Publications by Year: 2009

We present the clinical and radiographic outcomes of the cementless low-contact-stress (LCS) rotating-platform total knee arthroplasty. Overall, 423 prostheses were implanted in 393 consecutive patients (30 patients had bilateral total knee replacement) for primary varus gonarthrosis (381 patients) and rheumatoid arthritis (12 patients). There were 81 men and 312 women with a mean age of 73 years (range, 58-85 years). Patella replacement was not performed in any case. Clinical and radiographic evaluation was performed using the Knee Society Score (KSS) and the Knee Society Assessment Form, respectively. The mean follow-up was 10 years (range, 5-15 years). Three patients were lost to follow-up. Survival of the prostheses was 98% at 10 years; three prostheses required revision for deep infection, bearing dislocation, and periprosthetic fracture. The mean KSS improved significantly, from 42 and 44 points preoperatively to 90 and 79 points, respectively, at the latest evaluation (P < 0.001); results were excellent in 278 cases, good in 106, fair in 27, and poor in nine. Radiolucent lines were observed in 80 cases; revision arthroplasty was not performed in any of these cases. Complications included deep infection in one patient, bearing dislocation in one, skin necrosis in four, and a supracondylar fracture in one. The cementless LCS rotating-platform total knee arthroplasty is associated with excellent mid- and long-term results for patients with osteoarthritis and rheumatoid arthritis of the knee.

A series of 2-oxoamides based on dipeptides and pseudodipeptides were synthesized and their activities towards two human intracellular phospholipases A2 (GIVA cPLA2 and GVIA iPLA2) and one human secretory phospholipase A2 (GV sPLA2) were evaluated. Derivatives containing a free carboxyl group are selective GIVA cPLA2 inhibitors. A derivative based on the ethyl ester of an ether pseudodipeptide is the first 2-oxoamide, which preferentially inhibits GVIA iPLA2. The effect of 2-oxoamides on the generation of arachidonic acid from RAW 264.7 macrophages was also studied and it was found that selective GIVA cPLA2 inhibitors preferentially inhibited cellular arachidonic acid release; one pseudodipeptide gave an IC50 value of 2 μM.

Ozellikle soğuk savas doneminde etkili olan Anglosakson jeostratejik yaklasım, cok onemli iki Anglosakson coğrafyacı ve jeopolitik uzmanı Sir Halford Mackinder (1861-1947) ve Nicholas Spykman (18931943) tarafından dile getirilmistir. Bu jeopolitik modellerden, Ege takım adalarını ve onun devamı Girit ile Kıbrıs’ ı iceren dikey coğrafi alanın, Rimland’ ın stratejik bolumunu olusturduğunu ve aynı zamanda bu alanın NATO’ nun Guneydoğu kanadı icin bir istikrarsızlık noktası olduğu ortaya cıkıyor. Bu alanın stratejik kontrol altında tutulması icin Anglosaksonların ilgisi, 20’nci yuzyıl boyunca devamlı ve buyuk olmus, Soğuk Savas doneminde ise doruğa varmıstır. 50li ve 60lı yıllar arasında kalan donem, Soğuk Savasın tırmandığı ve iki buyuk rakip arasındaki tehlikeli olayların arttığı bir donemdir. Bizim analizimize gore Anglosakson “Ozel İliskisi”, yani Londra – Vasington jeostratejik iliskisi her zaman Batı olarak anılan tarafı, nitelendirmistir.

The aim of this study was to examine differences in intrinsic motivation and perceived academic competence as well as in their association between 5th- and 6th-grade students with learning disabilities (LD) (n = 40) and their typically achieving peers. Participants were 980 Greek elementary students from the metropolitan area of Athens. As predicted, students with LD showed lower intrinsic motivation and perceived academic competence than students without LD almost across all subscales. Exceptions were noticed in intrinsic motivation concerning curiosity/interest and history subscales as well as perceptions of academic competence in the subjects of history and science. Support was found that among typically achieving students intrinsic motivation was positively and significantly related at a moderate level to perceived academic competence across all subscales, as opposed to students with LD, for whom few correlations were found.

The purpose of the present study was to investigate the acute effect of drop jumping on throwing performance. Eight men and 8 women, moderately trained subjects with basic shot put skills, performed 3 squat underhand front shot throws after a short standard warm-up. Three minutes later they performed 5 maximal consecutive drop jumps from 40 cm. Immediately after the drop jumps, they repeated the squat underhand front shot throws. On another day, their 6 repetition maximum (RM) muscular strength in leg press was assessed. Muscle biopsies were also obtained from vastus lateralis for the determination of fiber-type composition and fiber cross-sectional area. Throwing performance was significantly increased after drop jumping (8.25 +/- 1.1 m vs. 8.63 +/- 1.3 m, p < 0.01). The percentage of type II muscle fiber area was significantly related to the increase in throwing performance after drop jumping (r = 0.76, p < 0.01). The increase in throwing performance was significant in men (8.94 +/- 1 m vs. 9.60 +/- 0.9 m, p < 0.01) but not in women (7.56 +/- 1 m vs. 7.67 +/- 0.9 m, ns). Of note, the percentage of type II fiber area was higher in men than in women (M: 66.4 +/- 13%, F: 50.2 +/- 15%, p < 0.01). Leg press strength (6RM) was moderately related to the increase in throwing performance after drop jumping (r = 0.50, p < 0.05). These results suggest that drop jumping just before a throwing action induces an increase in performance in subjects with a high percentage of type II muscle fiber area and (to a lesser degree) in subjects with enhanced muscular strength.

OBJECTIVE: The aim of this study was to investigate the role of vasomotor and mood symptoms on insomnia in postmenopausal women. METHODS: One hundred sixty-three postmenopausal women, not receiving hormone therapy, attending a menopause clinic at the University of Athens, Greece, were included in this cross-sectional study. Climacteric symptoms were assessed by Greene's scale, whereas psychological morbidity was measured by Zung Self-Assessment Depression Scale, Symptom Checklist-90-R, and Athens Insomnia Scale. RESULTS: Vasomotor symptoms were significantly associated with insomnia (P = 0.001). When depressive symptomatology was added to the logistic regression analysis, the predictive ability of the model was significantly improved as defined by the increase in the log likelihood (P < 0.001) and the increase in the area under the receiver operating characteristic curve. CONCLUSIONS: Insomnia in postmenopausal women attending a menopause clinic is related both to the effects of vasomotor symptoms and depressive symptomatology. Mood symptoms seem to affect sleep independently of vasomotor symptoms, suggesting that depression should be carefully assessed and treated in postmenopausal women with insomnia. © 2009 The North American Menopause Society.

OBJECTIVE: The aim of this study was to investigate the role of vasomotor and mood symptoms on insomnia in postmenopausal women. METHODS: One hundred sixty-three postmenopausal women, not receiving hormone therapy, attending a menopause clinic at the University of Athens, Greece, were included in this cross-sectional study. Climacteric symptoms were assessed by Greene's scale, whereas psychological morbidity was measured by Zung Self-Assessment Depression Scale, Symptom Checklist-90-R, and Athens Insomnia Scale. RESULTS: Vasomotor symptoms were significantly associated with insomnia (P = 0.001). When depressive symptomatology was added to the logistic regression analysis, the predictive ability of the model was significantly improved as defined by the increase in the log likelihood (P < 0.001) and the increase in the area under the receiver operating characteristic curve. CONCLUSIONS: Insomnia in postmenopausal women attending a menopause clinic is related both to the effects of vasomotor symptoms and depressive symptomatology. Mood symptoms seem to affect sleep independently of vasomotor symptoms, suggesting that depression should be carefully assessed and treated in postmenopausal women with insomnia.

CONTEXT: Higher adherence to a Mediterranean-type diet is linked to lower risk for mortality and chronic diseases, but its association with cognitive decline is unclear. OBJECTIVE: To investigate the association of a Mediterranean diet with change in cognitive performance and risk for dementia in elderly French persons. DESIGN, SETTING, AND PARTICIPANTS: Prospective cohort study of 1410 adults (> or = 65 years) from Bordeaux, France, included in the Three-City cohort in 2001-2002 and reexamined at least once over 5 years. Adherence to a Mediterranean diet (scored as 0 to 9) was computed from a food frequency questionnaire and 24-hour recall. MAIN OUTCOME MEASURES: Cognitive performance was assessed on 4 neuropsychological tests: the Mini-Mental State Examination (MMSE), Isaacs Set Test (IST), Benton Visual Retention Test (BVRT), and Free and Cued Selective Reminding Test (FCSRT). Incident cases of dementia (n = 99) were validated by an independent expert committee of neurologists. RESULTS: Adjusting for age, sex, education, marital status, energy intake, physical activity, depressive symptomatology, taking 5 medications/d or more, apolipoprotein E genotype, cardiovascular risk factors, and stroke, higher Mediterranean diet score was associated with fewer MMSE errors (beta = -0.006; 95% confidence interval [CI], -0.01 to -0.0003; P = .04 for 1 point of the Mediterranean diet score). Performance on the IST, BVRT, or FCSRT over time was not significantly associated with Mediterranean diet adherence. Greater adherence as a categorical variable (score 6-9) was not significantly associated with fewer MMSE errors and better FCSRT scores in the entire cohort, but among individuals who remained free from dementia over 5 years, the association for the highest compared with the lowest group was significant (adjusted for all factors, for MMSE: beta = -0.03; 95% CI, -0.05 to -0.001; P = .04; for FCSRT: beta = 0.21; 95% CI, 0.008 to 0.41; P =.04). Mediterranean diet adherence was not associated with the risk for incident dementia (fully adjusted model: hazard ratio, 1.12; 95% CI, 0.60 to 2.10; P = .72), although power to detect a difference was limited. CONCLUSIONS: Higher adherence to a Mediterranean diet was associated with slower MMSE cognitive decline but not consistently with other cognitive tests. Higher adherence was not associated with risk for incident dementia.

Extant pharmacological options for motor conversion disorder include mainly antidepressants and benzodiazepines. We report on the case of a 42-year-old female patient with frequent daily episodes of almost complete paralysis for the last 6 months resistant to an escitalopram-lorazepam combination at adequate doses. By contrast, the adjunctive administration of low-dose amisulpride at 200 mg/d to the patient's regimen resulted in her substantial and durable improvement. We hypothesize that low-dose amisulpride, acting as a selective antagonist of D2 and D3 dopamine autoreceptors, might reverse the decreased activity of frontal and subcortical dopaminergic circuits presumably involved in motor control during hysterical paralysis.

The new Environmental Seismic Intensity scale (ESI 2007), introduced by INQUA, incorporates the advances and achievements of palaeoseismology and earthquake geology and evaluates earthquake size and epicentre solely from the earthquake environmental effects (EEE). This scale is tested and compared with traditional existing scales for the 1981 Alkyonides earthquake sequence in the Corinth Gulf (Ms=6.7, Ms=6.4, Ms=6.3), the 1993 Pyrgos event (Ms=5.5) and the 2006 Kythira event (Mw=6.7). These earthquakes were of different magnitudes, focal mechanisms and focal depths and produced well-documented environmental effects. The ESI 2007 intensity values and the isoseismal pattern for the 1993 Pyrgos and the 2006 Kythira events are similar to those resulting from the traditional scales, demonstrating that for moderate intensity levels (VII and VIII) the ESI 2007 and the traditional scales comply well. In contrast, the 1981 Alkyonides earthquake sequence shows that there is an inconsistency between the ESI 2007 and the traditional scales both in the epicentral area, where higher ESI 2007 intensity values have been assigned, and for the far-field effects. The ESI 2007 scale offers higher objectivity in the process of assessing macroseismic intensities, particularly in the epicentral area, than traditional intensity scales that are influenced by human parameters. The ESI 2007 scale follows the same criteria-environmental effects for all events and can compare not only events from different settings, but also contemporary and future earthquakes with historical events. A reappraisal of historical earthquakes so as to constrain the ESI 2007 scale may prove beneficial for seismic hazard assessment by reducing the uncertainty implied in the attenuation laws, which constitute one of the most important seismic hazard parameters.

1. Kamberidou, I. (2009). "The Anachronistic Gender-Sport Imbalance:  the Glass Escalator or, Beyond the Glass Escalator".  Proceedings (pp. 97-100, Abstract ID2332) of the 16th IAPESGW World Congress: Practice and Research in Physical Education and Sport in the spirit of Ubuntu, Stellenbosch, South Africa 16-19 July. Department of Biokinetics, Sport and Leisure Sciences, University of Pretoria, with patronage by ICSSPE. the_anachronistic_sport.gender_imbalance._south_africa.pdf world_congress_programme.pdf proceedings._congress.july_2009.pdf, page 97, Abstract ID 332.    -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

We've come a long way since the 1952 Helsinki Games, where women represented only 10 percent of the Olympic athletes. At the 2008 Olympics in Beijing women represented approximately 43 percent of the total athlete delegation, up from 41 percent in the Athens 2004 Olympics. However, the "glass escalator " (Kamberidou 2009; Williams 1992, 1995) is not yet gender inclusive since women are exceedingly under-represented in all sport governing bodies (SGBs), primarily in the executive bodies of national and international sport organizations and institutions, such as the IOC. Researchers argue that men ride up the " glass escalator " when they enter predominantly female professions, as opposed to women who confront the glass ceiling and the " sticky floor " (Kimmel 2004) when they enter predominantly male professions. Taking their gender privilege with them, men experience positive discrimination (the glass escalator) when they enter female dominated social spheres, in other words they are socialized, encouraged, supported and promoted up the ladder even faster than their female counterparts. The first part of this study examines to what extent gender personification, the structurally secured and enforced gender segregation system continues-extends beyond the competitive sport expression, defeating the advocated values of social equity. In exploring the interrelation of social theories, anachronistic biologistic approaches and gender-based ideologies that established gender stereotypes and gender segregation in competitive sports, this paper renegotiates sport identity and corporeality in ways that reflect the processes of change in the construction of new sport identities: e.g. gender fluidity, men's participation in women's sports, respect for diversity, normalizing bodies and identities, bionic athletes, 'naturality' versus artificiality, emerging technologies used to enhance performance in competitive sports. (Miah 2005, et al.) Current discussions on the gender subject, no longer focus exclusively on the biological gender (sex), as an analytical category, but on the social gender (Kimmel 2004, McNay 2000) which formulates, defines and redefines identity, according to evolving socio-cultural interpretations. In the new theoretical framework, gender identity and corporeality are being rediscovered and are under reconstruction, namely viewed as linguistic conceptions, socio-cultural manifestations, transformable meanings and evolving elements of change. Such an example is men's participation in rhythmic gymnastics (Tsopani et al. 2006, Kamberidou, Tsopani, Dallas, Patsantaras 2009), despite gender stereotypes that depict the sport as unacceptable for the image of masculinity, including the male body aesthetic. In light of the growing participation of men in the competitive sport of rhythmic gymnastics—on national and international levels— in Japan, Australia, Canada, the US, Russia, Greece and Italy,

Thirty New Zealand white rabbits underwent anterior cruciate ligament (ACL) reconstruction in their right knees; 15 animals underwent a double-bundle anatomic ACL reconstruction using the medial third of the patellar tendon and the semitendinosus tendon. Additionally, 15 animals underwent ACL reconstruction, using a single-bundle semitendinosus tendon autograft. The knees of both groups were evaluated with a device similar to the KT1000 arthrometer onto which a dial indicator was attached (Mitutoyo dial indicator 2050) in 30 degrees and 90 degrees of flexion, preoperatively, after ACL resection and 3 months postoperatively. Statistical analysis of the results revealed that for 90 degrees of knee flexion, the mean estimated anterior shift for the double-bundle technique was 1.92 mm lesser than that of the single-bundle technique (P = 0.006). For 30 degrees of knee flexion, the mean anterior shift was again lesser than that of the single-bundle technique by 0.66 mm, but this difference was not statistically significant. The described double-bundle ACL reconstruction technique resulted in a more stable knee as far as the anterior tibial shift was concerned as compared to a single-bundle ACL reconstruction. This animal model may be potentially useful in the future for the study of other parameters influencing the outcome of the double-bundle ACL reconstruction.

Angiogenesis represents an essential step of disease progression in several hematological malignancies. In Waldenström's macroglobulinemia (WM) the bone marrow microvessel density is increased in 30%-40% of patients but seems to have no impact on survival. Angiogenic cytokines, such as angiogenin, vascular endothelial growth factor, and basic fibroblast growth factor are increased in the serum of WM or IgM-MGUS patients, while the ratio of angiopoietin-1/ angiopoietin-2 is reduced in WM but not in IgM-monoclonal gammopathy of undetermined significance (MGUS). Angiogenin and angiopoietin-1/angiopoietin-2 ratio correlates with disease activity and clinical features of WM. Macrophage and mast-cell chemoattractants, such as macrophage inflammatory protein-1 alpha are also elevated in the serum of patients with WM, while both macrophages and mast cells that are increased in the WM microenvironment have angiogenic properties and participate in the angiogenesis process in several malignancies. This review summarizes all data available by November 2008 (end of literature search) for the role of angiogenesis in the biology of WM and its correlation with clinical and laboratory features of the disease.

Cardiac contractility is regulated through the activity of various key Ca(2+)-handling proteins. The sarco(endo)plasmic reticulum (SR) Ca(2+) transport ATPase (SERCA2a) and its inhibitor phospholamban (PLN) control the uptake of Ca(2+) by SR membranes during relaxation. Recently, the antiapoptotic HS-1-associated protein X-1 (HAX-1) was identified as a binding partner of PLN, and this interaction was postulated to regulate cell apoptosis. In the current study, we determined that HAX-1 can also bind to SERCA2. Deletion mapping analysis demonstrated that amino acid residues 575-594 of SERCA2's nucleotide binding domain are required for its interaction with the C-terminal domain of HAX-1, containing amino acids 203-245. In transiently cotransfected human embryonic kidney 293 cells, recombinant SERCA2 was specifically targeted to the ER, whereas HAX-1 selectively concentrated at mitochondria. On triple transfections with PLN, however, HAX-1 massively translocated to the ER membranes, where it codistributed with PLN and SERCA2. Overexpression of SERCA2 abrogated the protective effects of HAX-1 on cell survival, after hypoxia/reoxygenation or thapsigargin treatment. Importantly, HAX-1 overexpression was associated with down-regulation of SERCA2 expression levels, resulting in significant reduction of apparent ER Ca(2+) levels. These findings suggest that HAX-1 may promote cell survival through modulation of SERCA2 protein levels and thus ER Ca(2+) stores.

Growing evidence suggests the involvement of glutamate in mood disorders and in the response to antidepressants. However, there is no information regarding a hypothesized sex-dependent glutamatergic modulation following treatment in animal models of depression. We comparatively assayed in male and female Flinders and control Sprague-Dawley rats glutamate and aspartate tissue levels in the prefrontal cortex, hippocampus and nucleus accumbens following 14-day treatment with either 10mg/kg clomipramine or mirtazapine, intraperitoneally. Clomipramine increased cortical glutamate in both sexes and hippocampal glutamate only in female Flinders rodents. Mirtazapine had no effect on cortical glutamate content but increased hippocampal glutamate in both Flinders sexes. Neither mirtazapine nor clomipramine altered glutamate levels in the nucleus accumbens. There were no any significant differences in aspartate levels. However, in control male SD rats clomipramine and mirtazapine significantly decreased cortical aspartate levels. Our results indicate that two different types of established antidepressants induce a brain region-specific effect on glutamate content. This effect is also characterized by sex-dependent differences mainly in the hippocampus, highlighting a differentiated response of glutamate to distinct antidepressants.

Ovarian cancer is one of the leading causes of cancer-related death among women. Disease relapse occurs in a high number of cases and treatment currently involves the use of chemotherapy with the use of paclitaxel and platinum-based agents. Resistance to the disease occurs in more than 70% of the cases. The immune system is increasingly becoming a target for intense research in order to study the host's immune response against ovarian cancer. T cell populations, including NK T cells and Tregs, have been associated with disease outcome indicating their increasing clinical significance, having been associated with positive prognosis and as markers of disease progress, respectively. Cytokines may also be associated with positive prognosis and they can have a direct or indirect effect in mobilizing relevant T cells, thus eliciting an immune response. Harnessing the immune system capacity in order to induce anti-tumor response is a major challenge. This is achieved via the use of antibodies that can elicit an immune response or via the use of direct administration of cytotoxic T cell populations (e.g., CD8+). This review examines the recent developments in our understanding of the mechanisms of development of the immune response in ovarian cancer as well as its prognostic significance and the existing experience in clinical studies using factors associated with immune response, such as monoclonal antibodies, cytokines, vaccines and activated or expanded relevant autologous populations from peripheral blood. © 2009 Springer-Verlag.

Objective Autoimmune thyroiditis and overt or subclinical hypothyroidism have been associated with increased prevalence of cardiovascular disease (CVD). Design Cross-sectional investigation of the association between gene polymorphisms related to CVD with thyroid function and autoimmunity. Patients In total 84 healthy postmenopausal women aged 49-69 years. Measurements FT3, FT4, anti-TPO and anti-TG were assessed in the sera of participants. The following polymorphisms were assessed from peripheral lymphocyte DNA: Apolipoprotein E E2/E3/E4, paraoxonase 1 A/B, Glycoprotein IIIa leu33pro, MTHFR ala222val, ApoBarg3500gln, plasminogen activator inhibitor 1 4G/5G, cholesterol 7-α hydroxylase A204C and cholesterol ester transfer protein B1/B2. Results A statistically significant correlation was found between Apolipoprotein E and paraoxonase1 polymorphisms and serum thyroid hormones: carriers of the E2 or E4 allele of the ApoE gene had lower levels of FT4 (P = 0·0005) than women with the E3/E3 genotype. Carriers of the B allele of paraoxonase 1 gene had lower levels of FT3 compared to women with the wild-type genotype (P = 0·047). A statistically significant positive association (P = 0·049) was also observed between anti-TG antibodies and the presence of the E2 allele of the Apolipoprotein E gene. Conclusions Polymorphisms of apolipoprotein E and paraoxonase 1 are associated with different levels of thyroid hormone and anti-Tg antibody levels in the study population in this pilot study. The mechanism underlying this association remains to be elucidated. © 2009 Blackwell Publishing Ltd.

Alzheimer disease (AD) is the most common type of dementia and will become increasingly prevalent with the growing elderly population. Despite established clinical diagnostic tools, the workup for dementia among primary caregivers can be complicated and specialist referral may not be readily available. A host of AD diagnostic tests has been proposed to aid in diagnosis, including functional neuroimaging such as positron emission tomography (PET). We review the basis for FDG-PET and PiB-PET, as well as available operating statistics. From this we advise scenarios for use of PET in primary settings and referral centers, approach to its interpretation, and outline a clinical prediction model based on findings.

Background: The introduction of mAbs has changed the clinical approach to patients with lymphoma and leukemia. Objective: To summarize the most significant applications of mAb-based regimens in the treatment of hematological malignancies and explore their possible role in the future management of these patients. Results: Rituximab (anti-CD20) was the first mAb developed for the treatment of B-cell lymphomas. Several randomized studies have demonstrated its efficacy in lymphomas and low toxicity profile; rituximab also has significant activity in chronic lymphocytic leukemia (CLL). Alemtuzumab (anti-CD52) has shown efficacy in previously untreated or refractory CLL patients, while gemtuzumab ozogamicin (anti-CD33) appears to have significant activity in acute myeloid leukemias and myelodysplastic syndromes. Conclusions: In the next few years, investigations will be concentrated on the improvement of the older mAbs, and the development of new mAbs, targeting molecules important for malignant cell cycle and survival in an attempt to further improve patient survival. © 2009 Informa UK Ltd All rights reserved.

Introduction: The adoption of e-learning platforms can offer a number of benefits including greater learning flexibility in several arenas including healthcare. The present study aims to explore the perceptions of healthcare postgraduate students regarding the adaptability of e-learning and Web-based courses. Methods: The research was based on the four dimensions of the Technology Acceptance Model, i.e. Perceived usefulness, Perceived ease of use, Attitude towards use and Behavioural intention. A questionnaire covering these 4 dimensions was created, uploaded on a website and the 39 MSc students enrolled in the Healthcare Management and Health Informatics at the Faculty of Nursing, University of Athens, Greece, invited to complete it. Completed questionnaires were analysed using Partial Least Squares and other statistical techniques. Results: A total of 20 questionnaires were fully completed. Analysis of the results demonstrated that postgraduate students appreciate and perceive usefulness and ease of use as key factors towards using e-learning platforms and online courses. Conclusion: The study has a number of limitations including the small sample size. For that reason, we conducted a downsized modeling scenario in order to produce observations and compare results, in terms of validity. Nevertheless despite these limitations, the current study can be useful in helping to guide the development and implementation of e-learning initiatives. © The Journal on Information Technology in Healthcare 2009.

BACKGROUND: The evaluation of academic research performance is nowadays a priority issue. Bibliometric indicators such as the number of publications, total citation counts and h-index are an indispensable tool in this task but their inherent association with the size of the research output may result in rewarding high production when evaluating institutions of disparate sizes. The aim of this study is to propose an indicator that may facilitate the comparison of institutions of disparate sizes. METHODS: The Modified Impact Index (MII) was defined as the ratio of the observed h-index (h) of an institution over the h-index anticipated for that institution on average, given the number of publications (N) it produces i.e. MII = h/10alphaNbeta (alpha and beta denote the intercept and the slope, respectively, of the line describing the dependence of the h-index on the number of publications in log10 scale). MII values higher than 1 indicate that an institution performs better than the average, in terms of its h-index. Data on scientific papers published during 2002-2006 and within 36 medical fields for 219 Academic Medical Institutions from 16 European countries were used to estimate alpha and beta and to calculate the MII of their total and field-specific production. RESULTS: From our biomedical research data, the slope beta governing the dependence of h-index on the number of publications in biomedical research was found to be similar to that estimated in other disciplines ( approximately 0.4). The MII was positively associated with the average number of citations/publication (r = 0.653, p < 0.001), the h-index (r = 0.213, p = 0.002), the number of publications with > or = 100 citations (r = 0.211, p = 0.004) but not with the number of publications (r = -0.020, p = 0.765). It was the most highly associated indicator with the share of country-specific government budget appropriations or outlays for research and development as % of GDP in 2004 (r = 0.229) followed by the average number of citations/publication (r = 0.153) whereas the corresponding correlation coefficient for the h-index was close to 0 (r = 0.029). MII was calculated for first 10 top-ranked European universities in life sciences and biomedicine, as provided by Times Higher Education ranking system, and their total and field-specific performance was compared. CONCLUSION: The MII should complement the use of h-index when comparing the research output of institutions of disparate sizes. It has a conceptual interpretation and, with the data provided here, can be computed for the total research output as well as for field-specific publication sets of institutions in biomedicine.

The repair of melphalan-induced N-alkylpurine monoadducts and interstrand cross-links was examined in different repair backgrounds, focusing on four genes (β-actin, p53, N-ras, and δ-globin) with dissimilar transcription activities. Adducts were found to be substrates for both global genome repair (GGR) and transcription-coupled repair (TCR), with TCR being less efficient than GGR. In nucleotide excision repair-deficient cells, adducts accumulated to similar levels in all four genes. The repair efficiency in different gene loci varied in a qualitatively and quantitatively similar way in both GGR-deficient and TCR-deficient backgrounds and correlated with transcriptional activity and local chromatin condensation. No strand-specific repair was found in GGR +/TCR+ cells, implying that GGR dominated. Adducts were lost over two sharply demarcated phases: a rapid phase resulting in the removal within 1 hour of up to ∼80% of the adducts, and a subsequent phase with t1/2 ∼36 to 48 hours. Following pretreatment of cells with α-amanitin, the rate of transcription, the state of chromatin condensation, and the repair efficiencies (both TCR and GGR) of the transcribed β-actin, p53, and N-ras genes became similar to those of the nontranscribed δ-globin gene. In conclusion, a continuous, parallel variation of the state of transcription and local chromatin condensation, on one hand, and the rates of both GGR and TCR, on the other hand, have been shown. ©2009 American Association for Cancer Research.

Environmental tobacco smoke (ETS) is a significant risk factor for the presence and increased severity of asthma- and allergy-related symptoms in children. Smoking during pregnancy has detrimental effects on asthma-associated outcomes in childhood. Whether passive exposure of pregnant women to ETS may also lead to asthma in their offspring, is not known. The aim of this study was to investigate the association of passive exposure of pregnant women to ETS and asthma- and/or allergy-related symptoms in Preschool children. Cross-sectional data were collected with questionnaires from 2374 Preschool children, recruited from public and private nurseries and day-care centers. Parental smoking was significantly associated with wheezing symptoms in their children. Mother's active smoking during pregnancy significantly increased the risk for occurrence of asthma symptoms and/or medically diagnosed asthma in Preschool children in a dose-dependent manner. Passive exposure to ETS, mainly during the third trimester of pregnancy, was significantly associated with asthma- and allergy-related symptoms after adjusting for several confounders in a multivariate analysis (current wheeze: OR = 1.42, 95% CI = 1.06-1.91, pruritic rash ever: OR= 1.45, 95% CI = 1.01-2.08). Passive exposure of pregnant women to ETS during the third trimester is positively associated with asthma- and allergy-related symptoms in their Preschool age children. Public health policies should be oriented not only towards smoking cessation, but also reinforce elimination of ETS exposure of pregnant women.

Objectives: Based on the Achievement Goal perspective [Dweck, C. S., Leggett, E. L (1988). A social-cognitive approach to motivation and personality. Psychological Review, 95, 256-273; Nicholls, J.G. (1984). Achievement motivation: conceptions of ability, subjective experience, task choice, and performance. Psychological Review, 91, 328-346] and on Pekrun et al.'s [(2004). Beyond test anxiety: development and validation of the test emotions questionnaire (TEQ). Anxiety, Stress, and Coping, 17, 287-316] model of discrete class-related emotions, this study investigated the relation of achievement goals to discrete emotions in the Physical Education (PE) class. Design: Cross-sectional. Method: Participants were 319 Greek upper elementary school students who responded to a set of questionnaires assessing their achievement goal orientation, perceived competence, and the class-related emotions they experienced in the PE classes. Results: Hierarchical regression analyses showed that, after controlling for perceived competence and gender differences, task goals were positively related to positive activating emotions and negatively related to negative emotions. Ego goals exhibited a mixed picture as they were positively associated with pride and all the negative emotions. Furthermore, the relations between ego goals and emotions were qualified by an ego by task goal and by an ego by perceived competence interaction suggesting that ego goals were especially linked to emotional maladjustment when task goals were low and when competence perceptions were high rather than low. Conclusion: Unique associations between task and ego goals and specific emotions were found, rendering insightful the disentanglement of positive and negative emotions into its components. The pursuit of task goals might help to counteract the emotional burden associated with ego goal pursuit whereas feeling competent to outperform when one endorses ego goals might perhaps put extra pressure on the pupils and, hence, have negative implications for their emotional adjustment. (C) 2008 Elsevier Ltd. All rights reserved.

Iron oxide Ferromagnetic Nanoparticles (FNs) such as magnetite (Fe3O4) and maghemite (gamma-Fe2O3) are currently employed in biomedical applications owing to their relatively high biocompatibility. Recently, we have introduced a novel application of Fe3O4 FNs in the so-called Magnetically Assisted Haemodialysis (MAHD), a promising concept that can be employed for the treatment of End-Stage Renal Disease. The key characteristic of MAHD is the selective removal of toxins that cannot be removed by current low-and high-flux dialysers that are extendedly used during conventional Haemodialysis (HD). In addition, MAHD could enable the more efficient removal of all toxins when compared to conventional HD so that the duration of dialysis session could be decreased. This is an important benefit that could significantly improve the quality of life of patient. The present work focuses on the in vitro evaluation of the biocompatibility of both bare Fe3O4 FNs and Fe3O4-Bovine Serum Albumin Conjugates (Fe3O4-BSA Cs) with blood cells, namely Red Blood Cells (RBCs), White Blood Cells (WBCs) and Platelets (Plts). Their solubility in whole human blood medium is also carefully evaluated. Both issues are fundamental for the MAHD application since the latter is based on the intravenous injection of FN Cs into the bloodstream of the patient. Atomic force microscopy and optical microscopy were employed for the investigation of both surface characteristics and overall morphology of blood cells, respectively. Samples of donated blood, where bare Fe3O4 FNs or Fe3O4-BSA Cs were added, were maturated under mild incubation for durations up to 120 min. We investigated two representative temperatures, T=20 degrees C owing to easy experimental realization, and T=37 degrees C trying to simulate human body conditions. We did not observe noticeable interference of either bare Fe3O4 FNs or Fe3O4-BSA Cs with RBCs, WBCs and Plts. More importantly we did not observe any degradation of the surface of RBCs and WBCs that were maturated under the presence of bare FNs or Cs in concentrations that strongly exceed the ones used for the treatment of iron-deficiency anaemia. Incidents where either bare FNs or Cs were bound onto the surface of RBCs or internalised by WBCs were very rare. Our observations suggest high biocompatibility of both bare Fe3O4 FNs and Fe3O4-BSA Cs with blood cells, while the solubility depends on the BSA content of the Fe3O4-BSA Cs.

AIM: While clinical endpoints provide important information on the efficacy of treatment in controlled conditions, they often are not relevant to decision makers trying to gauge the potential economic impact or value of new treatments. Therefore, it is often necessary to translate changes in cognition, function or behavior into changes in cost or other measures, which can be problematic if not conducted in a transparent manner. The Dependence Scale (DS), which measures the level of assistance a patient requires due to AD-related deficits, may provide a useful measure of the impact of AD progression in a way that is relevant to patients, providers and payers, by linking clinical endpoints to estimates of cost effectiveness or value. The aim of this analysis was to test the association of the DS to clinical endpoints and AD-related costs. METHOD: The relationship between DS score and other endpoints was explored using the Predictors Study, a large, multi-center cohort of patients with probable AD followed annually for four years. Enrollment required a modified Mini-Mental State Examination (mMMS) score >or= 30, equivalent to a score of approximately >or= 16 on the MMSE. DS summated scores (range: 0- 15) were compared to measures of cognition (MMSE), function (Blessed Dementia Rating Scale, BDRS, 0-17), behavior, extrapyramidal symptoms (EPS), and psychotic symptoms (illusions, delusions or hallucinations). Also, estimates for total cost (sum of direct medical cost, direct non-medical cost, and cost of informal caregivers' time) were compared to DS scores. RESULTS: For the 172 patients in the analysis, mean baseline scores were: DS: 5.2 (SD: 2.0), MMSE: 23.0 (SD: 3.5), BDRS: 2.9 (SD: 1.3), EPS: 10.8%, behavior: 28.9% psychotic symptoms: 21.1%. After 4 years, mean scores were: DS: 8.9 (SD: 2.9), MMSE: 17.2 (SD: 4.7), BDRS: 5.2 (SD: 1.4), EPS: 37.5%, behavior: 60.0%, psychotic symptoms: 46.7%. At baseline, DS scores were significantly correlated with MMSE (r=-0.299, p < 0.01), BDRS (r=0.610, p < 0.01), behavior (r=.2633, p=0.0005), EPS (r=0.1910, p=0.0137) and psychotic symptoms (r=0.253, p < 0.01); and at 4-year follow-up, DS scores were significantly correlated with MMSE (r=-0.3705, p=0.017), BDRS (r=0.6982, p < 0.001). Correlations between DS and behavior (-0.0085, p=0.96), EPS (r=0.3824, p=0.0794), psychotic symptoms (r=0.130, ns) were not statistically significant at follow-up. DS scores were also significantly correlated with total costs at baseline (r=0.2615, p=0.0003) and follow-up (r=0.3359, p=0.0318). DISCUSSION: AD is associated with deficits in cognition, function and behavior, thus it is imperative that these constructs are assessed in trials of AD treatment. However, assessing multiple endpoints can lead to confusion for decision makers if treatments do not impact all endpoints similarly, especially if the measures are not used typically in practice. One potential method for translating these deficits into a more meaningful outcome would be to identify a separate construct, one that takes a broader view of the overall impact of the disease. Patient dependence, as measured by the DS, would appear to be a reasonable choice - it is associated with the three clinical endpoints, as well as measures of cost (medical and informal), thereby providing a bridge between measures of clinical efficacy and value in a single, transparent measure.

This paper presents some of the most important known evidence up to this day, proving the defining British interference in the case of the Pogrom in Istanbul-Constantinople (Events of September 1955) and how these tragic events completely destroyed Hellenism of Constantinople are connected to the British colonial interests in Middle East. The theoretical methodological is based on the geopolitical analysis and, in particular, on the model proposed by the Anglo-Saxon Geographers - Geopoliticians Sir Halford Mackinder (1861-1947, School of Geography-London School of Economics) and especially in its elaborated form presented in 1944 by the American Professor of Yale, Nicolas Spykman (1893-1943, Yale Institute for International Studies, Yale University - USA). Therefore, this paper supports the theoretical hypothesis of the desire to preserve Rimland on the part of Britain and explains, based on the same theoretical model, the final approach of the USA towards the British stances. Naturally, the aforementioned model explains the role of Turkey. The presence of the secret paramilitary networks “Stay Behind”, known as Gladio also validates and fully supports the writer’s hypothesis.

Rhinoviruses (RVs) are responsible for the majority of acute asthma and chronic obstructive pulmonary disease (COPD) exacerbations. RVs infect the lower airways and induce the production of pro-inflammatory and remodelling-associated mediators. Budesonide (BUD) and formoterol (FORM) synergize in controlling asthma and COPD exacerbations; however, their effects on virus-induced inflammation and remodelling are less known.|We investigated whether BUD and FORM synergize in suppressing RV-induced inflammation and remodelling in the airways.|In vitro models of RV infection of BEAS-2B and primary normal human bronchial epithelial (NHBE) cells were used. We assessed the effects of individual and combined drugs administered post-infection, at a clinically relevant concentration range (10(-6)-10(-10) m), on the production of CCL5, CXCL10, CXCL8, IL-6 and the remodelling-associated VEGF and bFGF, using ELISA and RT-PCR.|BUD effectively suppressed RV-mediated induction of all mediators studied, in a concentration-dependent manner. FORM alone suppressed the production of CXCL8 and bFGF. The combination of BUD and FORM had concentration-dependent, additive or synergistic effects in the suppression of RV-induced CCL5, CXCL8 and CXCL10 in both cell types as well as VEGF in NHBE only. Combination treatment also resulted in an enhanced suppression of RV-induced IL-6, and CCL5 at the mRNA level as compared with BUD or FORM alone.|BUD and FORM suppress RV-induced chemokines and growth factors in bronchial epithelial cells in a concentration-dependent, synergistic or additive manner. These data further support the combined use of BUD and FORM in asthma and COPD and intensification of this therapy during exacerbations.

Purpose - The paper aims to define the mission, characteristics, objectives and evaluation processes concerning a specific training seminar entitled "Business administration for public sector executives". Furthermore, the research intends to underline the evaluation criteria, set by trainees and training officers as necessary in order to maximize the seminar's overall impact on all those involved.Design/methodology/approach - The seminar was organized by the University of Athens, Greece, in order to contribute to the continuing education of public sector executives in the field of business administration. The educational methodology was based on adult education principles and the evaluation included the preparation, development, and delivery phases. The seminar's effectiveness was assessed based on predetermined criteria and parameters using methods such as questionnaires, comments, observation and team discussions. Finding - Through this process the seminar's strengths and weaknesses were revealed by making use of quantitative analysis methodological tools, such as statistics and econometric prototypes. The trainees' overall response to the seminar was "measured" and the results proved the high-calibre structure and content of the seminar sessions. The trainees stated that the seminar offered key essential knowledge and aided in skill development; furthermore, they expressed their willingness to attend further lifelong-learning seminars. Practical implications - The criteria set forth by trainees and training officers alike could pave the way for a new approach to lifelong learning/training seminar design, implementation, and evaluation in the short-term future. Originality/value - The paper highlights the assessment criteria that offer meaningful insight into the participants' perceived level of seminar-related satisfaction and can potentially be utilised for the design of future seminars. © Emerald Group Publishing Limited.

A new catalog of visual double systems containing eclipsing binaries as one component is presented. The main purpose of this catalog is to compile a complete list of all known multiples of this variety, both for current analysis and to highlight those in need of additional observations. All available photometric and astrometric data were analyzed, resulting in new orbits for eight systems and new times of minimum light for a number of the eclipsing binaries. Some of the systems in the catalog have acceptable solutions for their visual orbits, although in most cases their orbital periods are too long for simultaneous analysis. Also included, however, are a number of systems which currently lack an orbital solution but which may be suitable for simultaneous analysis in the future.

Inland sand dune activities that set an interesting example in terms of wind erosion and accummulation in the Aegean Region under the conditions of the Mediterranean climate, and that appear on lands where the annual rainfall is about 600 mm, exist on the Akselendi Plain, Manisa. Until today, some studies have been conducted on the Akselendi Plain, which has become famous worldwide for that matter. Besides, there is an ongoing Bilateral Project with GREECE, supported by TUBITAK, some results of which will be explained in this paper. Besides the erosive winds blowing on the Akselendi Plain, the existence of mostly coarse textured alluvial deposits, the first of which is the large bed of Kum Çayı, moreover, the misuse of agricultural and non-agricultural areas have caused wind erosion, and they also caused the sediments, moving from the bed of Kum Çayı by deflation, to give great damages along with the sand dune invasion in the south of the bed. This activity has especially increased in the last fifty years. The views that we reached on the subject of wind erosion on this area and the causes, evolution and effects of sand dunes will be reported in the paper. Moreover, information will be given on the problems and on the status and efficiency of the precautions that have been taken, besides on the precautions that will need to be taken in the short term and long term. Again, the continued sand plunder because of the incorrect applications, and the effects of that on the sand dune formation will be explained. Also, some interesting formations that we determined in the last studies we conducted and that can set an example in this scientific area will be submitted to the world of science.

We present the most likely optical counterparts of 113 X-ray sources detected in our Chandra survey of the central region of the Small Magellanic Cloud (SMC) based on the OGLE-II and Magellanic Clouds Photometric Survey catalogs. We estimate that the foreground contamination and chance coincidence probability are minimal for the bright optical counterparts (corresponding to OB type stars; 35 in total). We propose here for the first time 13 high-mass X-ray binaries, of which four are Be/X-ray binaries (Be-XRBs), and we confirm the previous classification of 18 Be-XRBs. We estimate that the new candidate Be-XRBs have an age of ~15-85 Myr, consistent with the age of Be stars. We also examine the "overabundance" of Be-XRBs in the SMC fields covered by Chandra, in comparison with the Galaxy. In luminosities down to ~1034 erg s-1, we find that SMC Be-XRBs are ~1.5 times more common when compared to the Milky Way even after taking into account the difference in the formation rates of OB stars. This residual excess can be attributed to the lower metallicity of the SMC. Finally, we find that the mixing of Be-XRBs with other than their natal stellar population is not an issue in our comparisons of Be-XRBs and stellar populations in the SMC. Instead, we find indication for variation of the SMC XRB populations on kiloparsec scales, related to local variations of the formation rate of OB stars and slight variation of their age, which results in different relative numbers of Be stars and therefore XRBs.

Muscular adaptation which occurs following eccentric exercise-induced muscle damage has been associated with changes in the mechanical properties of muscle manifested as a shift in the length-tension relationship towards longer muscle lengths. However, it is not clear whether this shift is a long term adaptation to eccentric exercise. The purpose of this study was to investigate functional adaptations to skeletal muscle damage in humans, tracking such responses several days into muscle recovery. Ten healthy young men performed an eccentric exercise protocol involving the quadriceps muscle and functional measurements were performed before and on days 1, 2, 5, 8, 12 and 16 post-exercise. Blood samples were also withdrawn before and at 6 h, and 2 days, 5 days and 16 days post-exercise. The exercise protocol resulted in muscle damage, indicated by changes in clinical markers including increased serum creatine kinase activity and muscle soreness compared to pre-exercise levels (p<0.05-0.001). An acute, but not sustained shift in the quadriceps isokinetic and isometric angle-torque curves towards longer muscle lengths was observed post-exercise (p<0.05). It was speculated that the functional adaptations following eccentric exercise might be affected by the short resting and functional length of the quadriceps muscle, relative to its optimum. More studies are needed to confirm the hypothesis that a sustained shift in the muscle's length-tension relationship, as an adaptation after lengthening contraction-induced damage, is muscle specific.

Muscular adaptation which occurs following eccentric exercise-induced muscle damage has been associated with changes in the mechanical properties of muscle manifested as a shift in the length-tension relationship towards longer muscle lengths. However, it is not clear whether this shift is a long term adaptation to eccentric exercise. The purpose of this study was to investigate functional adaptations to skeletal muscle damage in humans, tracking such responses several days into muscle recovery. Ten healthy young men performed an eccentric exercise protocol involving the quadriceps muscle and functional measurements were performed before and on days 1, 2, 5, 8, 12 and 16 post-exercise. Blood samples were also withdrawn before and at 6 h, and 2 days, 5 days and 16 days post-exercise. The exercise protocol resulted in muscle damage, indicated by changes in clinical markers including increased serum creatine kinase activity and muscle soreness compared to pre-exercise levels (p<0.05-0.001). An acute, but not sustained shift in the quadriceps isokinetic and isometric angle-torque curves towards longer muscle lengths was observed post-exercise (p<0.05). It was speculated that the functional adaptations following eccentric exercise might be affected by the short resting and functional length of the quadriceps muscle, relative to its optimum. More studies are needed to confirm the hypothesis that a sustained shift in the muscle's length-tension relationship, as an adaptation after lengthening contraction-induced damage, is muscle specific.

Muscular adaptation which occurs following eccentric exercise-induced muscle damage has been associated with changes in the mechanical properties of muscle manifested as a shift in the length-tension relationship towards longer muscle lengths. However, it is not clear whether this shift is a long term adaptation to eccentric exercise. The purpose of this study was to investigate functional adaptations to skeletal muscle damage in humans, tracking such responses several days into muscle recovery. Ten healthy young men performed an eccentric exercise protocol involving the quadriceps muscle and functional measurements were performed before and on days 1, 2, 5, 8, 12 and 16 post-exercise. Blood samples were also withdrawn before and at 6 h, and 2 days, 5 days and 16 days post-exercise. The exercise protocol resulted in muscle damage, indicated by changes in clinical markers including increased serum creatine kinase activity and muscle soreness compared to pre-exercise levels (p<0.05-0.001). An acute, but not sustained shift in the quadriceps isokinetic and isometric angle-torque curves towards longer muscle lengths was observed post-exercise (p<0.05). It was speculated that the functional adaptations following eccentric exercise might be affected by the short resting and functional length of the quadriceps muscle, relative to its optimum. More studies are needed to confirm the hypothesis that a sustained shift in the muscle's length-tension relationship, as an adaptation after lengthening contraction-induced damage, is muscle specific.

Clusterin/Apolipoprotein J (CLU) gene is expressed in most human tissues and encodes for two protein isoforms; a conventional heterodimeric secreted glycoprotein and a truncated nuclear form. CLU has been functionally implicated in several physiological processes as well as in many pathological conditions including ageing, diabetes, atherosclerosis, degenerative diseases, and tumorigenesis. A major link of all these, otherwise unrelated, diseases is that they are characterized by increased oxidative injury due to impaired balance between production and disposal of reactive oxygen or nitrogen species. Besides the aforementioned diseases, CLU gene is differentially regulated by a wide variety of stimuli which may also promote the production of reactive species including cytokines, interleukins, growth factors, heat shock, radiation, oxidants, and chemotherapeutic drugs. Although at low concentration reactive species may contribute to normal cell signaling and homeostasis, at increased amounts they promote genomic instability, chronic inflammation, lipid oxidation, and amorphous aggregation of target proteins predisposing thus cells for carcinogenesis or other age-related disorders. CLU seems to intervene to these processes due to its small heat-shock protein-like chaperone activity being demonstrated by its property to inhibit protein aggregation and precipitation, a main feature of oxidant injury. The combined presence of many potential regulatory elements in the CLU gene promoter, including a Heat-Shock Transcription Factor-1 and an Activator Protein-1 element, indicates that CLU gene is an extremely sensitive cellular biosensor of even minute alterations in the cellular oxidative load. This review focuses on CLU regulation by oxidative injury that is the common molecular link of most, if not all, pathological conditions where CLU has been functionally implicated. © 2009 Elsevier Inc.

OBJECTIVE: The aim of the present study was to estimate circulating oxidized low-density lipoprotein (oxLDL) levels in postmenopausal women and evaluate their association with obesity and smoking status. DESIGN AND METHODS: The study included 135 postmenopausal women aged 52-75 years. Forty of them were overweight (BMI 32.4+/-6.4) and non-smokers (Group A), 40 non-overweight (BMI 22.6+/-1.8) and smokers (Group B) and 55 non-overweight (BMI 23.5+/-1.4) and non-smokers (Group C). oxLDL and antibodies against them (anti-oxLDL) were measured using ELISA. Serum total cholesterol, LDL, HDL and triglycerides were measured in an automated analyzer. RESULTS: Total cholesterol, LDL, HDL and oxLDL serum levels were significantly elevated in Group A as compared to Group B or C, as well as oxLDL in Group B in comparison to Group C (p<0.001). Triglycerides and anti-oxLDL were increased in Group A in comparison to Group C (p=0.043 and 0.023). Total cholesterol, LDL, triglycerides and anti-oxLDL did not differ between Groups B and C, while HDL was decreased in Group B as compared to Group C (p<0.001). A significant positive correlation was found between oxLDL and LDL in Group A (r=0.53, p<0.001) as well as in Group C (r=0.955, p

BACKGROUND: Oxaliplatin has become one of the major cytotoxic agents for the treatment of gastrointestinal tumors. As a result, several cases of the so-called oxaliplatin-associated hypersensitivity reaction have been documented. PATIENTS AND METHODS: We have retrospectively evaluated and characterized these reactions in our patient group by reviewing the files of 1,224 patients exposed to an oxaliplatin-containing regimen in order to provide useful clinical information for diagnosis and management. RESULTS: Three hundred and eight (308) patients who have never been exposed to platinum compounds developed symptoms compatible with a reaction to oxaliplatin that was verified by manifestation of at least similar symptoms on rechallenging. The reactions occurred after the first 5 courses, with a median course number of 9 (range 1-24). These reactions could be distinguished as (1) mild reactions occurring in 195 (63%) patients manifesting with itching and small area erythema either during treatment or within the next hours, and (2) severe reactions occurring in 113 (37%) patients within minutes of drug infusion manifesting with diffuse erythroderma, facial swelling, chest tightness, bronchospasm and changes in blood pressure. Oxaliplatin withdrawal was not required in patients with a mild reaction. Forty-eight (42%) patients having a severe reaction with appropriate premedication and prolongation of the infusion duration could tolerate 2-4 subsequent courses. For the remaining 65 (58%) patients, oxaliplatin withdrawal was inevitable because of the very severe reactions occurring on rechallenging. In addition, 3 patients presented with thrombocytopenia and 3 others with hemolytic anemia, all reversible upon oxaliplatin discontinuation. CONCLUSIONS: Hypersensitivity reactions to oxaliplatin are underestimated. Although the reactions are not frequent during first courses, in extensively pretreated patients, they may become a serious problem. In the majority of patients, drug discontinuation might not be necessary. In patients manifesting a severe reaction, re-exposure to oxaliplatin should be considered only if the patient can tolerate the reaction and there has been clinical benefit from this therapy. Physicians and nursing staff should be aware of the risk and be well prepared.

Purpose of investigation: Primary fallopian tube carcinoma (PFTC) is a rare malignancy with only few data existing on the impact of prognostic factors. Methods: We retrospectively analyzed 26 patients. Tissue blocks were reviewed and sections were stained for vascular endothelial growth factor (VEGF), matrix metalloproteinases 2 and 9 (MMP-2, MMP-9), tissue inhibitors of metalloproteinases 1 and 2 (TIMP-1, TIMP-2), c-erbB-2, estrogen (ER), and progesterone receptors (PgR). Results: Reactivity for VEGF, ER, PgR, MMP-2, MMP-9, TIMP-1, TIMP-2 and c-erbB-2 was observed in 85%, 46%, 27%, 11.5%, 58%, 0%, 23% and 8% of specimens, respectively. None of the markers studied displayed prognostic significance. Regarding clinical prognostic factors, the hazard ratio (HR) for progression and death for patients with tumor residuum > 2 cm was 5.24 (p < 0.01) and 11.19 (p < 0.005), respectively. Patients with advanced stage disease had a HR of 12.55 (p < 0.05) for progression, while the HR for death was not found to be statistically significant. Conclusion: None of the biomarkers studied seems to influence survival. Early-stage disease and optimal debulking are associated with improved outcome.

The European Union Network for Patient Safety (EUNetPaS) is a project funded and supported by the European Commission within the 2007 Public Health Programme and aims to encourage and enhance the collaboration of participating EU countries in the field of Patient Safety. One of its major objectives is to promote Patient Safety (PS) education and training in Member States, through building a platform for mutual exchange of experience and knowledge on methods of planning and implementing sustainable learning activities. Towards this direction, a methodology has been applied, based on a three axes schema, which describes the roles, the awareness level and the competences of the PS Education and Training Activities. Based on this scheme, a questionnaire has been developed and distributed across EU organizations though National Contact Points, as a tool for information collection. Looking to the above structure, a web-based resource has been developed aiming to facilitate the information collection and sharing, in a truly networking environment.

Star clusters are valuable tools for theoretical and observational astronomy across a wide range of disciplines from cosmology to stellar spectroscopy. For example, properties of globular clusters are used to constrain stellar evolutionary models, nucleosynthesis and chemical evolution, as well as the star formation and assembly histories of galaxies and the distribution of dark matter in present-day galaxies. Open clusters are widely used as stellar laboratories for the study of specific stellar phenomena (e.g., various emission-line stars, pulsating pre-MS stars, magnetic massive stars, binarity, stellar rotation, etc.). They also provide observational constraints on models of massive star evolution and of Galactic disk formation and chemical evolution.

The relative contribution of the main mechanisms that control indoor air quality in residential flats was examined. Indoor and outdoor concentration measurements of different type pollutants (black carbon, SO 2, O 3, NO, NO 2,) were monitored in three naturally ventilated residential flats in Athens, Greece. At each apartment, experiments were conducted during the cold as well as during the warm period of the year. The controlling parameters of transport and deposition mechanisms were calculated from the experimental data. Deposition rates of the same pollutant differ according to the site (different construction characteristics) and to the measuring period for the same site (variations in relative humidity and differences in furnishing). Differences in the black carbon deposition rates were attributed to different black carbon size distributions. The highest deposition rates were observed for O 3 in the residential flats with the older construction and the highest humidity levels. The calculated parameters as well as the measured outdoor concentrations were used as input data of a one-compartment indoor air quality model, and the indoor concentrations, the production, and loss rates of the different pollutants were calculated. The model calculated concentrations are in good agreement with the measured values. Model simulations revealed that the mechanism that mainly affected the change rate of indoor black carbon concentrations was the transport from the outdoor environment, while the removal due to deposition was insignificant. During model simulations, it was also established that that the change rate of SO 2 concentrations was governed by the interaction between the transport and the deposition mechanisms while NO X concentrations were mainly controlled through photochemical reactions and the transport from outdoors. © 2009 Springer Science+Business Media B.V.

The aim of this study was to compare the efficacy and patient discomfort between four techniques for obtaining nasal secretions. Nasal secretions from 58 patients with symptoms of a common cold, from three clinical centers (Amsterdam, Lodz, Oslo), were obtained by four different methods: swab, aspirate, brush, and wash. In each patient all four sampling procedures were performed and patient discomfort was evaluated by a visual discomfort scale (scale 1-5) after each procedure. Single pathogen RT-PCRs for Rhinovirus (RV), Influenza virus and Adenovirus, and multiplex real-time PCR for RV, Enterovirus, Influenza virus, Adenovirus, Respiratory Syncytial Virus (RSV), Parainfluenza virus, Coronavirus, Metapneumovirus, Bocavirus and Parechovirus were performed in all samples. A specific viral cause of respiratory tract infection was determined in 48 patients (83%). In these, the detection rate for any virus was 88% (wash), 79% (aspirate), 77% (swab) and 74% (brush). The degree of discomfort reported was 2.54 for swabs, 2.63 for washes, 2.68 for aspirates and 3.61 for brushings. Nasal washes yielded the highest rate of viral detection without excessive patient discomfort. In contrast, nasal brushes produced the lowest detection rates and demonstrated the highest level of discomfort.

8-Oxo-7,8-dihydroguanine (8-oxo-G) is the major lesion of oxidatively generated DNA damage. Despite two decades of intense study, several fundamental properties remain to be defined. Its isoelectronic 8-aminoguanine (8-NH 2-G) has also received considerable attention from a biological point of view, although its chemistry involving redox processes remains to be discovered. We investigated the one-electron oxidation and one-electron reduction reactions of 8-oxo-G and 8-NH2-G derivatives. The reactions of hydrated electrons (eaq-) and azide radicals (N 3•) with both derivatives were studied by pulse radiolysis techniques, and the transient absorption spectra were assigned to specific tautomers computationally by means of time-dependent DFT (TD-B3LYP/6-311G**//B1B95/6-31+G**) calculations. The protonated electron adducts of 8-NH2-G and 8-oxo-G showed a substantial difference in their absorption spectra, the unpaired electron being mainly delocalized in the imidazolyl ring and in the six-membered ring, respectively. On the other hand, the deprotonated forms of one-electron oxidation of 8-NH2-G and 8-oxo-G showed quite similar spectral characteristics. In a parallel study, the one-electron reduction of 8-azidoguanine (8-N3-G) afforded the same transient of one-electron oxidation of 8-NH2-G, which represents another example of generation of one-electron oxidized guanine derivatives under reducing conditions. Moreover, the fate of transient species was investigated by radiolytic methods coupled with product studies and allowed self- and cross-termination rate constants associated with these reactions to be estimated. © 2009 American Chemical Society.

8-Oxo-7,8-dihydroguanine (8-oxo-G) is the major lesion of oxidatively generated DNA damage. Despite two decades of intense study, several fundamental properties remain to be defined. Its isoelectronic 8-aminoguanine (8-NH2-G) has also received considerable attention from a biological point of view, although its chemistry involving redox processes remains to be discovered. We investigated the one-electron oxidation and one-electron reduction reactions of 8-oxo-G and 8-NH2-G derivatives. The reactions of hydrated electrons (eaq−) and azide radicals (N3•) with both derivatives were studied by pulse radiolysis techniques, and the transient absorption spectra were assigned to specific tautomers computationally by means of time-dependent DFT (TD-B3LYP/6-311G**//B1B95/6-31+G**) calculations. The protonated electron adducts of 8-NH2-G and 8-oxo-G showed a substantial difference in their absorption spectra, the unpaired electron being mainly delocalized in the imidazolyl ring and in the six-membered ring, respectively. On the other hand, the deprotonated forms of one-electron oxidation of 8-NH2-G and 8-oxo-G showed quite similar spectral characteristics. In a parallel study, the one-electron reduction of 8-azidoguanine (8-N3-G) afforded the same transient of one-electron oxidation of 8-NH2-G, which represents another example of generation of one-electron oxidized guanine derivatives under reducing conditions. Moreover, the fate of transient species was investigated by radiolytic methods coupled with product studies and allowed self- and cross-termination rate constants associated with these reactions to be estimated.

To compare the performance of the reference scaled average bioequivalence(scABE(R)) method proposed by FDA scientists {[}Haidar et al., 2008. Pharm. Res. 25,237-241] with other approaches focusing on the human exposure expressed as the product sample size x periods of drug administration. Simulated bioequivalence studies were generated assuming the partial replicate 3-way crossover design and the classic (2 x 2) crossover design. Intrasubject variability (CV(W)) values ranged from 15% to 60% and sample sizes from 16 to 54. The procedures examined include: the scABER method. the classic 0.80-1.25 approach, a levelling-off scaled BE limit (BELscW), and some other scaled bioequivalence lit-nits. To assess the performance of the aforementioned approaches, the typical as well as novel three-dimensional modified power curves were constructed. A new index, termed %Mean Relative Difference (MRD%). was introduced in order to quantitatively compare the performance of the bioequivalence limits. The recently proposed scABER approach showed the lowest producer risk in particular for highly variable drugs. When exposure was taken into account scABER resulted in a desired behaviour when CV(W) was low. For high CV(W) values the overall performance diminished when geometric mean ratio (GMR) substantially deviated from unity. Application of the MRD% index clearly revealed that the effect of lowering the producer risk at GMR = I was totally Counterbalanced by the rise of consumer risk at high GMR values. The classic 0.80-1.25 limits were favoured at low intrasubject variability and high exposure, whereas the levelling-off limits demonstrated a preferred overall performance when variability was high and exposure was limited. (C) 2009 Elsevier B.V. All rights reserved.

A comprehensive theoretical study of the optical properties and switching competence of double-shell photonic crystals (DSPC) and doubleinverse-opal photonic crystals (DIOPC) is presented. Our analysis reveals that a DIOPC structure with a silicon (Si) background exhibits a complete photonic bandgap (PBG), which can be completely switched on and off by moving the core spheres inside the air pores of the inverse opal. We show that the size of this switchable PBG assumes a value of 3.78% upon judicious structural optimization, while its existence is almost independent of the radii of the interconnecting cylinders, whose sizes are difficult to control during the fabrication process. The Si-based DIOPC may thus offer a novel and practical route to complete PBG switching and optical functionality.

Zymomonas mobilis is an ethanol-producing alphaproteobacterium currently considered a major candidate organism for bioethanol production. Here we report the finished and annotated genome sequence of Z. mobilis subsp. mobilis strain NCIMB 11163, a British ale-infecting isolate. This is the first Z. mobilis strain whose genome, chromosomal and plasmid, is presented in its entirety.

Using Chandra, XMM-Newton and optical photometric catalogs we study the young X-ray binary (XRB) populations of the Small Magellanic Cloud (SMC). We find that the Be/X-ray binaries (Be-XRBs) are observed in regions with star-formation (SF) rate bursts ~30-70 Myr ago, which coincides with the age of maximum Be-star formation, while regions with strong but more recent SF (e.g., the Wing) are deficient in Be-XRBs. Using the 2dF spectrograph of the Anglo-Australian Telescope (AAT) we have obtained optical spectra of 20 High-Mass X-ray Binaries (HMXBs) in the SMC. All of these sources were proved to be Be-XRBs. Similar spectral-type distributions of Be-XRBs and Be field stars in the SMC have been found. On the other hand, the Be-XRBs in the Galaxy follow a different distribution than the isolated Be stars in the Galaxy, in agreement with previous studies.

In this study, we aimed to explore the factors related to acceptance of evolutionary theory among students/preservice preschool education teachers using conceptual ecology for biological evolution as a theoretical frame. We aimed to look into the acceptance and the understanding of evolutionary theory, and also to look into the relationship of the acceptance with understanding of evolutionary theory, parents’ educational level and frequency of church attendance as independent variables. Students’ restricted understanding of evolutionary theory is positively correlated with moderate acceptance of evolutionary theory but we did not find any significant positive correlation between parents’ educational level, religiosity and acceptance of evolution. Our findings indicate that studying a controversial issue such as the acceptance of evolutionary theory in a multivariate fashion, using conceptual ecology as a theoretical lens to interpret the findings, is informative. They also, indicate the differences that exist from society to society and how sociological factors as part of the conceptual ecology influence acceptance of evolution and have strong influence on Evolution education. And how useful is the enrichment of the Conceptual Ecology with other factors, i.e. thinking dispositions or making students familiar with the scientific method.

We confirm a nova candidate in M 31 reported to us by K. Nishiyama and F. Kabashima and present a pre-discovery detection that allows us to tightly constrain the time of outburst for this object. The nova candidate was discovered by Nishiyama and Kabashima (Miyaki-Argenteus observatory, Japan) on 2009 September 3.752 UT, with no object visible at its position on September 1.566 UT (private communication).

BACKGROUND: Vascular factors including medical history (heart disease, stroke, diabetes, and hypertension), smoking, and prediagnosis blood lipid measurements (cholesterol: total, high-density lipoprotein, low-density lipoprotein [LDL-C], and triglyceride concentrations) may be predictors for progression of Alzheimer disease (AD). OBJECTIVE: To determine whether prediagnosis vascular risk factors are associated with progression of AD. DESIGN: Inception cohort followed up longitudinally for a mean of 3.5 (up to 10.2) years. SETTING: Washington Heights/Inwood Columbia Aging Project, New York, New York. Patients One hundred fifty-six patients with incident AD (mean age at diagnosis, 83 years). Main Outcome Measure Change in a composite score of cognitive ability from diagnosis onward. RESULTS: In generalized estimating equation models (adjusted for age, race/ethnicity, and years of education), higher cholesterol (total cholesterol and LDL-C) concentrations and history of diabetes were associated with faster cognitive decline. Each 10-U increase in cholesterol and LDL-C was associated with a 0.10-SD decrease in cognitive score per year of follow-up (P < .001 for total cholesterol; P = .001 for LDL-C). High-density lipoprotein cholesterol and triglyceride concentrations were not associated with rate of decline. A history of diabetes was associated with an additional 0.05-SD decrease in cognitive score per year (P = .05). History of heart disease and stroke were associated with cognitive decline only in carriers of the apolipoprotein E epsilon4 (APOE-epsilon4) gene. In a final generalized estimating equation model that included high-density lipoprotein cholesterol and LDL-C concentrations and history of diabetes, only higher LDL-C was independently associated with faster cognitive decline. CONCLUSION: Higher prediagnosis total cholesterol and LDL-C concentrations and history of diabetes were associated with faster cognitive decline in patients with incident AD, which provides further evidence for the role of vascular risk factors in the course of AD.

The overall performance of a Volleyball team depends on many factors, from which decisive are considered to be the execution of skills that lead immediately to winning or losing the rally. These are lost serves, aces, kill- attacks, attack errors and kill-blocks. The analysis of these skills in relation to team performance, as expressed by the ratio of sets won to the total number of sets, lead to the formation of two new correlates. These are the serving efficiency ratio (SER), defined as the ratio of lost serves to aces, and the attack efficiency ratio (AER), defined as the number of kill attacks divided by the sum of attack errors and kill-blocks. Analysis of the data collected from all the matches of the male A1 volleyball professional league of 2005-2006 in Greece proved that the two efficiency ratios were better predictors of the teams overall performance than the five original variables. The findings lead to clear-cut definitions of norms both for the serving and attack efficiency ratio. The leading teams had a SER of around two and an AER of around three. These criteria are valuable tools especially for Volleyball coaches in deciding for the appropriate tactics of their teams.

CoPt and FePt compound films with L1(0) ordered structure have been intensively studied,due to their extremely high uniaxial magnetocrystalline anisotropy which makes them suitable for application in ultra high density magnetic recording media. A basic requirement in these type of media is the development of strong perpendicular magnetic anisotropy. The role of Ag underlayers in promoting strong (001) crystallographic texture and perpendicular magnetic anisotropy in post-annealed Ag/CoPt and Ag/FePt bilayers (BLs) has already been reported, along with a possible correlation between L1(0) formation and development of (001) crystallographic texture. In this work we present new data, which provide further evidence that there is indeed such a correlation during the annealing process of Ag/CoPt BLs. The most obvious manifestation of this correlation is the fact that the X-ray intensity ratios I-001/I-002 (used as a measure of the degree of L1(0)-ordering) and I-002/I-111 (used as a measure of the crystallographic texture) and the coercivity H-c and relative remnant magnetization m(r) (for field H normal to the surface of the films) exhibit the same kind of dependence from the thickness of the Ag underlayer. Comparison with respective crystallographic data from post-annealed Ag/CoPt nanocomposites (NCs) shows that in the case of NCs the (001) texture starts to degrade for lower total film thickness, compared to the case of BLs. This difference can be attributed to the structural incoherence in the growth of the CoPt grains imposed by the presence of Ag inside the Ag/CoPt NCs, while in BLs Ag is only used as an underlayer. Based on the above data and on detailed Heavy Ion Elastic Rutherford Back Scattering (HIRBS) measurements, performed on post-annealed Ag/CoPt NCs, we propose a possible mechanism for the interpretation of the observed correlation. The proposed mechanism is based on the reduction of total strain (residual strain of as-deposited film and transformation strain due to deformation of the unit cell as L1(0)-CoPt is formed) throughout the annealing process.

The parameter of health economics in the use of any contemporary medical module plays a dominant role in decision making. A prospective nonrandomised comparative study of the direct medical costs on the first attempt of treating aseptic nonunions of tibial fractures, with either autologous-iliac-crest-bone-graft (ICBG) or bone morphogenetic protein-7 (BMP-7), is presented. Twenty-seven consecutive patients, who were successfully treated for fracture nonunions, were divided into two groups. Group 1 (n = 12) received ICBG and group 2 (n = 15) received BMP-7. All patients healed their nonunions, and the financial analysis presented represents a best-case scenario. Three out of 12 of the ICBG group required revision surgery while just one out of 15 required it in the BMP-7 group. Average hospital stay was 10.66 vs. 8.66 days, time-to-union 6.9 vs. 5.5 months, hospitals costs pound2,133.6 vs. pound1,733.33, and theatre costs were pound2,413.3 vs. pound906.67 for the ICBG and BMP-7 groups, respectively. The BMP-7 cost was pound3002.2. Fixation-implant was pound696.4 vs. pound592.3, radiology pound570 vs. pound270, outpatient pound495.8 vs. pound223.33, and other costs were pound451.6 vs. pound566.27 for the ICBG and BMP-7 groups, respectively. The average cost of treatment with BMP-7 was 6.78% higher (P = 0.1) than with ICBG, and most of this (41.1%) was related to the actual price of the BMP-7. In addition to the satisfactory efficacy and safety of BMP-7 in comparison to the gold standard of ICBG, as documented in multiple studies, its cost effectiveness is advocated favourably in this analysis.

The sensitivity of regional air quality modeling simulations to boundary conditions over Greece is investigated, for various synoptic conditions. For this purpose, a global to mesoscale model-chain is developed and applied, coupling the individual models’ simulations. The global chemical transport model GEOS-CHEM, applied in a one-way nested procedure, is used to drive the regional UAM-V chemical dispersion model with time-varying lateral and top boundary conditions. The results of the coupling procedure are compared with the MINOS campaign measurements at Finokalia (Southern Greece) during the period from 1 to 16 August 2001 which is mainly characterized by an interchange of two synoptic types, High-Low and Long Wave trough. The comparison between the simulation results and the measurements reveals that the coupling procedure captures satisfactorily the range of observed CO concentrations at the southern part of Greece. The most severe deviations are observed under strongly variable atmospheric circulation, when no distinct synoptic circulation is allowed to be established in the area. Regarding O3, the highest, though underestimated, surface concentrations are simulated under Long Wave trough conditions due to the influence of the ozone inflow predicted by GEOS-CHEM at the western boundary of the innermost domain and/or under enhanced NOy emissions arriving at Finokalia from urban and ships plumes. © 2009 Elsevier Ltd. All rights reserved.

We began with discussions on what is gender, including a presentation of international dialogue on gender and the role of sport in addressing gender issues. Topics/lectures include: Doping and Gender, agency, the under-representation of women in competitive sports and in sport governing bodies (SGBs), the social gender and sport identity, the sport-gender imbalance, Women athletes in the mass media, genderless athletes, Olympism or peace education, underdevelopment of sport in developing countries, racism and xenophobia in sport, child exploitation and child protection in sport, gender and leadership skills, and so on. Gender refers to the socially-constructed roles of and relationships between men and women. Gender concerns men and women, including conceptions of both femininity and masculinity. The difference between ‘gender’ and ‘sex’ is that the latter refers only to biological differences as an analytical category. Gender does not mean focusing solely on women or females, but rather on the inequalities regarding both genders, and should not be confused with feminism or women’s studies. However, analyses of gender differences often show a socially disadvantaged and weaker position of women and girls in social, political, economic, legal, educational and sport issues. This is why there is a tendency for gender discussions and interventions to focus on correcting these imbalances by specifically targeting women and girls. More analytically with regard to the course content see links]............................................... _________________________________________________________________________________________-Initially, discussions on what is gender, presentation of international dialogue on gender and the role of sport in addressing gender issues. Topics/lectures include: Doping and Gender, agency, the under-representation of women in competitive sports and in sport governing bodies (SGBs), the social gender and sport identity, the sport-gender imbalance, Women athletes in the mass media, genderless athletes, Olympism or peace education, underdevelopment of sport in developing countries, racism and xenophobia in sport, child exploitation and child protection in sport, gender and leadership skills, and so on.   More analytically with regard to the course content see attachment........................................when citing: Kamberidou, I., & Karteroliotis, K. (2009). “Course Proposal for Postgraduate Interdisciplinary Education of Women”. Presentation at the international workshop of the project “Estia-Earth to Sustain Women’s Careers as Academics, Researchers and Professionals in Engineering, Computer and the. In “Estia-Earth to Sustain Women’s Careers as Academics, Researchers and Professionals in Engineering, Computer and the Sciences, Lifelong Learning Erasmus Network” (partner: Faculty of Physical Education and Sport Science, Athens Greece). "1st Expert Meeting “Development of MSc Programs” & Jointly the 3rd International steering Committee Meeting ESTIA-EARTH", Venue: Polytechnic University of Bucharest, Nov. 20-21, 2009. (www.estia.net).  DOI: 10.13140/RG.2.1.3256.0489V    

Background Renal impairment is a common complication of multiple myeloma. Cystatin-C is considered an accurate marker of glomerular filtration rate in several renal disorders. Microarray analysis has revealed that cystatin-C is one of the most highly up-regulated genes in multiple myeloma. The aim of this study was to evaluate the serum levels of cystatin-C in myeloma patients, explore possible correlations with clinical data, including survival, and assess the effect of bortezomib on cystatin-C in relapsed multiple myeloma. Results We measured serum cystatin-C in 157 newly diagnosed, previously untreated myeloma patients, in 28 patients with relapsed disease pre- and post-bortezomib therapy and in 52 healthy controls, using a latex particle-enhanced nephelometric immunoassay. Results In newly diagnosed patients, cystatin-C was elevated and showed strong correlations with advanced ISS stage, extensive bone disease, high ffc-microglobulin, high serum creatinine, and low creatinine clearance. Multivariate analysis revealed that only cystatin-C and lactate dehydrogenase had an independent prognostic impact on patients' survival. The combination of cystatin-C and lactate dehydrogenase revealed three prognostic groups of patients: a high-risk group (both elevated cystatin-C and lactate dehydrogenase) with a median survival of 24 months, an intermediate-risk group (elevated cystatin-C or elevated lactate dehydrogenase) with a median survival of 48 months and a low-risk group (both low cystatin-C and lactate dehydrogenase) in which median survival has not yet been reached (p<0.001). Cystatin-C could also identify a subset of ISS-II patients with worse outcome. Relapsed patients had higher cystatin-C levels even compared to newly diagnosed patients. Treatment with bortezomib produced a significant reduction of cystatin- C, mainly in responders. Conclusions Serum cystatin-C is not only a sensitive marker of renal impairment but also reflects tumor burden and is of prognostic value in myeloma. Its reduction after treatment with bortezomib reflects bortezomib's anti-myeloma activity and possibly bortezomib's direct effect on renal function. © 2009 Ferrata Storti Foundation.

Dendritic cells (DCs) are major antigen-presenting cells that constitute a link between innate and adaptive immune responses, and are critical in the processes of control and elimination of viral infections. On the other hand, there is a large body of data strongly implicating respiratory viruses in morbidity during infancy through the induction of lower respiratory tract infections, such as bronchiolitis, and later on in childhood and adult life, mainly due to their association with asthma exacerbations. Little is known, however, about the precise role of DCs in human respiratory tract infections. This review focuses on current data, both from in vivo and in vitro studies, that highlight the interplay between DCs and the viral causes of bronchiolitis.

One of the most common cancer types among women is breast cancer. Regular mammographic examinations increase the possibility for early diagnosis and treatment and significantly improve the chance of survival for patients with breast cancer. Keeping an informed and complete patient record is of great importance as the doctor needs this information for every patient examination. The proposed implementation is a patient record system that includes 'smart' algorithms in order to automatically use data from the patient's record to calculate well established epidemiological breast cancer models. A computer-aided diagnosis system is also used in order to analyze each mammogram and obtain a certain risk percentage concerning whether the patient has to undergo biopsy or not. The aforementioned system has been implemented to support a large set of patient data (1,178 patients) which included detailed personal patient data, medical history and examination details per date and is used in the daily clinical practice of a breast cancer diagnostic center facilitating patient record retrieval, storage and supporting the doctor's decisions.

Previous studies showed that high levels of human immunodeficiency virus type 1 (HIV-1) DNA are associated with a faster progression to AIDS, an increased risk of death, and a higher risk of HIV RNA rebound in patients on highly active antiretroviral therapy. Our objective was to develop and assess a highly sensitive real-time multiplex PCR assay for the quantification of HIV-1 DNA (RTMP-HIV) based on molecular beacons. HIV-1 DNA quantification was carried out by RTMP in a LightCycler 2.0 apparatus. HIV-1 DNA was quantified in parallel with CCR5 as a reference gene, and reported values are numbers of HIV-1 DNA copies/10(6) peripheral blood mononuclear cells (PBMCs). The clinical sensitivity of the assay was assessed for 115 newly diagnosed HIV-1-infected individuals. The analytical sensitivity was estimated to be 12.5 copies of HIV-1 DNA per 10(6) PBMCs, while the clinical sensitivity was 100%, with levels ranging from 1.23 to 4.25 log(10) HIV-1 DNA copies/10(6) PBMCs. In conclusion, we developed and assessed a new RTMP-HIV assay based on molecular beacons, using a LightCycler 2.0 instrument. This multiplex assay has comparable sensitivity, reproducibility, and accuracy to single real-time PCR assays.

OBJECTIVE: The FcgammaRIIa receptor is responsible for the activation of platelets by antibodies in heparin-induced thrombocytopenia (HIT). The c.497G>A polymorphism in the corresponding FCG2RA gene (H131R) has been implicated in the HIT syndrome and we aimed at its rapid and reliable determination. DESIGN AND METHODS: We designed a novel asymmetric real-time PCR method in the LightCycler that uses two hybridization probes and is followed by melting curve analysis. Seventy-one post-cardiac-surgery HIT Greek patients well ascertained by clinical data, immunological and functional tests (PAT, CD62P-selectin and microparticle flow cytometric detection) were studied, along with a clinically relevant group of 49 thrombocytopenic control patients and 119 healthy subjects. RESULTS: The developed method has excellent analytical characteristics (linear and efficient amplification, precision), has wide DeltaT(m) between the two alleles H and R (11.53 degrees C), and is in 100% concordance with validated controls and another commonly used screening method. The RR percentage increased from 10% in the control populations to 24% in the HIT patient group. CONCLUSION: The described method is technically simple, robust, fast, and accurate. A statistically significant difference was found in the comparison between the groups of HIT patients and healthy subjects [RR vs. RH+ HH, chi(2) test, p=0.01, OR (95% C.I.) 2.81 (1.21-4.68)]. The RR frequency in the Greek population was found to be the lowest among Caucasians

Hypertension may complicate treatment with antiangiogenic agents, leading to dose reductions and treatment delays. To prospectively evaluate the frequency and management of hypertension in 10 patients with advanced kidney cancer receiving sunitinib, we used 24-h blood pressure monitoring (BPM) and home BPM and homogenously treated hypertension according to guidelines of the European Society of Hypertension. Normal BP was ensured prior to sunitinib initiation with the successive use of hydrochlorothiazide + irbesartan, nebivolol, amlodipine. During treatment, additional antihypertensive therapy was introduced, if necessary. Sunitinib dose was modified only if BP was not controlled with four anti-hypertensive agents. Four patients had baseline hypertension, while 5 of 6 normotensive patients required antihypertensive treatment during sunitinib administration. One patient permanently discontinued sunitinib due to hypertensive crisis but 9 patients received full dose. Sunitinib-associated hypertension is more frequent than previously reported. Aggressive BP monitoring and treatment of hypertension may achieve uninterrupted, full-dose therapy in most patients treated with sunitinib. The application of such protocols instead of commonly used toxicity criteria should be further validated. © E.S.I.F.T. srl.

Bone disease remains a major problem in the management of patients with multiple myeloma (MM) and is characterized by the presence of lytic lesions due to increased osteoclastic activity and reduced osteoblast function. Wingless-type and integrase 1 (Wnt)/β-catenin signaling is a central pathway for bone development and homeostasis. Dickkopf-1 (Dkk-1) is a soluble inhibitor of Wnt, which disrupts osteoblast differentiation and action. Dkk-1 is produced by myeloma cells and overexpressed in myeloma microenvironment of patients with extensive bone disease. In addition to its direct inhibitory effect of Dkk-1 on osteoblasts, Dkk-1 disrupts the Wnt3a-regulated osteoprotegerin and receptor activator of NF-κB ligand (RANKL) expression in osteoblasts and thus it indirectly enhances osteoclast function in MM. Dkk-1 serum and bone marrow plasma levels are increased in MM patients and correlated with advanced International Staging System stage and presence of osteolytic lesions. Preclinical studies in mouse myeloma models showed that targeting Dkk-1 with neutralizing anti-Dkk-1 antibodies resulted in increased numbers of osteoblasts, reduced numbers of multinucleated osteoclasts and increased bone volume. The bone anabolic effect of anti-Dkk-1 may also be associated with reduced myeloma burden. These data show that Dkk-1 has a pivotal role in bone health and disease and is a novel target for the management of myeloma patients with lytic bone disease. © 2009 Informa UK Ltd. All rights reserved.

Data concerning the efficacy of PEG-IFN alpha 2a plus ribavirin treatment in treatment-naive, genotype 4-infected chronic hepatitis C (CHC) patients from Europe are limited. Hence the aim of this study was to investigate the viral kinetics as well as the sustained virological response (SVR) rates and their predictors, in these patients. One hundred and twenty-three patients were retrospectively analysed. Early (EVR) and late virological response (LVR) was confirmed by undetectable (<50 IU/mL) serum HCV-RNA at week 12 and week 24 of treatment, respectively. SVR was confirmed by undetectable serum HCV-RNA at the end of treatment as well as 6 months later. Overall, 43.5% of patients exhibited SVR, 42.6% were nonresponders and 13.9% were relapsers. EVR was observed in 40.74% and LVR in 59.25% of them. The positive predictive values of EVR and LVR were 72.97% and 86.27% whereas their negative predictive values were 64.29% and 92.85%, respectively. EVR independently predicted SVR in Caucasian patients (P < 0.001) but not in Egyptian patients (P = 0.613), in whom the only independent predictor of SVR was the absence of cirrhosis (P = 0.004). LVR seems to be a better predictor of SVR than EVR in the vast majority of genotype 4-infected CHC patients, irrespective of ethnicity and all the other baseline parameters.

The phospholipase A2 (PLA2) superfamily hydrolyzes phospholipids to release free fatty acids and lysophospholipids, some of which can mediate inflammation and demyelination, hallmarks of the CNS autoimmune disease multiple sclerosis. The expression of two of the intracellular PLA2s (cPLA2 GIVA and iPLA2 GVIA) and two of the secreted PLA2s (sPLA2 GIIA and sPLA2 GV) are increased in different stages of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. We show using small molecule inhibitors, that cPLA2 GIVA plays a role in the onset, and iPLA2 GVIA in the onset and progression of EAE. We also show a potential role for sPLA2 in the later remission phase. These studies demonstrate that selective inhibition of iPLA2 can ameliorate disease progression when treatment is started before or after the onset of symptoms. The effects of these inhibitors on lesion burden, chemokine and cytokine expression as well as on the lipid profile provide insights into their potential modes of action. iPLA2 is also expressed by macrophages and other immune cells in multiple sclerosis lesions. Our results therefore suggest that iPLA2 might be an excellent target to block for the treatment of CNS autoimmune diseases, such as multiple sclerosis.

AIMS: To study circulating levels and distribution of adiponectin multimers [low molecular weight (LMW)-, medium molecular weight (MMW)- and high molecular weight (HMW)-adiponectin] in preterm and full-term infants. METHODS: Total serum adiponectin and its multimers were measured in 40 healthy infants at the age of one month and associations with anthropometric parameters [body weight and length, body mass index (BMI)], weight gain and metabolic indices (glucose, insulin) were examined. Twenty of the infants were born preterm (gestational age 33.2+/-1.6 weeks). RESULTS: LMW-adiponectin level and its fractional ratio to total adiponectin were significantly higher in full-term than in preterm infants (P<0.001 and P<0.01, respectively), whereas, MMW-adiponectin level and its ratio were significantly lower (P=0.03 and P=0.01, respectively). HMW-adiponectin did not differ significantly between full-term and preterm infants and accounted for almost 60% of total adiponectin levels in both groups. HMW-adiponectin, but not MMW adiponectin or LMW adiponectin, correlated significantly with anthropometric measurements, similarly to total adiponectin; in addition, HMW adiponectin correlated significantly with weight gain. CONCLUSIONS: HMW adiponectin is the most prevalent form in infants. Circulating levels and distribution of MMW- and LMW-adiponectin differ between full-term and preterm infants, but the role of these adiponectin multimers needs to be studied further.

Division VII gathers astronomers studying the diffuse matter in space between stars, ranging from primordial intergalactic clouds, via dust and neutral and ionized gas in galaxies, to the densest molecular clouds and the processes by which stars are formed.

Self-organized porous TiO2 nanotubes (NTs) were prepared on conductive glass by galvanostatic anodizing of sputtered titanium in an NH 4F /glycerol electrolyte. DC magnetron sputtering at an elevated substrate temperature (500 °C) was used to deposit 650nm thick titanium films. After anodizing, NTs, 830nm long, with an average external diameter of 92nm, were grown; this gave a high conversion rate of oxide from titanium (1.9), with a 220nm thick layer of titanium, which was not oxidized, located at the base of the tubes. The NTs revealed a mainly amorphous structure, which transformed mostly to anatase upon thermal treatment in air at 450 °C. The tubes were sensitized by the N719 complex and the resultant photoelectrodes were incorporated into liquid dye solar cells (DSCs) and further tested under back-side illumination. High values of Voc (714mV) were obtained under 1 sun (AM 1.5), assigned to low dark current magnitude and large recombination resistance and electron lifetime. In addition, typical values of fill factors (of the order of 0.62) were attained, in agreement with the estimated ohmic resistance of the cells in combination with low electron transfer resistance at the platinum/electrolyte interface. The overall moderate power conversion efficiency (of the order of 0.3%) was mainly due to the low short-circuit photocurrents (Jsc = 0.68mAcm-2), which was confirmed further by the corresponding IPCE values (5.2% at 510nm). The magnitude of Jsc was attributed to absorbed light losses due to back-side illumination of the cells, the low dye loading (due to the limited thickness of anodic titania) and the high charge transfer resistance at the TiO2 /conductive substrate due to the presence of barrier layer(s) underneath the tubes. These preliminary results encourage the DSC community to explore further the galvanostatic anodizing of titanium in order to produce highly efficient porous TiO2 NTs directly on conductive glass. Current work is focusing on achieving complete anodizing of the metal substrate and full transparency for the photoelectrode in order to increase and optimize the resultant cell efficiencies. © 2009 IOP Publishing Ltd.

Current approaches to syntactic derivation capitalize on the notion of syntactic cycles either in the sense of phases (Chomsky 2000) or derivational cascades (Uriagereka 1999). Such models raise some interesting issues regarding the way in which phonology processes the syntactic output. In this paper we propose that the derivational status of syntactic material is reflected on the way PF organizes the output of syntax into phonological phrases. More specifically, based on evidence from the prosodification of clitic-doubled DP-objects in Greek, we argue that elements which exhibit derivational islandhood form independent phonological phrases and, significantly, are impervious to PF restructuring mechanisms. We further explore the limits of this isomorphism by investigating the derivational and prosodic status of preverbal Greek subjects and conclude that their syntactic non-islandhood is matched by an analogous behavior at the PF since they are subject to restructuring. This particular type of isomorphism provides empirical justification for drawing a distinction between two different implementations of Spell-Out, as originally proposed in Uriagereka (1999).

A simple, safe and cost-effective treatment protocol in ovarian stimulation is of great importance in IVF practice, especially in the case of previous unsuccessful attempts. hCG has been used as a substitute of LH because of the degree of homology between the two hormones. The main aim of this prospective randomized study was to determine, for the first time, whether low dose hCG added to rFSH for ovarian stimulation could produce better results compared to the addition of rLH in women entering IVF-ET, especially in those women that had previous IVF failures. An additional aim was to find an indicator that would allow us to follow-up ovarian stimulation and, possibly, modify it in order to achieve a better IVF outcome; and that indicator may be the cDNA copies of the LH/hCG receptor. Group A patients (n = 58) were administered hCG and Group B rLH (n = 56) in addition to rFSH in the first days of ovarian stimulation. The number of follicles and oocytes and, most importantly, implantation and pregnancy rates were shown to be statistically significantly higher in the hCG group. This study has also determined, for the first time to our best knowledge, m-RNA for LH/hCG receptors in the lymphocytes of peripheral blood 40 h before ovum pick-up. cDNA levels of the hCG receptor after ovarian stimulation were significantly higher among women receiving hCG compared to those receiving LH. In addition, higher levels were encountered among women with pregnancy compared to those without, although this was not statistically significant due to the small number of pregnancies. It seems that hCG permits a highly effective and more stable occupancy of rLH/hCG receptors and gives more follicles and more oocytes. The determination of cDNA copies could be, in the future, a marker during ovulation induction protocols and of course a predictor for the outcome of ART in the special subgroup of patients with previous failures.

We describe a patient in whom an initially intact sciatic nerve became rapidly encased in heterotopic bone formed in the abductor compartment after reconstruction of the posterior wall of the acetabulum following fracture. Prompt excision and neural release followed by irradiation and administration of indometacin resulted in a full neurological recovery and no recurrence 27 months later.

Hip resurfacing has recently been offered as an attractive alternative to conventional total hip arthroplasty. This report evaluated the short-term functional outcome and longevity of a newer generation resurfacing device and includes the results of 228 consecutive hip resurfacing in 209 patients at a minimum of two-year follow-up. All resurfacing were performed by a single surgeon using a posterior approach. Excluding infections, there were only three failures (1.3%). The overall survival at 4.6 years was 96.9%. The survival of resurfacing in this study was comparable to that of other published studies of hip resurfacing. Surface hip arthroplasty appears to be an effective alternative to conventional total hip arthroplasty in patients suffering from osteoarthritis.

A commercially available powder of MgB2 is used as starting material for the examination of the influence of the annealing temperature on the properties of this intermediate-T-c superconductor. We performed scanning electron microscopy (SEM) and Hall ac-susceptibility measurements as a function of temperature and ac-field amplitude on samples annealed at 650, 750, 850 and 950 degrees C. The imaginary part of ac-susceptibility measurements is used to calculate both the inter-granular critical current density, J(c)(T-p) and density of pinning force, alpha(j)(0). It was observed that all T-c, J(c)(T-p) and alpha(j)(0) exhibit a non-monotonic behavior on the annealing temperature range studied in this work. T-c is measured to be 39.85 +/- 0.02 K and J(c)(T-p) is estimated to be as high as 60 A/cm(2) at 39.2 K for the sample annealed at 850 degrees C. The peak temperature, T-p, in the imaginary part of the ac-susceptibility curves shifts to lower temperatures with both decreasing the annealing temperature and increasing the amplitude of the ac-magnetic fields. A comparison of the experimental ac-susceptibility data with theoretical critical-state models that are currently available is performed. SEM investigations showed that the grain size increases, and the grain connectivity improves when the annealing temperature increases up to 850 degrees C. The possible reasons for the observed changes in transport, microstructure and magnetic properties due to annealing temperature are discussed. (C) 2009 Elsevier B.V. All rights reserved.

Praziquantel (PZQ), the primary drug of choice in the treatment of schistosomiasis, is a highly lipophilic drug that possesses high permeability and low aqueous solubility and is, therefore, classified as a Class II drug according to the Biopharmaceutics Classification System (BCS). In this work, beta-cyclodextrin (beta-CD) and hydroxypropyl-beta-cyclodextrin (HP-beta-CD) were used in order to determine whether increasing the aqueous solubility of a drug by complexation with CDs, a BCS-Class II compound like PZQ could behave as BCS-Class I (highly soluble/highly permeable) drug. Phase solubility and the kneading and lyophilization techniques were used for inclusion complex preparation; solubility was determined by UV spectroscopy. The ability of the water soluble polymer polyvinylpyrolidone (PVP) to increase the complexation and solubilization efficiency of beta-CD and HP-beta-CD for PZQ was examined. Results showed significant improvement of PZQ solubility in the presence of both cyclodextrins but no additional effect in the presence of PVP. The solubility/dose ratios values of PZQ-cyclodextrin complexes calculated considering the low (150 mg) and the high dose (600 mg) of PZQ, used in practice, indicate that PZQ complexation with CDs may result in drug dosage forms that would behave as a BCS-Class I depending on the administered dose.

Different silicon nanocrystal (Si NC) systems in which Si NCs were either entirely isolated or loosely interconnected were studied by photoluminescence (PL) and time-resolved PL decay measurements in the range between 70 and 290 K, in order to investigate the role of exciton migration in the PL properties. We examined three kinds of samples: (a) two light emitting mesoporous Si (PSi) films with different porosities, grown on p -type Si, (b) a heavily oxidized light emitting anisotropic macroporous Si film, and (c) a film consisted of a Si NC superlattice with six Si NC/ SiO2 bilayers, grown by low pressure chemical vapor deposition of amorphous Si (α-Si), followed by high temperature thermal oxidation. In the two mesoporous Si films of the first case, the Si NCs show a degree of interconnection that depends on the porosity, whereas in the two other cases the NCs were isolated by SiO2, the degree of electrical isolation depending on the thickness of the SiO2 interlayer between them. Temperature dependent PL spectra and PL decay times of the different systems correlate well with the ability of excitons to migrate from one NC to another (case of loosely correlated NCs) or remain strongly localized within the Si NCs (case of effectively isolated NCs). © 2009 American Institute of Physics.

BACKGROUND: Several reports have shown that homocysteine promotes thrombosis by disturbing the procoagulant-anticoagulant balance, whereas alterations in coagulation and fibrinolysis have been suggested as important pathogenetic and prognostic determinants of mortality in acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). The objective of the study was to evaluate the effect of plasma homocysteine levels on the outcomes of patients with ALI/ARDS. METHODS: Sixty-nine consecutive ventilated patients with ALI/ARDS were studied. Blood samples were drawn within 3 days of clinical recognition of ARDS. Measurement of plasma homocysteine, vitamin B12, folate, creatinine, protein C and plasminogen-activator inhibitor-1 antigen levels, and genotyping of the methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms were carried out. The primary outcomes were 28- and 90-day mortality, whereas secondary outcomes included nonpulmonary organ failure-free days, liberation from mechanical ventilation up to day 28, and ventilator-free days during the 28 days after enrollment. RESULTS: In the multivariable analysis, plasma homocysteine concentration adjusted for age, Acute Physiology and Chronic Health Evaluation II score, methylenetetrahydrofolate reductase C677T and A1298C polymorphisms, and levels of plasminogen-activator inhibitor-1 antigen, protein C, creatinine, vitamin B12, and folate was not found to affect significantly mortality at 28 and 90 days (P = 0.39 and P = 0.83, respectively), days without organ failure besides lungs (P = 0.38), the probability of being free from mechanical ventilation at day 28 (P = 0.63), and days without ventilation assistance (P = 0.73). CONCLUSION: Our data suggest that increased plasma homocysteine levels, either alone or in synergy with other thrombophilic risk factors, do not seem to adversely affect the prognosis in patients with ALI/ARDS

Stellar winds seem to be very efficient at removing angular momentum from stars. By means of analytical axisymmetric solutions of the ideal MHD equations for steady outflows, we show via a specific example how collimated stellar winds can brake Weak T Tauri stars in a reasonable time. This result can be generalized to Classical T Tauri stars provided that part of the accreted angular momentum is removed by the inner disk wind. We also extend briefly to Kerr metrics the self similar MHD solutions for relativistic flows and conjecture that relativistic outflows may efficiently slow down spinning black holes at the center of Active Galactic Nuclei or microquasars.

Stellar winds seem to be very efficient at removing angular momentum from stars. By means of analytical axisymmetric solutions of the ideal MHD equations for steady outflows, we show via a specific example how collimated stellar winds can brake Weak T Tauri stars in a reasonable time. This result can be generalized to Classical T Tauri stars provided that part of the accreted angular momentum is removed by the inner disk wind. We also extend briefly to Kerr metrics the self similar MHD solutions for relativistic flows and conjecture that relativistic outflows may efficiently slow down spinning black holes at the center of Active Galactic Nuclei or microquasars.

THE EFFECT OF THE STARTING LINE-UP OF THE PLAYERS ON THE OUTCOME OF THE SET IN VOLLEYBALL.Laios. A.,  Kountouris. P.,  Laios. Y., Drikos. S.Faculty of Physical Education and Sport Science, University of AthensOne of the peculiarities of the game of Volleyball is its rotation system. Before the beginning of every set the team coach must give to the referees in written form the starting positions of the six players of his team. During the set, every time the team wins a rally served by the opponent all its players shift their positions in a clockwise manner 1→6→5→4→3→2→1. During position shifts the relative positions of the players do not change. A complete rotation of the team is achieved after six position shifts, whence the players are again in the same positions as the starting line-up. After the application of the rally point system the number of rallies played per set (except the fifth one) was significantly reduced. The aim of the present study was to examine the distribution of the number of position shifts per set in various situations, with the intention to infer whether this information may prove to have practical importance. The primary data were collected from the Greek Men’s Volleyball Championship of 2005-2006 with the participation of twelve teams in a two round system. This gives a total of 132 matches, in which 491 sets were played. The primary dependent variable was the number of position shifts of the winning team. Its distribution was examined in different kinds of sets (first four or fifth) and in different outcomes of the set, measured as point differences between the winning and the losing team. For the first four sets the mean value of position shifts was 14.8±2.8 with only 6.8% of the sets having position shifts equal to or greater than 18. Even in the sets with a minimum difference between the two teams (25-23) and therefore a maximum number of points, the mean value of position shifts was 16.4±1.7 with only 9.1% of the sets having position shifts equal to or greater than 18. For the fifth set the mean value of position shifts was 9.0±2.3 with only 3.1% of the sets having position shifts equal to or greater than 12. Therefore the number of complete rotations for the first four sets was around two-and-a-half and the number of complete rotations for the fifth set was around one-and-a-half. In a previous research it was found that there seem to be favourable situations during position shifts, when the serving team has increased chances of winning the point. Since most probably during a set a team will not complete a whole number of complete rotations, the coach should start the set with the most favoured positions coming up first, or at least in the middle, but certainly not last. This will guarantee that the favoured positions will appear more frequently and most probably at crucial points at the end of the set. This is especially important in view of the fact that the winning team must win at least two more points than its opponent when serving, with the odds of winning against losing the rally when serving being only one to two.

Landbridge islands offer unique opportunities for understanding the effects of fragmentation history on genetic variation in island taxa. The formation of islands by rising sea levels can be likened to a population bottleneck whose magnitude and duration is determined by island area and time since isolation, respectively. The Holocene landbridge islands of the Aegean Sea (Greece) were formed since the last glacial maximum and constitute an ideal system for disentangling the effects of island area, age and geographic isolation on genetic variability. Of the many reptile species inhabiting this island system, the Aegean wall lizard Podarcis erhardii is an excellent indicator of fragmentation history due to its widespread distribution and poor over-water dispersal abilities. In this study, we utilize a detailed record of Holocene fragmentation to investigate the effects of island history on wall lizard mitochondrial and nuclear microsatellite diversity. Findings show that the spatial distribution of mitochondrial haplotypes reflects historical patterns of fragmentation rather than geographic proximity per se. In keeping with neutral bottleneck theory, larger and younger islands retain more nuclear genetic variation than smaller, older islands. Conversely, there is no evidence of an effect of isolation by distance or effect of distance to the nearest larger landmass on genetic variability, indicating little gene flow between islands. Lastly, population-specific measures of genetic differentiation are inversely correlated with island area, suggesting that smaller islands exhibit greater divergence due to their greater susceptibility to drift. Taken together, these results suggest that both island area and time since isolation are important predictors of genetic variation and that these patterns likely arose through the progressive fragmentation of ancestral diversity and the ensuing cumulative effects of drift.

To determine the effect of montelukast on asthma during the allergy season in children with persistent asthma and seasonal aeroallergen sensitivity.|This 3-week double-blind, placebo-controlled, parallel-group multicenter study compared daily montelukast 5 mg chewable tablets and placebo in patients 6-14 years of age with forced expiratory volume in 1 second (FEV(1)) > or = 60 and < or = 85% predicted, persistent asthma that is also active during allergy season, and documented sensitivity to seasonal allergens. Concomitant inhaled corticosteroid use was permitted in up to 40% of enrolled patients. The primary endpoint was the percentage change from baseline in FEV(1) over 3 weeks of treatment. Additional endpoints included the percentage change from baseline in beta-agonist use, average changes in daytime and nighttime symptom score, AM and PM peak expiratory flow rate (PEFR), investigator's global asthma evaluation, and parent/guardian global asthma evaluation at the end of the treatment period. Adverse experiences (AEs) were collected to assess safety and tolerability.|A total of 421 patients were randomized to montelukast (N = 203) or placebo (N = 218). For the primary endpoint, the percentage change from baseline FEV(1), montelukast was not significantly different from placebo (least squares mean 9.53% vs. 9.15%, respectively; p = 0.810). Compared with placebo, montelukast was associated with significantly lower (better) investigator's global asthma evaluation (LS mean 2.71 vs. 2.98; p < 0.05) and parent/guardian global asthma evaluation (LS mean: 2.63 vs. 2.90; p < 0.05) scores. There were no significant differences between treatment groups for the other efficacy evaluations. Both treatments were well tolerated, with no significant differences observed in AE rates.|Montelukast did not significantly improve FEV(1) compared with placebo over three weeks of treatment during the allergy season in pediatric patients with seasonal allergen sensitivity. (ClinicalTrials.gov identifier: NCT00289874).

The elaboration of analytical microzoning studies involves a multidisciplinary approach comprising geological, geotechnical, seismological, geophysical and dynamic soil analysis data. In an attempt to incorporate the maximum available amount of information and in the view of the continuously expanding use of GIS, as a tool for analyzing and integrating data, a new software environment called AUTO-SEISMO-GEOTECH has been developed for handling these multi-parameter data. This user friendly package is presently implemented for the cities of Heraklion (Crete island- province of Heraklion) and Thiva (province of Viotia) in Greece. The pilot methodologies applied in these urban areas, aimed also at determining a minimum package of tasks/methods needed for the elaboration of a microzoning study, are described and evaluated here. Next, a database with appropriate architecture was formed in order to handle all available geo-information for each city separately and produce thematic maps, such as geological, tectonic, hydrogeological, seismic hazard and microzonation ones. These maps can be easily reproduced, integrated and used for building safer constructions contributing so to mitigation of earthquake consequences. Geo-information obtained by a) existing regional seismicity maps and installation of local portable seismographic networks around both cities, to monitor the microseismic activity and define possible active fault zones, b) geological mapping of the broader urban area in scale 1:5000, c) evaluation of existing geotechnical data as well as new data coming from boreholes, d) geophysical data resulting from surface and borehole techniques, for Vp, Vs and dynamic elastic parameters estimation and e) consideration of historical seismological data for seismic hazard estimation, have been incorporated in this GIS based platform, to be easily handled for further use. The output of this information combined with the dynamic soil analysis produces detailed microzonation maps. Such maps are valuable for city planners and urban designers.

A novel parametrization within a simplified LCAO model (a type of Hückel model) is presented for the description of π molecular orbitals in organic molecules containing π-bonds between carbon, nitrogen, or oxygen atoms with sp2 hybridization. It is shown that the model is quite accurate in predicting the energy of the highest occupied π orbital and the first π–π* transition energy for a large set of organic compounds. Four empirical parameter values are provided for the diagonal matrix elements of the LCAO description, corresponding to atoms of carbon, nitrogen with one pz electron, nitrogen with two pz electrons, and oxygen. The bond-length dependent formula of Harrison (proportional to 1/d2) is used for the non-diagonal matrix elements between neighbouring atoms. The predictions of our calculations have been tested against available experimental results in more than sixty organic molecules, including benzene and its derivatives, polyacenes, aromatic hydrocarbons of various geometries, polyenes, ketones, aldehydes, azabenzenes, nucleic acid bases and others. The comparison is rather successful, taking into account the small number of parameters and the simplicity of the LCAO method, involving only pz atomic-like orbitals, which leads even to analytical calculations in some cases.

Η λέξη ‘άριστος’ είναι μία από τις αρχαιότερες ελληνικές λέξεις. Η γέννηση του όρου ανάγεται σε εποχές προομηρικές, ενώ η σημερινή σημασία της λέξης διατηρεί σε αμείωτο επίπεδο την αίγλη της. Στην ομηρική σκέψη ο «άριστος» συνιστά μια αξία, ένα μέγεθος ηθικό, και μάλιστα τον ύψιστο βαθμό ανωτερότητας, καθώς αποτελεί την υπερθετική εξέλιξη του «αγαθός». Ο άριστος δεν αποτελεί έναν εκ των πολλών, αλλά τον άνδρα ο οποίος επιτυγχάνει έναν άθλο, δηλαδή τον καλύτερο όλων, τον αξιότερο. Στο ηρωϊκό έπος της Ιλιάδας, όπου κατεξοχήν συγκρούονται αντίπαλοι ήρωες, η πολεμική αναμέτρηση συνιστά την αφορμή για την ανάδειξη της «αριστείας», δηλαδή των ανδραγαθημάτων, των σημαντικότερων ηρώων του στρατοπέδου των Αχαιών, καθώς επίσης και των επιλέκτων ανδρών εκ των Τρώων. Η ομηρική αριστεία δεν περιορίζεται, ωστόσο, μόνο στο πεδίο της μάχης αλλά εκδηλώνεται και στους αθλητικούς αγώνες, όπου είναι έκδηλη η λαχτάρα της νίκης και της υπεροχής. Τόσο στην Ιλιάδα, όσο και στην Οδύσσεια το ‘νικάν’ στους αγώνες συνδέεται με το ‘αριστεύειν’, καθώς ο νικητής είναι ο άριστος, ο ικανότερος, ο πιο γενναίος όλων, εξ ου και ‘αριστεία’ ή ‘άθλα’ τα κατορθώματα του ήρωα-αθλητή. Και στα δύο έπη είναι σημαντική η ανάδειξη της αριστείας, καθώς με τον τρόπο αυτόν αποκαλύπτει ο άνδρας της ομηρικής περιόδου τον χαρακτήρα και τη δύναμή του, που απηχούν την αρετή του, γεγονός που επηρεάζει την κοινωνική του αξιολόγηση. Η ‘αριστεία’ στον Όμηρο, έχει εν τέλει χαρακτήρα επικό, σχεδόν δραματικό, καθώς ο μαχητής, προκειμένου να κατακτήσει το ιδεώδες της ανδρείας, φτάνει ως τα όρια του θανάτου, ενώ η αριστεία στον αθλητικό χώρο δεν συνιστά, παρά μία προέκταση της πολεμικής αριστείας.        

Ce travail, élaboré dans le cadre d’une recherche amorcée en 2004 et financée à partir de 2008 par le programme de recherche universitaire « Kapodistrias », est composé d’une Introduction, de trois parties divisées chacune en sept chapitres, d’un Épilogue et de deux Annexes.Dans l’Introduction (p. 17-21) est délimité le champ de réflexion, sont définis les principaux axes et fixées les limites chronologiques de l’étude. Plus précisément ce travail se donne pour propos d’étudier, dans une perspective historique, l’adaptation du système de la langue aux exigences qu’a fait surgir l’entrée progressive des femmes dans la sphère publique et notamment dans la vie professionnelle et politique. Point de départ de la réflexion, la thèse selon laquelle la langue constitue un vecteur privilégié de débats et de conflits idéologiques. Véhicule de stéréotypes et de préjugés sociaux, elle dévoile la naturelle culturelle et institutionnelle des rapports de pouvoirs inégalitaires entre les sexes ; de ce fait, elle joue un rôle actif dans le processus de construction identitaire, de formation également de la conscience de genre. La perspective chronologique commande la structure de la présente étude. Chacune de ses trois parties est centrée autour d’un temps fort de l’histoire en question.Première partie : « La naissance de la question : de la Révolution française à la IIIe République » (p. 23-61). En prenant comme point de départ de l’analyse la Révolution française, cette partie qui se divise en trois chapitres, s’étend jusqu’au milieu de la IIIe République. Chapitre I : « La Révolution française et les droits de la femme » (p. 25-31). Dans un premier temps, l’intérêt se porte ici principalement sur Olympe de Gouges. Par son action et surtout par son texte subversif de 1791, la « Déclaration des droits de la femme et de la citoyenne », cette dernière met en évidence le piège du masculin universel et conteste l’oecuménisme de la Déclaration de 1789. Ensuite, l’analyse s’intéresse à la théorie sociale de Charles Fourier. Celui-ci, conscient du rapport étroit entre égalité sociale et politique des sexes, d’une part, et visibilité du féminin au niveau linguistique, d’autre part, prend soin de créer des noms féminins pour toutes les fonctions et professions exercées au sein de la nouvelle société qu’il préconise. Chapitre II : « L’éveil de la conscience féminine collective : 1830-1848 » (p. 32-44). La période de la Monarchie de Juillet, marquée par l’action des saint-simoniennes et de Flora Tristan constitue également un moment important de cette histoire. Flora Tristan, en particulier, convaincue que l’émancipation de son sexe est intrinsèquement liée à sa visibilité dans la langue, utilise, en pleine conscience, dans ses textes les deux genres grammaticaux. Elle considère qu’en nommant les femmes, elle contribue à l’évolution des mentalités et au progrès de la société et de ses lois. L’année 1848 constitue un autre moment clé dans l’évolution de la question. L’institution, sous la IIe République, d’un « suffrage universel » excluant pourtant les femmes constitue le catalyseur qui provoque la rixe avec le socialisme et le mouvement ouvrier. Les saint-simoniennes, dont Jeanne Deroin, impliquées activement dans le débat ouvert recourent constamment à l’arsenal linguistique légué par leurs devancières. Chapitre III : « Préoccupations féministes et questions linguistiques à la fin du XIXe siècle » (p. 45-61). Ce chapitre divisé en trois unités examine le tournant survenu aux débuts de la IIIe République : c’est le moment où des liens entre féminisation des emplois et féminisation des noms se tissent. Des féministes de la première vague (Maria Deraismes, Marie-Louise Gagneur, Hubertine Auclert) associent explicitement l’égalité professionnelle et politique à la féminisation des noms de métiers et de fonctions. Elles développent les arguments de leurs devancières pour démanteler la théorie du « masculin universel » : elles soulignent la dimension sociale de la grammaire et contestent ouvertement les prises de position avancées par les membres de l’Académie française et par certains journalistes. Pour elles, l’inégalité dans la langue s’inscrit dans la culture et les institutions d’un pays. Deuxième partie : « L’évolution de la question au XXe siècle » (p. 63-102). Au cours de cette période, la féminisation de la langue cesse de constituer une affaire de penseurs sociaux et devient objet d’étude de la science linguistique nouvellement fondée. Elle préoccupe d’abord les grammairiens, puis, après 1975, les linguistes féministes. Cette partie est composée de deux chapitres. Chapitre IV : « Les grammaires françaises » (p. 65-80). Ce chapitre, divisé en deux unités, porte sur un certain nombre d’essais de grammaire publiés surtout au XXe siècle. En fonction de la prise de position de leurs auteurs, deux sont les tendances principales qui se dessinent. La première unité examine, entre autres, les essais de Cyprien Ayer (1876), d’Arsène Darmsteter (1925-1926), Maurice Grevisse (1939) qui, en invoquant l’impératif du « bon usage », soit proposent la stricte utilisation du genre masculin même pour les métiers exercées par des femmes soit se limitent à inventorier les différentes formes du féminin. De ces classifications résulte une multitude d’exceptions. La deuxième unité fait état des thèses des représentants progressistes des sciences du langage (Edouard Pichon et Jacques Damourette – 1911-1927-, Ferdiand Brunot – 1909 - et Albert Dauzat - 1954) qui en tenant compte des acquis sociaux et professionnels des femmes, proposent des féminins pour rendre ces dernières visibles dans la langue. Ces spécialistes signalent surtout le rôle de frein pour la féminisation de la langue que jouent des facteurs d’ordre psychologique : notamment le désir de certaines femmes de s’identifier sur le plan de la langue au sexe masculin, ce qui automatiquement occulte leurs conquêtes professionnelles et sociales – si elle ne les remet pas en cause. Chapitre V I « La contestation du principe de la prééminence du genre masculin » (p. 81-102). Ce chapitre tente de mettre en relief le rôle important joué par les linguistes féministes dans la promotion de la parité linguistique. Leurs travaux, qui commencent à être publiés à la fin des années 1970, décennie féministe par excellence, portent surtout sur la question de la disparition du sexe féminin derrière le genre grammatical masculin, sur la dissymétrie également des règles grammaticales quant à l’accord en genre. L’analyse insiste sur les théories de trois linguistes : Marina Yaguello, Anne-Marie Houdebine-Gravaud et Edwige Kaznadhar. Celles-ci avancent l’argument que la langue est un « miroir culturel qui fixe les représentations symboliques et se fait l’écho des préjugés et des stéréotypes » ; elles soulignent ainsi la dimension sociale de la question, d’où l’importance de l’instruction et notamment de l’enseignement de la grammaire dans la construction d’identités de genre. À l’exception de Marina Yaguello, qui sur certains points adopte des positions plus conservatrices, elles mettent en cause la théorie du masculin générique et procèdent à la déstructuration de l’image sexiste du monde : elles soulignent que l’être humain n’est pas neutre, mais a un sexe, masculin ou féminin, ce qui oblige à utiliser le genre grammatical correspondant. Vu la souplesse de la langue française, elles considèrent que celle-ci peut exprimer, sans difficultés, le nouvel ordre social et politique.La troisième partie, « Vers une politique de la parité linguistique » (p. 103-149), rend compte de l’intervention des pouvoirs publics en matière de féminisation linguistique au cours des dernières décennies du XXe siècle et examine le degré d’efficacité des politiques élaborées en la matière. Cette partie est composée de deux chapitres.Le chapitre VI, « Politiques linguistiques en France et dans d’autres pays de la francophonie (p. 105-129) comprend deux unités thématiques. La première porte sur la planification et la mise en oeuvre d’une réforme linguistique en France. On y distingue deux phases. Au milieu des années 1980, est créée, à l’instigation d’Yvette Roudy, une commission de terminologie chargée, sous la présidence de l’écrivaine Benoîte Groult, de former ou de remettre en usage les féminins de noms de métier, fonction ou titres ; cette initiative s’inscrit dans le dispositif en faveur de l’égalité professionnelle : la féminisation est ainsi présentée comme un outil contre le sexisme. Elle déclenche une vive controverse entre partisans de la réforme et Académie française soutenue par une large partie de la presse. Les travaux de la commission aboutissent à la circulaire de 1986 qui ne fut pas pourtant appliquée. La valeur symbolique du texte n’en est pas moins grande. Il a fallu que la dynamique paritaire progresse pour que la réforme prenne corps, une décennie plus tard, avec la publication d’une nouvelle circulaire en 1998 : cette évolution est surtout le résultat de la pression exercée par des femmes, membres du gouvernement Jospin. La deuxième unité du présent chapitre porte sur les interinfluences entre la France et les autres régions de la francophonie concernant la question de la féminisation de la langue. La recherche effectuée montra, enfin, que la circulaire de 1986 constitua le point de référence des initiatives entreprises dans cette direction par l’Union européenne et l’Unesco. Le chapitre VII, « Bilan d’une réforme linguistique » (p. 130-149), examine les résultats de ces politiques dans le domaine de l’administration, des médias, de la lexicographie, de l’éducation. À l’exception des manuels scolaires, l’enquête enregistra des progrès importants. Plus précisément, les documents administratifs (émanant des ministères, du Parlement, du Sénat plus récemment) appliquent de manière de plus en plus systématique les règles de la syntaxe épicène et de la féminisation des noms de grade et de fonction. En ce qui concerne le domaine des médias, la langue journalistique a fini par consacrer l’emploi des substantifs féminins en cause. La lexicographie, enfin, après une phase d’hésitation lisible dans la multitude des usages proposés, passe à une autre où est bien évidente la volonté d’enregistrer, de manière claire qui ne soulève pas de doutes, des formes grammaticales qui rendent visibles les femmes dans la langue.Dans la Conclusion (p. 151-154), est tenté un bilan du long cheminement des Françaises vers la parité linguistique qui montre l’épaisseur historique de la question. Celui-ci rappelle le rôle qu’ont joué ces pionnières et pionniers – plus rares, il est vrai – dans la contestation du masculin « universel ». Leur action a mis en évidence le rapport entre la parité linguistique et politique. Même si certains noms de métier et de fonction n’ont pas encore été dotés d’une forme féminine attestée, lacune qui perpétue une image masculine du monde, le processus de visibilité des deux sexes dans la langue – « revendication fondamentale, essentielle et existentielle » - semble être désormais irréversible.Deux annexes qui éclairent certains aspects importants de la question complètent cette étude. Dans la première (p. 157-176) sont présentés trois tables de substantifs provenant des éditions successives de trois dictionnaires français (Le Petit Robert, Le Petit Larousse, le Dictionnaire de l’Académie française) et d’un dictionnaire franco-hellénique (éd. Kauffmann). Ils mettent en lumière les progrès effectués dans le domaine de la féminisation de la langue. La deuxième annexe (p. 177-195) présente un florilège de textes traduits en grec par les auteures de la présente étude : a) articles publiés dans la presse de la fin du XIXe siècle : ils restituent le débat public ouvert entre partisanes de la féminisation de la langue et tenants du statu quo linguistique ; b) l’adresse de l’Académie française au Président de la République française publiée dans Le Figaro du 9 janvier 1998 sous le titre : « L’Académie française veut laisser les ministres au masculin » ; c) enfin les textes législatifs : les circulaires de Laurent Fabius (1986) et de Lionel Jospin (1998), la Recommandation du Comité des ministres du Conseil de l’Europe « sur l’élimination du sexisme dans le langage » : ce texte recommande aux gouvernements des États-membres de prendre des mesures en faveur de l’utilisation d’un langage reflétant le principe de l’égalité des deux sexes non seulement dans les textes juridiques et administratifs mais aussi dans l’éducation.L’étude se termine par un Index des noms de personnes (p. 221-223) et une bibliographie (p. 197-220) composée d'essais de grammaire, de dictionnaires, de guides de féminisation et de rédaction non sexiste, de manuels scolaires, d'essais philosophiques, d'articles de presse, de textes législatifs et administratifs. La diversité des sources recueillies met en relief la complexité d’une question qui est loin de n’être que linguistique pour revêtir un caractère surtout politique, social et culturel.

Port-a-cath systems are often essential for the administration of long-term chemotherapy in the treatment of malignancies because they improve venous access, but they are associated with complications, mainly thrombosis of central veins. In the present report, we describe a case of right subclavian and superior vena cava port-a-cath-related thrombosis causing superior vena cava syndrome (SVCS) in a patient affected by Hodgkin's disease. The patient underwent percutaneous revascularization with stent positioning, experiencing immediate relief of symptoms. Endovascular procedures for the treatment of nonmalignant SVCS seem to represent a challenging therapeutic option. © 2008 Am Soc Emergency Radiol.

We study the effect of a red shift and a considerable enhancement of photoluminescence (PL) intensity from a freshly etched porous Si (PS) thin film after prolonged laser irradiation or after aging in atmosphere. Both effects coincide with the appearance of Si-OH and Si-O-Si vibration modes in the Fourier transform infrared (FTIR) absorption spectra. The red shift is attributed to a pinning of the band gap of the light-emitting Si nanocrystals (NCs) due to the formation of Si-OH and Si-O-Si bonds. Using theoretical calculations, we estimated the electron and hole energy shifts caused by the interaction of the electronic states of the Si NCs with the surface vibrations, and correlated the observed PL enhancement with resonant coupling between the quantized valence sub-levels in the Si NCs and surface vibration modes. © 2008 Elsevier B.V. All rights reserved.

Background: The aim of this retrospective study was to present the epidemiological, pathological and clinical characteristics and treatment results of Greek women with epithelial ovarian cancer (EOC). Patients and Methods: From February 1976 to December 2006, 1,791 patients had been diagnosed, treated and followed up in the participating centers of the Hellenic Cooperative Oncology Group (HeCOG). Cox-regression analysis was carried out in order to identify possible prognostic factors. Results: The median age at diagnosis was 60 years. Seventy-five percent had a performance status (PS) of 0-1, 58.5% had a serous carcinoma, 36% had poorly differentiated tumors and 57% had International Federation of Gynecology and Obstetrics (FIGO) stage III disease. Approximately half of the patients had been subjected to a total abdominal hysterectomy, bilateral oophorectomy and omentectomy, and 80% of them had undergone optimal debulking surgery. Among 1,462 patients with advanced disease, 96% had received platinum-based chemotherapy, while platinum plus paclitaxel had been administered to two-thirds of them. Among 609 patients with known data for response, 34% had achieved a complete objective response (CR) and 30% a partial response (PR), resulting in an overall response rate (RR) of 64%. Performance status, FIGO stage and residual disease (RD) after cytoreductive surgery were the strongest prognostic factors for time-to-tumor progression (TTP) and for overall survival (OS), while age was found to be significant only for OS. The median TTP was 107 months (95% confidence interval (CI), 92-121 months) for patients with stages I-II, 17 months (95% CI, 15-18 months) for those with stages III-IV, 96 months (95% CI, 58-133 months) for patients without RD and 17 months (95% CI, 15-18 months) for those with RD. Median OS had not been reached for the patients with stages I-II, while it was 40 months (95% CI, 37-43 months) for those with stages III-IV, 141 months (95% CI, 103-179 months) for patients without RD and 42 months (95% CI, 39-45 months) for those with RD. Conclusion: There were no significant differences in patient characteristics or types of treatments administered in Greek women with EOC in comparison with those reported in the English literature.

In 1997, the European Communities Confederation of Clinical Chemistry and Laboratory Medicine (EC4) set up a Register for European Specialists in Clinical Chemistry and Laboratory Medicine. The operation of the Register is undertaken by a Register Commission (EC4RC). During the last 10 years, more than 2000 specialists in Clinical Chemistry and Laboratory Medicine have joined the Register. In 2007, EC4 merged with the Federation of European Societies of Clinical Chemistry and Laboratory Medicine (FESCC) to form the European Federation of Clinical Chemistry and Laboratory Medicine (EFCC). A Code of Conduct was adopted in 2003 and a revised and updated version, taking account particularly of the guidelines of the Conseil Européen des Professions Libérales (CEPLIS) of which EFCC is a member, is presented in this article. The revised version was approved by the EC4 Register Commission and by the EFCC Executive Board in Paris on 6 November, 2008. © 2009 by Walter de Gruyter Berlin New York.

Evaluation and treatment of pain following hip resurfacing arthroplasty can be challenging, even for the most experienced arthroplasty surgeon. As in any total hip replacement, there are a number of investigative tools at the disposal of orthopaedic surgeons to elicit the underlying causes of pain for diagnosis and treatment. A detailed history and physical examination are the most important first steps in the differential diagnosis of the intrinsic and extrinsic etiologies of hip pain. Serial radiographs from the time of surgery also should be reviewed and compared for changes indicative of loosening, migration, and osteolysis, in combination or alone. Diagnostic injections with local anesthetic agents additionally can be performed to localize the origin of pain. Bone scintigraphy, hip joint aspiration, and laboratory tests, including erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), should be requested routinely to exclude an occult infection. The use of ultrasound (US), magnetic resonance imaging (MRI), and even hip arthroscopy has been suggested as potential diagnostic tools when metal sensitivity is suspected. Relative to cause, femoral neck fractures and the possibility of metal hypersensitivity as sources of persistent groin pain should always be considered in metal-on-metal hip resurfacing. Additionally, iliopsoas tendinopathy and anterior impingement of the femoral neck are well-recognized causes of pain and should be included in the differential diagnosis. Surface arthroplasty is becoming an acceptable alternative to standard total hip replacement in young patients. It is increasingly essential to recognize the different causes of pain following resurfacing in order to make an accurate diagnosis and initiate timely, appropriate treatment.

An apparently unambiguous combination coccosphere from the Eastern Mediterranean (Aegean Sea, Greece) is documented involving Syracosphaera protrudens Okada & McIntyre,  1977 and Syracosphaera pulchra Lohmann, 1902 HOL pirus-type. This finding is difficult to interpret in terms of the current understanding of Syracosphaera taxonomy and adds evidence to the hypothesis of a distinctly complex Syracosphaera pulchra life cycle.

The steroid hormone-regulated gene KLK4 (kallikrein 4) is a new member of the human kallikrein-related peptidase gene family. Up to date, studies report that KLK4 is differentially expressed in many tumours. The purpose of this study was the expression analysis and study of KLK4 in benign and malignant breast tumours. Total RNA was isolated from 16 benign and 45 malignant breast tissue specimens. After testing RNA quality, cDNA was prepared by reverse transcription. Highly sensitive quantitative real-time PCR method for KLK4 mRNA quantification was developed using the SYBR Green chemistry. GAPDH served as a housekeeping gene. Relative quantification analysis was performed using the comparative C(T) method 2(-DeltaDeltaC)(T) KLK4 expression was found to vary in both patients' cohorts; however, a statistically significant elevation of the KLK4 mRNA levels was observed in malignant compared to benign tumour patients. Low KLK4 expression levels were found in well-differentiated tumours (p = 0.011) as well as in stage I (p = 0.024) patients. Moreover, a statistically significant (r(s) = -0.318, p = 0.035) negative correlation between the KLK4 expression and progesterone receptor staining was observed. ROC and logistic regression analysis recommended that KLK4 gene expression may be used as a new potential biomarker in breast cancer.

Kallikrein-related peptidases, a subgroup of the serine protease enzyme family, are considered to be important prognostic biomarkers in cancer. In this study we sought to determine the prognostic value of kallikrein-related peptidase 8 (KLK8,hK8,KLK-8) in ovarian cancer using a novel method of compartmentalised in situ protein analysis.A tissue array composed of 150 advanced stage ovarian cancers, uniformly treated with surgical debulking followed by platinum-paclitaxel combination chemotherapy,was constructed. For the evaluation of kallikrein-related peptidase 8 protein expression, we used an immunofluorescence-based method of automated in situ quantitative protein analysis (AQUA). Mean follow-up time of the cohort was 34.35 months. One hundred twenty-six of 150 cases had sufficient tissue for AQUA analysis.There were significant correlations between tumour mask KLK8 protein expression levels and clinicopathological variables, including grade (p=0.0011), residual disease (p=0.0063) and clinical response to chemotherapy(p=0.0346). In univariate survival analysis there was a significant correlation between KLK8 tumour mask expression and five years progression-free survival, meanwhile it was not associated with five-year overall survival (p =0.0694). Specifically, low KLK8 expression correlated with better outcome (top vs. bottom quartile, p=0.0319). In multivariate survival analysis, adjusting for well-characterised prognostic variables, tumour KLK8 expression level retained its prognostic significance for progression-free survival (95%Cl: 0.341-1.027, p=0.045). The possibility that KLK8 may be a suitable candidate as a diagnostic and prognostic marker warrants further investigation. © 2009 Schattauer GmbH.

Different insulin-like growth factor-1 (IGF-1) isoforms, namely IGF-1Ea, IGF-1Eb and IGF-1Ec (MGF), have been proposed to have various functions in muscle repair and growth. To gain insight into the potentially differential actions of IGF-1 isoforms in the regulation of muscle regeneration, we assessed the time course of their expressions at both mRNA and protein levels after exercise-induced muscle damage in humans. In addition, we characterized mature IGF-1 and synthetic MGF E peptide signalling in C2C12 myoblast-like cells in vitro. Ten healthy male volunteers were subjected to exercise-induced muscle damage and biopsy samples were taken from the exercised muscles before and 6 h, 2, 5 and 16 days post exercise. Muscle damage was documented by specific functional and biochemical responses post exercise. PCR-based analyses of muscle biopsy samples revealed a rapid and transient up-regulation of MGF mRNA expression which was followed by a prolonged increase of IGF-1Ea and IGF-1Eb mRNA expression (p<0.05). Patterns similar to those for mRNA expression were detected for MGF and IGF-1Ea expression at the protein level. The action of synthetic MGF E peptide differed from that of mature IGF-1 since its proliferative effect on C2C12 myoblast-like cells was not blocked by an anti-IGF-1 receptor neutralizing antibody and it did not phosphorylate Akt. Therefore, we conclude that the differential expression profile of IGF-1 isoforms in vivo and the possible IGF-1R - independent MGF E peptide signalling in skeletal muscle-like cells in vitro support the notion that tissue-specific mRNA expression of MGF isoform produces mature IGF-1 and MGF E peptides which possibly act as distinct mitogens in skeletal muscle regeneration.

Different insulin-like growth factor-1 (IGF-1) isoforms, namely IGF-1Ea, IGF-1Eb and IGF-1Ec (MGF), have been proposed to have various functions in muscle repair and growth. To gain insight into the potentially differential actions of IGF-1 isoforms in the regulation of muscle regeneration, we assessed the time course of their expressions at both mRNA and protein levels after exercise-induced muscle damage in humans. In addition, we characterized mature IGF-1 and synthetic MGF E peptide signalling in C2C12 myoblast-like cells in vitro. Ten healthy male volunteers were subjected to exercise-induced muscle damage and biopsy samples were taken from the exercised muscles before and 6 h, 2, 5 and 16 days post exercise. Muscle damage was documented by specific functional and biochemical responses post exercise. PCR-based analyses of muscle biopsy samples revealed a rapid and transient up-regulation of MGF mRNA expression which was followed by a prolonged increase of IGF-1Ea and IGF-1Eb mRNA expression (p<0.05). Patterns similar to those for mRNA expression were detected for MGF and IGF-1Ea expression at the protein level. The action of synthetic MGF E peptide differed from that of mature IGF-1 since its proliferative effect on C2C12 myoblast-like cells was not blocked by an anti-IGF-1 receptor neutralizing antibody and it did not phosphorylate Akt. Therefore, we conclude that the differential expression profile of IGF-1 isoforms in vivo and the possible IGF-1R - independent MGF E peptide signalling in skeletal muscle-like cells in vitro support the notion that tissue-specific mRNA expression of MGF isoform produces mature IGF-1 and MGF E peptides which possibly act as distinct mitogens in skeletal muscle regeneration.

Different insulin-like growth factor-1 (IGF-1) isoforms, namely IGF-1Ea, IGF-1Eb and IGF-1Ec (MGF), have been proposed to have various functions in muscle repair and growth. To gain insight into the potentially differential actions of IGF-1 isoforms in the regulation of muscle regeneration, we assessed the time course of their expressions at both mRNA and protein levels after exercise-induced muscle damage in humans. In addition, we characterized mature IGF-1 and synthetic MGF E peptide signalling in C2C12 myoblast-like cells in vitro. Ten healthy male volunteers were subjected to exercise-induced muscle damage and biopsy samples were taken from the exercised muscles before and 6 h, 2, 5 and 16 days post exercise. Muscle damage was documented by specific functional and biochemical responses post exercise. PCR-based analyses of muscle biopsy samples revealed a rapid and transient up-regulation of MGF mRNA expression which was followed by a prolonged increase of IGF-1Ea and IGF-1Eb mRNA expression (p<0.05). Patterns similar to those for mRNA expression were detected for MGF and IGF-1Ea expression at the protein level. The action of synthetic MGF E peptide differed from that of mature IGF-1 since its proliferative effect on C2C12 myoblast-like cells was not blocked by an anti-IGF-1 receptor neutralizing antibody and it did not phosphorylate Akt. Therefore, we conclude that the differential expression profile of IGF-1 isoforms in vivo and the possible IGF-1R - independent MGF E peptide signalling in skeletal muscle-like cells in vitro support the notion that tissue-specific mRNA expression of MGF isoform produces mature IGF-1 and MGF E peptides which possibly act as distinct mitogens in skeletal muscle regeneration.

EXPRESSIONS OF SKILL EFFECTIVENESS THAT ARE MORE CONGRUENT WITH TEAM PERFORMANCE IN VOLLEYBALL.Kountouris. P., Laios. Y., Drikos. S., Laios. A. Faculty of Physical Education and Sport Science, University of Athens The identification and quantification of the most consequential factors in reflecting the overall team’s performance is of primary importance in every team sport. In Volleyball it is obvious that these factors should be sought within those skills that lead to either winning or losing the specific rally. The aim of the present study was to determine whether latent derivative parameters, computed from relative proportions of decisive actions that lead immediately to winning or losing the rally, can be better predictors of team’s performance in Volleyball. Data were collected over eight seasons (2000-2008) of the Greek Men’s Volleyball Championships. For each season the overall statistics for each of the twelve teams were calculated. The original independent variables were proportions of actions that immediately led to winning or losing the rally to the total number of these actions: serve aces, serve errors, kill attacks and attack errors. From these two new variables were derived: the serve efficiency ratio (SER), which is the ratio of serve errors to serve aces, and the attack efficiency ratio (AER) which is the difference between the proportion of kill attacks and attack errors. The primary dependent variable is the set ratio (SR), which is the number of sets won divided by the total number of set played by the team. Pearson’s correlation coefficients were calculated between the dependent and the independent variables. The teams were also divided into two groups: teams with SR≤0.5 and teams with SR>0.5 and the derived variables were tested with Student’s t-test. SR does not correlate with the proportion of lost serves (r=0.037), but correlates well with the proportion of serve aces (r=0.589) and even better with SER (r=-0.661). Also the correlation coefficient between the proportions of serves errors and serve aces is quite high (r=0.530). The mean value of SER for teams with SR>0.5 is 2.3±0.5, while for teams with SR≤0.5 it is 3.0±0.6 (t-test, p<0.01). SR has a significant negative correlation with the proportion of lost attacks (r=-0.694) and an even higher positive correlation coefficient with the proportion of attack kills (r=0.819). Again SR correlates best with AER (r=0.851). The mean value of AER for teams with SR≤0.5 is 29.4%±3.7%, while for teams with SR>0.5 it is 36.1%±4.6 (t-test, p<0.01). The fact that the proportion of serve errors correlates highly with the proportion of serve aces can be founded on the nearly universal trend in modern Volleyball towards jump serves. These serves certainly have higher prospects to win a serve ace, or at least to encumber the opposing team’s reception. At the same time they undoubtedly entail a higher risk of execution. Teams that did not perform well managed on the average only one serve ace per three serve errors and their AER was less than 30%, while the for the teams that performed better the SER was nearer to two and the AER was more than 35%. Therefore the overall team’s performance in Volleyball can be better predicted by quantifiable combinations of its actions with both positive and negative outcome.  

The available analytical MHD models for jets, characterized by the symmetries of radial self-similarity (ADO, Analytical Disk Outflow solutions) in general have two geometrical shortcomings, a singularity at the jet axis and the non-existence of an intrinsic scale, i.e., the jets formally extend to radial infinity. The present study focuses on imposing an outer ejecting radius of the underlying accreting disk and thus providing a finite width disk-wind. The simulations are carried out using the PLUTO code. We study the time evolution of these modified analytical models and we investigate the rich parameter space and compare the results directly with observations.

The available analytical MHD models for jets, characterized by the symmetries of radial self-similarity (ADO, Analytical Disk Outflow solutions) in general have two geometrical shortcomings, a singularity at the jet axis and the non-existence of an intrinsic scale, i.e., the jets formally extend to radial infinity. The present study focuses on imposing an outer ejecting radius of the underlying accreting disk and thus providing a finite width disk-wind. The simulations are carried out using the PLUTO code. We study the time evolution of these modified analytical models and we investigate the rich parameter space and compare the results directly with observations.

BACKGROUND: Extrapyramidal signs (EPSs) are commonly accepted as a feature of Alzheimer disease (AD) and may influence both the profile of impairment and prognosis. OBJECTIVE: To examine rates of occurrence and risk factors for all types of EPSs and to describe the impact of EPSs over time on the clinical course of AD. DESIGN: Longitudinal study. SETTING: The Washington Heights Hamilton Heights Inwood Columbia Aging Project. Patients A total of 388 patients with incident AD (mean age, 79 years; 71.4% female). MAIN OUTCOME MEASURES: Extrapyramidal signs rated by means of a standardized portion of the Unified Parkinson's Disease Rating Scale; prevalence and incidence rates and cumulative risk for non-drug-induced EPSs; and rates of change in EPSs over time, taking into account potential covariates. RESULTS: Extrapyramidal signs were detected in 12.3% of patients at first evaluation and 22.6% at last evaluation. In a multivariate-adjusted generalized estimating equation model of change, total EPS score increased at an annual rate of 1.3%. Women (relative risk [RR], 1.57; P = .03), older patients (RR, 1.03; P = .02), and those with EPSs at baseline (RR, 2.07; P = .001) had greater rates of cognitive decline. CONCLUSIONS: Extrapyramidal signs occur frequently and progress significantly in AD. Patients with incident AD and concomitant EPSs have a greater rate of cognitive decline than do patients with incident AD but without EPSs.

We investigated whether patients who underwent internal fixation for an isolated acetabular fracture were able to return to their previous sporting activities. We studied 52 consecutive patients with an isolated acetabular fracture who were operated on between January 2001 and December 2002. Their demographic details, fracture type, rehabilitation regime, outcome and complications were documented prospectively as was their level and frequency of participation in sport both before and after surgery. Quality of life was measured using the EuroQol-5D health outcome tool (EQ-5D). There was a significant reduction in level of activity, frequency of participation in sport (both p < 0.001) and EQ-5D scores in patients of all age groups compared to a normal English population (p = 0.001). A total of 22 (42%) were able to return to their previous level of activities: 35 (67%) were able to take part in sport at some level. Of all the parameters analysed, the Matta radiological follow-up criteria were the single best predictor for resumption of sporting activity and frequency of participation.

Using finite-difference time-domain (FDTD) simulations we investigate the propagation of light pulses in waveguides having a core made of a negative-refractive-index metamaterial. In order to validate our model we carry out separate simulations for a variety of waveguide core thickness. The numerical results not only qualitatively confirm that light pulses travel slower in waveguides with thinner cores, but further they reveal that the effective refractive indices experienced by the propagating pulses compare favourably with exact theoretical predictions. We also examine the propagation of light pulses in waveguides with adiabatically, longitudinally varying core refractive index. The effective refractive indices extracted from these simulations confirm previous theoretical predictions while, both a slowing and an increase in the amplitude of the pulses are observed. © 2009 IOP Publishing Ltd.

Learning increases the survival of new cells that are generated in the hippocampal formation before the training experience, especially if the animal learns to associate stimuli across time [Gould E, Beylin A, Tanapat P, Reeves A, Shors TJ (1999) Nat Neurosci 2:260-265]. All relevant studies have been conducted on male rats, despite evidence for sex differences in this type of learning. In the present study, we asked whether sex differences in learning influence the survival of neurons generated in the adult hippocampus. Male and female adult rats were injected with one dose of bromodeoxyuridine (BrdU; 200 mg/kg), to label one population of dividing cells. One week later, half of the animals were trained with a temporal learning task of trace eyeblink conditioning, while the other half were not trained. Animals were killed 1 day after training (12 days after the BrdU injection). Hippocampal tissue was stained for BrdU and a marker of immature neurons, doublecortin. Both sexes learned to emit the conditioned eyeblink response during the trace interval. As a consequence, more new neurons remained in their hippocampi than in sex-matched controls. In individual animals, the number of surviving cells correlated positively with asymptotic performance; those that expressed more learned responses retained more new neurons. However, animals that learned very well retained even more new cells if they required many trials to do so. Because females emitted more learned responses than males did, they retained nearly twice as many new cells per unit volume of tissue. This effect was most evident in the ventral region of the hippocampal formation. Thus, sex differences in learning alter the anatomical structure of the hippocampus. As a result, male and female brains continue to differentiate in adulthood.

In order to single out dominant phenomena that account for carrier-controlled magnetism in p-Cd1-xMnxTe quantum wells we have carried out magneto-optical measurements and Monte Carlo simulations of time-dependent magnetization. The experimental results show that magnetization relaxation is faster than 20 ns in the paramagnetic state. Decreasing temperature below the Curie temperature TC results in an increase of the relaxation time but to less than 10 μs. This fast relaxation may explain why the spontaneous spin splitting of electronic states is not accompanied by the presence of nonzero macroscopic magnetization below TC. Our Monte Carlo results reproduce the relative change of the relaxation time on decreasing temperature. At the same time, the numerical calculations demonstrate that antiferromagnetic spin-spin interactions, which compete with the hole-mediated long-range ferromagnetic coupling, play an important role in magnetization relaxation of the system. We find, in particular, that magnetization dynamics is largely accelerated by the presence of antiferromagnetic couplings to the Mn spins located outside the region, where the holes reside. This suggests that macroscopic spontaneous magnetization should be observable if the thickness of the layer containing localized spins will be smaller than the extension of the hole wave function. Furthermore, we study how a spin-independent part of the Mn potential affects TC. Our findings show that the alloy disorder potential tends to reduce TC, the effect being particularly strong for the attractive potential that leads to hole localization.

The magnetic state of nitrogen-doped MgO, with N substituting O at concentrations between 1% and the concentrated limit, is calculated with density-functional methods. The N atoms are found to be spin polarized with a moment of 1 mu(B) per nitrogen atom and to interact ferromagnetically via the double-exchange mechanism in the full concentration range. The long-range magnetic order is established above a finite concentration of about 1.5% when the percolation threshold is reached. The disorder is described within the coherent-potential approximation, with the exchange interactions harvested by the method of infinitesimal rotations. The Curie temperature T-C, calculated within the random-phase approximation, increases linearly with the concentration, and is found to be about 30 K for 10% concentration. Besides the substitution of single nitrogen atoms, also interstitial nitrogen atoms, dimers and trimers, and their structural relaxations are discussed with respect to the magnetic state. Possible scenarios of engineering a higher Curie temperature are analyzed, with the conclusion that an increase in T-C is difficult to achieve, requiring a particular attention to the choice of chemistry.

This paper provides evidence of integration in European equity and bond markets over the period January 2, 1997 to October 1, 2006. Our focus is to examine time-varying correlation dynamics in Euro-area, Central European (CE) and Balkan financial markets, modifying the asymmetric generalized dynamic conditional correlation (AG-DCC) model developed by Cappiello, Engle and Sheppard (Journal of Financial Econometrics, 2006). Using structural breaks, we identify the optimal time decay where financial markets share highest comovement. The results show an increase in the level of dependence during the period of the internet bubble collapse (2000), the Balkan countries start formally discussions to join European Union (2000), the introduction of Euro banknotes and coins (2002) and the entry of CE countries in EU (2004). The CE European and Balkan countries become gradually more integrated with the EMU countries, which is consistent with the interpretation that these countries may be expected to join the Euro in the future.

Bortezomib-based regimens are beneficial in the treatment of patients with symptomatic, newly diagnosed and relapsed or refractory multiple myeloma. researchers who investigated the efficacy and safety of single-agent bortezomib as first-line therapy in patients with myeloma have particularly emphasized the incidence and management of peripheral neuropathy, which is the most common adverse effect of bortezomib administration. © 2009 Macmillan Publishers Limited. All rights reserved.

We hypothesised that the use of bioabsorbable pins in Mitchell's osteotomy would improve the outcome of patients treated for hallux valgus deformity. A total of 68 patients underwent Mitchell's osteotomy to correct hallux valgus deformity: 33 patients (group A) underwent Mitchell's osteotomy augmented with bioabsorbable pins and 35 patients were treated with the classic operative procedure (group B). Hallux valgus angle (HVA), intermetatarsal angle (IMA), the American Orthopaedic Foot and Ankle Society (AOFAS) hallux metatarsophalangeal-interphalangeal scale and the visual analogue score (VAS) for pain were measured preoperatively and postoperatively. There was no statistically significant difference between the two groups as far as the improvement of the IMA, HVA and AOFAS scale were concerned. Patients of group A had significantly less postoperative pain and returned to their previous activities earlier than patients of group B. The use of the pins did not improve the final outcome of the osteotomy. However, it allowed for faster rehabilitation due to less postoperative pain.

Karlovassi basin area has been studied for long period by the team from University of Athens. This area suffers from frequent floods which frequency even raised after large area of forests in Kerketeas Mountain area was burned down in year 2000. In recent period the area has been studied from the point of view of flood risk. High volume of data was collected and processed as an input to the flood risk model. The model was built using Arc Hydro toolset in ArcGIS environment (Maidment, 2002). Based on this model a GIS based flood risk map was created. In order to get more detail description of rainfall-runoff process a decision has been made to apply hydrologic model which works with more detail description of runoff process. For these purposes fully HEC-1 model (Hydrologic Engineering Center, 1998) was chosen. HEC-1 describes runoff process with semi-distributed approach. Results for modeling of precipitation event from November 2001 are presented here.

OBJECTIVE: Fluctuating dental asymmetry is considered a sensitive indicator of environmental stress. We used fluctuating asymmetry of teeth in Greek children to assess the effect of the Chernobyl accident to the Greek population, which received relatively large radiation exposure compared to other European countries. DESIGN: Sixty dental casts were divided into two groups according to date of birth prior to or after the Chernobyl accident. The intercuspal distances of the mandibular first permanent molars were measured with digital calipers. We followed the data analysis procedure proposed by Palmer and Strobeck (2003). RESULTS: Fluctuating asymmetry was found at levels above measurement error in all traits except for the buccal measurement. Overall, there were no significant differences in the fluctuating asymmetry between the two groups, after removal of outliers. CONCLUSIONS: These results suggest that environmental radioactivity from the Chernobyl incident did not significantly affect the symmetry of lower permanent molar intercuspal distances in the specific population, even though increased levels of radionuclides have been reported in teeth and other tissues.

The elaboration of analytical microzoning studies involves a multidisciplinary approach comprising geological, geotechnical, seismological, geophysical and dynamic soil analysis data. In an attempt to incorporate the maximum available amount of information and in the view of the continuously expanding use of GIS, as a tool for analyzing and integrating data, a new software environment called AUTO-SEISMO-GEOTECH has been developed for handling these multi-parameter data. This user friendly package is presently implemented for the cities of Heraklion (Crete island- province of Heraklion) and Thiva (province of Viotia) in Greece. The pilot methodologies applied in these urban areas, aimed also at determining a minimum package of tasks/methods needed for the elaboration of a microzoning study, are described and evaluated here. Next, a database with appropriate architecture was formed in order to handle all available geo-information for each city separately and produce thematic maps, such as geological, tectonic, hydrogeological, seismic hazard and microzonation ones. These maps can be easily reproduced, integrated and used for building safer constructions contributing so to mitigation of earthquake consequences. Geo-information obtained by a) existing regional seismicity maps and installation of local portable seismographic networks around both cities, to monitor the microseismic activity and define possible active fault zones, b) geological mapping of the broader urban area in scale 1:5000, c) evaluation of existing geotechnical data as well as new data coming from boreholes, d) geophysical data resulting from surface and borehole techniques, for Vp, Vs and dynamic elastic parameters estimation and e) consideration of historical seismological data for seismic hazard estimation, have been incorporated in this GIS based platform, to be easily handled for further use. The output of this information combined with the dynamic soil analysis produces detailed microzonation maps. Such maps are valuable for city planners and urban designers.

We explore the use of fractional order differential equations for the analysis of datasets of various drug processes that present anomalous kinetics, i.e. kinetics that are non-exponential and are typically described by power-laws. A fractional differential equation corresponds to a differential equation with a derivative of fractional order. The fractional equivalents of the ``zero-{''} and ``first-order{''} processes are derived. The fractional zero-order process is a power-law while the fractional first-order process is a Mittag-Leffler function. The latter behaves as a stretched exponential for early times and as a power-law for later times. Applications of these two basic results for drug dissolution/release and drug disposition are presented. The fractional model of dissolution is fitted successfully to datasets taken from literature of in vivo dissolution curves. Also, the proposed pharmacokinetic model is fitted to a dataset which exhibits power-law terminal phase. The Mittag-Leffler function describes well the data for small and large time scales and presents an advantage over empirical power-laws which go to infinity as time approaches zero. The proposed approach is compared conceptually with fractal kinetics, an alternative approach to describe datasets with non exponential kinetics. Fractional kinetics offers an elegant description of anomalous kinetics, with a valid scientific basis, since it has already been applied in problems of diffusion in other fields, and describes well the data.

 (2009). Goggaki, Konstantina. Assistant Professor in Philosophy of Sport, University of Athens, Greece. The fragmented nature of physical education and sport in European schools is a cause in the decline in interest of youth sport. XIII OLYMPIC CONGRESS, Contributions, International Olympic Committee, Copenhagen, pp. 634-635.  Sport is not an integral part of mainstream education in most European schools and as a result is inadequate as an education tool. Gymnastics for example, is an activity that is practically devoid of pedagogical content and is reduced to being a secondary activity that is not connected to the overall educational process. The modern school system does not have real substance and absorbs the students’ leisure time through the implementation of a static curriculum. How can this situation be changed? In what way can the Olympic family intervene in a case which seems to be the sole responsibility of governments? And how can this intervention be effective? There is much more that needs to be done in this area.

A new boron-based flexible scorpionate ligand based upon 7-azaindole, Li[Ph(H)B(azaindolyl)2] (Li[phBai]), has been prepared. This ligand, together with the previously reported ligand K[HB(azaindolyl) 3] (K[Tai]), have been used to prepare a range of monovalent group 9 transition-metal complexes. The complexes [M(COD){K3N,N,H-Ph(H) B(azaindolyl)2}] (where M = rhodium, iridium and COD = 1,5-cyclooctadiene) and [Rh(NBD){K3N,N,H-HB(R)(azaindolyl) 2}] (where NBD = 2,5-norbornadiene and R = Ph, azaindolyl) have been prepared. Structural characterization of [M(COD){K3NNH-Ph(H) B(azaindolyl)2}] (where M = rhodium, iridium) and [Rh(NBD){k 3N, N, H-HB(azaindolyl)3}] reveal strong interactions of the B-H functional group with the metal centers, particularly in the case of [Ir(COD){K3N,N,H-Ph(H)B(azaindolyl)2}]. The complex [Rh(NBD){K3N,N,H-HB(azaindolyl)3}] undergoes a further reaction, resulting from hydride migration from boron to the norbornadiene group. Subsequent rearrangement results in the formation of the rhodium-nortricyclyl complex [Rh(nortricyclyl){k4 N,N,-B,N-B(azaindolyl)3}], providing the first nitrogen-based metallaboratrane complex to contain the tetradentate (K4N,N,B,N) coordination mode. © 2009 American Chemical Society.

Skin prick testing is the standard for diagnosing IgE-mediated allergies. However, different allergen extracts and different testing procedures have been applied by European allergy centres. Thus, it has been difficult to compare results from different centres or studies across Europe. It was, therefore, crucial to standardize and harmonize procedures in allergy diagnosis and treatment within Europe.|The Global Asthma and Allergy European Network (GA(2)LEN), with partners and collaborating centres across Europe, was in a unique position to take on this task. The current study is the first approach to implement a standardized procedure for skin prick testing in allergies against inhalant allergens with a standardized pan-European allergen panel.|The study population consisted of patients who were referred to one of the 17 participating centres in 14 European countries (n = 3034, median age = 33 years). Skin prick testing and evaluation was performed with the same 18 allergens in a standardized procedure across all centres.|The study clearly shows that many allergens previously regarded as untypical for some regions in Europe have been underestimated. This could partly be related to changes in mobility of patients, vegetation or climate in Europe.|The results of this large pan-European study demonstrate for the first time sensitization patterns for different inhalant allergens in patients across Europe. The standardized skin prick test with the standardized allergen battery should be recommended for clinical use and research. Further EU-wide monitoring of sensitization patterns is urgently needed.

Skin prick testing is the standard for diagnosing IgE-mediated allergies. A positive skin prick reaction, however, does not always correlate with clinical symptoms. A large database from a Global Asthma and Allergy European Network (GA(2)LEN) study with data on clinical relevance was used to determine the clinical relevance of sensitizations against the 18 most frequent inhalant allergens in Europe. The study population consisted of patients referred to one of the 17 allergy centres in 14 European countries (n = 3034, median age = 33 years). The aim of the study was to assess the clinical relevance of positive skin prick test reactions against inhalant allergens considering the predominating type of symptoms in a pan-European population of patients presenting with suspected allergic disease.|Clinical relevance of skin prick tests was recorded with regard to patient history and optional additional tests. A putative correlation between sensitization and allergic disease was assessed using logistic regression analysis.|While an overall rate of >or=60% clinically relevant sensitizations was observed in all countries, a differential distribution of clinically relevant sensitizations was demonstrated depending on type of allergen and country where the prick test was performed. Furthermore, a significant correlation between the presence of allergic disease and the number of sensitizations was demonstrated.|This study strongly emphasizes the importance of evaluating the clinical relevance of positive skin prick tests and calls for further studies, which may, ultimately, help increase the positive predictive value of allergy testing.

The number of allergens to be tested in order to identify sensitized patients is important in order to have the most cost-effective approach in epidemiological studies.|To define the minimal number and the type of skin prick test (SPT) allergens required to identify a patient as sensitized using results of the new Pan-European GA(2)LEN skin prick test study.|In a large Pan-European multicenter (17 centers in 14 countries) patient based study, a standardized panel of 18 allergens has been prick tested using a standardized procedure. Conditional approach allowed to determine the allergens selection.|Among the 3034 patients involved, 1996 (68.2%) were sensitized to at least one allergen. Overall, eight allergens (grass pollen, Dermatophagoides pteronyssinus, birch pollen, cat dander, Artemisia, olive pollen, Blatella and Alternaria) allowed to identified more than 95% of sensitized subjects. However, differences were observed between countries, two allergens being sufficient for Switzerland (grass pollen and cat dander) as opposed to nine for France (grass pollen, Dermatophagoides pteronyssinus, olive pollen, cat dander, Blatella, cypress, dog dander, alder and [Artemisia or Alternaria]). According to country, up to 13 allergens were needed to identify all sensitized subjects.|Eight to ten allergens allowed the identification of the majority of sensitized subjects. For clinical care of individual patients, the whole battery of 18 allergens is needed to appropriately assess sensitization across Europe.

The upper Miocene of Karlovassi Basin, Samos Island, Greece, contain continental evaporites such as colemanite, ulexite, celestite, gypsum and thenardite. These evaporites are related with volcanic tuffs, diagenetically altered in a saline-alkaline lake environment. The aim of the present paper is to: a) define the impact of the already known and possible buried borates and other evaporites to the geochemistry of the hydrogeological system of Karlovassi Basin, and; b) to assess the correlation between surface and underground evaporite deposits considering the spatial changes in the concentrations of the examined physicochemical parameters. Fieldwork, laboratory measurements and literature data revealed elevated boron values (2136–33012 ⧎/L) in the central part of Karlovassi Basin. In the same area, high amounts of strontium, sodium, lithium and sulfates also occur. It is proposed that these ions originate from the leaching of evaporites and authigenic minerals such as the Sr-rich clinoptilolite and the boron-bearing potassium feldspar. Boron values are abnormally high for freshwater aquifers, and are indicative of the presence of buried evaporites in the basin with unknown significance.

INTRODUCTION: Cervical vertebrae shape has been proposed as a diagnostic factor for assessing skeletal maturation in orthodontic patients. However, evaluation of vertebral shape is mainly based on qualitative criteria. Comprehensive quantitative measurements of shape and assessments of its predictive power have not been reported. Our aims were to measure vertebral shape by using the tools of geometric morphometrics and to evaluate the correlation and predictive power of vertebral shape on skeletal maturation. METHODS: Pretreatment lateral cephalograms and corresponding hand-wrist radiographs of 98 patients (40 boys, 58 girls; ages, 8.1-17.7 years) were used. Skeletal age was estimated from the hand-wrist radiographs. The first 4 vertebrae were traced, and 187 landmarks (34 fixed and 153 sliding semilandmarks) were used. Sliding semilandmarks were adjusted to minimize bending energy against the average of the sample. Principal components analysis in shape and form spaces was used for evaluating shape patterns. Shape measures, alone and combined with centroid size and age, were assessed as predictors of skeletal maturation. RESULTS: Shape alone could not predict skeletal maturation better than chronologic age. The best prediction was achieved with the combination of form space principal components and age, giving 90% prediction intervals of approximately 200 maturation units in the girls and 300 units in the boys. Similar predictive power could be obtained by using centroid size and age. Vertebrae C2, C3, and C4 gave similar results when examined individually or combined. C1 showed lower correlations, signifying lower integration with hand-wrist maturation. CONCLUSIONS: Vertebral shape is strongly correlated to skeletal age but does not offer better predictive value than chronologic age.

Santorini is an island of the Aegean Sea that belongs to the Prefecture of Cyclades. It is located southern of Ios Island and, along with Anafi, these are the southernmost islands of the Cyclades. Santorini is composed of Thera, with a crescent shape, and the islands of Therassia and Aspro (Aspronisi) in a circle. In the centre of the circle lies the caldera, which was formed by a volcanic eruption (or eruptions) and the simultaneous collapse of a part of the island. Santorini caldera is one biggest of the world, covering an area of approx. 83 km2, with a length of 11 km (N–S) and a width of 7.5 km (E–W). The volcanic islands of Nea Kameni and Palaia Kameni have formed within the caldera. Nowadays Santorini is a volcanic island that belongs to the Aegean volcanic arc and, with its fumaroles, gases and a high temperature, is the only active volcano in the Eastern Mediterranean.

Με αφορμή την επέτειο των 120 χρόνων από τη γέννηση του αυστριακού ποιητή Georg Trakl το Τμήμα Γερμανικής Γλώσσας και Φιλολογίας του Πανεπιστημίου Αθηνών, σε συνεργασία με την αυστριακή πρεσβεία στην Αθήνα, διοργάνωσε ημερίδα για τον ποιητή (24 Νοεμβρίου 2007), με τη συμμετοχή του διευθυντή του Κέντρου Ερευνών Georg Trakl (Trakl Forschungs- und Gedenkstätte) κ. Hans Weichselbaum. Η εκδήλωση εντάχθηκε στους εορτασμούς για τα 170 χρόνια από την ίδρυση του Εθνικού και Καποδιστριακού Πανεπιστημίου Αθηνών. Από πλευράς του Τμήματος Γερμανικής Γλώσσας και Φιλολογίας την επιστημονική-οργανωτική επιτροπή αποτέλεσαν η Κατερίνα Μητραλέξη και η Εύη Πετροπούλου, οι οποίες επιμελήθηκαν στη συνέχεια την έκδοση των πρακτικών του συνεδρίου. Οι εισηγήσεις ανέδειξαν σημαντικές πτυχές του ποιητικού έργου του Georg Trakl, εισηγητή του εξπρεσιονισμού στην αυστριακή λογοτεχνία, ο οποίος συγκαταλέγεται ανάμεσα στις εμβληματικές μορφές της ευρωπαϊκής νεωτερικότητας. Ο τόμος συμπεριλαμβάνει τις έντεκα εισηγήσεις, οι οποίες ανίχνευσαν: τις καταβολές του ποιητή που εντοπίζονται στη Βιεννέζικη Πρωτοπορία (1910) και την πορεία του προς τον λογοτεχνικό μοντερνισμό (Hans Weischelbaum)· τους συσχετισμούς ανάμεσα στη λογοτεχνία και τη ζωγραφική στο πλαίσιο του καλλιτεχνικού ρεύματος του εξπρεσιονισμού (Willi Benning)· τις εικόνες εκείνες στο ποιητικό του έργο που χαρακτηρίζονται από τη διαλεκτική μιας επίκλησης του θείου μέσω της άρνησής του και ως εκ τούτου μπορούν να λειτουργήσουν αντιπροσωπευτικά για τον λανθάνοντα μυστικισμό της λογοτεχνίας της νεωτερικότητας (Stefan Lindinger)· τη σημασιολογία της μικρής, αόριστης αλλά πολυσήμαντης λέξης «ίσως» στο ποιητικό έργο διαπιστώνοντας ότι αναδεικνύεται σε μείζονα ποιητικό όρο για το λυρικό σύμπαν του ποιητή (Joachim Theisen)· την έντονη διακειμενικότητα που εμφανίζεται στο έργο του ποιητή (Εύη Πετροπούλου)· την ποιητική του Georg Trakl ως όρο για τη μετάφραση του έργου του, καταλήγοντας στη διαπίστωση ότι αναγκαία προϋπόθεση για την απόδοση του έργου είναι μια μεταφραστική εργασία ανοιχτή προς το αινιγματικό (Έλενα Νούσια)· το ρόλο του αστικού τοπίου και της υπαίθρου στην ιδιότυπα εξπρεσιονιστική ποίηση του Trakl (Γιώργος Κεντρωτής)· την αναφορά στο μύθο του Ορφέα ως ψηλάφηση των ορίων της γλώσσας και της σχέσης της με τον χρόνο και τη μνήμη, με την ταυτότητα και τον έρωτα, την παρακμή και τον θάνατο, και τις εκφάνσεις του στην ποίηση του εξπρεσιονισμού και εμφατικά στην ποίηση του Trakl (Κατερίνα Καρακάση)· τις ελληνικές μεταφράσεις της ποίησης του Trakl αντιπαραβάλλοντας τις μεταφραστικές εκδοχές τεσσάρων μεταφραστών, του Δημήτρη Δήμου, 1983, του Ανδρέα Αγγελάκη, 1984, της Έλενας Νούσια, 1990, και του Μιχάλη Παπαντωνόπουλου, 2005 (Αναστασία Δασκαρόλη)· την πρόσληψη του έργου του Georg Trakl στην Ελλάδα στο πλαίσιο της πρόσληψης του γερμανικού εξπρεσιονισμού και τις επιδράσεις στην ποίηση του Νίκου Εγγονόπουλου, του Μίλτου Σαχτούρη και της Έλενας Νούσια (Κατερίνα Μητραλέξη)· τη σχέση της ποίησης του Trakl με τη ζωγραφική του Egon Schiele με απώτερο στόχο την ανάδειξη των σημαντικότερων όψεων του αυστριακού εξπρεσιονισμού (Αναστασία Αντωνοπούλου).

Gynaecological problems are rare in childhood and adolescence but can cause signifi cant distress to affected children and their families. These children may first visit paediatric surgeons and paediatricians who may not be familiar with gynaecological ailments. It is important that paediatric surgeons are aware of these problems to ensure correct management with appropriate referral if necessary. This chapter describes common gynaecological conditions occurring in children. © 2009 Springer Berlin Heidelberg.

We construct the holonomy groupoid of any singular foliation. In the regular case this groupoid coincides with the usual holonomy groupoid of Winkelnkemper ([H. E. Winkelnkemper, The graph of a foliation, Ann. Glob. Anal. Geom. 1 (3) (1983), 51–75.]); the same holds in the singular cases of [J. Pradines, How to define the differentiable graph of a singular foliation, C. Top. Geom. Diff. Cat. XXVI(4) (1985), 339–381.], [B. Bigonnet, J. Pradines, Graphe d'un feuilletage singulier, C. R. Acad. Sci. Paris 300 (13) (1985), 439–442.], [C. Debord, Local integration of Lie algebroids, Banach Center Publ. 54 (2001), 21–33.], [C. Debord, Holonomy groupoids of singular foliations, J. Diff. Geom. 58 (2001), 467–500.], which from our point of view can be thought of as being “almost regular”. In the general case, the holonomy groupoid can be quite an ill behaved geometric object. On the other hand it often has a nice longitudinal smooth structure. Nonetheless, we use this groupoid to generalize to the singular case Connes' construction of the C*-algebra of the foliation. We also outline the construction of a longitudinal pseudo-differential calculus; the analytic index of a longitudinally elliptic operator takes place in the K-theory of our C*-algebra. In our construction, the key notion is that of a bi-submersion which plays the role of a local Lie groupoid defining the foliation. Our groupoid is the quotient of germs of these bi-submersions with respect to an appropriate equivalence relation.

This case report describes the treatment of a patient whose maxillary left first premolar was impacted horizontally, and both maxillary canines were transposed relative to the first premolars. The patient was treated without extractions, and both canines were brought to their correct positions in the maxillary arch. Treatment mechanics during the various stages are discussed.

A discrimination of the different aerosol types over the Arabian Sea (AS) during the Integrated Campaign for Aerosols, Gases and Radiation Budget (ICARB-06) is made using values of aerosol optical depth (AOD) at 500 nm (AOD500) and Ångström exponent (α) in the spectral band 340-1020 nm (α340-1020). For this purpose, appropriate thresholds for AOD500 and α340-1020 are applied. It is shown that a single aerosol type in a given location over the AS can exist only under specific conditions while the presence of mixed aerosols is the usual situation. Analysis indicates that the dominant aerosol types change significantly in the different regions (coastal, middle, and far) of AS. Thus the urban/industrial aerosols are mainly observed in coastal AS, the desert dust particles occur in the middle and northern AS, while clear maritime conditions mainly occur in far AS. Spectral AOD and Ångström exponent data were analyzed to obtain information about the adequacy of the simple use of the Ångström exponent and spectral variation of a for characterizing the aerosols. Using the least squares method, α is calculated in the spectral interval 340-1020 nm along with the coefficients a1 and a2 of the second-order polynomial fit to the plotted logarithm of AOD versus the logarithm of wavelength. The results show that the spectral curvature can effectively be used as a tool for their discrimination, since the fine mode aerosols exhibit negative curvature, while the coarse mode particles exhibit positive curvature. The correlation between the coefficients a1 and a2 with the Ångström exponent, and the atmospheric turbidity, is further investigated. Copyright 2009 by the American Geophysical Union.

A discrimination of the different aerosol types over the Arabian Sea (AS) during the Integrated Campaign for Aerosols, Gases and Radiation Budget (ICARB-06) is made using values of aerosol optical depth (AOD) at 500 nm (AOD500) and Ångström exponent (α) in the spectral band 340-1020 nm (α340-1020). For this purpose, appropriate thresholds for AOD500 and α340-1020 are applied. It is shown that a single aerosol type in a given location over the AS can exist only under specific conditions while the presence of mixed aerosols is the usual situation. Analysis indicates that the dominant aerosol types change significantly in the different regions (coastal, middle, and far) of AS. Thus the urban/industrial aerosols are mainly observed in coastal AS, the desert dust particles occur in the middle and northern AS, while clear maritime conditions mainly occur in far AS. Spectral AOD and Ångström exponent data were analyzed to obtain information about the adequacy of the simple use of the Ångström exponent and spectral variation of a for characterizing the aerosols. Using the least squares method, α is calculated in the spectral interval 340-1020 nm along with the coefficients a1 and a2 of the second-order polynomial fit to the plotted logarithm of AOD versus the logarithm of wavelength. The results show that the spectral curvature can effectively be used as a tool for their discrimination, since the fine mode aerosols exhibit negative curvature, while the coarse mode particles exhibit positive curvature. The correlation between the coefficients a1 and a2 with the Ångström exponent, and the atmospheric turbidity, is further investigated. Copyright 2009 by the American Geophysical Union.

AIM: To evaluate the impact of hepatitis B core antibody (anti-HBc) seropositivity in sustained virological response (SVR) rates in treatment-naïve, chronic hepatitis C (CHC) patients with high pretreatment viral load (>800000 IU/mL). METHODS: 185 consecutive CHC patients (14.4% cirrhotics, 70.2% prior intravenous drug users) treated with pegylated interferon-a2b plus ribavirin, for 24 or 48 weeks based on viral genotype, were retrospectively analyzed. SVR was confirmed by undetectable serum HCV-RNA six months after the end of treatment schedule. RESULTS: Thirty percent of CHC/HBsAg-negative patients were anti-HBc-positive. Anti-HBc positivity was more prevalent in cirrhotic, compared to noncirrhotic patients (76.9% versus 19.5%, P < .05). Serum HBV-DNA was detected in the minority of anti-HBc-positive patients (1.97%). Overall, 62.1% of patients exhibited SVR, while 28.6% did not; 71.4% of non-SVRs were infected with genotype 1. In the univariate analysis, the anti-HBc positivity was negatively associated with treatment outcome (P = .065). In the multivariate model, only the advanced stage of liver disease (P = .015) and genotype-1 HCV infection (P = .003), but not anti-HBc-status (P = .726), proved to be independent predictors of non-SVR. CONCLUSION: Serum anti-HBc positivity does not affect the SVR rates in treatment-naïve CHC patients with high pretreatment viral load, receiving the currently approved combination treatment.

BACKGROUND: The effect of hepatitis B virus (HBV) infection on the natural history of human immunodeficiency virus (HIV) disease remains uncertain. Therefore, a retrospective cohort study was conducted to examine the influence of HIV-HBV coinfection on AIDS development and overall mortality. Moreover, our results were added to those of previous studies in a literature-based meta-analysis. METHODS: Serum samples obtained from HIV-seropositive patients from 1984 through 2003 were retrospectively tested for hepatitis B surface antigen. Multivariable analyses were performed using Poisson and logistic regression models. For meta-analytic purposes, eligible articles were identified and relevant data were abstracted. Pooled estimates of effect were calculated applying fixed and random effects models. RESULTS: The prevalence of chronic HBV infection (documented hepatitis B surface antigen seropositivity for >6 months) among 1729 HIV-positive patients was approximately 6%. The multivariable analyses in our primary study revealed no significant impact of concomitant HIV-HBV infection on progression to AIDS and all-cause mortality. However, a meta-analysis performed on data from 12,382 patients enrolled in 11 studies revealed a significant effect of HIV-HBV coinfection on overall mortality (pooled effect estimate, 1.36; 95% confidence interval, 1.12-1.64). The increased rate of death among coinfected individuals was observed in the meta-analyses of studies conducted both before (pooled effect estimate, 1.60; 95% confidence interval, 1.07-2.39) and after (pooled effect estimate, 1.28; 95% confidence interval, 1.03-1.60) commencement of highly active antiretroviral therapy. CONCLUSIONS: HIV-HBV coinfection seems to affect all-cause mortality, and strategies to reduce liver damage in patients coinfected with HIV and HBV are justified.

OBJECTIVES: The evaluation of a service-oriented prototype implementation for healthcare interoperability. METHODS: A prototype framework was developed, aiming to exploit the use of service-oriented architecture (SOA) concepts for achieving healthcare interoperability and to move towards a virtual patient record (VPR) paradigm. The prototype implementation was evaluated for its hypothetical adoption. The evaluation strategy was based on the initial proposition of the DeLone and McLean model of information systems (IS) success [1], as modeled by Iivari [2]. A set of SOA and VPR characteristics were empirically encapsulated within the dimensions of IS success model, combined with measures from previous research works. The data gathered was analyzed using partial least squares (PLS). RESULTS: The results highlighted that system quality is a partial predictor of system use but not of user satisfaction. On the contrary, information quality proved to be a significant predictor of user satisfaction and partially a strong significant predictor of system use. Moreover, system use did not prove to be a significant predictor of individual impact whereas the bi-directional relation between use and user satisfaction did not confirm. Additionally, user satisfaction was found to be a strong significant predictor of individual impact. Finally, individual impact proved to be a strong significant predictor of organizational impact. CONCLUSIONS: The empirical study attempted to obtain hypothetical, but still useful beliefs and perceptions regarding the SOA prototype implementation. The deduced observations can form the basis for further investigation regarding the adaptability of SOA implementations with VPR characteristics in the healthcare domain.

The objective of this study is to investigate the impact of the eastern Mediterranean teleconnection pattern (EMP) on the present and future climate of the eastern Mediterranean during winter. For the present climate, daily precipitation and maximum and minimum surface temperature station data are employed for the period of 1958-2003. For the future climate, datasets of the same parameters are derived from the Hadley Centre Regional Climatic Model (HadRM3P) for the period of 2070-2100, using two Intergovernmental Panel on Climate Change (IPCC) emission scenarios for the evolvement of the future atmospheric concentrations of greenhouse gases. The investigation of the impact was based on the regularized canonical correlation analysis (RCCA), while qualitative estimations were performed for each phase of the pattern. It was found that the pattern indeed affects the mean winter patterns of temperature, precipitation, and their extreme events with inverse impacts between the two phases. More specifically, a positive phase of EMP is associated with a decrease in temperatures and an increase in precipitation, while the opposite occurs during the negative phase of EMP. In the future, the present impact according to each phase persists and intensifies in most of the cases. However, results are quite different between the two scenarios, because of the different estimated future shift of the EMP poles. © 2009 American Meteorological Society.

When the novel agents thalidomide, bortezomib and lenalidomide are administered to patients with myeloma in the context of clinical trials, they are associated with a significant improvement in response, progression-free survival and in some studies, overall survival (OS); however, their effect on the outcome of unselected myeloma patients has not been fully assessed. We compared the outcome of 1376 unselected patients with symptomatic myeloma, who started treatment before or after the introduction of thalidomide. The median OS in patients who started treatment after the introduction of novel agents increased by 12 months (48 vs 36 months, P<0.001). This improvement was more pronounced in patients ≤70 years (from 39 to 74 months, P<0.001), but less evident in patients >70 years (from 26 to 33 months, P=0.27). In patients treated after the introduction of novel agents, the international staging system (ISS) could discriminate three groups with significantly different outcomes (5-year survival for ISS stage I, II and III was 66, 45 and 18%, respectively, P<0.001). ISS was also valid in patients who actually received upfront treatment with novel drugs (4-year survival rate was 85, 61 and 26% for ISS stage I, II and III patients, P=0.001).

This articles presents a rare case of accidental insertion of an intravascular catheter into an artery by an experienced nurse (RN). Due to the patient's hypotension, this faulty positioning was misdiagnosed and a potential peripheral ischemic necrosis was, fortunately, avoided only because the anesthesia drug injection was performed through another vein. Clinical signs were also present but were also underestimated. After intra-arterial confirmation of the incorrect position, the catheter was subsequently removed. No further complications were observed.

Background: New cases of well-differentiated thyroid cancer (DTC) are diagnosed more frequently worldwide. We investigated trends and differences in clinical and histological characteristics of new DTC cases presenting in one large center. Methods: During the last 34 years 852 follicular cell-derived DTC cases (83% papillary [PTC], 17% follicular [FTC] carcinoma) presented in the Endocrine Unit of the Department of Clinical Therapeutics in Alexandra Hospital (18.8% men, mean age 42.4±14.5 years). Patients were classified in three period groups according to year of diagnosis: period 1, 1963-1982; period 2, 1983-1992; and period 3, 1993-2007. We recorded the histological type, age at diagnosis, and, in period 3, the type of pre-existing thyroid disease, the stage, and tumor size. Results: During periods 1, 2, and 3, the mean age at diagnosis was 37.7±12.3, 42.4±14.53, and 44.1±14.9 years (p=0.001), respectively, and the male to female ratio was similar. The prevalence of FTC was 22.7%, 28.1%, and 6.5%, respectively. In period 3, 51.6% of the PTCs were microcarcinomas (microPTC) ≤10mm; these patients tended to be older (p=0.09). Microcarcinomas were more frequent among patients operated for pre-existing multinodular goiter (MNG) or prominent hot nodule compared to pre-existing single cold nodule (p<0.001, Pearson χ2). In period 3, 88% of the microPTC diagnoses were incidental. Of the incidental microPTCs detected in MNG, 25% had capsular invasion, 4.5% had lymph node involvement, and 3.6% had soft tissue involvement. Conclusions: We hypothesize that the prevalence of FTC during the last decade in our center in Greece was very low due to correction of iodine deficiency and a relative increase in the prevalence of microPTC. More than 50% of PTC diagnosed during the last decade were microPTCs that were detected incidentally in older persons with preexisting MNG or a prominent hot nodule. This is one of the highest, if not the highest percentage of microPTCs that were incidentally detected. Despite many of these having features of invasiveness, most appear to remain clinically silent. Research is needed to identify factors predisposing microPTCs to evolve from a subclinical to a clinically apparent form. © 2009 Mary Ann Liebert, Inc.

In this study, an assessment of indoor air quality (IAQ) and thermal comfort in the Athens Traffic Control Tower (ATCT) offices of Hellinicon building complex, which is mechanically ventilated, is presented. Measurements of PM 10, PM 2.5, TVOCs and CO 2 concentrations were performed during three experimental cycles, while the Thom Discomfort Index was calculated to describe the employees’ feeling of discomfort. The aim of the first cycle was to identify the IAQ status, the second to investigate the effectiveness of certain measures taken, and the third to continuously monitor and control IAQ. During the first two cycles, daily spot measurements of TVOCs and CO 2 were performed at various indoor locations and at the respective outdoor air intake positions, in addition with mean 24-h spot measurements of indoor PM 10 and PM 2.5. Results revealed that pollution levels vary according to the occupancy and the kind of activity. Following that, an automated system (IMAS) was designed and employed to continuously monitor indoor and outdoor CO 2, TVOCs, temperature and relative humidity. The ultimate scope was to control the IAQ and offer acceptable comfort conditions to the employees, whose work is of special nature and extremely demanding. Intervention scenarios were formulated and applied to the system to improve indoor conditions, when and where necessary. Regarding the third cycle, 1-year measurements collected from the system to examine its effectiveness. While it was shown that discomfort may be attributed to co-existence of unsatisfactory thermal comfort conditions and IAQ, usually the sole predominant factor of discomfort feeling is thermal comfort. © Springer Science+Business Media B.V. 2008.

Primary penile tuberculosis associated with bilateral inguinal lymphadenopathy is described in a previously healthy 10-month old infant, who had been circumcised in Pakistan 4 months earlier. Mycobacterium tuberculosis was detected by acid fast stain, PCR and culture in specimens obtained from the penile ulcer and the excised inguinal lymph nodes.

AIM: In order to assess the effect of osteoporosis on healing time, the files of 165 patients with femoral shaft fractures that were treated in our institution with locked-reamed intramedullary nailing were retrospectively reviewed. PATIENTS AND METHODS: Patients with open fractures, pathological fractures, revision surgery, severe brain injuries and prolonged ITU stay were excluded. In all patients the Singh-index score for osteoporosis and the canal bone ratio (CBR) were assigned. Sixty-six patients fulfilled the inclusion criteria. Patients were divided into two groups; group A (29 patients) consisted of patients over 65 years old with radiological evidence of osteoporosis and group B (37 patients) of patients between 18 and 40 years old with no signs of osteoporosis. RESULTS: In all group A patients Singh score < or =4 and CBR>0.50 were assigned, suggesting the presence of osteoporosis, whereas all group B patients were assigned with Singh score > or =5 and CBR<0.48. Fractures of group A healed in 19.38+/-5.9 weeks (12-30) and in group B 16.19+/-5.07 weeks (10-28), P=0.02. CONCLUSIONS: Fracture healing of nailed femoral diaphyseal fractures is significantly delayed in older osteoporotic patients. Further studies are required to clarify the exact impact of osteoporosis in the whole healing process.

{cis-[Ru(bpy)2(Ln)]Cl2 (n = 1, L 1 = 4-carboxy-2-(2′-pyridyl)quinoline (2); n = 2

Objective: Modulating effects of genetic and environmental risk factors on severity of human abdominal aortic aneurysm (AAA) tissue inflammation remain unclear. We investigated the influence of total plasma homocysteine (tHcy) and traditional atherosclerotic risk factors (ARF) on degree of AAA tissue inflammation. Methods: Aneurysm specimens were obtained from 89 male patients aged 52 to 83 years, underwent asymptomatic not ruptured AAA (mean diameter 5.5 cm) open repair and graded for degree of histologic inflammation. Multivariate analysis was used to determine the association of tHcy and ARF, with degree of inflammation. Results: Current cigarette smoking, odds ratio (OR) 4.4, 95% confidence interval 1.3 to 15.2, P =.01 and no other ARF, neither tHcy levels OR 0.9 (0.9-1.02), P =.2 were associated with high-grade tissue inflammation. Conclusion: These results provide evidence against a major effect of tHcy levels on AAA tissue inflammation, while current cigarette smoking is a significant modulating factor.

Several imaging technologies are used for the diagnosis and management of patients with multiple myeloma (MM). Conventional radiography, computed tomography (CT), magnetic resonance imaging (MRI) and nuclear medicine imaging are all used in an attempt to better clarify the extent of bone disease and soft tissue disease in MM. This review summarizes all available data in the literature and provides recommendations for the use of each of the technologies. Conventional radiography still remains the 'gold standard' of the staging procedure of newly diagnosed and relapsed myeloma patients. MRI gives information complementary to skeletal survey and is recommended in MM patients with normal conventional radiography and in all patients with an apparently solitary plasmacytoma of bone. Urgent MRI or CT (if MRI is not available) is the diagnostic procedure of choice to assess suspected cord compression. Bone scintigraphy has no place in the routine staging of myeloma, whereas sequential dual-energy X-ray absorptiometry scans are not recommended. Positron emission tomography/CT or MIBI imaging are also not recommended for routine use in the management of myeloma patients, although both techniques may be useful in selected cases that warrant clarification of previous imaging findings, but such an approach should ideally be made within the context of a clinical trial. © 2009 Macmillan Publishers Limited All rights reserved.

The serum immunoglobulin-free light chain (FLC) assay measures levels of free κ and λ immunoglobulin light chains. There are three major indications for the FLC assay in the evaluation and management of multiple myeloma and related plasma cell disorders (PCD). In the context of screening, the serum FLC assay in combination with serum protein electrophoresis (PEL) and immunofixation yields high sensitivity, and negates the need for 24-h urine studies for diagnoses other than light chain amyloidosis (AL). Second, the baseline FLC measurement is of major prognostic value in virtually every PCD. Third, the FLC assay allows for quantitative monitoring of patients with oligosecretory PCD, including AL, oligosecretory myeloma and nearly two-thirds of patients who had previously been deemed to have non-secretory myeloma. In AL patients, serial FLC measurements outperform PEL and immunofixation. In oligosecretory myeloma patients, although not formally validated, serial FLC measurements reduce the need for frequent bone marrow biopsies. In contrast, there are no data to support using FLC assay in place of 24-h urine PEL for monitoring or for serial measurements in PCD with measurable disease by serum or urine PEL. This paper provides consensus guidelines for the use of this important assay, in the diagnosis and management of clonal PCD.

In 2005, the first guidelines were published on the management of patients with multiple myeloma (MM). An expert panel reviewed the currently available literature as the basis for a set of revised and updated consensus guidelines for the diagnosis and management of patients with MM who are not eligible for autologous stem cell transplantation. Here we present recommendations on the diagnosis, treatment of newly diagnosed non-transplant-eligible patients and the management of complications occurring during induction therapy among these patients. These guidelines will aid the physician in daily clinical practice and will ensure optimal care for patients with MM.

Multiple myeloma is the most common indication for high-dose chemotherapy with autologous stem cell support (ASCT) in North America today. Stem cell procurement for ASCT has most commonly been performed with stem cell mobilization using colony-stimulating factors with or without prior chemotherapy. The target CD34+ cell dose to be collected as well as the number of apheresis performed varies throughout the country, but a minimum of 2 million CD34+ cells/kg has been traditionally used for the support of one cycle of high-dose therapy. With the advent of plerixafor (AMD3100) (a novel stem cell mobilization agent), it is pertinent to review the current status of stem cell mobilization for myeloma as well as the role of autologous stem cell transplantation in this disease. On June 1, 2008, a panel of experts was convened by the International Myeloma Foundation to address issues regarding stem cell mobilization and autologous transplantation in myeloma in the context of new therapies. The panel was asked to discuss a variety of issues regarding stem cell collection and transplantation in myeloma especially with the arrival of plerixafor. Herein, is a summary of their deliberations and conclusions.

Recently, many new drugs have been developed for the treatment of Waldenström macroglobulinemia (WM). To optimize the treatment according to the prognosis and to facilitate the comparison of trials, we developed an International Prognostic Scoring System for WM in a series of 587 patients with clearly defined criteria for diagnosis and for initiation of treatment. The median survival after treatment initiation was 87 months. Five adverse covariates were identified: advanced age (>65 years), hemoglobin less than or equal to 11.5 g/dL, platelet count less than or equal to 100 × 10 9/L, β2-microglobulin more than 3 mg/L, and serum monoclonal protein concentration more than 7.0 g/dL. Low-risk patients (27%) presented with no or 1 of the adverse characteristics and advanced age, intermediate-risk patients (38%) with 2 adverse characteristics or only advanced age, and high-risk patients (35%) with more than 2 adverse characteristics. Five-year survival rates were 87%, 68%, and 36%, respectively (P < .001). The ISSWM retained its prognostic significance in subgroups defined by age, treatment with alkylating agent, and purine analog. Thus, the ISSWM may provide a means to design risk-adapted studies. However, independent validation and new biologic markers may enhance its significance. © 2009 by The American Society of Hematology.

Resource availability, competition, and predation commonly drive body size evolution. We assess the impact of high food availability and the consequent increased intraspecific competition, as expressed by tail injuries and cannibalism, on body size in Skyros wall lizards ( Podarcis gaigeae ). Lizard populations on islets surrounding Skyros (Aegean Sea) all have fewer predators and competitors than on Skyros but differ in the numbers of nesting seabirds. We predicted the following: (1) the presence of breeding seabirds (providing nutrients) will increase lizard population densities; (2) dense lizard populations will experience stronger intraspecific competition; and (3) such aggression, will be associated with larger average body size. We found a positive correlation between seabird and lizard densities. Cannibalism and tail injuries were considerably higher in dense populations. Increases in cannibalism and tail loss were associated with large body sizes. Adult cannibalism on juveniles may select for rapid growth, fuelled by high food abundance, setting thus the stage for the evolution of gigantism.

Intestinal obstruction in neonatal period is an emergency caused by many surgical causes. An extremely rare surgical cause in this group of age is intussusception which can be easily confused with other surgical entities. In several reports, a significant number of the infants who were included in the study population were believed to have necrotizing enterocolitis (NEC). We present a rare cause of small intestine obstruction in a preterm female infant that can be easily misdiagnosed and confused preoperatively with other clinical entities particular for this period.

The paper describes a study of the contexts of six teams, expert in research and development of digital media for learning mathematics, who cross-experimented in classrooms with the use of each other’s artefacts. Contextual issues regarding the designed tasks and technologies, the socio-systemic milieu and the ways in which the researchers worked with the teachers were in focus. We analysed the ways in which a set of mutually constructed and negotiated questions aiming to illuminate otherwise tacit contextual issues operated as boundary objects amongst the teams. We discuss the need to develop special tools such as these boundary objects in order to elicit issues of context and the ways they may affect the production of theory.

We study theoretically the optical properties of embedded Ge and Si nanocrystals (NCs) in wide band-gap matrix and compared the obtained results for both NCs embedded in SiO2 matrix. We calculate the ground and excited electron and hole levels in both Ge and Si nanocrystals (quantum dots) in a multiband effective mass approximation. We use the envelope function approximation taking into account the elliptic symmetry of the bottom of the conduction band and the complex structure of the top of the valence band in both Si and Ge (NCs). The Auger recombination (AR) in both nanocrystals is thoroughly investigated. The excited electron (EE), excited hole (EH) and biexciton AR types are considered. The Auger recombination (AR) lifetime in both NCs has been estimated and compared. Crown Copyright © 2009.

This study was undertaken to assess the impact of a single excessive sludge application (300 Mg ha-1) on the soil surface of an olive orchard several years after the event. Selected soil properties were compared in two soil profiles, one in the sludge-amended field and another in an adjacent unamended field of naturally growing trees. Leaf analysis included macronutrients [nitrogen (N), phosphorus (P), potassium (K), calcium (Ca), magnesium (Mg)], trace elements [copper (Cu), zinc (Zn), manganese (Mn), iron (Fe), nickel (Ni), boron (B)], and isotopic composition (δ 15N and δ 13C). Soil pH and other chemical properties were increased in the surface soil and the root zone of the sludge-treated profile in comparison to those of the untreated control. The multifold increase of Bray P and nitrates indicated a serious risk for dissolved phosphates in runoff and nitrate contamination of groundwater. Trace-element content also increased, but not greater than the critical soil concentration. Olive trees responded to excessive sludge application by increased N uptake as evidenced by increased leaf N content and elevated 15N signal. The increased leaf δ 13C signal of the leaves further indicated tree stress in the sludge-amended field during the summer growing season in comparison to the naturally growing control trees. Isotopic composition, leaf nutrient, and trace element concentration did not reveal the causes of leaf tip burning in half of the trees of the sludge-amended field. Copyright © Taylor & Francis Group, LLC.

BACKGROUND: Ischemia modified albumin (IMA), is a new biomarker of oxidative processes involved with coronary artery disease (CAD). We determined serum IMA, high-sensitivity C-reactive protein (hsCRP), and natriuretic peptide (NT-proBNP), and evaluated their correlation with severity of coronary atherosclerosis in patients undergoing coronary angiography (CA). Cardiac troponin T (cTnT), CK-MB mass, albumin and Total Antioxidant Status (TAS) were also evaluated. METHODS: The study included 114 patients (88 men and 30 women) aged 43-80 years with documented CAD without evidence of acute coronary syndrome undergoing CA and 163 controls (131 men and 32 women) similarly aged. RESULTS: IMA, hsCRP and NT-proBNP were higher (p<0.001 and p=0.008 for NT-proBNP) while TAS was lower (p<0.001) in patients than in controls. IMA and TAS were negatively correlated in all subjects (p<0.01). Among patients, there was no correlation between IMA and the number of diseased vessels. For CAD diagnosis the best cut-off point for IMA was 101.5 KU/L with a sensitivity and a specificity of 87.7% and a negative predictive value of 83.3%. IMA was associated with an increased risk for CAD (OR=1.23, 95% CI: 1.16-1.31; p<0.001). CONCLUSIONS: IMA determination may provide earlier information of CAD presence before hsCRP or NT-proBNP elevation, contributing to early assessment of overall patient risk.

The Itea-Amfissa valley, separating Giona Mountain to the west from Parnassos Mountain to the east, is related to an extensional detachment observed along the eastern slopes of Giona. The detachment is traced for 30 km north of the Corinth Gulf and dips 25{degrees}-40{degrees} to the east, showing an east-west extension parallel to the Hellenic arc. The lower nappes of Pindos, Penteoria, Vardoussia and mainly the basal thrust of the Parnassos unit form part of the footwall, whereas the upper thrusts of the Parnassos unit and the Western Thessaly-Beotia nappe form part of the hanging wall. The eastern slopes of Giona are controlled by the detachment and several hundred metres of syn-tectonic breccia-conglomerates are observed at the top of the hanging wall rocks and are back-tilt towards the detachment plane. Two conglomeratic sequences are distinguished: the lower one consists of argillaceous matrix and abundant ophiolite detritus whereas the upper one bears carbonate matrix with carbonate detritus together with large olistholites of Mesozoic limestones. Based on calcareous nannofossils a middle Miocene age has been determined for the lower formation and a middle-upper Miocene age is probable for the upper. Planation surfaces cut on top of the sediments rise from south to north starting from sea level at Galaxidi to about 1400 m at Prosilio. The throw of the detachment is about 2.5-4.2 km measured mainly from the structural omission of the Alpine tectono-stratigraphic units. A contrast between the footwall and the hanging wall structure is described, with monoclinic sequence of the Parnassos nappe dipping to the west in the footwall but a complex synsedimentary horst and graben structure of sliding blocks of Alpine formations within the Miocene clastic sequences in the hanging wall. The detachment has been deformed by the east-west-trending steep normal faults that have created the Corinth rift during late Pliocene-Quaternary time showing a north-south extension. The Itea-Amfissa detachment forms the northern tip of the broader East Peloponnesus detachment, observed south of the Corinth rift structure from Feneos to Kyparissi. Similar geodynamic phenomena with large olistholites and breccia conglomerates are known from the Serravalian of Crete, related to the activity of the Cretan detachment.

Outflows in the form of jets is a widespread phenomenon in astrophysics. Their main driving mechanism is likely related to magnetic fields. These fields are able to tap the rotational energy of the central object and its surrounding disk, and accelerate and collimate matter ejecta. To zeroth order these outflows can be described within the theory of steady, axisymmetric, ideal magnetohydrodynamics (MHD). The analytical insight into the equations of the theory (mostly on the transfield component of the momentum equation) gives simple analytical scalings for the flow speed, density, and magnetic field. The analysis is focused on nonrelativistic YSO jets; similar works [1, 2] exist for relativistic AGN, and highly relativistic GRB jets.

Outflows in the form of jets is a widespread phenomenon in astrophysics. Their main driving mechanism is likely related to magnetic fields. These fields are able to tap the rotational energy of the central object and its surrounding disk, and accelerate and collimate matter ejecta. To zeroth order these outflows can be described within the theory of steady, axisymmetric, ideal magnetohydrodynamics (MHD). The analytical insight into the equations of the theory (mostly on the transfield component of the momentum equation) gives simple analytical scalings for the flow speed, density, and magnetic field. The analysis is focused on nonrelativistic YSO jets; similar works [1, 2] exist for relativistic AGN, and highly relativistic GRB jets.

We exploit the decoherence of electrons due to magnetic impurities, studied via weak localization, to resolve a long-standing question concerning the classic Kondo systems of Fe impurities in the noble metals gold and silver: which Kondo-type model yields a realistic description of the relevant multiple bands, spin, and orbital degrees of freedom? Previous studies suggest a fully screened spin S Kondo model, but the value of S remained ambiguous. We perform density functional theory calculations that suggest S = 3/2. We also compare previous and new measurements of both the resistivity and decoherence rate in quasi-one-dimensional wires to numerical renormalization group predictions for S = 1/2, 1, and 3/2, finding excellent agreement for S = 3/2.

À travers une approche comparative, la présente étude confronte les récits des voyageurs français du XVIIe siècle, qui ont parcouru l’Orient méditerranéen, au « livre des voyages » d’Evliya Çelebi. Après avoir abordé les relations diplomatiques franco-ottomanes, nous traitons de l’image de l’Empire ottoman communiquée dans les récits, les journaux et les traités des voyageurs français. Plus précisément, nous présentons les récits de Pierre Giles, Jean Thévenot, Joseph-Guillaume Grelot, La Croix et Antoine des Barrès, dont nous analysons les informations relatives à l’administration, la société, la religion et l’art ottomans. Contrairement à la structure déjà formée du récit viatique français, qui exprime l’approche ethnocentriste de ses auteurs, le « livre des voyages », qui dévoile la perception d’un Ottoman, ne suit pas de règles préétablies. Ainsi, à l’opposé des récits viatiques français, qui se réfèrent à la décadence de la force et du prestige du sultan, comme dans le cas des Mémoires de La Croix, le « livre des voyages » de Çelebi, qui comprend souvent des digressions sur la personnalité et les fonctions de Melek Ahmed Pacha, s’attarde sur la puissance du sultan ainsi que sur la structure et les caractéristiques de la hiérarchie de la société ottomane. Notons que la subjectivité des récits des voyageurs français du XVIIe et de Çelebi, malgré la richesse de leurs informations, nous oblige à les traiter avec précaution.

New micropaleontological, palynological, and geochemical results from a relatively shallow (∼500 m) sediment core (NS-14) in the south-eastern Aegean Sea provide a detailed picture of the regional expression of sapropel S1 formation in this sub-basin of the eastern Mediterranean Sea. Specifically, freshwater input during ∼10.6–10.0 ka BP has preceded the deposition of S1. Further decrease in surface water salinity is evidenced between 10.0 and 8.5 ka BP at the lower part of S1a, which in respect to S1b, is featured by warmer (∼19.5 °C) and more productive surface waters associated with dysoxic bottom conditions. A series of coolings detected within the S1 depositional interval, may be linked to outbursts of cold northerly air masses and relevant pulses in the deep-intermediate water ventilation that caused the S1 interruption between 7.9 and 7.3 ka BP and culminated during the deposition of S1b, with the decline of deep chlorophyll maximum (DCM) at ∼6.5 ka BP. The climate instability and the relevant absence of anoxia weakened the organic matter preservation in the shallow south-eastern Aegean margin during the S1 times. NS-14 record provides evidence for a distinct mid Holocene warm (up to ∼25 °C) and wet phase associated with the deposition of the sapropel-like layer SMH (Sapropel Mid Holocene), between 5.4 and 4.3 ka BP. The SMH layer could represent evidence of on-going, albeit weak, African monsoon forcing, only expressed at the south-eastern edge of the Aegean Sea. Its end is associated with the 4.2 ka BP Northern Hemisphere megadrought event and the termination of the African Humid Period at 3.8 ka BP.

Quantitative analyses of coccolithophores, planktonic foraminifers, dinoflagellate cysts and pollen assemblages were carried out on shallow (NS-14) and deeper (NS-40) sediment cores from the south-eastern Aegean Sea. Nine coccolithophore (ACE 1–9) and nine planktonic foraminifer (APFE 1–9) ecozones, correlated with dinoflagellate cyst evidence, have been defined for the last ~14.5 cal. ka. Additionally, eight pollen assemblage zones (PAZ 1–8) have been recognised and correlated with the plankton ecozones. Although generally consistent with existing schemes for the central and eastern Mediterranean, the established high resolution ecostratigraphy has led to an expanded palaeoecological reconstruction of the Late Glacial–Holocene archive in the south-eastern Aegean Sea, defining two warm and humid phases at 9.3–8.6 and 7.6–6.4 cal. ka B.P., associated with the deposition of the early Holocene sapropel S1, and a third one between 5.2 and 4.2 cal. ka B.P. The high sedimentation rates which characterise the study area enabled the detection of even minor and brief climatic events in the Aegean Sea during S1 deposition times. 

This subset analysis of data from two phase III studies in patients with relapsed or refractory multiple myeloma (MM) evaluated the benefit of initiating lenalidomide plus dexamethasone at first relapse. Multivariate analysis showed that fewer prior therapies, along with β2-microglobulin (≤2.5 mg/L), predicted a better time to progression (TTP; study end-point) with lenalidomide plus dexamethasone treatment. Patients with one prior therapy showed a significant improvement in benefit after first relapse compared with those who received two or more therapies. Patients with one prior therapy had significantly prolonged median TTP (17.1 vs. 10.6 months; P = 0.026) and progression-free survival (14.1 vs. 9.5 months, P = 0.047) compared with patients treated in later lines. Overall response rates were higher (66.9% vs. 56.8%, P = 0.06), and the complete response plus very good partial response rate was significantly higher in first relapse (39.8% vs. 27.7%, P = 0.025). Importantly, overall survival was significantly prolonged for patients treated with lenalidomide plus dexamethasone with one prior therapy, compared with patients treated later in salvage (median of 42.0 vs. 35.8 months, P = 0.041), with no differences in toxicity, dose reductions, or discontinuations despite longer treatment. Therefore, lenalidomide plus dexamethasone is both effective and tolerable for second-line MM therapy and the data suggest that the greatest benefit occurs with earlier use. © 2009 Blackwell Munksgaard.

Recent studies have shown a clinical benefit of lenalidomide, an oral immunomodulatory drug, plus dexamethasone in patients with relapsed/refractory multiple myeloma (MM). The most common grade 3-4 adverse events were cytopenias, fatigue, muscle cramps, rash, infection, insomnia, and venous thromboembolism. Lenalidomide in combination with dexamethasone has been approved by the United States Food and Drug Administration and the European Medicines Agency for the treatment of patients with MM who have received at least one prior therapy. An expert panel reviewed the efficacy and toxicity of lenalidomide plus dexamethasone, and provided recommendations on the management of patients receiving this treatment. Patient selection is straightforward, as prognostic factors do not appear to heavily influence efficacy. In addition, the panel agreed on strategies for the management of side effects. The recommendations presented here will aid the safe administration of lenalidomide, and avoid unnecessary dose reduction and discontinuation, thus assuring the best efficacy of treatment. © 2008 Elsevier Ltd. All rights reserved.

We present a pooled update of two large, multicenter MM-009 and MM-010 placebo-controlled randomized phase III trials that included 704 patients and assessed lenalidomide plus dexamethasone versus dexamethasone plus placebo in patients with relapsed/refractory multiple myeloma (MM). Patients in both studies were randomized to receive 25mg daily oral lenalidomide or identical placebo, plus 40mg oral dexamethasone. In this pooled analysis, using data up to unblinding (June 2005 for MM-009 and August 2005 for MM-010), treatment with lenalidomide plus dexamethasone significantly improved overall response (60.6 vs 21.9%, P<0.001), complete response rate (15.0 vs 2.0%, P<0.001), time to progression (median of 13.4 vs 4.6 months, P<0.001) and duration of response (median of 15.8 months vs 7 months, P<0.001) compared with dexamethasone-placebo. At a median follow-up of 48 months for surviving patients, using data up to July 2008, a significant benefit in overall survival (median of 38.0 vs 31.6 months, P=0.045) was retained despite 47.6% of patients who were randomized to dexamethasone-placebo receiving lenalidomide-based treatment after disease progression or study unblinding. Low β2- microglobulin and low bone marrow plasmacytosis were associated with longer survival. In conclusion, these data confirm the significant response and survival benefit with lenalidomide and dexamethasone.

Accumulating evidence supports a role for obesity in the etiology of multiple myeloma (MM). The distinct possibility exists that obesity may be linked to MM through altered adipokine secretion and circulating levels, one of which, adiponectin, has a protective role in several malignancies, including leukemia. In this case-control study, we investigated the role of serum adiponectin, resistin, and leptin levels in the etiopathogenesis of MM and we explored their association with several established prognostic factors. Seventy three patients with incident, histologically confirmed MM and 73 controls matched on gender and age were studied between 2001 and 2007, and blood samples were collected. Serum adiponectin, leptin, resistin, as well as MM prognostic parameters were determined. Statistical analysis of the data was performed using univariate and multivariate analyses. Lower serum adiponectin and resistin levels were associated with higher risk of MM by bivariate analysis and after adjusting for age, gender, BMI, and serum levels of leptin (p < 0.0001). Adiponectin may have a protective role in MM, whereas leptin was not associated with risk for MM at a comparable level of significance and resistin levels may be decreased via a compensatory mechanism. Further studies are needed to confirm these associations and to explore the mechanisms underlying adiponectin's role in MM and plasma cell dyscrasias.

Weather maps refer to meteorological data that characterize the atmospheric circulation in a region. The classification of weather maps into categories becomes an important task for understanding regional climate. Towards this goal, manual and semiautomatic techniques have been used, requiring manpower and supervision. In this paper, we propose a machine vision based method for the classification of weather maps into distinct classes. The chain code descriptor is applied to extract the feature of isobaric lines and we introduce the Double-Side Chain Code (DSCC) histogram for feature representation. Handling DSCC histograms as multidimensional vectors, the A:-nearest neighbors (k- NN) algorithm classifies the objects to an appropriate number of classes, based on closest training set in the feature space. This method provides an automated and more ’objective’ classification scheme, applying straightforward to the input weather map’s image. © 2009 IEEE.

We present numerical simulations of axisymmetric, magnetically driven outflows that reproduce the inferred properties of ultrarelativistic gamma-ray burst (GRB) jets. These results extend our previous simulations of outflows accelerated to moderately relativistic speeds, which are applicable to jets of active galactic nuclei. In contrast to several recent investigations, which have employed the magnetodynamics approximation, our numerical scheme solves the full set of equations of special relativistic, ideal magnetohydrodynamics, which enables us to explicitly calculate the jet velocity and magnetic-to-kinetic energy conversion efficiency - key parameters of interest for astrophysical applications. We confirm that the magnetic acceleration scheme remains robust into the ultrarelativistic regime, as previously indicated by semi-analytic self-similar solutions. We find that all current-carrying outflows exhibit self-collimation and consequent acceleration near the rotation axis, but that unconfined outflows lose causal connectivity across the jet and therefore do not collimate or accelerate efficiently in their outer regions. We show that magnetically accelerated jets confined by an external pressure that varies as z-α (0 < α <= 2) assume a paraboloidal shape z ~ ra (where r,z are cylindrical coordinates and a > 1), and we obtain analytic expressions for the one-to-one correspondence between the pressure distribution and the asymptotic jet shape. We demonstrate that the acceleration efficiency of jets with paraboloidal streamlines is >~50 per cent, with the numerical value being higher the lower the initial magnetization. We derive asymptotic analytic expressions for the acceleration of initially cold outflows along paraboloidal streamlines and verify that they provide good descriptions of the simulated flows. Our modelled jets (corresponding to 3/2 < a < 3) attain Lorentz factors Γ >~ 102 on scales ~ 1010-1012cm, consistent with the possibility that long/soft GRB jets are accelerated within envelopes of collapsing massive stars, and Γ >~ 30 on scales ~9 × 108-3 × 1010cm, consistent with the possibility that short/hard GRB jets are accelerated on scales where they can be confined by moderately relativistic winds from accretion discs. We also find that Γθv ~ 1 for outflows that undergo an efficient magnetic-to-kinetic energy conversion, where θv is the opening half-angle of the poloidal streamlines. This relation implies that the γ-ray emitting components of GRB outflows accelerated in this way are very narrow, with θv <~ 1° in regions where Γ >~ 100, and that the afterglow light curves of these components would either exhibit a very early jet break or show no jet break at all.

We present numerical simulations of axisymmetric, magnetically driven outflows that reproduce the inferred properties of ultrarelativistic gamma-ray burst (GRB) jets. These results extend our previous simulations of outflows accelerated to moderately relativistic speeds, which are applicable to jets of active galactic nuclei. In contrast to several recent investigations, which have employed the magnetodynamics approximation, our numerical scheme solves the full set of equations of special relativistic, ideal magnetohydrodynamics, which enables us to explicitly calculate the jet velocity and magnetic-to-kinetic energy conversion efficiency - key parameters of interest for astrophysical applications. We confirm that the magnetic acceleration scheme remains robust into the ultrarelativistic regime, as previously indicated by semi-analytic self-similar solutions. We find that all current-carrying outflows exhibit self-collimation and consequent acceleration near the rotation axis, but that unconfined outflows lose causal connectivity across the jet and therefore do not collimate or accelerate efficiently in their outer regions. We show that magnetically accelerated jets confined by an external pressure that varies as z-α (0 < α <= 2) assume a paraboloidal shape z ~ ra (where r,z are cylindrical coordinates and a > 1), and we obtain analytic expressions for the one-to-one correspondence between the pressure distribution and the asymptotic jet shape. We demonstrate that the acceleration efficiency of jets with paraboloidal streamlines is >~50 per cent, with the numerical value being higher the lower the initial magnetization. We derive asymptotic analytic expressions for the acceleration of initially cold outflows along paraboloidal streamlines and verify that they provide good descriptions of the simulated flows. Our modelled jets (corresponding to 3/2 < a < 3) attain Lorentz factors Γ >~ 102 on scales ~ 1010-1012cm, consistent with the possibility that long/soft GRB jets are accelerated within envelopes of collapsing massive stars, and Γ >~ 30 on scales ~9 × 108-3 × 1010cm, consistent with the possibility that short/hard GRB jets are accelerated on scales where they can be confined by moderately relativistic winds from accretion discs. We also find that Γθv ~ 1 for outflows that undergo an efficient magnetic-to-kinetic energy conversion, where θv is the opening half-angle of the poloidal streamlines. This relation implies that the γ-ray emitting components of GRB outflows accelerated in this way are very narrow, with θv <~ 1° in regions where Γ >~ 100, and that the afterglow light curves of these components would either exhibit a very early jet break or show no jet break at all.

By means of magnetic measurements we have studied the magnetic properties of the NdFeAsO0.82F0.18 superconductor. We estimated the upper critical field H-c2(ab) (T) from the temperature at which the inverse magnetization deviates from linear behavior. Low field magnetic measurements revealed that a external magnetic induction of B = 0.01 T destroys the superconducting path between grains (weak-link behavior). Nd ions behave as isolated paramagnetic centers. This is evident since for magnetic inductions larger than 0.5 T a paramagnetic moment arises from the Nd that overcomes the superconducting diamagnetic signal. Hysteresis loops at several temperatures revealed that the critical current falls rapidly with temperature. The temperature variation of the reversible magnetization shows a behavior that is reminiscent of high-T-c cuprates, indicating the important role of thermal fluctuations.

Uterine sarcomas constitute a rare group of neoplasms characterized by an aggressive clinical course and poor prognosis. It is this rarity that has resulted in clinical-trial reports and literature reviews including a broad range of histological subtypes of sarcoma. This has a detrimental effect on interpretation and application of the results; the pathological subtype demands a tailored approach. Surgical resection remains the mainstay of treatment for non metastatic uterine sarcomas. Although adjuvant radiation therapy has reportedly been of little survival value, it appears to improve local control and may delay recurrence. The role of adjuvant chemotherapy has yet to be established; however, bearing in mind the limitations and assumptions in the pooling of data the therapeutic options should be based on the pathological subtype. Considering the poor overall survival in uterine sarcomas, the need for new therapeutic agents is critical. New drugs with possible activity in uterine sarcomas include trabectedin, temozolomide, liposomal doxorubicin and gemcitabine.

INTRODUCTION: Bile duct injury is a severe and potentially life-threatening complication of laparoscopic cholecystectomy. Several series have described a 0.5% to 0.6% incidence of bile duct injury during laparoscopic cholecystectomy. The aim of this study was to analyze the presentation, characteristics, related investigation, and treatment results of major bile duct injuries after laparoscopic cholecystectomy. CASE PRESENTATION: A rare case of a 48-year-old Greek woman with a triple bile duct injury (right and left hepatic duct ligation and common bile duct cross-section) is presented. A Roux en Y hepaticojejunostomy was performed after repeated endoscopic retrograde cholangiopancreatographies, percutaneous transhepatic catheterization of the ducts and magnetic resonance cholangiographies to delineate the biliary anatomy and assess the level of injury. CONCLUSION: Early recognition and an adequate multidisciplinary approach are the cornerstones for the optimal final outcome. Suboptimal management of injuries often leads to more extensive damage to the biliary tree and its vasculature. Early referral to a tertiary care center with experienced hepatobiliary surgeons and skilled interventional radiologists would appear to be necessary to assure optimal results.

This paper reports on a case-study design experiment in the domain of fraction as number-measure. We designed and implemented a set of exploratory tasks concerning comparison and ordering of fractions as well as operations with fractions. Two groups of 12-year-old students worked collaboratively using paper and pencil as well as a specially designed microworld which combines graphical and symbolic notation of fractions represented as points on the number line. We used the students’ interactions with the available representations as a window into their conceptual understanding and struggles in making sense of fraction asnumber-measure. We report on the features of the available representations from an epistemological point of view, on the design of activities aiming at creating meaningful problem contexts for fractions as well as on the meanings generated by the students by some illustrative examples of their work indicating the potential of the activities and tools for expressing and reflecting on the mathematical nature of fraction as number-measure.

During the peak of an extensive heat wave episode on 23-25 July 2007, simultaneous thermophysiological measurements were made in two non-acclimated healthy adults of different sex in a suburban area of Greater Athens, Greece. Based on experimental measurements of mean skin temperature and metabolic heat production, heat fluxes to and from the human body were calculated, and the biometeorological index heat load (HL) produced was determined according to the heat balance equation. Comparing experimental values with those derived from theoretical estimates revealed a great heat stress for both individuals, especially the male, while theoretical values underestimated heat stress. The study also revealed that thermophysiological factors, such as mean skin temperature and metabolic heat production, play an important role in determining heat fluxes patterns in the heat balance equation. The theoretical values of mean skin temperature as derived from an empirical equation may not be appropriate to describe the changes that take place in a non-acclimated individual. Furthermore, the changes in metabolic heat production were significant even for standard activity. © 2008 ISB.

BACKGROUND: Higher adherence to the Mediterranean diet (MeDi) may protect from Alzheimer disease (AD), but its association with mild cognitive impairment (MCI) has not been explored. OBJECTIVE: To investigate the association between the MeDi and MCI. DESIGN, SETTING, AND PATIENTS: In a multiethnic community study in New York, we used Cox proportional hazards to investigate the association between adherence to the MeDi (0-9 scale; higher scores indicate higher adherence) and (1) the incidence of MCI and (2) the progression from MCI to AD. All of the models were adjusted for cohort, age, sex, ethnicity, education, APOE genotype, caloric intake, body mass index, and duration between baseline dietary assessment and baseline diagnosis. MAIN OUTCOME MEASURES: Incidence of MCI and progression from MCI to AD. RESULTS: There were 1393 cognitively normal participants, 275 of whom developed MCI during a mean (SD) follow-up of 4.5 (2.7) years (range, 0.9-16.4 years). Compared with subjects in the lowest MeDi adherence tertile, subjects in the middle tertile had 17% less risk (hazard ratio [HR] = 0.83; 95% confidence interval [CI], 0.62-1.12; P = .24) of developing MCI and those in the highest tertile had 28% less risk (HR = 0.72; 95% CI, 0.52-1.00; P = .05) of developing MCI (trend HR = 0.85; 95% CI, 0.72-1.00; P for trend = .05). There were 482 subjects with MCI, 106 of whom developed AD during a mean (SD) follow-up of 4.3 (2.7) years (range, 1.0-13.8 years). Compared with subjects in the lowest MeDi adherence tertile, subjects in the middle tertile had 45% less risk (HR = 0.55; 95% CI, 0.34-0.90; P = .01) of developing AD and those in the highest tertile had 48% less risk (HR = 0.52; 95% CI, 0.30-0.91; P = .02) of developing AD (trend HR = 0.71; 95% CI, 0.53-0.95; P for trend = .02). CONCLUSIONS: Higher adherence to the MeDi is associated with a trend for reduced risk of developing MCI and with reduced risk of MCI conversion to AD.

Abstract Pataky, K., Villanueva, G., Liani, A., Zgheib, O., Jenkins, N., Halazonetis, D. J., Halazonetis, T. D. and Brugger, J. Microcollimator for Micrometer-Wide Stripe Irradiation of Cells Using 20-30 keV X Rays. Radiat. Res. 172, 252-259 (2009). The exposure of subnuclear compartments of cells to ionizing radiation is currently not trivial. We describe here a collimator for micrometer-wide stripe irradiation designed to work with conventional high-voltage X-ray tubes and cells cultured on standard glass cover slips. The microcollimator was fabricated by high-precision silicon micromachining and consists of X-ray absorbing chips with grooves of highly controlled depths, between 0.5-10 microm, along their surfaces. These grooves form X-ray collimating slits when the chips are stacked against each other. The use of this device for radiation biology was examined by irradiating human cells with X rays having energies between 20-30 keV. After irradiation, p53 binding protein 1 (53BP1), a nuclear protein that is recruited at sites of DNA double-strand breaks, clustered in lines corresponding to the irradiated stripes.

The benefits of a minimally invasive approach are now well documented in adult women, and thus surgeons have embraced the notion of expanding such expertise in adolescence with measured enthusiasm and a great sense of responsibility. Faster recovery is likely to have a positive impact on schooling, while less adhesion formation may reduce future fertility issues. Gynaecologists performing minimally invasive procedures in adolescents ought to be aware of the steep learning curve required for achieving proficiency with complex laparoscopic surgery. In the group of rare congenital anomalies and advanced endometriosis, the best surgical results can only be achieved after careful preoperative planning by a multidisciplinary team © 2008 The Authors.

Mitral valve prolapse (MVP) is a benign valvular abnormality. However, an increased prevalence of MVP is reported in patients with systemic lupus erythematosus and autoimmune thyroid disease. Our aim was to evaluate whether the presence of MVP in healthy individuals might indicate a premature index of subclinical autoimmune disorder. A total of 75 individuals with MVP and 44 individuals without MVP were identified by echocardiography. Serum samples were examined for various organ and non-organ specific autoantibodies. In all, 35 of the 75 individuals with MVP had at least one autoantibody. ANA were detected in 17/75 in MVP(+) versus 1/44 in the MVP(-), (P < 0.05), and anti-ENA in 6/75 in the MVP(+) versus 0/44 in the control group, P = ns. In the MVP(+) group, thyroid autoantibodies, IgA and IgG RF were found at a statistically significant higher incidence, 16/75, 11/75 and 10/75 versus 1/44, 0/44 and 0/44 in the MVP(-)group, respectively (P < 0.05). The levels of IgG anticardiolipin antibodies were significantly higher in the MVP(+) group, P < 0.05. The presence of organ and non-organ specific autoantibodies in young healthy MVP(+) individuals insinuate the presence of subclinical autoimmunity and might suggest that autoimmune mechanisms might be involved in its pathogenesis. A follow-up of these individuals might elucidate whether MVP constitutes an early index of autoimmunity. © 2009 SAGE Publications.

After a brief description of the multiple-scattering method for photonic crystals, we present some results obtained by this method, relating to various types of plasmonic nanostructures in one, two and three dimensions: cavity plasmon waveguides, systems of metallic particles, and arrays of metallic shells. We analyse the optical response of these structures and emphasise some interesting aspects of the underlying physics.