Venom immunotherapy (VIT) has been shown to be an effective and safe treatment for preventing sting-induced anaphylaxis in patients with systemic reactions to hymenoptera stings. A remaining problem is the relative effectiveness and safety of different immunotherapy protocols used with respect to maintenance dose, injection interval, and duration.|We aimed to describe a modified cluster VIT protocol with a maintenance dose of 50 μg lasting 5 yr and to evaluate retrospectively its safety and efficacy in children.|Fifty four children 9.5±3.2 yr old with a history of at least one anaphylactic reaction to hymenoptera stings underwent VIT between 1995 and 2006. The identification of the offending insect(s) was based on patient's report and documented with in-vivo (SPTs and IDs) and in-vitro (RAST/CAP) test results. A modified cluster outpatient protocol lasting 5 wks, reaching a maintenance dose of 50 μg was followed according to clinical history and test results. After the maintenance dose was achieved, the followed injection-intervals were 4 wks for the first year, 5 wks for the 2nd year and 3rd year, and 6 wks for the last 2 yr.|Of the 54 children, 52 tolerated the 50 μg VIT protocol without side effects. Twenty one of them reported at least one field sting from at least one of the culprit, for their allergy, insects, 6±3.5 yr after they have started VIT treatment. In 11 of them, sting occurred 3.5±2.9 yr after the VIT was completed, whereas the other 10 of them during immunotherapy, 3.2±1.4 yr after they have started VIT. In the remaining two children, the maintenance dose was increased to 100 μg due to systemic reactions from the VIT. The data reflect outcomes 6-16 yr after the patients' initial allergic reaction.|VIT with 50 μg maintenance dose lasting 5 yr appears to be safe and effective enough to induce tolerance in children with hymenoptera venom hypersensitivity.

Scar endometriosis is an under-appreciated or misdiagnosed phenomenon in general surgery and may eventually be more common than reflected in the literature. We herein report five cases of scar endometriosis that were treated in our surgical department one to five years after Caesarean section. Scar endometriosis should be considered when the symptoms are present in a cyclic manner mostly after gynaecological operations and worsening during menstruation. Diagnosis is mainly based upon a high index ofsuspicion. The treatment of choice is surgical resection.

The objective of this study was to explore the ability of 3 regional climate models (RCMs), CNRM-Aladin, C4I-RCA3 and KNMI-RACMO along with their parental global climate models (GCMs), ARPEGE and ECHAM5, to represent the relationship between large-scale atmospheric circulation and climate extremes in the Mediterranean region. Subsequently, an evaluation and inter-comparison of these 3 RCM/GCM couples for the present climate was performed. For this purpose, the Regularised Canonical Correlation Analysis (RCCA) was employed and 4 extreme climate indices of temperature and precipitation were used to define extreme events over the study region. The evaluation of these relationships was carried out against gridded observational and reanalysis datasets. It was found that the observed upper air large scale patterns related to climate extremes in the Mediterranean are not very well reproduced by the RCM/GCM couples in all seasons. In addition, in many cases, the coupled models display patterns of extreme climate indices which are not consistent with the accompanied upper level circulation. Furthermore, all coupled models display substantial deficiencies in simulating precipitation extremes. In the case of summer data, the ability of all 3 models is limited, possibly because the strength of the large-scale atmospheric flow decreases, the control exerted by the lateral boundary conditions is weaker, and the nested models are mainly governed by local processes. © Inter-Research 2011.

We investigated the short-term effects of particulate matter with aerodynamic diameter <10γg/m3 (PM10), sulfur dioxide (SO2), nitrogen dioxide (NO2) and ozone (O3) on pediatric asthma emergency admissions in Athens, Greece over the period 2001-2004. We explored effect modification patterns by season, sex, age and by the presence of desert dust transported mainly from the Sahara area.We used daily time-series data provided by the children's hospitals and the fixed monitoring stations. The associations were investigated using Poisson regression models controlling for seasonality, weather, influenza episodes, day of the week and holiday effects.A 10γg/m3 increase in PM10 was associated with a 2.54% increase (95% confidence interval (CI): 0.06%, 5.08%) in the number of pediatric asthma hospital admissions, while the same increase in SO2 was associated with a 5.98% (95% CI: 0.88%, 11.33%) increase. O3 was associated with a statistically significant increase in asthma admissions among older children in the summer. Our findings provide limited evidence of an association between NO2 exposure and asthma exacerbation. Statistically significant PM10 effects were higher during winter and during desert dust days, while SO2 effects occurred mainly during spring.Our study confirms previously reported PM10 effects on emergency hospital admissions for pediatric asthma and further provides evidence of stronger effects during desert dust days. We additionally report severe effects of SO2, even at today's low concentration levels. © 2011 Elsevier Inc.

Objectives: In some trials, particularly in oncology, patients whose disease progresses under the comparator treatment are crossed over into the experimental arm. This unplanned crossover can introduce bias in analyses because patients who crossover likely have a different prognosis than those who do not cross over; for instance, sicker patients not responding to standard therapy or those expected to benefit the most may be selectively chosen to receive the experimental treatment. Standard statistical methods cannot adequately correct for this bias. We describe an approach designed to minimize the impact of crossover, and illustrate this by using data from two randomized trials in multiple myeloma (MM). Methods: The MM-009/010 trials compared lenalidomide and high-dose dexamethasone (Len+Dex) with dexamethasone alone (Dex). Nearly half (47%) of the patients randomized to Dex crossed over to Len with or without Dex (Len+/-Dex) at disease progression or study unblinding. Data from these trials was used to predict survival in an economic model evaluating the cost-effectiveness of lenalidomide. To adjust for crossover, the prediction equations were calibrated to match survival with Dex or Dex-equivalent therapies in trials conducted by the Medical Research Council (MRC) in the United Kingdom. To adjust for differences between the MM and MRC trial populations, a prediction equation was developed from the MRC data and used to predict survival by setting predictors to mean values for patients in the MM-009/010 trials. The expected survival with Dex without crossover was then predicted from the calibrated MM-009/010 equation (i.e., adjusted to match survival predicted from the MRC equation). Results: The adjusted median overall survival predicted by the MRC equation was 19.5 months (95%CI, 16.622.9) for patients with one prior therapy, and 11.6 months (95% CI, 9.514.2) for patients with >1 prior therapy. These estimates are considerably shorter than was observed in the clinical trials: 33.6 months (27.1-NE) and 27.3 months (95% CI, 23.333.3) as of December 2005. Conclusion: The calibration method described here is simple to implement, provided that suitable data are available; it can be implemented with other types of endpoints in any therapeutic area. © 2011 International Society for Pharmacoeconomics and Outcomes Research (ISPOR).

Adolescent gynaecology is increasingly recognized as an area in which specific knowledge and expertise is required to ensure that patients achieve the best outcome. Gynaecological problems in adolescents are common, and although serious pathology is rare, distress and discomfort can be significant. Adolescent girls are under greater pressure than ever before, particularly in terms of examination performance; they find menstrual dysfunction particularly difficult to manage. Careful and sympathetic assessment is crucial, and simple treatment remedies may be all that is required. However, complex and rare medical conditions can also occur and must not be missed. Some congenital disorders present for the first time in adolescence. Early detection and appropriate treatment will ensure the best possible outcomes in terms of sexual function and potential fertility. © 2011 Elsevier Ltd.

The Amvrakia spring is located at the bottom of Meteora pillars and more specifically near the village of Kastraki (Kalambaka municipality). It is a seasonal spring since it functions only during the wet period. The Meteora conglomerates which dominate the area are characterized by large discontinuities creating a network of groundwater pathways above the impermeable strata of the underlying marls. The research targets was to define these water pathways in order to understand the mechanism of Amvrakia spring, by mapping the exposed discontinuity network and define their underground extension with the contribution of geophysical techniques. Electrical Resistivity Tomography (ERT) and Very Low Frequency (VLF) methodologies were applied. The VLF method is indicated for the detection of water-bearing fracture zones, but before the application of their filters they had to be processed for topographic corrections, as the area had not smooth relief. Five (5) VLF profiles were conducted with different directions around the spring’s area, in order to detect possible conductive zones in the conglomerates surrounding the study area. Moreover, two (2) ERT sections of a total length of 140m were carried out, parallel to existent VLF sections, for crosschecking the geophysical information. Both techniques revealed important conductive zones (<200 Ohm.m) from the south-eastern Meteora conglomerate pillars, possibly interpreted as discontinuities filled with water feeding the spring.

Osteolytic disease is a major complication of multiple myeloma that may lead to devastating skeletal-related events (SREs). Conventional radiography remains the gold standard for the evaluation of bone disease in patients with myeloma. However, whole-body magnetic resonance imaging (MRI) is recommended in patients with normal conventional radiography and should be performed as part of staging in all patients with a solitary plasmacytoma of bone. Urgent MRI is also the diagnostic procedure of choice to assess suspected cord compression, whereas computed tomography can guide tissue biopsy. Positron emission tomography with computed tomography can provide complementary information to MRI, but its use in multiple myeloma must be better defined by further studies. The incorporation of abnormal MRI findings into the definition of symptomatic myeloma also needs to be clarified. Bisphosphonates remain the cornerstone for the management of myeloma bone disease. Intravenous pamidronate and zoledronic acid are equally effective in reducing SREs, whereas zoledronic acid seems to offer survival benefits in symptomatic patients. Caution is needed to avoid adverse events, such as renal impairment and osteonecrosis of the jaw. Novel antiresorptive agents, such as denosumab, have given encouraging results, but further studies are needed before their approval for managing myeloma bone disease. Combination approaches with novel antimyeloma agents, such as bortezomib (which has anabolic effects on bone) with bisphosphonates or with drugs that enhance osteoblast function, such as antidickkopf-1 agents, antisclerostin drugs, or sotatercept, may favorably alter our way of managing myeloma bone disease in the near future. © 2011 by American Society of Clinical Oncology.

8-Oxo-7,8-dihydroguanine (8-oxoG) accumulates in the genome over time and is believed to contribute to the development of aging characteristics of skeletal muscle and various aging-related diseases. Here, we show a significantly increased level of intrahelical 8-oxoG and 8-oxoguanine-DNA glycosylase (OGG1) expression in aged human skeletal muscle compared to that of young individuals. In response to exercise, the 8-oxoG level was lastingly elevated in sedentary young and old subjects, but returned rapidly to preexercise levels in the DNA of physically active individuals independent of age. 8-OxoG levels in DNA were inversely correlated with the abundance of acetylated OGG1 (Ac-OGG1), but not with total OGG1, apurinic/apyrimidinic endonuclease 1 (APE1), or Ac-APE1. The actual Ac-OGG1 level was linked to exercise-induced oxidative stress, as shown by changes in lipid peroxide levels and expression of Cu,Zn-SOD, Mn-SOD, and SIRT3, as well as the balance between acetyltransferase p300/CBP and deacetylase SIRT1, but not SIRT6 expression. Together these data suggest that that acetylated form of OGG1, and not OGG1 itself, correlates inversely with the 8-oxoG level in the DNA of human skeletal muscle, and the Ac-OGG1 level is dependent on adaptive cellular responses to physical activity, but is age independent.

Surface air temperature trends in the wider region of Greece during the period 1951-2007, related to atmospheric circulation, are examined in this work. A network of 31 meteorological stations in the Hellenic area and the Asia Minor coasts and National Centers for Environmental Prediction/National Center for Atmospheric Research (NCEP/NCAR) reanalysis datasets were used for this purpose. The NCEP/NCAR reanalysis datasets were created by assimilating climate observations from different sources including ships, satellites, ground stations, radiosonde observations and radar. The general purpose of conducting the reanalyses was to produce multiyear global state-of-the-art gridded representations of atmospheric states, generated by a constant model and a constant data assimilation system. The findings of the analysis show that the mean annual surface air temperature in the wider region of Greece exhibits a pronounced cooling trend from the beginning of the 1950s up to the mid-1970s. It then remained at low levels until the beginning of the 1990s, and then increased up to 2000, when a turning-point is clear although the temperature remained at high levels. The well-known atmospheric circulation indices of the wider region of Europe, namely the North Atlantic Oscillation Index (NAOI), the Mediterranean Oscillation Index (MOI) and the North Sea Caspian Pattern Index (NCPI), were used to investigate the relationship between surface air temperature and atmospheric circulation in this region of the Eastern Mediterranean. The surface air temperature is not correlated to the NAOI, while it is statistically significantly (95% confidence level (CL)) correlated to the MOI, but only during wintertime. On the contrary, good correlations, which are statistically significant (95% CL), appear between the NCPI and the surface air temperature during all seasons, but particularly in winter. © 2011 Taylor & Francis.

The purpose of this study was to identify, categorize, and analyze published process-product research on physical education teaching methods completed between1960 and 2009. A literature search utilizing electronic databases yielded 138 studies which met the criteria for inclusion in the analysis. Each study was analyzed to obtain information on (a) the decade the study was published, (b) the number of authors, (c) the publication outlet, (d) the type of class, (e) the sampling method, (f) the effect size, (g) the statistics used, and (h) the statistical assumptions. The results indicated that most studies were the result of collaboration efforts among researchers. Also, intact classes rather than randomization were the most common technique used for forming the experimental groups. In the majority of the studies, the selection of the sample was done by means of purposive sampling techniques. A large proportion of the studies used univariate statistics to complete the data analysis.  However, the majority of the papers reviewed did not report effect size values nor did they report fulfillment of certain statistical assumptions.  The major publication outlet for process-product research was the Journal of Teaching in Physical Education.

To describe the tourism potential of an area, not only single meteorological parameters have to be taken into account, but also thermal sensation and people's thermal comfort. The latter can be estimated by the use of human energy balance models and the derived thermal indices, which comprise all relevant meteorological parameters like air temperature, air humidity, wind speed, and short and long wave radiation fluxes. This paper makes an attempt to assess and analyze climatological parameters and the thermal comfort of Crete, its variations and trends for the period of time 1955-2001. In addition, a definition and quantification of the island's tourism potential is carried out. Long term data from several stations are used from the existing climatic and synoptic network of Crete, including daily mean, maximum and minimum temperature, relative humidity, wind speed, and cloud cover over the whole island, in order to derive the daily Physiologically Equivalent Temperature (PET) and precipitation. In addition, possible trends of thermal comfort and precipitation on an annual and seasonal basis are analyzed. Additionally, data of the 10-minutes climatology of the Climate Research Unit of the University of Norwich have been processed in order to create high resolution (1 km) mean monthly maps for climatological parameters such as air temperature, precipitation and Physiologically Equivalent Temperature. © 2011 Global NEST Printed in Greece. All rights reserved.

In previous papers ([1, 2]) we defined the C*-algebra and the longitudinal pseudodifferential calculus of any singular foliation (M,). In the current paper we construct the analytic index of an elliptic operator as a KK-theory element, and prove that this element can be obtained from an “adiabatic foliation”  on M×ℝ, which we introduce here.

Measurements of clitoral length and clitoral to urethral distance were made and analysed for a relationship in a group of 19 women with complete androgen insensitivity syndrome (CAIS) attending a specialist clinic for adult women with disorders of sexual development. These were compared with a control group of 50 women attending hospital for a gynaecological procedure. There was a positive correlation between clitoral length and clitoral to urethral distance for women with CAIS. In contrast, a negative correlation was seen between clitoral length and clitoral to urethral distance for women in the control group. Women with CAIS had a reduced mean clitoral length compared with controls (P = 0.001), but no difference was observed for the clitoral to urethral distance between the two groups (P = 0.116). © RCOG 2010 BJOG An International Journal of Obstetrics and Gynaecology.

The susceptibilities of 824 Bacteroides fragilis group isolates against nine antibiotics were evaluated in a Europe-wide study involving 13 countries. Species determination, by different methods, was carried out on all but one isolate. Resistance rates were evaluated according to species and geographical areas via CLSI and the European Committee on Antimicrobial Susceptibility Testing (EUCAST) breakpoints. The present data were compared with those obtained 10 and 20 years ago at a European level. High-level resistance (MIC ≥ 64 mg/L) to ampicillin was observed in 44.5% of the strains, which is a significant increase relative to 20 years ago (16%). Piperacillin/tazobactam was more active than amoxicillin/clavulanic acid (3.1% and 10.4% resistance, respectively), again with a resistance increase relative to earlier studies. Dramatic increases in resistance were observed for cefoxitin, clindamycin and moxifloxacin, with rates of 17.2%, 32.4% and 13.6%, respectively. The lowest resistances were found for imipenem, metronidazole and tigecycline (1.2%, <1% and 1.7%). Nonsusceptible strains to imipenem and metronidazole were more resistant to other anti-anaerobic drugs. Differences were detected between geographical areas, with higher resistance rates for moxifloxacin in Scandinavian countries (21.4%) than in Mediterranean countries (5.4%), whereas, for clindamycin, the resistance rates were higher in Mediterranean (41.8%) and lower in Scandinavian countries (22.5%). Piperacillin/tazobactam resistance was also higher in Scandinavian countries.

Background: We have showed that secretory Apolipoprotein J/Clusterin (sCLU) is down-regulated in senescent, stressed or diseased red blood cells (RBCs). It was hypothesized that sCLU loss relates to RBCs vesiculation, a mechanism that removes erythrocyte membrane patches containing defective or potentially harmful components. Methodology/Principal Findings: To investigate this issue we employed a combination of biochemical and microscopical approaches in freshly prepared RBCs or RBCs stored under standard blood bank conditions, an in vitro model system of cellular aging. We found that sCLU is effectively exocytosed in vivo during membrane vesiculation of freshly prepared RBCs. In support, the RBCs' sCLU content was progressively reduced during RBCs ex vivo maturation and senescence under cold storage due to its selective exocytosis in membrane vesicles. A range of typical vesicular components, also involved in RBCs senescence, like Band 3, CD59, hemoglobin and carbonylated membrane proteins were found to physically interact with sCLU. Conclusions/Significance: The maturation of RBCs is associated with a progressive loss of sCLU. We propose that sCLU is functionally involved in the disposal of oxidized/defected material through RBCs vesiculation. This process most probably takes place through sCLU interaction with RBCs membrane proteins that are implicit vesicular components. Therefore, sCLU represents a pro-survival factor acting for the postponement of the untimely clearance of RBCs. © 2011 Antonelou et al.

Resumen: Cecilia Valdés o La Loma del Ángel y Martín Rivas son novelas clásicas de la literatura hispanoamericana. Ambas presentan la estratificación social y las ideas de unas épocas concretas. En Cecilia Valdés se presenta el mosaico de la sociedad cubana en la primera mitad del siglo XIX. Los personajes blancos son la capa dominante mientras las otras capas se preocupan más por su sobrevivencia. Los personajes blancos ricos están a favor de la esclavitud. Igualmente consideran el concubinato como algo normal y aceptable. Los personajes jóvenes ricos siguen las ideas de los mayores y se comportan del mismo modo. Los personajes femeninos tienen un papel secundario y aunque son más compasivas hacia los esclavos no pueden hacer algo. En Martín Rivas, a través de la descripción de los personajes, se revela el modo de pensar de dos capas principales: “las buenas familias” y el “medio pelo”. Los personajes de la burguesía adinerada son conservadores y se interesan en la vida política motivados siempre por su interés económico y su anhelo de poder. Los personajes femeninos, sumisos al poder masculino, no tienen ninguna participación política aunque a veces expresan opiniones contrarias a las de los hombres. Al contrario los personajes jóvenes de la burguesía pobre se inclinan al liberalismo de manera espontánea.   Palabras clave: novela, hispanoamericana, romanticismo, realismo, esclavitud, ideología, sociedad, dinero.

A comparison of two objective climatologies of explosive cyclones in the Mediterranean region is performed. The results are derived from two different mean sea-level pressure reanalysis data resolutions, but from the same assimilation model, in order to quantify the pure impact of higher resolution on the identification and characteristics of explosive cyclones, when the assimilation model is the same. The explosive cyclones were identified with the aid of the Melbourne University automatic cyclone finding and tracking scheme over a 40-year period, using the 6-hourly analyses of ERA-40 mean sea-level pressure (MSLP) on: (a) 2.5 × 2.5 and (b) 1 × 1 latitude-longitude grid. The comparison of the two datasets revealed the significant role of the increase in spatial resolution of MSLP data on the identification and tracking process, and the number of the explosive cyclones in the high-resolution dataset is almost four times greater than the respective one in the lower resolution dataset. However, the comparison of explosive cyclone characteristics, including spatial and temporal variations of explosive deepening, revealed differences in the geographical distribution of the location of the maximum explosive deepening and average explosive cyclone Laplacian of the central pressure. These differences are due to the identification in the higher resolution set of smaller scale and secondary explosives along the strongly baroclinic northern Mediterranean boundaries, south of the Alps and the Pyrenees. Explosive deepening appears a bias to the daytime period from 12 to 18 Coordinated Universal Time (UTC) for both datasets, which is more prominent in the LR dataset. Statistically significant difference of pressure tendency between the two datasets appear for the daytime period from 06 to 12 UTC, accounting for better representation of orographic forcing in the HR dataset. © 2011 Springer-Verlag.

The potential genotoxic effects of several pure secondary metabolites produced by fungi used as biological control agents (BCAs) were studied with the Ames Salmonella/microsome mutagenicity assay and the Vitotox test, with and without metabolic activation. A complete set of Salmonella tester strains was used to avoid false negative results. To detect possible mutagenic and/or cytotoxic effects of fungal secondary metabolites due to synergistic action, crude extracts and fungal cell extracts of the BCAs were also examined. Although the sensitivity of the methods varied depending on the metabolite used, clearly no genotoxicity was observed in all cases. The results of the two assays are discussed in the light of being used in a complementary fashion for a convincing risk-assessment evaluation of fungal BCAs and their secondary metabolites.

The use of integrated Hospital Information Systems is related with many benefits for the healthcare system, increasing the effectiveness of the provided services and assuring quality of care. Aim of this study is to investigate the types of Information Systems, the level of integration and the problems identified during the implementation phase, in three public hospitals. The above are expected to contribute to the understanding of the organizational, human resource and technical factors related with the successful implementation of a hospital IS. In order to investigate those elements, an assessment questionnaire was developed and completed by nine hospitals IT employees of the three hospitals. In addition, open interviews were organized with the same employees to further formulate an overall aspect, while in one hospital case, observation and discussion with four different categories of involved staff was undertaken. It was found that the implementation problems are mainly related with the underfunding, inadequate use of standards, lack of skilled IT experts, insufficiently trained personnel and users' reserve. The problems may be tackled with a supportive hospital administration committed to the successful implementation. The external contracting company working on its own, without any participation of the hospital IT department seems to be a failure recipe. It is evident that an active management support and skillful hospital IT employees, are expected to result to success stories during the implementation of integrated hospital information systems.

This paper examines the collaborative-intergenerational efforts, conflict resolution curricula, projects and training activities of non-profit organizations and NGOs— that reflect the values of Olympism—striving to eliminate racism and xenophobia as well as promote gender equity in sports. In this transitional stage of the postmodernist period, practices of social exclusion or under-representation due to gender, race, class, religion, sexual orientation, and so forth are socially problematic and theoretically inconsistent. The promotion of new role models and mentors in sports is vital in view of the systematic misinterpretation, or rather, misuse of Olympic values, such as obsessive competitiveness and the increase of violence and racism linked to sport events. Moreover, focusing on commercialization and consumerism are notincentives that reactivate Olympic values. A critical issue addressed, among others, is the democratization of the IOC structures. This paper argues that Peace Education—Olympism adapted into today’s globalized world—be incorporated into future reforms, educational policies and teaching practices in order to raise awareness concerning the core values of peace: pro-social attitudes, reducing ethnic prejudices, respect for diversity, promoting reconciliation, gender equality, non-violent conflict resolution and democratic decision-making.Keywords: peace education-conflict resolution skills, Olympism, racism, xenophobia, gender equity, glass ceiling, glass escalator, tokenism.I---------------------------------------------------------------------------------------------------------------Second version, entire journal attached: pages 141-156 Kamberidou, Irene (2011). Athlete Activism and Peace Education: Bridging the Social Inequality Gap through Sports.  NEBULA A Journal of Multidisciplinary Scholarship, Volume 8, Issue 1, December 2011. Online Quarterly Academic Periodical. ISSN – 1449-7751 [First online version: 168-180]

second version, entire journal attached: pages 141-156 Kamberidou, Irene (2011). Athlete Activism and Peace Education: Bridging the Social Inequality Gap through Sports.  NEBULA A Journal of Multidisciplinary Scholarship, Volume 8, Issue 1, pp. 141-156, December 2011. Online Quarterly Academic Periodical. ISSN – 1449-7751

Kamberidou, I. (2011). “Athletes United for Peace: Reconciliation through Sport.” Presentation (εισήγηση) at the international conference SPORT AS A MEDIATOR BETWEEN CULTURES, September 15-17, 2011, Wingate Institute/Zinman College, Israel.  The International  Council of Sport Science and Physical Education(ICSSPE/CIEPSS). http://www.icsspe.org/index_1068a88f.php.html [book of abstracts, also see powerpoint presentation in http://www.icsspe.org/documente/Irene_Kamberidou_-_Athletes_United_for_Peace.pdf

1.        D. 4.1, D.4.1.1 and  D.4.2 in Apella

Coaxial resonant cavities with longitudinal corrugations on the inner conductor are used in high-frequency high-power gyrotrons as means to reduce the number of possible competing modes. For a sufficiently large number of corrugations, the analytical approach usually treats the surface corrugation as a homogeneous surface impedance to obtain simple formulas for the characteristic equation and field components. These formulas can be introduced to interaction codes in a quite straightforward way. Full-wave approaches that account for the azimuthal periodicity of the structure and consider azimuthal spatial harmonics to describe the field distributions have been also employed, increasing though the complexity of the solution and the effort given in numerical calculations. In this paper, a full-wave code is used in an attempt to identify the way that the azimuthal spatial terms contribute to the reformation of the eigenvalue spectrum and propose a criterion for the selection of the spatial terms that should be taken into account for accurate enough calculations.

Hospital institution's managers are called upon to combine and utilize efficiently the finite financial resources toward the goal of maximizing the number and quality of health services offered. The research aim of this study is to primarily estimate the relative technical efficiency by using a sample from public hospital units that provide obstetrical and gynaecological services in Greece and secondly, to emphasize the policy implications for health sector policy-makers. In order to effectively address the above goals, a comparative analysis of 32 Greek Public Hospital Units was conducted. The research was based on data collected from official public sources. Quantitative analysis, specifically data envelopment analysis (DEA) is used to estimate efficiency of hospital units. Based on the results that emerge from the application of Data Envelopment Analysis, information is provided to their managers, which refer to: (i) the degree of utilization of their production factors, (ii) the particular weight of each production factor in the modulation of the relative technical efficiency score, (iii) the utilization level of each production factor, and (iv) those hospital units that utilize their resources in an optimal way and constitute models for the exercising of effective management. Particular emphasis is given to the economic efficiency of central region hospital units' relative to those of the outlying regions. The derived information assists in the modulation of an appropriate policy mix per hospital unit which should be applied by their management teams along with a set of administrative measures that need to be undertaken in order to promote efficiency. © 2011 by Nova Science Publishers, Inc. All rights reserved.

BACKGROUND: Biomedical informatics is a broad discipline that borrows many methods and techniques from other disciplines. OBJECTIVE: To reflect a) on the character of biomedical informatics and to determine whether it is multi-disciplinary or inter-disciplinary; b) on the question whether biomedical informatics is more than the sum of its supporting disciplines and c) on the position of biomedical informatics with respect to related disciplines. METHOD: Inviting an international group of experts in biomedical informatics and related disciplines on the occasion of the 50th anniversary of Methods of Information in Medicine to present their viewpoints. RESULTS AND CONCLUSIONS: This paper contains the reflections of a number of the invited experts on the character of biomedical informatics. Most of the authors agree that biomedical informatics is an interdisciplinary field of study where researchers with different scientific backgrounds alone or in combination carry out research. Biomedical informatics is a very broad scientific field and still expanding, yet comprised of a constructive aspect (designing and building systems). One author expressed that the essence of biomedical informatics, as opposed to related disciplines, lies in the modelling of the biomedical content. Interdisciplinarity also has consequences for education. Maintaining rigid disciplinary structures does not allow for sufficient adaptability to capitalize on important trends nor to leverage the influences these trends may have on biomedical informatics. It is therefore important for students to become aware of research findings in related disciplines. In this respect, it was also noted that the fact that many scientific fields use different languages and that the research findings are stored in separate bibliographic databases makes it possible that potentially connected findings will never be linked, despite the fact that these findings were published. Bridges between the sciences are needed for the success of biomedical informatics.

Pompe disease is an inherited metabolic disorder caused by α-glycosidase deficiency. The adult onset form is mainly characterized by progressive proximal muscle weakness and respiratory dysfunction. The aim of the present study is to evaluate body composition in adult patients before and after enzyme replacement therapy (ERT). Body composition was examined at baseline by means of dual x-ray absorptiometry (DXA) in nine adult patients and after different time periods in six of them who received ERT. Total BMD (bone mineral density) was initially mildly decreased in two patients, while femoral neck BMD was decreased in five patients. On the other hand fat mass was increased in the majority of patients, while body mass index (BMI) was high in four. ERT administration did not seem to induce obvious BMD changes in any patient. Conclusively, the greater femoral neck BMD involvement may be attributed to the lower mechanical load applied by the selectively weakened muscles, whereas the increased fat mass may be the result of metabolic and nutritional derangement.

Reece et al report that single-agent bortezomib resulted in hematologic responses in two-thirds of patients with relapsed Light chain (AL) amyloidosis, including complete responses in one-third, while more than 75% of patients had response duration of more than or equal to 1 year.

This paper investigates calendar anomalies for four emerging stock markets (Romania,Bulgaria, Croatia and Turkey) and their mature counterpart in the Balkan region (Greece), during the period 2000-2008. Five well known calendar effects on both return and volatility are examined; the day of the week effect, the January effect, the half month effect, the turn of the month effect and the time of the month effect. We provide evidence for the existence of three calendar effects (day of the week, turn of the month, time of the month) in both mean and volatility equations for Greece and Turkey, which is consistent to the findings of previous studies. On the other hand, the effects for the three emerging Balkan markets are limited and exist only in volatility. This contradictory evidence could be due to a different level of liquidity and maturity for these markets.

Contemporary thinking seems to be particularly interested in the investigation of the role of culture in socio-political life. This article presents aspects of a research project, undertaken in Greece, looking into whether a cultural product can foster intercultural communication and influence young people’s perceptions of and attitudes to cultural and religious diversity. Such cultural products are the Theatre in Education (TiE) programmes, which focus on the use of the art of theatre as a means of educational intervention. For the purposes of our research a specially designed TiE programme was used as a means of intervention and as are search tool. Our research examines secondary education students’ perceptions of and attitudes to cultural and religious diversity prior to and following the intervention in Thessaloniki and in Thrace, Greece. This cultural intervention, which incorporates art and religion, offers new insights into the possibility of the use of TiE for the religious education of young people.

Electroconvulsive therapy (ECT) is an effective treatment and, with the proper risk-minimizing strategies, is relatively safe even in depressed patients with cardiovascular diseases. Specifically, patients with cardiac rhythm management devices (CRMDs) require particular attention because no controlled trials exist to support current empirical recommendations. We present a depressed patient with a pacemaker successfully treated with ECT, and we critically review the relevant literature. Pooled results from 63 patients and 821 ECT sessions showed that 90% of ECT sessions have been performed on depressed patients with their pacemakers in sensing mode and rate adaptation, where available, activated as well. Only 4% of sessions were performed with those functions disabled, whereas no data was available for 6% of ECT sessions. Pooled results from case series and reports highlight a discrepancy between current clinical practice and many guidelines. Electroconvulsive therapy is probably safe in depressed patients with asynchronous fixed-rate pacemakers, although there is a risk of ventricular tachycardia and fibrillation. A larger body of case series and reports suggests that there might be no need to convert synchronous demand pacemakers to asynchronous fixed-rate pacing. Regarding patients with implantable cardioverter defibrillators, antitachycardia treatment was deactivated during most ECT sessions. In depressed patients with CRMDs anticholinergics might be best avoided. In all cases, proper ECT procedures, namely, patient and pacemaker electrical isolation, strict grounding and adequate muscle relaxation along with interrogation and monitoring of CRMDs before and after each session should ensure uncomplicated electroconvulsive treatments.

Case matching effects involve situations where a nominal element appears in a case that is not predicted by its syntactic status in its clause, but rather matches the case requirements of an external element. Such constructions pose serious problems for syntactic accounts of case in terms of a syntactic Case feature, because they involve a situation of case conflict/mismatch. In this article, I address the issue of case assignment/realization by examining case attraction phenomena in Greek free relative clauses. In particular, I suggest an analysis that builds on the idea that case categories are not primitives, but rather they can be decomposed in bundles of features and I propose a division of labour between narrow syntax and Morphological Structure as far as case assignment/realization is concerned. Case assignment takes place in narrow syntax as a licensing device (abstract case), but it refers only to those features that are relevant to the distinction between structural and inherent case. The full specification of the case feature bundle takes place in the Morphological Structure as a result of the application of specific case assignment algorithms defined in terms of case domains and hierarchies. At a theoretical level, such a hypothesis has the benefit of incorporating the insights about the role of case determination at Morphological Structure, as well as maintaining the well-established notion of abstract case as a licensing device of narrow syntax.

The increased operational tempo associated with current deployments to Operation Iraqi Freedom (OIF) and Operation Enduring Freedom (OEF) is placing considerable strain on military families. Among other sequelae of OIF and OEF deployment, findings from recent studies suggest high rates of depression in spouses of service members. This review presents a rationale for targeting depression among military spouses. It examines how stressors relating to the deployment cycle may contribute to depression in spouses and outlines the effects of spousal depression on the mental health of service members and their children. Mental health services currently available to military spouses as well as barriers to their care are also described. Considerations for the adaptation of treatment to their unique circumstances and needs are discussed. (PsycINFO Database Record (c) 2011 APA, all rights reserved).

The optional use of morphology attested in second language learners has been attributed either to a representational deficit or to a ‘surface’ problem with respect to the realization of inflectional affixes. In this article we contribute to this issue by providing empirical data from the early interlanguage of Greek learners of Turkish. Three experiments have been conducted, a cloze task, a sentence picture matching task and an on-line grammaticality judgement task, in order to investigate case morphology and its interaction with word order constraints.The findings of all three experiments point towards a variable use of case morphology, which is also observed in previous studies of Turkish as a second language (L2). Moreover, they show clearly that the learners face difficulties with non-canonical word orders as well as with the interaction of word order constraints and Case. On the other hand, the learners performed well on verbal inflections. On the basis of these findings, we argue that the developmental patterns in the early stages of L2 acquisition cannot be attributed to a global lack of functional categories but rather to more localized difficulties, which seem to be related to (a) whether the features in the L2 are grammaticalized in the first language and (b) the way these features are encoded in the morphosyntax of the first language. Moreover, we claim that processing factors and the specific properties of the morphological paradigms affect L2 development.

E-cadherin (CDH1) loss occurs frequently in carcinogenesis, contributing to invasion and metastasis. We observed that mouse and human epithelial cell lines overexpressing the replication licensing factor Cdc6 underwent phenotypic changes with mesenchymal features and loss of E-cadherin. Analysis in various types of human cancer revealed a strong correlation between increased Cdc6 expression and reduced E-cadherin levels. Prompted by these findings, we discovered that Cdc6 repressed CDH1 transcription by binding to the E-boxes of its promoter, leading to dissociation of the chromosomal insulator CTCF, displacement of the histone variant H2A.Z, and promoter heterochromatinization. Mutational analysis identified the Walker B motif and C-terminal region of Cdc6 as essential for CDH1 transcriptional suppression. Strikingly, CTCF displacement resulted in activation of adjacent origins of replication. These data demonstrate that Cdc6 acts as a molecular switch at the E-cadherin locus, linking transcriptional repression to activation of replication, and provide a telling example of how replication licensing factors could usurp alternative programs to fulfill distinct cellular functions.

The aim of the present study was to evaluate the levels of homocysteine and 8-iso PGF 2a in football and hockey players before and soon after a match, on the predisposition for development of atherosclerosis. We measured 8-iso-PGF 2a and homocysteine in 21 football athletes aged 21.8 ± 3.7 years old and 18 hockey athletes 22.2 ± 3.3 years old, respectively. All the athletes presented significant increases in serum homocysteine levels following the match (p = 0.001 for football and p = 0.001 for hockey players) Also a statistically significant increase of 8-iso-PGF 2a levels was found in hockey and football athletes following the match (p < 0.001 and p = 0.071). Our findings suggest that strenuous exercise such as a football or a hockey match causes a marked increase in serum homocysteine and 8-iso-PGF 2a. Due to the fact that homocysteine and 8-iso-PGF 2a are contributing to atheromatosis, it may be useful to follow a restoration exercise program that involves mild exercise and to pay special attention to folate, vitamin B6, and vitamin B12 balance during the first 24 h after the match. Copyright © Taylor & Francis Group, LLC.

The aim of the present study was to evaluate the levels of homocysteine and 8-iso PGF2a in football and hockey players before and soon after a match, on the predisposition for development of atherosclerosis. We measured 8-iso-PGF2a and homocysteine in 21 football athletes aged 21.8 ± 3.7 years old and 18 hockey athletes 22.2 ± 3.3 years old, respectively. All the athletes presented significant increases in serum homocysteine levels following the match (p = 0.001 for football and p = 0.001 for hockey players) Also a statistically significant increase of 8-iso-PGF 2a levels was found in hockey and football athletes following the match (p < 0.001 and p = 0.071). Our findings suggest that strenuous exercise such as a football or a hockey match causes a marked increase in serum homocysteine and 8-iso-PGF2a. Due to the fact that homocysteine and 8-iso-PGF2a are contributing to atheromatosis, it may be useful to follow a restoration exercise program that involves mild exercise and to pay special attention to folate, vitamin B6, and vitamin B12 balance during the first 24 h after the match. Copyright © Taylor & Francis Group, LLC.

The aim of the present study was to evaluate the levels of homocysteine and 8-iso PGF2a in football and hockey players before and soon after a match, on the predisposition for development of atherosclerosis. We measured 8-iso-PGF2a and homocysteine in 21 football athletes aged 21.8 ± 3.7 years old and 18 hockey athletes 22.2 ± 3.3 years old, respectively. All the athletes presented significant increases in serum homocysteine levels following the match (p = 0.001 for football and p = 0.001 for hockey players) Also a statistically significant increase of 8-iso-PGF 2a levels was found in hockey and football athletes following the match (p < 0.001 and p = 0.071). Our findings suggest that strenuous exercise such as a football or a hockey match causes a marked increase in serum homocysteine and 8-iso-PGF2a. Due to the fact that homocysteine and 8-iso-PGF2a are contributing to atheromatosis, it may be useful to follow a restoration exercise program that involves mild exercise and to pay special attention to folate, vitamin B6, and vitamin B12 balance during the first 24 h after the match. Copyright © Taylor & Francis Group, LLC.

Although haematological toxicities, such as anaemia, are common in multiple myeloma (MM), no clear consensus exists on the use and impact of erythropoiesis-stimulating agents (ESA) on outcomes in MM. This analysis characterizes haematological toxicities and associated interventions in the phase III VISTA (Velcade ® as Initial Standard Therapy in Multiple Myeloma: Assessment with Melphalan and Prednisone) study of bortezomib plus melphalan/prednisone (VMP, n=344) versus MP (n=338) in previously untreated MM patients ineligible for high-dose therapy, and evaluates the impact of ESA use or red-blood-cell (RBC) transfusions on outcomes and thromboembolic risk. Incidence of haematological toxicities was similar with VMP and MP; similar rates of interventions and associated complications (e.g. bleeding, febrile neutropenia) were observed. Two hundred thirty three patients received ESA; 204 had RBC transfusions. Frequency of thromboembolic events was low and not affected by ESA use. Median time-to progression (TTP) was similar between ESA/non-ESA [hazard ratio: 1·03 (95% confidence interval 0·76-1·39); P=0·8478] in both arms (VMP: 19·9/not reached; MP: 15·0/17·5months). Three-year overall survival (OS) rates were similar between ESA/non-ESA in each arm. Patients receiving RBC transfusions had significantly shorter OS (P<0·0001) versus non-RBC-transfusion patients. In conclusion, bortezomib did not add to melphalan haematological toxicity. Concomitant ESA use with VMP/MP in previously untreated MM patients did not adversely affect TTP or OS, or increase thromboembolic risk. However, RBC transfusion was associated with significantly shorter survival. © 2011 Blackwell Publishing Ltd.

Mastic water is a commercial flavouring obtained during the steam distillation of mastic resin (the resin of Pistacia lentiscus var. chia) for the production of mastic oil. The mastic water extracts were analysed by GC-MS. The major compounds identified were verbenone, α-terpineol, linalool and trans-pinocarveol. Overall the composition was found to be very different from that of mastic oil. Additional GC-MS revealed the enantiomeric ratio of the chiral constituents of mastic water. The antimicrobial activity of mastic water extract, as well as that of its major constituents, was examined against Escherichia coli, Staphylococcus aureus and Candida spp. including ATCC wild clinical and food-borne strains. Linalool and α-terpineol were found to be the most potent antimicrobial constituents. Finally the stability of mastic water at different temperatures was studied, showing no change in the GC-MS profile of the organic extract for a period of 4 months at storage temperatures up to 4 °C. © 2011 Elsevier Ltd. All rights reserved.

Acute urticaria (AU) is a common condition that often presents in childhood. Although there is a general perception of cyclic annual trends in AU, no one has tried to identify any seasonal variation on its prevalence and incidence, associate environmental influences and impute geographic, ethnic, or even genetic features that may contribute to its onset. We aimed to analyze the influence of climate and geographic parameters on annual fluctuation of AU cases referred to the Emergency Departments (EDs) of Norwich (UK) and Heraklion (Crete, Greece), compare all identifiable potential triggers and severity, and calculate the prevalence and incidence of AU. Record-based data of all children up to 14 yr of age referred to both EDs between June 2005 and May 2007 were examined retrospectively. Demographic characteristics and any potential identifiable triggers of AU were recorded and compared. Poisson's regression was utilized to examine any influence of meteorological parameters on AU incidence. Edwards' test for seasonality was applied to identify any significant seasonal trend of the AU incidence within each city. Seven hundred and twenty-nine AU cases were identified (324 in Norwich and 405 in Heraklion), among 56,624 total referrals (28,931 and 27,693 cases, respectively). Respiratory infections were found to be the most commonly associated potential triggers of AU and food allergens the least. AU cases and incidence rates in both cities were equally distributed during the study period. A non-significant seasonal trend in AU incidence (October, April-May) was observed in Norwich, in contrast to a significant seasonal pattern (December, February-May) of AU in Heraklion. Temperature was inversely associated with AU incidence, while the statistically significant effect of relative humidity varied. Acute childhood urticaria shows a similar epidemiological pattern in northern and southern Europe regardless of the expected differences in genetic, geographic, and environmental background. Temperature and humidity are correlated with AU incidence. Seasonality of several acute respiratory viral infections, the most prominent associated trigger of AU, coincides with the observed AU seasonality, suggesting a potential linkage. However, this needs to be elucidated from larger epidemiological studies.

{The adipokine visfatin has been proposed to exert insulin-mimicking effects and to play a role in the development of metabolic syndrome. Preterm infants are at risk for the later development of insulin resistance and, possibly, for other components of metabolic syndrome. Dietary long-chain polyunsaturated fatty acids (LCPUFAs) during the perinatal period may reduce the risk of metabolic syndrome. The authors’ objective was to study the circulating concentrations of visfatin in preterm infants and to examine associations of visfatin with anthropometric measurements, metabolic indices, and dietary LCPUFAs. Serum visfatin concentrations were determined by enzyme-linked immunosorbent assay at mean (SD) 33.8 (11.7) days of life in 60 healthy preterm infants (gestational age, 32.7 [1.9] weeks) randomly assigned to be fed since birth either a formula containing LCPUFA (arachidonic and docosahexaenoic acid) (+LCPUFA group) or the same formula without LCPUFA (-LCPUFA group). Associations of visfatin with anthropometric parameters, serum glucose, insulin, homeostasis model assessment index of insulin resistance, blood lipids, and adiponectin levels were examined. Serum visfatin levels were significantly higher in the +LCPUFA than in the -LCPUFA group (P < .001) and correlated positively with body weight z score (β = 0.31

Disorders such as depression and anxiety exhibit strong sex differences in their prevalence and incidence, with women also differing from men in their response to antidepressants. Furthermore, receptors for corticotrophin releasing hormone (CRHR1) and arginine vasopressin receptor subtype 1b (AVPR1b) are known to contribute to the regulation of mood and anxiety. In the present study, we compared the anxiety profile and CRHR1 and AVPR1b expression levels in control Sprague-Dawley (SD) rats and rats of the SD-derived Flinders Sensitive Line (FSL), a genetic model of depression. Additionally, given the apparent sex differences in the therapeutic efficacy of antidepressants and because antidepressants are commonly used to treat comorbid anxiety and depressive symptoms, we assessed whether the anxiolytic effects of an antidepressant occur in a sex-dependent manner. Male and female FSL rats were treated with citalopram 10 mg/kg once daily for 14 days and were then tested in the open field and the elevated plus maze paradigms. Upon completion of the behavioural analysis, AVPR1b and CRHR1 expression levels were monitored in the hypothalamus and the prefrontal cortex (PFC) using Western blotting. According to our results, male FSL rats were more anxious than control SD rats, a difference abolished by citalopram treatment. Baseline anxiety levels were similar in female FSL and SD rats, and citalopram further reduced anxiety in female FSL rats. Importantly, whereas citalopram altered AVPR1b expression in the hypothalamus of male FSL rats, its actions on this parameter were restricted to the PFC in female FSL rats. In both sexes of FSL rats, citalopram did not alter CRHR1 expression in either the hypothalamus or PFC. Our results demonstrate that antidepressant treatment reduces anxiety levels in FSL rats of both sexes: the magnitude of treatment effect was related to the starting baseline level of anxiety and the antidepressant elicited sexually differentiated neurobiological responses in specific brain regions.

European Media provides a clear, concise account of the structures, dynamics and realities of the changing face of media in Europe. It offers a timely and illuminating appraisal of the issues surrounding the development of new media in Europe and explores debates about the role of the media in the formation of a European public sphere and a European identity.The book argues that Europe offers an ideal context for examining interactions between global, regional and national media processes and its individual chapters consider: the changing structure of the European media; the development of new media; the Europeanization of the media in the region; the challenges for the content; and audiences. Special emphasis is given to the transformation of political communication in Europe and the alleged emergence of a European public sphere and identity. European Media: Structures, Politics and Identity is an invaluable text for courses on media and international studies as well as courses dealing with European and national policy studies. It is also helpful to students, researchers and professionals in the media sector since it combines hard facts with theoretical insight.

An objective climatology of explosive cyclones is performed over a 40-year period (1962-2001), for the Mediterranean region with the aid of the Melbourne University automatic cyclone finding and tracking scheme. The major temporal and spatial characteristics of Mediterranean explosive cyclones are investigated, including frequency, movement, generation and dissipation, scale, depth, and intensity. It was verified that the explosive cyclogenesis in the Mediterranean is a rather rare phenomenon that occurs mainly from November to March. Explosive cyclones preferentially form along the northern Mediterranean coast, with maximum density in the Ligurian and Aegean Seas. The cyclogenesis mechanism that predominates in their development is characterized by an interaction of a short and an open long wave in a pre-existing development (referred to as the KF mechanism). There are distinct differences between Western Mediterranean and Eastern Mediterranean explosive cyclones. Although explosive cyclones tend to form in the Western Mediterranean, their scale and depth is greater in the Eastern Mediterranean. Explosive cyclones more likely move from the main cyclogenetic areas in the Western Mediterranean along specific eastward paths over southern Italy and the Ionian Sea where they dissipate or they generate in Eastern Mediterranean and move north-eastwards to the Black Sea or eastwards to Cyprus and Middle East. © 2010 Royal Meteorological Society.

The paper studies the climatology of the Discomfort Index (DI) and the Common Air Quality Index (CAQI) in a large Mediterranean urban center (Greater Thessaloniki Area), examines the relations between the indices and the climatic conditions in the study area and investigates the linkage between the Urban Heat Island (UHI) effect and the enhanced discomfort and poor air quality in the city center. Discomfort conditions are more enhanced during July and August. Atmospheric conditions when the population suffers discomfort and feels severe stress are found mainly in the summer season hours with total frequency that can be up to about 4% in a month. Throughout the year, air quality conditions are unhealthier in the stations of urban characterization. Very high daily CAQI values are more frequent during the cold period (about 14%) than during the warm period (1-2%) of the year in the urban stations. Daily DI∈≥24°C could be more associated to increased temperature than relative humidity and is strongly related to high and very high CAQI values. During summer, when daily CAQI is ≥76, the feeling of discomfort is the most probable. Consequently, a strong synergy between discomfort and bad air quality exists in summertime. High and very high CAQI values and the discomfort feeling by the majority of the population are related to stagnant atmospheric conditions. During summer season, the poor air quality and the unfavorable comfort conditions for the majority of the population in the city center are associated with the greater frequency of a more intense UHI effect. The above phenomenon is more pronounced during nighttime than daytime. © 2011 Springer Science+Business Media B.V.

Objective To assess clinical characteristics and expectations in well women requesting elective labial reduction surgery. Design Prospective study of women attending an outpatient gynaecology clinic. Setting General gynaecology clinic at a Central London teaching hospital. Sample Women requesting labial reduction surgery and referred by their general practitioner. Methods The labia minora width and length were measured for all participants for comparison with published normal values. The presenting complaint was recorded, along with demographic details, expectations of surgery and sources of information regarding appearance of the labia. Main outcome measures Labial measurements, reported symptoms and expectations of surgery. Results The labia of all participants were within normal published limits, with a mean (SD) of 26.9 (12.8) mm (right labia), and 24.8 (13.1) mm (left labia). The majority of complaints were regarding appearance or discomfort. Expectations were to alter the appearance with surgery. Conclusions All women seeking surgery had normal-sized labia minora. Clear guidance is needed for clinicians on how best to care for the worried well woman seeking surgery. © 2011 The Authors BJOG An International Journal of Obstetrics and Gynaecology © 2011 RCOG.

BACKGROUND: Topographic correlation between the primary gastric tumor and the first peri- and extragastric lymphatic drain basin (solitary lymph node metastasis) on gastrectomy specimens, represents a reliable method to investigate and understand the exact pattern of lymphatic drainage from a gastric tumor. Analyzing that correlation, useful information regarding the extent of the appropriate oncological perigastric lymphadenectomy will be provided. We retrospectively evaluate the usefulness of a modified D2 lymphadenectomy in gastric cancer patients, based on the topographic correlation between the primary tumor and the location of the solitary lymph node metastases, as they were detected by histology and immunohistochemistry. MATERIALS AND METHOD: Between April 2003 and March 2010, 134 gastric cancer patients were submitted to a modified D2 lymphadenectomy. Postoperatively, the standard histological ex-amination by hematoxylin and eosin (HE) staining, disclosed metastatic infiltration of at least two lymph nodes in 90 patients, solitary lymph node metastases were histologically detected in 10 patients, while the remaining 34 patients were classified as pN0. All lymph nodes of the ten patients with histological solitary lymph node metastases, as well as the 34 patients who had been classified as pN0 by histology, were further submitted to immunohistochemistry for micrometastases detection. More than one micrometastases were detected in none of them, while in seven patients solitary micrometastases were detected either in the level I perigastric or in the level II extragastric lymph nodes stations (skip micrometastases). RESULTS: Solitary lymph node metastases were detected by histology in ten patients and by immunohistochemistry in additional seven (nine females and eight males). Solitary metastases were detected in the level I LN stations in seven patients (four by histology and three by immunohistochemistry) and in the level II LN stations in ten patients (six by histology and four by immunohistochemistry). In order of frequency, the solitary lymph node metastases were located in the no 7 (n = 6), no 6 (n = 4), no 9 (n = 2), no 5 (n = 2), no 4 (n = 1), no 8 (n = 1) and no 12 (n = 1) LN stations. Skip metastases encountered the 60% of the histologically detected, 57% of the immunohistochemically detected and 59% of all solitary lymph node metastases. 80% of solitary metastases in the level II LN stations, were mainly located in the nos 7-9 lymph node stations complex. Tumors of the lower and middle-third of the stomach were equally drained both to the level I and level II lymph node stations, while 67% of the tumors towards the lesser curvature, were mainly drained in the level II lymph node stations. CONCLUSION: D2 lymphadenectomy increases the number of true R0 resections. Thus, a modified D2 lymphadenectomy should be routinely performed in gastric cancer patients.

Unprecedented low-dispersion high-frequency acoustic excitations are observed in dense suspensions of elastically hard colloids. The experimental phononic band structure for SiO 2   particles with different sizes and volume fractions is well represented by rigorous full-elastodynamic multiple-scattering calculations. The slow phonons, which do not relate to particle resonances, are localized in the surrounding liquid medium and stem from coherent multiple scattering that becomes strong in the close-packing regime. Such rich phonon-matter interactions in nanostructures, being still unexplored, can open new opportunities in phononics.

A Comment on the Letter by Mark I. Stockman, Phys. Rev. Lett.PRLTAO0031-9007 106, 156802 (2011)10.1103/PhysRevLett.106.156802. The author of the Letter offers a Reply. © 2011 American Physical Society.

Triple-negative breast cancers are an aggressive subtype of breast cancer with poor survival, but there remains little known about the etiologic factors that promote its initiation and development. Commonly inherited breast cancer risk factors identified through genome-wide association studies display heterogeneity of effect among breast cancer subtypes as defined by the status of estrogen and progesterone receptors. In the Triple Negative Breast Cancer Consortium (TNBCC), 22 common breast cancer susceptibility variants were investigated in 2,980 Caucasian women with triple-negative breast cancer and 4,978 healthy controls. We identified six singlenucleotide polymorphisms, including rs2046210 (ESR1), rs12662670 (ESR1), rs3803662 (TOX3), rs999737 (RAD51L1), rs8170 (19p13.1), and rs8100241 (19p13.1), significantly associated with the risk of triple-negative breast cancer. Together, our results provide convincing evidence of genetic susceptibility for triple-negative breast cancer. ©2011 AACR.

Estrogen receptor (ER)-negative breast cancer shows a higher incidence in women of African ancestry compared to women of European ancestry. In search of common risk alleles for ER-negative breast cancer, we combined genome-wide association study (GWAS) data from women of African ancestry (1,004 ER-negative cases and 2,745 controls) and European ancestry (1,718 ER-negative cases and 3,670 controls), with replication testing conducted in an additional 2,292 ER-negative cases and 16,901 controls of European ancestry. We identified a common risk variant for ER-negative breast cancer at the TERT-CLPTM1L locus on chromosome 5p15 (rs10069690: per-allele odds ratio (OR) = 1.18 per allele, P = 1.0 × 10 -10). The variant was also significantly associated with triple-negative (ER-negative, progesterone receptor (PR)-negative and human epidermal growth factor-2 (HER2)-negative) breast cancer (OR = 1.25, P = 1.1 × 10 -9), particularly in younger women (<50 years of age) (OR = 1.48, P = 1.9 × 10 -9). Our results identify a genetic locus associated with estrogen receptor negative breast cancer subtypes in multiple populations. © 2011 Nature America, Inc. All rights reserved.

OBJECTIVES: Doripenem is a new carbapenem recently introduced into Europe. The COMParative Activity of Carbapenem Testing (COMPACT) study compared the susceptibility of common Gram-negative bacilli causing serious infections in hospitalized patients with doripenem, imipenem and meropenem. METHODS: Gram-negative isolates (4498 total: 2171 Pseudomonas species; 1910 Enterobacteriaceae; and 417 other Gram-negative bacilli) were collected from 80 centres in 16 countries in Europe, the Middle East and Africa during 2008-09. The MICs of doripenem, imipenem and meropenem were determined using Etest methodology and broth microdilution. Susceptibility was interpreted according to CLSI, EUCAST and FDA breakpoints. RESULTS: The MIC(90)s of doripenem, imipenem and meropenem for all isolates were 8, ≥64 and 32 mg/L, respectively. Doripenem had the lowest MIC(90) for Pseudomonas species at 16 mg/L, with imipenem and meropenem values of ≥64 mg/L. Enterobacteriaceae were highly susceptible to all three carbapenems, with MIC(90)s of doripenem, imipenem and meropenem of 0.06, 0.5 and 0.12 mg/L, respectively. Other Gram-negative isolates, predominantly Acinetobacter baumannii, were resistant to all three carbapenems (MIC(90) ≥64 mg/L). Susceptibility to doripenem was observed in 14.9% of isolates resistant to imipenem and/or meropenem. CONCLUSIONS: Doripenem showed excellent activity against Gram-negative isolates; generally it was more active than imipenem and at least as good as meropenem. Against Pseudomonas species, doripenem was more active than both imipenem and meropenem, with doripenem susceptibility observed for some imipenem- and/or meropenem-resistant isolates.

BACKGROUND: HIV-1 is characterized by increased genetic heterogeneity which tends to hinder the reliability of detection and accuracy of HIV-1 RNA quantitation assays. METHODS: In this study, the Abbott RealTime HIV-1 (Abbott RealTime) assay was compared to the Roche Cobas TaqMan HIV-1 (Cobas TaqMan) and the Siemens Versant HIV-1 RNA 3.0 (bDNA 3.0) assays, using clinical samples of various viral load levels and subtypes from Greece, where the recent epidemiology of HIV-1 infection has been characterized by increasing genetic diversity and a marked increase in subtype A genetic strains among newly diagnosed infections. RESULTS: A high correlation was observed between the quantitative results obtained by the Abbott RealTime and the Cobas TaqMan assays. Viral load values quantified by the Abbott RealTime were on average lower than those obtained by the Cobas TaqMan, with a mean (SD) difference of -0.206 (0.298) log(10) copies/ml. The mean differences according to HIV-1 subtypes between the two techniques for samples of subtype A, B, and non-A/non-B were 0.089, -0.262, and -0.298 log(10) copies/ml, respectively. Overall, differences were less than 0.5 log(10) for 85% of the samples, and >1 log(10) in only one subtype B sample. Similarly, Abbott RealTime and bDNA 3.0 assays yielded a very good correlation of quantitative results, whereas viral load values assessed by the Abbott RealTime were on average higher (mean (SD) difference: 0.160 (0.287) log(10) copies/ml). The mean differences according to HIV-1 subtypes between the two techniques for subtype A, B and non-A/non-B samples were 0.438, 0.105 and 0.191 log(10) copies/ml, respectively. Overall, the majority of samples (86%) differed by less than 0.5 log(10), while none of the samples showed a deviation of more than 1.0 log(10). CONCLUSIONS: In an area of changing HIV-1 subtype pattern, the Abbott RealTime assay showed a high correlation and good agreement of results when compared both to the Cobas TaqMan and bDNA 3.0 assays, for all HIV-1 subtypes tested. All three assays could determine viral load from samples of different HIV-1 subtypes adequately. However, assay variation should be taken into account when viral load monitoring of the same individual is assessed by different systems.

The propagation stage of uncertainty evaluation, known as the propagation of distributions, is in most cases approached by the GUM (Guide to the Expression of Uncertainty in Measurement) uncertainty framework which is based on the law of propagation of uncertainty assigned to various input quantities and the characterization of the measurand (output quantity) by a Gaussian or a t-distribution. Recently, a Supplement to the ISO-GUM was prepared by the JCGM (Joint Committee for Guides in Metrology). This Guide gives guidance on propagating probability distributions assigned to various input quantities through a numerical simulation (Monte Carlo Method) and determining a probability distribution for the measurand. In the present work the two approaches were used to estimate the uncertainty of the direct determination of cadmium in water by graphite furnace atomic absorption spectrometry (GFAAS). The expanded uncertainty results (at 95% confidence levels) obtained with the GUM Uncertainty Framework and the Monte Carlo Method at the concentration level of 3.01 μg/L were ±0.20 μg/L and ±0.18 μg/L, respectively. Thus, the GUM Uncertainty Framework slightly overestimates the overall uncertainty by 10%. Even after taking into account additional sources of uncertainty that the GUM Uncertainty Framework considers as negligible, the Monte Carlo gives again the same uncertainty result (±0.18 μg/L). The main source of this difference is the approximation used by the GUM Uncertainty Framework in estimating the standard uncertainty of the calibration curve produced by least squares regression. Although the GUM Uncertainty Framework proves to be adequate in this particular case, generally the Monte Carlo Method has features that avoid the assumptions and the limitations of the GUM Uncertainty Framework. © 2010 Elsevier B.V. All rights reserved.

Fe3Si is a ferromagnetic material with possible applications in magnetic tunnel junctions. When doped with Mn, the material shows a complex magnetic behavior, as suggested by older experiments. We employed the Korringa-Kohn-Rostoker Green-function method within density-functional theory in order to study the alloy Fe3-xMnxSi, with 0 <= x <= 1. Chemical disorder is described within the coherent potential approximation. In agreement with experiment, we find that the Mn atoms align ferromagnetically to the Fe atoms, and that the magnetization and Curie temperature drop with increasing Mn concentration x. The calculated spin polarization P at the Fermi level varies strongly with x, from P = -0.3 at x = 0 (ordered Fe3Si) through P = 0 at x = 0.28, to P = +1 for x > 0.75; i.e., at high Mn concentrations the system is half metallic. We discuss the origin of the trends of magnetic moments, exchange interactions, Curie temperature, and the spin polarization.

Early prediction of human intestinal absorption is important in selection of potential orally administered drugs. Various computational models for prediction of the fraction of dose absorbed, Fa, have been developed. In 1989, a sigmoidal relationship between Fa and drug absorption potential was shown. Since then various physicochemical descriptors of molecules (lipophilicity, polar surface area, hydrogen bond descriptors) have been found to correlate with human intestinal absorption and various attempts in estimating Fa have been reported. Most studies rely on the presupposition that Fa is mainly dependent on drug's solubility, which drives the dissolution rate in the gastrointestinal (GI) fluids, and the rate of passive drug transport across the intestinal membrane. In the same vein, the biopharmaceutics classification system (BCS) and the relevant FDA guideline classify drugs in four categories according to their aqueous solubility and permeability. However, the biopharmaceutics drug disposition classification system (BDDCS) revealed the poor predictability of permeability estimates for Fa and the major role of transporters for GI uptake of drugs. The role of solubility in the reaction limited model of dissolution and the ubiquitous presence of supersaturated solubility-dissolution phenomena in the GI lumen, call for a more physiologically relevant consideration of GI absorption.

Biochemical markers of bone turnover provide insight into ongoing rates of skeletal metabolism and tumor-bone interactions in patients with malignant bone disease. This article reviews the available recent evidence assessing the potential of bone markers for detecting and monitoring malignant bone lesions in patients with advanced cancers, and for assessing overall skeletal health and response to antiresorptive therapies in patients at all stages of cancer progression. Most data thus far are for urinary N-terminal cross-linked telopeptide of type I collagen (NTX) in predicting risks of skeletal morbidity and death and monitoring response to zoledronic acid in patients with bone metastases. Ongoing studies are evaluating such correlations for other markers and therapies. Emerging evidence suggests that bone markers may help identify patients at high risk for bone metastasis or bone lesion progression, thereby allowing improved follow-up. Results from ongoing clinical trials evaluating such potential applications of bone markers are awaited. © 2011 Elsevier Ireland Ltd.

A panel of members of the 2009 International Myeloma Workshop developed guidelines for risk stratification in multiple myeloma. The purpose of risk stratification is not to decide time of therapy but to prognosticate. There is general consensus that risk stratification is applicable to newly diagnosed patients; however, some genetic abnormalities characteristic of poor outcome at diagnosis may suggest poor outcome if only detected at the time of relapse. Thus, in good-risk patients, it is necessary to evaluate for high-risk features at relapse. Although detection of any cytogenetic abnormality is considered to suggest higher-risk disease, the specific abnormalities considered as poor risk are cytogenetically detected chromosomal 13 or 13q deletion, t(4;14) and del17p, and detection by fluorescence in situ hybridization of t(4;14), t(14;16), and del17p. Detection of 13q deletion by fluorescence in situ hybridization only, in absence of other abnormalities, is not considered a high-risk feature. High serumβ2-microglobulin level and International Staging System stages II and III, incorporating high β 2-microglobulin and low albumin, are considered to predict higher risk disease. There was a consensus that the high-risk features will change in the future, with introduction of other new agents or possibly new combinations. © 2011 by The American Society of Hematology.

A panel of members of the 2009 International Myeloma Workshop developed guidelines for standard investigative workup of patients with suspected multiple myeloma. Both serum and urine should be assessed for monoclonal protein. Measurement of monoclonal protein both by densitometer tracing and/by nephelometric quantitation is recommended, and immunofixation is required for confirmation. The serum-free light chain assay is recommended in all newly diagnosed patients with plasma cell dyscrasias. Bone marrow aspiration and/or biopsy along with demonstration of clonality of plasma cells are necessary. Serum β2-microglobulin, albumin, and lactate dehydrogenase are necessary for prognostic purposes. Standard metaphase cytogenetics and fluorescent in situ hybridization for 17p, t(4;14), and t(14;16) are recommended. The skeletal survey remains the standard method for imaging screening, but magnetic resonance imaging frequently provides valuable diagnostic and prognostic information. Most of these tests are repeated during follow-up or at relapse. © 2011 by The American Society of Hematology.

It is essential that there be consistency in the conduct, analysis, and reporting of clinical trial results in myeloma. The goal of the International Myeloma Workshop Consensus Panel 1 was to develop a set of guidelines for the uniform reporting of clinical trial results in myeloma. This paper provides a summary of the current response criteria in myeloma, detailed definitions for patient populations, lines of therapy, and specific endpoints. We propose that future clinical trials in myeloma follow the guidelines for reporting results proposed in this manuscript. © 2011 by The American Society of Hematology.

The phosphoglucomutase gene from a wild type Fusarium oxysporum   strain (F3), was homologously expressed, under the control of the constitutive promoter of gpdA of Aspergillus nidulans. The transformant produced elevated levels of phosphoglucomutase activity compared to the wild type, a fact that facilitated the subsequent purification procedure. The enzyme (FoPGM) was purified to homogeneity applying three anion exchange and one gel filtration chromatography steps. The native enzyme revealed a monomeric structure with a molecular mass of 60 kDa, while the isoelectric point was 3.5. FoPGM was active in pH ranged from 6.0 to 8.0, with an optimum using 3-(N-morpholino)propanesulfonic acid buffer at 7.0, while loss of activity was observed when phosphate buffer was used in the above mentioned pH range. The optimal temperature for activity was 45 °C but the enzyme became unstable at temperatures above 40 °C. FoPGM requires the presence of a divalent cation for its function with maximum activity being obtained with Co2+. The apparent Km for Co2+ was found to be 10 μM. The enzyme was also active with other divalent metal ions such as Mn2+, Mg2+, Ni2+ and Ca2+ but to a lesser extent. The following kinetic constants were determined: vmax, 0.74 μmol mgprotein−1 min−1; kcat, 44.2 min−1; Km(G1P), 0.10 mM;Km(G1,6diP), 1.03 μM; kcat/Km(G1P), 443 mM−1 min−1 and kcat/Km(G1,6diP), 42,860 mM−1 min−1. The enzyme was considered to follow a Ping Pong substituted enzyme or enzyme isomerization mechanism.

The effects of hydrothermal and thermal treatments on surface oxygen functionalization of single-wall carbon nanotubes (SWNTs) were quantitatively investigated by means of water adsorption/desorption, temperature-programmed desorption (TPD), Raman spectroscopy, thermogravimetric analysis, and nitrogen porosimetry. SWNTs hydrothermally treated under mild acidic conditions were compared to highly purified reference materials heavily functionalized under aggressive reflux conditions. Water adsorption/desorption and TPD analysis were successfully combined to determine the nature, concentration, thermal stability, and acidic strength of the oxygen functional groups on the SWNT's surface. These results were correlated to Raman spectroscopy data that allowed identifying the marked evolution of the defect-activated phonon modes of SWNTs. The concomitant charge transfer effects were differentiated through the distinct variation of both first- and second-order Raman modes as a function of the amount and acidity of the surface oxygen groups as well as the SWNT's chirality. In addition, analytical investigations on thermally treated SWNTs in mild oxidative (in air) and pyrolytic conditions (under Ar) confirmed the formation of amorphous carbon that depends primarily on the acidification process, although a significant fraction of functional groups remains attached on the SWNTs' walls rather than on carboxylated carbonaceous fragments. Quenched solid density functional theory (QSDFT) analysis of the bimodal pore size distribution of the functionalized SWNTs revealed pronounced variations of the underlying microporous and mesoporous structure, associated with the diverse effects of the packing between SWNT bundles and the closer aggregation of individual carbon nanotubes upon surface oxidation and thermal treatment. The SWNTs functionalization procedure can be effectively controlled and quantified, and the optimum conditions can be defined in relation to the desired physicochemical properties and pore structure characteristics for specific applications. © 2011 American Chemical Society.

This study examines firm’s stock returns’ behaviour, when they announce corporate events like management change, collaborations and stock repurchase. It examines how this change is portrayed in firms’ stock prices returns. The methodologies used are the methodology of event study analysis and bootstrap methodology. Companies selected belong to eight different sectors of Athens Stock Exchange with different Stock Exchange value in order to get a more general picture that does not only represent one sector which can be influenced individually from accidental factors. The sample constitutes forty firms listed in Athens Stock Exchange. Results indicate that corporate events’ impact is important and a key for enterprises to follow new challenges and create financial value. This paper provides evidence on the impact of corporate governance on stock returns in Greece. The implication is that corporate events create financial value.

Malassezia yeasts are found on the skin of all humans and many warm-blooded animals. In vitro they have the ability to synthesize potent ligands (indolo[3,2-b]carbazole, malassezin and indirubin) of the aryl-hydrocarbon receptor (AhR; synonym: dioxin receptor) when the sweat contained l-tryptophan is used as the single nitrogen source. The production of these AhR-ligands has been associated with pathogenic strains of a certain Malassezia species (Malassezia furfur) but recent evidence shows that this property is widely distributed in almost all currently known Malassezia species. AhR is associated with carcinogenesis and the potential connection of these ubiquitous skin symbionts, and putative pathogens, with skin neoplasia should be evaluated mainly focusing on mechanisms related to the distinctive ability of the yeast to produce potent AhR ligands. Hypothesis: Synthesis of available pertinent data show a possible link between Malassezia produced AhR ligands and skin carcinogenesis, particularly of basal cell carcinoma (BCC).BCCs are almost exclusively observed in animal species colonized by Malassezia. In humans and animals there is overlapping in the skin regions colonized by this yeast and affected by BCC. The potent AhR ligands synthesized by pathogenic Malassezia strains could contribute to tumor promotion by: modification of the UV radiation carcinogenesis, alterations in the salvage/survival of initiated tumor cells, inhibition of cell senescence, interaction with vitamin D metabolism, promotion of immune tolerance and finally pro-carcinogenic modulation of cell cycle progression and apoptosis. © 2011 Elsevier Ltd.

Η εργασία αυτή εξετάζει την προβολή του γυναικείου αθλητισμού στα ΜΜΕ: ΗΠΑ, Αυστραλία, Ελλάδα. Ειδικά στις ΗΠΑ επισημαίνεται η «κρίση στο γυναικείο αθλητισμό» όπου η τηλεοπτική κάλυψη γυναικείων αγώνων είναι λιγότερη από ότι ήταν πριν 20 χρόνια [1]. Από την ανασκόπηση της βιβλιογραφίας και την επεξεργασία πρόσφατων συζητήσεων και ποσοτικών και ποιοτικών αναλύσεων γίνεται φανερό ότι: Πρώτον, η αθλήτρια απολαμβάνει, σε αντίθεση με το παρελθόν, μια εκρηκτική παρουσία στα ΜΜΕ, αλλά όχι για την αθλητική της ιδιότητα. Δεύτερον, εντοπίζονται ‘ίσες ευκαιρίες’ στην εμπορευματοποίηση-‘μοντελοποίηση’ του σώματος και της αθλητικής ταυτότητας: προβολή των άφυλων αθλητών/τριών, θηλυκοποίηση του αθλητή και αρρενοποίηση της αθλήτριας. Τρίτον, σταδιακά καταρρίπτονται οι θεωρήσεις ότι μόνο το γυναικείο σώμα αντικειμενικοποιείται. Τέλος, διαπραγματευόμαστε εναλλακτικά αθλητικά μοντέλα, μια ολιστική προσέγγιση, ενόψει της εμπορικής παγκοσμιοποίησης του Αθλητισμού και της αθλητικής ταυτότητας. Οι κλωνοποιημένοι αθλητές-ήρωες και αθλήτριες-ηρωίδες που προβάλλονται στα ΜΜΕ δεν εκπροσωπούν την πλειονότητα των αθλητών/τριών της κοινωνικής περιοχής του αθλητισμού. Ένας αυξανόμενος αριθμός ανώνυμων-ηρωίδων - αθλητριών, γυμναστριών, ερευνητριών - δουλεύουν έξω από τη δεσπόζουσα τάση της εποχής και αγωνίζονται για τη δημιουργία καινούριων αθλητικών μοντέλων και προτύπων, για την προστασία και ακεραιότητα του αθλητή/τριας και της αθλητικής δεοντολογίας. Messner, M. A., Hextrum, R., Nyad, D. (2010). Gender in Televised Sports, June 2010, διαθέσιμο στην ιστοσελίδα: http://www.usc.edu/dept/cfr/html/documents/tvsports.pdf. Pfister, Gertrud (2010) 'Women in sport - gender relations and future perspectives', Sport in Society, 13: 2, 234 - 248. Report (2010). “New Report Reveals Poor Media Coverage of Women in Sport”, Australia. Διαθέσιμο στην ιστοσελίδα: http://www.ausport.gov.au/participating/women/research. IOC Report (2005) "Women’s Participation at the Games of the XXVIIIE Olympiad: Athens 2004: Statistics.". IOC, Department of International Cooperation and Development. Ελληνικός έντυπος τύπος: Ολυμπιάδες 2008, 2004, 2000 (Καθημερινή, Βήμα, Ριζοσπάστης). Πρακτικά Συνεδρίου: http://www.tefaacongress.gr/2011/Proceedings.html

Expression of the clusterin (CLU) gene results in the synthesis of a conventional secretory isoform set (pre- and mature secretory clusterin proteins, psCLU/sCLU), as well as another set of intracellular isoforms, appearing in the cytoplasm (pre-nuclear CLU, pnCLU) and in the nucleus as an ∼55-kDa mature nuclear clusterin (nCLU) form. These two isoform sets have opposing cell functions: pro-survival and pro-death, respectively. Although much is known about the regulation and function of sCLU as a pro-survival factor, the regulation and function of endogenous nCLU in cell death are relatively unexplored. Here, we show that depletion of endogenous nCLU protein using siRNA specific to its truncatedmRNAincreased clonogenic survival of ionizing radiation (IR)-exposed cells. nCLU-mediated apoptosis was Bax-dependent, and lethality correlated with accumulation of maturenCLUprotein.nCLUaccumulation was regulated by CRM1 because binding between CRM1 and nCLU proteins was significantly diminished by leptomycin B (LMB), and nuclear levels of nCLU protein were significantly enhanced by LMB and IR co-treatment. Moreover, LMB treatment significantly enhanced IR-induced nCLU-mediated cell death responses. Importantly, bax -/- and bax -/-/bak -/- double knock-out cells were resistant to nCLU-mediated cell death, whereas bak -/- or wild-type bax +/+/bak +/+ cells were hypersensitive. The regulation of nCLU by CRM1 nuclear export/import may explain recent clinical results showing that highly malignant tumors have lost the ability to accumulate nCLU levels, thereby avoiding growth inhibition and cell death. © 2011 by The American Society for Biochemistry and Molecular Biology, Inc.

Osteonecrosis of the jaw is an uncommon but potentially serious complication of bisphosphonate therapy in multiple myeloma. Previous studies showed that the presence of one or two minor alleles of the cytochrome P450, subfamily 2C polypeptide 8 gene (CYP2C8) polymorphism rs1934951 was an independent prognostic marker associated with development of osteonecrosis of the jaw in multiple myeloma patients treated with bisphosphonates. The aim of this study was to validate the frequency of SNP rs193451 in 79 patients with multiple myeloma. In 9 (22%) patients developing osteonecrosis of the jaw, a heterozygous genotype was found, in contrast with those who did not develop osteonecrosis of the jaw (n=4, 11%) or healthy individuals (n=6, 13%). We found no differences in the cumulative risk of developing osteonecrosis of the jaw between patients homozygous and heterozygous for the major allele. We were unable to confirm a significant association between this polymorphism and the risk of developing osteonecrosis of the jaw. © 2011 Ferrata Storti Foundation.

Aims: The largest Local Group spiral galaxy, M 31, has been completely imaged for the first time, obtaining a luminosity lower limit ~1035 erg s-1 in the 0.2-4.5 keV band. Our XMM-Newton EPIC survey combines archival observations along the major axis, from June 2000 to July 2004, with observations taken between June 2006 and February 2008 that cover the remainder of the D25 ellipse. The main goal of the paper is to study the X-ray source population of M 31. Methods: An X-ray catalogue of 1897 sources was created, with 914 detected for the first time. Source classification and identification were based on X-ray hardness ratios, spatial extent of the sources, and cross correlation with catalogues in the X-ray, optical, infrared, and radio wavelengths. We also analysed the long-term variability of the X-ray sources and this variability allows us to distinguish between X-ray binaries and active galactic nuclei (AGN). Furthermore, supernova remnant classifications of previous studies that did not use long-term variability as a classification criterion could be validated. Including previous Chandra and ROSAT observations in the long-term variability study allowed us to detect additional transient or at least highly variable sources, which are good candidate X-ray binaries. Results: Fourteen of the 30 supersoft source (SSS) candidates represent supersoft emission of optical novae. Many of the 25 supernova remnants (SNRs) and 31 SNR candidates lie within the 10 kpc dust ring and other star-forming regions in M 31. This connection between SNRs and star-forming regions implies that most of the remnants originate in type II supernovae. The brightest sources in X-rays in M 31 belong to the class of X-ray binaries (XRBs). Ten low-mass XRBs (LMXBs) and 26 LMXB candidates were identified based on their temporal variability. In addition, 36 LMXBs and 17 LMXB candidates were identified owing to correlations with globular clusters and globular cluster candidates. From optical and X-ray colour-colour diagrams, possible high-mass XRB (HMXB) candidates were selected. Two of these candidates have an X-ray spectrum as is expected for an HMXB containing a neutron star primary. Conclusions: While our survey has greatly improved our understanding of the X-ray source populations in M 31, at this point 65% of the sources can still only be classified as "hard" sources; i.e. it is not possible to decide whether these sources are X-ray binaries or Crab-like supernova remnants in M 31 or X-ray sources in the background. Deeper observations in X-ray and at other wavelengths would help classify these sources. Based on observations obtained with XMM-Newton, an ESA science mission with instruments and contributions directly funded by ESA Member States and NASA.Tables 5 and 8 are only available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/534/A55

Dieser Artikel zielt darauf, Friedrich Ratzels politisch-geographische Wahrnehmung des Staates hinzuweisen. Zunächst wird gezeigt, dass Ratzels Sichtpunkt frei von organistischen oder metaphysischen Elementen ist. Endlich wird es untersucht werden, wie Ratzel den Staat als Ausdruck des neuen gesellschaftlichen Lebens (new social life) wahrnimmt.

Ground-based gamma-ray astronomy has had a major breakthrough with the impressive results obtained using systems of imaging atmospheric Cherenkov telescopes. Ground-based gamma-ray astronomy has a huge potential in astrophysics, particle physics and cosmology. CTA is an international initiative to build the next generation instrument, with a factor of 5-10 improvement in sensitivity in the 100 GeV-10 TeV range and the extension to energies well below 100 GeV and above 100 TeV. CTA will consist of two arrays (one in the north, one in the south) for full sky coverage and will be operated as open observatory. The design of CTA is based on currently available technology. This document reports on the status and presents the major design concepts of CTA.

Ground-based gamma-ray astronomy has had a major breakthrough with the impressive results obtained using systems of imaging atmospheric Cherenkov telescopes. Ground-based gamma-ray astronomy has a huge potential in astrophysics, particle physics and cosmology. CTA is an international initiative to build the next generation instrument, with a factor of 5-10 improvement in sensitivity in the 100 GeV-10 TeV range and the extension to energies well below 100 GeV and above 100 TeV. CTA will consist of two arrays (one in the north, one in the south) for full sky coverage and will be operated as open observatory. The design of CTA is based on currently available technology. This document reports on the status and presents the major design concepts of CTA.

Ground-based gamma-ray astronomy has had a major breakthrough with the impressive results obtained using systems of imaging atmospheric Cherenkov telescopes. Ground-based gamma-ray astronomy has a huge potential in astrophysics, particle physics and cosmology. CTA is an international initiative to build the next generation instrument, with a factor of 5-10 improvement in sensitivity in the 100 GeV-10 TeV range and the extension to energies well below 100 GeV and above 100 TeV. CTA will consist of two arrays (one in the north, one in the south) for full sky coverage and will be operated as open observatory. The design of CTA is based on currently available technology. This document reports on the status and presents the major design concepts of CTA.

Ground-based gamma-ray astronomy has had a major breakthrough with the impressive results obtained using systems of imaging atmospheric Cherenkov telescopes. Ground-based gamma-ray astronomy has a huge potential in astrophysics, particle physics and cosmology. CTA is an international initiative to build the next generation instrument, with a factor of 5-10 improvement in sensitivity in the 100 GeV-10 TeV range and the extension to energies well below 100 GeV and above 100 TeV. CTA will consist of two arrays (one in the north, one in the south) for full sky coverage and will be operated as open observatory. The design of CTA is based on currently available technology. This document reports on the status and presents the major design concepts of CTA.

The synthesis of a number of new benzothiopyrano[4,3,2-cd]isoindole aminoderivatives designed as structural analogues of the key metabolite of the anticancer agent Ledacrine (nitracrine) and their in vitro cytotoxic activity evaluation against HCT-116, MES-SA, and MES-SA/Dx cancer cell lines is reported. The majority of the derivatives possessed noticeable cytotoxicity in a low μM range indicating an interesting structure-activity relationship. © 2011 Elsevier Ltd. All rights reserved.

A real-time PCR targeting IS6110 was employed for the detection of Mycobacterium tuberculosis DNA in specimens collected from 10 patients treated with intravesical M. bovis bacillus Galmette-Guérin (BCG) immunotherapy for bladder malignancy. BCG DNA was detected in all urine specimens taken 24 h after the instillations, as well as in 24% of the specimens collected 7 days after the instillations; it was also detected in a single specimen taken 6 weeks after the last instillation. BCG DNA was detected in 8.3% of the blood specimens taken 1 day after instillation, and its amplification was associated with cases of self-limiting fever. These findings give indications that this real-time PCR is helpful to recognize BCG bacteremic cases, which may lead to mycobacterial infection.

Re-injury worry is an important construct in competitive sport that may influence performance and increase the risk of re-injury. However, there are currently no available instruments to measure the causes of re-injury worry. The purpose of this study was to develop the Causes of Re-Injury Worry Questionnaire (CR-IWQ). The study was conducted in three independent research phases to investigate the following: (a) the content relevance, (b) the factor structure and the factorial validity, (c) the concurrent validity, (d) the discriminant validity, and (e) the test-retest reliability (intraclass correlation coefficients; ICC), and the internal consistency of the instrument. Exploratory factor analysis (EFA) was chosen to examine the factor structure of the CR-IWQ. Confirmatory factor analysis (CFA) was used to examine further the factorial validity of the instrument. A number of valid constructs were used to assess the concurrent and discriminant validity of the CR-IWQ. The reliability of the new instrument was examined using Pearson r (ICC) and Cronbach . Three hundred and seventy athletes with an acute musculoskeletal sport injury in the last year participated in the study. EFA revealed a 12-item model, representing two factors (Re-injury worry due to rehabilitation and Re-injury worry due to opponent’s ability). CFA supported the two-factor model of the CR-IWQ. The concurrent and discriminant validity of the CR-IWQ was confirmed by examining correlations between the CR-IWQ with other constructs. The ICCs and the Cronbach indices of the CR-IWQ were acceptable. We have demonstrated that the CR-IWQ is a good psychometric instrument that can be used for clinical and research purposes. © 2011 Taylor & Francis.

Systemic treatment represents the cornerstone of endometrial cancer management in advanced, relapsed and metastatic disease, which is still characterized by poor prognosis. Progestins remain an effective option for patients with low grade, estrogen and/or progesterone receptor positive disease, with some of them achieving prolonged survival. Platinum compounds, anthracyclines and more recently taxanes have been implemented in combination regimens achieving response rates more than 50% and resulting in overall survival above 1 year in randomized trials. Adjuvant chemotherapy with the same agents may be useful for patients with early stage disease and high-risk features, such as high grade or non-endometrioid histology. Combination of chemotherapeutic agents with radiotherapy remains investigational. Hematologic, cardiac toxicity and neurotoxicity represent the main concern of chemotherapy and increase the risk for treatment-related morbidity and death, especially in pretreated patients bearing substantial co-morbidities. The gradual elucidation of the molecular aspects of endometrial carcinogenesis has led to the development of novel, selective antineoplastic agents, targeting specific molecular pathways and mediators of signal transduction implemented in cell proliferation, survival and angiogenesis. In the current review, we report on the recent advances regarding systemic therapy of endometrial carcinoma with special emphasis on results of large, randomized phase III clinical trials. Biomarkers with potent prognostic significance or predictive value for response to treatment are presented and novel molecular agents showing promising results in early clinical trials are discussed. © 2010 Elsevier Ireland Ltd.

 The paper aims to point out some of the relations between land and state in Friedrich Ratzel political-geographic analysis. First, it will be demonstrated how the perception of the land correlates with the culture situation of the observer. Second, it will be shown how political space is situated in Ratzel’s analytical system of power. At last it will be examined how far Ratzel estimates both, geographical and human factors, in his political system and decision making process.

It has been suggested that inflammation is involved in Alzheimer disease (AD) pathogenesis. The aim of this study is to evaluate the association between inflammatory aspects of diet and incident AD risk. About 2258 nondemented elderly (age ≥ 65) in New York who provided dietary information at baseline were followed-up prospectively for AD development. We examined the composite total Inflammation Factor Rating (tIFR), as a measure of inflammatory impact of foods, in relation with (i) serum level of high-sensitivity C-reactive protein (hsCRP) and (ii) risk of incident AD using Cox proportional hazard model. The tIFR was not associated with serum hsCRP level. After an average of 4.0 years of follow-up, 262 participants developed incident AD. The tIFR was not associated with AD risk: compared with the lowest tertile of tIFR (most proinflammatory), hazard ratios (95% confidence interval) for the highest tertile (most anti-inflammatory) was 0.97 (0.69-1.35) (P-for-trend=0.71), in the adjusted model. We conclude that tIFR might not be a biologically relevant measure of the inflammatory impact of the diet. In addition, although it remains possible that tIFR might be related with some other aspects of inflammation not captured by hsCRP, lack of association with AD risk suggests its limited clinical utility.

It has been suggested that inflammation is involved in Alzheimer disease (AD) pathogenesis. The aim of this study is to evaluate the association between inflammatory aspects of diet and incident AD risk. About 2258 nondemented elderly (age >/= 65) in New York who provided dietary information at baseline were followed-up prospectively for AD development. We examined the composite total Inflammation Factor Rating (tIFR), as a measure of inflammatory impact of foods, in relation with (i) serum level of high-sensitivity C-reactive protein (hsCRP) and (ii) risk of incident AD using Cox proportional hazard model. The tIFR was not associated with serum hsCRP level. After an average of 4.0 years of follow-up, 262 participants developed incident AD. The tIFR was not associated with AD risk: compared with the lowest tertile of tIFR (most proinflammatory), hazard ratios (95% confidence interval) for the highest tertile (most anti-inflammatory) was 0.97 (0.69-1.35) (P-for-trend=0.71), in the adjusted model. We conclude that tIFR might not be a biologically relevant measure of the inflammatory impact of the diet. In addition, although it remains possible that tIFR might be related with some other aspects of inflammation not captured by hsCRP, lack of association with AD risk suggests its limited clinical utility.

Much of the attention on diet and Alzheimer's disease (AD) or cognition among the elderly has focused on the role of single nutrients or foods, while available information on dietary pattern (DP) analysis, which better reflects the complexity of the diet, is sparse. In this review, we describe different patterning approaches and present studies performed to date that have assessed the associations between DPs and risk of AD or cognitive function in the elderly. Three patterning approaches have been most commonly used: (i) hypothesis-based that use dietary quality indexes or scores (e.g. Mediterranean pattern), (ii) data-driven that use factor or cluster analysis to derive DPs, (iii) reduced rank regression which combines characteristics of the former two approaches. Despite differences existing among the approaches, DPs characterized by higher intake of fruits, vegetables, fish, nuts and legumes, and lower intake of meats, high fat dairy, and sweets seemed to be associated with lower odds of cognitive deficits or reduced risk of AD. Overall, the inherent advantages as well as the existing evidence of DP analyses strongly suggest that this approach may be valuable in AD and aging research. Further studies are warranted, though, to confirm the findings in different population settings, to address some methodological issues, and possibly utilize the information for future clinical trial design.

Greece under severe financial and economic crisis has accepted the control of the World Monetary Fund and the European Union. Among other measures imposed on Greece is government funding to remain at 5 per cent of the GDP until 2030. In order to fulfill this obligation, Laws 3863 and 3865/2010 have been passed. With these laws, the distinction between basic pension and contributory pension is introduced. A theoretical mathematical model based on social security principles for calculating the aggregate pension (basic pension and contributory pension) is presented and compared to the model that corresponds to the recent reform to the Greek pension scheme. Apart from the social and economic merits of this reform, some paradoxes and shortcomings are pointed out.

This article addresses the distinction between interpretation and application of international legal norms and argues that it constitutes an issue central to the theory and practice of international adjudication. The distinction, though sometimes negated, surpassed or simply neglected, in fact exists and should be drawn by international lawyers, especially vis-a‘-vis the challenges set by the fragmentation of international law. Ergo, an illustrative operative sketch of juridical reasoning delimiting the two processes in the course of international dispute settlement is suggested by distinguishing between interpretation, interpretative application and application stricto sensu, as all taking place in the context of application lato sensu of international legal norms. The article concludes by turning to the secondary norms on state responsibility and the general principles of estoppel and acquiescence as noteworthy examples of lato sensu application of leges generales in international settlement of disputes.

Aiming at portraying the Aegean's water mass structure and identifying Dense Water Formation processes, two winter cruises were conducted in 2005?2006, across the plateaus and depressions of the Aegean Sea. The most prominent feature of the water mass distribution in the basin is a distinct ?X-shape? of the Θ-S characteristics, suggesting a complicated coupling of the major Aegean sub-basins. The surface and deep waters are relatively decoupled with diverse origin characteristics, while the intermediate layers act as connectors of the main thermohaline cells. The Central Aegean seems to play a key role due to formation processes of water masses with densities equal and/or higher than 29.2 kg/m3, that take place in the sub-basin and disperses in the North Aegean. On the other hand, the South Aegean appears greatly influenced by the Eastern Mediterranean circulation and water mass distribution, especially under the Eastern Mediterranean Transient status. The Transitional Mediterranean Water monitored in the post-EMT period and characterized by low temperature at 14.2°C, low salinity at 38.92 and low dissolved oxygen at 3.97 ml/l, with its core around 750 m and above the saline (39.06) Cretan Deep Water, altered significantly the South Aegean structure. The pre-EMT thermohaline pattern of the Central and South Aegean deep layers were similar, while the bottom density of the Central basin was higher than that in the South Aegean. Thus, it is possible that the deep waters of the Central Aegean acted as a dense water reserve supply for the deeper part of the Southern basin.

If improved relations between Turkey and Greece simply meant the implementation of of modest CBMs, more trade and regular meetings between the leaders of the two countries then the bilateral relationship seems better than perhaps at any time since the 1930s. But in the context of the issues that have bedevilled bilateral relations for over thirty years, these changes have not been profound. This paper tries to answer why the ongoing dialogue between Ankara and Athens since 1999 has not led to reconciliation over differences in the Aegean.

This volume emerged from a collaborative Network of Excellence project funded by the European Commission. The Network, which comprises thirty-two institutes from Europe and beyond, integrates European research capabilities across disciplines and countries to provide the society and the state with tools for managing cultural diversity as a key element of sustainable development. The work presented here describes the emergence and increasing importance of diversity within academic research and practice and offers valuable insights on diversity management and policy implementation.

The addition of H2 across a transition metal-borane bond is reported for the first time providing a mechanism for recharging borane functional groups to borohydride. © 2010 The Royal Society of Chemistry.

BACKGROUND: Kallikrein-related peptidase 5 (KLK5) is a secreted trypsin-like protease of the KLK family, encoded by the KLK5 gene. KLK5 has been found to cleave various extracellular matrix components, as well as to activate several other KLK proteases, triggering the stimulation of tissue microenvironment proteolytic cascades. MATERIAL AND METHODS: KLK5 expression levels were quantified in 102 cancerous and benign breast tissue specimens, obtained by randomly chosen patients, using RT-qPCR assay. Subsequently, advanced biostatistics were applied in order to analyze the KLK5 expression profile in the two patients' cohorts and also to evaluate its clinical significance for the discrimination of breast tumors. RESULTS: A statistically significant (p < 0.001) down-regulation of the KLK5 expression levels were observed in the malignant specimens compared to the benign ones. Logistic regression and ROC curve analysis revealed the significant (p < 0.001) and the independent (p < 0.001) value of the KLK5 expression quantification, for the discrimination of the malignant from the benign mammary gland biopsies. Moreover, KLK5 expression levels correlate with the pre-menopausal status (p < 0.005) as well as the ER-negative staining (p = 0.028) of women with breast cancer. CONCLUSIONS: The quantification of KLK5 expression in breast tissue biopsies may be considered as a novel and independent biomarker for the differential diagnosis between malignant and benign tumors of the mammary gland.

Plasmonic metamaterials form an exciting new class of engineered media that promise a range of important applications, such as subwavelength focusing, cloaking and slowing/stopping of light. At optical frequencies, using gain to overcome potentially not insignificant losses has recently emerged as a viable solution to ultralow-loss operation that may lead to next-generation active metamaterials. Here, we employ a Maxwell-Bloch methodology for the analysis of these gain-enhanced optical nanomaterials. The method allows us to study the dynamics of the coherent plasmon-gain interaction, nonlinear saturation, field enhancement as well as radiative and non-radiative damping such as tunnelling and Förster coupling. Using numerical pump-probe experiments on a double-fishnet metamaterial with dye-molecule inclusions we investigate the build-up of the inversion and the formation of the plasmonic modes in the low-Q fishnet cavity. We find that loss compensation occurs in the negative-refractiveindex regime and that, due to the loss compensation and the associated sharpening of the resonance, the real part of the refractive index of the metamaterial becomes more negative compared to the passive case. Furthermore, we investigate the behaviour of the metamaterial above the lasing threshold, and we identify the occurrence of a far-field lasing burst and gain depletion when higher dye densities are used. Our results provide deep insight into the internal processes that affect the macroscopic properties of active metamaterials. This could guide the development of amplifying and lasing plasmonic nanostructures. © 2011 Copyright Society of Photo-Optical Instrumentation Engineers (SPIE).

Pompe disease is a rare autosomal recessive disorder characterized by the deficiency of acid α-glycosidase resulting in lysosomal accumulation of glycogen. The late-onset disease form is characterized by progressive skeletal and respiratory muscle dysfunction. In addition to the recently introduced enzyme replacement therapy (ERT), treatments such as protein-enriched diet and exercise training have been proposed, although little is known about their effectiveness on the physical condition of such patients. Aim of the present study was to investigate the effect of exercise training on muscular strength and body composition in five patients with late-onset Pompe disease receiving ERT. All subjects followed a 20 week lasting program of supervised aerobic and progressive resistance exercise training. Before and after the training period, body composition was determined with dual X-ray absorptiometry and isometric muscular strength was measured with a specialized load transducer. Functional capacity was assessed using the 6-min shuttle walk test. A significant increase in muscular strength (15-50% at various body parts, p<0.05) and 6-minute walking distance (203.8 ± 177 m before vs. 248.2 ± 184 m after, p<0.01) was observed after training, whereas total and lower extremities lean body mass did not change significantly. These results suggest that exercise training has a positive effect on muscular strength and functional capacity in patients on ERT with late-onset Pompe disease.

This paper considers the problem of optimal pricing in a system serving two classes of customers differentiated by their delay sensitivities. We derive the revenue maximising pricing policies whether or not price discrimination is an option. We find that in both cases the optimal policy causes the less delaysensitive class to enter first, and the optimal prices are increasing in capacity under price discrimination, which is not generally true when price discrimination is not allowed. Furthermore, under price discrimination, less capacity is needed to capture a customer class or the entire market, while, more customers are served and higher revenue is generated. Finally, we use an M/M/1 system to provide further insights and numerical analysis. © 2011 Inderscience Enterprises Ltd.

BACKGROUND: In most patients with COPD, rehabilitative exercise training partially reverses the morphologic and structural abnormalities of peripheral muscle fibers. However, whether the degree of improvement in muscle fiber morphology and typology with exercise training varies depending on disease severity remains unknown. METHODS: Forty-six clinically stable patients with COPD classified by GOLD (Global Initiative for Obstructive Lung Disease) as stage II (n = 14), III (n = 18), and IV (n = 14) completed a 10-week comprehensive pulmonary rehabilitation program consisting of high-intensity exercise three times weekly. RESULTS: At baseline, muscle fiber mean cross-sectional area and capillary density did not significantly differ between patients with COPD and healthy control subjects, whereas muscle fiber type I and II proportion was respectively lower (P < .001) and higher (P < .002) in patients with GOLD stage IV compared with healthy subjects and patients with GOLD stages II and III. Exercise training improved, to a comparable degree, functional capacity and the St. George Respiratory Questionnaire health-related quality of life score across all three GOLD stages. Vastus lateralis muscle fiber mean cross-sectional area was increased (P < .001) in all patient groups (stage II: from 4,507 ± 280 μm² to 5,091 ± 271 μm² [14% ± 3%]; stage III: from 3,753 ± 258 μm² to 4,212 ± 268 μm² [14% ± 3%]; stage IV: from 3,961 ± 266 μm² to 4,551 ± 262 μm² [17% ± 5%]), whereas all groups exhibited a comparable reduction (P < .001) in type IIb fiber proportion (stage II: by 6% ± 2%; stage III: by 6% ± 1%; stage IV: by 7% ± 1%) and an increase (P < .001) in capillary to fiber ratio (stage II: from 1.48 ± 0.10 to 1.81 ± 0.10 [23% ± 5%]; stage III: from 1.29 ± 0.06 to 1.56 ± 0.09 [21% ± 5%]; stage IV: from 1.43 ± 0.10 to 1.71 ± 0.13 [18 ± 3%]). The magnitude of changes in the aforementioned variables did not differ across GOLD stages. CONCLUSIONS: Functional capacity and morphologic and typologic adaptations to rehabilitation in peripheral muscle fibers were similar across GOLD stages II to IV. Pulmonary rehabilitation should be implemented in patients at all COPD stages.

Cow's milk (CM) allergy affects about 2% of infants. The allergenicity of dietary proteins, including those from CM, has been related to their digestibility although the generality of the link and its causality remains to be demonstrated. In this study we use an in vitro digestion system, to investigate the digestibility of β-lactoglobulin (blg) during gastrointestinal transit and to assess the impact of this process on blg allergenic reactivity in CM allergic children.|Blg digesta were prepared using an in vitro digestion protocol simulating either gastric digestion alone or followed by duodenal digestion with or without phosphatidylcholine (PC). Biochemical analysis of blg digesta was performed by SDS-PAGE and their concentration was measured by a sandwich ELISA. Assessment of their allergenic reactivity was done in vitro by EAST inhibition, specific basophil activation (basotest) and lymphocyte proliferation (PCNA-flow cytometry) assays using sera and cells from patients allergic to blg and in vivo by skin prick testing (SPT) of these patients.|Blg was only broken down to smaller peptides after gastro-duodenal digestion although a sizeable amount of intact protein still remained. Digestion did not modify the IgE binding capacity of blg except for gastro-duodenal digestion performed in the absence of PC. These results are consistent with the quantity of intact blg remaining in the digesta. Overall both gastric and gastroduodenal digestion enhanced activation of sensitized basophils and proliferation of sensitized lymphocytes by blg. However, there was a tendency towards reduction in mean diameter of SPT following digestion, the PC alone during phase 1 digestion causing a significant increase in mean diameter.|Digestion did not reduce the allergenic reactivity of blg to a clinically insignificant extent, PC inhibiting digestion and thereby protecting blg allergenic reactivity. SPT reactivity was reduced compared to blg immunoreactivity in in vitro tests.

Aims: We investigate the behavior of the frequency-centered light curves expected within the standard model of gamma ray bursts, allowing the maximum electron energy (γmax) to be a free parameter that may take low values. Methods: We solve the spatially averaged kinetic equations that describe the simultaneous evolution of particles and photons, obtaining the multi-wavelength spectra as a function of time. From these we construct the frequency-centered light curves with an emphasis on the X-ray and optical bands. Results: We show that in cases where γmax takes low values, the produced X-ray light curves show a plateau as the synchrotron component gives its place to the synchrotron self-Compton one in the X-ray band.

Aims: We investigate the behavior of the frequency-centered light curves expected within the standard model of gamma ray bursts, allowing the maximum electron energy (γmax) to be a free parameter that may take low values. Methods: We solve the spatially averaged kinetic equations that describe the simultaneous evolution of particles and photons, obtaining the multi-wavelength spectra as a function of time. From these we construct the frequency-centered light curves with an emphasis on the X-ray and optical bands. Results: We show that in cases where γmax takes low values, the produced X-ray light curves show a plateau as the synchrotron component gives its place to the synchrotron self-Compton one in the X-ray band.

Background: In two randomized phase III trials (MM-009 and MM-010), lenalidomide plus dexamethasone significantly prolonged time to progression and overall survival (OS) in patients with relapsed/refractory multiple myeloma compared with dexamethasone alone. In both trials the treatment was continued until disease progression or unacceptable toxicity. We conducted a subanalysis to determine if continuing therapy after achieving ≥ partial response (PR) improved survival. Patients and Methods: Data were collected on 212 patients who were treated with lenalidomide plus dexamethasone and achieved ≥ PR. Kaplan-Meier survival estimates were compared between patients on continued treatment versus patients discontinuing therapy because of adverse events, withdrawal of consent, or other reasons. Time-dependent multivariate regression analyses were used to determine the benefit of continuing treatment with lenalidomide. Results: A total of 174 patients received continued treatment until disease progression or death, and 38 patients discontinued therapy without progression. There was a trend toward longer median OS in patients who continued therapy (50.9 months vs. 35.0 months; P = .0594). When controlling for the number of previous antimyeloma therapies, β2-microglobulin levels, and Durie-Salmon stage (which adversely affected survival in these patients), continued lenalidomide treatment (HR, 0.137; 95% CI, 0.045-0.417; P = .0005) or each additional cycle of lenalidomide (HR, 0.921; 95% CI, 0.886-0.957; P < .0001) were both associated with longer survival. Conclusion: Continued lenalidomide treatment until disease progression after achievement of ≥ PR is associated with a significant survival advantage when controlling for patient characteristics. These findings should be confirmed in a prospectively designed trial. © 2011 Elsevier Inc. All rights reserved.

Objective: Endothelial progenitor cells (EPCs) contribute to the maintenance of endothelial integrity and function. We investigated the effects of rosuvastatin and allopurinol on the number of EPCs in patients with heart failure and aimed to provide insight into the molecular inflammatory and oxidative mechanisms that could be responsible for the alterations in EPC levels after treatment. Methods: Sixty patients with systolic heart failure were randomized to receive rosuvastatin 10mg/d, allopurinol 300mg/d or placebo and followed up for 1 month. The number of CD34 +/KDR + and CD34 +/CD133 +/KDR + EPCs in blood was evaluated by flow cytometry. Endothelial function was assessed by brachial artery flow-mediated dilation. Levels of markers of inflammation and oxidative stress were also determined. Results: Circulating EPCs were significantly increased after rosuvastatin treatment (from 230 (170-380) and 10 (8-24) to 390 (230-520) and 19 (8-33) cells/10 6 lymphomonocytes, respectively, p=0.004 and p=0.008), whereas they remained unchanged in the other groups. The increase in EPC levels was not associated with the changes in the levels of the measured inflammatory and oxidative markers. Conclusion: Short-term treatment with rosuvastatin, but not allopurinol, significantly increases the number of circulating EPCs in patients with heart failure providing further insights into its role in these individuals. The impact of rosuvastatin on EPCs is not mediated by changes in inflammatory and oxidative status. © 2010 Elsevier Ireland Ltd.

This study compared the effects of two different half-squat training programs on the repeated-sprint ability of soccer players during the preseason. Twenty male professional soccer players were divided into 2 groups: One group (S-group) performed 4 sets of 5 repetitions with 90% of their 1-repetition maximum (1RM), and the other group (H-group) performed 4 sets of 12 repetitions with 70% of 1RM, 3 times per week for 6 weeks, in addition to their common preseason training program. Repeated-sprint ability was assessed before and after training by 10 × 6-second cycle ergometer sprints separated by 24 seconds of passive recovery. Maximal halfsquat strength increased significantly in both groups (p < 0.01), but this increase was significantly greater in the S-group compared with the H-group (17.3 ± 1.9 vs. 11.0 ± 1.9%, p < 0.05). Lean leg volume (LLV) increased only in the H-group. Total work over the 10 sprints improved in both groups after training, but this increase was significantly greater in the second half (8.9 ± 2.6%) compared with the first half of the sprint test (3.2 ± 1.7%) only in the S-group. Mean power output (MPO) expressed per liter of LLV was better maintained during the last 6 sprints posttraining only in the S-group, whereas there was no change in MPO per LLV in the H-group over the 10 sprints. These results suggest that resistance training with high loads is superior to a moderate-load program, because it increases strength without a change in muscle mass and also results in a greater improvement in repeated sprint ability. Therefore, resistance training with high loads may be preferable when the aim is to improve maximal strength and fatigue during sprinting in professional soccer players. © 2011 National Strength and Conditioning Association.

This study compared the effects of two different half-squat training programs on the repeated-sprint ability of soccer players during the preseason. Twenty male professional soccer players were divided into 2 groups: One group (S-group) performed 4 sets of 5 repetitions with 90% of their 1-repetition maximum (1RM), and the other group (H-group) performed 4 sets of 12 repetitions with 70% of 1RM, 3 times per week for 6 weeks, in addition to their common preseason training program. Repeated-sprint ability was assessed before and after training by 10 × 6-second cycle ergometer sprints separated by 24 seconds of passive recovery. Maximal halfsquat strength increased significantly in both groups (p < 0.01), but this increase was significantly greater in the S-group compared with the H-group (17.3 ± 1.9 vs. 11.0 ± 1.9%, p < 0.05). Lean leg volume (LLV) increased only in the H-group. Total work over the 10 sprints improved in both groups after training, but this increase was significantly greater in the second half (8.9 ± 2.6%) compared with the first half of the sprint test (3.2 ± 1.7%) only in the S-group. Mean power output (MPO) expressed per liter of LLV was better maintained during the last 6 sprints posttraining only in the S-group, whereas there was no change in MPO per LLV in the H-group over the 10 sprints. These results suggest that resistance training with high loads is superior to a moderate-load program, because it increases strength without a change in muscle mass and also results in a greater improvement in repeated sprint ability. Therefore, resistance training with high loads may be preferable when the aim is to improve maximal strength and fatigue during sprinting in professional soccer players. © 2011 National Strength and Conditioning Association.

This study compared the effects of two different half-squat training programs on the repeated-sprint ability of soccer players during the preseason. Twenty male professional soccer players were divided into 2 groups: One group (S-group) performed 4 sets of 5 repetitions with 90% of their 1-repetition maximum (1RM), and the other group (H-group) performed 4 sets of 12 repetitions with 70% of 1RM, 3 times per week for 6 weeks, in addition to their common preseason training program. Repeated-sprint ability was assessed before and after training by 10 × 6-second cycle ergometer sprints separated by 24 seconds of passive recovery. Maximal halfsquat strength increased significantly in both groups (p < 0.01), but this increase was significantly greater in the S-group compared with the H-group (17.3 ± 1.9 vs. 11.0 ± 1.9%, p < 0.05). Lean leg volume (LLV) increased only in the H-group. Total work over the 10 sprints improved in both groups after training, but this increase was significantly greater in the second half (8.9 ± 2.6%) compared with the first half of the sprint test (3.2 ± 1.7%) only in the S-group. Mean power output (MPO) expressed per liter of LLV was better maintained during the last 6 sprints posttraining only in the S-group, whereas there was no change in MPO per LLV in the H-group over the 10 sprints. These results suggest that resistance training with high loads is superior to a moderate-load program, because it increases strength without a change in muscle mass and also results in a greater improvement in repeated sprint ability. Therefore, resistance training with high loads may be preferable when the aim is to improve maximal strength and fatigue during sprinting in professional soccer players. © 2011 National Strength and Conditioning Association.

OBJECTIVE: Obesity has been implicated in the etiology of postmenopausal breast cancer (PBC). We hypothesized that altered secretion of visfatin may underlie this association. We thus investigated the association of serum visfatin with PBC risk, taking into account known risk factors including adipokines and anthropometric and metabolic parameters. METHODS: In a case-control study, we studied 102 postmenopausal women with pathologically confirmed, incident invasive breast cancer and 102 control women matched on age and time of diagnosis between 2003 and 2010 at Army Share Fund Hospital, Veterans' Hospital (NIMTS). Levels of serum visfatin, adiponectin, leptin, metabolic parameters, carcinoembryonic antigen, and CA 15-3 were determined. RESULTS: The mean serum visfatin level was significantly higher in case than in control participants (P < 0.001). Women in the highest quartile of visfatin concentration presented significantly higher odds for PBC, adjusting for age, date of diagnosis, education, body mass index, waist circumference, years with menstruation, parity/age at first full-term pregnancy, breast-feeding, family history of cancer, use of exogenous hormones, alcohol consumption, smoking status, homeostasis model assessment score, and serum leptin and adiponectin concentrations (odds ratio, 7.93; 95% CI, 2.52-24.9). In case participants, the visfatin level correlated significantly with the tumor marker CA 15-3 (P = 0.03) but not with metabolic and anthropometric variables (P > 0.05). CONCLUSIONS: Further prospective studies are needed to determine whether an elevated serum visfatin level is implicated in the etiopathogenesis of PBC or reflects changes during PBC progression and could therefore be used as a biomarker for PBC.

Introduction: Waldenström's macroglobulinemia (WM) is a rare but distinct B-cell lymphoproliferative disorder characterized by lymphoplasmacytic bone marrow infiltration and IgM monoclonal paraproteinemia. Alkylators or nucleosides analogs, often in combination with rituximab, are the most commonly used drugs, but WM will relapse and even salvage treatments may fail. Areas covered: We present recent advances on the treatment of WM, focusing on drugs that are under clinical investigation and for which data indicate promising activity and positive future prospects. Bortezomib is a proteasome inhibitor that eventually becomes a major treatment option for WM. Everolimus and perifosine which target mTOR (mammalian target of rapamycin) and Akt, respectively, of the PI3K/AKT/mTOR pathway showed some activity. Bendamustine, a novel alkylating agent is active, especially in combination with rituximab. Immunomodulatory drugs can act synergistically with rituximab but are toxic. Targeting surface antigens of the lymphoplasmatic cells have shown promising results. Expert opinion: Combinations of novel drugs with established agents are feasible and increase response rates but whether there will be an increase in the survival of patients with WM needs further investigation. The toxicity profile is an important determinant for the feasibility of these drugs in patients with WM. © 2011 Informa UK, Ltd.

Encouraging progress has been made in the treatment of patients with relapsed/refractory multiple myeloma (MM). The rapidly evolving understanding of key pathways responsible for tumor growth and survival has led to the development of novel agents (including immunomodulatory drugs, proteasome inhibitors, histone deacetylase inhibitors, and other targeted agents) with the potential to provide significant improvements in response and survival, and influence treatment guidelines. This review summarizes recent advances in understanding of the biology of relapsed/refractory MM and clinical trials with novel targeted agents that are currently under investigation for patients with this disease. © 2010 John Wiley & Sons A/S.

The objective of this study is to examine the synergistic environmental impacts (thermal bioclimatic conditions and air quality due to particulate pollution) with cardiovascular and respiratory syndromes, in Heraklion in the northern part of Crete Island, during a Saharan dust episode on March 22-23, 2008. Daily counts of admissions for cardiovascular and respiratory syndromes were obtained from the two main hospitals in Heraklion. The corresponding daily meteorological parameters, such as maximum and minimum air temperature, relative humidity, wind speed and cloud cover, from the meteorological station of Heraklion (Hellenic National Meteorological Service), were processed in order to estimate and analyze the bioclimatic conditions expressed by the Physiologically Equivalent Temperature (PET), which is based on the energy balance models of the human body. Dust concentrations were derived from the SKIRON forecast model of the University of Athens, while Moderate Resolution Imaging Spectroradiometer (MODIS) products such as aerosol optical depth at 550 nm (AOD550), aerosol small mode fraction (SM), Ångström exponent in the 550-865 nm band and mass concentration, were used for the episode. Besides, daily composite anomalies (reference period: 1968-1996) of the air temperature and vector wind from the middle to the lower atmospheric levels (500 hPa - mean sea level) on March 23, 2008, were calculated from the reanalysis datasets of the National Centers for Environmental Prediction/National Center for Atmospheric Research (NCEP/NCAR). The analysis of MODIS and SKIRON products showed that high AOD 550 values (>0.9) and high dust concentration (>250 μg/m 3), respectively, appear on March 23, 2008, while the respiratory admissions were five-fold than the mean daily admissions on the same day of the emergence of the Saharan dust episode (key day). According to the analysis, this is due to the existence of coarse-mode particles along the dust pathway, which trigger respiratory syndromes more than cardiovascular, which are associated more with ultra-fine particles. The admissions concerning the cardiovascular syndromes did not appear any significant change. The analysis of the bioclimatic conditions on the key day revealed that moderate thermal stress existed and this may be attributed mainly to the geomorphology of the island, which is responsible for special weather conditions such as Fohn winds. The drier atmospheric conditions, as a result of strong, desiccating winds on the leeward side of the mountains, contribute more to the already high hospital admissions for respiratory symptoms. © Gebrüder Borntraeger, Stuttgart 2011.

BACKGROUND: Basal cell carcinoma (BCC) is the most common form of skin cancer with increasing incidence rates worldwide. METHODS: To assess the association of BCC with epidemiologic risk factors in a Southern European population from Greece, we conducted a hospital-based case-control study of 199 patients with BCC and 200 controls. RESULTS: In the multivariate analysis, fair skin colour was associated with increased risk of BCC (OR: 4.9, 95% CI: 2.4-10.0). However, darker skin phototypes III/IV (patient's reported sun sensitivity/tanning ability) showed a higher BCC risk (OR: 3.9, 95% CI: 1.8-8.5). Persons with occupational UV exposure of 5 years or more had a 2.7-fold increased risk (95% CI:1.4-5.3). There was an increased risk of BCC related to the number of sunburns after the age of 20 years (OR: 3.2, 95% CI: 1.4-7.3) and solar lentigines (OR: 6.8, 95% CI: 3.6-12.8). Subgroup analysis showed that different risk factors are associated with early onset BCC including the presence of dysplastic nevi (OR: 6.4, 95% CI: 1.5-27.2), the number of weeks per year spent at the beach during childhood (OR: 8.9, 95% CI: 3.3-24.1) and the history of sunburns during childhood (OR:5.0, 95% CI: 1.3-19.1). CONCLUSIONS: Fair skin colour was significantly associated with BCC risk. The relation of sunburns during adulthood with BCC underlies the importance of sunburn prevention throughout life time. Early onset BCCs seem to have a different pathogenetic background and were associated with dysplastic nevi as well as intermittent sun exposure and sunburns during the early years of life.

In order to investigate differences among infections due to Gram-negative anaerobic bacteria (Bacteroides, Prevotella and Fusobacterium spp.), clinical, epidemiological, and microbiological data were collected and evaluated from 206 anaerobic infections. The most frequently isolated species was Bacteroides fragilis. The majority of the cases were intra-abdominal infections (49%) followed by skin and soft tissue infections (24.7%). Logistic regression analysis showed that Bacteroides spp. strains were more often isolated from intra-abdominal infections (p = 0.002), whereas Prevotella spp. were isolated more frequently from cases with shorter duration of hospitalization (p = 0.026), and less frequently from bloodstream infections (p = 0.049). In addition, Bacteroides spp. were associated with coinfection due to Enterobacteriaceae species (p = 0.007), whereas Prevotella spp. were associated with coinfection due to Staphylococcus spp. (p = 0.002). Patients with an infection due to B. fragilis, were more frequently admitted in a general surgical ward (p = 0.017), or have been treated with a 2nd generation cephalosporin before anaerobic infection onset (p = 0.05). Total mortality was 10.9% and was associated with bacteremia (p = 0.026), and hematological (p = 0.028), or solid organ malignancy (p = 0.007). Metronidazole resistance was detected only among Prevotella spp. (16.2%) and B. fragilis group (0.8%) isolates. In conclusion, this study indicated differences between infections due to the most frequently isolated Gram-negative anaerobic species, differences that may affect the design and implementation of empirical antimicrobial chemotherapy guidelines.

In our discussion of electronic parameters for charge (hole or electron) transfer along DNA we have omitted to mention that, regarding the tight-binding description of hole transport, the corresponding tight-binding parameters should be taken with the opposite sign of the calculated on-site energies and transfer hopping integrals. This means that for describing hole transport at the base-pair level, the on-site energies EbpH presented in the second row of table 2 and the hopping transfer integrals tbpH presented in the second column of table 3 should be used with opposite signs in order to provide the tight-binding parameters of eq. (10). Similarly, for describing hole transport at the single-base level, the on-site energies EbH presented in the eleventh row of table 1 and the hopping transfer integrals tbH presentedin the second column of tables 4–7 should be used with opposite signs in order to provide the tight-binding parameters of eq. (13). Moreover, on p. 300, 8 lines below eq. (14), in the calculation of charge transfer hopping parameters the separation between adjacent base-pairs in B-DNA should read 3.4 ̊A, instead of 3.14 ̊A.

Patients with advanced multiple myeloma (MM) often have increased osteolytic activity of osteoclasts and impaired osteogenesis by osteoblasts, resulting in osteolytic bone lesions that increase the risk of skeletal-related events (SREs) including pathologic fracture, the need for radiotherapy or surgery to bone, and spinal cord compression. Such SREs are potentially life-limiting, and can reduce patients' functional independence and quality of life. Bisphosphonates (e.g., oral clodronate and intravenous pamidronate and zoledronic acid) can inhibit osteoclast-mediated osteolysis, thereby reducing the risk of SREs, ameliorating bone pain, and potentially prolonging survival in patients with MM. Extensive clinical experience demonstrates that bisphosphonates are generally well tolerated, and common adverse events are typically mild and manageable. Studies are ongoing to optimize the timing and duration of bisphosphonate therapy in patients with bone lesions from MM. © 2011 Elsevier Ireland Ltd.

BACKGROUND: The aim of this study was to assess the disease burden of the 2009 pandemic influenza A(H1N1) in Greece. METHODOLOGY/PRINCIPAL FINDINGS: Data on influenza-like illness (ILI), collected through cross-sectional nationwide telephone surveys of 1,000 households in Greece repeated for 25 consecutive weeks, were combined with data from H1N1 virologic surveillance to estimate the incidence and the clinical attack rate (CAR) of influenza A(H1N1). Alternative definitions of ILI (cough or sore throat and fever>38 degrees C [ILI-38] or fever 37.1-38 degrees C [ILI-37]) were used to estimate the number of symptomatic infections. The infection attack rate (IAR) was approximated using estimates from published studies on the frequency of fever in infected individuals. Data on H1N1 morbidity and mortality were used to estimate ICU admission and case fatality (CFR) rates. The epidemic peaked on week 48/2009 with approximately 750-1,500 new cases/100,000 population per week, depending on ILI-38 or ILI-37 case definition, respectively. By week 6/2010, 7.1%-15.6% of the population in Greece was estimated to be symptomatically infected with H1N1. Children 5-19 years represented the most affected population group (CAR:27%-54%), whereas individuals older than 64 years were the least affected (CAR:0.6%-2.2%). The IAR (95% CI) of influenza A(H1N1) was estimated to be 19.7% (13.3%, 26.1%). Per 1,000 symptomatic cases, based on ILI-38 case definition, 416 attended health services, 108 visited hospital emergency departments and 15 were admitted to hospitals. ICU admission rate and CFR were 37 and 17.5 per 100,000 symptomatic cases or 13.4 and 6.3 per 100,000 infections, respectively. CONCLUSIONS/SIGNIFICANCE: Influenza A(H1N1) infected one fifth and caused symptomatic infection in up to 15% of the Greek population. Although individuals older than 65 years were the least affected age group in terms of attack rate, they had 55 and 185 times higher risk of ICU admission and CFR, respectively.

We theoretically and numerically analyze a five-layer "trapped rainbow" waveguide made of a passive negative refractive index (NRI) core layer and gain strips in the cladding. Analytic transfer-matrix calculations and full-wave time-domain simulations are deployed to calculate, both in the frequency and in the time domain, the losses or gain experienced by complex-wave-vector and complex-frequency modes. We find excellent agreement between five distinct sets of results, showing that the use of evanescent pumping (gain) can compensate the losses in the NRI slow- and stopped-light regimes. © 2011 American Physical Society.

Background and Objectives Follow up for breast cancer patients aims at the timely detection of loco-regional recurrences and contralateral breast cancers (LRR). This study investigates the annual risk of LRR after breast conserving treatment (BCT) and the potential value of mammographic surveillance and/or routine clinical examination. Methods Data on 650 women who underwent BCT were obtained and LRR was divided into parenchymal and non-parenchymal. LRR-free and cumulative LRR-free rates were calculated. In patients where recurrence was diagnosed at a routine clinic visit and had negative mammography ("clinical detection only" group) were also separately examined. Results Median follow up was 115 months, range 9-196. Seventy-three patients had parenchymal and 16 nodal recurrence. The median probability of LRR was 1.4% and of parenchymal LRR was 1.32% per year, remaining constant for up to 168 months. The 16 patients in the "clinical detection only" group relapsed mainly during the first 2 years (annual risk 0.77% and 0.80%, respectively). Conclusions This study shows that the risk of parenchymal LRR remains constant for at least 14 years and is significant enough to warrant routine long-term follow up mammography. Routine clinical examination contributes significantly to the detection of LRR only for the first 2 years. © 2011 Wiley-Liss, Inc.

Allergic rhinitis (AR) and chronic idiopathic urticaria (CIU) are highly burdensome diseases, which are increasing in prevalence, especially in the paediatric population. Despite the availability of a large number of medications for treatment of AR and CIU, their use in children has primarily been based on data obtained from a limited number of clinical trials in children and/or testing in adults. The H(1)-antihistamines have traditionally been used as first-line treatment for the relief of both AR and CIU symptoms in children. The first-generation H(1)-antihistamines are associated with marked adverse effects such as sedation, sleepiness/drowsiness as well as difficulties in learning and cognitive processing; thus, they are recommended for limited or discontinued use in children with AR or CIU. In contrast, second-generation H(1)-antihistamines are more adapted for the use in children with AR and CIU due to better safety profiles. However, only a limited number of trials with these agents have been conducted and generally, data from well-designed trials in children are lacking. Levocetirizine is one of the most extensively investigated H(1)-antihistamines for its pharmacologic properties, safety, efficacy as well as overall global satisfaction in children aged 2-12 years. Levocetirizine is the only H(1)-antihistamine launched in the 21st century shown to lack clinically relevant adverse effects on physical and psychomotor development or routine laboratory tests over a long-term period of 18 months in 1- to 3-year-old children predisposed to development of allergic disease. Available data suggest that levocetirizine is a suitable treatment option for AR and CIU in children aged 6 months to 12 years.

BACKGROUND: The effectiveness of a new delivery system consisting of polymerized dilactide (PLA) with incorporated linezolid was investigated in a rabbit model as a means of treating methicillin-resistant Staphylococcus aureus (MRSA) osteomyelitis. METHODS: The PLA-linezolid system was prepared after thorough stirring of PLA with linezolid at a 10:1 ratio. Experimental osteomyelitis was established in 40 rabbits by a modification of the Norden model with MRSA as the test isolate. After a hole had been drilled in the upper right femur, the isolate was inoculated using a thin needle working as a foreign body. At three weeks, the needle was removed and cultured, and the PLA-linezolid system was implanted in half the animals (group B); the remaining half was the control group (group A). Animals were sacrificed at regular intervals; tissue around the site of implantation was examined for pathologic changes and cultured quantitatively. RESULTS: The prepared system eluted linezolid in vitro at concentrations much greater than the minimum inhibitory concentration (MIC) of the test pathogen for 11 days. At three weeks after inoculation of the test isolate, all animals had osteomyelitis. By the sixth week, bacterial growth from cancellous bone of group B was significantly lower than that in group A. However, this effect was not maintained until the end of the study (weeks 8 and 10), when the differences in bacterial growth in the two groups were not significant. CONCLUSION: Polymerized dilactide mixed with 10% linezolid achieved partial arrest of the offending pathogen in an experimental model of osteomyelitis caused by MRSA.

C-C motif ligand 3 (CCL3) chemokine plays a crucial role in the inflammation process, cell migration and chemoattraction of monocytes/ macrophages, neutrophils and mast cells. CCL3 is overexpressed by malignant cells in B-cell disorders, including chronic lymphocytic leukemia and multiple myeloma. Elevated circulating CCL3 was previously described in Waldenström's macroglobulinemia (WM) but the source of its production was unknown. We performed an immunohistochemical study in bone marrow biopsies of 67 WM patients and found that the whole number of the neoplastic cells express CCL3 in all cases. This finding was constant in newly diagnosed patients with both symptomatic and asymptomatic WM and also in patients with active disease post previous therapies. Our results support, for the first time in the literature, the production of CCL3 by WM cells. They also suggest a possible role of CCL3 in WM biology and reveal CCL3 as a potential target for developing novel drugs against WM. © 2011 Elsevier Inc. All rights reserved.

We investigate the uniform limits of the set of polynomials on the closed unit disc D&#xAF;"> with respect to the chordal metric χ. More generally, we examine analogous questions replacing the one-point compactification of CC&#x222A;{&#x221E;}"> by other metrizable compactifications.

INTRODUCTION: The aim of this study was to assess the changes in inclination of the maxillary second (M2) and third (M3) molars after orthodontic treatment of Class II Division 1 malocclusion with extraction of maxillary first molars. METHODS: Two groups of subjects were studied. The experimental group consisted of 37 subjects, 18 boys and 19 girls (mean age, 13.2 ± 1.62 years). The inclusion criteria were white origin, Class II Division 1 malocclusion, overjet ≥4 mm, no missing teeth or agenesis, and maxillary M3 present. All patients were treated with extraction of the maxillary first molars and the Begg technique. Standardized lateral cephalometric radiographs were taken at the start of active treatment (T1) and at least 3.7 years posttreatment (T2). The control group was drawn from the archives of the Nittedal Growth Material (Oslo University, Oslo, Norway) and included 54 untreated Class I and Class II subjects,18 boys and 36 girls (mean age, 13.4 ± 1.99 years) followed up for a minimum of 3.6 years. M2 and M3 inclinations relative to the palatal plane (PP) and functional occlusal plane (FOP) were measured and compared between groups and time periods. RESULTS: M2 to PP inclination improved significantly in both the control group (M2-PP at T1, 17.7° ± 5.81°, and at T2, 11.9° ± 4.61°) and the experimental group (M2-PP at T1, 26.7° ± 5.75°, and at T2, 6.9° ± 6.76°). There were also significant increases of the mesial inclination of M3 in the control group (M3-PP at T1, 30.1° ± 8.54°, and at T2, 19.6° ± 9.01°) and extraction group (M3-PP at T1, 32.2° ± 7.90°, and at T2, 12.8° ± 7.36°). By using the FOP as the reference system, no significant change in the inclination of M2 was observed in the control group, whereas, in the extraction group, although more distally inclined at T1, M2 ended up mesially inclined at T2 (M2-FOP at T1, 14.2° ± 4.62°, and at T2, -6.2° ± 6.10°; P <0.0001). M3 inclinations were similar between the groups at T1 (M3-FOP control, 17.3° ± 9.35°; M3-FOP experimental, 19.6° ± 7.37°), and these improved significantly in both groups. However, M3 uprighting was almost 4 times greater in the extraction group (M3-FOP from T2-T1, 5.6° vs 19.9°). The greatest distal inclination of M3 at T2 in the extraction group was 9.4°, a value attained by only 43% of the control group. CONCLUSIONS: Extraction of the maxillary first molars in Class II Division 1 patients results in significant uprighting of M2 and M3 and facilitates the normal eruption of M3.

Launching the distance-learning student-tutor interaction process, tutors of the first module of the M.Ed in English course at the HOU lay the foundations of academic student autonomy by means of providing – inter alia -- the appropriate written feedback on written assignments. In doing so, they need to gauge the content and form of their written comments systematically with regard to both output- and student-, that is human factor-related issues (cf. Goldstein, 2004), the latter being particularly relevant to the distance-learning context. In this article we discuss tutor policy as well as tutor perceptions (cf. Lee, 2004, 2009 among others) regarding written feedback on students’ academic assignments in terms of aspects of deviance treated and the relative gravity of ‘global’ and ‘local’ errors (e.g. Ferris, 2002), the directness of the correction, the punitive or facilitative nature of the comments provided as well as the relative balance of student strengths and weaknesses on the tutor’s comment agenda (cf. Hyland & Hyland, 2006). The role of the tutor as an assessor and/or counsellor is explored and the importance of striking a delicate balance between the two, especially in a context where face-to-face feedback opportunities are severely restricted, is underscored. We suggest that distance-learning feedback practices may need to be at least partially individualized to maximize student response and meet the goal of ‘informed autonomy’.

The highly oriented filamentous protein network of muscle constantly experiences significant mechanical load during muscle operation. The dimeric protein myomesin has been identified as an important M-band component supporting the mechanical integrity of the entire sarcomere. Recent structural studies have revealed a long alpha-helical linker between the C-terminal immunoglobulin (Ig) domains My12 and My13 of myomesin. In this paper, we have used single-molecule force spectroscopy in combination with molecular dynamics simulations to characterize the mechanics of the myomesin dimer comprising immunoglobulin domains My12-My13. We find that at forces of approximately 30 pN the alpha-helical linker reversibly elongates allowing the molecule to extend by more than the folded extension of a full domain. High-resolution measurements directly reveal the equilibrium folding/unfolding kinetics of the individual helix. We show that alpha-helix unfolding mechanically protects the molecule homodimerization from dissociation at physiologically relevant forces. As fast and reversible molecular springs the myomesin alpha-helical linkers are an essential component for the structural integrity of the M band.

In this paper we propose a feature-based analysis of Cappadocian Greek nominal inflection. In particular, based on the formal description of Standard Greek nominal inflection by Ralli (2000), we identify the inflectional formatives and analyse them as bundles of features expressing number, case, animacy and inflectional class. The feature specification of each ending determines its distribution in the relevant variety. Similarly, inflectional classes are defined on the basis of (a) the compatibility of a given noun with an inflectional pattern and (b) the base alternations it exhibits. Such an approach has the advantage of accounting for the variation in base formation and for the agglutinative inflectional patterns by means of systematic base allomorphy and default formatives.

For a nitrogen dimer in insulating MgO, a ferromagnetic coupling between spin-polarized 2p holes is revealed by calculations based on the density functional theory amended by an on-site Coulomb interaction and corroborated by the Hubbard model. It is shown that the ferromagnetic coupling is facilitated by a T-shaped orbital arrangement of the 2p holes, which is in its turn controlled by an intersite Coulomb interaction due to the directionality of the p orbitals. We thus conjecture that this interaction is an important ingredient of ferromagnetism in band insulators with 2p dopants.

Objectives: Bone disease is a key presenting feature of myeloma. This post hoc analysis of the phase III VISTA trial of bortezomib plus melphalan-prednisone (VMP) vs. MP in previously untreated myeloma patients assessed clinical bone disease events and changes in alkaline phosphatase (ALP), a marker for osteoblast activation, and serum Dickkopf-1 (DKK-1), an inhibitor of osteoblast differentiation, during treatment. Methods: Patients received nine 6-wk cycles of VMP (bortezomib 1.3mg/m 2, days 1, 4, 8, 11, 22, 25, 29, 32, cycles 1-4, days 1, 8, 22, 29, cycles 5-9, plus melphalan 9mg/m 2 and prednisone 60mg/m 2, days 1-4, cycles 1-9; N=344) or MP alone (N=338). Results: Rates of bisphosphonates use during treatment (73% vs. 82%), progression because of worsening bone disease (3% vs. 11%), and requirement for subsequent radiotherapy (3% vs. 8%) were lower with VMP vs. MP. Median maximum ALP increase was significantly higher with VMP vs. MP overall (49.7% vs. 30.3%, P=0.029), and higher by response group (complete response [CR]: 68.7% vs. 43.9%; partial response [PR]: 41.5% vs. 31.2%). Greater maximum ALP increase was strongly associated with achievement of CR (P≤0.0001) and CR/PR (P≤0.01). Median DKK-1 decreased with VMP by 694.4pg/mL and increased with MP by 1273.3pg/mL from baseline to day 4 (P=0.0069). Available radiologic data revealed evidence of bone healing in 6/11 VMP-treated patients, who achieved best responses of three CR, one PR, and two stable disease. Conclusions: These results suggest a positive effect of bortezomib on bone metabolism and potentially bone healing in myeloma. © 2011 John Wiley and Sons A/S.

On the occasion of the tenth anniversary of the Μ.Ed. in TESOL programme of the Hellenic Open University, we distributed a questionnaire to graduates as well as current students of the programme. Our primary goal was to further reflect on the usefulness of the programme ten years after and identify possible weak points that need enhancement for the ultimate benefit of our students and the Greek society at large. To that end, we aimed to map out students’ views about the programme and its influence on their professional life. In the various sections of the questionnaire we tried to explore (a) whether their expectations are fulfilled; (b) which modules of those on offer they have selected and which they consider as the most and least important for their professional training and development; (c) how the programme has influenced the professional choices they make/have made outside teaching a class-proper; (d) whether they regard the programme as a springboard for further professional development which they can embark upon on their own; (e) what suggestions they can make for the programme’s further improvement of. The results were very positive. The goals we had set forth in 1998, when this Μ.Ed. in TESOL teacher education programme was inaugurated, were definitely fulfilled for the benefit of the teachers of English at large both in the private and the state sector. The work that has been carried out so far points to a bright future, provided we continue on the same successful course and implement all necessary changes and adjustments required by our changing times.

We prospectively studied 110 consecutive patients with intertrochanteric hip fractures treated with the 130 degree angle, 10-mm short IMHS intramedullary hip screw (IMHS, Smith & Nephew, Richards, Memphis, TN). Surgery was performed within 36 hours from admission; all patients were mobilized immediately postoperatively. Fracture union, pre- and post-operative mobility status and complications were evaluated. Eighty patients were included in the postoperative evaluation for a mean followup of 14 (range, 9 to 25) months. Mortality was 19%. Union occurred in 79 fractures within 6 months from surgery; there was one case of screw cut-out and one case of deep venous thrombosis. Periprosthetic femoral shaft fractures were not observed. At the latest examination, the mean mobility score decreased from 8.4 +/- 1.6 to 7.1 +/- 2.1 (p = 0.0001); 26 patients (32%) fully achieved the preoperative mobility score and 54 patients (68%) achieved more than 90% of the preoperative mobility score. The IMHS intramedullary hip screw represents a reliable method for the treatment of patients with intertrochanteric hip fractures, and provides for early mobilization and rehabilitation of the patients with acceptable complications.

This research applies the fuzzy set theory via Geographical Information Systems (GIS) - based analysis to investigate the slope erosion by water. The main steps of this procedure are the definition of the input variables (rocks’ susceptibility to erosion, slope angle, slope morphology), the development of a fuzzy inference system based on theoretical and empirical knowledge, transforming the input to output variables (erosion – deposition) and the visualization of the output variables (spatial distribution of the erosion-deposition processes). The method was applied at the Corinth drainage basin, located in the north-eastern part of Peloponnese (Greece), where a series of catastrophic erosional events have recently occurred.

Photonic metamaterials allow for a range of exciting applications unattainable with ordinary dielectrics. However, the metallic nature of their meta-atoms may result in increased optical losses. Gain-enhanced metamaterials are a potential solution to this problem, but the conception of realistic, three-dimensional designs is a challenging task. Starting from fundamental electrodynamic and quantum mechanical equations, we establish and deploy a rigorous theoretical model for the spatial and temporal interaction of lightwaves with free and bound electrons inside and around metallic (nano-) structures and gain media. The derived numerical framework allows us to self-consistently study the dynamics and impact of the coherent plasmon-gain interaction, nonlinear saturation, field enhancement, radiative damping and spatial dispersion. Using numerical pump-probe experiments on a double-fishnet metamaterial structure with dye molecule inclusions, we investigate the build-up of the inversion profile and the formation of the plasmonic modes in a low-Q cavity. We find that full loss compensation occurs in a regime where the real part of the effective refractive index of the metamaterial becomes more negative compared to the passive case. Our results provide a deep insight into how internal processes affect the overall optical properties of active photonic metamaterials fostering new approaches to the design of practical, loss-compensated plasmonic nanostructures. © 2011 The Royal Society.

We outline the theory of slow-light propagation in waveguides featuring negative electromagnetic parameters (permittivity, permeability and/or refractive index). We explain the mechanism by which these heterostructures can enable stopping of light even in the presence of disorder and, simultaneously, dissipative losses. Using full-wave numerical simulations and analytical transfer-matrix calculations we show that the incorporation of thin layers made of an active medium adjacently to the core layer of a negative-refractive-index waveguide can completely remove dissipative losses - in a slow- or stopped-light regime where the effective index of the guided lightwave remains negative. We also review and compare several 'trapped rainbow' schemes that have recently been proposed for slowing and stopping waves. © 2011 SPIE.

During cortical development, coordination of proliferation and differentiation ensures the timely generation of different neural progenitor lineages that will give rise to mature neurons and glia. Geminin is an inhibitor of DNA replication and it has been proposed to regulate cell proliferation and fate determination during neurogenesis via interactions with transcription factors and chromatin remodeling complexes. To investigate the in vivo role of Geminin in the maintenance and differentiation of cortical neural progenitors, we have generated mice that lack Geminin expression in the developing cortex. Our results show that loss of Geminin leads to the expansion of neural progenitor cells located at the ventricular and subventricular zones of the developing cortex. Early cortical progenitors lacking Geminin exhibit a longer S-phase and a reduced ability to generate early born neurons, consistent with a preference on self-renewing divisions. Overexpression of Geminin in progenitor cells of the cortex reduces the number of neural progenitor cells, promotes cell cycle exit and subsequent neuronal differentiation. Our study suggests that Geminin has an important role during cortical development in regulating progenitor number and ultimately neuron generation.

Digital Assembly presentation, Brussels  June 17, 2011-------------------------------------------------------------------------------------------------------------------------------------------------- How can we move from gender devaluation and gender fatigue to gender energy and get more women to ride up the glass escalator? Current research indicates the need to focus on innovative approaches to getting gender back onto the agenda: reproducing women’s recruitment, retention, advancement and agency (Farrington 2011, Kamberidou 2010, Kelan 2010, Merriman 2010, Benschop & Brouns 2003, Hultin 2003). Despite legislation and gender mainstreaming policies, the recognition by many companies, organizations and institutions that diversity is essential, women still lag behind men in compensation and advancement and are less satisfied with their careers than men. Women are overlooked in decision making positions in the business sector, in S&R, in the academia, on research committees, etc. This paper examines three major gender gaps: 1) the leadership gap, 2) the pay gap and 3) the engagement/participation gap, with references to the phenomena of gender fatigue, tokenism and the hidden advantages for men in the so-called 'female' professions. Taking their gender privilege with them, men experience positive discrimination in female dominated professions and are promoted up the ladder (ride up the glass escalator) even faster than their female counterparts, as opposed to women who confront the glass ceiling and the sticky floor in male dominated fields. Gender devaluation, namely the subtle processes by which women’s contributions are minimized, undervalued or devalued in male dominated professions are especially apparent in the academia as well. Consequently, "getting gender back on the agenda" (Kamberidou 2010) requires an Alternative Model—redefining professional success and concepts of excellence, finding alternative paths to advancement or tenure, establishing measures and best practices at many levels—examined in the strategy proposals presented in this paper. Research shows that women are an economic force to be reckoned with and utilizing the entire talent provides an important competitive advantage. Studies confirm that companies that recognise talent in any form and make good use of it show greater success with regard to profits and sustainability. Women must be present in sufficient numbers at senior levels in order to achieve better results and especially to drive cultural change.   Keywords: gender fatigue, the ‘stupid curve’: wastage of talent, the glass escalator, tokenism, gender devaluation, gender-blind academic structures      

Zymomonas mobilis ATCC 10988 is the type strain of the Z. mobilis subsp. mobilis taxon, members of which are some of the most rigorous ethanol-producing bacteria. Isolated from Agave cactus fermentations in Mexico, ATCC 10988 is one of the first Z. mobilis strains to be described and studied. Its robustness in sucrose-substrate fermentations, physiological characteristics, large number of plasmids, and overall genomic plasticity render this strain important to the study of the species. Here we report the finishing and annotation of the ATCC 10988 chromosomal and plasmid genome.

Zymomonas mobilis is an alphaproteobacterium studied for bioethanol production. Different strains of this organism have been hitherto sequenced; they all belong to the Z. mobilis subsp. mobilis taxon. Here we report the finished and annotated genome sequence of strain ATCC 29192, a cider-spoiling agent isolated in the United Kingdom. ATCC 29192 is the lectotype of the second-best-characterized subspecies of Z. mobilis, Z. mobilis subsp. pomaceae. The nucleotide sequence of ATCC 29192 deviates from that of Z. mobilis subsp. mobilis representatives, which justifies its distinct taxonomic positioning and proves particularly useful for comparative and functional genomic analyses.

Cette contribution au volume consacré à l’identité féminine dans l’oeuvre d’Elsa Triolet tente de décrypter la pensée « féministe » de l’auteure à travers ses écrits personnels et autobiographiques, ses articles et reportages, les discours également prononcés dans le cadre des manifestations organisées par l’Union des Femmes Françaises. Dans une première partie sont examinées ses conceptions sur les rapports des sexes. Triolet réfute haut et fort la supériorité des hommes sur les femmes et condamne la ségrégation des sexes. Selon l’auteure l’être humain n’est pas fait que de « féminin » ou que de « masculin ». La société devrait être donc construite à l’image de cet être mixte : elle prône alors un univers bisexué, un langage aussi dans lequel les deux sexes seraient visibles. Pour y arriver, elle invite à un « féminisme individuel », un féminisme quotidien. C’est qu’elle rejette l’idée de la mobilisation collective des femmes : à son sens, cette forme de lutte représente une autre manifestation du « ghetto » qu’elle abhorre. Fidèle à ces convictions, elle choisit de promouvoir des causes qui s’inscrivent dans le cadre plus large de l’action des intellectuelles de gauche proches du PCF. Dans la deuxième partie, il est question de son engagement dans la Résistance. Au cours de cette période de sa vie, Triolet se soumet en apparence à la répartition sexuée des rôles. Le « je » féminin recouvre ses droits dans ses seuls écrits portant sur cette période : moment transitionnel, la guerre bouleverse les équilibres et les assignations, brouille les identités. Ces textes participent ainsi à la construction d’une mémoire communiste de la Résistance au féminin. La troisième partie est consacrée au combat de Triolet, compagnon de route du PCF, contre l’invasion d’une culture américaine en France. En pleine guerre froide, l’auteure ne dissocie pas la lutte en faveur d’une littérature « progressiste » de celle pour la paix : les femmes pourraient contribuer à la propagation de cette culture, seule arme contre la guerre. Fidèle à la ligne du Parti, elle ne cesse de valoriser - quand l’Union des Femmes Françaises fait appel à elle – cet aspect du rôle social féminin. Pour expliquer la propension des hommes à la guerre, elle a recours au schéma nature/culture : elle considère que seule la paix est conforme à la nature des deux sexes, le bellicisme étant ainsi présenté comme une construction sociale ; or, la nature masculine n’est pas perméable au conditionnement social, d’où la supériorité naturelle des femmes dont la présence dans la sphère publique constitue, de ce fait, une condition indispensable au progrès humain.L’errance à travers les textes d’Elsa Triolet conduit donc à la constatation que sa pensée « féministe » se forme sous le signe de la contradiction due aussi à son appartenance politique : adhésion à un féminisme de l’égalité dans son discours introspectif mais, dans la sphère publique, promotion du différentialisme sexuel ; lutte individuelle pour l’égalité avec les hommes et, parallèlement, rejet d’une action féministe collective au nom d’une société mixte et égalitaire.

A B S T R A C THow genres can be used to enhance pragmatic competence is an issue not adequately explored. Pragmatic competence is defined in this paper as a twofold ability relying on two types of competence: (a) pragmatic awareness, i.e. the ability to correctly identify pragmatically inferred effects in the form of implicated conclusions, e.g. irony, humour, contempt, respect, favouring, or incriminating attitudes conveyed by different text-types, and (b) metapragmatic awareness, the ability to meta-represent and explicate the link between relevant linguistic indexes and pragmatic effects retrieved by readers. Results from non-native university learners of English indicate that explicit genre-based instruction has significant positive effects on the development of genre-focused, convention-specific discourse but not on the development of pragmatic competence in low-level language proficiency learners. A positive correlation between language proficiency and pragmatic competence is further consolidated by the data.

Methane Hydrates are a new energy resource in the global energy market which has received extreme attention from a technological and geopolitical point of view. The reserve estimates exceed by far the overall estimates of all the other conventional energy reserves. With the existing technological know-how the exploitation of methane hydrates is expected to dominate the international energy market within the next 10-15 years. Methane hydrates have been mapped within the Hellenic Submarine Space and especially in the region of Kastellorizo, with whatever consequences it may have of geostrategic nature for the political decisions of Greece and its relations with the neighbouring countries and the delimitation of its EEZ.

In Greece, there is no officially organized training in clinical chemistry for scientists. The Greek Society of Clinical Chemistry-Clinical Biochemistry (GSCC-CB), following the encouragement of the EC4/RC decided to organize a voluntary Register for specialists in clinical chemistry. The following criteria for registration were defined: 1) University degree in Chemistry, Biochemistry, Biology, Medicine, Pharmacy or other relevant subject. 2) A total of 9 years of university studies and postgraduate specialization in clinical chemistry-clinical biochemistry. 3) A minimum of 4 years of postgraduate specialization in clinical chemistry-clinical biochemistry on the job. 4) The candidate must be practicing clinical chemistry-clinical biochemistry in a laboratory in a medical environment in Greece. The postgraduate specialization in clinical chemistry-clinical biochemistry includes the laboratory training and the theoretical education. The laboratory training is organized by the GSCC-CB according to the Professional Training Dossier. The theoretical education was organized in a series of 18 "Seminars" which was the content of the "Educational program" of the GSCC-CB. Successful completion of the Educational program leads to a Certificate of Competence. The Greek Register has gained equivalence with the EC4 Register and it has 218 members, more than 80 of whom are European clinical chemists. © 2011 by Walter de Gruyter.

Ζούμε σε έναν κόσμο που γίνεται όλο και πιο σύνθετος, πολύπλοκος και αντιφατικός. Παράλληλα, τα μέσα επικοινωνίας καταλαμβάνουν κυρίαρχη θέση σε αυτό τον κόσμο και συνήθως υπερισχύουν άλλων τομέων της κοινωνίας, αλλά και της οικονομίας. Συχνά, οι περισσότεροι κοινωνικοί θεσμοί, αν όχι όλοι, εξαναγκάζονται να προσαρμοστούν στις απαιτήσεις της σύγχρονης «διαμεσολαβημένης» κοινωνίας. Στόχος του βιβλίου είναι να αναδειχθούν σύγχρονα ζητήματα που απασχολούν το σύγχρονο και πολυσύνθετο πεδίο της επικοινωνίας. Οι συγγραφείς του βιβλίου θίγουν ζητήματα που απασχολούν τους μελετητές όσον αφορά στη σχέση των μέσων επικοινωνίας και της κοινωνίας στον 21ο αιώνα, και αναλύουν τις αλλαγές που έχουν συντελεστεί στο πεδίο της επικοινωνίας, στο επίπεδο της θεωρίας, της δομής και, πιο συγκεκριμένα, στους χώρους της ενημέρωσης, της πολιτικής, της δημοσιογραφίας και των σχέσεων των πολιτών με τα νέα μέσα επικοινωνίας.

Purpose – The purpose of this paper is to explore the concept of health-related needs on a policy design and curriculum enactment basis in terms of the national school health education curriculum in Greek secondary education. Design/methodology/approach – A single case study, using an ethnographic approach, was conducted in Greece, seeking to understand the continuum from policy design to curriculum enactment in respect of health-related needs. Three sources of data were used to meet this goal: policy texts, observation, and interviews. Multilevel sampling was employed to select one secondary school as a site for “good practice”. Grounded theory coding, thematic analysis and critical discourse analysis identified themes associated with the idea of health-related through the corpus of data. Findings – On a policy plan level the concept of health-related needs was coupled with and reduced to a predetermined list of health-related subjects; and the list of health-related topics had not been updated for long and was characterised by a rather biomedical orientation. On a school practice level the stage of needs assessment was not applied, the list of health-related subjects advocated in the policy plan was used on a proactive, normative and top down basis, and the students' felt needs tended to be disregarded. Originality/value – This study followed up the continuum from policy design to school practice regarding the concept and practice of health needs, highlighting the possibilities and the problems from both perspectives.

BACKGROUND: FAD dependent glucose dehydrogenase (GDH) currently raises enormous interest in the field of glucose biosensors. Due to its superior properties such as high turnover rate, substrate specificity and oxygen independence, GDH makes its way into glucose biosensing. The recently discovered GDH from the ascomycete Glomerella cingulata is a novel candidate for such an electrochemical application, but also of interest to study the plant-pathogen interaction of a family of wide-spread, crop destroying fungi. Heterologous expression is a necessity to facilitate the production of GDH for biotechnological applications and to study its physiological role in the outbreak of anthracnose caused by Glomerella (anamorph Colletotrichum) spp. RESULTS: Heterologous expression of active G. cingulata GDH has been achieved in both Escherichia coli and Pichia pastoris, however, the expressed volumetric activity was about 4800-fold higher in P. pastoris. Expression in E. coli resulted mainly in the formation of inclusion bodies and only after co-expression with molecular chaperones enzymatic activity was detected. The fed-batch cultivation of a P. pastoris transformant resulted in an expression of 48,000 U L(-)(1) of GDH activity (57 mg L(-)(1)). Recombinant GDH was purified by a two-step purification procedure with a yield of 71%. Comparative characterization of molecular and catalytic properties shows identical features for the GDH expressed in P. pastoris and the wild-type enzyme from its natural fungal source. CONCLUSIONS: The heterologous expression of active GDH was greatly favoured in the eukaryotic host. The efficient expression in P. pastoris facilitates the production of genetically engineered GDH variants for electrochemical-, physiological- and structural studies.

The histidine-rich calcium binding protein (HRC) is a novel regulator of sarcoplasmic reticulum (SR) Ca(2+)-uptake, storage and release. Residing in the SR lumen, HRC binds Ca(2+) with high capacity but low affinity. In vitro phosphorylation of HRC affects ryanodine affinity of the ryanodine receptor (RyR), suggesting a functional role of HRC on SR Ca(2+)-release. Indeed, acute HRC overexpression in isolated rodent cardiomyocytes decreases Ca(2+)-induced Ca(2+)-release, increases SR Ca(2+)-load, and impairs contractility. The HRC effects on RyR may be regulated by the Ca(2+)-sensitivity of its interaction with triadin. However, HRC also affects the SR Ca(2+)-ATPase, as shown by HRC overexpression in transgenic mouse hearts, which resulted in reduced SR Ca(2+)-uptake rates, cardiac remodeling and hypertrophy. In fact, in vitro generated evidence suggests that HRC directly interacts with SR Ca(2+)-ATPase2, supporting a dual role of HRC in Ca(2+)-homeostasis: regulation of both SR Ca(2+)-uptake and Ca(2+)-release. Furthermore, HRC plays an important role in myocyte differentiation and in antiapoptotic cardioprotection against ischemia/reperfusion induced cardiac injury. Interestingly, HRC has been linked with familiar cardiac conduction disease and an HRC polymorphism was shown to associate with malignant ventricular arrhythmias in the background of idiopathic dilated cardiomyopathy. This review summarizes studies, which have established the critical role of HRC in Ca(2+)-homeostasis, suggesting its importance in cardiac physiology and pathophysiology.

Ce travail se penche sur un aspect de la coopération franco-hellénique dans le domaine de la formation au professorat de français. Elle porte plus précisément sur la période 1954-1991 et étudie la mise sur pied à l’université d’Athènes d’une structure de préparation professionnelle destinée aux francisants. La France participe à cette entreprise avec une équipe enseignante composée de docteurs d’État, d’agrégés et de licenciés. L’étude examine le cadre de cohabitation, au sein de la Section française d’abord, du Département de langue et littérature françaises plus tard, de deux personnels, français et grec, qui tout en ayant un but commun, devaient, en même temps, servir les politiques culturelles/éducatives de leur pays respectif. Elle constitue un premier bilan des résultats d’une recherche en cours.Dans la première partie qui couvre la période 1954-1976, est évoqué, en premier lieu, le contexte géopolitique en pleine reconstruction qui émerge après la Seconde Guerre mondiale et qui conduit à une redistribution des zones d’influence entre les grandes puissances occidentales dans le domaine linguistique et culturel. Ces mutations entraînent, d’une part, la perte des privilèges français dans ce domaine et, d’autre part, une reformulation des stratégies universitaires concernant la formation des professeurs de langues étrangères ; celles-ci se concrétisent par la création de sections universitaires de préparation à cette spécialité. Suit l’examen des textes législatifs constitutifs de la Section française qui révèle les choix stratégiques qui ont prévalu et la philosophie qui a présidé lors de leur élaboration : former des fonctionnaires hellènes imbus d’une culture gréco-française ; placer cette structure sous la haute surveillance des autorités universitaires. L’analyse s’intéresse plus particulièrement au partenariat entre les deux équipes, française et grecque, inauguré par la loi de 1954. Cette collaboration n’était pas conçue sur un pied d’égalité : la loi réservait un rôle subordonné à la partie française. Il n’empêche que la responsabilité administrative de la Section (gestion économique et coordination des auxiliaires d’enseignement) était assumée par l’un des deux titulaires français des chaires créées. Une première approche du profil de l’équipe française, groupe de fonctionnaires migrants, est tentée dans un deuxième temps : composition sexuée, titres, durée des missions, difficultés de recrutement. Cette première partie se termine par une brève étude du groupe quasi-féminin de maîtres-assistant.e.s grec.que.s constitué à partir de 1964 pour faire face à l’augmentation vertigineuse de la population étudiante. La deuxième partie du travail qui examine la période 1976-1991 met en relief le processus de désengagement de la partie française de la direction de la Section. Cette rupture est le résultat de la réorientation des politiques culturelles françaises dans le domaine de l’enseignement à l’étranger. De leur côté, les professeurs grecs mettent en place les structures adéquates qui permettront l’affranchissement des sections universitaires de langues vivantes de la tutelle étrangère : création de chaires, recrutement d’un personnel grec plus nombreux et mieux instruit. Ces stratégies conduisent inévitablement à l’hellénisation et à la féminisation des structures de formation en question. En 1991, prend fin la mission du dernier lecteur français à la Section française athénienne et avec elle la collaboration franco-hellénique dans ce domaine.

The historical variation of scientific knowledge has lent itself to the development of historical epistemology, which attempts to historicize the origin and establishment of knowledge claims. The questions I address in this paper revolve around the historicity of the objects of those claims: How and why do new scientific objects appear? What exactly comes into being in such cases? Do scientific objects evolve over time and in what ways? I put forward and defend two theses: First, the ontology of science is so rich and variegated that there are no universally valid answers to these questions. Second, we need a pluralist account of scientific objects, a pluralist metaphysics that can do justice to their rich diversity and their various modes of being and becoming. I then focus on hidden objects, which are supposed to be part of the permanent furniture of the universe, and I discuss their birth and historicity: They emerge when various phenomena coalesce as manifestations of a single hidden cause and their representations change over time. Finally, I examine the conditions under which an evolving representation may still refer to the same object and I illustrate my argument drawing upon the early history of electrons.

The Eastern Mediterranean Sea lies in a climatological transition zone, under the influence of both tropical and mid-latitude climate processes. Within this basin, the Aegean Sea has been recognized as a highly sensitive area to global/regional climate change. Sediment archives provide robust evidence for changes in its hydrological properties and biogeochemical functioning as a response to past climate variability. In order to investigate the region's paleoclimatic and paleoceanographic patterns during the Holocene, with a special emphasis on the sapropel S1 interval, we have investigated marine sediment cores along a N-S transect in the Aegean and the S. Cretan Seas. We focus on combined geochemical, micropaleontological and palynological proxies, namely organic biomarkers, organic carbon and nitrogen stable isotopes, coccolithophore and pollen assemblages, aiming at reconstructing climate-related parameters such as sea surface temperature (SST), marine productivity patterns, stratification and nutricline fluctuations, continental vegetation patterns and land-sea interactions. SST patterns depict major global/regional climate fluctuations during the last glacial and deglaciation periods, depict the warm transition to the Holocene optimum, when the formation of the S1 sapropel takes place, a distinct cool episode around 8 ka BP (coeval with the S1 interruption), a conspicuous mid-Holocene warm phase (5.4-4.3 ka BP) as well as other distinct fluctuations. Diagnostic marine lipids, δ15N, and coccolithophore assemblages allow documenting the variability of primary productivity and associated organic carbon accumulation in sediments, as well as fluctuations in water column stratification and nutricline, especially during the deposition of the S1 sapropel. Combined terrigenous proxies record warm/cool and dry/humid time intervals, allowing land-sea correlations, and document changes in the delivery of terrestrial material to the sea related to climate-driven fluctuations in freshwater discharges. The network of sediment cores studied provide a better constrain of the regional climate patterns in the northeastern Mediterranean Sea and enables assessing potential time lags and gradients.

Detailed mapping of coastline around Theologos area revealed the existence of well developed permanently submerged notches 75 ± 10 cm below present mean sea level. The regional occurrence of well preserved submerged tidal notches suggests their coseismic origin. The submergence of this Holocene shoreline possibly occurred at 1894 AD. Average submergence rate of 6.08 mm/yr may be estimated by a well preserved recumbent U-shaped notch. The retreating point depth suggests that the developing period of the notch might have been of the order of as much as three thousand years. Several non in situ large rock blocks, containing marine fossils (Lithophaga, Vermetids, Serpulids) in growth position, seem to have been projected on the coast by a tsunami wave, which might have been caused by the same coseismic episode.

In an effort to increase ethanol productivity during the consolidated bioprocessing (CBP) of lignocellulosics by Fusarium oxysporum, we attempted the constitutive homologous overexpression of one of the key process enzymes, namely an endo-xylanase. The endo-β-1,4-xylanase 2 gene was incorporated into the F. oxysporum genome under the regulation of the gpdA promoter of Aspergillus nidulans. The transformation was effected through Agrobacterium tumefaciens and resulted in 12 transformants, two of which were selected for further study due to their high extracellular xylanase activities under normally repressing conditions (glucose as sole carbon source). During natural induction conditions (growth on xylan) though, the extracellular enzyme levels of the transformants were only marginally higher (5–10%) compared to the wild type despite the significantly stronger xylanase 2 mRNA signals. SDS-PAGE verified enzyme assay results that there was no intracellular xylanase 2 accumulation in the transformants, suggesting the potential regulation in a post transcriptional or translational level. The fermentative performance of the transformants was evaluated and compared to that of the wild type in simple CBP systems using either corn cob or wheat bran as sole carbon sources. Both transformants produced approximately 60% more ethanol compared to the wild type on corn cob, while for wheat bran this picture was repeated for only one of them. This result is attributed to the high extracellular xylanase activities in the transformants’ fermentation broths that were maintained 2–2.5-fold higher compared to the wild type.

This paper describes an empirical study aiming to assess nursing students' perceptions on Electronic Health Record (EHR) concepts and their potential future attitude towards use. Based on the theoretical ground of Rogers' Innovation Diffusion Theory and other research works, a formulated model was empirically validated among ninety nursing undergraduates. Data analysis was based on partial least squares path modeling. Results highlighted the very strong significant effect of relative advantage and observability as well as the significant effect of perceived ease of use to attitude towards using EHR systems. The study findings are discussed along with limitations and future work in the current field. © 2011 European Federation for Medical Informatics. All rights reserved.

This paper describes an empirical study aiming to assess nursing students' perceptions on Electronic Health Record (EHR) concepts and their potential future attitude towards use. Based on the theoretical ground of Rogers' Innovation Diffusion Theory and other research works, a formulated model was empirically validated among ninety nursing undergraduates. Data analysis was based on partial least squares path modeling. Results highlighted the very strong significant effect of relative advantage and observability as well as the significant effect of perceived ease of use to attitude towards using EHR systems. The study findings are discussed along with limitations and future work in the current field.

Specific immunotherapy (SIT) is one of the treatments for allergic rhinitis. However, for allergists, nonspecialists, regulators, payers, and patients, there remain gaps in understanding the evaluation of randomized controlled trials (RCTs). Although treating the same diseases, RCTs in SIT and pharmacotherapy should be considered separately for several reasons, as developed in this study. These include the severity and persistence of allergic rhinitis in the patients enrolled in the study, the problem of the placebo, allergen exposure (in particular pollen and mite), the analysis and reporting of the study, the level of symptoms of placebo-treated patients, the clinical relevance of the efficacy of SIT, the need for a validated combined symptom-medication score, the differences between children and adults and pharmacoeconomic analyses. This statement reviews issues raised by the interpretation of RCTs in sublingual immunotherapy. It is not possible to directly extrapolate the rules or parameters used in medication RCTs to SIT. It also provides some suggestions for the research that will be needed. Interestingly, some of the research questions can be approached with the available data obtained from large RCTs.

We perform aperture photometry and profile fitting on 419 globular cluster (GC) candidates with mV <= 23 mag identified in Hubble Space Telescope/Advanced Camera for Surveys BVI imaging, and estimate the effective radii of the clusters. We identify 85 previously known spectroscopically confirmed clusters, and newly identify 136 objects as good cluster candidates within the 3σ color and size ranges defined by the spectroscopically confirmed clusters, yielding a total of 221 probable GCs. The luminosity function peak for the 221 probable GCs with estimated total dereddening applied is V ~ (20.26 ± 0.13) mag, corresponding to a distance of ~3.7 ± 0.3 Mpc. The blue and red GC candidates, and the metal-rich and metal-poor spectroscopically confirmed clusters, respectively, are similar in half-light radius. Red confirmed clusters are about 6% larger in median half-light radius than blue confirmed clusters, and red and blue good GC candidates are nearly identical in half-light radius. The total population of confirmed and "good" candidates shows an increase in half-light radius as a function of galactocentric distance. Based on observations with the Hubble Space Telescope obtained at the Space Telescope Science Institute, operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-26555. These observations are associated with Program GO-10250 and Program GO-10584.

Human Papilloma Virus (HPV) is becoming a menace worldwide, especially to the developing world, due to its involvement in a variety of malignancies, with cervical cancer being the most important and prevalent. There are many HPV types; HPV 16/18 are the most carcinogenic but few others are also characterized as high-risk (HR). They can cause a variety of low- or high-grade cellular abnormalities, most frequently detected in a routine Pap test. Most infections clear within 2 years, however, a minority persists and potentially could progress to cervical cancer. Molecular tests detecting HPV DNA, RNA or proteins are now being available either commercially or in-house developed. DNA detection is nowadays an established tool for diagnosis and monitoring of HPV-related disease, however, there is lack of a reference method and standardization with reference materials. The various available test formats create confusion on which molecular test to choose and what are its limitations. Therefore, the need for lab accreditation and participation in proficiency testing has to be stressed. Novel HPV biomarkers (RNA, protein etc.) are now intensively examined for their inclusion as adjunct tools. Recently, developed prophylactic vaccines for HPV 16/18 have already proven safe and efficient and raise high expectations for the complete eradication of these types in the future

The goal of this study is the analysis of heat waves and their impact on humans, using human biometeorological indices, which are based on the energy balance of the human body. The implications for humans are not only described through the intensity of the heat waves, but also through their duration over consecutive days. Both intensity and duration were analyzed for the Greater Athens Area during the period 1955 to 2001. The analysis was carried out using the daily physiologically equivalent temperature and the daily minimum air temperature. Based on these two parameters, the results showed an increase in the average duration of heat waves. Furthermore, the use of the Gaussian filter revealed the intra-annual variation of heat stress conditions and their relevance to humans. The results could be used for the management of the negative consequences of heat waves in cities suffering from environmental pollution and also for climate impact studies. © 2010 Springer-Verlag.

Context: Ovarian and adrenal hyperandrogenism characterize premenopausal women with polycystic ovary syndrome (PCOS). Androgens decline with age in healthy and PCOS women. Objective: The objective of the study was to investigate hyperandrogenism in PCOS after menopause. Design: This was a case-control, cross-sectional study. Setting: The study was conducted at a university hospital endocrinology unit. Patients: Twenty postmenopausal women with PCOS and 20 age- and body mass index-matched controls participated in the study. Interventions: Serum cortisol, 17-hydroxyprogesterone (17-OHP), Δ4- androstenedione (Δ4A), dehydroepiandrosterone sulfate (DHEAS), total testosterone (T), and free androgen index (FAI) levels were measured at baseline, after ACTH stimulation, and after 3-d dexamethasone suppression. The ACTH and cortisol levels were measured during the CRH test. Main Outcome Measures: Androgen profile at baseline, after ACTH stimulation, and 3-d dexamethasone suppression tests were the main outcome measures. Results: Postmenopausal PCOS women had higher 17-OHP, Δ4A, DHEAS, total T, FAI (P < 0.05) and lower SHBG (P<0.05) baseline levels than control women. ACTH and cortisol responses during the CRH test were similar in the two groups. After ACTH stimulation, Δ4A, DHEAS, and total T levels were equally increased in both groups. After dexamethasone suppression, LH levels did not change in either group; 17-OHP-, Δ4A-, and FAI-suppressed levels remained higher in PCOS than in control women (P < 0.05), whereas total T and DHEAS levels were suppressed to similar values in both groups. Conclusions: In postmenopausal PCOS women, ACTH and cortisol responses to CRH are normal. Androgen levels at baseline are higher in PCOS than control women and remain increased after ACTH stimulation. The dexamethasone suppression results in postmenopausal PCOS women suggest that DHEAS and total T are partially of adrenal origin. Although the ovarian contribution was not fully assessed, increased Δ4A production suggests that the ovary also contributes to hyperandrogenism in postmenopausal PCOS women. In conclusion, postmenopausal PCOS women are exposed to higher adrenal and ovarian androgen levels than non-PCOS women. Copyright © 2011 by The Endocrine Society.

We recently described paratarg-7 (P-7), a protein of unknown function, as the target of 15% of immunoglobulin A (IgA) and IgG paraproteins in monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma. To determine the frequency of P-7 as a paraprotein target in IgM-MGUS and Waldenström macroglobulinemia (WM), sera from patients with IgM-MGUS/WM were tested for reactivity with recombinant P-7 by enzyme-linked immunoabsorbent assay. The specificity of the paraprotein-mediated reaction was shown by absorption studies and cloning of the respective B-cell receptor. The paraproteins of 18 (9 WM and 9 IgM-MGUS) of 161 patients (11%) reacted with P-7. Isoelectric focusing and phosphatase treatment showed that P-7 was hyperphosphorylated (pP-7) in all patients with an anti - P-7-specific IgM paraprotein tested. Because only 4 of 200 healthy controls (2%) were carriers of pP-7, pP-7 carrier state is associated with a significantly increased risk (odds ratio = 6.2; P = .001) for developing IgM-MGUS/MW. Family analyses showed that the pP-7 carrier state is inherited as a dominant trait. After IgA/IgGMGUS and multiple myeloma, IgMMGUS/WM is the second neoplasia associated with pP-7 carrier state. The dominant inheritance of pP-7 explains cases of familial IgM-MGUS/WM and enables the identification of family members at increased risk. © 2011 by The American Society of Hematology.

Development and homeostasis of multicellular organisms relies on an intricate balance between cell proliferation and differentiation. Geminin regulates the cell cycle by directly binding and inhibiting the DNA replication licensing factor Cdt1. Geminin also interacts with transcriptional regulators of differentiation and chromatin remodelling factors, and its balanced interactions are implicated in proliferation-differentiation decisions during development. Here, we describe Idas (Idas being a cousin of the Gemini in Ancient Greek Mythology), a previously uncharacterised coiled-coil protein related to Geminin. We show that human Idas localizes to the nucleus, forms a complex with Geminin both in cells and in vitro through coiled-coil mediated interactions, and can change Geminin subcellular localization. Idas does not associate with Cdt1 and prevents Geminin from binding to Cdt1 in vitro. Idas depletion from cells affects cell cycle progression; cells accumulate in S phase and are unable to efficiently progress to mitosis. Idas protein levels decrease in anaphase, whereas its overexpression causes mitotic defects. During development, we show that Idas exhibits high level expression in the choroid plexus and the cortical hem of the mouse telencephalon. Our data highlight Idas as a novel Geminin binding partner, implicated in cell cycle progression, and a putative regulator of proliferation-differentiation decisions during development.

Aims: IKT 16 is an X-ray and radio-faint supernova remnant (SNR) in the Small Magellanic Cloud (SMC). A previous X-ray study of this SNR found a hard X-ray source near its centre. Using all available archival and proprietary XMM-Newton data, alongside new multi-frequency radio-continuum surveys and optical observations at Hα and forbidden [SII] and [OIII] lines, we aim to constrain the properties of the SNR and discover the nature of the hard source within. Methods: We combine XMM-Newton datasets to produce the highest quality X-ray image of IKT 16 to date. We use this, in combination with radio and optical images, to conduct a multi-wavelength morphological analysis of the remnant. We extract separate spectra from the SNR and the bright source near its centre, and conduct spectral fitting of both regions. Results: We find IKT 16 to have a radius of 37 ± 3 pc, with the bright source located 8 ± 2 pc from the centre. This is the largest known SNR in the SMC. The large size of the remnant suggests it is likely in the Sedov-adiabatic phase of evolution. Using a Sedov model to fit the SNR spectrum, we find an electron temperature kT of 1.03 ± 0.12 keV and an age of ≈14700 yr. The absorption found requires the remnant to be located deep within the SMC. The bright source is fit with a power law with index Γ = 1.58 ± 0.07, and is associated with diffuse radio emission extending towards the centre of the SNR. We argue that this source is likely to be the neutron star remnant of the supernova explosion, and infer its transverse kick velocity to be 580 ± 100 km s-1. The X-ray and radio properties of this source strongly favour a pulsar wind nebula (PWN) origin. Based on observations obtained with XMM-Newton, an ESA science mission with instruments and contributions directly funded by ESA Member States and NASA.

We have undertaken a meta-analysis of the English literature, to assess the component alignment outcomes after imageless computer assisted (CAOS) total knee arthroplasty (TKA) versus conventional TKA. We reviewed 23 publications that met the inclusion criteria. Results were summarised via a Bayesian hierarchical random effects meta-analysis model. Separate analyses were conducted for prospective randomised trials alone, as well as for all randomised and observational studies. In 20 papers (4,199 TKAs) we found a reduction in outliers rate of approximately 80% in limb mechanical axis when operated with the CAOS. For the coronal femoral and tibial implants positions, the analysis included 3,058 TKAs. The analysis for the femoral implant showed a reduction in outliers rate of approximately 87% and for the tibial implant a reduction in outliers rate of approximately 80%. Imageless navigation when performing TKA improves component orientation and postoperative limb alignment. The clinical significance of these findings though has to be proven in the future.

Dans cet article, nous présentons la revue Le Tour du monde : journal des voyages, qui a été publiée par Édouard Charton, et nous nous attardons sur l’importance de son illustration. Plus précisément nous traitons de la représentation de l’Autre dans les récits des voyages, qui étaient publiés entre 1860 et le début du XXe sièle. Constituant un corpus hétérogène, les articles rédigés par des auteurs comme Henri Cammas, Ernest Chantre, Bellonie Chantre, Louis Lortet, Charles Grad et Paul Merruaut et illustrés par des artistes célèbres comme Édouard Riou, Henriette Browne et Adalabert de Beaumont, communiquent des informations importantes sur les populations des endroits parcourus. Quoique les auteurs de la TdM, qui avaient des relations superficielles avec les populations des contrées parcourues, n’aient pas évité une représentation stéréotypée de l’Autre, leurs descriptions et leurs commentaires sur l’apparence extérieure ainsi que leurs références à la religion, au dogme, aux moeurs et aux coutumes des habitants ont reconstitué une image vivante et variée de l’Orient. Notre étude s’attarde également sur l’illustration des articles, qui, appuyée sur un matiériel iconographique varié (dessins, photographies), fournit des informations précieuses sur les sujets traités.

Lapsley’s (1993) “New Look” model for the interpretation of adolescent egocentrism, as an alternative to the classic cognitive one formulated by Elkind (1967), was tested in this study. According to the “New Look” model, the two manifestations of adolescent egocentrism – the imaginary audience and the personal fable – are adaptive coping mechanisms used by adolescents in their attempt to deal with the stressful developmental aim of separation-individuation. Two-hundred ninety seven adolescents 11-18 years’ old completed the Imaginary Audience Scale (Elkind & Bowen, 1979), the New Imaginary Audience Scale (Lapsley, Fitzgerald, Rice, & Jackson, 1989), the Personal Fable Scale (Elkind, personal communication, August 10, 1993), the New Personal Fable Scale (Lapsley et al., 1989), and the Separation-Individuation Test of Adolescence (Levine, Green, & Millon, 1986; Levine & Saintonge, 1993). The “New Look” model was generally supported by the data. The various dimensions of separation were significantly associated with the imaginary audience, whereas the dimensions of individuation had stronger links with the personal fable. In addition, some associations were found between the imaginary audience and individuation, as well as between the personal fable and separation. Consistent age and gender differences in the variables studied were found. Results are discussed in the framework of the literature on adolescent egocentrism and on parent-adolescent relations.

A prospective epidemiologic surveillance of hospitalizations associated with influenza was conducted in order to calculate population-based hospitalization rates. Eligible children were 6 months to 13 years of age and were admitted to one of the two large children's hospitals in the Athens area during two influenza seasons. Nasopharyngeal aspirates were tested for influenza by a polymerase reaction assay. Influenza accounted for 9.9-11.8% of all admissions during the influenza season and the overall annual rate of hospitalizations was 13.6-16.8 cases per 10,000 children being highest for children under 5 years of age (26-31.2/10,000 children). Febrile seizures and acute otitis media were the two most common complications associated with influenza and antibiotics were administered to 61% of flu positive patients. Influenza is associated with high hospitalization rates among young children and these may be substantially reduced with the introduction of routine immunization.

This analysis assessed the effect of lenalidomide on progression-free survival (PFS). Patients with relapsed or refractory multiple myeloma (RRMM) who received lenalidomide plus dexamethasone in the MM-009 and MM-010 trials were pooled and those who had not progressed and were still receiving lenalidomide at 12 months were included. The median follow-up of surviving patients was 48 months. Of 353 patients who received lenalidomide plus dexamethasone, 116 (33%) had not progressed. Overall, 52 patients (45%) had no dose reductions, 25 (22%) had dose reductions ≥12 months and 39 (34%) had dose reductions before 12 months. Patients who had dose reductions ≥12 months had a significantly longer median PFS than those who had reductions before 12 months (P=0.007) or no dose reductions (P=0.039) (not reached vs 28.0 vs 36.8 months, respectively). In a multivariate Cox regression model, dose reduction ≥12 months was an independent predictor of improved PFS (hazard ratio, 0.47; 95% confidence interval, 0.23-0.98) after adjusting for patient characteristics. The data suggest that to achieve maximum PFS benefit, patients with RRMM should be treated for ≥12 months with full-dose lenalidomide plus dexamethasone. Thereafter, patients may benefit from lower-dose continued therapy; prospective studies are needed to confirm these findings. © 2011 Macmillan Publishers Limited All rights reserved.

BACKGROUND: The heptavalent pneumococcal conjugate vaccine (PCV7) has a considerable effect on the epidemiology of pneumococcal disease. The aim of this observational hospital-based study was to examine the effect of the PCV7 (introduced in our settings in 2004) on the epidemiology of spontaneously draining acute otitis media. METHODS: Results of all middle ear fluid cultures (n = 3446) obtained from children with acute otitis media complicated with otorrhea before the introduction of immunization (between 2000 and 2003) were compared with those (n = 2134) obtained during a similar post-PCV7 period (between 2005 and 2008). Results of cultures obtained between 2006 and 2008 were examined prospectively, whereas those obtained in previous years were retrospectively reviewed. RESULTS: Following PCV7 immunization, the rates of otorrhea visits per 10,000 emergency department visits decreased by 38% from 133 to 83 (95% confidence interval of the difference, 42-53; P < 0.001), mainly as a result of the decrease in the incidence of pneumococcal disease (48% decrease-25 vs. 13 per 10,000 emergency department visits; P < 0.001). Otorrhea due to Haemophilus influenzae decreased by 20% (20-16 per 10,000 visits; P < 0.001). Serotype 19A accounted for 1 of 47 (2%) pneumococcal strains in 2006, for 5 of 34 (15%) in 2007, and for 13 of 53 (25%) in 2008 (P for trend: 0.001). In the postvaccine years, penicillin-resistant pneumococcal strains (minimum inhibitory concentration >/= 2 mug/mL) increased from 4% to 13% (P < 0.001). However, the proportion of pneumococci resistant to macrolides decreased (44% vs. 35%; P = 0.01). CONCLUSIONS: After the introduction of immunization, otorrhea incidents decreased considerably, mainly because of the decrease in pneumococcal disease. H. influenzae is now the predominant organism. Serotype 19A has increased significantly and is the most common nonvaccine pneumococcal serotype. Penicillin resistance has increased in recent years.

Aims: We investigate photon quenching in compact non-thermal sources. This involves photon-photon annihilation and lepton synchrotron radiation in a network that can become non-linear. As a result the γ-ray luminosity of a source cannot exceed a critical limit that depends only on the radius of the source and on the magnetic field. Methods: We perform analytic and numerical calculations that verify previous results and extend them so that the basic properties of photon quenching are investigated. Results: We apply the above to the 2006 TeV observations of quasar 3C 279 and obtain the parameter space of allowed values for the radius of the emitting source, its magnetic field strength and the Doppler factor of the flow. We argue that the TeV observations favour either a modest Doppler factor and a low magnetic field or a high Doppler factor and a high magnetic field.

Aims: We investigate photon quenching in compact non-thermal sources. This involves photon-photon annihilation and lepton synchrotron radiation in a network that can become non-linear. As a result the γ-ray luminosity of a source cannot exceed a critical limit that depends only on the radius of the source and on the magnetic field. Methods: We perform analytic and numerical calculations that verify previous results and extend them so that the basic properties of photon quenching are investigated. Results: We apply the above to the 2006 TeV observations of quasar 3C 279 and obtain the parameter space of allowed values for the radius of the emitting source, its magnetic field strength and the Doppler factor of the flow. We argue that the TeV observations favour either a modest Doppler factor and a low magnetic field or a high Doppler factor and a high magnetic field.

The coexistence of cerebral infarcts and Alzheimer's disease (AD) is common, but the influence of symptomatic cerebral infarcts on cognition is uncertain in AD. We hypothesize that symptomatic cerebral infarcts may provide an additive cognitive factor contributing to dementia in the AD population. We studied 1,001 clinically probable or possible AD patients in the Alzheimer Disease Research Center (ADRC) database. Linear regression was used to evaluate for an association between symptomatic cerebral infarcts and memory, language, executive function, abstract reasoning, and visuospatial performance, separately. Models were adjusted for covariates including age, gender, education, ethnicity, hypertension, diabetes mellitus, heart disease, clinical dementia rating, the presence of silent cerebral infarcts, and multiplicity or location of infarcts. Clinical history of stroke was present in 107 patients, radiological infarcts in 308 patients, and 68 patients with both were considered to have symptomatic infarcts. Adjusting for all covariates, AD patients with symptomatic infarcts had more impairment of executive function (P < 0.05). The influence of cerebral infarcts is neither general nor diffuse, and the presence of clinical history may have a more important influence on executive performance in AD.

The complexes [Ru(Tai)H(PPh3)2] (4) [Tai = HB(7-azaindolyl)3] and [Ru(ArBai)H(PPh3) 2] [ArBai = Ar(H)B(7-azaindolyl)2; Ar = phenyl (5), mesityl (6) and 2-naphthyl (7)] have been prepared and fully characterised. Structural characterisation of complexes 4, 5 and 7 confirmed the expected κ3-NNH coordination mode of the azaindolyl-based ligands. In all complexes, the borohydride unit is located trans to the hydrido ligand, and the two triphenylphosphane ligands occupy sites trans to the two nitrogen donors. The strong Ru⋯H-B interaction means that the third substituent at the boron atom is held in close proximity to the ruthenium centre. In the case of complex 7, rotation of the naphthyl group about the boron centre is hindered by the triphenylphosphane substituents. The synthesis of a number of ruthenium hydride complexes containing azaindole-based scorpionate ligands is reportedherein. The scorpionate ligands bind to the metal centre with κ3-NNH coordination modes. The strong borohydride⋯metal interaction pulls the additional substituent at the boron atom towards the bulky triphenylphosphane ligands. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Osteoarthritis (OA) is a slowly progressive degenerative joint disease that is associated with joint space narrowing, osteophyte formation and subchondral sclerosis. Despite extensive effort actual breakthroughs in the field of genetic or biochemical biomarkers of OA are limited. As secretory apolipoprotein J/clusterin (sCLU) has been implicated in both inflammatory and apoptotic molecular processes which contribute to the OA phenotype, the sCLU concentration in human serum and synovial fluid during advanced primary knee and hip OA was analysed. Elevated sCLU protein levels were shown in these two biological fluids. sCLU mRNA expression was also studied in normal cartilage and in advanced primary knee and hip OA samples. A significant up-regulation of sCLU mRNA expression (∼25-fold) was found in samples collected from the tibial bone that was osteotomized during total knee arthroplasty in patients with primary knee OA, as compared to healthy tissue samples collected from the femoral head of macroscopically normal cartilage during the surgical treatment of subcapital fractures. By studying sCLU mRNA expression levels in samples collected during total hip arthroplasty in patients with advanced primary hip OA, an additional up-regulation of the sCLU mRNA expression (∼4-fold), as compared to advanced primary knee OA, was found. Taken together, these observations indicate that the sCLU protein or mRNA expression level may be of a significant diagnostic and/or prognostic value during OA progression.

Dilated cardiomyopathy (DCM) is associated with increased inflammatory response reflected among other markers in high-sensitivity C-reactive protein (hsCRP) and soluble interleukin-2 receptor (sIL-2R) levels. We examined prospectively 60 consecutive patients with DCM. Of them, 30 were dyslipidemic (group I) and 30 normolipidemic (group II). Group I patients were randomized to either simvastatin therapy (20 mg/day, group Ia, n = 15) or hypolipidemic diet therapy (group Ib, n = 15). Patients were re-evaluated 6 months later. High-sensitivity C-reactive protein and sIL-2R levels were significantly higher in group I compared with group II patients (19.5 +/- 3.4 vs 3.03 +/- 3.5 mg/L, P = .01, 1137 +/- 441 vs 599 +/- 235 pg/mL, P = .001, respectively). There was a significant correlation between sIL-2R and hsCRP levels in dyslipidemic patients but not in normolipidemic patients. Significant reduction of hsCRP and sIL-2R levels was observed only in group Ia patients. Patients with DCM having dyslipidemia have increased inflammatory response, which is reduced after 6 months of statin therapy

In 203 consecutive unselected patients with symptomatic MM who received upfront treatment with novel agents, high levels of serum LDH were independently associated with poor survival and could identify subgroups of patients within ISS-2 and ISS-3 with even worse outcome. Evaluating serum LDH levels is a simple, inexpensive, and readily available procedure that could be considered among the variables that define very-high-risk MM. Background: In patients who have symptomatic multiple myeloma (MM), a high serum lactate dehydrogenase (LDH) level is associated with features of advanced disease, adds prognostic value to the international staging system (ISS) and predicts for inferior survival. However, it has not been clearly defined what the impact of this abnormality is for patients treated upfront with novel agent-based regimens. Patients and Methods: To address this issue we analyzed 203 consecutive unselected patients with symptomatic MM who received upfront treatment with novel agents in a single center. Results: The median overall survival for patients with normal LDH was 54 months but in patients with increased LDH levels it was 21 months (P =.003), whereas increased serum LDH was associated with a higher probability of early death. Multivariate analysis confirmed that an increased LDH level is independently associated with poor survival. Furthermore, increased LDH levels could identify subgroups of patients within ISS-2 and ISS-3 with even worse outcome. Conclusion: We conclude that serum LDH is a simple, inexpensive, and readily available blood test that may be included among the variables that define very-high-risk MM. © 2011 Elsevier Inc. All rights reserved.

OBJECTIVES: The study aimed to evaluate a wide range of apoptotic markers in the vein wall of patients with superficial chronic venous disease (SCVD) compared with normal veins. DESIGN: This was an observational study. METHODS: Vein specimens were obtained from 19 patients suffering from SCVD. From each patient, a specimen of the proximal part of the great saphenous vein (GSV), a specimen of the distal part of the vein and a specimen of a varicose tributary were obtained. Immunohistochemical analysis was used to localise the expression of BAX, p53, Caspase 3, BCL-2, BCL-6, BCL-xs, BCL-xl and Ki-67. Vein specimens from 10 healthy GSVs were used as controls. RESULTS: Saphenous vein specimens from patients with SCVD showed increased BAX, Caspase 3, BCL-xl and BCL-xs (p < 0.01 for all) and Ki-67 (p = 0.02) compared with healthy GSVs. In the venous disease group, GSV specimens from the distal ankle area showed increased BAX (p < 0.01) and BCL-xs (p = 0.031) compared with varicose tributaries specimens, which subsequently showed increased BAX (p = 0.044), Caspase 3 (p = 0.028) and BCL-xs (p = 0.037) compared with specimens from the proximal GSV. In addition, in the venous disease group, specimens from distal GSV showed increased BAX (p < 0.01), Caspase 3 (p = 0.019) and BCL-xs (p = 0.014) compared with the proximal GSV. CONCLUSION: Varicose veins exhibit increased apoptotic activity, by means of increased BAX, Caspase 3, BCL-xl and BCL-xs, compared with normal veins. Patients with varicose vein disease show increased apoptosis in the distal saphenous trunk compared with the proximal saphenous trunk, suggesting an association between chronic venous hypertension and apoptosis.

The purpose of this study was to evaluate the postactivation potentiation (PAP) effect of isometric and plyometric contractions on explosive performance of the upper and the lower limbs in male and female elite athletes. Thirteen male and ten female international level fencers performed four protocols of either isometric (3 sets of 3 sec) or plyometric (3 sets of 5 repetitions) bench and leg press, in a within subject randomized design. Before and immediately after the PAP treatment and following 4, 8, 12 min, explosive performance was measured by performing a countermovement jump (CMJ) or a bench press throw. Statistical analysis revealed significant time effect for peak leg power during the CMJ (p < 0.001) only for men, with values after the isometric PAP treatment being lower than baseline at the 8 and 12 min time points (by 7.5% (CI95% = 3.9-11.2%) and 8.7% (CI95% = 6.0-11.5%, respectively), while after the plyometric PAP treatment peak leg power remained unchanged. A significant negative correlation was found between leg strength (as expressed by 1-RM leg press performance) and the change in peak leg power between baseline and after 12 min of recovery only in male fencers (r = -0.55, p < 0.05), suggesting that stronger individuals may show a greater decrease in peak leg power. Based on the above results we conclude that lower body power performance in international level fencers may be negatively affected after isometric contractions and thus they should be advised against using isometric exercises to induce PAP with the protocol prescribed in the present study. Furthermore, gender and strength level must be considered in the practical application of PAP. © Journal of Sports Science and Medicine.

The purpose of this study was to evaluate the postactivation potentiation (PAP) effect of isometric and plyometric contractions on explosive performance of the upper and the lower limbs in male and female elite athletes. Thirteen male and ten female international level fencers performed four protocols of either isometric (3 sets of 3 sec) or plyometric (3 sets of 5 repetitions) bench and leg press, in a within subject randomized design. Before and immediately after the PAP treatment and following 4, 8, 12 min, explosive performance was measured by performing a countermovement jump (CMJ) or a bench press throw. Statistical analysis revealed significant time effect for peak leg power during the CMJ (p < 0.001) only for men, with values after the isometric PAP treatment being lower than baseline at the 8 and 12 min time points (by 7.5% (CI95% = 3.9-11.2%) and 8.7% (CI95% = 6.0-11.5%, respectively), while after the plyometric PAP treatment peak leg power remained unchanged. A significant negative correlation was found between leg strength (as expressed by 1-RM leg press performance) and the change in peak leg power between baseline and after 12 min of recovery only in male fencers (r = -0.55, p < 0.05), suggesting that stronger individuals may show a greater decrease in peak leg power. Based on the above results we conclude that lower body power performance in international level fencers may be negatively affected after isometric contractions and thus they should be advised against using isometric exercises to induce PAP with the protocol prescribed in the present study. Furthermore, gender and strength level must be considered in the practical application of PAP. © Journal of Sports Science and Medicine.

The purpose of this study was to evaluate the postactivation potentiation (PAP) effect of isometric and plyometric contractions on explosive performance of the upper and the lower limbs in male and female elite athletes. Thirteen male and ten female international level fencers performed four protocols of either isometric (3 sets of 3 sec) or plyometric (3 sets of 5 repetitions) bench and leg press, in a within subject randomized design. Before and immediately after the PAP treatment and following 4, 8, 12 min, explosive performance was measured by performing a countermovement jump (CMJ) or a bench press throw. Statistical analysis revealed significant time effect for peak leg power during the CMJ (p < 0.001) only for men, with values after the isometric PAP treatment being lower than baseline at the 8 and 12 min time points (by 7.5% (CI95% = 3.9-11.2%) and 8.7% (CI95% = 6.0-11.5%, respectively), while after the plyometric PAP treatment peak leg power remained unchanged. A significant negative correlation was found between leg strength (as expressed by 1-RM leg press performance) and the change in peak leg power between baseline and after 12 min of recovery only in male fencers (r = -0.55, p < 0.05), suggesting that stronger individuals may show a greater decrease in peak leg power. Based on the above results we conclude that lower body power performance in international level fencers may be negatively affected after isometric contractions and thus they should be advised against using isometric exercises to induce PAP with the protocol prescribed in the present study. Furthermore, gender and strength level must be considered in the practical application of PAP. © Journal of Sports Science and Medicine.

Group IIA secreted phospholipase A2 (GIIA sPLA2) is a member of the mammalian sPLA2 enzyme family and is associated with various inflammatory conditions. In this study, the synthesis of 2-oxoamides based on α-amino acids and the in vitro evaluation against three secreted sPLA2s (GIIA, GV and GX) are described. The long chain 2-oxoamide GK126 based on the amino acid (S)-leucine displayed inhibition of human and mouse GIIA sPLA2s (IC50 300 nM and 180 nM, respectively). It also inhibited human GV sPLA2 with similar potency, while it did not inhibit human GX sPLA2. The elucidation of the stereoelectronic characteristics that affect the in vitro activity of these compounds was achieved by using a combination of simulated annealing to sample low-energy conformations before the docking procedure, and molecular docking calculations.

Visible light-activated sulfur doped TiO2 nanocrystalline films were synthesized by a sol-gel method based on the self-assembly technique with nonionic surfactant to control nanostructure and an inorganic sulfur source (i.e., H2SO4). The films were characterized by UV-vis diffuse reflectance, XRD, TEM, Raman, AFM, ESEM, XPS, FT-IR, EDX, EPR and porosimetry. The results showed that the physicochemical properties of the films, such as BET surface area, porosity, crystallite size and pore size distribution could be controlled by the calcination temperature. The highest surface area, smallest crystallite size and narrow pore size distribution were obtained for sulfur doped TiO2 films calcined at 350°C, which exhibit very smooth surface with minimal roughness (<1nm). The optical absorption edge of sulfur doped TiO2 was red shifted with indirect bandgap energy of 2.94eV. Sulfur species distributed uniformly throughout the films were identified both as S2- ions related to anionic substitutional doping of TiO2 as well as S6+/S4+ cations, attributed mainly to the presence of surface sulfate groups. EPR measurements revealed a sharp signal at g=2.004, whose intensity correlated with the sulfur content and most importantly was markedly enhanced under visible light irradiation, implying the formation of localized energy states in the TiO2 band gap due to anion doping and/or oxygen vacancies. In terms of photocatalytic activity, films calcined at 350°C were the most effective for the degradation of hepatotoxin microcystin-LR (MC-LR) under visible light irradiation, while films calcined at 400°C and 500°C degraded MC-LR to a lower extent, following the evolution of the sulfur content with calcination temperature. The photocatalytic activity of the sulfur doped TiO2 film was stable during three consecutive experiments under visible light irradiation, confirming the mechanical stability and reusability of the doped nanostructured thin film photocatalysts. © 2011 Elsevier B.V.

The mechanisms governing the induction of peripheral tolerance as a result of specific immunotherapy are far from being clearly characterized. In the last 15 years, a number of studies have highlighted the tolerogenic role of regulatory T cells, blocking antibodies and anti-inflammatory cytokines such as IL-10 and TGF-β; however, the best part of our knowledge is mostly limited to mechanisms underlying the maintenance phase. By contrast, little is known regarding the very early effects seen in rush and ultrarush immunotherapy protocols. In this article, Bussmann et al. provide evidence on the possible role, first, of inhibitory receptors of the leukocyte immunoglobulin-like receptor family and, second, of the upregulation of indoleamine 2,3-dioxygenase and subsequent tryptophan starvation on the induction of specific tolerance within a few hours after the initial doses. They also suggest that the observed changes reflect the activation of protective mechanisms, which we are just beginning to understand.

The skeletal and immune systems have a complex relationship. Both systems are intimately coupled, with osteoclastogenesis and hematopoiesis occurring in the bone marrow. Bone and immune cells also share common hematopoietic precursors. Furthermore, the skeletal and immune systems share various cytokines, receptors, and transcription factors that regulate signal transduction pathways involved in osteoclastogenesis and immune system activation, including the receptor activator of nuclear factor-κΒ ligand/receptor activator of nuclear factor-κΒ/osteoprotegerin (RANKL-RANK-OPG) pathway. Cancer cells can disrupt both the skeletal and immune systems. Interaction between cancer and bone cells results in a vicious cycle of bone destruction and cancer growth. Bone remodeling generates a growth-factor-rich environment that attracts cancer cells and promotes their proliferation. In turn, cancer cells stimulate osteoclast formation and activity, resulting in additional bone resorption that further stimulates cancer cell growth. Currently available bone-targeted therapies may also modulate the immune system. Bisphosphonates such as zoledronic acid exert stimulating effects on the immune system, resulting in possible anticancer activity against malignant cells. Denosumab, an anti-RANKL monoclonal antibody with proven antiosteoclast activity, may suppress immune responses. This may result in the reported association with an increased risk of neoplasms, as well as serious skin and other infections as reported in some studies, mainly in the postmenopausal setting. When assessing bone-targeted therapies, it is important to consider the shared signaling pathways between bone and the immune system, as well as the clinical risk:benefit ratio. © 2011 Springer-Verlag.

Objectives To determine whether intermittent docetaxel might control disease while limiting the toxicity and improving the quality-of-life parameters in patients with advanced, castrate-resistant prostate cancer. Intermittent docetaxel represents an appealing therapeutic approach. Methods We reviewed the records of 35 patients with chemotherapy-naive castrate-resistant prostate cancer who had received docetaxel 45 mg/m2 every 2 weeks, with oral prednisone 5 mg twice daily. Treatment was held when the patients had reached a >50% prostate-specific antigen reduction from baseline that was confirmed by a second measurement 4 weeks later, in the absence of disease progression. Docetaxel was resumed at a >25% prostate-specific antigen increase from the nadir level, also confirmed by a second measurement 4 weeks later, or in cases of documented disease progression. Results Of the 35 patients, 18 (51.42%) had entered the first chemotherapy-free interval (CFI) after a median of 6 infusions (range 2-12), 6 patients had entered a second CFI after a median of 4 months (range 2-12), and 1 patient, a third CFI at the last follow-up point. The median interval "off chemotherapy" was 4.5 months (range 1-16) for the first CFI. Two patients discontinued docetaxel because of Grade 4 nonhematologic toxicity. The median interval to treatment failure was 8.1 months (95% confidence interval 5.1-12.2) for the entire cohort and 12.2 months (95% confidence interval 8.3-25+) for the patients who had entered the first CFI. Conclusions The results of our study have shown that intermittent docetaxel is a clinically active and likely more tolerable and less costly therapeutic strategy for patients with castrate-resistant prostate cancer than continuous administration. Additional validation of this approach is warranted. © 2011 Elsevier Inc.

The role of high-dose therapy followed by autologous stem cell transplantation (ASCT) in the treatment of multiple myeloma (MM) continues to evolve in the novel agent era. The choice of induction therapy has moved from conventional chemotherapy to newer regimens incorporating the immunomodulatory derivatives thalidomide or lenalidomide and the proteasome inhibitor bortezomib. These drugs combine well with traditional therapies and with one another to form various doublet, triplet, and quadruplet regimens. Up-front use of these induction treatments, in particular 3-drug combinations, has affected unprecedented rates of complete response that rival those previously seen with conventional chemotherapy and subsequent ASCT. Autotransplantation applied after novel-agent-based induction regimens provides further improvement in the depth of response, a gain that translates into extended progression-free survival and, potentially, overall survival. High activity shown by immunomodulatory derivatives and bortezomib before ASCT has recently led to their use as consolidation and maintenance therapies after autotransplantation. Novel agents and ASCT are complementary treatment strategies for MM. This article reviews the current literature and provides important perspectives and guidance on the major issues surrounding the optimal current management of younger, transplantation-eligible MM patients. © 2011 by The American Society of Hematology.

The aim of this double-blind, randomized control trial was to compare the effectiveness of intra-articular ropivacaine alone or with morphine or ketoprofen for controlling pain after arthroscopic knee surgery. One hundred fifty-six patients scheduled for elective knee arthroscopy were recruited. All patients received general anesthesia and were randomly assigned to 4 groups to receive intra-articular ropivacaine 40 mg (group R), ropivacaine 24 mg plus morphine 8 mg (group R+M), ropivacaine 36 mg plus ketoprofen 100 mg (group R+K), or normal saline (group N/S). Pain, sedation, orientation, nausea, vomiting, and urine retention were recorded at 0, 1, 2, 4, 8, 12, and 24 hours postoperatively. Pain was evaluated by a 10-cm visual analog scale (VAS). When the pain was >2, a suppository of 400 mg paracetamol plus 10 mg codeine plus 50 mg caffeine was given. Results showed that at 4 hours postoperatively, pain differed significantly among the 4 groups (P<.001), with less pain recorded in the R+M group. Similarly, the number of suppositories administered postoperatively to the R+M group was significantly less (P<.001) vs the other groups. Patients who received ropivacaine and morphine or normal saline had a higher incidence of nausea and vomiting vs the other groups (P=.001 and P=.036, respectively). The combination of intra-articular ropivacaine and morphine is associated with less pain after knee arthroscopy during early recovery but with a higher incidence of nausea and vomiting. However, the addition of ketoprofen to ropivacaine provides relatively satisfactory pain relief, but with fewer side effects compared to morphine.

Perioperative use of a cell saver device can serve as a cost-beneficial alternative to the transfusion method, especially in countries where the cost of a single unit of blood is high. The purpose of this study, conducted in a Greek hospital, was to calculate the cost benefit of using a cell saver device to salvage intraoperative blood during open surgical abdominal aortic aneurysm repair or open aortofemoral bypass for occlusive disease. This retrospective study measured the amounts of salvaged blood and reinfused blood encountered during the procedure and then calculated the cost benefit of cell saver use. With the cost of a unit of blood purchased in Greece about €450 ($585), the blood units salvaged and reinfused were calculated at a mean cost benefit of €754 ($980) per case.

We study theoretically the conditions under which optical bistability is achievable in a two-subband system in a semiconductor quantum well. We consider the interaction of the two-subband system with a continuous wave electromagnetic field, which induces intersubband transitions. For the description of the system dynamics we use the effective nonlinear density matrix equations. We solve these equations analytically, in the steady state, for a GaAs/AlGaAs quantum well structure. For several combinations of the values of the parameters three real solutions of the population inversion arise and the phenomenon of optical bistability prevails.

Objectives To identify the intrinsic risk factors of non-contact strains in the hamstrings and quadriceps muscles of professional soccer players via a cohort prospective design. Methods A total of 100 professional soccer players (aged 19.4–27.8 years) from four professional teams underwent a composite musculoskeletal assessment at preseason. Intrinsic risk factors included dichotomies of asymmetries in muscle strength, flexibility, proprioception, anthropometry and knee joint stability, and of previous injuries. Muscle strains were prospectively monitored during the subsequent season using questionnaires. The data were analysed via binary logistic regression.Results Thirty-eight percent of the players sustained one or more lower-extremity muscle strains. Sixteen (42.1 %) and seven (18.4 %) of them were clinically diagnosed as having non-contact muscle strains at their hamstrings and quadriceps, respectively. Players with eccentric hamstring strength asymmetries (OR=3.88; 95% CI 1.13 to 13.23), functional leg length asymmetries (OR=3.80; 95% CI 1.08 to 13.33) and no previous hamstrings injuries (OR=0.15; 95% CI 0.029 to 0.79) were at greater risk of sustaining a hamstring muscle strain. Players with eccentric strength (OR=5.01; 95% CI 0.92 to 27.14) and flexibility asymmetries (OR=4.98; 95% CI 0.78 to 31.80) in their quadriceps as well as heavier (OR=10.70; 95% CI 0.73 to 156.37) and shorter players (OR=0.08; 95% CI 0.00 to 1.35) were at greater risk of sustaining a strain in this muscle group. Conclusions Professional soccer players with functional asymmetries possess a higher risk of sustaining hamstring strains. Previous injury seems not to constitute a risk factor. The systematic isokinetic evaluation of the lower extremities during the preseason period can provide therapists and trainers with valuable data regarding the predictive elements of non-contact hamstring strains in professional soccer players.

The assessment of an aquifers’ vulnerability to pollution is of great importance, and can be used as a tool to augment planning, effective protection and management of groundwater resources’ quality, especially in the case of karstic aquifers. The present study aims to assess the intrinsic vulnerability of a karstic groundwater system, with the use of a modified version of the PI method. The assessments are functional to the effectiveness of the protective cover, as well as to the degree to which the protective cover is bypassed due to flow conditions. The used data was obtained by field work, empirical and semi-quantitative approaches regarding lithology, fissuring and karstification of bedrock, soil characteristics, hydrology, hydrogeology, topography and vegetation. The combinational effect of the above parameters, as processed with the aid of a GIS system, yielded the final calculation of the protection factor (π) and subsequently the vulnerability of the aquifer to pollution.