FurE, a member of the NCS1 family, is an Aspergillus nidulans transporter specific for uracil, allantoin and uric acid. Recently, we showed that C- or N-terminally truncated FurE versions are blocked for endocytosis and, surprisingly, show modified substrate specificities. Bifluorescence complementation assays and genetic analyses supported the idea that C- and N-termini interact dynamically and through this interaction regulate selective substrate translocation. Here we functionally dissect and define distinct motifs crucial for endocytosis, transport activity, substrate specificity and folding, in both cytosolic termini of FurE. Subsequently, we obtain novel genetic and in silico evidence indicating that the molecular dynamics of specific N- and C-terminal regions exert long range effects on the gating mechanism responsible for substrate selection, via pH-dependent interactions with other internal cytosolic loops and membrane lipids. Our work shows that expanded cytoplasmic termini, acquired through evolution mostly in eukaryotic transporters, provide novel specific functional roles.

New sedimentological, micropaleontological and geochemical data from the Upper Miocene pre-evaporitic sedimentary sequence of the Faneromeni section (Crete Island, eastern Mediterranean) revealed a stepwise restriction of the Mediterranean Sea preceding the Messinian Salinity Crisis (MSC), which was modulated by a sedimentary cyclicity responding to orbital parameters. This cyclicity is manifested by lithological alternations from laminated to indurated homogeneous marls and clayey limestones, and covers the Tortonian-Messinian Transition (TMT; 7.6–6.7 Ma). This time window covers the successive closure of the marine Mediterranean-Atlantic gateways, which culminated in the onset of the MSC. In the present study, we present the first evidence for changes in the upper water column reflected by sea surface temperature (SST) and salinity (SSS) variations that correlate with pronounced paleoclimatic fluctuations. Planktonic foraminiferal isotopes, in combination with paired mixed layer Sr/Ca-derived SST data, reveal that the very warm late Tortonian interval has been followed by a strong long-term cooling ( 10 °C) and desalination ( 10‰) trend during the earliest Messinian, attributed to the paroxysmal phase of the so-called “siphon” event. In particular, the climate shift that occurred at the end of a global carbon isotope (δ13C) decrease suggests that changes in the carbon cycle were instrumental in driving late Miocene climate dynamics (cooling and aridity) in the progressively isolated eastern Mediterranean Sea. The observed salinity variability during this time interval also provides further insights about seasonal freshwater inputs and gives new support to the much-debated hydrologic regime (linear salinity increase vs step-function evolution with strong salinity fluctuations) preceding the deposition of evaporites. The novel methodology of foraminiferal Sr/Ca paleothermometry and results of this study could have numerous potential applications to other regions and relevant extreme geological events. Therefore, in the near future we expect this approach to add important new information to our understanding of Neogene climates.

Aims: We use new deep XMM-Newton observations of the northern disk of M 31 to trace the hot interstellar medium (ISM) in unprecedented detail and to characterise the physical properties of the X-ray emitting plasmas. Methods: We used all XMM-Newton data up to and including our new observations to produce the most detailed image yet of the hot ISM plasma in a grand design spiral galaxy such as our own. We compared the X-ray morphology to multi-wavelength studies in the literature to set it in the context of the multi-phase ISM. We performed spectral analyses on the extended emission using our new observations as they offer sufficient depth and count statistics to constrain the plasma properties. Data from the Panchromatic Hubble Andromeda Treasury were used to estimate the energy injected by massive stars and their supernovae. We compared these results to the hot gas properties. Results: The brightest emission regions were found to be correlated with populations of massive stars, notably in the 10 kpc star-forming ring. The plasma temperatures in the ring regions are ~0.2 keV up to ~0.6 keV. We suggest this emission is hot ISM heated in massive stellar clusters and superbubbles. We derived X-ray luminosities, densities, and pressures for the gas in each region. We also found large extended emission filling low density gaps in the dust morphology of the northern disk, notably between the 5 kpc and 10 kpc star-forming rings. We propose that the hot gas was heated and expelled into the gaps by the populations of massive stars in the rings. Conclusions. It is clear that the massive stellar populations are responsible for heating the ISM to X-ray emitting temperatures, filling their surroundings, and possibly driving the hot gas into the low density regions. Overall, the morphology and spectra of the hot gas in the northern disk of M 31 is similar to other galaxy disks.

PURPOSE: Bladder cancer represents a major cause of malignancy-related morbidity and the most expensive per-patient-to-treat cancer, due to the lifelong surveillance of the patients. Accurate disease prognosis is essential in establishing personalized treatment decisions; yet optimum tools for precise risk stratification remain a competing task. In the present study, we have performed the complete evaluation of TP63 clinical significance in improving disease prognosis. METHODS: The levels of DeltaNp63 and TAp63 transcripts of TP63 were quantified in 342 bladder tissue specimens of our screening cohort (n = 182). Hedegaard et al. (Cancer Cell 30:27-42. doi:10.1016/j.ccell.2016.05.004, 2016) (n = 476) and TCGA provisional (n = 413) were used as validation cohorts for NMIBC and MIBC, respectively. Survival analysis was performed using recurrence and progression for NMIBC or mortality for MIBC as endpoint events. Bootstrap analysis was performed for internal validation, while decision curve analysis was used for the evaluation of the clinical net benefit on disease prognosis. RESULTS: DeltaNp63 was significantly expressed in bladder tissues, and was found to be over-expressed in bladder tumors. Interestingly, reduced DeltaNp63 levels were correlated with muscle-invasive disease, high-grade tumors and high-EORTC-risk NMIBC patients. Moreover, DeltaNp63 loss was independently associated with higher risk for NMIBC relapse (HR = 2.730; p = 0.007) and progression (HR = 7.757; p = 0.016). Hedegaard et al. and TCGA validation cohorts confirmed our findings. Finally, multivariate models combining DeltaNup63 loss with established prognostic markers led to a superior clinical benefit for NMIBC prognosis and risk stratification. CONCLUSIONS: DeltaNup63 loss is associated with adverse outcome of NMIBC resulting in superior prediction of NMIBC early relapse and progression.

(Abridged) The Maunakea Spectroscopic Explorer (MSE) is an end-to-end science platform for the design, execution and scientific exploitation of spectroscopic surveys. It will unveil the composition and dynamics of the faint Universe and impact nearly every field of astrophysics across all spatial scales, from individual stars to the largest scale structures in the Universe. Major pillars in the science program for MSE include (i) the ultimate Gaia follow-up facility for understanding the chemistry and dynamics of the distant Milky Way, including the outer disk and faint stellar halo at high spectral resolution (ii) galaxy formation and evolution at cosmic noon, via the type of revolutionary surveys that have occurred in the nearby Universe, but now conducted at the peak of the star formation history of the Universe (iii) derivation of the mass of the neutrino and insights into inflationary physics through a cosmological redshift survey that probes a large volume of the Universe with a high galaxy density. MSE is positioned to become a critical hub in the emerging international network of front-line astronomical facilities, with scientific capabilities that naturally complement and extend the scientific power of Gaia, the Large Synoptic Survey Telescope, the Square Kilometer Array, Euclid, WFIRST, the 30m telescopes and many more.

The Ingessana hills in the southern Blue Nile of Sudan consist of serpentinised and highly silicified dunites in contact with the intruding Bau granite. The observed chromite mineralization zones are associated with NE-SW trending shear-zones. The mineralization associated with ophiolitic belts includes podiform chromite, asbestos, talc, and base metal (Cu, Ni, Co) mineralization. We applied Linear Spectral Unmixing algorithm on a 10m spatial resolution Sentinel-2 images in order to detect and map the chromite mineralization and the associated mineralization of ophiolitic belts. The resulting abundance maps show the capability of Sentinel-2 for detailed mineral mapping and detection of potential chromite ore deposit locations.

 

 Pediatric Allergy and Immunology (PAI) 2019, 30(3):296-304.

We propose 200 ks total ACIS-S observations of the spiral galaxy NGC 2336, one of the most actively star-forming galaxies in the local Universe. The proposed observations will reach Lx 7 x 10^{37} erg/s, yielding over 40 high-mass X-ray binaries (XRBs). Archival UV data and supporting Hubble Space Telescope observations fully leverage our proposed Chandra observations by allowing us to: (a) measure the age and metallicity distribution of young XRBs; (b) measure the formation efficiency of young XRBs as a function of the age of their parent stellar populations; (c) constrain XRB formation models; (d) characterize the ultra-luminous XRB population; (e) explore the role of star formation in energizing the ISM; and (f) identify the nature of the nuclear source.

Earthquake scenarios were applied towards seismic risk assessment in the earthquake prone city of Aigion (W. Corinth Gulf), by combining deterministic seismic hazard and empirical structural vulnerability. Ground motions for three hazardous fault sources for Aigion were generated using a finite source stochastic simulation technique, taking into account the well-established seismotectonics of the area and site effects derived from ambient noise horizontal-to-vertical-spectral-ratios (HVSR). Validation of the parameters of the stochastic simulation and the estimated damage was performed with respect to real recordings and the damage database of a past seismic event in the area. Vulnerability was assessed empirically for an exposure model comprising 3200 buildings, compiled with on site and remoted techniques. The European Macroseismic Scale (EMS-98) was used to describe the ground motion severity in terms of macroseismic intensity and the taxonomy of the building stock into 7 structural types. Seismic risk was spatialized using GIS mapping tools on a building block scale in terms of EMS-98 damage grades and their maximum probability of occurrence. The obtained risk assessment models indicate that the northeastern and partly the southern part of Aigion are more susceptible to damage, in accordance with damage distribution from the most recent Mw6.4 disastrous earthquake for the city in 1995, the site amplification inferred from HVSR, and the assessed vulnerability of the constructions. Nevertheless, the current building stock demonstrates significantly enhanced seismic behaviour, due to rehabilitation after the 1995 earthquake. Despite unavoidable uncertainties, intrinsic to both the method and data, the herein seismic risk assessment appears realistic and consistent, thus allowing its exploitation towards loss estimation and mitigation scenarios.

The study of the east dipping N-S mountain front of Olympus Mt that is presented in this work, was based on the interpretation of high-resolution digital elevation model (DEM), as the main dataset for calculating various tectonic geomorphology indices, through quantitative techniques. Since the fluvial network maintains its connection to the tectonic forcing and therefore contains potentially useful information about variations in rock uplift rates across the landscape, we used a highly detailed one generated from the DEM in order to calculate various indices and extract quantitate information. Calculations were made in a GIS platform by using the Ks index, the drainage basin asymmetry index and the geometry of the triangular facets on the front of the mountain, alongside the fault zone delineating the mountain. The results extracted by combining the previous methodologies are in agreement with the observations which were made during the fieldwork, that there is no uniform uplift along the main Olympus fault zone.

A web - interactive application which spreads geo-environmental information over the internet and also accepts and manages real time rural data is described in this paper. Story Maps context has been chosen for this reason, since this is considered to be a new and innovative Web-based Geographic Information System application method for using it as a mean for organizing and presenting new digital geographic information by combining interactive maps with multimedia and other apps simultaneously in one platform. The protected area of Kallidromo Mt. (central Greece) was chosen as a case study, due to its environmental sensitivity since it is characterized as Natura protected area and also because of the availability of several kinds of geospatial data.

Little research has been conducted on emerging adulthood in Greece, although sociodemographic specificities and constraints due to financial crisis are expected to reinforce prolonged transition to adulthood in this Southern European country. Using a person-centered approach, the current study aimed to examine dimensions of emerging adulthood, criteria for adulthood, and identity development among studying youth in association with personal and structural variables (i.e., gender, age, living arrangement, work experience, steady romantic relationship status, and financial adversity). Participants were 814 university students (Mage = 19.9 years). Latent profile analysis yielded five profiles: anxious explorers in-between (29.90%), immature explorers (29.58%), emerging adults (18.30%), adult committers (12.58%), and blocked in transition (9.64%). Significant between-profile differentiation was found regarding all variables except from age and work experience. The results support the existence of emerging adulthood in Greece and indicate diverse paths to adulthood within the rather homogeneous population of studying youth in this country.

We present the results of the photometric analysis of a large part of the main body of the Small Magellanic Cloud. Using the 6.5m Magellan Telescope at the Las Campanas Observatory in Chile, we have acquired deep B and I images in four fields (0.44 deg each in diameter), yielding accurate photometry for 1068 893 stars down to 24th magnitude, with a spatial resolution of 0.20 arcsec per pixel. Colour-magnitude diagrams and (completeness-corrected) luminosity functions have been constructed, yielding significant new results that indicate at least two discrete star formation events over a period from 2.7 to 4 Gyr ago. Also, we have derived star formation rates as a function of look-back time and have found enhancements of SF between 4 and 6 Gyr and at younger ages.

Electrons in the outer Van Allen (radiation) belt occasionally reach relativistic energies, turning them into a potential hazard for spacecraft operating in geospace. Such electrons have secured the reputation of satellite killers and play a prominent role in space weather. The flux of these electrons can vary over time scales of years (related to the solar cycle) to minutes (related to sudden storm commencements). Electric fields and plasma waves are the main factors regulating the electron transport, acceleration and loss. Both the fields and the plasma waves are driven directly or indirectly by disturbances originating in the Sun, propagating through interplanetary space and impacting the Earth. This paper reviews our current understanding of the response of outer Van Allen belt electrons to solar eruptions and their interplanetary extensions, i.e. interplanetary coronal mass ejections and high-speed solar wind streams and the associated stream interaction regions.

ISO15189:2012 requires medical laboratories to document metrological traceability of their results. While the ISO17511:2003 standard on metrological traceability in laboratory medicine requires the use of the highest available level in the traceability chain, it recognizes that for many measurands there is no reference above the manufacturer's selected measurement procedure and the manufacturer's working calibrator. Some immunoassays, although they intend to measure the same quantity and may even refer to the same reference material, unfortunately produce different results because of differences in analytical selectivity as manufacturers select different epitopes and antibodies for the same analyte. In other cases, the cause is the use of reference materials, which are not commutable. The uncertainty associated with the result is another important aspect in metrological traceability implementation. As the measurement uncertainty on the clinical samples is influenced by the uncertainty of all steps higher in the traceability chain, laboratories should be provided with adequate and appropriate information on the uncertainty of the value assignment to the commercial calibrators that they use. Although the between-lot variation in value assignment will manifest itself as part of the long-term imprecision as estimated by the end-user, information on worst-case to be expected lot-lot variation has to be communicated to the end-user by the IVD provider. When laboratories use ancillary equipment that potentially could have a critical contribution to the reported results, such equipment needs verification of its proper calibration and criticality to the result uncertainty could be assessed by an approach based on risk analysis, which is a key element of ISO15189:2012 anyway. This paper discusses how the requirement for metrological traceability as stated in ISO15189 should be met by the medical laboratory and how this should be assessed by accreditation bodies

The eclipsing binary system DV Psc has been known to be magnetically active for almost two decades. However, there has been no evidence of a magnetic cycle on this system until recently. This study focuses on the long-term photometric monitoring of DV Psc between 2005-2017. A total of 50 individual light curves in BVRI optical bands were collected, in order to investigate its magnetic activity and cycle, as well as determine its orbital and physical properties. The combined photometric and spectroscopic observations of this study resulted in a unified model for the system, which describes accurately the light curves throughout the years, as a result of the variable spot activity. A total of 105 new times of minimum light are calculated through the entire time span of observations and they are combined with the 203 bibliographic ones since 1997, increasing significantly the existing sample. This resulted in an accurate ephemeris and an updated O-C diagram for a total span of 20 yr (1997-2017). It is found that the system exhibits intense magnetic activity, which is shown through the strong asymmetries on the light curves (O'Connell effect) and the periodic variation of the O-C diagram. The existence of a third body, orbiting the eclipsing binary with a period of Porb=9.79±0.60 yr in an eccentric orbit with eccentricity e=0.83±0.24, as well as a magnetic cycle of 14.74±0.84 yr are most likely connected with this variability. The absolute physical parameters of the system are calculated for a new and unified model, which explains the light curves through the entire observing season. The evolution state of DV Psc is studied through the mass-radius and temperature-luminosity (HR) diagrams, as well as the location of the two components with respect to the ZAMS and TAMS region.

 

Developing educational material based on satellite remote sensing technologies, information and methods, is a key trend in modern pedagogy of Earth System Sciences. Here, we present “MICE”, a classroom activity on Melting ICe Effects, that utilizes remote sensing information to demonstrate the value of Earth Observation (EO) as a context to teach the STEM (Science, Technology, Engineering and Mathematics) school curriculum. The activity focuses on the subject of polar ice melting as a main climate change effect and the different impact of land and sea ice melting on sea level rise. Students, have the opportunity to discover the above experimentally and subsequently, to observe the diachronic change on polar ice through sequences of satellite images and discover the positive climate feedback on global warming. The activity was translated and adapted to the Greek curriculum from the freely available classroom resources of the European Space Agency (ESA, “Teach with Space” collection). MICE, has been enriched with Greek scientific material, including up-to-date information on climate impacts, localized for the extended region. As part of an evolutionary process, the activity was pilot-tested with 6th grade primary school students and adjusted according to the trial findings. This work is considered as the first step towards the development of original Greek educational material that will utilize EO and climate change as the context to teach STEM school curriculum, capitalizing on the pedagogical role satellite remote sensing and inquiry-based teaching methods, can play.

Developing educational material based on satellite remote sensing technologies, information and methods, is a key trend in modern pedagogy of Earth System Sciences. Here, we present “MICE”, a classroom activity on Melting ICe Effects, that utilizes remote sensing information to demonstrate the value of Earth Observation (EO) as a context to teach the STEM (Science, Technology, Engineering and Mathematics) school curriculum. The activity focuses on the subject of polar ice melting as a main climate change effect and the different impact of land and sea ice melting on sea level rise. Students, have the opportunity to discover the above experimentally and subsequently, to observe the diachronic change on polar ice through sequences of satellite images and discover the positive climate feedback on global warming. The activity was translated and adapted to the Greek curriculum from the freely available classroom resources of the European Space Agency (ESA, “Teach with Space” collection). MICE, has been enriched with Greek scientific material, including up-to-date information on climate impacts, localized for the extended region. As part of an evolutionary process, the activity was pilot-tested with 6th grade primary school students and adjusted according to the trial findings. This work is considered as the first step towards the development of original Greek educational material that will utilize EO and climate change as the context to teach STEM school curriculum, capitalizing on the pedagogical role satellite remote sensing and inquiry-based teaching methods, can play.

The synergy of different methods was used for the creation of an earthquake-induced landslides (EIL) inventory for the Ionian Islands. More specifically, post-earthquake field surveys were conducted shortly after recent earthquakes (2003 and 2015 in Lefkada, 2014 in Cephalonia and 2018 in Zakynthos) in order to obtain detailed field information of the EIL among other earthquake effects. The available literature on historical earthquakes were reexamined with emphasis on their environmental effects and especially EIL. Remote sensing products including satellite imagery and orthophotos were interpreted. All qualitative and quantitative information related to EIL and derived from the aforementioned steps were inserted in a database especially designed and developed in GIS environment for the purpose of this study and the respective inventory map was produced. This landslide inventory map was used and combined with other thematic maps in order to test the earthquake-induced landslide susceptibility (LS) of the Ionian Islands. The Analytical Hierarchical Process was applied along with the Weighted Linear Combination method in the frame of a multi-criteria decision analysis for the calculation of the spatial distribution of the Landslide Susceptibility Index (LSI). Along with the inventory, morphological data were derived from a TanDEM-X elevation model of the Ionian Islands based on data produced by TanDEM-X and TerraSAR-X satellite pair. Lithological and geological data were digitized from previous already published geological and neotectonic maps updated with corrections from field mapping for the purpose of this study. Land use and soil thickness were derived from the 2018 version of Corine Land Cover. Road network was digitized from the topographic maps of the Hellenic Military Geographical Service, while rainfall data was collected from the database of the National Meteorological Service. Data classification of each factor according to their estimated LS followed, by using the reverse ranking method, where 1 is the least and 10 is the most susceptible. Each category was normalized to 100% and the final raster thematic maps of landslide controlling factors were produced. Finally, using numerical weight for each factor, which was assigned by the Analytic Hierarchy Process using Pairwise Comparison Method and according to the weighted linear combination, a map was generated where each cell has a certain LSI value. The higher the LSI value, the higher the LS, whereas lower LSI value means lower LS. The resulted map, classified with natural breaks method, constitutes the earthquake-induced LS map of the Ionian Islands with five LS categories: very low, low, moderate, high and very high LS. Comparison of the EIL inventory map and the LS map show that the EIL in the Ionian Islands are structurally controlled as the majority of them have been generated along morphological discontinuities formed by active faults or inactive thrusts and overthrusts.

This paper examines the effects of the unconventional monetary policy (UMP) launched by the European Central Bank on the cross-market correlations between bond, stock and currency forward markets. Using a dynamic conditional correlation analysis and several robustness tests, we investigate possible differences on the correlation dynamics across four UMP periods and across a range of developed countries and emerging market economies. The empirical results indicate a spillover effect on both developed and emerging markets, although this impact is not identical across assets and countries. We also find that the new UMP phase started in 2014 has a more prominent impact, highlighting differences on the impact between the earlier and the new wave of UMPs and across cross-market correlations.

This paper examines the impact of the four unconventional monetary policy announcements followed by the European Central Bank on the stock price of European banks, as well as on the STOXX Europe 600 Banks index, from January 2010 to December 2016. The results show that there is a positive relation between the announced programs and the stock returns of the European banks at the same day of the announcement, while the impact is stronger for the long-term sovereign bond purchases (Securities Markets Programme). We also find that the banks of the countries which benefit most from the unconventional policies are these from Southern Europe. On the contrary, the announcement of these programs displays a limited effect on the banks of the European core countries and those with solid banking system. Finally, the announcements seem to reduce the volatility of stock prices and especially for the Covered Bond Purchase Programme (CBPP3).

BACKGROUND: Hepatitis C virus (HCV) is a leading cause of worldwide liver-related morbidity and mortality. The World Health Organization released an integrated strategy targeting HCV-elimination by 2030. This study aims to estimate the required interventions to achieve elimination using updated information for direct-acting antiviral (DAA) treatment coverage, to compute the total costs (including indirect/societal costs) of the strategy and to identify whether the elimination strategy is cost-effective/cost-saving in Greece. AIM: To estimate the required interventions and subsequent costs to achieve HCV elimination in Greece. METHODS: A previously validated mathematical model was adapted to the Greek HCV-infected population to compare the outcomes of DAA treatment without the additional implementation of awareness or screening campaigns versus an HCV elimination strategy, which includes a sufficient number of treated patients. We estimated the total costs (direct and indirect costs), the disability-adjusted life years and the incremental cost-effectiveness ratio using two different price scenarios. RESULTS: Without the implementation of awareness or screening campaigns, approximately 20000 patients would be diagnosed and treated with DAAs by 2030. This strategy would result in a 19.6% increase in HCV-related mortality in 2030 compared to 2015. To achieve the elimination goal, 90000 patients need to be treated by 2030. Under the elimination scenario, viremic cases would decrease by 78.8% in 2030 compared to 2015. The cumulative direct costs to eliminate the disease would range from 2.1-2.3 billion euros (euro) by 2030, while the indirect costs would be euro1.1 billion. The total elimination cost in Greece would range from euro3.2-3.4 billion by 2030. The cost per averted disability-adjusted life year is estimated between euro10100 and euro13380, indicating that the elimination strategy is very cost-effective. Furthermore, HCV elimination strategy would save euro560-895 million by 2035. CONCLUSION: Without large screening programs, elimination of HCV cannot be achieved. The HCV elimination strategy is feasible and cost-saving despite the uncertainty of the future cost of DAAs in Greece.

Superimpositions of serial 3D dental surface models comprise a powerful tool to assess morphological changes due to growth, treatment, or pathology. In this study, we evaluated the effect of artifacts on the superimposition outcome, using standard model acquisition and superimposition techniques. Ten pre- and post-orthodontic treatment plaster models were scanned with an intraoral scanner and superimposed using the iterative closest point algorithm. We repeated the whole process after manual removal of plaster artifacts, according to the current practice, as well as after re-scanning the cleaned models, to assess the effect of the model acquisition process derived artifacts on the superimposition outcome. Non-parametric multivariate models showed no mean effect on accuracy and precision by software settings, cleaning status (artifact removal), or time point. The choice of the superimposition reference area was the only factor that affected the measurements. However, assessment of individual cases revealed significant differences on the detected tooth movement, depending on artifact removal and on the model acquisition process. The effects of all factors tended to decrease with an increase in the size of the superimposition reference area. The present findings highlight the importance of accurate, artifact-free models, for valid assessment of morphological changes through serial 3D model superimpositions.

BACKGROUND: Major depression is associated with endothelial dysfunction and arterial stiffening, which may mediate development of hypertension and increased cardiovascular risk. The effect of response to antidepressant treatment on these vascular parameters has not been elucidated. AIMS: We aimed to assess the net effect of antidepressant therapy on endothelial function and arterial stiffness in patients with psychotic depression. METHOD: Thirty-seven patients with major psychotic depression, according to DSM-IV-TR, were treated with titrated citalopram 20-60 mg and risperidone 0.5-1 mg and were followed for 6 months. Twelve additional patients who denied treatment, or were non-compliant, were also followed for the same time period. Vascular function was assessed by flow-mediated dilatation (FMD), carotid-femoral pulse wave velocity (PWV) and augmentation index (AI), at baseline and at the end of follow-up. RESULTS: Aortic and peripheral blood pressure (BP), PWV, FMD and AI (p < 0.05 for all) were significantly improved in the group that received treatment. Overall, only responders to treatment (n = 24) presented significant improvements in all hemodynamic and vascular parameters (p < 0.05 for all), irrespectively of traditional cardiovascular risk factors (TRFs), vasoactive medication and BP lowering. In a secondary analysis, patients with psychotic depression presented worse endothelial function as compared to controls matched for TRFs. LIMITATIONS: Non-randomized study. CONCLUSIONS: Patients who respond to therapy for major psychotic depression present sustained improvement in vascular function. Given that depressed patients are considered to be at high cardiovascular risk and are often non-compliant with treatment, further research to assess cardiovascular benefits of vigilant monitoring of antidepressant therapy is warranted.

BACKGROUND: Major depression is associated with endothelial dysfunction and arterial stiffening, which may mediate development of hypertension and increased cardiovascular risk. The effect of response to antidepressant treatment on these vascular parameters has not been elucidated. AIMS: We aimed to assess the net effect of antidepressant therapy on endothelial function and arterial stiffness in patients with psychotic depression. METHOD: Thirty-seven patients with major psychotic depression, according to DSM-IV-TR, were treated with titrated citalopram 20-60 mg and risperidone 0.5-1 mg and were followed for 6 months. Twelve additional patients who denied treatment, or were non-compliant, were also followed for the same time period. Vascular function was assessed by flow-mediated dilatation (FMD), carotid-femoral pulse wave velocity (PWV) and augmentation index (AI), at baseline and at the end of follow-up. RESULTS: Aortic and peripheral blood pressure (BP), PWV, FMD and AI (p < 0.05 for all) were significantly improved in the group that received treatment. Overall, only responders to treatment (n = 24) presented significant improvements in all hemodynamic and vascular parameters (p < 0.05 for all), irrespectively of traditional cardiovascular risk factors (TRFs), vasoactive medication and BP lowering. In a secondary analysis, patients with psychotic depression presented worse endothelial function as compared to controls matched for TRFs. LIMITATIONS: Non-randomized study. CONCLUSIONS: Patients who respond to therapy for major psychotic depression present sustained improvement in vascular function. Given that depressed patients are considered to be at high cardiovascular risk and are often non-compliant with treatment, further research to assess cardiovascular benefits of vigilant monitoring of antidepressant therapy is warranted.

© 2019 American Psychological Association. Anxiety is a common and debilitating condition, which tends to follow a chronic course if left untreated. While studies have provided evidence that yoga is an effective mind-body intervention for a variety of psychological symptoms, more meta-analytic evidence supporting yoga's efficacy specifically for anxiety symptoms is needed. The aim of this study was to investigate the effect of yoga on anxiety symptoms using meta-analytic methods. A systematic search was conducted for randomized controlled trials (RCTs) on yoga and anxiety on electronic databases over key terms. Risk of bias was assessed using the Cochrane tool. Outcome data were extracted from eligible studies, and moderators were coded across studies to indicate differences in study sample, delivery method, and type of dependent variable. Effect size aggregation and omnibus analyses, as well as moderator tests, were performed. A total of 38 RCTs (N = 2,295 adults) met inclusion criteria. Yoga practice had a large and statistically significant effect on anxiety symptoms compared with control conditions (d = 0.80). In subomnibus analyses, statistically significant effects of the yoga intervention were detected on biological measures (d = 0.45), nonanxiety mental health outcomes (d = 0.55), physical health measures (d = 0.45), and mental and physical health outcomes combined (d = 0.65). Significant moderation was found by study location, with the largest effects appearing in Indian samples. Results suggest that yoga significantly decreases anxiety symptoms, while it appears to have an ameliorative effect on psychological symptoms more globally.

BACKGROUND: For people living with HIV, major guidelines in high-income countries recommend testing for transmitted drug resistance (TDR) to guide the choice of first-line antiretroviral therapy (ART). However, individuals who fail a first-line regimen can now be switched to one of several effective regimens. Therefore, the virological and clinical benefit of TDR testing needs to be evaluated. METHODS: We included individuals from the HIV-CAUSAL Collaboration who enrolled <6 months of HIV diagnosis between 2006 and 2015, were ART-naive, and had measured CD4 count and HIV-RNA. Follow-up started at the date when all inclusion criteria were first met (baseline). We compared 2 strategies: (1) TDR testing within 3 months of baseline versus (2) no TDR testing. We used inverse probability weighting to estimate the 5-year proportion and hazard ratios (HRs) of virological suppression (confirmed HIV-RNA <50 copies/mL), and of AIDS or death under both strategies. RESULTS: Of 25,672 eligible individuals (82% males, 52% diagnosed in 2010 or later), 17,189 (67%) were tested for TDR within 3 months of baseline. Of these, 6% had intermediate- or high-level TDR to any antiretroviral drug. The estimated 5-year proportion virologically suppressed was 77% under TDR testing and 74% under no TDR testing; HR 1.06 (95% confidence interval: 1.03 to 1.19). The estimated 5-year risk of AIDS or death was 6% under both strategies; HR 1.03 (95% confidence interval: 0.95 to 1.12). CONCLUSIONS: TDR prevalence was low. Although TDR testing improved virological response, we found no evidence that it reduced the incidence of AIDS or death in first 5 years after diagnosis.

BACKGROUND: It has been suggested that the use of window functions, other than the rectangular, in the sliding window method, may be beneficial for reducing the effects of motion-related outliers in the time-series, when assessing dynamic functional connectivity (dFC) in resting-state fMRI (rs-fMRI). METHODOLOGY: Ten window functions for a wide range of window lengths (20-150 s) combined with Pearson and Kendall correlation metrics, were investigated. One hundred high quality rs-fMRI datasets from healthy controls, were used to systematically assess the effect of varying the window function and length on dFC assessment. To this end, two approaches were implemented: a) simulated outliers were added to the experimental data and b) the experimental data were divided into low and high motion subgroups. RESULTS: The presence of experimental motion-noise tended to inflate the number of dynamic connections for longer (≥100 s) wide-shaped windows, while shorter (20-30 s) narrow-shaped windows exhibited increased sensitivity in the presence of simulated outliers. Moreover, window sizes from 60 s to 90 s were mildly affected by motion-related effects. In most cases, the number of dynamic connections increased, and gradually lower frequencies were captured, with an increasing window size. CONCLUSIONS: Subject motion considerably affects the obtained dFC patterns; thus, it is preferable to perform motion artefact removal in the pre-processing stage rather than using alternative window functions to mitigate their effects. Provided that motion-noise is not excessive, the choice of a rectangular window is adequate. Finally, low frequency oscillations in functional connectivity seem to play an important role in the context of dFC assessment.

Magnetoelectric (ME) composites that exhibit both ferroelectric and ferromagnetic properties have attracted significant attention, thanks to their potential applications, e.g., low-energy-consumption storage devices. Here, we study bulk composites based on Pb(Zr0.52Ti0.48)O-3 (PZT) as a piezoelectric (PE) matrix and Fe3O4 nanoparticles (NPs) as soft ferromagnetic (FM) and magnetostrictive additives, in the form PZT-xFe(3)O(4) with 0%<= x <= 50wt.%, all sintered at T=1000 degrees C for 2h in air. We focus our study on a completely insulating sample x=5% and measure its properties at room temperature upon an out-of-plane external electric field, E-ex: namely, piezoelectric response [in-plane strain, S(E-ex)], polarization [P(E-ex)], and relaxation of the remanent magnetization, [m(rem)(t,E-ex)], prepared upon application and removal of an external magnetic field. The peaks observed in the butterflylike S(E-ex) curves at E-peak(+/-)=+/- 6kV/cm and the nucleation field recorded in the P(E-ex) loops at the same range around E-nuc(+/-)=+/- 6kV/cm (both referring to the PZT PE matrix) are clearly imprinted on the relaxation behavior of the m(rem)(t,E-ex) data (referring to the Fe3O4 FM NPs). This experimental fact proves the ME coupling between the PZT matrix and the embedded Fe3O4 NPs. We ascribe this feature to the comparable piezoelectricity of the PZT matrix and the magnetostriction of the Fe3O4 NPs that probably motivate and/or promote a strain transfer mechanism occurring at the PZT matrix-Fe3O4 NP interfaces. Our work proves that the low cost PZT-xFe(3)O(4) composite is a promising candidate ME material for future studies, aiming to potential applications.

For many decades classical anti-tumor therapies included chemotherapy, radiation and surgery; however, in the last two decades, following the identification of the genomic drivers and main hallmarks of cancer, the introduction of therapies that target specific tumor-promoting oncogenic or non-oncogenic pathways, has revolutionized cancer therapeutics. Despite the significant progress in cancer therapy, clinical oncologists are often facing the primary impediment of anticancer drug resistance, as many cancer patients display either intrinsic chemoresistance from the very beginning of the therapy or after initial responses and upon repeated drug treatment cycles, acquired drug resistance develops and thus relapse emerges, resulting in increased mortality. Our attempts to understand the molecular basis underlying these drug resistance phenotypes in pre-clinical models and patient specimens revealed the extreme plasticity and adaptive pathways employed by tumor cells, being under sustained stress and extensive genomic/proteomic instability due to the applied therapeutic regimens. Subsequent efforts have yielded more effective inhibitors and combinatorial approaches (e.g. the use of specific pharmacologic inhibitors with immunotherapy) that exhibit synergistic effects against tumor cells, hence enhancing therapeutic indices. Furthermore, new advanced methodologies that allow for the early detection of genetic/epigenetic alterations that lead to drug chemoresistance and prospective validation of biomarkers which identify patients that will benefit from certain drug classes, have started to improve the clinical outcome. This review discusses emerging principles of drug resistance to cancer therapies targeting a wide array of oncogenic kinases, along with hedgehog pathway and the proteasome and apoptotic inducers, as well as epigenetic and metabolic modulators. We further discuss mechanisms of resistance to monoclonal antibodies, immunomodulators and immune checkpoint inhibitors, potential biomarkers of drug response/drug resistance, along with possible new therapeutic avenues for the clinicians to combat devastating drug resistant malignancies. It is foreseen that these topics will be major areas of focused multidisciplinary translational research in the years to come.

Je fais partie de ceux qui aiment la vie. J’ai eu le bonheur d’avoir de bons parents, de fonder une famille heureuse... Toute ma vie, j’ai travaillé à des tâches passionnantes : j’ai aimé mes études, j’ai fait avec joie de l’enseignement et de la recherche... Je ne cesse de m’intéresser à la vie du monde, à la promotion de la femme, au maintien de la paix. Je fais confiance aux possibilités de l’homme et je crois au progrès. Je ne demande qu’à travailler, c’est-à-dire à vivre jusqu’à l’extinction de mes forces. Itinéraire de vie singulier que celui d’Eugénie Cotton. Il s’étend sur deux siècles et trois Républiques, traverse deux grandes guerres, connaît l’âge d’or et l’écroulement d’un Empire colonial. Scientifique et intellectuelle, Cotton pénétra, au début du XXe siècle, dans des territoires perçus alors comme exclusivement masculins. Femme de tête sous le Front populaire, elle réforma l’École normale supérieure de jeunes filles. Dirigeante en pleine guerre froide de grandes organisations procommunistes, féminines ou mixtes, elle fut partie prenante d’un univers à la fois international et transnational de luttes sociales, politiques et féministes. Autant d’histoires d’une vie et d’un siècle racontées « à la manière d’une passionnante enquête ».

We analyze the engineering of subwavelength nanoantennas composed of anisotropic nanospheroids, for the development of photonic devices. Instead of using conventional isotropic dielectrics, we introduce resonant anisotropic nanoparticles, allowing for shifting Kerker condition points further inside the visible. To address this study, we construct a perturbation-based discrete eigenfunction method, for the electromagnetic scattering of a plane wave by a prolate or oblate uniaxial anisotropic spheroid. The method is fast and yields the solution for the bistatic radar and total scattering cross sections, which is valid for small eccentricities of the spheroid. The validity of this technique is verified by the alternative general purpose discrete dipole approximation method. We investigate the engineering of subwavelength nanoantennas due to material and geometry shaping, like the change of anisotropy type, anisotropy ratio, and deviation of the nanoantenna from sphericity. © 1995-2012 IEEE.

Cannabinoid administration during adolescence affects various physiological processes, such as motor and affective response, cognitive-related functions and modulates neurotransmitter activity. Literature remains scant concerning the parallel examination of the effects of adolescent escalating low-dose Δ -tetrahydrocannabinol (Δ -THC) on the behavioral and plasticity profile of adult rats in both sexes. Herein, we investigated the long-term behavioral, neurochemical and neurobiological effects of adolescent escalating low Δ -THC doses in adult male and female rats. In adult males, adolescent low-dose Δ -THC exposure led to increased spontaneous locomotor activity, impaired behavioral motor habituation and defective short-term spatial memory, paralleled with decreased BDNF protein levels in the prefrontal cortex. In this brain area, serotonergic activity was increased, as depicted by the increased serotonin turnover rate, while the opposite effect was observed in the hippocampus, a region where SERT levels were enhanced by Δ -THC, compared with vehicle. In adult females, adolescent Δ -THC treatment led to decreased spontaneous vertical activity and impaired short-term spatial memory, accompanied by increased BDNF protein levels in the prefrontal cortex. Present findings emphasize the key role of adolescent escalating low Δ -THC exposure in the long-term regulation of motor response, spatial-related cognitive functions and neuroplasticity indices in adulthood. In this framework, these changes could, at a translational level, contribute to clinical issues suggesting the development of psychopathology in a sex-differentiated manner following Δ -THC exposure during adolescence.

Reconstruction of the central band of the interosseous membrane is an emerging procedure implemented in the treatment of longitudinal radioulnar dissociation (LRUD), usually in its chronic setting, after Essex-Lopresti injuries of the forearm.There are no sufficient clinical data to support reconstruction of the central band of the interosseous membrane in acute LRUD injuries.Clinical and cadaveric studies comparing autografts (palmaris longus, flexor carpi radialis and bone-patellar-bone), allografts (Achilles tendon) and synthetic ligaments have not shown superiority of one technique another; however, they have shown special concerns with respect to the use of synthetic grafts.Latrogenic fracture, decrease of rotational range of movement, iatrogenic nerve injury (superficial radial and median nerve), donor site morbidity with autografts and recurrent instability are the complications reported in literature after interosseous membrane reconstruction. Cite this article: 2019;4:143-150. DOI: 10.1302/2058-5241.4.180072.

The spatial and temporal scale of flash flood occurrence provides limited opportunities for measurements and observations using of conventional monitoring networks. These observational difficulties, often accompanied by a lack of instrumental data have turned the focus to event-based, post-disaster studies. Post-flood surveys are particularly useful, as they provide the opportunity to observe aspects of hydrological behaviour of catchments under rare runoff conditions and extreme meteorological forcing, by capitalizing on field evidence. Recently, unmanned aerial vehicles (UAVs) and the Structure for Motion (SfM) technique have been used to enhance field surveys and monitoring related to different aspects of disasters. The simple consumer-grade equipment required, its enhanced observation capabilities and certain conveniences they offer in field surveys indicate a strong potential of these technologies in many aspects of flash floods, especially given the opportunistic nature of their study. This work explores further this potential, aiming to demonstrate the application of UAVs in post-flood peak flow estimation. The research team surveyed two selected cross sections after the catastrophic 2017 flood of Mandra, developing a high resolution (2.7cm) digital surface model (DSM) using UAV imagery and the Structure from Motion technique (SfM). The detailed DSM was used to study channel geometry and flow obstructions, extract cross sections and calculate the cross sectional area and wetted perimeter. Water energy slope was defined with the use of high water marks that were placed on the DSM on the appropriate elevation. Peak discharge in the two ungauged sections were estimated at 170m3/s and 140m3/s (with a range to account for the uncertainty inherent in the dynamic nature of Manning coefficient), using the slope-conveyance method, indicating a unit peak discharge of approximately 9-10m3/s/km2. Following recommendations described in relevant literature on the integration of survey observations by means of hydrological modelling, we applied a spatially distributed hydrologic model to simulate discharge at the surveyed cross-sections (the Kinematic Local Excess Model (KLEM)) and other checks, all of which were in agreement, with the peak flow estimates provided by the UAV-aided survey analysis. The UAV allowed the collection of aerial imagery in a rapid way from an extensive area, despite that a large portion of it was inaccessible due to road closures and safety issues. In addition, detailed DSMs created using aerial imagery and the SfM technique was found to be particularly useful for studying channel geometry, obstructions and other characteristics of flow as well as for measuring cross sectional areas on demand, even at a later time, when the channel had changed due to human intervention (e.g. cleanup using heavy machinery) and water flow. These capabilities fit to the opportunistic context of studying flash flood events in the sense that UAVs can rapidly collect information within the short time frame that it is available. Nevertheless, it has to be noted that combination of ground with aerial observations is preferable.

BACKGROUND: The aim of the study was to assess the accuracy of commercially available software in estimating anterior tooth root inclination from digital impressions of the crowns of the teeth. SUBJECTS AND METHODS: Following sample size calculation and application of inclusion and exclusion criteria, 55 anterior natural teeth derived from 14 dry human skulls were selected. Impressions were taken and plaster study models were fabricated. Plaster models were scanned using the high-resolution mode of an Ortho Insight 3D laser scanner. The teeth on the digital scans were segmented and virtual roots were predicted and constructed by the Ortho Insight 3D software. The 55 natural teeth were removed from the dry skulls and scanned using the Identica extraoral white-light scanner in order to calculate their actual root angulation. The teeth were scanned twice, once to acquire the crown and the cervical part of the root, and a second time to acquire the remaining part of the root, including the apex. The two scanned segments were joined in software by superimposing them along their common part. The accuracy of the digital models generated by the Ortho Insight 3D scanner in predicting root angulation was assessed by comparing these results to the corresponding measurements of the 55 natural teeth. The long axes of the tooth models obtained from the software prediction and the scanning of the actual teeth were computed and the discrepancy between them was evaluated. The error of the methods was evaluated by repeating the measurements on 14 teeth and showed an acceptable range. RESULTS: The predicted tooth angulation was found to differ significantly from the actual angulation, both statistically and clinically. The angle between the predicted and actual long axes ranged from 2.0 to 37.6°(average 9.7°; median 7.4°). No statistically significant difference was found between tooth categories. CONCLUSIONS: Further investigations and improvements of the software are needed before it can be considered clinically effective.

The Small Magellanic Cloud (SMC) presents us with a unique opportunity to study in detail the effect of environmental processes (interaction with the LMC and the Milky Way) on its star formation history. With the 6.5m Magellan Telescope at the Las Campanas Observatory in Chile we have acquired deep B and I images in four 0.44 degree fields covering a large part of the main body of the SMC, yielding accurate photometry for 1,068,893 stars down to ~24th magnitude, with a spatial resolution of 0.201 arcsec/pixel. Colour-magnitude diagrams and luminosity functions (corrected for completeness) have been constructed, yielding significant new results that indicate at least two discrete star formation events around 2.7 and 4-5 Gyr ago.

Sea level indicators, such as tidal notches and beachrocks, may provide valuable information for the relative sea level (RSL) changes of an area. The study area, Okinawa, belongs to the Ryukyu Islands, Japan (Pacific Ocean), forming the emerged part of an active island arc, where the Philippine Sea plate is subducting beneath the Asian continent. Evidence of emergence has been noted by various studies. Beachrocks have also been studied, however, detailed examinations of their spatial extent and cement characteristics has not been accomplished. The purpose of this study is to discuss the RSL evolution in Okinawa through the re-evaluation of reported sea level indicators, with additional observations of beachrocks and notches and RSL predictions. Our findings suggest that the majority of Okinawa beachrocks have formed in the intertidal zone. Although the vertical uncertainty of the produced SLIPs is relatively large, there is a good agreement between the different types of sea level indicators. Comparisons with RSL predictions as well as the presence of uplifted notches further suggest that Okinawa island is generally characterized by an uplift trend, which is larger in its southern part.

The purpose of the study is the determination of the shoreline changes and the sediment processes along the beach of Marathon Bay, which is located at northeast Attica. In the wider on shore area the Schinias National Park, at the northeast of the bay, the Olympic Rowing Centre, military bases, archeological sites, museums etc. are encountered. The area is also characterized by high touristic activity during summer. In the area there are specific locations and constructions endangered due to coastal retreat. A lagoon was established in the study area 3.500 years BP (Pavlopoulos et al., 2006) as it is characterized by low elevations, gentle slopes and fine sediments. A survey of the coastal and marine geomorphology was carried out by acoustic scanning of the seafloor with an echo sounder and sonar side scan topographical sections perpendicular to the shoreline along with collection and analysis of surface sediments. The quantification of long-term shoreline displacements was carried out by comparing historical and contemporary aerial photographs (1945, 1960, 1969, 1988, 1996, 2001, 2010) along with very high resolution satellite imagery (2012, 2014, 2015, 2016, 2017, 2018), not to mention the tracing of the coastline (2013) with Real Time Kinematics equipment (RTK-GNSS). The quantification of long-term shoreline displacements was made with the use of the add-on application of Digital Shoreline Analysis System (DSAS) within the GIS platform ArcMap 10.6 (Thieler et al., 2009). This was accomplished by drawing 261 transects (every 50 meters), except those neighboring anthropogenic structures, perpendicularly to the historical shorelines from a stable baseline (Tsokos et al., 2018). At each transect the rate of displacement was measured.

A growing body of evidence suggests that network-based interventions to reduce HIV transmission and/or improve HIV-related health outcomes have an important place in public health efforts to move towards 90-90-90 goals. However, the social processes involved in network-based recruitment may pose a risk to participants of increasing HIV-related stigma if network recruitment causes HIV status to be assumed, inferred, or disclosed. On the other hand, the social processes involved in network-based recruitment to HIV testing may also encourage HIV-related social support. Yet despite the relevance of these processes to both network-based interventions and to other more common interventions (e.g., partner services), there is a dearth of literature that directly examines them among participants of such interventions. Furthermore, both HIV-related stigma and social support may influence participants' willingness and ability to recruit their network members to the study. This paper examines (1) the extent to which stigma and support were experienced by participants in the Transmission Reduction Intervention Project (TRIP), a risk network-tracing intervention aimed at locating recently HIV-infected and/or undiagnosed HIV-infected people and linking them to care in Athens, Greece; Odessa, Ukraine; and Chicago, Illinois; and (2) whether stigma and support predicted participant engagement in the intervention. Overall, experiences of stigma were infrequent and experiences of support frequent, with significant variation between study sites. Experiences and perceptions of HIV-related stigma did not change significantly between baseline and six-month follow-up for the full TRIP sample, and significantly decreased during the course of the study at the Chicago site. Experiences of HIV-related support significantly increased among recently-HIV-infected participants at all sites, and among all participants at the Odessa site. Both stigma and support were found to predict participants' recruitment of network members to the study at the Athens site, and to predict participants' interviewer-rated enthusiasm for naming and recruiting their network members at both the Athens and Odessa sites. These findings suggest that network-based interventions like TRIP which aim to reduce HIV transmission likely do not increase stigma-related risks to participants, and may even encourage increased social support among network members. However, the present study is limited by its associational design and by some variation in implementation by study site. Future research should directly assess contextual differences to improve understanding of the implications of site-level variation in stigma and support for the implementation of network-based interventions, given the finding that these constructs predict participants' recruitment of network members and engagement in the intervention, and thereby could limit network-based interventions' abilities to reach those most in need of HIV testing and care.

Visible Light Communication (VLC) systems use light-emitting diode (LED) technology to provide high-capacity optical links. The advantages they offer, such as the high data rate and the low installation and operational cost, have identified them as a significant solution for modern networks. However, such systems are vulnerable to various exogenous factors, with the background sunlight noise having the greatest impact. In order to reduce the negative influence of the background noise effect, optical filters can be used. In this work, for the first time, a low-cost optical vanadium dioxide (VO2) optical filter has been designed and experimentally implemented based on the requirements of typical and realistic VLC systems in order to significantly increase their performance by reducing the transmittance of background noise. The functionality of the specific filter is investigated by means of its bit error rate (BER) performance estimation, taking into account its experimentally measured characteristics. Numerous results are provided in order to prove the significant performance enhancement of the VLC systems which, as it is shown, reaches almost six orders of magnitude in some cases, using the specific experimental optical filter. © 2019 by the authors.

The author brings out the many faces of explanation in history of science by commenting on the contributions to a Focus section of Isis on historical explanation. The essay starts by indicating several ways in which the term “explanation” is used in historiographical discourse. It then distinguishes the object of explanation from the process of explanation and points out common themes and points of contention among the thirteen contributions. It also discusses two of those points in more detail: the problems of causal explanation in history of science and the imperative of avoiding anachronism in historical interpretation. The essay concludes by suggesting a pluralist take on explaining science historically.

In this article we present an interactive toolkit for the extended vocal  performance of Attic tragic poetry in drama related to its prosodic aspects. We focus on the development of modules for the phonological articulation of the ancient text based on archeomusicological readings (related to music and language) in order to add aesthetic values to the modern performance of ancient Greek drama. These tools are based on prosodic elements (melodic, rhythmic) of the ancient text and are used to: a) detect the dynamic of the articulation, accent, pronunciation as well as the tonality/pitch of the actor’s voice (recited or sung), b) track the movements and gestures of the performer and c) combine the data which is collected by the above mentioned processes (a and b) to trigger interactive sound and speech processing during the performance in order to reintroduce the prosodic aspects of voice in ancient drama.

Coastal erosion is becoming a significant problem in Greece, Bangladesh, and globally. For the prevention and minimization of damage from coastal erosion, combinations of various structures have been used conventionally. However, most of these methods are expensive. Therefore, creating artificial beachrock using local ureolytic bacteria and the MICP (Microbially Induced Carbonate Precipitation) method can be an alternative for coastal erosion protection, as it is a sustainable and eco-friendly biological ground improvement technique. Most research on MICP has been confined to land ureolytic bacteria and limited attention has been paid to coastal ureolytic bacteria for the measurement of urease activity. Subsequently, their various environmental effects have not been investigated. Therefore, for the successful application of MICP to coastal erosion protection, the type of bacteria, bacterial cell concentration, reaction temperature, cell culture duration, carbonate precipitation trend, pH of the media that controls the activity of the urease enzyme, etc., are evaluated. In this study, the effects of temperature, pH, and culture duration, as well as the trend in carbonate precipitation of coastal ureolytic bacteria isolated from two coastal regions in Greece and Bangladesh, were evaluated. The results showed that urease activity of coastal ureolytic bacteria species relies on some environmental parameters that are very important for successful sand solidification. In future, we aim to apply these findings towards the creation of artificial beachrock in combination with a geotextile tube for coastal erosion protection in Mediterranean countries, Bangladesh, and globally, for bio-mediated soil improvement.

In recent years, traditional material for coastal erosion protection has become very expensive and not sustainable and eco-friendly for the long term. As an alternative countermeasure, this study focused on a sustainable biological ground improvement technique that can be utilized as an option for improving the mechanical and geotechnical engineering properties of soil by the microbially induced carbonate precipitation (MICP) technique considering native ureolytic bacteria. To protect coastal erosion, an innovative and sustainable strategy was proposed in this study by means of combing geotube and the MICP method. For a successful sand solidification, the urease activity, environmental factors, urease distribution, and calcite precipitation trend, among others, have been investigated using the isolated native strains. Our results revealed that urease activity of the identified strains denoted as G1 (Micrococcus sp.), G2 (Pseudoalteromonas sp.), and G3 (Virgibacillus sp.) relied on environment-specific parameters and, additionally, urease was not discharged in the culture solution but would discharge in and/or on the bacterial cell, and the fluid of the cells showed urease activity. Moreover, we successfully obtained solidified sand bearing UCS (Unconfined Compressive Strength) up to 1.8 MPa. We also proposed a novel sustainable approach for field implementation in a combination of geotube and MICP for coastal erosion protection that is cheaper, energy-saving, eco-friendly, and sustainable for Mediterranean countries, as well as for bio-mediated soil improvement.

Floods are among the most dangerous natural hazards affecting the development of an area. In Greece, many drainage basins are relatively small with steep slopes, configured by steep streams with braided main channel morphology. These systems are usually dry, but experience extreme flash flood events of low frequency, but high magnitude. Such exceptionally high runoff may be a source of significant damage to human infrastructure. Despite the importance of these floods, the hydrological analysis of ephemeral streams in Greece has been especially difficult due to the lack of discharge gauges.The aim of this study is to present a flood hazard assessment and mapping methodology for the Kerinitis River drainage basin which is located in the North Peloponnese. Additionally, the simulation of a flash flood event along the main channel of the river caused by an extreme rainfall event, similar to the storm that took place on January 11th and 12th, 1997 above the nearby catchment of Xerias River, using a surface GIS-based runoff model was attempted. The application of this modeling led to the direct runoff hydrograph along the Kerinitis main channel at the outlet of the basin (the apex of the fan-delta). The proposed methodologies are based on the application of GIS with the integration of various data concerning the study area.

The last decade Greece is undergoing a multi-crisis. During this period of time the history and the past emerged in a peculiar way: the past was used as an example to be followed, while the demonstrators were calling people for disobedience and resistance against the imposed monetary and fiscal measures and against the state as well. This projection of the past to the present was entrenched on certain historical facts which are questionable and not overall well accepted, such as the 1945-9 Civil war, or the 1973 students’ uprising against the military dictatorship. Under these circumstances one could be reasonably wondering about the uses of history and the ways history is perceived as a means that construct identities. The notion of the ‟resistance cultureˮ is emerged through the utilization of history and the school history’s null curriculum, revealing the role various forms of historical narratives can play in the process of historical awareness.

We study the frequency content of an extra carrier oscillation along B-DNA aperiodic and periodic polymers and oligomers made of N monomers. In our work, we employ two variants of the Tight-Binding (TB) approach: a wire model and an extended ladder model including diagonal hoppings, as well as Real-Time Time-Dependent Density Functional Theory (RT-TDDFT). In the wire model, the site is a monomer, i.e., a base pair, while, in the extended ladder model, the site is a base. Initially, we focus on the Fourier Spectra of the probabilities to find the extra carrier at each monomer, having placed it at time zero at a specific monomer. We define the weighted mean frequency (WMF) of each site, a measure of its frequency content, using as weight the Fourier amplitude of each component of its frequency spectrum. The large-N limits of the WMFs are constants in the THz domain. To obtain a measure of the overall frequency content of carrier oscillations in the polymer, we define the total weighted mean frequency (TWMF), averaging the WMFs of all sites weighting over the mean over time probabilities of finding the extra carrier at each site. The large-N limit of the TWMFs are also constants in the THz domain. Generally, the frequency content of coherent carrier oscillations along B-DNA aperiodic and periodic polymers is in the THz domain.

Objective. This study sought to identify processes linking daily parental need experiences to daily parenting, focusing on the intervening role of parental psychological availability and stress. Design. In total, 206 mothers (Mage = 40.33 years) and 206 fathers (Mage = 42.36 years) and their elementary school child (Mage = 9.93 years; 46.6% female) participated in a 7-day multi-informant diary study. Results. Parents? daily need satisfaction was related to more daily psychological availability and lower daily stress in parent-child interactions, but parental need frustration related to less daily psychological availability and more stress. Psychological availability and stress were related to more daily parent-reported and child-perceived autonomy support and psychological control, respectively. However, parental need-based experiences were related to children?s reported parenting only indirectly (i.e., through psychological availability and stress). These associations were obtained at the within-day level but not in models predicting parenting the next day. Conclusion. Parental need-based experiences are a critical resource for parenting.

Recent theoretical and practical advances have led to the emergence of review-based recommender systems, where user preference data is encoded in at least two dimensions; the traditional rating scores in a predefined discrete scale and the user-generated reviews in the form of free-text. The main contribution of this work is the presentation of a new technique of incorporating those reviews into collaborative filtering matrix factorization algorithms. The text of each review, of arbitrary length, is mapped to a continuous feature space of fixed length, using neural language models and more specifically, the Paragraph Vector model. Subsequently, the resulting feature vectors (the neural embeddings) are used in combination with the rating scores in a hybrid probabilistic matrix factorization algorithm, based on maximum a-posteriori estimation. The proposed methodology is then compared to three other similar approaches on six datasets in order to assess its performance. The obtained results demonstrate that the new formulation outperforms the other systems on a set of two metrics, thereby indicating the robustness of the idea.

Archaeobotany is used to discover details on local land uses in prehistoric settlements developed during the middle and beginning of late Holocene. Six archaeological sites from four countries (Spain, Italy, Greece, and Turkey) have pollen and charcoal records showing clear signs of the agrarian systems that had developed in the Mediterranean basin during different cultural phases, from pre-Neolithic to Recent Bronze Age. A selected list of pollen taxa and sums, including cultivated trees, other woody species, crops and annual or perennial synanthropic plants are analysed for land use reconstructions. In general, cultivation has a lower image in palynology than forestry, and past land uses became visible when oakwoods were affected by human activities. On-site palynology allows us to recognise the first influence of humans even before it can be recognised in off-site sequences, and off-site sequences can allow us to determine the area of influence of a site. Neolithic and Bronze Age archaeological sites show similar land use dynamics implying oak exploitation, causing local deforestation, and cultivation of cereal fields in the area or around the site. Although a substantial difference makes the Neolithic influence quite distant from the Bronze Age impact, mixed systems of land exploitation emerged everywhere. Multiple land use activities exist (multifunctional landscapes) at the same time within the area of influence of a site. Since the Neolithic, people have adopted a diffuse pattern of land use involving a combination of diverse activities, using trees–crops–domesticated animals. The most recurrent combination included wood exploitation, field cultivation and animal breeding. The lesson from the past is that the multifunctional land use, combining sylvo-pastoral and crop farming mixed systems, has been widely adopted for millennia, being more sustainable than the monoculture and a promising way to develop our economy.

Frontotemporal dementia (FTD) is a heterogeneous group of neurodegenerative syndromes associated with several causative and susceptibility genes. Herein, we aimed to determine the incidence of the most common causative dementia genes in a cohort of 118 unrelated Greek FTD spectrum patients. We also screened for novel possible disease-associated variants in additional 21 genes associated with FTD or amyotrophic lateral sclerosis. Pathogenic or likely pathogenic variants were identified in 16 cases (13.6%). These included repeat expansions in C9orf72 and loss-of-function GRN variants, and likely pathogenic variants in TARDBP, MAPT, and PSEN1. We also identified 14 variants of unknown significance in other rarer FTD or amyotrophic lateral sclerosis genes that require further segregation and functional analysis. Our genetic screen revealed a high genetic burden in familial Greek FTD cases (30.4%), whereas only two of the sporadic cases (3.5%) carried a likely pathogenic variant. A substantial number of familial cases still remain without an obvious causal variant, suggesting the existence of other FTD genetic causes besides those currently screened in clinical routine

Genetic testing for cancer predisposition leads to the identification of a number of variants with uncertain significance. To some extent, variants of BRCA1/2 have been classified, in contrast to variants of other genes. CHEK2 is a typical example, in which a large number of variants of unknown clinical significance were identified and still remained unclassified. Herein, the CHEK2 variant assessment was performed through an in vivo, yeast-based, functional assay. In total, 120 germline CHEK2 missense variants, distributed along the protein sequence, and two large in-frame deletions were tested, originating from genetic test results in breast cancer families, or selected from the ClinVar database. Of these, 32 missense and two in-frame deletions behaved as non-functional, 73 as functional, and 15 as semi-functional, after comparing growth rates of each strain with positive and negative controls. The majority of non-functional variants were localized in the CHK2 kinase and forkhead-associated domains. In vivo results from the non-functional variants were in agreement with in silico predictions, and, where available, with strong breast cancer family history, to a great extent. The results of the largest, to date, yeast-based assay, evaluating CHEK2 variants, can complement and assist in the classification of rare CHEK2 variants with unclear clinical significance

Being an assembly of protein machines, cells depend on adequate supply of energetic molecules for retaining their homeodynamics. Consequently, mitochondria functionality is ensured by quality control systems and mitochondrial dynamics (fusion/fission). Similarly, proteome stability is maintained by the machineries of the proteostasis network. We report here that reduced mitochondrial fusion rates in Drosophila caused developmental lethality or if induced in the adult accelerated aging. Imbalanced mitochondrial dynamics were tolerable for various periods in young flies, where they caused oxidative stress and proteome instability that mobilized Nrf2 and foxo to upregulate cytoprotective antioxidant/proteostatic modules. Consistently, proteasome inhibition or Nrf2, foxo knock down in young flies exaggerated perturbed mitochondrial dynamics toxicity. Neither Nrf2 overexpression (with concomitant proteasome activation)nor Atg8a upregulation suppressed the deregulated mitochondrial dynamics toxicity, which was mildly mitigated by antioxidants. Thus, despite extensive functional wiring of mitostatic and antioxidant/proteostatic modules, sustained loss-of mitostasis exhausts adaptation responses triggering premature aging.

PURPOSE OF REVIEW: This review aims to discuss the recent developments in the area of apolipoprotein E (apoE) mimetics and their therapeutic potential for treating cardiovascular disease, the leading cause of mortality worldwide. RECENT FINDINGS: Ongoing research efforts target the development of novel therapies that would not only reduce circulating levels of atherogenic lipoproteins, but could also increase high density lipoprotein cholesterol (HDL-C) levels and/or improve HDL function. Among them, synthetic peptides that mimic the structure of natural human apoE, a component of triglyceride-rich lipoproteins and HDL, have been designed and proven to be functionally similar to apoE. In specific, apoE mimetic peptides mediate hepatic clearance of circulating atherogenic lipoproteins, dramatically reduce plasma cholesterol, and lead to attenuation of atherosclerosis development in vivo. These peptides also exhibit pleiotropic antiatherogenic properties, such as macrophage cholesterol efflux capacity, as well as anti-inflammatory and antioxidative functions. SUMMARY: ApoE mimetics are undergoing preclinical and clinical evaluation with promising results to date that render them attractive candidates in cardiovascular disease prevention and treatment.

Context. The ESA Gaia mission provides a unique time-domain survey for more than 1.6 billion sources with G ≲ 21 mag. Aims: We showcase stellar variability in the Galactic colour-absolute magnitude diagram (CaMD). We focus on pulsating, eruptive, and cataclysmic variables, as well as on stars that exhibit variability that is due to rotation and eclipses. Methods: We describe the locations of variable star classes, variable object fractions, and typical variability amplitudes throughout the CaMD and show how variability-related changes in colour and brightness induce "motions". To do this, we use 22 months of calibrated photometric, spectro-photometric, and astrometric Gaia data of stars with a significant parallax. To ensure that a large variety of variable star classes populate the CaMD, we crossmatched Gaia sources with known variable stars. We also used the statistics and variability detection modules of the Gaia variability pipeline. Corrections for interstellar extinction are not implemented in this article. Results: Gaia enables the first investigation of Galactic variable star populations in the CaMD on a similar, if not larger, scale as was previously done in the Magellanic Clouds. Although the observed colours are not corrected for reddening, distinct regions are visible in which variable stars occur. We determine variable star fractions to within the current detection thresholds of Gaia. Finally, we report the most complete description of variability-induced motion within the CaMD to date. Conclusions: Gaia enables novel insights into variability phenomena for an unprecedented number of stars, which will benefit the understanding of stellar astrophysics. The CaMD of Galactic variable stars provides crucial information on physical origins of variability in a way that has previously only been accessible for Galactic star clusters or external galaxies. Future Gaia data releases will enable significant improvements over this preview by providing longer time series, more accurate astrometry, and additional data types (time series BP and RP spectra, RVS spectra, and radial velocities), all for much larger samples of stars. A movie associated to Fig. 11 is available at https://www.aanda.org.Data are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/623/A110.

Context. Pismis 18 is a moderately populated, intermediate-age open cluster located within the solar circle at a Galactocentric distance of about seven kpc. Few open clusters have been studied in detail in the inner disc region before the Gaia-ESO Survey. Aims: New data from the Gaia-ESO Survey allowed us to conduct an extended radial velocity membership study as well as spectroscopic metallicity and detailed chemical abundance measurements for this cluster. Methods: Gaia-ESO Survey data for 142 potential members, lying on the upper main sequence and on the red clump, yielded radial velocity measurements, which, together with proper motion measurements from the Gaia Second Data Release (Gaia DR2), were used to determine the systemic velocity of the cluster and membership of individual stars. Photometry from Gaia DR2 was used to re-determine cluster parameters based on high confidence member stars only. Cluster abundance measurements of six radial-velocity member stars with UVES high-resolution spectroscopy are presented for 23 elements. Results: The average radial velocity of 26 high confidence members is -27.5 ± 2.5 (std) km s-1 with an average proper motion of pmra = -5.65 ± 0.08 (std) mas yr-1 and pmdec = -2.29 ± 0.11 (std) mas yr-1. According to the new estimates, based on high confidence members, Pismis 18 has an age of τ = 700+40-50 Myr, interstellar reddening of E(B - V) = 0.562+0.012-0.026 mag and a de-reddened distance modulus of DM0 = 11.96+0.10-0.24 mag. The median metallicity of the cluster (using the six UVES stars) is [Fe/H] = +0.23 ± 0.05 dex, with [α/Fe] = 0.07 ± 0.13 and a slight enhancement of s- and r-neutron-capture elements. Conclusions: With the present work, we fully characterized the open cluster Pismis 18. We confirmed its present location in the inner disc. We estimated a younger age than the previous literature values and we gave, for the first time, its metallicity and its detailed abundances. Its [α/Fe] and [s-process/Fe], both slightly super-solar, are in agreement with other inner-disc open clusters observed by the Gaia-ESO survey. Full Table 2 is only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/626/A90

In this article, a rigorous analytical methodology is introduced for designing near-zero refractive index metamaterials (NZIMs). Our proposed NZIM media is realized by three stacked layers of perforated metallic surfaces, each layer composed of a fishnet-like periodic array of square holes. By a proper design of such structures, a low refractive index medium is achieved at their corresponding plasma frequency. The low refractive index property is studied by retrieving the effective parameters of NZIM via inversion techniques, which gives an effective near-zero refractive index, at an operating frequency of 1.5 GHz. Then, the designed NZIM is used for gain enhancement of a circular waveguide antenna. The analysis shows that the proposed platform can enhance the directivity of our antenna by 3 dB while maintaining the return loss <−20 dB. © 2019 Wiley Periodicals, Inc.

Genetic Algorithms (GAs) have been predominantly used in video games for finding the best possible sequence of actions that leads to a win condition. This work sets out to investigate an alternative application of GAs on action-adventure type video games. The main intuition is to encode actions depending on the state of the world of the game instead of the sequence of actions, like most of the other GA approaches do. Additionally, a methodology is being introduced which modifies a part of the agent's logic and reuses it in another game. The proposed algorithm has been implemented in the GVG-AI competition's framework and more specifically for the Zelda and Portals games. The obtained results, in terms of average score and win percentage, seem quite satisfactory and highlight the advantages of the suggested technique, especially when compared to a rolling horizon GA implementation of the aforementioned framework; firstly, the agent is efficient at various levels (different world topologies) after being trained in only one of them and secondly, the agent may be generalized to play more games of the same category.

A distinct combination of transcription factors elicits the acquisition of a specific fate and the initiation of a differentiation program. Multiciliated cells (MCCs) are a specialized type of epithelial cells that possess dozens of motile cilia on their apical surface. Defects in cilia function have been associated with ciliopathies that affect many organs, including brain and airway epithelium. Here we show that the geminin coiled-coil domain-containing protein 1 GemC1 (also known as Lynkeas) regulates the transcriptional activation of p73, a transcription factor central to multiciliogenesis. Moreover, we show that GemC1 acts in a trimeric complex with transcription factor E2F5 and tumor protein p73 (officially known as TP73), and that this complex is important for the activation of the p73 promoter. We also provide in vivo evidence that GemC1 is necessary for p73 expression in different multiciliated epithelia. We further show that GemC1 regulates multiciliogenesis through the control of chromatin organization, and the epigenetic marks/tags of p73 and Foxj1. Our results highlight novel signaling cues involved in the commitment program of MCCs across species and tissues.This article has an associated First Person interview with the first author of the paper.

The subventricular zone (SVZ) is one of two main niches where neurogenesis persists during adulthood, as it retains neural stem cells (NSCs) with self-renewal capacity and multi-lineage potency. Another critical cellular component of the niche is the population of postmitotic multiciliated ependymal cells. Both cell types are derived from radial glial cells that become specified to each lineage during embryogenesis. We show here that GemC1, encoding Geminin coiled-coil domain-containing protein 1, is associated with congenital hydrocephalus in humans and mice. Our results show that GemC1 deficiency drives cells toward a NSC phenotype, at the expense of multiciliated ependymal cell generation. The increased number of NSCs is accompanied by increased levels of proliferation and neurogenesis in the postnatal SVZ. Finally, GemC1-knockout cells display altered chromatin organization at multiple loci, further supporting a NSC identity. Together, these findings suggest that GemC1 regulates the balance between NSC generation and ependymal cell differentiation, with implications for the pathogenesis of human congenital hydrocephalus.

Physical activity, health and well-being are valued in France, where over 65% of the population practice sport (Schann, 2014). French towns provide sport clubs, athletic facilities and parks for jogging, running or cycling and most workplaces include gyms, fitness programs or sport activities. Companies like Apple have integrated gyms in the workplace; the bank Société Générale provides dance activities for employees and managers; the Valeo group-smart technology for smart cars organizes sport events resembling the Olympics. Physical activities are encouraged to improve or maintain employee health while developing-strengthening cooperation and teambuilding for both genders. In contrast, gender inequality prevails, especially in sport leadership and entrepreneurship. This study focuses on the major obstacles confronted by women entrepreneurs in France and in francophone countries. Method: In depth literature review (30 studies) on women’s entrepreneurial activities over the period 2002-2018, a topic not sufficiently studied in France, including two studies on gender inequalities in sport. Results: The leaky pipeline, a barrier to retention, along with the family/work conflict, lack of trust, funding or access to capital and limited-inadequate networking. Discussion/Conclusion: Need to eliminate gender stereotypes in France. Out of the 30 million people over 18 years of age who play sport or engage in physical activities at least once a week, almost half are women (14.5 million). On the other hand, women continue to be invisible (underrepresented) in sport leadership and entrepreneurship. They usually turn to social entrepreneurship: education, social care or health services. Future studies required to identity obstacles confronted by women entrepreneurs in France, the country of the first woman Olympic entrepreneur, Alice Milliat, who was compared to Pierre de Coubertin in 1922 for the successful organization of the "Women’s Olympic Games" in Paris on August 20, 1922, an event which attracted 20,000 spectators (Kamberidou, 2016).

This paper focuses on the socio-cultural aspects of gender integration in the Armed Forces, arguing for gender-neutral standards. It begins with a detailed literature review relevant to women’s integration in the military, subsequently focusing on Greece, and in the final analysis arguing that coed military sport participation and exercises serve as a means of bridging the gender-divide and eliminating gender harassment. Though coed sport (mixed-gender teams) as a tool for women’s inclusion and integration in the military seems to be part of the solution, it is a topic on which research is scarce (Kefi Chatzichamperi, 2018, 2019). This study does not examine physiologic attributes: biological and anatomical differences or research on sex hormones and how they affect the nervous system and physical strength, and subsequently soldier performance (Tenan, 2017). Using a qualitative theoretical approach, it discusses the social dimensions of evidence-based research on why and how gender integration is relevant. It includes current and ongoing studies presented at the 14th Conference of the European Research Group on Military and Society (ERGOMAS), hosted by the Hellenic Army Academy in Athens, indicating that a main challenge in the military today is to ensure a gender balance through women’s inclusion, active engagement and retention. Research emphasizes the need for change in the military culture on all levels—legal and organizational—including gender-awareness and diversity training, especially on the complimentary skills that both genders bring to the table as opposed to the "wastage of talent" (Kamberidou, 2013). Certainly, establishing gender-neutral standards to eliminate sexism, and promote inclusion and integration is a complex and multifaceted process, the reason researchers in the social sciences use a variety of theoretical approaches (Patsantaras, 2015, 2013; Seagrave, 2016). The results indicate that the gender participation gap continues in all current military organizations: Hungary holding the highest female participation rate (19.3%) and Turkey the lowest (0.8%).   Keywords: Degendering, gender/sex distinction, gender harassment, armed forces, homophobia, sexual and gender-based violence (SGBV), mixed-gender sports  

BACKGROUND: Skin cancer represents the most common human malignancy, and it includes BCC, SCC, and melanoma. Since melanoma is one of the most aggressive types of cancer, we have herein attempted to develop a gene-specific intron retention signature that can distinguish BCC and SCC from melanoma biopsy tumors. METHODS: Intron retention events were examined through RT-sqPCR protocols, using total RNA preparations derived from BCC, SCC, and melanoma Greek biopsy specimens. Intron-hosted miRNA species and their target transcripts were predicted via the miRbase and miRDB bioinformatics platforms, respectively. Iotantronic ORFs were recognized through the ORF Finder application. Generation and visualization of protein interactomes were achieved by the IntAct and Cytoscape softwares, while tertiary protein structures were produced by using the I-TASSER online server. RESULTS: c-MYC and Sestrin-1 genes proved to undergo intron retention specifically in melanoma. Interaction maps of proteins encoded by genes being potentially targeted by retained intron-accommodated miRNAs were generated and SRPX2 was additionally delivered to our melanoma-specific signature. Novel ORFs were identified in MCT4 and Sestrin-1 introns, with potentially critical roles in melanoma development. CONCLUSIONS: The property of c-MYC, Sestrin-1, and SRPX2 genes to retain specific introns could be clinically used to molecularly differentiate non-melanoma from melanoma tumors.

Akrotiri Salt Lake is located 5km west of the city of Lemesos, in the southern-most part of the island of Cyprus. The palaeogeographic evolution of the Akrotiri Salt Lake presents a great scientific interest, especially during the Holocene where the eustatic movements combined with local active tectonics and climate changes have developed a unique geomorphological environment. The Salt Lake, today a closed lagoon, which is depicted in Venetian maps (Bordon AD 1528) as being connected to the sea, can provide evidence of the geological settings and landscape evolution of the area. In this study, we investigate the development of Akrotiri Salt Lake through a series of cores which penetrated the Holocene sediment sequence. Sedimentological, micropaleontological (benthic foraminifera and ostracods) analyses and geochronological studies performed on deposited sediments, identifying the complexity of the evolution of the Salt Lake and the progressive change of the area from maritime space to an open bay and finally to a closed Salt Lake.

Akrotiri Salt Lake is located 5km west of the city of Lemesos, in the southern-most part of the island of Cyprus. The palaeogeographic evolution of the Akrotiri Salt Lake presents a great scientific interest, especially during the Holocene where the eustatic movements combined with local active tectonics and climate changes have developed a unique geomorphological environment. The Salt Lake, today a closed lagoon, which is depicted in Venetian maps (Bordon AD 1528) as being connected to the sea, can provide evidence of the geological settings and landscape evolution of the area. In this study, we investigate the development of Akrotiri Salt Lake through a series of cores which penetrated the Holocene sediment sequence. Sedimentological, micropaleontological (benthic foraminifera and ostracods) analyses and geochronological studies performed on deposited sediments, identifying the complexity of the evolution of the Salt Lake and the progressive change of the area from maritime space to an open bay and finally to a closed Salt Lake.

Three main aquifer systems developed on Kythira Island include (Pagounis, 1981; Pagounis & Gertsos, 1984, Danamos, 1991; Koumantakis et al., 2006):

• The porous aquifer system in Neogene and Quaternary formations.
• The karstic aquifer system in the carbonate formations of the Pindos and Tripolis units.
• The aquifer system (both shallow and deep) in the fractured hard rocks mainly of the Phyllites – Quartzites unit.

The main discharge of the aquifer systems takes place in coastal and submarine brackish springs around the island, except for its northern part where the Phyllites – Quartzites unit outcrops and its central part where springs of small capacity discharge the carbonate formations of the Pindos unit. The municipal water supply of Kythira has been reinforced by a series of projects and interventions, focusing on the summer touristic period, when water demand surpasses by far water availability, mainly consisting of new deep boreholes. Precipitation is the direct recharge of the three aforementioned aquifer systems while indirectly lateral discharge occurs in places between adjacent and tangential aquifer systems and from the streams runoff as well. On August 4, 2017 a shrub, rather a forest fire broke out close to the island hospital; it expanded rapidly due to strong winds blowing in the area and raged out of control for four days, inducing considerable damage. The size of the fire-affected area was about 20km2, 16km2 mainly of shrub and 4km2 of agriculture land. For the detailed evaluation of the geo-environmental impact of the aforementioned fire to the aquifer systems of the Kythira Island concerning the quantitative and qualitative degradation seventeen municipal water points were finally selected for further hydrogeological study. The water points monitoring network were used in September 2017, June 2018 and October 2018 for measurements of the water tables heads and springs discharges while water samples were collected and chemical, trace elements and microbiological analysis were carried out. The impact of the fire on the quantity of the aquifer systems of the wider fire-affected area could not be fully clarified and there was indirect evidence of their recharge (it remains unknown its rate compared to the recharge before the August 2017 fire) during the three field trips such as:

• Fluctuation of the measurements of the water table heads.
• Fluctuation of the measurements of springs discharges.
• Fluctuation of the measurements of boreholes hydrometers.
• Changes to the hydrochemical facies of the Piper’s, Durov’s and Stiff’s diagrams of the collected water samples.

The results and the evaluation of the chemical and trace elements showed that there was no impact of the fire on the quality of the wider fire-affected area aquifer systems. However, microbiological analysis from the Mylopotamos spring showed qualitative degradation, due to human activities in the wider area preexisting the August 2017 fire (Pagounis, 1981). For the sustainable water resources management of the wider fire-affected area new projects were proposed in order to prevent phenomena that favors the runoff instead of infiltration which lead to the restriction of the recharge of the three main aquifer systems, such as works of artificial recharge.

Mediterranean temporary ponds (MTPs) constitute priority habitats under the European Union Habitats Directive, inhabited by several rare endemic species and subjected to unstable environmental conditions. Lakes and pond act as early indicators of climate change, in which alpine ecosystems are especially vulnerable. The study area is located in a mountainous Natura 2000 site of Central Greece, designated as “National Forest Park of Mt Oiti” (Ethnikos Drymos Oitis), which hosts a number of MTPs. Field sampling of soil and water carried out in four MTPs during dry and wet periods between 2012 and 2014. Electrical Resistivity Tomography (ERT) technique was used for the delineation of the subsurface geological structure. This study aims to present the current ecological status of Mt Oiti MTPs with respect to their geo-environmental characteristics, emphasizing to their indirect correlation with plant species richness. Moreover, this paper aims to address the lack of basic ecological background on MPTs network of Mt Oiti concerning their characteristics along with the pressures received from various activities. MTPs of Mt Oiti were classified according to their ecological status, by identifying the habitats’ threats and defining their geological structure, mineralogy and physiochemical parameters of each pond.

The Stypsi Cu-Mo-Au-Re prospect, Lesvos island, is a shallow porphyry-epithermal system hosted within a middle Miocene microgranite porphyry, which was emplaced along NNE-, NW- and NE-trending structures, within trachyandesites to trachydacites and felsic pyroclastics of the Stypsi caldera. The mineralization comprises three stages: Stage I is characterized by magnetite-actinolite ± quartz in transitional and banded quartz veins mostly developed within the microgranite and the surrounding lavas related to calcic-potassic and propylitic alteration of the host rocks. In the banded veins, quartz is botryoidal, suggesting crystallization from a gel. Abundant vapor-rich inclusions in the bands produce a dark grey to black color. Within the veins, magnetite, chalcopyrite, bornite and native gold were followed in time by pyrite, hematite, sphalerite and galena. Stage I mineralization was synchronous and also postdates quartz formation in the veins, since it crosscuts and/or fills vugs in the center of the veins. Sulfides are associated with various combinations of K-feldspar, actinolite, epidote, chlorite, and calcite gangue minerals. Pyrite-molybdenite-chalcopyrite (Stage II) and late intermediate sulfidation epithermal veins (Stage III) overprint earlier mineralization and alteration, and are associated with sericite-calcite and sericite-kaolinite alteration of the porphyry system and spatially associated lavas, respectively. Molybdenite is widespread in the first two mineralization stages, with Re content ranging from about 0.3 wt% in Stage I to 1.96 wt% in Stage II. A barren silicic and advanced argillic (alunite-kaolinite) lithocap, is exposed on top of the porphyry-style mineralization and is crosscut by non-mineralized high-sulfidation epithermal chalcedony-barite veins. Bulk ore analyses of surface samples from the Stypsi prospect yielded values of up to 276 ppm Mo, 978 ppm Cu, up to 0.5 g/t Au, up to 3 g/t Ag, and up to 70 ppb Pd and Re. Fluid inclusion data indicate that the Stage I transitional and banded quartz veins were deposited at 420 °C–530 °C and at pressures up to 450 bars, from boiling hydrothermal fluids. The fluid in the veins consists of a brine (40–61 wt% NaCl equiv) that coexists with a lower salinity (6–14 wt% NaCl equiv) liquid phase and a low-density vapor-rich fluid. Fluid inclusions in quartz of the Stage III intermediate-sulfidation epithermal veins are characterized by relatively low homogenization temperatures (231 °C–288 °C) and salinities (up to 1.9 wt% NaCl equiv), which was the result of subsequent dilution of the moderately saline fluids by circulating meteoric water. This study verifies earlier works suggesting that Au-enriched felsic magmas are able to crystallize Re-rich molybdenite, and that Re may also be redistributed and enriched in later stages during the deposition of porphyry-style mineralization. The Stypsi prospect ressembles in many respects (e.g., Au grades, Cu/Mo ratios, the Re content of molybdenite and the presence of ore-grade calcic-potassic alteration), other porphyry Cu-Mo-Re-Au systems hosted in calc-alkaline rocks in northeastern Aegean, Greece.

OBJECTIVES: To evaluate the hard tissue and facial profile changes in matched extraction and non-extraction Class I patients by the use of geometric morphometrics. SUBJECTS AND METHODS: From a parent sample of 542 Class I patients, previously subjected to discriminant analysis, a subsample of 68 borderline cases was obtained, 34 treated with extraction and 34 without extraction of 4 first premolars. Geometric morphometric methods (Procrustes superimposition and Principal Component Analysis) were applied on cephalometric tracings to assess the validity of the discriminant analysis in successfully identifying a morphologically homogeneous group and to evaluate inter- and intra-group skeletal and facial profile shape changes. RESULTS: No significant pre-treatment shape difference between the two groups was found, thus validating the discriminant analysis. The non-extraction group showed increase in hard tissue facial height (P < 0.001), with slight lower lip retrusion and upper lip protrusion (P = 0.027). The extraction group showed retraction of the hard tissue and facial profile outline (P < 0.001). Permutation tests for post-treatment inter-group differences resulted in P = 0.054 for the soft tissue outline and P = 0.078 for the hard tissue skeletal component. CONCLUSIONS: The evidence indicates that borderline cases treated with four premolar extractions will exhibit lip retrusion compared to non-extraction treatment.

Platis Gialos Bay located at the Southern part of Sifnos Isl. and his length is determined at 1.000 m, with SE direction. The coast of Platis Gialos Sifnos has been under erosion and permanent coastal retreat for several years, especially at the central and west part of the beach. The main causes of coastal erosion are anthropogenic.This paper focuses most intently on the geomorphological and sedimentological dynamic processes of the Bay which forming the current situation. For this reason a number of tasks took place in order to determine the level of disturbances of this dynamic equilibrium. This study included two phases of survey for two different periods (summer/winter). The first phase deals with the geomorphological and sedimentological coast characteristics, and includes: i) long-term geomorphological evolution of the coastal zone through the analysis of satellite images (Google Earth), in order to estimate the intensity of coastal erosion. ii) topographic sections at the surface of the coastal zone, through D-GPS (Spectra Precision SP80 GNSS Receiver), perpendicular to the coastline, iii) sediment sampling in the subaerial coastal area, iv) analytical recording and mapping of the summer and winter shorelines via the D-GPS, v) the situation of the potential feeders of the shore with materials, necessary for the formation of an alluvial beach, and vi) recording of land uses (Fig.1). The second phase, includes the geomorphological and sedimentological characteristics of the marine area, in particular: i) topographic sections of the bottom surface until the depth of 1.5 m, through D-GPS, perpendicular to the coastline ii)sediment sampling in the subaquatic marine area, iii) data of the numerical recomposition of the wind and wave conditions of the study area, iv) bathymetric eco-sonar data (Lowrance LCX-15MT), v) side-scan single beam eco-sounder (StarFish 450), to determine the seabed morphological features of the bay and, vi) substrate component mapping (Fig. 1). Laboratory analyzes were followed by the methods of dry granulometry, in order to categorize it, in different types on the basis of Folk & Ward (1957) method through GRATISTAT (v.8) software.

Many researchers have presented that ground penetrating radar (GPR) is a subsurface survey method indicated to acquire important preliminary information in various geological subsurface investigations, but also in archaeological and cultural heritage studies (Conyers, 2016). GPR stands out among the geophysical methods applied in archaeology, given the fact that it is a non-destructive practical field technique. GPR results can be presented as bi-dimensional profiles (2D) and three-dimension images (3D), in the form of block diagrams, fence-diagrams and volume/depth-slices. Especially the amplitude maps (e.g., depth-slices maps) allow the identification of areas with high or low amplitude of specific deep reflectors. Therefore, they can be used to identify buried targets and their dimensions, allowing the reconstruction of the subsurface in 3D (Porsani et al., 2010).

Many researchers have presented that ground penetrating radar (GPR) is a subsurface survey method indicated to acquire important preliminary information in various geological subsurface investigations, but also in archaeological and cultural heritage studies (Conyers, 2016). GPR stands out among the geophysical methods applied in archaeology, given the fact that it is a non-destructive practical field technique. GPR results can be presented as bi-dimensional profiles (2D) and three-dimension images (3D), in the form of block diagrams, fence-diagrams and volume/depth-slices. Especially the amplitude maps (e.g., depth-slices maps) allow the identification of areas with high or low amplitude of specific deep reflectors. Therefore, they can be used to identify buried targets and their dimensions, allowing the reconstruction of the subsurface in 3D (Porsani et al., 2010).

The disastrous phenomenon of aseismic ground fissures along the eastern Thessaly basin has deteriorated since 1989. The main reason for these fissures is the over-pumping, which leads to differential vertical compaction of the aquifer system and subsidence on the land surface. In this paper, we present the results of a combined geophysical survey applied in the area (VES and TEM soundings), in order to investigate the subsurface geological conditions. The geological regime of the area is comprised of the alpine basement, transgression formations and finally a package of post-alpine deposits with respectful thickness. A peudo-3D representation of resistivity maps for several depths of investigation was produced. Additionally, a dataset of deep boreholes was used for the calibration of the geophysical data. All the borehole and sounding interpreted data were grouped into three categories in order to produce the Lithology Model of the area. The alpine bedrock was adumbrated only at the southeast and central part of the basin, where we do not observe ground fissures. The absence of alpine bedrock for depths up to 300 meters, the thick and coarse-grained deposits and finally the over-pumping seem to contribute to the creation of the ground fissures.

The disastrous phenomenon of aseismic ground fissures along the eastern Thessaly basin has deteriorated since 1989. The main reason for these fissures is the over-pumping, which leads to differential vertical compaction of the aquifer system and subsidence on the land surface. In this paper, we present the results of a combined geophysical survey applied in the area (VES and TEM soundings), in order to investigate the subsurface geological conditions. The geological regime of the area is comprised of the alpine basement, transgression formations and finally a package of post-alpine deposits with respectful thickness. A peudo-3D representation of resistivity maps for several depths of investigation was produced. Additionally, a dataset of deep boreholes was used for the calibration of the geophysical data. All the borehole and sounding interpreted data were grouped into three categories in order to produce the Lithology Model of the area. The alpine bedrock was adumbrated only at the southeast and central part of the basin, where we do not observe ground fissures. The absence of alpine bedrock for depths up to 300 meters, the thick and coarse-grained deposits and finally the over-pumping seem to contribute to the creation of the ground fissures.

In June 2018 a geophysical campaign begun from the Department of Geology and Geoenvironment at the departmental excavation of Plasi Marathon. The geophysical survey focused on the northern part of the area, where the first excavation trenches of 2017 and 2018 revealed architectural remains of the late Classical and Hellenistic period. The main aim of the research was the investigation of the existence and spatial extent of the architectural remains in the unexcavated parts. Taking into consideration the revealed remains of the excavated parts and the geoenvironmental conditions of the area, the geoelectromagnetic method of Ground Penetrating Radar (GPR) and the high resolution geoelectrical tomography (ERT) technique, were selected to be applied. Simultaneously, a topographic ‘reference base’ was established in the area in order to record the location of the geophysical measurements with real-time dGPS measurements. From the combinational evaluation of the processed geophysical data, we adumbrate the areas of possible archaeological ‘targets’, covered with post-alpine river deposits. Future excavation trenches at the indicated areas will confirm the existence or not of the covered architectural remains.

Hepatitis B virus (HBV) and hepatitis C virus (HCV) affect more than 320 million people worldwide, which is more than HIV, tuberculosis (TB) and malaria combined. Elimination of HBV and HCV will, therefore, produce substantial public health and economic benefits and, most importantly, the prevention of 1.2 million deaths per year. In 2016, member states of the World Health Assembly unanimously adopted a resolution declaring that viral hepatitis should be eliminated by 2030. Currently, few countries have elimination programmes in place and even though the tools to achieve elimination are available, the right resources, commitments and allocations are lacking. During the fifth International Viral Hepatitis Elimination Meeting (IVHEM), 7-8 December 2018, Amsterdam, the Netherlands, an expert panel of clinicians, virologists and public health specialists discussed the current status of viral hepatitis elimination programmes across multiple countries, challenges in achieving elimination and the core indicators for monitoring progress, approaches that have failed and successful elimination plans.

Chronic hepatitis B virus (HBV) infection is a global public health challenge on the same scale as tuberculosis, HIV, and malaria. The International Coalition to Eliminate HBV (ICE-HBV) is a coalition of experts dedicated to accelerating the discovery of a cure for chronic hepatitis B. Following extensive consultation with more than 50 scientists from across the globe, as well as key stakeholders including people affected by HBV, we have identified gaps in our current knowledge and new strategies and tools that are required to achieve HBV cure. We believe that research must focus on the discovery of interventional strategies that will permanently reduce the number of productively infected cells or permanently silence the covalently closed circular DNA in those cells, and that will stimulate HBV-specific host immune responses which mimic spontaneous resolution of HBV infection. There is also a pressing need for the establishment of repositories of standardised HBV reagents and protocols that can be accessed by all HBV researchers throughout the world. The HBV cure research agenda outlined in this position paper will contribute markedly to the goal of eliminating HBV infection worldwide.

Nonalcoholic beverages such as juices and juice beverages, soft drinks, energy drinks, milk, and soy beverages provide a variety of health benefits. Many of them contain water-soluble nutrients, which consist of great resources of antioxidants, minerals, and vitamins. The consumption of these products comprises a significant part of the daily diet as from freshly squeezed juice to processed fortified beverages. One of the most important nutrients of these beverages are vitamins either fat-soluble (A, D) or water-soluble (B-complex, C) that are essential for human life and for normal body function. Nowadays, the food industry is interested in nutritionally rich foods and beverages with vitamins in order to replace the losses during storage and processing or to enable a nutritional label claim on the product. At the same time, consumers choose fresh, fortified beverages enhancing their diet and their health. This chapter is an effort to classify the vitamins in fresh and processed nonalcoholic beverages and their nutritional importance. Several analytical methodologies for their determination in different food matrices (fruits, vegetables, and their products), mainly chromatographic methods, are presented. Because of their instability, it is necessary to focus on the extraction procedure that will not cause their degradation.

In these days, the agro-food economy is focused on the consumer demands regarding safety, quality, and security of food. Traceability of wine can be defined as a method through which anybody in the wine supply chain can be able to verify the origin and composition of wines and its conditions of storage. Traceability ensures the registration on specific documents of all manipulations of basic materials, ingredients, and final products. They are created to allow a rapid identification of the product history. The wine supply chain requires traceability from grape production to processing and wine distribution. Authenticity of wine has been extensively examined as wine is an easily adulterated product because it has high alcohol content and low pH and also is available worldwide. Responsible and continuous controls are required to maintain the quality of wine. Usually volatile compounds are used to characterize varieties, whereas minerals are used for geographical differentiation. Amino acids as well as phenolic compounds evaluation are used for both. The growth of advanced techniques for wines authentication is a challenge, which currently is given a special focus. Wine adulteration for both variety and origin has been very extensive. Therefore, apart from novel experimental techniques (gas chromatography-mass spectrometry, inductively coupled plasma MS, 13C nuclear magnetic resonance, Fourier transform infrared and DNA, and among others), it is also used as multivariate analysis comprising principal component analysis, discriminant analysis, canonical analysis, and cluster analysis.

Stage of lactation (SOL) is a major factor affecting several characteristics of milk such as fatty acids content and composition, protein and main minerals content. These variations may have important quantitative and qualitative consequences on the characteristics of cheese. The aim objective of this study was to analyse the effect of lactation stage on the fat and fatty acids composition of the artisanal camembert type-cheese made from cow’s milk collected in Mostaganem region (Algeria) and provided from three stages of lactation (early, mid and late). In this study and for each stage of lactation, the fat and fatty acid composition of camembert type-cheese were analysedand evaluated. Results showed that the total lipids were related to the stageof lactation (p<0.05), ranging from 14.6% for the 3rd SOL to 23% for the 1stSOL. The fatty acids composition of Camembert-type cheese showed a highpolyunsaturated fatty acids percentage dominated by ω6 and ω3 fatty acidsrepresented by linoleic and α-linolenic acids. Indeed, they recorded maximum values of 2.53% and 0.6% respectively, for the Camembert made withthe milk of the 1st SOL (p<0.05). Concerning monounsaturated fatty acidsclass, oleic acid is found to be the most important fatty acid with a maximumpercentage (26.1%) in Camembert of the 1st SOL (p<0.05). Finally, this studyconcluded that the stage of lactation plays a determining role on the biochemical composition of the camembert type-cheese, particularly on lipidsand essential fatty acids.

Mediterranean Temporary Ponds (MTPs) are shallow water bodies which are characterized from a short wet period and their small size (Zacharias et al., 2007). MTPs of Europe have are under an effective protection status, as a result of their identification as a priority habitat (Annex I code 3170*) in the EU Directive 92/43/EEC (Habitats' Directive). These ponds are very delicate ecosystems regarding their hydrological and geochemical characteristics. Due to their small size, they are open to random destruction or other unpredictable dangers. Although small in size, MTPs are complex ecosystems where topography, soil, water and hydrological conditions and microorganisms are closely connected (Zacharias et al., 2007; Stamatakis et al., 2015). The conservation and restoration of such ecosystems is very difficult because of their unique characteristics. The most common threats for MTPs include destruction of the hosting area through human and animal pressures, hydrological disturbance, fire and generally changes in ecological conditions resulting in an increase of competitive plants, nutrition influx, toxic contaminants and wastes, sedimentary deposit filling, exotic-invasive fauna and flora and negative effects from domesticated or hunted fauna (Dimitriou et al., 2006).

Hepatitis C virus (HCV) genotype and subtype distribution differs according to geographic origin and transmission risk category. Previous molecular epidemiology studies suggest the presence of multiple subtypes among Cypriot subjects. To investigate HCV genotype- and subtype-specific dissemination patterns, origins, and transmission in Cyprus, we analyzed HCV sequences encoding partial Core-E1 and NS5B regions. Analyzed populations comprised the general population and high-risk cohorts in Cyprus and a globally sampled dataset. Maximum-likelihood phylogeny reconstruction with bootstrap evaluation, character reconstruction using parsimony, and bootstrap trees estimated by ML were performed to identify the geographic origin of HCV subtypes and statistically significant dispersal pathways among geographic regions. Phylogeographic analyses traced the origin of subtypes in the general population and among PWID in Cyprus to unique and overlapping globally distributed regions. Phylogenetic analysis in Core-E1 revealed that most sequences from incarcerated populations in Cyprus clustered with the general population and PWID. We estimate that HCV infections in Cyprus originate from multiple global sources while most HCV transmissions among incarcerated individuals occur locally. This analysis is one of a few studies tracing HCV dispersal patterns using global datasets, and these practices and findings should inform how HCV epidemics are targeted by future prevention policies.

BACKGROUND: Population movements have been increasing over the past years in Europe due to socioeconomic factors, global turbulence and conflicts, especially in the area of Middle East. The presence of migrant populations in Europe challenges health systems due to increased requirements for health care provision. However, to date there is limited published data on the burden of disease among this population (in Greece and elsewhere). Our objective was to record burden of disease of undocumented migrants hosted in a Detention Center and therefore generate data for migrant and public health planning. METHODS: Epidemiological data have been collected for 4756 male migrants hosted in a Detention Center from mid 2013 to mid 2015. Of them, 1427 have used health services in the Center, which maintained a detailed record of their medical history and tests. RESULTS: The majority of the study population was aged between 18 and 40 years old. Among those who used health services, most suffered from respiratory (45.6%) and digestive (30.1%) diseases. Injury, poisoning and other external causes accounted for 19.6% of service use, diseases of the skin and subcutaneous tissue for 18.7%, and factors affecting health status and contact with health services for 16.7%. Prevalence of communicable diseases was 15.9% amongst migrants randomly tested. CONCLUSION: Systematic screening and monitoring of diseases and use of health services by migrants in detention centers allows for an evidence based understanding of the burden of disease related to these populations and the investment required to effectively manage it, thus providing critical input to appropriate health planning. Surveillance for communicable diseases amongst migrants in detention centers would also allow for a true picture of the impact of their presence on public health indicators and help address related prejudices and stigma.

This study examines the conditional correlation and the resulting optimal hedge ratios between the Credit Default Swap (CDS) spreads of the U.S. metal and mining industries, and the prices of copper, platinum, silver and gold using the daily date from December 14, 2007 to August 18, 2018. It compares volatility and conditional correlation of the CDSs and the metal prices by employing multivariate GARCH family models which capture distinct characteristics of financial time series. It utilizes rolling window estimation techniques and constructs the one-step-ahead out-of-sample forecasts for the dynamic conditional correlations and thereafter the optimal hedge ratios. In general, our results show that copper provides the best possible hedge for dealing with the U.S. metals and mining industries’ credit risks. Our results are robust under alternate model specifications, choice of model refits and distributional assumptions.

People who inject drugs (PWID) comprise one of the major transmission risk groups for human immunodeficiency virus (HIV) and hepatitis C virus (HCV). In 2011, Athens experienced a large HIV outbreak among PWID. Significant public health interventions were implemented in response to the HIV outbreak. The aims of this study were to estimate the indirect effects of the HIV interventions on HCV infection and to evaluate the concept of the association between HCV and HIV infections in the case of Athens. A dynamic, stochastic, individual-based model was developed to simulate HCV transmission among PWID. We calibrated the model to reproduce the observed HCV prevalence among PWID in Greece. Two years prior to the HIV outbreak, an undetected HCV outbreak has occurred. In 2009, the incidence of HCV infection increased from 640 (495, 842) cases in 2008 to 1260 (1060, 1500). The mean time from initiation of injecting drug use to HCV acquisition decreased from 29 months in 2008 to 13 months in 2009. After HIV interventions, HCV incidence declined by 64.8% in 2012, compared to 2009. The averted HCV incidence cases attributed to the HIV-implemented interventions were 2200 (1950, 2480), during 2012-2015. The cumulative number incident HCV cases in Athens during 2002-2015 was about 9900 (7800, 12 100). Our results highlight that before the 2011 HIV outbreak in Athens, an HCV outbreak occurred in 2009. Prevention measures for HIV that took place in the Athens metropolitan area in 2012 reduced significantly the incidence of HCV.

People who inject drugs (PWID) comprise one of the major transmission risk groups for human immunodeficiency virus (HIV) and hepatitis C virus (HCV). In 2011, Athens experienced a large HIV outbreak among PWID. Significant public health interventions were implemented in response to the HIV outbreak. The aims of this study were to estimate the indirect effects of the HIV interventions on HCV infection and to evaluate the concept of the association between HCV and HIV infections in the case of Athens. A dynamic, stochastic, individual-based model was developed to simulate HCV transmission among PWID. We calibrated the model to reproduce the observed HCV prevalence among PWID in Greece. Two years prior to the HIV outbreak, an undetected HCV outbreak has occurred. In 2009, the incidence of HCV infection increased from 640 (495, 842) cases in 2008 to 1260 (1060, 1500). The mean time from initiation of injecting drug use to HCV acquisition decreased from 29 months in 2008 to 13 months in 2009. After HIV interventions, HCV incidence declined by 64.8% in 2012, compared to 2009. The averted HCV incidence cases attributed to the HIV-implemented interventions were 2200 (1950, 2480), during 2012-2015. The cumulative number incident HCV cases in Athens during 2002-2015 was about 9900 (7800, 12 100). Our results highlight that before the 2011 HIV outbreak in Athens, an HCV outbreak occurred in 2009. Prevention measures for HIV that took place in the Athens metropolitan area in 2012 reduced significantly the incidence of HCV.

Data availability is severely limited in high-altitude regions (Shea et al., 2015) mainly due to the remoteness and difficulty in accessing the sites. However, high mountain ecosystems are among the most sensitive environments to changes in climatic conditions occurring on global, regional and local scales (Ruiz et al., 2008). Due to significant warming observed globally during the recent century, the international scientific community has focused more attention to understand the cause and effect interaction on the ecosystems and their individual components to climate changes (Borgaonkar et al., 2011). In many mountain regions of the world, high altitudes appear to experience a stronger warming than the surrounding lowlands (Vuille, 2011) and that the warming is more closely related to an increase in daily minimum temperature than a change in the daily maximum (Diaz and Bradley, 1997; Beniston, 2006; Giambelluca et al., 2008). The main objective of this study is to evaluate the variability of meteorological parameters measured by two high altitude meteorological stations (OITI and KALLIDROMO) that have never been analyzed before, located in two mountainous Natura 2000 sites of Central Greece, in the Region of Sterea Ellada (Figure 1). The stations were settled in the framework of the Project: Conservation of priority forests and forest openings in "Ethnikos Drymos Oitis" and "Oros Kallidromo" of Sterea Ellada. The data sets recorded in the meteorological stations cover the periods 2014-2018.

Optomagnonic cavities have recently been emerging as promising candidates for implementing coherent photon-magnon interactions, for applications in quantum memories and devices, and next generation quantum networks. A key challenge in the design of such cavities is the attainment of high magnon-mediated optical-to-optical conversion efficiencies, which could, e.g., be exploited for efficient optical interfacing of superconducting qubits, as well as the practicality of the final designs, which ideally should be planar and amenable to on-chip integration. Here, on the basis of a novel time-Floquet scattering-matrix approach, we report on the design and optimization of a planar, multilayer optomagnonic cavity, incorporating a cerium-substituted yttrium iron garnet thin film, magnetized in-plane, and operating in the triple-resonant inelastic light scattering regime. This architecture allows for magnon-mediated optical-to-optical conversion efficiencies of about 5% under realistic conditions, which is orders of magnitude higher than that attained in alternative optomagnonic designs. Our results suggest a viable way forward for realizing practical information inter-conversion, with high efficiencies, between microwaves, strongly coupled to magnons, and optical photons, as well as a platform for fundamental studies of classical and quantum dynamics in magnetic solids and for the implementation of futuristic quantum devices.

Young rifts are shaped by combined tectonic and surface processes and climate, yet few records exist to evaluate the interplay of these processes over an extended period of early rift-basin development. Here, we present the longest and highest resolution record of sediment flux and paleoenvironmental changes when a young rift connects to the global oceans. New results from International Ocean Discovery Program (IODP) Expedition 381 in the Corinth Rift show 10s–100s of kyr cyclic variations in basin paleoenvironment as eustatic sea level fluctuated with respect to sills bounding this semi-isolated basin, and reveal substantial corresponding changes in the volume and character of sediment delivered into the rift. During interglacials, when the basin was marine, sedimentation rates were lower (excepting the Holocene), and bioturbation and organic carbon concentration higher. During glacials, the basin was isolated from the ocean, and sedimentation rates were higher (~2–7 times those in interglacials). We infer that reduced vegetation cover during glacials drove higher sediment flux from the rift flanks. These orbital-timescale changes in rate and type of basin infill will likely influence early rift sedimentary and faulting processes, potentially including syn-rift stratigraphy, sediment burial rates, and organic carbon flux and preservation on deep continental margins worldwide.

BACKGROUND: Knowledge of HIV-1 molecular transmission clusters (MTCs) is important, especially in large-scale datasets, for designing prevention programmes and public health intervention strategies. We used a large-scale HIV-1 sequence dataset from nine European HIV cohorts and one Canadian, to identify MTCs and investigate factors associated with the probability of belonging to MTCs. METHODS: To identify MTCs, we applied maximum likelihood inferences on partial pol sequences from 8955 HIV-positive individuals linked to demographic and clinical data. MTCs were defined using two different criteria: clusters with bootstrap support >75% (phylogenetic confidence criterion) and clusters consisting of sequences from a specific region at a proportion of >75% (geographic criterion) compared to the total number of sequences within the network. Multivariable logistic regression analysis was used to assess factors associated with MTC clustering. RESULTS: Although 3700 (41%) sequences belonged to MTCs, proportions differed substantially by country and subtype, ranging from 7% among UK subtype C sequences to 63% among German subtype B sequences. The probability of belonging to an MTC was independently less likely for women than men (OR = 0.66; P < 0.001), older individuals (OR = 0.79 per 10-year increase in age; P < 0.001) and people of non-white ethnicity (OR = 0.44; P < 0.001 and OR = 0.70; P = 0.002 for black and 'other' versus white, respectively). It was also more likely among men who have sex with men (MSM) than other risk groups (OR = 0.62; P < 0.001 and OR = 0.69; P = 0.002 for people who inject drugs, and sex between men and women, respectively), subtype B (ORs 0.36-0.70 for A, C, CRF01 and CRF02 versus B; all P < 0.05), having a well-estimated date of seroconversion (OR = 1.44; P < 0.001), a later calendar year of sampling (ORs 2.01-2.61 for all post-2002 periods versus pre-2002; all P < 0.01), and being naïve to antiretroviral therapy at sampling (OR = 1.19; P = 0.010). CONCLUSIONS: A high proportion (>40%) of individuals belonged to MTCs. Notably, the HIV epidemic dispersal appears to be driven by subtype B viruses spread within MSM networks. Expansion of regional epidemics seems mainly associated with recent MTCs, rather than the growth of older, established ones. This information is important for designing prevention and public health intervention strategies.

In this paper, we focus on the southeastern coastal zone of the island of Samos (east-central Aegean Sea), in order to reconstruct the evolution of coastal landscapes and the relative sea-level changes during the late Holocene. We use geomorphological mapping, sedimentological and palaeontological proxies of late Holocene coastal deposits from two lagoon environments. We further compare our results with previously published sea-level data and we show that the southeastern part of Samos was characterized by a subsidence trend at least during the late Holocene, with RSL rise rates of ∼0.8 mm/yr. Our study additionally highlights that local-scale tectonics is responsible for the evolution of the coastal zone of Samos.

We present the discovery of HD 221416 b, the first transiting planet identified by the Transiting Exoplanet Survey Satellite (TESS) for which asteroseismology of the host star is possible. HD 221416 b (HIP 116158, TOI-197) is a bright (V = 8.2 mag), spectroscopically classified subgiant that oscillates with an average frequency of about 430 μHz and displays a clear signature of mixed modes. The oscillation amplitude confirms that the redder TESS bandpass compared to Kepler has a small effect on the oscillations, supporting the expected yield of thousands of solar-like oscillators with TESS 2 minute cadence observations. Asteroseismic modeling yields a robust determination of the host star radius (R ⋆ = 2.943 ± 0.064 R ⊙), mass (M ⋆ = 1.212 ± 0.074 M ⊙), and age (4.9 ± 1.1 Gyr), and demonstrates that it has just started ascending the red-giant branch. Combining asteroseismology with transit modeling and radial-velocity observations, we show that the planet is a “hot Saturn” (R p = 9.17 ± 0.33 R ⊕) with an orbital period of ∼14.3 days, irradiance of F = 343 ± 24 F ⊕, and moderate mass (M p = 60.5 ± 5.7 M ⊕) and density (ρ p = 0.431 ± 0.062 g cm-3). The properties of HD 221416 b show that the host-star metallicity-planet mass correlation found in sub-Saturns (4-8 R ⊕) does not extend to larger radii, indicating that planets in the transition between sub-Saturns and Jupiters follow a relatively narrow range of densities. With a density measured to ∼15%, HD 221416 b is one of the best characterized Saturn-size planets to date, augmenting the small number of known transiting planets around evolved stars and demonstrating the power of TESS to characterize exoplanets and their host stars using asteroseismology.

Students’ knowledge about the criteria for an upcoming test is a crucial component of assessment quality. Grounded in self-determination theory, we investigated whether knowledge about the criteria for an upcoming test related to students’ situational motivation and experienced anxiety during physical education (PE). We also examined whether these relations were: (a) mediated by need-based experiences; and (b) moderated by teachers’ motivating style. Participants were 659 students (55.54% boys, 44.46% girls, mean age 14.72 years, standard deviation = 0.94) out of 40 classes from 32 schools taught by 39 different PE teachers. Analyses through multilevel structural equation modeling showed that students with more knowledge about the criteria for an upcoming test valued and enjoyed the lesson more (i.e. autonomous motivation), and felt less aloof (i.e. amotivation). Relations between knowledge about the criteria and students’ situational motivation were mediated by experienced need satisfaction. Specifically, students who had more knowledge about the criteria for an upcoming test felt more in charge of their learning process (i.e. autonomy satisfaction), felt more effective in reaching their goals (i.e. competence satisfaction) and felt more connected to the teacher (i.e. relatedness satisfaction). Although relations between knowledge about the criteria and students’ motivation were not moderated by teachers’ motivating style, teachers’ motivating style displayed independent relations with students’ motivation. Implications for assessment quality and students’ motivation in PE are discussed.

OBJECTIVES: Human papillomavirus-related oropharyngeal squamous cell carcinoma (HPV+ OPSCC) is increasing in incidence. Although HPV+ OPSCC has favorable prognosis, 10 to 25% of HPV+ OPSCCs eventually recur. We sought to evaluate the feasibility of detection of HPV16 E6/E7 expression in Circulating Tumor Cells (CTCs) and its utility as a prognostic tool in HPV16-associated OPSCC. MATERIALS AND METHODS: We developed a highly sensitive RT-qPCR assay for HPV mRNA expression in EpCAM(+) CTCs. In 22 patients with early stage and locally advanced OPSCC we evaluated HPV16 E6/E7 expression in the EpCAM(+) CTC fraction at baseline and at the end of concurrent chemoradiotherapy. HPV status in pre-therapy formalin-fixed paraffin-embedded (FFPE) tumor biopsies was assessed by p16 immunohistochemistry and polymerase chain reaction (PCR) and double positives were subjected to Real-time qPCR assay for detection of HPV16, 18 and 31 types. RESULTS: Fourteen of 22 OPSCC (63.6%) were HPV DNA+/p16+. Among HPV+/p16+ patients, 10 patients (71.4%) were HPV16 DNA+. HPV16 E6/E7(+) CTCs were detected in 3 of 10 patients (30%) at baseline and 4 of 9 patients (44.4%) at the end-of-treatment, all of which were p16+/HPV16 DNA+. Survival analysis showed a significantly higher risk for disease relapse (p = 0.001) and death (p = 0.005) in patients with HPV16 E6/E7(+) baseline CTCs. CONCLUSION: Detection of HPV E6/E7(+) CTCs might be a useful noninvasive test in liquid biopsy samples for determination of a clinically relevant HPV infection in HPV+ OPSCC. Combined interpretation of HPV E6/E7(+) CTCs with UICC staging data may lead to alteration of risk definition of patient subsets, with improved risk discrimination in early-stage disease.

OBJECTIVES: Human papillomavirus-related oropharyngeal squamous cell carcinoma (HPV+ OPSCC) is increasing in incidence. Although HPV+ OPSCC has favorable prognosis, 10 to 25% of HPV+ OPSCCs eventually recur. We sought to evaluate the feasibility of detection of HPV16 E6/E7 expression in Circulating Tumor Cells (CTCs) and its utility as a prognostic tool in HPV16-associated OPSCC. MATERIALS AND METHODS: We developed a highly sensitive RT-qPCR assay for HPV mRNA expression in EpCAM(+) CTCs. In 22 patients with early stage and locally advanced OPSCC we evaluated HPV16 E6/E7 expression in the EpCAM(+) CTC fraction at baseline and at the end of concurrent chemoradiotherapy. HPV status in pre-therapy formalin-fixed paraffin-embedded (FFPE) tumor biopsies was assessed by p16 immunohistochemistry and polymerase chain reaction (PCR) and double positives were subjected to Real-time qPCR assay for detection of HPV16, 18 and 31 types. RESULTS: Fourteen of 22 OPSCC (63.6%) were HPV DNA+/p16+. Among HPV+/p16+ patients, 10 patients (71.4%) were HPV16 DNA+. HPV16 E6/E7(+) CTCs were detected in 3 of 10 patients (30%) at baseline and 4 of 9 patients (44.4%) at the end-of-treatment, all of which were p16+/HPV16 DNA+. Survival analysis showed a significantly higher risk for disease relapse (p = 0.001) and death (p = 0.005) in patients with HPV16 E6/E7(+) baseline CTCs. CONCLUSION: Detection of HPV E6/E7(+) CTCs might be a useful noninvasive test in liquid biopsy samples for determination of a clinically relevant HPV infection in HPV+ OPSCC. Combined interpretation of HPV E6/E7(+) CTCs with UICC staging data may lead to alteration of risk definition of patient subsets, with improved risk discrimination in early-stage disease

Studies of the massive star population in galaxies beyond the Local Group are the key to understanding the link between their numbers and modes of star formation in different environments. We present the analysis of the massive star population of the galaxies NGC 1326A, NGC 1425, and NGC 4548 using archival images obtained with the Hubble Space Telescope Wide Field Planetary Camera 2 in the F555W and F814W filters. Through high-precision point spread function fitting photometry for all sources in the three fields, we identified 7640 candidate blue supergiants, 2314 candidate yellow supergiants, and 4270 candidate red supergiants. We provide an estimate of the ratio of blue to red supergiants for each field as a function of galactocentric radius. Using Modules for Experiments in Stellar Astrophysics (MESA) at solar metallicity, we defined the luminosity function and estimated the star formation history of each galaxy. We carried out a variability search in the V and I filters using three variability indexes: the median absolute deviation, the interquartile range, and the inverse von Neumann ratio. This analysis yielded 243 new variable candidates with absolute magnitudes ranging from MV = -4 to -10 mag. We classified the variable stars based on their absolute magnitude and their position on the color-magnitude diagram using the MESA evolutionary tracks at solar metallicity. Our analysis yielded 8 candidate variable blue supergiants, 12 candidate variable yellow supergiants, 21 candidate variable red supergiants, and 4 candidate periodic variables. Full Tables 1, 2, 3, and Tables 6-10 are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/629/A3

Aims: Over its lifetime and despite not being a survey telescope, the Hubble Space Telescope (HST) has obtained multi-epoch observations by multiple, diverse observing programs, providing the opportunity for a comprehensive variability search aiming to uncover new variables. We have therefore undertaken the task of creating a catalog of variable sources based on archival HST photometry. In particular, we have used version 3 of the Hubble Source Catalog (HSC), which relies on publicly available images obtained with the WFPC2, ACS, and WFC3 instruments onboard the HST. Methods: We adopted magnitude-dependent thresholding in median absolute deviation (a robust measure of light curve scatter) combined with sophisticated preprocessing techniques and visual quality control to identify and validate variable sources observed by Hubble with the same instrument and filter combination five or more times. Results: The Hubble Catalog of Variables (HCV) includes 84 428 candidate variable sources (out of 3.7 million HSC sources that were searched for variability) with V ≤ 27 mag; for 11 115 of them the variability is detected in more than one filter. The data points in the light curves of the variables in the HCV catalog range from five to 120 points (typically having less than ten points); the time baseline ranges from under a day to over 15 years; while ˜8% of all variables have amplitudes in excess of 1 mag. Visual inspection performed on a subset of the candidate variables suggests that at least 80% of the candidate variables that passed our automated quality control are true variable sources rather than spurious detections resulting from blending, residual cosmic rays, and calibration errors. Conclusion. The HCV is the first, homogeneous catalog of variable sources created from the highly diverse, archival HST data and currently is the deepest catalog of variables available. The catalog includes variable stars in our Galaxy and nearby galaxies, as well as transients and variable active galactic nuclei. We expect that the catalog will be a valuable resource for the community. Possible uses include searches for new variable objects of a particular type for population analysis, detection of unique objects worthy of follow-up studies, identification of sources observed at other wavelengths, and photometric characterization of candidate progenitors of supernovae and other transients in nearby galaxies. The catalog is available to the community from the ESA Hubble Science Archive (eHST) at the European Space Astronomy Centre (ESAC) and the Mikulski Archive for Space Telescopes (MAST) at Space Telescope Science Institute (STScI). Full Tables B.2 and B.3 are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/cat/J/A+A/630/A92

The Hubble Source Catalog (HSC) combines lists of sources detected on images obtained with the WFPC2, ACS and WFC3 instruments aboard the Hubble Space Telescope (HST) and now available in the Hubble Legacy Archive. The catalogue contains time-domain information for about two million of its sources detected using the same instrument and filter on at least five HST visits. The Hubble Catalog of Variables (HCV) aims to identify HSC sources showing significant brightness variations. A magnitude-dependent threshold in the median absolute deviation of photometric measurements (an outlier-resistant measure of light-curve scatter) is adopted as the variability detection statistic. It is supplemented with a cut in χred2 that removes sources with large photometric errors. A pre-processing procedure involving bad image identification, outlier rejection and computation of local magnitude zero-point corrections is applied to the HSC light-curves before computing the variability detection statistics. About 52 000 HSC sources have been identified as candidate variables, among which 7,800 show variability in more than one filter. Visual inspection suggests that ~70% of the candidates detected in multiple filters are true variables, while the remaining ~30% are sources with aperture photometry corrupted by blending, imaging artefacts or image processing anomalies. The candidate variables have AB magnitudes in the range 15-27m, with a median of 22m. Among them are the stars in our own and nearby galaxies, and active galactic nuclei.

Identifying and linking people to care soon after HIV infection could limit viral transmission and protect their health. This work aims at describing the continuum of care among recently HIV-infected people who inject drugs (PWID) and participated in an intervention in the context of an HIV outbreak in Athens, Greece. The Transmission Reduction Intervention Project (TRIP) conducted risk network-based contact tracing and screened people for recent HIV infection. A comprehensive approach with a case management component that aimed to remove barriers to accessing care was adopted. Follow-up data on antiretroviral treatment (ART) and HIV-RNA levels were obtained from HIV clinics. TRIP enrolled 45 recently HIV-infected PWID (80% male) with a median viral load at recruitment of 5.43 log(10) copies/mL. Of the recently infected persons in TRIP, 87% were linked to care; of these, 77% started ART; and of those on ART, 89% achieved viral load <200 copies/mL. TRIP and its public health allies managed to get most of the recently HIV-infected PWID who were identified by the program into care and many of them onto ART. This resulted in very low HIV-RNA levels. Treatment as prevention can work if individuals are aided in overcoming difficulties in entry to, or attrition from care.

For several years, Greece has set as a priority the strengthening of maritime tourism, such as the tourism of yachts for which tourist marinas have been created. The most important marinas of the country include the “Glyfada Marina”, whose works began on the coastal front after 1960, thus changing the area’s shape and planning. The main objective of the present work is to investigate the improvement measures and prospects for the development of the “Glyfada Marina” consisting of four basins, being one of the most beautiful and developed marinas in the country since it is an important attraction for tourist yachts.

For several years, Greece has set as a priority the strengthening of maritime tourism, such as the tourism of yachts for which tourist marinas have been created. The most important marinas of the country include the “Glyfada Marina”, whose works began on the coastal front after 1960, thus changing the area’s shape and planning. The main objective of the present work is to investigate the improvement measures and prospects for the development of the “Glyfada Marina” consisting of four basins, being one of the most beautiful and developed marinas in the country since it is an important attraction for tourist yachts. For this reason, on-site visits to the port area were carried out, both on the sea and on the coastal part of the coastal zone, in order to record the current situation, so as to reach as accurately as possible the characteristics and the range of the internal port works and facilities of the aforementioned tourist port. Furthermore, any deficiencies or failures that need improvement are presented, labeled and classified in order to continue unhindered activities in the marina area. Finally, improvement and upgrading measures are proposed that can contribute positively to the tourist and economic development of the port and the municipality of Glyfada in general. 

Expedition 381 scientists Donna J. Shillington Co-Chief Scientist Lamont-Doherty Earth Observatory Columbia University USA Lisa C. McNeill Co-Chief Scientist Ocean and Earth Science University of Southampton National Oceanography Centre Southampton UK Gareth D.O. CarterExpedition Project Manager British Geological Survey The Lyell Centre UKJeremy (Jez) Everest Expedition Project Manager British Geological Survey The Lyell Centre UKErwan Le BerPetrophysics Staff Scientist School of Geography, Geology and the Environment University of Leicester UK Richard Collier Sedimentologist Basin Structure Group School of Earth and Environment University of Leeds UK Aleksandra Cvetkoska Micropaleontologist (diatoms) Department of Animal Ecology and Systematics Justus Liebig University Germany Gino De Gelder Structural Geologist Institut de Physique du Globe de Paris Sorbonne Paris Cité Université Paris Diderot France Paula Diz FerreiroMicropaleontologist (foraminifers) Departamento Geociencias Marinas y Ordenación del Territorio Facultad de Ciencias del Mar Universidad de Vigo Spain Mai-Linh Doan Petrophysicist (physical properties) Université Grenoble Alpes Université Savoie Mont Blanc CNRS, IRD, IFSTTAR, and ISTerre France Mary Ford Structural Geologist/Sedimentologist CRPG UMR 7358 France Also at Université de Lorraine ENSG INP France Robert GawthorpeSedimentologist Department of Earth Science University of Bergen Norway Maria Geraga Micropaleontologist (foraminifers) Department of Geology University of Patras Greece Jack Gillespie Structural Geologist/Sedimentologist Center for Tectonics, Resources, and Exploration (TRaX) Department of Earth Sciences School of Physical Sciences University of Adelaide AustraliaRomain Hemelsdaël Sedimentologist Géosciences Montpellier Université de Montpellier France Emilio Herrero-Bervera Paleomagnetist University of Hawaii at Manoa Hawaii Institute of Geophysics and Planetology USAMohammad Ismaiel Petrophysicist (physical properties) University Centre for Earth and Space Sciences University of Hyderabad India Liliane Janikian Sedimentologist Departamento de Ciências do Mar Universidade Federal de São Paulo BrazilKaterina Kouli Micropaleontologist (palynology) Department of Geology and Geoenvironment National and Kapodistrian University of Athens Greece Shunli Li Sedimentologist School of Energy Resources China University of Geosciences (Beijing) China Malka Leah Machlus Petrophysicist (physical properties) Lamont-Doherty Earth Observatory Columbia University USA Also at Department of Physical Sciences Kingsborough Community College City University of New York USA Marco MaffionePaleomagnetist School of Geography Earth and Environmental Sciences University of Birmingham UK Carol Mahoney Inorganic Geochemist School of Earth and Environment The University of Leeds UK Georgios Michas Petrophysicist (physical properties) Laboratory of Geophysics and Seismology Technological Educational Institute of Crete Greece Clint Miller Inorganic Geochemist Department of Earth, Environmental and Planetary Sciences Rice University USA Casey Nixon Structural Geologist Department of Earth Science University of Bergen NorwaySabire Asli Oflaz Micropaleontologist (foraminifers) Graduate School “Human Development in Landscapes” Christian-Albrechts-Universität zu Kiel Germany Abah Philip Omale Petrophysicist (physical properties) Department of Geology and Geophysics Louisiana State University USAKostas Panagiotopoulos Micropaleontologist (palynology) Institute of Geology and Mineralogy University of Cologne Germany Sofia Pechlivanidou Sedimentologist Department of Earth Science University of Bergen Norway Marcie Phillips Micropaleontologist (nannofossils/diatoms) Institute for Geophysics University of Texas at Austin USA Simone Sauer Inorganic Geochemist Ifremer Department of Marine Geosciences Centre Bretagne France Joana Seguin Organic Geochemist Institute for Ecosystem Research Christian-Albrechts-Universität zu Kiel GermanySpyros Sergiou Sedimentologist Laboratory of Marine Geology and Physical Oceanography Department of Geology University of Patras Greece Natalia Zakharova Core-Log-Seismic Integration Department of Earth and Atmospheric Sciences Central Michigan University USA

Taking as a point of departure Lord Byron’s reflections on the meaning of the ruined Parthenon, this essay traverses the long legacy of ruin-thinking in the Anglo-American imagination, and argues for its relevance to the present day. Referencing earlier and recent strands in the rich scholarship on the trope of the ruin, the authors contextualize the essays of the volume; particular emphasis is laid on the volume’s especial focus on the ruin as metaphor and as a historical materiality, as these are probed in individual chapters that discuss ruin and ruination across British and American literature, continental theory and philosophy.

Introduction to vol. 23/1  NARRATIVES OF RELIGIOUS CONVERSION FROM THE ENLIGHTENMENT TO THE PRESENT, ed. by L. Kostova nad E. Mitsi

Inverse Compton-pair cascades are initiated when gamma-rays are absorbed on an ambient soft photon field to produce relativistic pairs, which in turn up-scatter the same soft photons to produce more gamma-rays. If the Compton scatterings take place in the deep Klein-Nishina regime, then triplet pair production (e{γ }b\to {{ee}}+{e}-) becomes relevant and may even regulate the development of the cascade. We investigate the properties of pair-Compton cascades with triplet pair production in accelerating gaps, i.e., regions with an unscreened electric field. Using the method of transport equations for the particle evolution, we compute the growth rate of the pair cascade as a function of the accelerating electric field in the presence of blackbody and power-law ambient photon fields. Informed by the numerical results, we derive simple analytical expressions for the peak growth rate and the corresponding electric field. We show that for certain parameters, which can be realized in the vicinity of accreting supermassive black holes at the centers of active galactic nuclei, the pair cascade may well be regulated by inverse Compton scattering in the deep Klein-Nishina regime and triplet pair production. We present indicative examples of the escaping gamma-ray radiation from the gap, and discuss our results in application to the TeV observations of radio galaxy M87.

Inverse Compton-pair cascades are initiated when gamma-rays are absorbed on an ambient soft photon field to produce relativistic pairs, which in turn up-scatter the same soft photons to produce more gamma-rays. If the Compton scatterings take place in the deep Klein-Nishina regime, then triplet pair production (e{γ }b\to {{ee}}+{e}-) becomes relevant and may even regulate the development of the cascade. We investigate the properties of pair-Compton cascades with triplet pair production in accelerating gaps, i.e., regions with an unscreened electric field. Using the method of transport equations for the particle evolution, we compute the growth rate of the pair cascade as a function of the accelerating electric field in the presence of blackbody and power-law ambient photon fields. Informed by the numerical results, we derive simple analytical expressions for the peak growth rate and the corresponding electric field. We show that for certain parameters, which can be realized in the vicinity of accreting supermassive black holes at the centers of active galactic nuclei, the pair cascade may well be regulated by inverse Compton scattering in the deep Klein-Nishina regime and triplet pair production. We present indicative examples of the escaping gamma-ray radiation from the gap, and discuss our results in application to the TeV observations of radio galaxy M87.

Aims: We investigate accretion models for the newly discovered pulsating ultraluminous X-ray source (ULX) NGC 300 ULX1. Methods: We analyzed broadband XMM-Newton and NuSTAR observations of NGC 300 ULX1, performing phase-averaged and phase-resolved spectroscopy. Using the Bayesian framework, we compared two physically motivated models for the source spectrum: Non-thermal accretion column emission modeled by a power law with a high-energy exponential roll-off (AC model), and multicolor thermal emission from an optically thick accretion envelope plus a hard power-law tail (MCAE model). The AC model is an often used phenomenological model for the emission of X-ray pulsars, while the MCAE model has recently been proposed for the emission of the optically thick accretion envelope that is expected to form in ultraluminous (LX > 1039 erg s-1), highly magnetized accreting neutron stars. We combined the findings of our Bayesian analysis with qualitative physical considerations to evaluate the suitability of each model. Results: The low-energy part (< 2 keV) of the source spectrum is dominated by non-pulsating, multicolor thermal emission. The (pulsating) high-energy continuum is more ambiguous. If modeled with the AC model, a residual structure is detected that can be modeled using a broad Gaussian absorption line centered at ∼12 keV. However, the same residuals can be successfully modeled using the MCAE model, without the need for the absorption-like feature. Model comparison using the Bayesian approach strongly indicates that the MCAE model without the absorption line is the preferred model. Conclusions: The spectro-temporal characteristics of NGC 300 ULX1 are consistent with previously reported traits for X-ray pulsars and (pulsating) ULXs. All models considered strongly indicate the presence of an accretion disk that is truncated at a large distance from the central object, as has recently been suggested for a large portion of both pulsating and non-pulsating ULXs. The hard, pulsed emission is not described by a smooth spectral continuum. If modeled by a broad Gaussian absorption line, the fit residuals can be interpreted as a cyclotron scattering feature (CRSF) compatible with a ∼1012 G magnetic field. However, the MCAE model can successfully describe the spectral and temporal characteristics of the source emission, without the need for an additional absorption feature, and it yields physically meaningful parameter values. Therefore strong doubts are cast on the presence of a CRSF in NGC 300 ULX1.

“Jazz mapping" is a multi-layered analytical approach to jazz improvisation. It is based on hierarchical segmentation and categorization of segments, or constituents, according to their function in the overall improvisation. The approach aims at identifying higher-level semantics oftranscribed and recorded jazz solos. At these initial stages, analytical decisions are rather exploratory and rely on the input of one of the authors and experienced jazz performer. We apply the method to two well-known solos, by Sonny Rollins and Charlie Parker, and discuss how improvisations resemble story-telling, employing a broad range of structural, expressive and technical tools, usually associated with linguistic production, experience, and meaning. We elucidate the implicit choices of experienced jazz improvisers, who have developed a strong command over the language and can communicate expressive intent, elicit emotional responses, and unfoldmusical “stories” that are memorable and enjoyable tofellow musicians and listeners. We also comment on potentialartificial intelligence applications of this work to music research and performance.

On July 20, 2017 22:31 UTC, a strong Mwþinspace}=þinspace}6.6 earthquake occurred at shallow depth between Kos Island (Greece) and Bodrum (Turkey). We derive a co-seismic fault model from joint inversion of geodetic data (GNSS and InSAR) assuming that the earthquake can be modelled by the slip of a rectangular fault buried in an elastic and homogeneous half-space. The GNSS observations constrain well most of the model parameters but do not permit to discriminate between south- and north-dipping planes. However, the interferograms, produced from C-band ESA Sentinel 1 data, give a clear preference to the north-dipping plane. We also map surface motion away from the satellite along the Turkish coast (from Bodrum towards the east) which reached about 17 cm onshore islet Karaada. The best-fit model is obtained with a 37° north-dipping, N283°E striking normal fault, in agreement with the published moment tensor solutions. The resolved slip vector is dominantly normal with a slight component of left-lateral motion (15°). The surface projection of the seismic fault outcrops in the Gökova ridge area, a well-developed bathymetric feature inside the western Gulf of Gökova. Our geodetic model fits the pattern of the shallow, north-dipping aftershocks obtained from rigorous relocation of all available recordings in the region (about 1120 events; relocated mainshock is at 36.955°N, 27.448°E; depth at 9.2 kmþinspace}±þinspace}0.5 km). The relocated aftershocks also indicate clustering at both ends of the rupture and seismicity triggering mainly towards the east and the north, within 2 weeks following the mainshock. We also analysed regional GPS data (interseismic velocities) and obtained an extension rate of 3.2 mm/yr across the Gökova rift, along a direction N165°E.

The objective of this study is to analyze the kinetic and kinematic changes of the osteoarthritic knee after a mobile bearing total knee arthroplasty. Kinematic and kinetic gait analysis of level walking was performed in 15 patients (eight female and seven male) with knee ostoarthritis. All patients were free of any neurological diseases that could affect their normal gait. Mean age was 68.6 ± 5.2 years, mean height 159.8 ± 6.9 cm, and mean weight was 78.5 ± 10.1 kg. Full body gait analysis was performed using the BioKin three-dimensional (3D) motion analysis system preoperatively and 9 months after total knee arthroplasty. A single-step ascending kinetic analysis and a plantar pressure distribution analysis were also performed in all patients. An increased average cadence (mean 99.39 step/min preoperatively and 104.64 step/min postoperatively;  = 0.152), step length (0.44 m preoperatively and 0.52 m postoperatively;  < 0.001), stride length (0.89 m preoperatively and 1.0 m postoperatively;  < 0.007), and walking velocity (0.73 m/sec preoperatively and 0.90 m/sec postoperatively;  = 0.005) were noted postoperatively and postoperatively. A decrease in the stance duration percentage and the knee adduction moment was also reported postoperatively. All patients showed a significant improvement of knee kinetics and kinematics after a mobile bearing total knee arthroplasty. Statistically significant differences were found in the step length, stride length, and walk velocity postoperatively. The knee adduction moment was also significantly reduced. Further research is warranted to determine the clinical relevance of these findings. This study is a prospective comparative one and reflects level II evidence.

El presente trabajo pretende demostrar que la prueba de disponibilidad léxica puede servir como herramienta de evaluación léxica de aprendices de LE. Partiendo del hecho de que la competencia léxica es multidimensional se puede entender que evaluarla es una tarea muy compleja. A pesar de que la prueba de la disponibilidad léxica no puede medir todos los aspectos que abarca la competencia léxica, pensamos que podría ser una herramienta útil de evaluación de algunos aspectos del conocimiento léxico que atiende a dos finalidades diferentes: la evaluación del desarrollo de estos aspectos del conocimiento léxico de los aprendices de LE y la localización de posibles lagunas léxicas en el área temática analizada. Para comprobarlo, sometemos a dos grupos de aprendices griegos de ELE de nivel B1 y C1 respectivamente a la realización de una prueba de disponibilidad léxica. Comparamos sus respuestas en el centro de interés “La casa” para observar cómo evolucionan diferentes aspectos de su conocimiento léxico. A continuación, cotejamos las respuestas de los dos grupos con el Capítulo 10 (“Vivienda”) de las “Nociones específicas” del PCIC. Los resultados muestran que la prueba de la disponibilidad léxica podría revelar las lagunas del conocimiento léxico en el área temática analizada a condición de que se haya utilizado un centro de interés que permita la producción de todas las categorías gramaticales de las palabras.

El presente trabajo pretende demostrar que las pruebas de disponibilidadléxica pueden servir como pruebas de diagnóstico, yque por ello son de gran ayuda a la hora de decidir qué palabrasenseñar e incluir en una clase de ELE. Diagnosticar el conocimientoléxico es una tarea muy compleja, dado que conocer unapalabra se compone de muchas dimensiones distintas. A pesar dela crítica que ha recibido la metodología de las pruebas de la disponibilidadléxica, pensamos que podría ser una herramienta útilpara identificar las posibles lagunas en el conocimiento de losaprendices de ELE. En este estudio en concreto sometemos a ungrupo de estudiantes griegos de ELE de nivel B1 a la realizaciónde una prueba de disponibilidad léxica. Analizamos aspectos cuantitativosy cualitativos de las respuestas en el centro de interés“Comidas y bebidas” y las comparamos con las “Nociones específicas”del Plan Curricular del Instituto Cervantes. Los resultadosindican que dicha comparación nos permite localizar las carenciasléxicas en el área temática analizada. En este sentido, las pruebasde disponibilidad léxica pueden servir como pruebas de diagnóstico,y podríamos basarnos en sus resultados para planificar nuestraclase antes de empezar a trabajar en el aula un área temáticaconcreta.

El presente trabajo pretende investigar la influencia del conocimiento de varias lenguas extranjeras en la evocación del léxico disponible de aprendices griegos de español. A pesar de que existe la creencia de la existencia de una relación positiva entre el conocimiento de lenguas extranjeras y la disponibilidad léxica, en la investigación encontramos resultados contradictorios. Por una parte, algunas investigaciones han dado prueba de los beneficios lingüísticos del multilingüismo, por otra, hay estudios en psicolingüística que han mostrado que los hablantes multilingües necesitan más tiempo para activar y recuperar las palabras que los monolingües. En este estudio en concreto, sometemos a tres grupos de estudiantes del mismo nivel en español (B2) pero que conocen diferentes lenguas extranjeras a una prueba de disponibilidad léxica. Específicamente, analizamos las respuestas de un grupo de aprendices griegos de español que conocen una lengua extranjera, aparte de la lengua materna y el español, otro que conoce dos lenguas extranjeras, y un grupo que conoce tres lenguas extranjeras y más. Analizamos aspectos cuantitativos y cualitativos de las respuestas en el centro de interés ¨Acciones diarias¨. Los resultados muestran por un lado la relación positiva entre el conocimiento de lenguas extranjeras y la cantidad de respuestas evocadas y por otro la influencia del número de lenguas extranjeras conocidas en el uso de las estrategias de evocación empleadas.   

© 2019, The International Urogynecological Association. Introduction and hypothesis: Fractional CO2 and vaginal erbium lasers have emerged as potential treatment options for genitourinary syndrome of menopause (GSM) in breast cancer (BC) survivors. Methods: We conducted a systematic review of the literature to ascertain whether available evidence supports the efficacy and safety of laser treatment for GSM in BC patients. MEDLINE, Scopus and Cochrane Library databases were systematically searched from inception until March 2019 for studies on laser treatment for GSM in BC patients. Results: We yielded six observational studies meeting the inclusion criteria. The studies were of moderate quality. Taken together, the studies suggest that laser treatment may significantly alleviate or resolve the GSM-related symptoms and improve sexual function. Furthermore, a significant increase of the vaginal health index was reported. Positive effect was maintained up to 12 months. The safety and tolerability profile is encouraging, given that no adverse effects were reported, while only few patients discontinued laser treatment, owing to reported discomfort. Conclusions: Our findings suggest that lasers appear to be effective and practical treatment options in BC survivors suffering from GSM. Evidence concerning long-term effects is lacking. The rationale for repeated treatment remains uncertain. Randomized controlled trials that collate different frequencies, intensities and durations are warranted to ascertain a dose-response relationship and adherence.

Different types of sea-level markers have been used in the Eastern Mediterranean in order to assess Late Quaternary coastal evolution and relative sea-level (RSL) changes. RSL reconstructions are useful for various researches, ranging from the investigation of crustal movements to the calibration of earth rheology models and ice sheet reconstructions. GIA models have often been employed to identify stableand unstable areas and deduce tectonic rates through comparisons with observational data. It is generally assumed that most Cycladic islands (Aegean Sea, Greece) are affected by a gradual subsidence, ascribed to the thinning of the local earth crust and to isostatic processes that accompanied the post-glacial rise in sea level. The absence of morphological coastal features indicative of uplift, such as marine terraces or benches, elevated beachrocks, marine notches, or raised Quaternary coastal deposits, are often interpreted as an absence of local uplift.Although Paros Island presents great interest in terms of geoarchaeology, the evolution of its shoreline and RSL changes have not been studied in detail. The Island lies in the center of the Aegean Sea, in central Cyclades. In order to elucidate the RSL changes in the area and place an improved chronological constrain for the Late Holocene, we present new RSL index points, derived from sediment cores fromParos Island in combination with published geomorphological and sedimentological data from Paros and Naxos Island. Our results are further compared with sea-level predictions from two different GIA models in an attempt to better quantify the tectonic regime of the wider study area.

A fully dynamic theoretical approach to layered optomagnonic structures, based on a time Floquet scattering-matrix method, is developed. Its applicability is demonstrated on a simple design of a dual photonic-magnonic cavity, formed by sandwiching a magnetic garnet thin film between two dielectric Bragg mirrors, subject to continuous excitation of a perpendicular standing spin wave. Some remarkable phenomena, including nonlinear photon-magnon interaction effects and enhanced inelastic light scattering in the strong-coupling regime, fulfilling a triple-resonance condition, are analyzed and the limitations of the quasistatic adiabatic approximation are established.

The joint detection of gravitational waves (GWs) and γ-rays from a binary neutron star (NS) merger provided a unique view of off-axis gamma-ray bursts (GRBs) and an independent measurement of the NS merger rate. Comparing the observations of GRB170817 with those of the regular population of short GRBs (sGRBs), we show that an order unity fraction of NS mergers result in sGRB jets that breakout of the surrounding ejecta. We argue that the luminosity function of sGRBs, peaking at {≈ } 2× 10^{52} erg s^{-1}, is likely an intrinsic property of the sGRB central engine and that sGRB jets are typically narrow with opening angles θ0 ≈ 0.1. We perform Monte Carlo simulations to examine models for the structure and efficiency of the prompt emission in off-axis sGRBs. We find that only a small fraction (∼0.01-0.1) of NS mergers detectable by LIGO/VIRGO in GWs is expected to be also detected in prompt γ-rays and that GW170817-like events are very rare. For an NS merger rate of ∼1500 Gpc-3 yr-1, as inferred from GW170817, we expect within the next decade up to ∼12 joint detections with off-axis GRBs for structured-jet models and just ∼1 for quasi-spherical cocoon models where γ-rays are the result of shock breakout. Given several joint detections and the rates of their discoveries, the different structure models can be distinguished. In addition the existence of a cocoon with a reservoir of thermal energy may be observed directly in the ultraviolet, given a sufficiently rapid localization of the GW source.

We analyze the finite lifetimes of the topologically protected electrons in the surface state of Bi2Te3 and Bi2Se3 due to elastic scattering off surface vacancies and as a function of energy. The scattering rates are decomposed into surface-to-surface and surface-to-bulk contributions, giving us new fundamental insights into the scattering properties of the topological surface states (TSS). If the number of possible final bulk states is much larger than the number of final surface states, then the surface-to-bulk contribution is of importance, otherwise the surface-to-surface contribution dominates. Additionally, we find defect resonances that have a significant impact on the scattering properties of the TSS. They can strongly change the lifetime of the surface state to vary between tens of fs to ps at surface defect concentrations of 1 at%. We also see that the effective scattering angle shows a strong dependence on the Fermi surface warping. Our results compare fairly well with available experiments.

We report on the effect of lithium doping of zinc oxide used as electron-transport layer in organic solar cells based on both fullerene and non-fullerene acceptors. The experimental and theoretical results indicate that lithium ions intercalated within the ZnO lattice as dopants replace interstitial zinc defects that act as trap states and give rise to a higher electron conductivity without significantly altering work function and valence band edge. The enhanced electron carrier extraction/collection efficiency, the suppressed bimolecular and interface trap-assisted recombination losses and the higher electron mobility of the photoactive blend synergistically contribute to the superior performance of PTB7-Th:PC71BM-based fullerene devices utilizing doped ZnO layers with an optimized lithium concentration of 5 wt %. Such devices increased their maximum PCE from 8.59% (average 8.05%) to 10.05% (average 9.53%) while, simultaneously, boosting their long-term stability. Moreover, non-fullerene solar cells based on the PTB7-Th:IT-4F blend exhibited PCEs up to 8.96% and maintained more than 80% of their initial efficiency after 1000 h storage in the dark upon using the lithium modified ZnO electron transport layer. © 2019 American Chemical Society.

In Act 2 Scene 2 of Richard II, Bushy advises the Queen against ‘looking awry’ upon the King’s departure, comparing her gaze first to a perspective glass and then to a perspective picture that appears distorted unless viewed at an angle. I rely on this metaphor of anamorphosis to examine two recent productions of Richard II in Athens, both of which ‘distort’ the text and situate it in a bleak context. Viewed from the angle of the current political discontent, the 2014 and 2016 adaptations, directed by Elli Papakonstantinou and Efi Birba respectively, assume distinct meaning for the Athenian audience.

Systematic monitoring of specific targets in the optical regime was historically applied on a very narrow sample of known variable stars. The discovery of blazars in the 20th century brought to the foreground the need for new global sky surveys, covering the entire sky and fainter sources. Full-sky surveys are conducted more easily from space observatories, while radio telescopes perform follow up observations from the ground. Blazars are detected in a wide range of energies, while they exhibit strong variability in various wavelengths from γ-rays and X-rays to the optical and radio domain. This results in a detailed classification, according to their emission properties in each region. The rapid variability in optical domain makes blazars interesting targets for optical sky surveys, offering a new opportunity to study their variability in the time domain. Digital sky surveys in optical and near-IR found a fertile ground with the aid of sensitive sensors. Only a few dedicated programs are focusing on blazar variability, a trend which evolved rapidly in the last decade. Modern techniques, in combination with dedicated sky survey programs lead towards a new era of long-term monitoring of blazars, aiming towards the search or variability on various time scales. In this work, an overview of blazar optical surveys and monitoring projects is given, addressing the major points of each one, and highlighting the constraints that the long-term study of blazars will bring through future international campaigns.

This paper offers a comparative study of land use and demographic development in northern and southern Greece from the Neolithic to the Byzantine period. Results from summed probability densities (SPD) of archaeological radiocarbon dates and settlement numbers derived from archaeological site surveys are combined with results from cluster-based analysis of published pollen core assemblages to offer an integrated view of human pressure on the Greek landscape through time. We demonstrate that SPDs offer a useful approach to outline differences between regions and a useful complement to archaeological site surveys, evaluated here especially for the onset of the Neolithic and for the Final Neolithic (FN)/Early Bronze Age (EBA) transition. Pollen analysis highlight differences in vegetation between the two sub-regions, but also several parallel changes. The comparison of land cover dynamics between two sub-regions of Greece further demonstrates the significance of the bioclimatic conditions of core locations and that apparent oppositions between regions may in fact be two sides of the same coin in terms of socio-ecological trajectories. We also assess the balance between anthropogenic and climate-related impacts on vegetation and suggest that climatic variability was as an important factor for vegetation regrowth. Finally, our evidence suggests that the impact of humans on land cover is amplified from the Late Bronze Age (LBA) onwards as more extensive herding and agricultural practices are introduced.

Context. The tenuous nitrogen (N2) atmosphere on Pluto undergoes strong seasonal effects due to high obliquity and orbital eccentricity, and has recently (July 2015) been observed by the New Horizons spacecraft. Aims: The main goals of this study are (i) to construct a well calibrated record of the seasonal evolution of surface pressure on Pluto and (ii) to constrain the structure of the lower atmosphere using a central flash observed in 2015. Methods: Eleven stellar occultations by Pluto observed between 2002 and 2016 are used to retrieve atmospheric profiles (density, pressure, temperature) between altitude levels of ~5 and ~380 km (i.e. pressures from ~ 10 μbar to 10 nbar). Results: (i) Pressure has suffered a monotonic increase from 1988 to 2016, that is compared to a seasonal volatile transport model, from which tight constraints on a combination of albedo and emissivity of N2 ice are derived. (ii) A central flash observed on 2015 June 29 is consistent with New Horizons REX profiles, provided that (a) large diurnal temperature variations (not expected by current models) occur over Sputnik Planitia; and/or (b) hazes with tangential optical depth of ~0.3 are present at 4-7 km altitude levels; and/or (c) the nominal REX density values are overestimated by an implausibly large factor of ~20%; and/or (d) higher terrains block part of the flash in the Charon facing hemisphere.

Genome-wide studies in tumor cells have indicated that chromatin-modifying proteins are commonly mutated in human cancers. The lysine-specific methyltransferase 2C (KMT2C/MLL3) is a putative tumor suppressor in several epithelia and in myeloid cells. Here, we show that downregulation of KMT2C in bladder cancer cells leads to extensive changes in the epigenetic status and the expression of DNA damage response and DNA repair genes. More specifically, cells with low KMT2C activity are deficient in homologous recombination-mediated double-strand break DNA repair. Consequently, these cells suffer from substantially higher endogenous DNA damage and genomic instability. Finally, these cells seem to rely heavily on PARP1/2 for DNA repair, and treatment with the PARP1/2 inhibitor olaparib leads to synthetic lethality, suggesting that cancer cells with low KMT2C expression are attractive targets for therapies with PARP1/2 inhibitors.

El presente trabajo pretende demostrar que el nivel lingüístico en la lengua extranjera (LE) es un factor que afecta al proceso de evocación del léxico disponible en esta lenguade una manera tanto cuantitativa como cualitativa. Concretamente, este trabajo tiene como objetivo probar que en un mayor nivel lingüístico en la lengua extranjera seproducirán más respuestas, más variadas y más organizadas en el lexicón mental. En este estudio en concreto sometemos a dos grupos de participantes de diferente nivel enLE a la realización de una prueba de disponibilidad léxica. Específicamente, analizamos las respuestas de un grupo de alumnos griegos de ELE de nivel B1 y otro de nivel C1, yestudiamos aspectos cuantitativos y cualitativos de las respuestas en el centro de interés “Comidas y bebidas”. Los resultados indican que hay una relación positiva entre elnivel lingüístico y la cantidad y la variedad de respuestas evocadas. Además, estos muestran que el mayor nivel lingüístico en español favorece la creación de agrupaciones y larealización de saltos en las respuestas arrojadas por los estudiantes griegos, lo cual es una señal de una organización mejor delimitada en el lexicón mental de estos estudiantes.

The current study aims to clarify the hydrogeological regime of the deltaic valley of Pinios river (Thessaly, Greece). Its purpose is to map the existing aquifers below the deltaic plain, but also to assess the quality of their water (detect possible seawater intrusion), through the combined application of VES and TEM soundings. The results of the geophysical data processing revealed that the shallow (phreatic) aquifer is not detected throughout the entire deltaic plain, but only in the central and northern parts of the region, with thickness of 5–10 meters. Additionally, a deeper aquifer has been detected, with a maximum thickness equal to 100 meters. The interpretation of the geophysical soundings indicated that great part of the deeper aquifer has been affected by a saline intrusion that has also been noticed by hydrochemical data. Based on the fact that Pinios deltaic plain is a highly productive agricultural area, the irrigation system has to be reevaluated in order to constrain the extension of the seawater intrusion.

 

Past research has shown that, while psychological control increases the risk for adolescents’ antisocial behavior, maternal knowledge of adolescents’ activities decreases this risk. Yet, research is somewhat inconclusive about the role of psychologically controlling parenting in parental knowledge. Also, the role of both predictors in prosocial behavior remains largely unknown. In this 1-year, multi-informant, prospective study, we investigated these issues by recruiting a sample of Turkish early adolescents (N = 229, Mage = 11.89 years, SD = 0.32, 47.0% boys) and their mothers. After controlling for baseline adolescent-reported maternal knowledge, we found mother-reported psychological control to negatively predict adolescent-reported maternal knowledge 1 year later. In turn, maternal knowledge related negatively to antisocial behavior and positively to altruistic prosocial behavior (but not to instrumental prosocial behavior). These findings highlight the key role that maternal psychological control and knowledge can have in adolescents’ social functioning.

The present study is concerned with the outcomes from a training programme on addiction counselling addressed to medical students in Greece. The programme is the result of a collaborative curriculum development between KETHEA, a drug treatment organisation for heroin addicts, and HeLMSIC, a human rights organisation of medical students in Greece. The programme was developed as a response to the absence of relevant courses within the medical schools in this country. The study presents the local context in relation to heroin use, access to treatment and training curricula. The study also presents a small-scale research conducted on medical students’ beliefs and attitudes about their understanding about drug use. Research findings suggest that actions towards developing a holistic learning framework comprising core elements about drug use treatment and recovery are important for a better response to the needs of drug users and heroin addicts in Greece.

Mediterranean climates are characterized by strong seasonal contrasts between dry summers and wet winters. Changes in winter rainfall are critical for regional socioeconomic development, but are difficult to simulate accurately and reconstruct on Quaternary timescales. This is partly because regional hydroclimate records that cover multiple glacial–interglacial cycles, with different orbital geometries, global ice volume and atmospheric greenhouse gas concentrations are scarce. Moreover, the underlying mechanisms of change and their persistence remain unexplored. Here we show that, over the past 1.36 million years, wet winters in the northcentral Mediterranean tend to occur with high contrasts in local, seasonal insolation and a vigorous African summer monsoon. Our proxy time series from Lake Ohrid on the Balkan Peninsula, together with a 784,000-year transient climate model hindcast, suggest that increased sea surface temperatures amplify local cyclone development and refuel North Atlantic low-pressure systems that enter the Mediterranean during phases of low continental ice volume and high concentrations of atmospheric greenhouse gases. A comparison with modern reanalysis data shows that current drivers of the amount of rainfall in the Mediterranean share some similarities to those that drive the reconstructed increases in precipitation. Our data cover multiple insolation maxima and are therefore an important benchmark for testing climate model performance.

Beachrocks are consolidated sedimentary formations and are composed of coastal sediments, which are cemented through the precipitation of carbonates. The lithification takes place in the intertidal zone and can include various sediments, such as sands and gravels of clastic and biogenic origin. This study deals with the cements’ mineralogical and geochemical features of a beachrock outcrop and its aim is the contribution for further understanding on the cementation process of beachrocks. (e.g. Vieira and Ros, 2007; Vousdoukas et al., 2007; Karkani et al., 2017).

Mitochondrial selective autophagy (mitophagy) is a critical cellular process for mitochondrial homeostasis and survival both under basal and stress conditions. Distinct cell types display different requirements for mitochondrial turnover depending on their metabolic status, differentiation state, and environmental cues. This points to the necessity of developing novel tools for real-time, tissue-specific assessment of mitophagy. Caenorhabditis elegans is an invaluable model organism for this kind of analysis providing a platform for simultaneous monitoring of mitophagy in vivo in different tissues and cell types, during development, stress conditions, and/or throughout life span. In this chapter we describe three versatile, noninvasive methods, developed for monitoring in vivo early and late mitophagic events in body wall muscles and neuronal cells of C. elegans. These procedures can be readily used and/or provide insights into the generation of novel imaging methods to investigate further the role of mitophagy at the organismal level under normal and pathological conditions.

Accumulation of damaged mitochondria is a hallmark of aging and age-related neurodegeneration, including Alzheimer's disease (AD). The molecular mechanisms of impaired mitochondrial homeostasis in AD are being investigated. Here we provide evidence that mitophagy is impaired in the hippocampus of AD patients, in induced pluripotent stem cell-derived human AD neurons, and in animal AD models. In both amyloid-beta (Abeta) and tau Caenorhabditis elegans models of AD, mitophagy stimulation (through NAD(+) supplementation, urolithin A, and actinonin) reverses memory impairment through PINK-1 (PTEN-induced kinase-1)-, PDR-1 (Parkinson's disease-related-1; parkin)-, or DCT-1 (DAF-16/FOXO-controlled germline-tumor affecting-1)-dependent pathways. Mitophagy diminishes insoluble Abeta1-42 and Abeta1-40 and prevents cognitive impairment in an APP/PS1 mouse model through microglial phagocytosis of extracellular Abeta plaques and suppression of neuroinflammation. Mitophagy enhancement abolishes AD-related tau hyperphosphorylation in human neuronal cells and reverses memory impairment in transgenic tau nematodes and mice. Our findings suggest that impaired removal of defective mitochondria is a pivotal event in AD pathogenesis and that mitophagy represents a potential therapeutic intervention.

Cfz decreases left ventricular function in mice through increased PP2A activity and inhibition of AMPK$\alpha$/autophagy regulatory axes. Met preserves left ventricular function in mice by restoring AMPK$\alpha$ activation; thus, it emerges as a prophylactic therapy.

In the presented case study, we combined re-mote sensing techniques and lidar technology by using a handheld laser scanner in order to generate a complete 3D model of the Koutouki Cave, at Peania, Greece. Using open – source software we made a quantification anal- ysis of the terrain and generate morphological features of the speleothems with high accuracy and detail in order to estimate the speleogenesis and monitor the evolution of the cave.

The generation of rock cavities and especially of those created under karstic procedures is a matter of research for the last decades. A high-resolution subsurface morphology could be produced after scanning the entire cave with state-of-the-art equipment based on Light Detection And Range technology. A handheld laser scanner was used for acquiring points with projected coordinate information (X,Y,Z) covering the entire show cave of Koutouki (Athens, Greece), including its hidden passages and dark corners. The point cloud covers the floor, the walls and the roof of the cave, as well as the stalactites, stalagmites and the connected columns that constitute the decoration of the cave. The absolute and exact placement of the point cloud within a geographic reference frame gives us the opportunity for three-dimensional measurements and detailed visualization of the subsurface structures.

The aim of this paper is to present and suggest the Most Significant Change as aneffective evaluation methodology of Theatre in Education (TiE) programmes. It is agiven that TiE, as other forms of performative and participatory educational projects,is hard to be assessed and evaluated. It becomes harder due to the lack of adequateresearch in the field and thus the lack of initiatives, data and experience. This paperpresents the “Most Significant Change” (Davies & Dart, 2005) evaluation method asadjusted by the researchers, which was implemented after the TiE programme “StonKosmo tou” (In his world) funded by the Aikaterini Laskaridis Foundation. This isthe first presentation and analysis of a wider study that took place during the schoolyear 2017-2018, where 38 schools, 2185 students and 58 teachers were researchedafter the application of the programme. This paper argues that narratives and storiesmay well serve as an internal process of evaluation of TiE and other educationalparticipatory programmes. It attempts to suggest specific steps of using a well-knownevaluation tool and launch a new approach on the evaluation and assessment of such educational interventions.

RESUMEN: En la novela Cajambre Armando Romero retrata el ambiente socio-cultural del territorio selvático del río Cajambre y reflexiona sobre el modo de vida de sus habitantes. Los personajes femeninos de su obra son complejos e interesantes. La difunta Ruperta, una pobre trabajadora afrocolombiana, es un personaje lleno de misterio, cuya vida amorosa y acción revolucionaria se revela durante el desarrollo de la trama. Por otro lado, otros personajes femeninos como Mar, la joven estudiante de ingeniería forestal, se interesa por las costumbres de la región y el medio ambiente, y Elodia, mujer dinámica y fuerte, se caracteriza por su labor social. El presente trabajo enfoca en el papel determinante del entorno físico y social en la vida de estos personajes para subrayar tanto la explotación de la mujer afrocolombiana como la de la naturaleza. Palabras clave: novela, naturaleza, explotación, personajes, mujer

A multidisciplinary analysis comprising neotectonic mapping, morphotectonic indices, applied geophysics and remote sensing techniques was applied in the area affected by the 2008 NW Peloponnese (Western Greece) in order to map the recently-recognized E-W striking Pineios River normal fault zone with a high degree of accuracy, and to better understand its contribution to the evolution of the ancient region of Elis during Holocene time. Quantitative constraints on deformation caused by the faulting were applied through the application of morphometric and morphotectonic indices including drainage network asymmetry, longitudinal river profiles and valley floor slope changes, the river sinuosity index (SI) of modern channels as well as mountain front indices including mountain front sinuosity (Smf) and percentage of faceting along mountain front (F%). All of the aforementioned indicated that the Pineios fault zone is a highly active structure.

A fluorescence study of N1-(β-D-glucopyranosyl)-N4-[2-acridin-9(10H)-onyl]-cytosine (GLAC), the first fluorescent potent inhibitor of Glycogen Phosphorylase (GP), in neutral aqueous solution, is presented herein. Quantum chemistry (TD-DFT) calculations show the existence of several conformers both in the ground and first excited state. They result from rotation of the acridone and cytosine moieties around an NH bridge which may lead to the formation of non-emitting charge transfer states. The fingerprint of various conformers have been detected by time-resolved fluorescence spectroscopy (fluorescence upconversion and time-correlated single photon counting) and identified using as criteria their energy, polarization and relative population resulting from computations. Such an analysis should contribute to the design of new GP inhibitors with better fluorescence properties, suitable for imaging applications.

The results of Structure-from-Motion techniques in order to quantify the ground surface deformation due to the massive landslide that occurred at the lignite open pit in Amyntaio, Greece on June 10th 2017, are presented in this paper. This unexpected slide damaged the entire westernmost marginal area of the pit, significant number of buildings and infrastructures (incl. road network, powerlines, biological treatment, houses etc.) of the nearby village of Anargiri, as well as agricultural land at the head of the landslide. We generated a very high-resolution surface topography and corresponding co-registered ortho-rectified images covering a total area of 2 km2 by analyzing images acquired from Remotely Piloted Airborne Systems (RPASs). A high resolution (0.13 m) Digital Surface Model (DSM) was produced after photogrammetric processing, serving as a reference dataset for comparison with other surveys realized in December 2017 and September 2018. We compared the centimeter-resolution DSMs acquired during the post landslide periods, quantified the overall ground deformation and finally delineated regions of potential risk.

The development of nanostructured semiconductors with tailored morphology and electronic properties for surface-enhanced Raman scattering (SERS) has been attracting significant attention as a promising alternative to conventional coinage metal SERS substrates. In this work, functionalized TiO2 photonic crystals by graphene oxide nanocolloids (nanoGO) are demonstrated as highly sensitive, recyclable, plasmon-free SERS substrates that combine slow-photon amplification effects with the high adsorption capacity and surface reactivity of GO nanosheets. Comparative evaluation of photonic band gap engineered nanoGO–TiO2 inverse opal films was performed on methylene blue SERS detection under different laser excitations in combination with rigorous theoretical simulations of the photonic band structure. A very low detection limit of 6 × 10−7 M and an enhancement factor of 5 × 104 along with excellent self-cleaning performance and reusability could be achieved by the interplay of slow-photon effects assisted by interfacial charge transfer between the analyte and the nanoGO–TiO2 semiconducting substrate. Slow-photon management in combination with judicious engineering of chemical enhancement in photonic nanostructures is accordingly proposed as an advanced approach for the design of efficient dielectric SERS substrates.

The development of nanostructured semiconductors with tailored morphology and electronic properties for surface-enhanced Raman scattering (SERS) has been attracting significant attention as a promising alternative to conventional coinage metal SERS substrates. In this work, functionalized TiO2 photonic crystals by graphene oxide nanocolloids (nanoGO) are demonstrated as highly sensitive, recyclable, plasmon-free SERS substrates that combine slow-photon amplification effects with the high adsorption capacity and surface reactivity of GO nanosheets. Comparative evaluation of photonic band gap engineered nanoGO-TiO2 inverse opal films was performed on methylene blue SERS detection under different laser excitations in combination with rigorous theoretical simulations of the photonic band structure. A very low detection limit of 6 × 10-7 M and an enhancement factor of 5 × 104 along with excellent self-cleaning performance and reusability could be achieved by the interplay of slow-photon effects assisted by interfacial charge transfer between the analyte and the nanoGO-TiO2 semiconducting substrate. Slow-photon management in combination with judicious engineering of chemical enhancement in photonic nanostructures is accordingly proposed as an advanced approach for the design of efficient dielectric SERS substrates. © 2019 The Royal Society of Chemistry.

The utility of periodic sonographic assessment and monitoring for early diagnosis of deep vein thrombosis (DVT) in patients hospitalized in intensive care units (ICUs) was investigated. Of 314 patients hospitalized in an ICU over a 24-mo period, 248 were examined. The first examination of the patients was carried out within the first 48 h of ICU admission, and weekly examination followed until discharge. Peripheral veins were examined according to the general principles of the ultrasound study using the compression test in B-mode imaging (image to gray scale). The criterion for the absence or presence of a clot within the lumen was the presence or absence of full compressibility of the venous lumen, respectively. Intermittent compression was applied to multiple cross sections along the entire extent of the limbs. Three patients (1.2%) were diagnosed with sub-clinical DVT. The diagnoses were made on the third (sapheno-femoral junction), fourth (right internal jugular) and fifth (left gastrocnemius) weeks of hospitalization, respectively, although patients received full anticoagulation prophylaxis. DVT in a general-population ICU patient on anticoagulation prophylaxis did not seem to occur very frequently, and hence, regular ultrasound monitoring is not recommended. However, it may have value after the third week or in a selected population of ICU patients with very severe and/or multiple predisposing factors or who are not undergoing anticoagulant treatment because of contraindications.

Individuals with recent/acute HIV-infection have an increased likelihood of disease transmission. To evaluate effectiveness of identifying recent infections, we compared networks of recently and long-term HIV-infected individuals. The Transmission Reduction Intervention Project included two separate arms of recruitment, networks of recently HIV-infected individuals and networks of long-term HIV-infected individuals. Networks of each were recruited and tested for HIV and syphilis infection. The per-seed yield ratios of recruitment were compared between arms. Overall, 84 (41.6%) of 202 participants were identified as HIV-positive. HIV prevalence was higher (p < 0.001) among networks of recent seeds (33/96, 34.4%) compared to long-term seeds (6/31, 19.4%). More individuals were identified with active syphilis infection (p = 0.007) among networks of recent seeds (15/96, 15.6%), compared to networks of long-term seeds (3/31, 9.7%). Network-based recruitment of recently HIV-infected individuals was more effective at identifying HIV and syphilis infection. Allocation of public health resources may be improved by targeting interventions toward networks of recently HIV-infected individuals.

Environmental enrichment (EE), comprising positive physical (exercise) and cognitive stimuli, influences neuronal structure and usually improves brain function. The promise of EE as a preventative strategy against neuropsychiatric disease is especially high during early postnatal development when the brain is still amenable to reorganization. Despite the fact that male and female brains differ in terms of connectivity and function that may reflect early life experiences, knowledge of the neural substrates and mechanisms by which such changes arise remains limited. This study compared the impact of EE combined with physical activity on neuroplasticity and its functional consequences in adult male and female rats; EE was provided during the first 3 months of life and our analysis focused on the hippocampus, an area implicated in cognitive behavior as well as the neuroendocrine response to stress. Both male and female rats reared in EE displayed better object recognition memory than their control counterparts. Interestingly, sex differences were revealed in the effects of EE on time spent exploring the objects during this test. Independently of sex, EE increased hippocampal turnover rates of dopamine and serotonin and reduced expression of 5-HT receptors; in addition, EE upregulated expression of synaptophysin, a presynaptic protein, in the hippocampus. As compared to their respective controls, EE-exposed males exhibited parallel increases in phosphorylated Tau and the GluN2B receptor, whereas females responded to EE with reduced hippocampal levels of glutamate and GluN2B. Together, these observations provide further evidence on the differential effects of EE on markers of hippocampal neuroplasticity in males and females.

Environmental enrichment (EE), comprising positive physical (exercise) and cognitive stimuli, influences neuronal structure and usually improves brain function. The promise of EE as a preventative strategy against neuropsychiatric disease is especially high during early postnatal development when the brain is still amenable to reorganization. Despite the fact that male and female brains differ in terms of connectivity and function that may reflect early life experiences, knowledge of the neural substrates and mechanisms by which such changes arise remains limited. This study compared the impact of EE combined with physical activity on neuroplasticity and its functional consequences in adult male and female rats; EE was provided during the first 3 months of life and our analysis focused on the hippocampus, an area implicated in cognitive behavior as well as the neuroendocrine response to stress. Both male and female rats reared in EE displayed better object recognition memory than their control counterparts. Interestingly, sex differences were revealed in the effects of EE on time spent exploring the objects during this test. Independently of sex, EE increased hippocampal turnover rates of dopamine and serotonin and reduced expression of 5-HT(1A) receptors; in addition, EE upregulated expression of synaptophysin, a presynaptic protein, in the hippocampus. As compared to their respective controls, EE-exposed males exhibited parallel increases in phosphorylated Tau and the GluN2B receptor, whereas females responded to EE with reduced hippocampal levels of glutamate and GluN2B. Together, these observations provide further evidence on the differential effects of EE on markers of hippocampal neuroplasticity in males and females.

We present a source catalog from the first deep hard X-ray (E > 10 keV) survey of the Small Magellanic Cloud (SMC), the Nuclear Spectroscopic Telescope Array (NuSTAR) Legacy Survey of the SMC. We observed three fields, for a total exposure time of 1 Ms, along the bar of this nearby star-forming galaxy. Fields were chosen for their young stellar and accreting binary populations. We detected 10 sources above a 3σ significance level (4-25 keV) and obtained upper limits on an additional 40 sources. We reached a 3σ limiting luminosity in the 4-25 keV band of ∼1035 erg s-1, allowing us to probe fainter X-ray binary (XRB) populations than has been possible with other extragalactic NuSTAR surveys. We used hard X-ray colors and luminosities to constrain the compact-object type, exploiting the spectral differences between accreting black holes and neutron stars at E > 10 keV. Several of our sources demonstrate variability consistent with previously observed behavior. We confirmed pulsations for seven pulsars in our 3σ sample. We present the first detection of pulsations from a Be-XRB, SXP 305 (CXO J005215.4-73191), with an X-ray pulse period of 305.69 ± 0.16 s and a likely orbital period of ∼1160-1180 days. Bright sources (≳5 × 1036 erg s-1) in our sample have compact-object classifications consistent with their previously reported types in the literature. Lower-luminosity sources (≲5 × 1036 erg s-1) have X-ray colors and luminosities consistent with multiple classifications. We raise questions about possible spectral differences at low luminosity between SMC pulsars and the Galactic pulsars used to create the diagnostic diagrams.

The gravity method has been applied, with a total of 1.122 gravity measurements for the subsurface investigation of the geotectonic structure beneath the urban and sub-urban areas of Athens basin. The aim was to either verify previously mapped concealed fault zones or even discover new concealed faults that may affect the city in the future by generating disastrous earthquakes. Three different methods have been used to determine the densities of the existing geological formations in the best possible way: laboratory measurements, Nettleton profiles and the seismic velocity conversion. In the context of the qualitative interpretation, we took advantage of the derivatives methods in order to enhance the structural edges of density sources that may reflect fault zones. Thereby, several structural maps have been produced by applying most of the enhancement techniques, such as the Total Horizontal Derivative (THDR), the First Vertical Derivative (VDR), the Second Vertical Derivative (SVDR), the Analytical Signal (AS), Tilt (Tilt) and the Theta (cos Tilt). Their results were extremely helpful, providing severe indications for the delineation of the fault pattern of the area. These results were combined with interpretive geological 2.75-D density models in order to verify or modify fault regime of the area. Important data regarding the geological and tectonic structure beneath the Quaternary formations were retrieved. More specifically, we were able to verify and modify the locations and lengths of already proposed as concealed faults zones from older geological researches or even better to identify and propose new locations of concealed faults that have not been identified so far.

NGC 300 ULX1 is the fourth to be discovered in the class of the ultra-luminous X-ray pulsars. Pulsations from NGC 300 ULX1 were discovered during simultaneous XMM-Newton / NuSTAR observations in Dec. 2016. The period decreased from 31.71 s to 31.54 s within a few days, with a spin-up rate of -5.56×10-7 s s-1, likely one of the largest ever observed from an accreting neutron star. Archival Swift and NICER observations revealed that the period decreased exponentially from 45 s to 17.5 s over 2.3 years. The pulses are highly modulated with a pulsed fraction strongly increasing with energy and reaching nearly 80% at energies above 10 keV. The X-ray spectrum is described by a power-law and a disk black-body model, leading to a 0.3-30 keV unabsorbed luminosity of 4.7×1039 erg s-1. The spectrum from an archival XMM-Newton observation of 2010 can be explained by the same model, however, with much higher absorption. This suggests, that the intrinsic luminosity did not change much since that epoch. NGC 300 ULX1 shares many properties with supergiant high mass X-ray binaries, however, at an extreme accretion rate.

NGC 300 ULX1 is an ultraluminous X-ray pulsar, showing an unprecedented spin evolution, from about 126 s to less than 20 s in only 4 yr, consistent with steady mass accretion rate. Following its discovery we have been monitoring the system with Swift and NICER to further study its properties. We found that even though the observed flux of the system dropped by a factor of ≳20, the spin-up rate remained almost constant. A possible explanation is that the decrease in the observed flux is a result of increased absorption of obscuring material due to outflows or a precessing accretion disc.

Ultra luminous X-ray Pulsars (ULXPs) are bright binary systems that host a Neutron Star (NS) and emit radiation in excess of the Eddington Limit expected for isotropic accretion. We have studies the spectral and spin properties of the ULXP NGC300 ULX1 through archival data, and have shown that its spin evolution from ~126 s down to 16 s is consistent with almost constant accretion between 2014 and 2018. Moreover, based on the 2018 Swift/XRT and NICER monitoring campaigns of the system we have concluded that even during an 100 d period where the observed flux drops by a factor of 20, the spin-up rate and thus the mass accretion rate remained almost constant. This can be explained only by invoking extreme X-ray absorption or obscuration due to extreme outflows from the accretion disk, or disk precession. Finally, an intriguing consequence is that assuming constant spin-up rate a NS spin reversal should have occurred around 2012.

MAXI J0206-749 is a hard X-ray transient detected by MAXI/GSC (ATel #13300) in the direction of the Small Magellanic Cloud (SMC) wing. Follow-up Swift/XRT observations (ATel #13303) identified MAXI J0206-749 with the HMXB RX J0209.6-7427.

Multiple myeloma (MM) is a haematological malignancy being characterized by clonal plasma cell proliferation in the bone marrow. Targeting the proteasome with specific inhibitors (PIs) has been proven a promising therapeutic strategy and PIs have been approved for the treatment of MM and mantle-cell lymphoma; yet, while outcome has improved, most patients inevitably relapse. As relapse refers to MM cells that survive therapy, we sought to identify the molecular responses induced in MM cells after non-lethal proteasome inhibition. By using bortezomib (BTZ), epoxomicin (EPOX; a carfilzomib-like PI) and three PIs, namely Rub999, PR671A and Rub1024 that target each of the three proteasome peptidases, we found that only BTZ and EPOX are toxic in MM cells at low concentrations. Phosphoproteomic profiling after treatment of MM cells with non-lethal (IC10) doses of the PIs revealed inhibitor- and cell type-specific readouts, being marked by the activation of tumorigenic STAT3 and STAT6. Consistently, cytokine/chemokine profiling revealed the increased secretion of immunosuppressive pro-tumorigenic cytokines (IL6 and IL8), along with the inhibition of potent T cell chemoattractant chemokines (CXCL10). These findings indicate that MM cells that survive treatment with therapeutic PIs shape a pro-tumorigenic immunosuppressive cellular and secretory bone marrow microenvironment that enables malignancy to relapse.

Extracellular matrix (ECM) macromolecules, apart from structural role for the surrounding tissue, have also been defined as crucial mediators in several cell mechanisms. The proteolytic and cross-linking cascades of ECM have fundamental importance in health and disease, which is increasingly becoming acknowledged. However, formidable challenges remain to identify the diverse and novel role of ECM molecules, especially with regard to their distinct biophysical, biochemical, and structural properties. Considering the heterogeneous, dynamic, and hierarchical nature of ECM, the characterization of 3D functional molecular view of ECM in atomic detail will be very useful for further ECM-related studies. Nowadays, the creation of a pioneer ECM multidisciplinary integrated platform in order to decipher ECM homeostasis is more possible than ever. The access to cutting-edge technologies, such as optical imaging and electron and atomic force microscopies, along with diffraction and X-ray-based spectroscopic methods can integrate spanning wide ranges of spatial and time resolutions. Subsequently, ECM image-guided site-directed proteomics can reveal molecular compositions in defined native and reconstituted ECM microenvironments. In addition, the use of highly selective ECM enzyme inhibitors enables the comparative molecular analyses within pre-classified remodeled ECM microenvironments. Mechanistic information which will be derived can be used to develop novel protein-based inhibitors for effective diagnostic and/or therapeutic modalities targeting ECM reactions within tissue microenvironment.

Aging is a complex phenomenon caused by the time-dependent loss of cellular homeodynamics and consequently of physiological organismal functions. This process is affected by both genetic and environmental (e.g., diet) factors, as well as by their constant interaction. Consistently, deregulation of nutrient sensing and signaling pathways is considered a hallmark of aging. Nutrigenomics is an emerging scientific discipline that studies changes induced by diet on the genome and thus it considers the intersection of three topics, namely health, diet, and genomics. Model organisms, such as the fruit fly Drosophila melanogaster, have been successfully used for in vivo modeling of higher metazoans aging and for nutrigenomic studies. Drosophila is a well-studied organism with sophisticated genetics and a fully annotated sequenced genome, in which {\~{}} 75{%} of human disease-related genes have functional orthologs. Also, flies have organs/tissues that perform the equivalent functions of most mammalian organs, while discrete clusters of cells maintain insect carbohydrate homeostasis in a way similar to pancreatic cells. Herein, we discuss the mechanistic connections between nutrition and aging in Drosophila, and how this model organism can be used to study the effect of different diets (including natural products and/or their derivatives) on higher metazoans longevity.

A variety of remote sensing tools have been extensively used in the past years for landslide detection and mapping purposes. In addition, detection and mapping of landslide and rockfall events using remote sensing products has been proved to be an effective approach to provide landslide inventories (Scaioni et al., 2014). However, most of the studies are lacking valuable semantic information about landslide elements and how they react with the surrounding environment; natural and man-made primitives. In addition, post classification object-based approaches have been proved to result in better accuracies compared with the pixel-based (Martha et al., 2011). Lately, innovative close-range remote sensing technology such as Unmanned Aerial Vehicle (UAV) photogrammetry and Terrestrial Laser Scanning (TLS) are widely applied in the field of geoscience due to their efficiency in collecting data about terrain morphology rapidly. Their main advantage stands on the fact that conventional methods are mainly collecting point measurements such as compass measurements of bedding and fracture orientation only from areas that were accessible. Aerial platforms are capable to overcome technical issues such as potential occlusions and unfavorable incidence angles due to their ability to capture imagery from multiple positions and with different angles. Nowadays, UAVs tend to be more flexible and powerful tools for landslide and rockfall investigations compared to TLS, due to their low-cost and ease of transportability in harsh environments but also with technology advances such as maintaining of Real Time Kinematic (RTK) positioning. An important factor of their usefulness is their capability to offer unprecedented spatial resolution over wide inaccessible areas, maintain a variability of different sensors (optical, laser, thermal, multispectral) and great ability to reach remote areas and acquire data as close as the user defines. UAVs applications are widely used in post-disaster situations for emergency support, in infrastructure monitoring, in natural resources management, in geohazard monitoring etc. (Corominas et al., 2016; Vassilakis et al., 2019). The latter proves that UAV market has been rapidly growing over the last decade and in future more applications will be introduced in the public. Thus, rapidness and efficiency of Structure-from-Motion (SfM) technology in landslide management provides numerous advantages such as creating landslide inventory maps providing 3D information of large areas.

Detection and mapping of landslide and rockfall events using remote sensing products has been proved to be an effective approach to provide landslide inventories. However, most of the studies are lacking valuable semantic information about landslide elements and how they react with the surrounding environment; natural and man-made primitives. In addition, post classification object-based approaches have been proved to result in better accuracy compared with the pixel-based. Lately, innovative close-range remote sensing technology such as Unmanned Aerial Vehicle (UAV) photogrammetry and Terrestrial Laser Scanning (TLS) are widely applied in the field of geoscience due to their efficiency in collecting data about terrain morphology rapidly. This research aims to demonstrate the applicability of UAV technology for automated semantic labeling in managing landslide and rockfall hazard in mountainous environments during emergency situations. SfM photogrammetry in addition to high accuracy RTK-GNSS ground control point establishment, is used to provide detailed 3D point clouds describing the surface morphology of the landslide and rockfall elements. The proposed methodology was divided in five main working phases. The first phase includes designing and execution of an optimal UAV flight planning to collect accurate 3D data. During the second phase, the pre-processing and raw data preparation such as point cloud filtering and elimination of ambiguities is taking place, while at the next phase an image segmentation using the 3D point cloud RGB information is created. The main task was focused on identifying the specific landslide elements by using an object-based approach. Based on Object-Based Image Analysis (OBIA), a sequence of image-based processes was applied, including multi-scale object segmentation, spectral, morphometric and contextual information extraction aiming to detect the landslide among other features. The next phase was set up for object classification in meaningful and homogeneous landslide classes (e.g. scarp, depletion zone, accumulation zone) which are spatially connected by introducing contextual information in the ruleset. The proposed methodology presents the effectiveness and efficiency of UAV platforms to acquire accurate photogrammetric datasets from intense relief environments and complex surface topographies by providing a holistic assessment and characterization of the failure site based on semantic classification of the landslide and rockfall objects. Results have demonstrated the capabilities of combining UAV platforms with computer-based methods for rapid and accurate identification of valuable semantic information subjectively and even from inaccessible areas of the landslide and rockfall body.