to the spin accumulation and spin-orbit torques in these structurally and chemically nonuniform systems.

We explain and motivate Stefan–Sussmann singular foliations, and by replacing the tangent bundle of a manifold with an arbitrary Lie algebroid, we introduce singular subalgebroids. Both notions are defined using compactly supported sections. The main results of this note are an equivalent characterization, in which the compact support condition is removed, and an explicit description of the sheaf associated to any Stefan–Sussmann singular foliation or singular subalgebroid.

The synthesis and molecular structures of a U(v) neutral terminal oxo complex and a U(v) sodium uranium nitride contact ion pair are described. The synthesis of the former is achieved by the use of tBuNCO as a mild oxygen transfer reagent, whilst that of the latter is via the reduction of NaN3. Both mono-uranium complexes are stabilised by the presence of bulky silyl substituents on the ligand framework that facilitate a 2e- oxidation of a single U(iii) centre. In contrast, when steric hindrance around the metal centre is reduced by the use of less bulky silyl groups, the products are di-uranium, U(iv) bridging oxo and (anionic) nitride complexes, resulting from 1e- oxidations of two U(iii) centres. SQUID magnetometry supports the formal oxidation states of the reported complexes. Electrochemical studies show that the U(v) terminal oxo complex can be reduced and the [U(iv)O]- anion was accessed via reduction with K/Hg, and structurally characterised. Both the nitride complexes display complex electrochemical behaviour but each exhibits a quasi-reversible oxidation at ca. -1.6 V vs. Fc+/0.

We consider a fluid queue with two modes of service, that represents a production facility, where the processing of the customers (units) is typically carried out at a much faster time-scale than the machine-related processes. We examine the strategic behavior of the customers, regarding the joining/balking dilemma, under two levels of information upon arrival. Specifically, just after arriving and before making the decision, a customer observes the level of the fluid, but may or may not get informed about the state of the server (fast/slow). Assuming that the customers evaluate their utilities based on a natural reward/cost structure, which incorporates their desire for processing and their unwillingness to wait, we derive symmetric equilibrium strategy profiles. Moreover, we illustrate various effects of the information level on the strategic behavior of the customers. The corresponding social optimization problem is also studied and the inefficiency of the equilibrium strategies is quantified via the Price of Anarchy (PoA) measure.

This article explores patterns of accentuation that are profoundly af- fected by the morphosyntactic structure and, especially, by the way the constituents of a word are assembled and concomitantly processed by the PF component. We first review well-known cases of stress-affecting affixation in English from various theoretical perspectives in order to discover key aspects of the architectural and/or lexical item-specific conditions that instigate accentual dominance, that is, the attraction of stress by certain morphological constituents. We propose a path of analysis along the lines of Embick’s (2014) phase-based approach to the morphosyntax/phonology interface, according to which the ability of the exponent of a morpheme to trigger a cyclic phonological rule (phonological cyclicity) is dissociated from the phase status of the morpheme (phase cyclicity) and becomes an unpredictable property of its exponent. Based on an examination of the more intricate pat- terns of accentual dominance exhibited by a group of lexical stress systems—namely Greek, Vedic Sanskrit and Yakima Sahaptin—we propose that dominance emanates from both the architectural properties of the Grammar and the idiosyncratic lexical properties of the exponents of the morphosyntactic constituents, but not in a totally arbitrary way as predicted by Embick’s approach. Notably, our study reveals that a set of significant, so far unnoticed, implicational relations between phasehood and phonological cyclicity apply: No system has dominant exponents of non-phase heads without having dominant exponents of phase heads; and, moreover, no system has dominant accentless exponents without having dominant accented ones.

Although its involvement in prion replication and neurotoxicity during transmissible spongiform encephalopathies is undisputed, the physiological role of the cellular prion protein (PrP(C)) remains enigmatic. A plethora of functions have been ascribed to PrP(C) based on phenotypes of Prnp(-/-) mice. However, all currently available Prnp(-/-) lines were generated in embryonic stem cells from the 129 strain of the laboratory mouse and mostly crossed to non-129 strains. Therefore, Prnp-linked loci polymorphic between 129 and the backcrossing strain resulted in systematic genetic confounders and led to erroneous conclusions. We used TALEN-mediated genome editing in fertilized mouse oocytes to create the Zurich-3 (ZH3) Prnp-ablated allele on a pure C57BL/6J genetic background. Genomic, transcriptional, and phenotypic characterization of Prnp(ZH3/ZH3) mice failed to identify phenotypes previously described in non-co-isogenic Prnp(-/-) mice. However, aged Prnp(ZH3/ZH3) mice developed a chronic demyelinating peripheral neuropathy, confirming the crucial involvement of PrP(C) in peripheral myelin maintenance. This new line represents a rigorous genetic resource for studying the role of PrP(C) in physiology and disease.

We have continued monitoring the blazar OJ287 in the optical at several sites after its November/December, 2015 outburst. After a further large outburst that started in the beginning of February, 2016 (Atels #8667, #8697, #8705) OJ287 remained brighter than 14th magnitude [in R] for the rest of the month.

Spin dephasing by the Dyakonov-Perel mechanism in metallic films deposited on insulating substrates is revealed, and quantitatively examined by means of density functional calculations combined with a kinetic equation. The surface-to-substrate asymmetry, probed by the metal wave functions in thin films, is found to produce strong spin-orbit fields and a fast Larmor precession, giving a dominant contribution to spin decay over the Elliott-Yafet spin relaxation up to a thickness of 70 nm. The spin dephasing is oscillatory in time with a rapid (subpicosecond) initial decay. However, parts of the Fermi surface act as spin traps, causing a persistent tail signal lasting 1000 times longer than the initial decay time. It is also found that the decay depends on the direction of the initial spin polarization, resulting in a spin-dephasing anisotropy of 200% in the examined cases.

The methodological foundations of mainstream economics have been cited as one of the main reasons for its failure to account for the economic crisis of 2008. In spite of this, the status of economic methodology has not been elevated. It is argued that this is due to the persistent aversion towards methodological discourse by most mainstream economists. This attitude has a long presence as exemplified in Frank Hahn’s (1992) work. After focusing on the debate originating after the publication of Hahn’s arguments, the paper offers a categorization of the main explanations for mainstream methodological aversion. Subsequently, it suggests an explanation based on the role of the physics scientific ideal, arguing that the endeavour to achieve the high scientific status of physics by following the methods of physics, contributed to the negative mainstream attitude towards economic methodology. The relevant writings of the extremely influential mainstream economists Irwin Fisher and Milton Friedman, reinforce the assertion that the alleged hard science status of economics renders methodological discussions and especially methodological criticism, rather pointless. The paper also calls for a more systematic discussion of this issue, especially in the wake of the line of argument that links the recent failings of mainstream to its methodological basis

The uric acid/xanthine H(+) symporter, UapA, is a high-affinity purine transporter from the filamentous fungus Aspergillus nidulans. Here we present the crystal structure of a genetically stabilized version of UapA (UapA-G411VΔ1-11) in complex with xanthine. UapA is formed from two domains, a core domain and a gate domain, similar to the previously solved uracil transporter UraA, which belongs to the same family. The structure shows UapA in an inward-facing conformation with xanthine bound to residues in the core domain. Unlike UraA, which was observed to be a monomer, UapA forms a dimer in the crystals with dimer interactions formed exclusively through the gate domain. Analysis of dominant negative mutants is consistent with dimerization playing a key role in transport. We postulate that UapA uses an elevator transport mechanism likely to be shared with other structurally homologous transporters including anion exchangers and prestin.

Performance at school is affected not only by students' achievement goals but also by emotional exchanges among classmates and their teacher. In this study, we investigated relationships between students' achievement goals and emotion perception ability and class affect and performance. Participants were 949 Greek adolescent students in 49 classes and their Greek language and mathematics teachers. Results from multilevel analyses indicated that students' mastery-approach and performance-approach goals were positively related to positive affect whereas performance-avoidance goals were negatively related to positive affect. At class-level, relationships between achievement goals and affect were moderated by students' emotion perception ability. These findings highlight the importance of emotion abilities and their role in motivational processes for class-level outcomes.

Sea level indicators, such as tidal notches and beachrocks, may provide valuable information for the relative sea level changes of an area. Beachrocks in particular have received various arguments concerning their use as reliable sea level indicators and their formation environment. This work focuses on the coasts of East Attica in order to trace the palaeoshorelines of the Upper Holocene through the study of beachrocks. The coastal zone was surveyed in detail by snorkelling and diving, in order to locate, map and sample beachrocks. The samples were studied under a SEM, which showed that the beachrocks are mainly composed of quartz grains, a few calcites and feldspars, while the carbonate cement is characterized with the presence of MgO at percentages between 5 and 7.8%. Based on correlations with published drillings in the study area, the studied beachrocks should not be older than 2000 years BP.

As a geographical method of analyzing power redistribution, Systemic GeopoliticalAnalysis (according to Ioannis Th. Mazis theoretical basis) proposes a multi-dimensional, interdisciplinary research pattern, which embraces economic, cultural, political and defensive facts. The amount of data produced combining these attributes is extremely large and complex. One of the solutions to explore and analyze this data is clustering it. In this work, two clustering algorithms were used, namely DBSCAN and the k-means techniques which both of them cluster data according to its characteristics. While DBSCAN groups data based on the minimum size of participating objects per cluster and the minimum required distance between them, k-means clusters the data objects according the pre-desired number of groups. Thus, since the two methods use different roads to group the data objects, they form different clusters but each one has its importance depending on the characteristics of the applied method. As a result, in this work a comparative study is presented.

Abstract The differential cross sections of the 2125 keV $\gamma$–ray, emitted by the $^{11}$B(p, p'$\gamma$)$^{11}$B reaction were measured at six (6) angles and at proton energies from 2.5 to 5.0 MeV. The experimental setup consisted of three (3) 100% relative efficiency \{HPGe\} detectors placed on a motorized turntable. The comparison between the present measurements, which have an overall uncertainty of $\sim$8%, and previous ones from literature gives contradictory results. While there are large differences with previous differential cross-section measurements from literature, there is good agreement with previous thick-target yield ones. Additional thick-target measurements were performed in an effort to explain the observed discrepancies.

Magnetoresistance effects observed in superconductor/ferromagnet (SC/FM) hybrids, SC/FM bilayers and FM/SC/FM trilayers, have attracted much interest in recent years. Here we focus on the stray-fields-based superconducting magnetoresistance effect (sMRE) observed in Co(d(Co))/Nb(d(Nb))/Co(d(Co)) trilayers with sufficiently thick Co outer layers so that out-of-plane magnetic domains (MDs) and MDs walls (MDWs) emerge all over their surface when subjected to a parallel external magnetic field, H-ex equal to the coercive field, H-c. Asking for the optimum conditions to maximize the sMRE, we explore the interference between three basic length scales of the SC and FM structural units: the thickness of the SC interlayer (d(SC)), the zero-temperature coherence length (xi(0)) and the width of out-of-plane MDs (D-MDs). To this effect, simulations-based modeling of the transverse stray dipolar fields, H-z,H-dip that emerge at the interior of the out-of-plane MDs is performed. Both cases of homogeneous and inhomogeneous micromagnetic characteristics (saturation magnetization, M-sat and width, DMDs) of the out-of-plane MDs are investigated. Furthermore, the influence of the microstructure of the bottom and top Co layers on the macroscopic coercive field of the TLs is addressed. The obtained modeling results respond well when tested against experimental data. The generic criteria reported here on the optimum matching of d(SC), xi(0) and D-MDs aiming to maximize the sMRE magnitude in relevant FM/SC/FM trilayers, can assist the design of relevant cryogenic devices. (C) 2016 Elsevier B.V. All rights reserved.

Recently it has been shown that surface magnetic doping of topological insulators induces backscattering of Dirac states which are usually protected by time-reversal symmetry {[}Sessi et al., Nat. Commun. 5, 5349 (2014)]. Here we report on quasiparticle interference measurements where, by improved Fermi level tuning, strongly focused interference patterns on surface Mn-doped Bi2Te3 could be directly observed by means of scanning tunneling microscopy at 4 K. Ab initio and model calculations reveal that their mesoscopic coherence relies on two prerequisites: (i) a hexagonal Fermi surface with large parallel segments (nesting) and (ii) magnetic dopants which couple to a high-spin state. Indeed, x-ray magnetic circular dichroism shows superparamagnetism even at very dilute Mn concentrations. Our findings provide evidence of strongly anisotropic Dirac-fermion-mediated interactions and demonstrate how spin information can be transmitted over long distances, allowing the design of experiments and devices based on coherent quantum effects in topological insulators.

Zinc oxide (ZnO) is an important material for polymer solar cells (PSCs) where the characteristics of the interface can dominate both the efficiency and lifetime of the device. In this work we study the effect of fluorine (SF6) plasma surface treatment of ZnO films on the performance of PSCs with an inverted structure. The interaction between fluorine species present in the SF6 plasma and the ZnO surface is also investigated in detail. We provide fundamental insights into the passivation effect of fluorine by analyzing our experimental results and theoretical calculations and we propose a mechanism according to which a fluorine atom substitutes an oxygen atom or occupies an oxygen vacancy site eliminating an electron trap while it may also attract hydrogen atoms thus favoring hydrogen doping. These multiple fluorine roles can reduce both the recombination losses and the electron extraction barrier at the ZnO/fullerene interface improving the selectivity of the cathode contact. Therefore, the fabricated devices using the fluorine plasma treated ZnO show high efficiency and stable characteristics, irrespective of the donor:acceptor combinations in the photoactive blend. Inverted polymer solar cells, consisting of the P3HT:PC71BM blend, exhibited increased lifetime and high power conversion efficiency (PCE) of 4.6%, while the ones with the PCDTBT:PC71BM blend exhibited a PCE of 6.9%. Our champion devices with the PTB7:PC71BM blends reached a high PCE of 8.0% and simultaneously showed exceptional environmental stability when using the fluorine passivated ZnO cathode interlayers. © The Royal Society of Chemistry 2016.

PSR J1119-6127 is a rotationally-powered (RP) pulsar whose pulsations are detected in radio, X-rays and gamma-rays. It is a high magnetic field neutron star, with an inferred dipole field strength of about 4 & sdot;1013 G. On July 27 it exhibited a strong X-ray burst, detected by Swift/BAT (ATel #9274) and Fermi/GBM (GCN Circular #19736).

Nanogels based on biocompatible, dual pH- and temperature-sensitive poly(2-(diethylamino)ethyl) methacrylate (PDEAEMA) have been successfully used as nanocontainers for the encapsulation of magnetite, Fe3O4 magnetic nanoparticles (MNPs). For this purpose, citric acid-coated MNPs were encapsulated into previously synthesized PDEAEMA-based nanogels using a poly(ethyleneglycol)-based stabilizer. After the encapsulation of the magnetite MNPs, the so-called magneto-nanogels (MNGs) were proved to be multiresponsive on temperature, pH, and magnetic field and colloidally stable. Moreover, preliminary studies on the biocompatibility of these MNGs with cells of human peripheral blood were performed and evidenced quite tolerable biocompatibility, thus suggesting potential use in biomedical applications. (C) 2015 Wiley Periodicals, Inc.

Exposure to chronic stress is frequently accompanied by cognitive and affective disorders in association with neurostructural adaptations. Chronic stress was previously shown to trigger Alzheimer's-like neuropathology, which is characterized by Tau hyperphosphorylation and missorting into dendritic spines followed by memory deficits. Here, we demonstrate that stress-driven hippocampal deficits in wild-type mice are accompanied by synaptic missorting of Tau and enhanced Fyn/GluN2B-driven synaptic signaling. In contrast, mice lacking Tau [Tau knockout (Tau-KO) mice] do not exhibit stress-induced pathological behaviors and atrophy of hippocampal dendrites or deficits of hippocampal connectivity. These findings implicate Tau as an essential mediator of the adverse effects of stress on brain structure and function.

Exposure to chronic stress is frequently accompanied by cognitive and affective disorders in association with neurostructural adaptations. Chronic stress was previously shown to trigger Alzheimer's-like neuropathology, which is characterized by Tau hyperphosphorylation and missorting into dendritic spines followed by memory deficits. Here, we demonstrate that stress-driven hippocampal deficits in wild-type mice are accompanied by synaptic missorting of Tau and enhanced Fyn/GluN2B-driven synaptic signaling. In contrast, mice lacking Tau [Tau knockout (Tau-KO) mice] do not exhibit stress-induced pathological behaviors and atrophy of hippocampal dendrites or deficits of hippocampal connectivity. These findings implicate Tau as an essential mediator of the adverse effects of stress on brain structure and function.

The aim of this paper is to show that the knowledge of the history of Greek after the New Testament and the knowledge of its outcome, i.e. Modern Greek, can provide the tools for a better understanding of some of the linguistic problems presented by New Testament Greek. The testing ground for this claim will be aspect and its relationship to Aktionsart and tense. The paper starts with a brief overview of the Modern Greek verbal system in comparison to the Classical Greek verb, continues with a brief discussion of a theoretical approach to tense and aspect and its application to Modern Greek, and proceeds retrospectively, examining the situation in Early, Classical and New Testament Greek in the light of the Modern Greek data .

Vito Acconci’s early artistic practice combines textuality, visuality, and the involvement with the physical body. It also revolves around the tension between the transience of the performance and the various forms with which the artist’s activities have been devised, recorded, and documented. The voluminous archive that was assembled by Gregory Volk in the Diary of a Body 1969-1973 is worth examining in that respect, since these visual and verbal documents are not only secondary to the event, but make up an integral part of the artist’s early work. Therefore this essay revisits Vito Acconci’s notes and photographs as an assemblage that preserves the experiential substance of the artist’s practice, and also speaks of its in/transitive character, inviting reflection on the connections between writing, performance, and the ground of experience. A paratext to the performances and a continuation of his early writings, the diary is a storehouse that has a documentary value against the grain, which the essay dwells on.

Blazars, a subclass of active galactic nuclei, are prime candidate sources for the high energy neutrinos recently detected by IceCube. Being one of the brightest sources in the extragalactic X-ray and γ-ray sky as well as one of the nearest blazars to Earth, Mrk 421 is an excellent source for testing the scenario of the blazar-neutrino connection, especially during flares where time-dependent neutrino searches may have a higher detection probability. Here, we model the spectral energy distribution of Mrk 421 during a 13-day flare in 2010 with unprecedented multi-wavelength coverage, and calculate the respective neutrino flux. We find a correlation between the >1 PeV neutrino and photon fluxes, in all energy bands. Using typical IceCube through-going muon event samples with good angular resolution and high statistics, wederive the mean event rate above 100 TeV (∼0.57 evt/yr) and show that it is comparable to that expected from a four-month quiescent period in 2009. Due to the short duration of the flare, an accumulation of similar flares over several years would be necessary to produce a meaningful signal for IceCube. To better assess this, we apply the correlation between the neutrino and γ-ray fluxes to the 6.9 yr Fermi-LAT light curve of Mrk 421. We find that the mean event count above 1 PeV for the full IceCube detector livetime is 3.59 ± 0.60 (2.73 ± 0.38) νμ +νbarμ with (without) major flares included in our analysis. This estimate exceeds, within the uncertainties, the 95% (90%) threshold value for the detection of one or more muon (anti-)neutrinos. Meanwhile, the most conservative scenario, where no correlation of γ-rays and neutrinos is assumed, predicts 1.60 ± 0.16νμ +νbarμ events. We conclude that a non-detection of high-energy neutrinos by IceCube would probe the neutrino/γ-ray flux correlation during major flares or/and the hadronic contribution to the blazar emission.

Myeloma cells thrive in an environment of sustained inflammation, which impacts the development and evolution of the disease, as well as drug resistance. We evaluated the impact of genetic polymorphisms in the Toll-like receptor 4 (TLR4) pathway, which have been implicated in different inflammatory responses in the outcomes of patients with symptomatic multiple myeloma (MM) who have received contemporary therapies. We found that the presence of single nucleotide polymorphisms (SNPs) in both the TLR4 and toll/interleukin-1 receptor (TIR)-associated protein (TIRAP) genes was associated with lower response to primary therapy mainly for patients who received immunomodulatory drugs but not in patients treated with bortezomib-based therapies. Furthermore, TIRAP SNP was associated with a significantly shorter progression-free survival and overall survival, independently of other prognostic factors, such as age, transplant, International Staging System stage, lactate dehydrogenase and cytogenetics. This is the first study to demonstrate the effect of SNPs in TLR4/TIRAP in MM. Our data indicate that genetic variability in the immune system may be associated with different responses to antimyeloma therapies and may be a critical component affecting the natural history of the disease, providing the basis for further investigation of the role of these pathways in myeloma. © 2016 John Wiley & Sons Ltd.

BACKGROUND: Despite recent advances the pathogenesis of Crohn's disease remains incompletely understood. A variety of animal models have been utilized in an effort to provide further insights and develop more therapeutic options. In order to simulate, to an extent, the pathogenesis and the clinical course of the disease, TNBS induced colitis is often used. Various approaches for inducing TNBS -colitis have been described in the literature. METHODS/RESULTS: In this review, we sought to present the animal model of TNBS induced colitis and outline the pathogenesis, pathophysiology, clinical course and pathological characteristics of the model. Furthermore, we describe the differences among those protocols regarding types of animals and colitis induction. DATA SOURCES: The MEDLINE database was thoroughly searched using the keywords: TNBS, colitis, Crohn's disease, animal model. Two investigators independently reviewed the abstracts and appropriate articles were included in this review. Additional articles were gathered and evaluated. CONCLUSION: The aim of this study was to thoroughly present an updated review of the TNBS-induced colitis protocols that are implemented by researchers.

Background: We investigated the impact of PIK3CA and TP53 mutations and p53 protein status on the outcome of patients who had been treated with adjuvant anthracycline-taxane chemotherapy within clinical trials in the pre- and post-trastuzumab era. Results: TP53 and PIK3CA mutations were found in 380 (21.5%) and 458 (25.9%) cases, respectively, including 104 (5.9%) co-mutated tumors; p53 immunopositivity was observed in 848 tumors (53.5%). TP53 mutations (p < 0.001) and p53 protein positivity (p = 0.001) were more frequent in HER2-positive and triple negative (TNBC) tumors, while PIK3CA mutations were more frequent in Luminal A/B tumors (p < 0.001). TP53 mutation status and p53 protein expression but not PIK3CA mutation status interacted with trastuzumab treatment for disease-free survival; patients with tumors bearing TP53 mutations or immunopositive for p53 protein fared better when treated with trastuzumab, while among patients treated with trastuzumab those with the above characteristics fared best (interaction p = 0.017 for mutations; p = 0.015 for IHC). Upon multivariate analysis the above interactions remained significant in HER2-positive patients; in the entire cohort, TP53 mutations were unfavorable in patients with Luminal A/B (p = 0.003) and TNBC (p = 0.025); p53 immunopositivity was strongly favorable in patients treated with trastuzumab (p = 0.009). Materials and Methods: TP53 and PIK3CA mutation status was examined in 1766 paraffin tumor DNA samples with informative semiconductor sequencing results. Among these, 1585 cases were also informative for p53 protein status assessed by immunohistochemistry (IHC; 10% positivity cut-off). Conclusions: TP53 mutations confer unfavorable prognosis in patients with Luminal A/B and TNBC tumors, while p53 immunopositivity may predict for trastuzumab benefit in the adjuvant setting.

Background: We investigated the impact of PIK3CA and TP53 mutations and p53 protein status on the outcome of patients who had been treated with adjuvant anthracycline-taxane chemotherapy within clinical trials in the pre- and post-trastuzumab era. Results: TP53 and PIK3CA mutations were found in 380 (21.5%) and 458 (25.9%) cases, respectively, including 104 (5.9%) co-mutated tumors; p53 immunopositivity was observed in 848 tumors (53.5%). TP53 mutations (p < 0.001) and p53 protein positivity (p = 0.001) were more frequent in HER2-positive and triple negative (TNBC) tumors, while PIK3CA mutations were more frequent in Luminal A/B tumors (p < 0.001). TP53 mutation status and p53 protein expression but not PIK3CA mutation status interacted with trastuzumab treatment for disease-free survival; patients with tumors bearing TP53 mutations or immunopositive for p53 protein fared better when treated with trastuzumab, while among patients treated with trastuzumab those with the above characteristics fared best (interaction p = 0.017 for mutations; p = 0.015 for IHC). Upon multivariate analysis the above interactions remained significant in HER2-positive patients; in the entire cohort, TP53 mutations were unfavorable in patients with Luminal A/B (p = 0.003) and TNBC (p = 0.025); p53 immunopositivity was strongly favorable in patients treated with trastuzumab (p = 0.009). Materials and Methods: TP53 and PIK3CA mutation status was examined in 1766 paraffin tumor DNA samples with informative semiconductor sequencing results. Among these, 1585 cases were also informative for p53 protein status assessed by immunohistochemistry (IHC; 10% positivity cut-off). Conclusions: TP53 mutations confer unfavorable prognosis in patients with Luminal A/B and TNBC tumors, while p53 immunopositivity may predict for trastuzumab benefit in the adjuvant setting.

BACKGROUND: Numerous studies have shown that baseline drug resistance patterns may influence the outcome of antiretroviral therapy. Therefore, guidelines recommend drug resistance testing to guide the choice of initial regimen. In addition to optimizing individual patient management, these baseline resistance data enable transmitted drug resistance (TDR) to be surveyed for public health purposes. The SPREAD program systematically collects data to gain insight into TDR occurring in Europe since 2001. METHODS: Demographic, clinical, and virological data from 4140 antiretroviral-naive human immunodeficiency virus (HIV)-infected individuals from 26 countries who were newly diagnosed between 2008 and 2010 were analyzed. Evidence of TDR was defined using the WHO list for surveillance of drug resistance mutations. Prevalence of TDR was assessed over time by comparing the results to SPREAD data from 2002 to 2007. Baseline susceptibility to antiretroviral drugs was predicted using the Stanford HIVdb program version 7.0. RESULTS: The overall prevalence of TDR did not change significantly over time and was 8.3% (95% confidence interval, 7.2%-9.5%) in 2008-2010. The most frequent indicators of TDR were nucleoside reverse transcriptase inhibitor (NRTI) mutations (4.5%), followed by nonnucleoside reverse transcriptase inhibitor (NNRTI) mutations (2.9%) and protease inhibitor mutations (2.0%). Baseline mutations were most predictive of reduced susceptibility to initial NNRTI-based regimens: 4.5% and 6.5% of patient isolates were predicted to have resistance to regimens containing efavirenz or rilpivirine, respectively, independent of current NRTI backbones. CONCLUSIONS: Although TDR was highest for NRTIs, the impact of baseline drug resistance patterns on susceptibility was largest for NNRTIs. The prevalence of TDR assessed by epidemiological surveys does not clearly indicate to what degree susceptibility to different drug classes is affected.

Waldenström macroglobulinemia (WM) is a distinct B-cell lymphoproliferative disorder for which clearly defined criteria for the diagnosis, initiation of therapy, and treatment strategy have been proposed as part of the consensus panels of the International Workshop on Waldenström's Macroglobulinemia (IWWM). At IWWM-8, a task force for treatment recommendations was impanelled to review recently published and ongoing clinical trial data as well as the impact of new mutations (MYD88 and CXCR4) on treatment decisions, indications for B-cell receptor and proteasome inhibitors, and future clinical trial initiatives for WM patients. The panel concluded that therapeutic strategies in WM should be based on individual patient and disease characteristics. Chemoimmunotherapy combinations with rituximab and cyclophosphamide-dexamethasone, bendamustine, or bortezomib-dexamethasone provide durable responses and are still indicated in most patients. Approval of the BTK inhibitor ibrutinib in the United States and Europe represents a novel and effective treatment option for both treatment-naive and relapsing patients. Other B-cell receptor inhibitors, second-generation proteasome inhibitors (eg, carfilzomib), and mammalian target of rapamycin inhibitors are promising and may increase future treatment options. Active enrollment in clinical trials whenever possible was endorsed by the panel for most patients with WM. © 2016 by The American Society of Hematology.

Waldenström macroglobulinemia (WM) is a distinct B-cell lymphoproliferative disorder for which clearly defined criteria for the diagnosis, initiation of therapy, and treatment strategy have been proposed as part of the consensus panels of the International Workshop on Waldenström's Macroglobulinemia (IWWM). At IWWM-8, a task force for treatment recommendations was impanelled to review recently published and ongoing clinical trial data as well as the impact of new mutations (MYD88 and CXCR4) on treatment decisions, indications for B-cell receptor and proteasome inhibitors, and future clinical trial initiatives for WM patients. The panel concluded that therapeutic strategies in WM should be based on individual patient and disease characteristics. Chemoimmunotherapy combinations with rituximab and cyclophosphamide-dexamethasone, bendamustine, or bortezomib-dexamethasone provide durable responses and are still indicated in most patients. Approval of the BTK inhibitor ibrutinib in the United States and Europe represents a novel and effective treatment option for both treatment-naive and relapsing patients. Other B-cell receptor inhibitors, second-generation proteasome inhibitors (eg, carfilzomib), and mammalian target of rapamycin inhibitors are promising and may increase future treatment options. Active enrollment in clinical trials whenever possible was endorsed by the panel for most patients with WM. © 2016 by The American Society of Hematology.

Dr. Willy Lens, born on December 10th, 1943, passed away on August 29th, 2014. With his passing, the motivation community has lost a seminal member, a mentor, and a friend. Dr. Lens - a Fellow of the Association for Psychological Science and Founding Fellow of the American Educational Research Association - made fundamental contributions to the study of motivation both through his own work and through his caring and thoughtful mentorship of a large community of scholars. With this tribute, we want to honor Dr. Willy Lens' significance to psychology and education as well as his positive influence, both personally and professionally, on the lives of dozens of scholars. With his contagious enthusiasm and caring mentorship, Willy was an example for our academic community and with this tribute we express our gratitude for the privilege to have collaborated with him. © 2016 The Author(s).

A novel hydrocarbon-soluble trifunctional organolithium initiator, with no polar-additive requirements, has been synthesized for use in anionic polymerization. The complete synthesis of the unsaturated tri-diphenylethylene compound, 4,4,4-(ethane-1,1,1-triyl)tris(((3-(1-phenylvinyl)benzyl)oxy)benzene) (I), is described and the efficiency of the new initiator is evaluated using 1H NMR and Nano-assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (NALDI-TOF MS). Activation of precursor I, was performed in situ using stoichiometric amounts of sec-BuLi in benzene. Three-arm polystyrene and polyisoprene stars with narrow molecular weight distributions were obtained in the case of relatively high total anion concentration, [sec-BuLi]0 > 3.8 × 10−3 mol L−1 (3 × [I]0). At low total anion concentrations, uncontrolled molecular weight and broad/bimodal distributions were obtained, plausibly attributed to the presence of partially solvated aggregation dynamics complicating the propagation. The ‘living’ nature of the polymerization was confirmed by the sequential polymerization of styrene, and isoprene. The viscometric branching factor g’ values of the final branched polymers were measured and compared to g’ values of three-arm stars reported in the literature.

We report on a 20-fold enhancement of the integrated photoluminescence (PL) emission of silicon nanocrystals, embedded in a matrix of silicon dioxide, induced by excited surface plasmons from silver nanoparticles, which are located in the vicinity of the silicon nanocrystals and separated from them by a silicon dioxide layer of a few nanometers. The electric field enhancement provided by the excited surface plasmons increases the absorption cross section and the emission rate of the nearby silicon nanocrystals, resulting in the observed enhancement of the photoluminescence, mainly attributed to a 20-fold enhancement in the emission rate of the silicon nanocrystals. The observed remarkable improvement of the PL emission makes silicon nanocrystals very useful material for photonic, sensor and solar cell applications. © 2015 Elsevier B.V.

Purpose: Following the establishment of adjuvant carboplatin in stage I testicular seminoma as a standard, we adopted this treatment for all stage I seminoma patients. We report our 8-year experience and compare these results with our previous adjuvant etoposide/cisplatin (EP) strategy. Patients and methods: Patients with stage I seminoma, treated with adjuvant carboplatin and with a minimum follow-up of 1 year, were included. Two cycles of carboplatin [area under the curve (AUC) 6] were administered. Results: A total of 138 patients with median age of 34 years, treated from September 2003 to December 2011, were selected. There were 5 relapses [5-year relapse-free rate (RFR) 96.8 % (95 % confidence interval 91.6–98.8)]: 3 relapses at retroperitoneal lymph nodes, 1 relapse at the adrenal gland, and 1 isolated brain metastasis. Four patients with relapse were cured with salvage chemotherapy. All patients with relapse had tumor diameter ≥4 cm and/or age ≤34 years. Patients with at least 1 of the above risk factors (n = 111) had a significantly higher relapse rate compared with a similar population (n = 64) treated with 2 cycles of adjuvant EP: 5-year RFR was 95 % (SE 2 %) versus 100 % (SE 0 %), (p = 0.067). Conclusions: Age and tumor diameter were associated with relapse in stage I seminoma treated with adjuvant carboplatin. Although adjuvant carboplatin in patients with age ≤34 and/or tumor diameter ≥4 cm is associated with higher relapse rates than EP, the prognosis of these patients is excellent, and therefore, the use of less toxic treatment is justified. © 2015, Springer-Verlag Berlin Heidelberg.

Purpose: Following the establishment of adjuvant carboplatin in stage I testicular seminoma as a standard, we adopted this treatment for all stage I seminoma patients. We report our 8-year experience and compare these results with our previous adjuvant etoposide/cisplatin (EP) strategy. Patients and methods: Patients with stage I seminoma, treated with adjuvant carboplatin and with a minimum follow-up of 1 year, were included. Two cycles of carboplatin [area under the curve (AUC) 6] were administered. Results: A total of 138 patients with median age of 34 years, treated from September 2003 to December 2011, were selected. There were 5 relapses [5-year relapse-free rate (RFR) 96.8 % (95 % confidence interval 91.6–98.8)]: 3 relapses at retroperitoneal lymph nodes, 1 relapse at the adrenal gland, and 1 isolated brain metastasis. Four patients with relapse were cured with salvage chemotherapy. All patients with relapse had tumor diameter ≥4 cm and/or age ≤34 years. Patients with at least 1 of the above risk factors (n = 111) had a significantly higher relapse rate compared with a similar population (n = 64) treated with 2 cycles of adjuvant EP: 5-year RFR was 95 % (SE 2 %) versus 100 % (SE 0 %), (p = 0.067). Conclusions: Age and tumor diameter were associated with relapse in stage I seminoma treated with adjuvant carboplatin. Although adjuvant carboplatin in patients with age ≤34 and/or tumor diameter ≥4 cm is associated with higher relapse rates than EP, the prognosis of these patients is excellent, and therefore, the use of less toxic treatment is justified. © 2015, Springer-Verlag Berlin Heidelberg.

Stroke is a leading cause of morbidity and mortality worldwide, and characterization of vulnerable carotid plaque remains the spearhead of scientific research. Plaque destabilization, the key factor that induces the series of events leading to the clinical symptoms of carotid artery disease, is a consequence of complex mechanical, structural and biochemical processes. Novel imaging and molecular markers have been studied as predictors of disease outcome with promising results. The aim of this review is to present the current state of research on the association between ultrasound-derived echogenicity indices and blood parameters indicative of carotid plaque stability and activity. Bibliographic research revealed that there are limited available data. Among the biomarkers studied, those related to oxidative stress, lipoproteins and diabetes/insulin resistance are associated with echolucent plaques, whereas adipokines are associated with echogenic plaques. Biomarkers of inflammation and coagulation have not exhibited any conclusive relationship with plaque echogenicity, and it is not possible to come to any conclusion regarding calcification-, apoptosis- and neo-angiogenesis-related parameters because of the extremely limited bibliographic data.

The estimation of cardiovascular tissue motion from ultrasound images is a task of considerable importance but has remained difficult in clinical practice, mainly due to the limitations of ultrasound imaging and the complexity of tissue motion. This paper presents a survey of methodologies, along with physiologically relevant findings, regarding the estimation of motion of the myocardium and of central and peripheral arteries. Speckle tracking and modeling, and registration are the dominant methods used to calculate tissue displacements from sequences of images. Kinematic and mechanical indices are extracted from these displacements, which can provide valuable functional information about the cardiovascular system in normal and diseased conditions. An important application of motionbased strain indices involves the estimation of elastograms of the cardiovascular tissue. Motion analysis methods can be used to estimate a number of regional mechanical phenomena representing functional tissue properties, which are more sensitive to early changes due to ageing or disease. The importance of these methods lies in their potential to quantify in vivo tissue properties and to identify novel noninvasive personalized disease markers, toward early detection and optimal management of disease, along with increased patient safety. Their clinical usefulness remains to be demonstrated in larg trials.

Purpose: Recent studies have demonstrated that hypertension (HTN) is associated with non- alcoholic fatty liver disease (NAFLD) in treated hypertensive patients. The aim of this study was to investigate the association between newly diagnosed essential HTN and NAFLD in untreated hypertensive patients. Patients and methods: A consecutive series of 240 subjects (143 hypertensives and 97 normotensives), aged 30-80 years, without diabetes mellitus were enrolled in the study. Subjects with 24-hour systolic blood pressure (SBP) values ≥130 mmHg and/or diastolic BP values ≥80 mmHg were defined as hypertensives. NAFLD was defined as the presence of liver hyperechogenicity on ultrasound. Results: Body mass index (P=0.002) and essential HTN (P=0.016) were independently associated with NAFLD in the multivariate logistic regression model. Furthermore, the multivariate analysis revealed that morning SBP (P=0.044) was independently associated with NAFLD. Conclusion: Untreated, newly diagnosed essential HTN is independently associated with NAFLD. Ambulatory BP monitoring could be used for the diagnosis of essential HTN in patients with NAFLD. © 2016 Michopoulos et al.

Purpose: This analysis of the FIRST trial in patients with newly diagnosed multiple myeloma (MM) ineligible for stem-cell transplantation examined updated outcomes and impact of patient age. Patients and Methods: Patients with untreated symptomatic MM were randomly assigned at a one-to-one-to-one ratio to lenalidomide plus low-dose dexamethasone until disease progression (Rd continuous), Rd for 72 weeks (18 cycles; Rd18), or melphalan, prednisone, and thalidomide (MPT; 72 weeks), stratified by age (≤ 75 v > 75 years), disease stage (International Staging System stage I/II v III), and country. The primary end point was progression-free survival. Rd continuous and MPT were primary comparators. Results: Between August 21, 2008, and March 7, 2011, 1,623 patients were enrolled (Rd continuous, n = 535; Rd18, n = 541; MPT, n = 547), including 567 (35%) age older than 75 years. Higher rates of advanced-stage disease and renal impairment were observed in patients older than 75 versus 75 years of age or younger. Rd continuous reduced the risk of progression or death compared with MPT by 31% (hazard ratio [HR], 0.69; 95% CI, 0.59 to 0.80; P <.001) overall, 36% (HR, 0.64; 95% CI, 0.53 to 0.77; P <.001) in patients age 75 years or younger, and 20% (HR, 0.80; 95% CI, 0.62 to 1.03; P =.084) in those age older than 75 years. Median overall survival was longer with Rd continuous than with MPT, including a 14-month difference in patients age older than 75 years. Progression-free survival with Rd18 was similar to that with MPT, and overall survival with Rd18 was marginally inferior to that with Rd continuous. Rates of grade 3 to 4 treatment-emergent adverse events were similar for Rd continuous-treated patients age 75 years or older and those age older than 75 years; however, older patients had more frequent lenalidomide dose reductions. Conclusion: Results support Rd continuous treatment as a new standard of care for stem-cell transplantation-ineligible patients with newly diagnosed MM of all ages. © 2016 by American Society of Clinical Oncology.

Purpose: This analysis of the FIRST trial in patients with newly diagnosed multiple myeloma (MM) ineligible for stem-cell transplantation examined updated outcomes and impact of patient age. Patients and Methods: Patients with untreated symptomatic MM were randomly assigned at a one-to-one-to-one ratio to lenalidomide plus low-dose dexamethasone until disease progression (Rd continuous), Rd for 72 weeks (18 cycles; Rd18), or melphalan, prednisone, and thalidomide (MPT; 72 weeks), stratified by age (≤ 75 v > 75 years), disease stage (International Staging System stage I/II v III), and country. The primary end point was progression-free survival. Rd continuous and MPT were primary comparators. Results: Between August 21, 2008, and March 7, 2011, 1,623 patients were enrolled (Rd continuous, n = 535; Rd18, n = 541; MPT, n = 547), including 567 (35%) age older than 75 years. Higher rates of advanced-stage disease and renal impairment were observed in patients older than 75 versus 75 years of age or younger. Rd continuous reduced the risk of progression or death compared with MPT by 31% (hazard ratio [HR], 0.69; 95% CI, 0.59 to 0.80; P <.001) overall, 36% (HR, 0.64; 95% CI, 0.53 to 0.77; P <.001) in patients age 75 years or younger, and 20% (HR, 0.80; 95% CI, 0.62 to 1.03; P =.084) in those age older than 75 years. Median overall survival was longer with Rd continuous than with MPT, including a 14-month difference in patients age older than 75 years. Progression-free survival with Rd18 was similar to that with MPT, and overall survival with Rd18 was marginally inferior to that with Rd continuous. Rates of grade 3 to 4 treatment-emergent adverse events were similar for Rd continuous-treated patients age 75 years or older and those age older than 75 years; however, older patients had more frequent lenalidomide dose reductions. Conclusion: Results support Rd continuous treatment as a new standard of care for stem-cell transplantation-ineligible patients with newly diagnosed MM of all ages. © 2016 by American Society of Clinical Oncology.

Although UV-induced TiO2 photocatalysis involves the generation of several reactive oxygen species (ROS), the formation of hydroxyl radicals is generally associated with the degradation of persistent organic contaminants in water. In this study, a variety of radical scavengers were employed to discriminate the roles of different ROS during visible light-activated (VLA) photocatalysis using nitrogen and fluorine doped TiO2 (NF-TiO2) in the degradation of the hepatotoxin, microcystin-LR (MC-LR) in water. The addition of hydroxyl radical scavengers, methanol and tert-butyl alcohol to the reaction mixture resulted in negligible inhibition of NF-TiO2 photocatalytic degradation of MC-LR at pH 3.0 and only partial inhibition at pH 5.7 under visible light. While hydroxyl radicals ([rad]OH) generally play the primary role in UV-TiO2 photocatalysis, the minimal influence of MeOH and t-BuOH on the degradation process under these experimental conditions indicates that [rad]OH are not crucial in VLA NF-TiO2 photocatalysis. However, strong inhibition was observed in VLA NF-TiO2 photocatalytic degradation of MC-LR in the presence of superoxide dismutase, benzoquinone and catalase at pH 3.0 and 5.7 indicating that O2[rad]− and H2O2 play critical roles in the degradation process. Similar degradation rates were observed in the presence of deuterium oxide, which enhances singlet oxygen mediated processes further suggesting singlet oxygen is not a key species in the degradation of MC-LR. Formic acid and cupric nitrate were added to probe the roles of the valence band holes and conduction band electrons, respectively. Under UV–vis light irradiation, almost complete inhibition of MC-LR removal is observed with NF-TiO2 in the presence of [rad]OH scavengers at pH 5.7. These results demonstrate that the solution pH plays a major role in the formation and reactivity of ROS during VLA NF-TiO2 photocatalysis. The adsorption strength of scavengers and MC-LR onto NF-TiO2 as well as the speciation of ROS as a function of pH needs to be carefully considered since they also play a major role in the efficiency of the process. These results indicate that the reduction of molecular oxygen by photo-generated electrons rather than hydroxyl radicals produced by oxidative reactions of photo-generated holes is the key factor in the VLA NF-TiO2 photocatalytic degradation of MC-LR. © 2016 Elsevier B.V.

Background Advanced urothelial cancer (AUCa) is associated with poor long-term survival. Two major concerns are related to nonexposure to cisplatin-based chemotherapy and poor outcome after relapse. Our purpose was to record patterns of practice in AUCa in Greece, focusing on first-line treatment and management of relapsed disease. Methods Patients with AUCa treated from 2011 to 2013 were included in the analysis. Fitness for cisplatin was assessed by recently established criteria. Results Of 327 patients treated with first-line chemotherapy, 179 (55%) did not receive cisplatin. Criteria for unfitness for cisplatin were: Eastern Cooperative Oncology Group (ECOG) performance status (PS) ≥ 2, 21%; creatinine clearance ≤ 60 mL/min, 55%; hearing impairment, 8%; neuropathy, 1%; and cardiac failure, 5%. Forty-six patients (27%) did not fulfill any criterion for unfitness for cisplatin. The main reasons for these deviations were comorbidities (28%) and advanced age (32%). Seventy-four (68%) of 109 patients who experienced a relapse received second-line chemotherapy. The most frequent reason for not offering second-line chemotherapy was poor PS or limited life expectancy (66%). Conclusion In line with international data, approximately 50% of Greek patients with AUCa do not receive cisplatin-based chemotherapy, although 27% of them were suitable for such treatment. In addition, about one third of patients with relapse did not receive second-line chemotherapy because of poor PS or short life expectancy. Enforcing criteria for fitness for cisplatin and earlier diagnosis of relapse represent 2 targets for improvement in current treatment practice for AUCa. © 2016 Elsevier Inc.

Background Advanced urothelial cancer (AUCa) is associated with poor long-term survival. Two major concerns are related to nonexposure to cisplatin-based chemotherapy and poor outcome after relapse. Our purpose was to record patterns of practice in AUCa in Greece, focusing on first-line treatment and management of relapsed disease. Methods Patients with AUCa treated from 2011 to 2013 were included in the analysis. Fitness for cisplatin was assessed by recently established criteria. Results Of 327 patients treated with first-line chemotherapy, 179 (55%) did not receive cisplatin. Criteria for unfitness for cisplatin were: Eastern Cooperative Oncology Group (ECOG) performance status (PS) ≥ 2, 21%; creatinine clearance ≤ 60 mL/min, 55%; hearing impairment, 8%; neuropathy, 1%; and cardiac failure, 5%. Forty-six patients (27%) did not fulfill any criterion for unfitness for cisplatin. The main reasons for these deviations were comorbidities (28%) and advanced age (32%). Seventy-four (68%) of 109 patients who experienced a relapse received second-line chemotherapy. The most frequent reason for not offering second-line chemotherapy was poor PS or limited life expectancy (66%). Conclusion In line with international data, approximately 50% of Greek patients with AUCa do not receive cisplatin-based chemotherapy, although 27% of them were suitable for such treatment. In addition, about one third of patients with relapse did not receive second-line chemotherapy because of poor PS or short life expectancy. Enforcing criteria for fitness for cisplatin and earlier diagnosis of relapse represent 2 targets for improvement in current treatment practice for AUCa. © 2016 Elsevier Inc.

Background The present global, open-label, single-arm, multicenter, phase IIb study was designed to determine the efficacy and tolerability of oral vorinostat combined with standard doses of bortezomib in patients with multiple myeloma considered refractory to novel myeloma agents. Patients and Methods Eligible patients were age ≥ 18 years, had received ≥ 2 previous regimens, had disease refractory to ≥ 1 previous bortezomib-containing regimen, and had received ≥ 1 dose of an immunomodulatory drug (thalidomide or lenalidomide)-based regimen. The patients received 21-day cycles of bortezomib (1.3 mg/m2 intravenously on days 1, 4, 8, and 11) plus oral vorinostat (400 mg/d on days 1-14). Oral dexamethasone, 20 mg, on the day of and the day after each dose of bortezomib could be added for patients with progressive disease after 2 cycles or no change after 4 cycles. The primary endpoint was the objective response rate. Results The objective response rate was 11.3% (95% confidence interval, 6.6%-17.7%), and the median duration of response was 211 days (range, 64-550 days). The median overall survival duration was 11.2 months (95% confidence interval, 8.5-14.4 months), with a 2-year survival rate of 32%. The frequently reported adverse events were thrombocytopenia (69.7%), nausea (57.0%), diarrhea (53.5%), anemia (52.1%), and fatigue (48.6%); the overall safety profile was consistent with that of bortezomib and vorinostat. Conclusion The combination of vorinostat and bortezomib is active in patients with multiple myeloma refractory to novel treatment modalities and offers a new therapeutic option for this difficult-to-treat patient population (ClinicalTrials.gov identifier, NCT00773838). © 2016 Elsevier Inc.

Background The present global, open-label, single-arm, multicenter, phase IIb study was designed to determine the efficacy and tolerability of oral vorinostat combined with standard doses of bortezomib in patients with multiple myeloma considered refractory to novel myeloma agents. Patients and Methods Eligible patients were age ≥ 18 years, had received ≥ 2 previous regimens, had disease refractory to ≥ 1 previous bortezomib-containing regimen, and had received ≥ 1 dose of an immunomodulatory drug (thalidomide or lenalidomide)-based regimen. The patients received 21-day cycles of bortezomib (1.3 mg/m2 intravenously on days 1, 4, 8, and 11) plus oral vorinostat (400 mg/d on days 1-14). Oral dexamethasone, 20 mg, on the day of and the day after each dose of bortezomib could be added for patients with progressive disease after 2 cycles or no change after 4 cycles. The primary endpoint was the objective response rate. Results The objective response rate was 11.3% (95% confidence interval, 6.6%-17.7%), and the median duration of response was 211 days (range, 64-550 days). The median overall survival duration was 11.2 months (95% confidence interval, 8.5-14.4 months), with a 2-year survival rate of 32%. The frequently reported adverse events were thrombocytopenia (69.7%), nausea (57.0%), diarrhea (53.5%), anemia (52.1%), and fatigue (48.6%); the overall safety profile was consistent with that of bortezomib and vorinostat. Conclusion The combination of vorinostat and bortezomib is active in patients with multiple myeloma refractory to novel treatment modalities and offers a new therapeutic option for this difficult-to-treat patient population (ClinicalTrials.gov identifier, NCT00773838). © 2016 Elsevier Inc.

The Aegean-west Anatolian orocline formed due to mainly post-15 Ma opposite rotations of its western and eastern limbs, which contributed to the opening of the Aegean back-arc basin. Stretching lineations in exhumed metamorphic complexes in this back-arc basin mimic the regional vertical axis rotation patterns and suggests that the oppositely rotating domains are bounded by the ‘Mid-Cycladic Lineament’, the tectonic nature of which is enigmatic. Some authors have proposed this lineament to be extensional fault accommodating orogen-parallel extension, while others considered it a transform fault. The island of Paros hosts the only exposure of the Mid-Cycladic Lineament: the northwest of the island contains E-trending and the southeast contains N trending stretching lineations. Here, we show new paleomagnetic results from isotropic, ~16 Ma granitoids that intruded both domains. These demonstrate that the trend difference resulted from post-16 Ma ~90° clockwise and 10° counterclockwise rotation of the northwest and southeast blocks, respectively. We show that a greenschist facies, semi-ductile to brittle, low-angle, southeast dipping normal fault zone, here identified as the Elitas Shear Zone that we interpret as the Mid-Cycladic Lineament accommodates this rotation difference on Paros. We conclude a two-stage exhumation history for Paros that is consistent with regional Aegean reconstructions. Between ~23 and 16 Ma, the metamorphic rocks of Paros exhumed from amphibolite-facies to greenschist facies conditions along a top-to-the-north detachment. The Elitas shear zone then started to exhume the northwestern clockwise rotating domain from below the southeastern, counterclockwise rotating domain since 16 Ma. We demonstrate at the only location at which a structure coinciding with Mid-Cycladic Lineament is exposed, it is extensional in nature, consistent with geometrical predictions that Aegean oroclinal bending must have been accommodated by combined orogen-normal and orogen-parallel extension.

On 2014 April 23, the Swift satellite responded to a hard X-ray transient detected by its Burst Alert Telescope, which turned out to be a stellar flare from a nearby, young M dwarf binary DG CVn. We utilize observations at X-ray, UV, optical, and radio wavelengths to infer the properties of two large flares. The X-ray spectrum of the primary outburst can be described over the 0.3-100 keV bandpass by either a single very high-temperature plasma or a nonthermal thick-target bremsstrahlung model, and we rule out the nonthermal model based on energetic grounds. The temperatures were the highest seen spectroscopically in a stellar flare, at T X of 290 MK. The first event was followed by a comparably energetic event almost a day later. We constrain the photospheric area involved in each of the two flares to be >1020 cm2, and find evidence from flux ratios in the second event of contributions to the white light flare emission in addition to the usual hot, T ∼ 104 K blackbody emission seen in the impulsive phase of flares. The radiated energy in X-rays and white light reveal these events to be the two most energetic X-ray flares observed from an M dwarf, with X-ray radiated energies in the 0.3-10 keV bandpass of 4 × 1035 and 9 × 1035 erg, and optical flare energies at E V of 2.8 × 1034 and 5.2 × 1034 erg, respectively. The results presented here should be integrated into updated modeling of the astrophysical impact of large stellar flares on close-in exoplanetary atmospheres.

On April 23, 2014, the Swift satellite responded to a hard X-ray transient detected by its Burst Alert Telescope, which turned out to be a stellar flare from a nearby, young M dwarf binary DG~CVn. Observations at X-ray, UV and optical wavelengths of the main impulsive flare and subsequent smaller events reveal a complex pattern of flare events extending over about three weeks. We find that the X-ray spectrum of the primary outburst can be adequately described by either a single very high temperature plasma or a nonthermal thick-target bremmstrahlung model. By evaluating accompanying data of this event and analysis of a second brightening, we argue that the thermal interpretation is more likely on energetic grounds. The primary outburst lasted a few hours and produced the highest temperature thermal plasmas ever seen spectroscopically over the 0.3-100 keV range in a stellar flare, at TX of 300 MK. The X-ray luminosity of the main flare exceeded the bolometric luminosity of the brighter component (LX >1.6Lbol) for ~360 seconds. The first event was followed by a comparably energetic event almost a day later, whose coverage at X-ray and optical wavelengths enables inferences about it and the first event. In particular we find evidence for stellar radius-sized coronal loops filled with dense (ne>1012 cm-3) coronal plasma. The radiated energy in X-rays and white light reveal these first two events to be some of the most energetic X-ray and white light flares from an M dwarf. These structures require large coronal magnetic field strengths (a few kG for the first event, hundreds of Gauss for the second) to confine the plasma, and we thus predict an extremely high photospheric magnetic field strength of several kiloGauss.

The processing of all available XMM-Newton data in the LMC region, and those of the VLP survey in particular, was done with the data reduction pipeline developed in our research group over several years. Various non-X-ray data were used to supplement the XMM-Newton observations. They allow us to assess e.g. the relation between the population of SNRs and large scale structure of the LMC, or to evaluate doubtful candidates in the sample compilation. We compiled a sample of 59 definite SNRs, cleaned of misclassified objects and doubtful candidates. (2 data files).

Waldenström's macroglobulinemia (WM) is a rare, low-grade malignancy with no established standard of care. Rituximab regimens are most commonly used, supported by their efficacy in hematologic malignancies, including WM. A growing number of investigational regimens for WM have been evaluated in phase II clinical trials, including single-agent and combination strategies that include newer-generation monoclonal antibodies (ofatumumab and alemtuzumab), proteasome inhibitors (bortezomib and carfilzomib), immunomodulatory agents (thalidomide and lenalidomide), phosphoinositide 3-kinase/protein kinase B (Akt)/mammalian target of rapamycin pathway inhibitors (everolimus and perifosene), a Bruton's tyrosine kinase inhibitor (ibrutinib), and a histone deacetylase inhibitor (panobinostat). Other novel agents are in early-stage development for WM. International treatment guidelines for WM suggest suitable regimens in the newly diagnosed and relapsed/refractory settings, in accordance with patient age, disease presentation, and efficacy and safety profiles of particular drugs. These factors must be considered when choosing appropriate therapy for individual patients with WM, to maximize response and prolong survival, while minimizing the risk of adverse events. This review article provides a clinical perspective of the modern management of patients with WM, in the context of available trial data for novel regimens and recently updated treatment guidelines. © The Author 2015.

Waldenström's macroglobulinemia (WM) is a rare, low-grade malignancy with no established standard of care. Rituximab regimens are most commonly used, supported by their efficacy in hematologic malignancies, including WM. A growing number of investigational regimens for WM have been evaluated in phase II clinical trials, including single-agent and combination strategies that include newer-generation monoclonal antibodies (ofatumumab and alemtuzumab), proteasome inhibitors (bortezomib and carfilzomib), immunomodulatory agents (thalidomide and lenalidomide), phosphoinositide 3-kinase/protein kinase B (Akt)/mammalian target of rapamycin pathway inhibitors (everolimus and perifosene), a Bruton's tyrosine kinase inhibitor (ibrutinib), and a histone deacetylase inhibitor (panobinostat). Other novel agents are in early-stage development for WM. International treatment guidelines for WM suggest suitable regimens in the newly diagnosed and relapsed/refractory settings, in accordance with patient age, disease presentation, and efficacy and safety profiles of particular drugs. These factors must be considered when choosing appropriate therapy for individual patients with WM, to maximize response and prolong survival, while minimizing the risk of adverse events. This review article provides a clinical perspective of the modern management of patients with WM, in the context of available trial data for novel regimens and recently updated treatment guidelines. © The Author 2015.

{Several epidemiological studies have shown an association between particulate air pollution and adverse health effects. The consensus among the scientific community is that suspended particulate matter is one of the most harmful pollutants, particularly the inhalable particulate matter with aerodynamic diameters less than 10 mu m (PM10) causing respiratory health effects and heart diseases. The effects of aerosols on human health are determined by both their size and their chemical composition. Average daily concentrations exceeding the EU daily threshold concentration appear, among other cases, during Sahara dust episodes, a natural phenomenon that degrades the air quality in the urban area of Volos. The city of Volos is a coastal city of medium size in the eastern seaboard of Central Greece. The main objective of this work is the study of the temporal evolution and the assessment of weekend effect in particulate matter concentration levels in the centre of the city of Volos. PM10 data obtained by a fully automated station that was established by the Hellenic Ministry of Environment and Energy, for a 5-year period (2010-2014) are analyzed in order to study the day-of-week variations during the cold and warm period of the year. As these variations are mostly expected to be due to the human working cycle, a strong weekly cycle would be indicative of the dominance of anthropogenic particles.}

© 2016 Wiley Periodicals, Inc. Depression and anxiety, the so-called common mental disorders (CMDs), are highly prevalent and disabling, yet remain largely untreated. This treatment gap is particularly true in low- and middle-income settings, where there is significant scarcity of resources (including human resources) and treatment accessibility is complicated by stigma surrounding mental illness. To address these challenges, the MANAS trial, one of the largest to date randomized, controlled trials, aimed to test the effectiveness of a stepped care intervention led by lay health counselors in primary care settings in Goa, India. Six- and 12-month follow-up outcomes suggest that MANAS was a safe, feasible, effective, and cost-effective intervention for CMDs in that context. This article demonstrates the use of culturally adapted IPT as an intervention to treat CMDs in a 54-year-old Indian primary care patient struggling with depression and heart-related problems after his wife's death. A case formulation is presented based on core IPT principles, followed by detailed delineation of treatment from beginning through termination.

We call monomer a B-DNA base pair and study, analytically and numerically, electron or hole oscillations in monomers, dimers and trimers. We employ two tight binding (TB) approaches: (I) at the base-pair level, using the on-site energies of the base pairs and the hopping parameters between successive base pairs i.e. a wire model, and (II) at the single-base level, using the on-site energies of the bases and the hopping parameters between neighbouring bases, specifically between (a) two successive bases in the same strand, (b) complementary bases that define a base pair, and (c) diagonally located bases of successive base pairs, i.e. an extended ladder model since it also includes the diagonal hoppings (c). For monomers, with TB II, we predict periodic carrier oscillations with frequency –550 THz. For dimers, with TB I, we predict periodic carrier oscillations with –100 THz. For trimers made of identical monomers, with TB I, we predict periodic carrier oscillations with –33 THz. In other cases, either with TB I or TB II, the oscillations may be not strictly periodic, but Fourier analysis shows similar frequency content. For dimers and trimers, TB I and TB II are successfully compared giving complementary aspects of the oscillations.

We report the X-ray detections of three novae in observations of the M31 northern disk by XMM-Newton in January 2016. In continuation of earlier observations described in ATels #8227 and #8228, a further two 100-ks observations were carried out on 2016-01-01 (ObsID 0763120401) and 2016-01-21 (ObsID 0763120201).

We report on the first detection of X-ray dust-scattered rings from the Galactic low-mass X-ray binary V404 Cyg. The observation of the system with Swift/XRT on 2015 June 30 revealed the presence of five concentric ring-like structures centred at the position of V404 Cyg. Follow-up Swift/XRT observations allowed a time-dependent study of the X-ray rings. Assuming that these are the result of small-angle, single X-ray scattering by dust grains along the line of sight, we find that their angular size scales as θ ∝ √{t} in agreement with theoretical predictions. The dust grains are concentrated in five dust layers located at about 2.12, 2.05, 1.63, 1.50 and 1.18 kpc from the observer. These coincide roughly with locations of enhanced extinction as determined by infrared photometry. Assuming that the grain size distribution is described by a generalized Mathis-Rumpl-Nordsieck model, we find that the power-law index of the most distant cloud is q ∼ 4.4, while q ∼ 3.5-3.7 in all other clouds. We constrain at a 3σ level the maximum grain size of the intermediate dust layers in the range 0.16-0.20 μm and set a lower limit of ∼ 0.2 μm in the other clouds. Hints of an exponential cutoff at the angular intensity profile of the outermost X-ray ring suggest that the smallest grains have sizes 0.01 ≤ αmin ≲ 0.03 μm. Based on the relative ratios of dust column densities we find the highest dust concentration at ∼1.6 kpc. Our results indicate a gradient in the dust properties within 1 kpc from V404 Cyg.

XMMU J004855.5-734946 is a candidate BeXRB system in the Small Magellanic Cloud (SMC, Haberl & Sturm 2016, A & A, 586, 81). The system was detected in a recent 45 s Swift/XRT observation on 2016-06-24 as part of a routine Swift/XRT survey of the SMC (ATel #9197).

The Magellanic Clouds (MCs) offer an ideal laboratory for the study of the SNR population in star-forming galaxies, since they are relatively nearby and free of large absorption. Both the LMC and SMC have been targeted by large XMM-Newton surveys, which, combined with archival observations, provide the best dataset to systematically study the X-ray emission of their numerous SNRs (∼ 60 in the LMC, ∼ 20 in the SMC). In this talk, I will highlight the results from this homogeneous analysis, which allows for the first time meaningful comparisons of temperature, chemical composition, and luminosity of SNRs in the MCs. The SNRs can be used as probes of their host galaxies: We measured chemical abundances in the hot phase of the LMC, and constrained the ratio of core-collapse to type Ia SN rates. The X-ray luminosity function of SNRs in the MCs are compared to those in other Local Group galaxies with different metallicities and star formation properties. Finally, we present a new population of evolved type Ia SNRs that was discovered recently in the MCs via their iron-rich X-ray emission.

Αυτή η εργασία επικεντρώνετε στον κρίσιμο ρόλο του Αθλητισμού στην προώθηση της κοινωνικής ενσωμάτωσης: τη χρήση του αθλητισμού για την αντιμετώπιση κοινωνικών ζητημάτων που σχετίζονται με την εξάλειψη κοινωνικών διακρίσεων, τη διερεύνηση τεχνικών αντιμετώπισης συγκρούσεων και την κοινωνική ένταξη. Αρχικά, στην πρώτη ενότητα, εξετάζεται ο διεθνής διάλογος, πρόσφατα αποτελέσματα ερευνών, για κοινωνικά φαινόμενα όπως ο ρατσισμός και η ξενοφοβία. Παρατηρείτε ότι οι αντιλήψεις για τους μετανάστες και πρόσφυγες (και στη χώρα μας) προκαλούν ανησυχίες για εκείνους που ασχολούνται με την πολυπολιτισμικότητα, το σεβασμό για τα ανθρώπινα δικαιώματα, τη φυλετική και την έμφυλη πολυμορφία, την κοινωνική ισότητα και ισονομία, το νόημα του έθνους, της πατρίδας κ.ά.  Η διεθνής βιβλιογραφία δείχνει ότι όσο ισχυρότερο είναι το κοινωνικό κεφάλαιο των μεταναστών, τόσο περισσότερο διευκολύνεται η κοινωνική τους ένταξη. Τα τελευταία 25 χρόνια η Ελλάδα έχει μετατραπεί σε χώρα μαζικής υποδοχής μεταναστών. Ωστόσο, η αναγνώριση του γεγονότος ότι οι μετανάστες αποτελούν μόνιμη πραγματικότητα στη χώρα μας είναι πρόσφατη και ο δημόσιος διάλογος σχετικά με την κοινωνική και οικονομική τους ενσωμάτωση εξελίσσεται. Στη δεύτερη ενότητα διερευνάται  η χρήση του Αθλητισμού (και της φυσικής αγωγής) ως μέσου για την καλλιέργεια μιας κουλτούρας/παιδείας ειρήνης (peace education) ή ως εργαλείου για την επίλυση συγκρούσεων, ιδιαίτερα ενόψει των αυξανόμενων διαφωνιών και συγκρούσεων που σχετίζονται με τη διαχείριση της προσφυγικής κρίσης— που πλήττει κατά 60% τις γυναίκες και τα παιδιά— για την οποία κρίση η Ευρωπαϊκή Ένωση δεν έχει ολοκληρωμένη πολιτική διαχείρισης. Εντούτοις, αναδεικνύεται ότι ο Αθλητισμός μπορεί να συμβάλλει ουσιαστικά στην κοινωνική ενσωμάτωση των μεταναστών. Πρόσφατη έρευνα της Ευρωπαϊκής Επιτροπής (Σεπτ. 2016)—που συμπεριλαμβάνει 63 «καλές πρακτικές» (good practices)— τεκμηριώνει τη συμβολή του Αθλητισμού στην κοινωνική ενσωμάτωση τον μεταναστών και προσφύγων στην Ευρώπη. 

Ο τόμος περιλαμβάνει τις ακαδημαϊκές συμβολές επιστημόνων που συνεργάστηκαν ή/και μαθήτευσαν με τον Δημήτρη Ματθαίου. Αποτελείται από μια («επιλεκτική», όπως χαρακτηριστικά αναφέρεται) εισαγωγή στο έργο και τις ιδέες του και αποτελείται από πέντε κύριες ενότητες, οι οποίες αντιπροσωπεύουν επιστημονικά πεδία με τα οποία ασχολήθηκε ο τιμώμενος. Συγκεκριμένα αποτελείται από τις ενότητες «Στοχασμοί για την εκπαίδευση», «Ζητήματα εκπαιδευτικής πολιτικής», «Ανώτατη εκπαίδευση», «Διοίκηση της εκπαίδευσης» και «Συγκριτική σπουδή της εκπαίδευσης».Οι επιμελητές του τόμου είχαν την ευθύνη της πρόσκλησης των συγγραφέων, της κατανομής τους σε ενότητες και την επιμέλεια των κειμένων. Οι τρεις εκ των επιμελητών (Κ. Φασούλης, Ι. Ρουσσάκης, Α. Σαμαρά) ανέλαβαν την ευθύνη συγγραφής του εισαγωγικού κεφαλαίου.

Καμπερίδου, Ειρήνη (2016). 'Αφηγήσεις Δυτικών Περιηγητριών  του 18ου, 19ου και αρχές 20ου αιώνα: «Εάν κάθε Τούρκος πασάς είχε μία Ασπασία πόσο θα βελτιωνόταν το γένος των Μωαμεθανών…»   (Celine 1849)'.  Εισήγηση στην Ημερίδα: «Η Διάσταση του Φύλου στην κοινωνική πολιτική και κοινωνιολογία», Γ’ Πάνελ.  Κέντρο Πολιτισμού και Εκπαίδευσης «ΠΟΛΙΣ», Νέο Ηράκλειο,  9 Οκτ. 2016. Social Policy.gr. :  Κοινωνική Πολιτική – Κοινωνική Θεωρία. --http://socialpolicy.gr/2016/09/%CE%B7%CE%BC%CE%B5%CF%81%CE%AF%CE%B4%CE%B1-%CE%B7-%CE%B4%CE%B9%CE%AC%CF%83%CF%84%CE%B1%CF%83%CE%B7-%CF%84%CE%BF%CF%85-%CF%86%CF%8D%CE%BB%CE%BF%CF%85-%CF%83%CF%84%CE%B7%CE%BD-%CE%BA%CE%BF%CE%B9.html --https://www.facebook.com/events/1097230350345846/  

Τὸ μεσανατολικὸ γεωπολιτικὸ σύστημα, ἀναδιαρθροῦται μὲ ταχυτάτους ρυθμοὺς καὶ οἱ ἐσωτερικοὶ πυλῶνες ἰσχύος τῶν ἑκάστοτε ὑποσυστημάτων του διαμορφώνουν ἕνα πολύπλοκο δίκτυον ἀνακατανομῆς ἰσχύος ἐπηρεαζόμενομενο μὲ πρωτοφανεῖς τρόπους ἀπὸ τοὺς Πόλους Ἰσχύος τοῦ Ὑπερσυστήματος, ὅπως οἱ ΗΠΑ, ἡ Ρωσσία, ἡ Κίνα, καὶ συγκεκριμένα κράτη-μέλη τῆς Εὐρωπαϊκῆς Ἑνώσεως. Στὸ πλαίσιο αὐτὸ ἄκρως ἐνδιαφέρουσα εἶναι ἡ πλήρης ἀποτυχία τῆς ∆ημοκρατικῆς administration τῆς Οὐάσιγκτων, νὰ δημιουργήσει μίαν «ἰσλαμοδημοκρατικὴ» Τουρκία ἡ ὁποία, μὲ ἐργαλεῖον προβολῆς ἰσχύος τὴν Ὀργάνωση τῶν Ἀδελφῶν Μουσουλμάνων τῆς Αἰγύπτου, θὰ ἐλειτουργοῦσε ὡς ἰσλαμικοῦ τύπου «δημοκρατικὸ» πρότυπον διακυβερνήσεως γιὰ ὅλες τὶς ἰσλαμικοῦ πολιτισμικοῦ ὑποβάθρου χῶρες τῆς Εὐρυτέρας Μέσης Ἀνατολῆς, ἀποτελοῦσα καὶ γεωστρατηγικὸν ἀνάχωμα στὶς Μεσογειακὲς βλέψεις τῆς Ρωσσίας. Η παρούσα ομιλία αναφέρεται στη γεωπολιτικὴ ἀνάγνωση τοῦ γεωπολιτικού συστήματος τῆς ΝΑ Μεσογείου καὶ στον ἐρντογανικὸ ἀναθεωρητισμὸ.

Ἡ ἀνάγνωσις τοῦ Γεωπολιτικοῦ Συμπλόκου τοῦ Εὐρω-ἀμερικανικοῦ ∆ιπόλου μὲ Γεωπολιτικὸ Παράγοντα (geopolitical factor) ἐντασσόμενο στὸν σκληρὸ πυρῆνα τοῦ Πολιτισμικοῦ Πυλῶνος (cultural pilar), τὸν παράγοντα τῆς πολιτισμικῆς ταὐτότητος, προσφέρει τὴν εἰκόνα ἑνὸς δυναμικοῦ καὶ μεταλασσόμενου γεωπολιτικοῦ πεδίου (geopolitical field), τὸ ὁποῖον παρουσιάζει κοινὰ ἐθνικο-ταὐτοτικὰ πολιτισμικὰ στοιχεῖα καὶ στρέφεται οὐσιαστικῶς ἐναντίον μιᾶς διεθνοποιημένης τραπεζικῆς πραγματικότητος μὴ βασιζομένης σὲ πραγματικὴ παραγωγὴ ἀλλὰ σὲ ἰδιαίτερα ὑψηλοὺς δεῖκτες μοχλεύσεως καὶ στὴν δημιουργία ἑνὸς Οἰκονομικοῦ ΝΑΤΟ ὑπὸ τὴν ὀνομασίαν τῆς (Transatlantic Trade and Investment Partnership) ΤΤΙP μὲ εὐρωπαῖο χειριστὴ τὴν Γερμανικὴ κυβέρνηση. Το κείμενο, εστιάζει στον τέταρτο γεωπολιτικό πυλώνα ισχύος, αυτόν του πολιτισμού.

Το βιβλίο εξετάζει σε βάθος τη δυναμική και τη διεργασία των ομάδων και των οργανισμών, τον ρόλο τους στην αντιμετώπιση των εσωτερικών κρίσεων αλλά και των πιέσεων που προέρχονται από ένα ασταθές και διαρκώς αβέβαιο εξωτερικό περιβάλλον. Ο ρόλος της ηγεσίας, οι συγκρούσεις, η εσωστρέφεια και η παθογένεια, αλλά και θέματα που αφορούν στην εκπαίδευση, την έρευνα και την εποπτεία των ομάδων εξετάζονται σε συνάρτηση με τη δυνατότητα των πάσης φύσεως ομάδων να μετεξελιχθούν από κλειστά σε ανοικτά συστήματα.

«Έγραψα μόνη μου την Εφημερίδα μου από την πρώτη ως την όγδοην σελίδα. Φυσικά υπό διάφορα ψευδώνυμα. Δεν είχα ούτε μία συνεργάτιδα. Είχα φέρει ένα Ιταλικόν ασήμαντον περιοδικό, καθώς και το Γαλλικόν του Léon Richer των Γυναικείων Δικαιωμάτων. Από αυτό είχα μεταφράσει μίαν μελέτη δια μίαν δημοσιογράφον Αμερικανίδα. […] Είναι 6 Μαρτίου του 1887. Το φύλλον είναι έτοιμον.»  Αν και η ιδρύτρια της Εφημερίδος των Κυριών - λαμβάνοντας υπόψη της τον εθνικιστικό λόγο της εποχής της - είχε επισταμένως φροντίσει, μέσα από κείμενα και δημόσιες παρεμβάσεις, να τονίσει και να αποδείξει την «ελληνικότητα» και την εθνική αποστολή του αγώνα της υπέρ των δικαιωμάτων των γυναικών προτείνοντας μια εναλλακτική νομιμοποιητική αφήγηση καθαρή από όποιες επείσακτες συνδηλώσεις, η μαρτυρία της αυτή γραμμένη στα 1915 είναι δηλωτική του ρόλου που έπαιξαν τα δυτικά πρότυπα της γυναικείας αμφισβήτησης τόσο στη συγκρότηση μιας φεμινιστικής συνείδησης στην Ελλάδα όσο και στην οργάνωση της εγχώριας συλλογικής γυναικείας κίνησης. Την αμφίθυμη και εν πολλοίς "αποσιωπημένη" αυτή σχέση του ελληνικού και του δυτικού φεμινιστικού κινήματος κατά τις τελευταίες δεκαετίες του 19ου αιώνα φιλοδοξεί να αναδείξει η παρούσα ανακοίνωση. Με επίκεντρο τον διάλογο που αναπτύσσεται προνομιακά με τη γαλλική γυναικεία κίνηση - πιο οικεία λόγω και της έντονης επιρροής του γαλλικού πολιτισμού στον ελληνικό χώρο εκείνη την περίοδο -, επιχειρείται μια πρώτη καταγραφή των πρωτοβουλιών και ενεργειών της Καλλιρόης Παρρέν και των συνεργατριών της (συστηματική παρακολούθηση των ξένων γυναικείων επιτευγμάτων και κατακτήσεων, συνεπής παρουσία στις διεθνείς συναντήσεις, επαφές με τα μέλη παλαιών και νέων φεμινιστικών δικτύων) με στόχο την ένταξη τους σε μια ευρύτερη οργάνωση, μια παγκόσμια «γυναικεία αδελφότητα» στο πλαίσιο της οποίας όμως η ελληνική συμμετοχή, σε ρόλο διαμεσολάβησης μεταξύ Δύσης και Ανατολής, φεμινισμού και ελληνισμού, φιλοδοξεί να διατηρήσει την ιδιαιτερότητά της.

© Καμπερίδου, Ειρήνη (2016) ). Ελληνισμός, Υποδούλωση, Τρομοκρατία και Δουλεία: Αφηγήσεις Δυτικών Περιηγητριών (HELLENISM, SUBJUGATION, TERRORISM AND SLAVERY: Personal Accounts by Western Women Travelers). Εισήγηση στο συνέδριο «Αθλητισμός – Πολιτισμός» του Συνδέσμου Φιλίας Εθνών (Σ.Φ.Ε.) σε συνεργασία με τη Σχολή Επιστήμης Φυσικής Αγωγής & Αθλητισμού (Σ.Ε.Φ.Α.Α.) του Εθνικού και Καποδιστριακού Πανεπιστημίου Αθηνών (Ε.Κ.Π.Α). Δάφνη, Αθήνα, 28-29 Μαΐου 2016: υπό την Αιγίδα του Εθνικού και Καποδιστριακού Πανεπιστημίου Αθηνών (ΕΚΠΑ). Επίσης, βλ.Proceedings/ Πρακτικά:   Καμπερίδου, Ειρήνη. (2016). Ελληνισμός, Υποδούλωση, Τρομοκρατία και Δουλεία: Αφηγήσεις Δυτικών Περιηγητριών. Πρακτικά- Εισηγήσεις Συνεδρίου «Αθλητισμός-Πολιτισμός» του Σύνδεσμος Φιλίας Εθνών (Σ.Φ.Ε.) σε συνεργασία με τη Σχολή Επιστήμης Φυσικής Αγωγής & Αθλητισμού (Σ.Ε.Φ.Α.Α.) του Εθνικού και Καποδιστριακού Πανεπιστημίου Αθηνών (Ε.Κ.Π.Α). © Copyright - afan.gr - Enfold Theme by Kriesi. [Πρακτικά Συνεδρίου: http://www.afan.gr/afan/%CE%B5%CE%B9%CF%83%CE%B7%CE%B3%CE%AE%CF%83%CE%B5%CE%B9%CF%82-%CF%83%CF%85%CE%BD%CE%B5%CE%B4%CF%81%CE%AF%CE%BF%CF%85-%CE%B1%CE%B8%CE%BB%CE%B7%CF%84%CE%B9%CF%83%CE%BC%CF%8C%CF%82-%CF%80%CE%BF%CE%BB/    

When citing/ παραπομπή: ©  Καμπερίδου, Ειρήνη (2016). «Επιχειρώντας Αλλιώς» στην εποχή της κρίσης: Η γυναικεία αθλητική επιχειρηματικότητα, ανεκμετάλλευτη πηγή κοινωνικού κεφαλαίου. Εισήγηση στην ημερίδα "Γυναίκα και Αθλητισμός – Επιχειρώντας Αλλιώς" της Κυπριακής Ολυμπιακής Επιτροπής (ΚΟΕ), της Επιτροπής   "Γυναίκα και Αθλητισμός" της ΚΟΕ, υπό την αιγίδα του Υπουργείου Παιδείας και Πολιτισμού, 9 Μαρτίου 2016,  στο Ολυμπιακό Μέγαρο, αίθουσα Ευ Αγωνίζεσθαι, Λευκωσία. DOI: 10.13140/RG.2.1.5054.6322 .... [...]   Σήμερα θα προβούμε σε ένα προβληματισμό ο οποίος έχει να κάνει με τη σχέση του Αθλητισμού και το "Επιχειρείν". Δεν θα επικεντρωθούμε στη γυναικεία υποεκπροσώπηση στον επιχειρηματικό στίβο  γενικότερα,  αλλά στις ανώνυμες ηρωίδες του «αθλητικού επιχειρείν» οι οποίες σταδιακά αυξάνονται. Θα δούμε ότι η Ολυμπιακή επιχειρηματικότητα δεν αποτελεί ανδρικό φαινόμενο, επειδή ο αθλητισμός προάγει  δεξιότητες (και για τα δύο φύλα) που είναι σημαντικά για το «επιχειρείν»,  δηλαδή για την επιχειρηματικότητα και την επαγγελματική επιτυχία. Πρόσφατες έρευνες (ποιοτικές και ποσοτικές)  καθώς και συνεντεύξεις με πρώην αθλήτριες, τεκμηριώνουν ότι  ένας αθλητικός προσανατολισμός, και ειδικά ο ομαδικός αθλητισμός –ή ένα ιστορικό αθλητικής εμπειρίας— αποτελεί χρήσιμο εργαλείο, όσον αφορά στην επιχειρηματικότητα και ειδικά όσον αφορά στην καλλιέργεια και ανάπτυξη ηγετικών δεξιοτήτων, όπως ένα πειθαρχημένο εργασιακό ήθος … … Λέξεις κλειδιά-  Επιχειρηματικότητα (entrepreneur, entrepreneurship), φύλο (gender), αθλητισμός,  φυσική αγωγή, αρχηγία, εξουσία,  ολιστική προσέγγιση: κουλτούρα συνεργασίας,  ηγεσία (εμπνέω, συντονίζω, καθοδηγώ), η πρώτη γυναίκα Ολυμπιακή επιχειρηματίας (Olympic entrepreneur: Alice Milliat) ** http://balla.com.cy/2016/03/10/imerida-ginaikas/ http://24h.com.cy/2016/03/07/hmerida-me-thema-gynaika-kai-athlitismos-epihirontas-allios-dia/

Στο παρόν κείμενο εξετάζονται τρεις υποθέσεις: α) η υπόθεσις όπου η Ρωσία κατισχύει δια του Πατριαρχείου της επί του Ορθοδόξου Χριστιανικού κόσμου, γεγονός το οποίο συνεπάγεται τη θραύση του Rimland στον άξονα Βαλκανικής Χερσονήσου-Μεσογείου, β) η υπόθεσις όπου το δίπολο Λονδίνου-Ουάσινγκτον συνεχίζει δια του Οικουμενικού Πατριαρχίου τον έλεγχον της εξόδου της Μόσχας στη Μεσόγειο και γ) η υπόθεσις όπου η Μόσχα και η Ουάσινγκτον συγκλίνουν για την αντιμετώπιση της κινεζικής προβολής ισχύος στην Μεσόγειο και όχι μόνον.

Πώς η Αμερική επηρεάζει την ελληνική κουλτούρα; Με ποιους τρόπους η Ελλάδα αφομοιώνει, επεξεργάζεται και μετουσιώνει την αμερικανική πολιτισμική επιρροή; Το βιβλίο εξετάζει την πολιτισμική σχέση Ελλάδας και Αμερικής, συνδυάζοντας διαφορετικές επιστημονικές προσεγγίσεις και εστιάζοντας στις πολλαπλές διαδικασίες μέσω των οποίων οι δυο κουλτούρες αλληλοτροφοδοτούνται και συνδιαλέγονται. Η διεξοδική ανάλυση των τρόπων με τους οποίους η Ελλάδα συναλλάσσεται με την αμερικανική κουλτούρα αποκαλύπτει όχι μόνο την αδιαμφισβήτητη παρουσία της αμερικανικής πολιτισμικής επιρροής στη χώρα μας, αλλά και ότι αυτή εμπλουτίζει, αντί να υποσκάπτει και να περιορίζει, όπως πολλοί πιστεύουν, την πολιτισμική έκφραση των Ελλήνων. Στο βιβλίο περιέχονται κείμενα συγγραφέων και ειδικών από τον χώρο της ιστορίας, της λογοτεχνικής θεωρίας, της ιστορίας της τέχνης, της γλωσσολογίας, της φιλοσοφίας και των μέσων μαζικής επικοινωνίας

Τα επιτραπέζια παιχνίδια μπορούν να αποκτήσουν εκπαιδευτικό χαρακτήρα στο πλαίσιο των μαθημάτων του σχολείου, με σημαντικά μαθησιακά αποτελέσματα. Κατά βάση συνεργάζονται σε ομάδες μαθητές με διαφορετικό επίπεδο γνώσεων, διαφορετικά κίνητρα και ικανότητες, διαφορετικό πολιτισμικό κεφάλαιο και οικονομικοκοινωνικό υπόβαθρο, για να κατανοήσουν και να μάθουν μέσω της επικοινωνίας, που αναπτύσσεται στο πλαίσιο ενός παιχνιδιού. Στην έρευνα που παρουσιάζεται στο παρόν μελετάται η διαδικασία του παιχνιδιού στην τάξη, η λειτουργία των ομάδων, η επικοινωνία των μελών τους, καθώς και η επίτευξη των προσδοκώμενων αποτελεσμάτων του μαθήματος που διδάσκεται μέσω του παιχνιδιού. Έγινε προσαρμογή ενός επιτραπέζιου παιχνιδιού (φιδάκι) στο εκπαιδευτικό περιβάλλον της Θρησκευτικής Εκπαίδευσης (μάθημα Θρησκευτικών) στο Γυμνάσιο με σκοπό την κατανόηση και μάθηση (γνώσεις και δεξιότητες). Μελετήθηκε η εφαρμογή του σε τμήμα της Β ́, στο 1ο Γυμνάσιο Αχαρνών, τη σχολική χρονιά 2013-14 μέσω παρατήρησης, ημερολογίων, ερωτηματολογίων και κριτηρίων αξιολόγησης. Η ανάλυση των αποτελεσμάτων, αφήνει πολλά περιθώρια να συμπεράνει κανείς την υψηλή παιδαγωγική-μετασχηματιστική αξία του επιτραπέζιου παιχνιδιού στη διδασκαλία.

Στο άρθρο αυτό γίνεται πρώτα λόγος για τη Θρησκευτική Εκπαίδευση στον ευρωπαϊκό χώρο, με ταυτόχρονες αναφορές στις διεθνείς συμβάσεις και συστάσεις του Συμβουλίου της Ευρώπης. Παράλληλα καταγράφεται και το ελληνικό νομοθετικό πλαίσιο, που διέπει τα θέματα της παροχής ΘΕ, της ανάπτυξης της θρησκευτικής συνείδησης σε σχέση με τη θρησκευτική ελευθερία, καθώς και το επίκαιρο ζήτημα των απαλλαγών από το μάθημα. Καταγράφονται, ακόμα, τα επιχειρήματα που σχετίζονται με την υποχρεωτική ή μη παρουσία της ΘΕ στον δημόσιο χώρο και διερευνάται το θέμα της αναγκαιότητάς της από παιδαγωγικής, κοινωνικής και πολιτισμικής πλευράς. Γίνεται, τέλος, αναφορά στον ιδιαίτερο χαρακτήρα (επιστημονικό –παιδαγωγικό) που έχουν τα νέα Προγράμματα Σπουδών της ΘΕ (2011, 2014, 2015), τα οποία φαίνεται να αποτελούν πρόταση που μπορεί να οδηγήσει, με τις λιγότερες κατά το δυνατό αντιδράσεις ή ασυμφωνίες, σε ένα ασφαλές μέλλον για την υποχρεωτική ΘΕ στην Ελλάδα με παιδαγωγικούς όρους.

ISSN 2529-1580. Η παρούσα δημοσίευση αποτελεί την εισήγησή μας στο 2ο Πανελλήνιο Συνέδριο ΕΕΠΕΚ για την εκπαιδευτική καινοτομία στη Λάρισα και περιλαμβάνει την περιγραφή και αναδρομή στα τέσσερα σχολικά έτη της εκπόνησης προγραμμάτων σχολικών δραστηριοτήτων σε γυμνάσια της Θεσσαλονίκης σχετικά με τη διδασκαλία για τα σύγχρονα βιοηθικά ζητήματα σε μαθητές της Γ΄ Γυμνασίου με καινοτόμα διδασκαλία, όπως με μορφές της Τέχνης (θέατρο-εικαστικά-αφήγηση) και ενεργοποίηση ρόλων (συμμετοχή σε εικονικές επιτροπες βιοηθικής).

Κεφάλαιο 1.1. Για την επιστηµονική µέθοδο: ιστορική διαδροµή. Από τον επιστηµονικό θετικισµό στον µεταθετικισµό. 1.1.1. Λογικός Θετικισµός. Στις αρχές του 20ού αιώνα κάνει την εµφάνισή του στη Βιέννη, το ρεύµα του Λογικού Θετικισµού, που ταυτίζεται µε µια οµάδα φιλοσόφων και διανοητών που είναι γνωστή ως ο «Κύκλος της Βιέννης». Το 1929 ο κύκλος της Βιέννης δηµοσίευσε τη διακήρυξή του µε τίτλο «Η επιστηµονική αντίληψη του κόσµου» γνωστοποιώντας στο κοινό τις φιλοσοφικές απόψεις του. Οι λογικοί θετικιστές απορρίπτουν τη µεταφυσική και προσπαθούν να αναγάγουν όλες τις δηλώσεις και τις προτάσεις στην καθαρή λογική. Ιδρυτές του θεωρούνται οι Hahn, Frank και Neurath. Η προσθήκη των Carnap, Feigl, Schlick κ.ά. οδήγησε στη συγκρότηση του «Κύκλου της Βιέννης», που αποτέλεσε την οµάδα που ταυτίστηκε και προώθησε τον Λογικό Θετικισµό.

Καμιά μορφή της Καινής Διαθήκης, πλην βεβαίως του Ιησού και της Θεοτόκου, δεν υπήρξε τόσο ισχυρός πόλος έλξης για τους ποιητές όσο η μορφή της Μαγδαληνής. Και καμιάς άλλης μορφής της Καινής Διαθήκης η ιστορία δεν παραποιήθηκε τόσο όσο η δικής της. Μείζονες, ελάσσονες και ασήμαντοι ποιητές βρίσκουν στο πρόσωπο της Μαγδαληνής στοιχεία πρόσφορα για την έκφραση ορισμένων βασικών συναισθημάτων τους και, όταν δεν τα βρίσκουν, τα εφευρίσκουν.Η πλην ολίγων εξαιρέσεων απεικόνιση από τους Έλληνες ποιητές της Μαγδαληνής ως μεταμεληθείσας αμαρτωλής οφείλεται σε σημαντικό βαθμό στην επίδραση των δυτικών λογοτεχνικών απεικονίσεων της Μαγδαληνής. Αν, ωστόσο, λάβουμε υπόψη ότι ποιητές όπως ο Σικελιανός, ο Βάρναλης, ο Καζαντζάκης, ο Ρίτσος ή ο Καρούζος ήταν βαθείς γνώστες του ευαγγελικού λόγου και της ελληνικής θρησκευτικής παράδοσης, δεν μπορούμε να μη σκεφτούμε ότι ο αριθμός των νεοελληνικών απεικονίσεων της Μαγδαληνής ως πρώην αμαρτωλής είναι υπερβολικά μεγάλος· και ότι το πλήθος αυτών των απεικονίσεων θα πρέπει να απορρέει και από το γεγονός ότι το θέμα της επανελθούσας στην οδό της αρετής γυναίκας είναι ποιητικά ελκυστικότερο από το θέμα της γυναίκας που σπάστηκε τον χριστιανισμό, όσο και αν αυτή ευεργετήθηκε από τον Χριστό ή όσο μεγάλη και αν υπήρξε η αγάπη της για Εκείνον.

In June 1946 George Seferis, the eminent Greek poet who was goingto become the Nobel-laureate patriarch of Greek modernist poetry by1963, witnessed the re-excavation of the statues and vases until thenhidden in the vaults of the National Museum in Athens in order toprevent their damage, or looting, by the Germans during the occupation.As he observes the bronze statue of Zeus, a fifth-century BC work thatis still considered one of the masterpieces in the Museum’s collectionand of Greek art at large, the poet fantasizes the god’s lovemaking witha woman whom Seferis himself “would love”, as he unashamedly informsus in his diary from that day. In the paper, I use the concept ofhomosociality in order to explore the ways in which Seferis and manyof his contemporaries view classical antiquity and proceed to deploy itas a bio-political tool in order to claim a centralized role in Greekintellectual and political life. To this end, I re-visit Seferis’s two chief“archaeological” poems –The King of Asine and Engomi – in an effortto investigate the ways in which his sensory archaeologies manifestthemselves.

Στο παρόν παρουσιάζεται η έρευνα ενός προγράμματος σχολικής δραστηριότητας (πολιτιστικών θεμάτων) που βασίζεται στη δημιουργία μαθητικής ραδιοφωνικής ομάδας στο 1ο Γενικό Λύκειο Ηρακλείου Αττικής και στην εβδομαδιαία παραγωγή τρίωρης εκπομπής στον Δημοτικό Ραδιοφωνικό Σταθμό, Επικοινωνία 94 Fm, με τίτλο «Σχολικά Παράσιτα». Σκοπός της έρευνας είναι η αξιολόγηση των μαθησιακών αποτελεσμάτων του προγράμματος και η βιωσιμότητα αυτών με βάση τη θεωρία της αναστοχαστικότητας, της βιωματικής-επικοινωνιακής παιδαγωγικής και της μετασχηματιστικής εκπαίδευσης. Με στοιχεία έρευνας-δράσης οι εκπαιδευτικοί από την πρώτη σχολική χρονιά παρακολούθησαν και διαμορφωτικά αξιολόγησαν την ανάπτυξη του προγράμματος, στο οποίο συμμετείχαν περισσότεροι από 300 μαθητές (το πρόγραμμα συνεχίζεται μέχρι σήμερα). Στο παρόν παρουσιάζονται συνοπτικά τα αποτελέσματα και συμπεράσματα της έρευνας από το 2010 έως 2013, τα οποία υπογραμμίζουν την υψηλή παιδαγωγική αποτελεσματικότητα του προγράμματος σε επίπεδο ανάπτυξης δεξιοτήτων πρωτίστως και δευτερευόντως απόκτησης νέων γνώσεων καθώς και τη μακροπρόθεσμη διατήρηση της γνώσης, όπως αυτή θεωρήθηκε στο πλαίσιο του προγράμματος με όρους κονστρουκτιβιστικής προσέγγισης της μάθησης.

Συμμετοχή στο ΣΥΜΠΟΣΙΟ με τίτλο: «Σύγχρονη Γυναίκα και Άθληση: Συμμετοχή, Προκλήσεις, Προοπτικές» της Πανελλήνιας Ένωσης για την Προώθηση των Γυναικών στον Αθλητισμό και τα Σπορ (ΠΕΠΓΑΣ) της Σχολής Επιστημών Φυσικής Αγωγής και Αθλητισμού του Αριστοτελείου Πανεπιστημίου Θεσσαλονίκης (ΑΠΘ), 25/11/2016, στο ΚΕΔΕΑ/Α.Π.Θ. [Επισυνάπτεται βεβαίωση συμμετοχής] Προσκεκλημένη στο πραναφερόμενο συμπόσιο μετά την προφορική ανακοίνωσή:Καμπερίδου, Ειρήνη. (2016). ΦΥΛΟ ΚΑΙ ΗΓΕΤΙΚΕΣ ΔΕΞΙΟΗΤΕΣ: ΤΟ ΑΘΛΗΤΙΚΟ ΕΠΙΧΕΙΡΕΙΝ. Προφορική Ανακοίνωση στο 2ο Διεθνές Συνέδριο Αθλητικών Επιστημών, Θεσσαλονίκη 25-27 Νοεμβρίου 2016, Κέντρο Διάδοσης Ερευνητικών Αποτελεσμάτων (ΚΕΔΕΑ). Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ). Copy at http://www.tinyurl.com/gtggejd 

Ερευνητικά δεδομένα τεκμηριώνουν ότι οι γυναίκες βρίσκονται ένα βήμα μπροστά από τους άντρες αναφορικά με κάποιες δεξιότητες, αποκαλούμενες στο παρελθόν «γυναικείες αρετές» ή «θηλυκές δεξιότητες» τις οποίες υιοθετούν όλο και περισσότεροι άνδρες επιχειρηματίες και στελέχη επιχειρήσεων σήμερα. Έρευνες που αφορούν την παραγωγικότητα δείχνουν ότι εταιρείες που απασχολούν και προωθούν γυναίκες σε ηγετικούς ρόλους εμφανίζουν, κατά μέσο όρο, περισσότερα κέρδη και μεγαλύτερη βιωσιμότητα. Με βάση τα αποτελέσματα μιας σχετικής με το ζήτημα φύλο και επιχειρηματικότητα ποιοτικής έρευνας, η μελέτη αυτή στοχεύει να αναδείξει σημαντικούς συσχετισμούς μεταξύ αθλητικής εμπειρίας και πετυχημένης επιχειρηματικότητας. Ερευνητικά στοιχεία τεκμηριώνουν ότι ένα ιστορικό αθλητικής εμπειρίας, ειδικά η συμμετοχή σε ομαδικά αθλήματα, αποτελεί χρήσιμο εργαλείο όσον αφορά στην καλλιέργεια ηγετικών δεξιοτήτων και στην ανέλιξη επιχειρηματικών δράσεων. Σχετικές έρευνες και συνεντεύξεις που πραγματοποιήθηκαν με εν ενεργεία και πρώην αθλήτριες, πρωταθλήτριες και ολυμπιονίκες πιστοποιούν ότι ο αθλητισμός προάγει δεξιότητες που είναι σημαντικές για το επιχειρείν. Θεωρείται ότι η αθλητική επιχειρηματικότητα αποτελεί ανδρικό φαινόμενο. Ωστόσο, Ελληνίδες αθλήτριες, γυμνάστριες, επιχειρηματίες και ακτιβίστριες που έχουν διαπρέψει στο αθλητικό επιχειρείν, μετά από σειρά συνεντεύξεων, μας παρέχουν πολύτιμες συμβουλές (tips-μέθοδοι-εργαλεία ενδυνάμωσης δεξιοτήτων) για επαγγελματική επιτυχία.     [Proceedings page 68—Πρακτικά 2ου Διεθνούς Συνεδρίου Αθλητικών Επιστημών (ICSS 2016) http://icss2016.web.auth.gr/el/proceedings/icss2016 (σελίδα 68) ]  

Καμπερίδου, Ειρήνη (2017). Φύλο και Ηγετικές Δεξιότητες: Γεφυρώνοντας το Έμφυλο Χάσμα. LWB-Leading Women in Business, σελ. 98-99.  Κεφάλαιο: Αρθρογραφία Επιφανών Λειτουργών και της ICAP για τη Γυναικεία Επιχειρηματικότητα.  Εκδότης: ΙCAP GROUP Α.Ε. ISSN 2241-4126  [e-book: http://dir.icap.gr/mailimages/e-books/LWB/index.html]    Η διανομή της έκδοσης πραγματοποιήθηκε αρχικά με «ΤΑ ΝΕΑ του Σαββατοκύριακου» στην Αττική (πριν την Πρωτοχρονιά, 30/12/2016) και με τη «ΜΑΚΕΔΟΝΙΑ» (σε CD) στη Θεσσαλονίκη. Επιπρόσθετα, θα μοιραστεί στην επίσημη εκδήλωση “High Heels on High Hills” το 2017 και σε άλλες εκδηλώσεις που διοργανώνει ή συμμετάσχει η ICAP.  Τέλος, θα διανεμηθεί σε φορείς της γυναικείας επιχειρηματικότητας (σε Αττική και Βόρεια Ελλάδα), καθώς και σε 2.000 εταιρείες και ακαδημαϊκά ιδρύματα, ως χρηστικό εργαλείο επί των εργασιών τους............................................. Kamberidou, Irene (2016). Gender and Leadership Skills: Bridging the Gender Gap, pp. 98-99 in LWB-Leading Women in Business. Publisher:  ICAP GROUP A.E. ISSN 2241-4126  [e-book: http://dir.icap.gr/mailimages/e-books/LWB/index.html]  The book circulated, for the first time on Dec. 30, 2016 in Athens with the daily newspaper TA NEA, and as a CD in Thessaloniki with the daily MACEDONIA. It will also be distributed at the 2017 “High Heels on High Hills” and other events and conferences organized by the ICAP Group. To assist researchers, students and entrepreneurs it will also be sent to 2.000 companies and academic institutions throughout Greece.

Η εργασία αυτή στοχεύει να αναδείξει σημαντικούς συσχετισμούς μεταξύ αθλητικής εμπειρίας και πετυχημένης επιχειρηματικότητας. Ερευνητικά στοιχειά τεκμηριώνουν ότι ένα ιστορικό αθλητικής εμπειρίας, ειδικά η συμμετοχή σε ομαδικά αθλήματα, αποτελεί χρήσιμο εργαλείο όσον αφορά στην καλλιέργεια ηγετικών δεξιοτήτων και την ανέλιξη επιχειρηματικών δράσεων. Η διεθνής έρευνα – που συμπεριλαμβάνει συνεντεύξεις με πρώην αθλήτριες και ολυμπιονίκες—δείχνει ότι ο αθλητισμός προαγάγει δεξιότητες που είναι σημαντικές για το επιχειρείν.  Όσον αφορά στην Ελληνική πραγματικότητα, επτά Ελληνίδες αθλήτριες, γυμνάστριες και ακτιβίστριες που έχουν διαπρέψει στο αθλητικό επιχειρείν, μετά από σειρά συνεντεύξεων, επιβεβαιώνουν τη σχέση μεταξύ αθλητικής εμπειρίας και πετυχημένης επιχειρηματικότητάς και παρέχουν πολύτιμες συμβουλές για επαγγελματική επιτυχία. Λέξεις-κλειδιά: αθλητική ταυτότητα, επιχειρηματικότητα, γυναίκα, έμφυλο χάσμα, ηγεσία.

Ответный ход Путина: господин Путин, однако, хочет поставить мат НАТО, и если понадобится, он с готовностью принесет в жертву «сумасшедшего». Это является единственным ходом, доступным Путину: он требует, чтобы Турция максимально быстро вышла из НАТО! В противном случае Эрдоган станет разменной монетой! Дилемма: примет ли или нет господин Эрдоган требование Путина, в конце этой истории его ждет Большой Курдистан. Разница заключается лишь в том, что, если он примет предложение Путина, то обеспечит себе пожизненный отпуск на даче, где-то в Крыму или в Сочи, покинув Турцию навсегда. В противоположном случае, впрочем, его ждет вилла в Саудовской Аравии! Его место почти наверняка займут «запасные политики» вроде Абдуллы Гюля или Ахмета Давутоглу, причем Турция останется инструментом США в «Евразийских Балканах». В обоих случаях обе супердержавы выигрывают: а) 50% территории через создаваемый Большой Курдистан б) развертывание сил на ближний средний восток в) богатые ресурсы г) Сирия получает небольшую долю от выигрыша США, России и Израиля. Партия Путин-США, похоже, заканчивается вничью. Однако нет, поскольку господин Путин серьезно нарастил противостояние юго-восточному крылу НАТО и перераспределил мощности на Ближнем и Среднем Востоке, наращивая несущественное, до недавнего времени, присутствие его сил на этой территории, путем пожертвования «бешеной пешки» в Ближневосточной шахматной игре.

We present 110 times of minima of 23 eclipsing binaries.

BACKGROUND: 18-Fluoro-2-deoxy-D-glucose positron emission tomography combined with computed tomography ((18)F-FDG PET/CT) scan is useful for diagnosis of osteoarticular infections. Whether (18)F-FDG PET/CT scanning may be used for therapeutic monitoring is not clear. The objective of this study was to develop (18)F-FDG PET/CT scanning for monitoring therapeutic response to antimicrobials in experimental Staphylococcus aureus osteomyelitis. METHODS: A total of 22 rabbits were studied. In 20 animals, the right tibia was inoculated intraoperatively with S. aureus. Two control animals were inoculated with normal saline. A needle was placed in the tibia as a foreign body. Infection was allowed to develop for 21 days when (18)F-FDG PET/CT was performed, the needle was removed, and bone specimens were cultured to confirm infection. Antimicrobial therapy with daptomycin was initiated in all successfully infected animals for 1, 3, or 6 weeks. Following completion of treatment, a second (18)F-FDG PET/CT was performed, animals were euthanized, and infected tibias were harvested for quantitative cultures and histology. A positive scan was defined as (18)F-FDG signal activity greater in the infected tibia than that of the contralateral non-infected control tibia. Therapeutic response was measured by the change of (18)F-FDG signal activity in the infected tibia. RESULTS: All successfully infected animals (n = 14), with microbiologically and/or histologically confirmed osteomyelitis, had positive (18)F-FDG PET/CT scans, while the two control animals had negative scans despite the presence of the foreign body [mean maximum standardized uptake value (SUVmax) (±SD) values 2.96 (±0.80) vs. 1 (±1.10), respectively, P = 0.04]. In the 14 successfully infected animals, the mean SUVmax was significantly higher in the infected compared to the uninfected tibia (P < 0.0001). A SUVmax of 1.4, when used as a cutoff for infection, yielded a diagnostic accuracy of 93 %. At the end of treatment, successfully treated animals and saline controls had a negative (18)F-FDG PET/CT scan (n = 4), while animals with persistent infection despite treatment (n = 12) had a positive (18)F-FDG PET/CT scan (SUVmax 1.0-3.0) (p < 0.001). SUVmax values were significantly reduced after 42 days of treatment from 3.15 ± 0.5 (day 7) to 1.71 ± 0.37 (day 42) (p = 0.05). CONCLUSIONS: (18)F-FDG PET/CT scan is a sensitive and specific tool in therapeutic monitoring of experimental foreign-body osteomyelitis.

OBJECTIVE: Hypertensive patients with CKD present an increased risk for cardiovascular mortality. Among the proteins synthesized and released from adipose tissue, resistin is a cytokine whose physiologic role has been the subject of much research and controversy. We and others have demonstrated that serum resistin levels are higher in patients with CKD and correlate directly with inflammatory markers, including TNF-α and hsCRP. Since inflammation has been consistently linked to atherosclerosis, death, and cardiovascular (CV) events, our goal was to investigate the interaction between resistin levels and long term all-cause and CV mortality in elderly non-obese and non-diabetic with hypertension. DESIGN AND METHOD: We studied 80 patients (52 men/28 women) 70.9 ± 8.6 years of age with hypertension and CKD. Exclusion criteria was obesity and diabetes mellitus, active infection, acute illness, chronic inflammatory disease or cancer, and immunosuppresive, anti-inflammatory or anti-lipidemic drugs. Demographic data, clinical information and blood samples were collected prospectively. The patients were observed for 5 years. RESULTS: During the follow-up 28 of 80 (35%) patients died: 16 (57%) deaths due to CV events and 12 (43%) of other causes. Patients who died were older and had higher DBP, compared to survivors, but had no differences in BMI, smoking, SBP and HR. Deceased patients had higher WBC, hsCRP, BUN, creatinine, cystatin C, phosphate, magnesium and potassium levels and lower eGFR, Hct/Hg, T3, T4, total cholesterol, LDL-C, albumin and sodium levels compared to survivors. No significant differences in platelet count, TNF-α, fibrinogen, oxLDL, ADMA, HgA1C and HOMA-index were revealed between the groups. eceased patients had significantly higher resistin levels than survivors at baseline (p = 0.025), but adiponectin, visfatin and leptin did not differ between the two groups. Five variables, namely resistin, sodium, cholesterol, T3 and WBC remained significantly associated with survival and were used in the multivariate Cox regression analysis, which revealed that only resisitin, cholesterol and WBC maintained their discriminatory ability, as independent predictors of mortality both by forward and backward stepwise analysis. CONCLUSIONS: Elevated serum resistin was a significant independent biomarker of CV and all-cause mortality in elderly, non-diabetic CKD patients with hypertension.

A model that contains a massive BH binary was proposed to explain the double peaked quasi-periodical (roughly about 12 years) outbursts of the blazar OJ287.

Ovarian carcinoma (OC) is the most lethal gynecological malignancy. Despite the advances in the treatment of OC with combinatorial regimens, including surgery and platinum-based chemotherapy, patients generally exhibit poor prognosis due to high chemotherapy resistance. Herein, we tested the hypothesis that DNA damage response (DDR) pathways are involved in resistance of OC patients to platinum chemotherapy. Selected DDR signals were evaluated in two human ovarian carcinoma cell lines, one sensitive (A2780) and one resistant (A2780/C30) to platinum treatment as well as in peripheral blood mononuclear cells (PBMCs) from OC patients, sensitive (n = 7) or resistant (n = 4) to subsequent chemotherapy. PBMCs from healthy volunteers (n = 9) were studied in parallel. DNA damage was evaluated by immunofluorescence ãH2AX staining and comet assay. Higher levels of intrinsic DNA damage were found in A2780 than in A2780/C30 cells. Moreover, the intrinsic DNA damage levels were significantly higher in OC patients relative to healthy volunteers, as well as in platinum-sensitive patients relative to platinum-resistant ones (all P <0.05). Following carboplatin treatment, A2780 cells showed lower DNA repair efficiency than A2780/ C30 cells. Also, following carboplatin treatment of PBMCs ex vivo , the DNA repair efficiency was significantly higher in healthy volunteers than in platinum-resistant patients and lowest in platinum-sensitive ones (t1/2 for loss of ãH2AX foci: 2.7± 0.5h, 8.8±1.9h and 15.4±3.2h, respectively; using comet assay, t1/2 of platinum-induced damage repair: 4.8±1.4h, 12.9±1.9h and 21.4±2.6h, respectively; all P<0.03). Additionally, the carboplatin-induced apoptosis rate was higher in A2780 than in A2780/C30 cells. In PBMCs, apoptosis rates were inversely correlated with DNA repair efficiencies of these cells, being significantly higher in plati-num-sensitive than in platinum-resistant patients and lowest in healthy volunteers (all P< 0.05). We conclude that perturbations of DNA repair pathways as measured in PBMCs from OC patients correlate with the drug sensitivity of these cells and reflect the individualized response to platinum-based chemotherapy. © 2015 Stefanou et al.

We present the results of a spectroscopic, photometric and orbital period variation analysis of the detached eclipsing binary V482 Per. We derived the absolute parameters of the system (M1 = 1.51 M⊙, M2 = 1.29 M⊙, R1 = 2.39 R⊙, R2 = 1.45 R⊙, L1 = 10.15 L⊙, L2 = 3.01 L⊙) for the first time in literature, based on an analysis of our own photometric and spectroscopic observations. We confirm the nature of the variations observed in the system's orbital period, suggested to be periodic by earlier works. A light time effect due to a physically bound, star-sized companion (M3 = 2.14 M⊙) on a highly eccentric (e = 0.83) orbit, seems to be the most likely cause. We argue that the companion can not be a single star but another binary instead. We calculated the evolutionary states of the system's components, and we found that the primary is slightly evolving after the main sequence, while the less massive secondary lies well inside it.

In this chapter, we focus on recommender systems that are enhanced with social information in the form of trust statements between their users. The trust information may be processed in a number of ways, including the random walks in the social graph, where every step in the walk is chosen almost uniformly at random from the available choices. Although this strategy yields satisfactory results in terms of the novelty and the diversity of the produced recommendations, it exhibits poor accuracy because it does not fully exploit the similarity information among users and items. Our work tries to model user-to-user and user-to-item relation as a probability distribution using a novel approach based on Rejection Sampling in order to decide its next step (biased random walk). Some initial results on reference datasets indicate that a satisfying trade-off among accuracy, novelty, and diversity is achieved.

Higher body mass index and adiposopathy have been associated with increased risk of hematologic malignancies such as leukemia, multiple myeloma, myeloproliferative disorders, Hodgkin's and non-Hodgkin's lymphoma, and myelodysplastic syndromes. Adiponectin is a multimeric protein of the white adipose tissue presenting anti-inflammatory, insulin-sensitizing, anti-atherogenic, cardioprotective, and anti-neoplastic properties. Its anti-neoplastic actions are manifested via two mechanisms: (i) direct action on tumor cells by enhancing receptor-mediated signaling pathways and (ii) indirect action by regulating inflammatory responses, influencing cancer angiogenesis, and modulating insulin sensitivity at the target tissue site. In the bone marrow milieu, adiponectin and its main receptors are expressed by the majority of bone marrow stromal cell populations influencing hematopoietic stem cells function. Adiponectin may represent a molecular mediator relating adiposopathy with leukemogenesis and myelomagenesis. Several epidemiological studies conducted to date relate hypoadiponectinemia to the risk of myeloid-derived hematopoietic cancer and multiple myeloma. Adiponectin may be a promising biomarker with potential diagnostic and prognostic utility in determining the likelihood of myeloma and leukemia progression in certain cohorts of monoclonal gammopathy of undetermined significance patients and in myeloid hematologic malignancies, respectively. This review summarizes experimental and epidemiologic data regarding the role of adiponectin in hematologic malignancies in the context of adiposopathy. Enhancement of endogenous adiponectin, adiponectin replacement, or manipulation of adiponectin receptor sensitivity may be an attractive goal for prevention and an effective therapeutic strategy against hematopoietic cancer, specifically in overweight/obese individuals. Further studies are required to elucidate the role of the bone marrow microenvironment adiponectin in complex interactions involved in preleukemic and leukemic states.

In two short-term diary studies, conducted in an educational and a sport context, we investigated whether adolescents' domain-specific and situation-specific self-determined motivation, along with future time perspective, could explain intrapersonal variation of and interpersonal differences in psychological functioning. In both studies intrapersonal fluctuation of self-determined motivation related positively to desired outcomes, with perceived autonomy operating as a predictor of situation-specific self-determined motivation (Study 2). Moreover, in both Study 1 ( N = 57 high-school students) and Study 2 ( N = 63 athletes participating in a three-week basketball camp) we found interpersonal differences in domain-specific autonomous motivation and future time perspective to predict positively mean levels of most of the positive outcomes. These results underscore the key role of self-determined motivation and future time perspective in the prediction of psychological functioning and the importance of looking not only at the interpersonal differences but also at the underlying motivational dynamics operating at the within-person level. [ABSTRACT FROM AUTHOR]Copyright of Journal of Social & Clinical Psychology is the property of Guilford Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This meta-analysis aimed to examine the association between alcohol consumption and multiple myeloma (MM) risk. Eligible publications were sought in PubMed to 31 December 2013. Separate analyses were performed by study design, gender, alcoholic beverages and levels of consumption. Sixteen case-control studies (3921 cases and 19 594 controls) and 10 cohort studies (3167 incident cases in total cohort of 2 557 649 subjects) were eligible. Ever consumption of alcohol was associated with reduced MM risk (pooled relative risk [RR] = 0.88, 95% confidence interval [CI]: 0.79-0.99) and especially consumption of wine correlated with reduced MM risk (pooled RR = 0.77, 95% CI: 0.67-0.89 for ever drinkers). MM risk was not affected by beer or liquor intake. A protective association was observed among females (pooled RR = 0.79, 95% CI: 0.69-0.89 for ever drinkers), whereas the association among males seemed null. In conclusion, contrary to most solid tumors, alcohol intake may confer protection in terms of MM risk among females, with wine being particularly beneficial. © 2014 Informa UK, Ltd.

It is a great consensus in the scientific community that environmental factors, such as weather conditions and ambient air pollution, have vital impacts on respiratory diseases. Further, these factors imply the potential to have many significant impacts on aeroallergens, and therefore related diseases such as asthma and allergic rhinitis. The impacts are more pronounced in sensitive groups of population, such as children and elderly, living in urbanized areas. Over the last three decades, studies have shown changes in production, dispersion and allergen content of pollen and spores, which may be region- and species-specific. In addition, these changes may have been influenced by air pollutants interacting directly with pollen. It is not easy to evaluate the impact of climate change and air pollution on the prevalence of asthma in general and on the timing of asthma exacerbations. However, the global rise in asthma prevalence and severity suggests that air pollution and climate changes could be contributing. The objective of this review is to summarize the environmental impacts on pulmonary diseases in children based on recent literature over the world. © 2015, Frontiers in Bioscience. All rights reserved.

In contrast to the upfront setting in which the role of high-dose therapy with autologous hematopoietic cell transplantation (HCT) as consolidation of a first remission in patients with multiple myeloma (MM) is well established, the role of high-dose therapy with autologous or allogeneic HCT has not been extensively studied in MM patients relapsing after primary therapy. The International Myeloma Working Group together with the Blood and Marrow Transplant Clinical Trials Network, the American Society of Blood and Marrow Transplantation, and the European Society of Blood and Marrow Transplantation convened a meeting of MM experts to: (1) summarize current knowledge regarding the role of autologous or allogeneic HCT in MM patients progressing after primary therapy, (2) propose guidelines for the use of salvage HCT in MM, (3) identify knowledge gaps, (4) propose a research agenda, and (5) develop a collaborative initiative to move the research agenda forward. After reviewing the available data, the expert committee came to the following consensus statement for salvage autologous HCT: (1) In transplantation-eligible patients relapsing after primary therapy that did NOT include an autologous HCT, high-dose therapy with HCT as part of salvage therapy should be considered standard; (2) High-dose therapy and autologous HCT should be considered appropriate therapy for any patients relapsing after primary therapy that includes an autologous HCT with initial remission duration of more than 18 months; (3) High-dose therapy and autologous HCT can be used as a bridging strategy to allogeneic HCT; (4) The role of postsalvage HCT maintenance needs to be explored in the context of well-designed prospective trials that should include new agents, such as monoclonal antibodies, immune-modulating agents, and oral proteasome inhibitors; (5) Autologous HCT consolidation should be explored as a strategy to develop novel conditioning regimens or post-HCT strategies in patients with short (less than 18 months remissions) after primary therapy; and (6) Prospective randomized trials need to be performed to define the role of salvage autologous HCT in patients with MM relapsing after primary therapy comparing it to "best non-HCT" therapy. The expert committee also underscored the importance of collecting enough hematopoietic stem cells to perform 2 transplantations early in the course of the disease. Regarding allogeneic HCT, the expert committee agreed on the following consensus statements: (1) Allogeneic HCT should be considered appropriate therapy for any eligible patient with early relapse (less than 24 months) after primary therapy that included an autologous HCT and/or high-risk features (ie, cytogenetics, extramedullary disease, plasma cell leukemia, or high lactate dehydrogenase); (2) Allogeneic HCT should be performed in the context of a clinical trial if possible; (3) The role of postallogeneic HCT maintenance therapy needs to be explored in the context of well-designed prospective trials; and (4) Prospective randomized trials need to be performed to define the role salvage allogeneic HCT in patients with MM relapsing after primary therapy. © 2015 American Society for Blood and Marrow Transplantation.

Aretaeus of Cappadocia did not deal systematically with the study of anatomy, as it can be assumed from the thorough study of his remaining work, as well as the references to the topics and the fragments of his lost treatises. We could also extract useful information on anatomy through his analytical descriptions about the various diseases in his remaining work. A perfect example is the anatomy of the upper and inferior vena cava exposed in his work on acute diseases.

We present results from the application of Kopal's method for eclipsing binaries to the analysis of the transit light curve of exoplanet HD 209458, using very accurate photometric observations made with the Hubble Space Telescope. The fitting of the model parameters to the data was achieved by use of the Simulated Annealing algorithm. Furthermore, we utilized a transformation of the limb darkening coefficients that negates the need to specify limits for their values (uninformative sampling), yet still yield physically plausible results.