Publications

Objective: We evaluated safety and efficacy of first-line gemcitabine/carboplatin in unfit-for-cisplatin patients with advanced urothelial carcinoma and the effect on the quality of life and functional status of elderly patients (aged >70). Methods: Unfit patients had ECOG performance status (PS) ≥2, creatinine clearance <50 ml/min or comorbidities precluding cisplatin administration. Carboplatin at area under the curve of 2.5 and gemcitabine 1,250 mg/m2 were administered biweekly. Elderly patients were stratified into group 1 (no activities of daily living (ADL) or instrumental ADL dependency and no comorbidities), group 2 (instrumental ADL dependency or 1-2 comorbidities) and group 3 (ADL dependency or ≥2 comorbidities). Results: Thirty-four patients were enrolled: 68% had PS 2-3, 69% a creatinine clearance <50 ml/min and 65% had 1 or more comorbidities. There were 3 cases of grade 3 toxicity (9%). Response rate was 24% [95% confidence interval (CI) 11-41]. Median follow-up was 8 months, median progression-free survival 4.4 months (95% CI 1.03-7.75) and median overall survival 9.8 months (95% CI 4.7-14.9). Patients in geriatric assessment groups 1 and 2 had a significantly longer median progression-free survival compared to group 3 [6.9 months (95% CI 1.3-12.4) vs. 1.9 months (95% CI 0.5-3.2); p = 0.005]. Conclusion: First-line gemcitabine/carboplatin combination is active in unfit-for-cisplatin patients with advanced urothelial carcinoma. Pretreatment quality of life and geriatric assessment may be useful in selecting patients likely to benefit from this treatment. Copyright © 2008 S. Karger AG.

Objectives: Synergism between gemcitabine and cisplatin is supported by preclinical and clinical data. The present study explores the efficacy of a biweekly regimen in platinum-resistant/refractory, paclitaxel-pretreated ovarian and peritoneal cancer. Methods: 50 paclitaxel-pretreated patients with platinum-resistant/refractory ovarian or peritoneal carcinoma who had previously received paclitaxel chemotherapy, were treated with six cycles of gemcitabine 1000 mg/m2 followed by cisplatin 40 mg/m2 on days 1 and 15, repeated every 4 weeks. Results: The median platinum-free interval (PFI) was 4 months while the median number of previous treatment lines was 2. Chemotherapy was well tolerated. Objective responses were observed in 31.5% of evaluable patients (n = 35). CA125 response was observed in 68% of patients with elevated CA125 (n = 41). Median overall survival (OS) was 13.2 months (95% Confidence Interval, CI: 10.2-16.2) while progression-free survival (PFS) was 4.9 months (95%CI: 3.5-6.4). A PFI of less than 3 months was associated with lower objective response rates (15.8% versus 50%, p = 0.03). Conclusions: Biweekly gemcitabine and cisplatin is feasible for patients with platinum-resistant ovarian or peritoneal cancer and is associated with a favorable toxicity profile. In a population with recent exposure to platinum, a PFI of less than 3 months was the major factor influencing response to chemotherapy. © 2007 Elsevier Inc. All rights reserved.

Aim. This study examined the ventilatory responses and blood lactate concentration after a simulated synchronized swimming routine of athletes of two different age categories. Methods. Sixteen trained female synchronized swimmers, 8 competing at the comen category (age: 13.8±0.2 years) and 8 competing at the senior category (age: 22.6±0.9 years), performed a maximal 400 m swimming test and a simulated synchronized swimming routine. Oxygen uptake (V̇O2) of the tests was obtained by backward extrapolation of a monoexponential curve fitted to the postexercise oxygen uptake data. Results. There were no differences in V̇O2 at the end of the routine (37.4±2.7 vs 40.5±2 mL·kg -1·min-1, or 81.8±3.1% and 85.8±2.7% of V̇O2peak) and blood lactate (5.7*0.9 vs 4.5±0.4 mmol-L-1) between senior and comen synchronized swimmers. There was no difference in the half-time of V̇O2 decay (T1/2) between the athletes of the two categories, but T1/2 was significantly higher after the routine compared with the V̇O2peak test for both categories (senior: 45.2±5.9 vs 33.1±2.1 s, P<0.05, comen: 38.2±6 vs 27.4±8.2 s, P<0.05). The mean end-tidal pressure of CO2 during the second half of the recovery was higher after the routine than after the V̇O2peak test (37.2±1.4 vs 34.5±1.5 mmHg, P<0.05), possibly due to the prolonged periods of breath holding (55±4% of routine time). Breathing frequency was also high (30±2.2 breaths.min-1) at the later part of recovery after the routine. Conclusion. Cardiorespiratory and metabolic responses to a simulated synchronized swimming routine were similar in senior and comen athletes. The slower recovery of V̇O2 after the routine could be related to the elevated cost of ventilation, especially during the later stages of recovery, possibly as a result of the prolonged apnea.

Aim. This study examined the ventilatory responses and blood lactate concentration after a simulated synchronized swimming routine of athletes of two different age categories. Methods. Sixteen trained female synchronized swimmers, 8 competing at the comen category (age: 13.8±0.2 years) and 8 competing at the senior category (age: 22.6±0.9 years), performed a maximal 400 m swimming test and a simulated synchronized swimming routine. Oxygen uptake (V̇O2) of the tests was obtained by backward extrapolation of a monoexponential curve fitted to the postexercise oxygen uptake data. Results. There were no differences in V̇O2 at the end of the routine (37.4±2.7 vs 40.5±2 mL·kg -1·min-1, or 81.8±3.1% and 85.8±2.7% of V̇O2peak) and blood lactate (5.7*0.9 vs 4.5±0.4 mmol-L-1) between senior and comen synchronized swimmers. There was no difference in the half-time of V̇O2 decay (T1/2) between the athletes of the two categories, but T1/2 was significantly higher after the routine compared with the V̇O2peak test for both categories (senior: 45.2±5.9 vs 33.1±2.1 s, P<0.05, comen: 38.2±6 vs 27.4±8.2 s, P<0.05). The mean end-tidal pressure of CO2 during the second half of the recovery was higher after the routine than after the V̇O2peak test (37.2±1.4 vs 34.5±1.5 mmHg, P<0.05), possibly due to the prolonged periods of breath holding (55±4% of routine time). Breathing frequency was also high (30±2.2 breaths.min-1) at the later part of recovery after the routine. Conclusion. Cardiorespiratory and metabolic responses to a simulated synchronized swimming routine were similar in senior and comen athletes. The slower recovery of V̇O2 after the routine could be related to the elevated cost of ventilation, especially during the later stages of recovery, possibly as a result of the prolonged apnea.

Aim. This study examined the ventilatory responses and blood lactate concentration after a simulated synchronized swimming routine of athletes of two different age categories. Methods. Sixteen trained female synchronized swimmers, 8 competing at the comen category (age: 13.8±0.2 years) and 8 competing at the senior category (age: 22.6±0.9 years), performed a maximal 400 m swimming test and a simulated synchronized swimming routine. Oxygen uptake (V̇O2) of the tests was obtained by backward extrapolation of a monoexponential curve fitted to the postexercise oxygen uptake data. Results. There were no differences in V̇O2 at the end of the routine (37.4±2.7 vs 40.5±2 mL·kg -1·min-1, or 81.8±3.1% and 85.8±2.7% of V̇O2peak) and blood lactate (5.7*0.9 vs 4.5±0.4 mmol-L-1) between senior and comen synchronized swimmers. There was no difference in the half-time of V̇O2 decay (T1/2) between the athletes of the two categories, but T1/2 was significantly higher after the routine compared with the V̇O2peak test for both categories (senior: 45.2±5.9 vs 33.1±2.1 s, P<0.05, comen: 38.2±6 vs 27.4±8.2 s, P<0.05). The mean end-tidal pressure of CO2 during the second half of the recovery was higher after the routine than after the V̇O2peak test (37.2±1.4 vs 34.5±1.5 mmHg, P<0.05), possibly due to the prolonged periods of breath holding (55±4% of routine time). Breathing frequency was also high (30±2.2 breaths.min-1) at the later part of recovery after the routine. Conclusion. Cardiorespiratory and metabolic responses to a simulated synchronized swimming routine were similar in senior and comen athletes. The slower recovery of V̇O2 after the routine could be related to the elevated cost of ventilation, especially during the later stages of recovery, possibly as a result of the prolonged apnea.

Human rhinoviruses (RVs) are responsible for the majority of upper respiratory tract infections. Despite the high prevalence, the pathogenesis is incompletely understood. Experimental models would permit study of the immunological response to infections. Animal models have many limitations because of the anatomic and physiological differences between mammalian species. The only nonhuman animals susceptible to RV are chimpanzees and gibbons. Mouse models are not used because of host cell tropism of RV. This problem may have been partially overcome by transfecting mouse cells with viral RNA, by replacing mouse ICAM-1 with the human counterpart and by using a variant virus. It remains to be seen if these advances will translate into establishment of useful mouse models. In the absence of animal models, epithelial cell lines such as BEAS-2B, A549, 16HBE and HEp-2 have been used. Fibroblasts and smooth muscle cells have also been used. Although transformed cell lines have many properties in common with normal epithelial cells, they lose certain differentiated functions. Therefore, primary and recently well-differentiated cultures are used to study the immune response. In addition to a local inflammatory response, a systemic immune response to RV does develop; therefore peripheral blood mononuclear cells and dendritic cells have been infected with RV, shedding additional light on cell-mediated immunity. Cellular models are invaluable investigational tools for understanding mechanisms of RV-induced asthma and evaluating new targets for therapy.

Background: In this study we investigated whether administering CEOP (cyclophosphamide, epirubicin, vincristine [Oncovin], and prednisone) every 2 weeks (CEOP-14) instead of every 3 weeks (the standard CEOP-21 regimen) improves outcomes in patients with previously untreated aggressive lymphomas. In a secondary analysis we evaluated the impact of adding rituximab to CEOP-14/CEOP-21 chemotherapy. Study Design: The trial opened in March 1999, and patients were randomly assigned to either CEOP-14 or CEOP-21. All patients enrolled from May 2002 onward received rituximab with each chemotherapy cycle, and those attaining a complete response received rituximab consolidation. Results: Complete and overall response rates in the CEOP-21 ± rituximab (N ≤ 114) and CEOP-14 ± rituximab (N ≤ 103) arms were similar, as were the overall survival (P ≤ 0.769) and time to progression distributions (P ≤ 0.969). Rituximab was shown to have a beneficial effect both on the overall survival and on the time to progression. Conclusions: Thus far, no significant improvement in outcome has been demonstrated with CEOP-14 ± rituximab versus CEOP-21 ± rituximab. However, with addition of rituximab to CEOP-21/CEOP-14, significant improvements in time to progression and overall survival were achieved. © 2007 by Lippincott Williams & Wilkins.

The purpose of this study was to use quantitative methods to measure the size and shape of the sella turcica and thus establish normative reference standards that could assist in a more objective evaluation and detection of pathological conditions. Standardized lateral cephalograms of 184 healthy Greeks (91 males and 93 females) were used. The age range was between 6 and 17 years. Conventional measurements included three different heights of the sella turcica (anterior, posterior, median), its length, and width, measured in relation to the Frankfort reference line. In addition, the area of sella turcica was calculated. Morphometric methods were used to assess shape. The tracings were superimposed using the Procrustes method, and the average shape was computed. Principal component analysis (PCA) was used to assess shape variability. The data were correlated with centroid size, age, and gender. Unpaired t-tests were used to determine gender differences. Sella height anteriorly was the only variable found to be significantly different between the genders, being larger in females by 0.5 mm. Linear and area measurements were found to be significantly correlated with age, but all correlations were low (r(2) below 8 per cent). Sella turcica shape, as described by PCA, was different between males and females, mainly at the posterior aspect of the sella outline. However, although there was an extensive overlap between the genders, and differences were minimal. Age was not found to be correlated with the shape coefficients, although, in the female group, the first principal component of shape was marginally not significant. Allometry was observed in both genders, the sella showing a tendency towards a flatter and wider shape with increase in size. The results of this study constitute quantitative reference data that could be used for objective evaluation of sella shape.

We discuss the results from the optical study of the X-ray sources detected in our Chandra survey of the central region of the Small Magellanic Cloud. Based on the OGLE-II and MCPS optical photometric catalogs we propose the most likely counterpart for 113 X-ray sources, 32 of which are identified with early type counterparts (of OB spectral type based on their position in color-magnitude diagrams). Optical spectroscopy of these counterparts with the 2dF spectrograph (AAT) reveals 13 new Be-XRBs in the SMC "bar". We estimate that these Be-XRBs have an age of 15-85 Myr, consistent with the typical age of Be stars. We also examine the "overabudance" of Be-XRBs in the SMC fields covered by Chandra, in comparison to the Milky Way, and we show that there is residual excess, even after accounting for the higher star formation rate of the SMC. This excess can be attributed to the lower metallicity of the SMC. Finally, we present a preliminary study of the parent stellar populations of these X-ray binaries based on deep IMACS observations. This work was supported by NASA LTSA grant NAG5-13056, and NASA grant G02-3117X.

The present work describes the interfacial polymerization of aniline in the absence or presence of surfactants. Polyaniline was readily obtained in the semi-oxidized doped state and was cast from the aqueous phase. The structural and morphological characteristics of the polyanilines were deduced from X-ray Diffractometry and Scanning Electron Microscopy. Various morphologies were obtained depending on the surfactant addition. Conductivity measurements recorded for HCl doped polyaniline nanoneedles from 5 to 330 K showed a T, value at 230 K, where their transport behaviour changes from metallic-like above T, to semiconductive below T,. Furthermore, extensive magnetic measurements have been performed as a function of applied field and temperature. (c) 2007 Elsevier Ltd. All rights reserved.

The goal of this study is to determine the chemical composition of rain, in the wider region of Athens, Greece for the time period 1st September 2001 to 31st August 2002. Two model automatic rain samplers were installed in the Meteorological Station of Laboratory of Climatology (latitude: 37Β° 58β€² N, longitude: 23Β° 47β€² E) inside the Athens University Campus and in a site at Heraklio Attica, a northern suburb of Athens (latitude: 38Β° 03β€² N, longitude: 23Β° 45β€² E). The concentrations (ΞΌeq l -1) of the major cations (H +, Na +, K +, Ca 2+ and Mg 2+) and anions (Cl -, NO 3 -, HCO 3 - ΞΊΞ±ΞΉ SO 4 2-, as well as pH and conductivity of rain in 39 total samples were determined. The figures of pH range from 6.4 to 8.4 and conductivity from 8 to 207 ΞΌS cm -1. The analysis showed that Ca 2+ ions are abundant within all examined samples, while HCO 3 - and SO 4 2- present the highest concentrations from the anions. In order to find out the origin of the air masses, the air mass back trajectories were calculated. Five sectors of the origin of air masses were revealed: the North, the South, the Local, the West and the East sector. Multivariate methods included Factor Analysis and Discriminant Analysis were applied to the examined ion concentrations and three main factors were extracted, which discriminated the ions according to their origin. The first group of ions is interpreted as the result of the anthropogenic activity, the second group represents the acidity-alkalinity independently of their source and the third one the marine influence. Β© 2007 Springer Science+Business Media B.V.

OBJECTIVE: Adiponectin plays a protective role in several malignancies, including myeloblastic leukemia, whereas leptin may increase the proliferation of progenitor cells and may stimulate leukemic cell growth in vitro. We investigated the role of adiponectin and leptin levels in the etiopathogenesis of myelodysplastic syndromes (MDS), a preleukemic condition with increasing incidence which has recently been associated with obesity. METHODS: In a case-control study, 101 cases with incident, histologically confirmed primary MDS and 101 controls matched on gender and age were studied between 2004 and 2007, and blood samples were collected. RESULTS: Higher serum adiponectin levels were associated with lower risk of MDS by bivariate analysis and after adjusting for age, gender, body mass index and serum levels of leptin (p < 0.001). Subjects in the third quartile for leptin levels had a lower risk of MDS than controls, and low leptin concentrations were observed in low-risk MDS patients with normal or good prognostic karyotype after adjusting for age, gender and body mass index. CONCLUSIONS: Circulating adiponectin and leptin may play an important role in MDS etiopathogenesis. Future studies are needed to confirm these associations and to explore underlying mechanisms.

{OBJECTIVE: To determine circulating levels of adiponectin in preterm infants and examine possible associations with anthropometric measurements, weight gain, and leptin and insulin levels. DESIGN: Prospective study. SETTING: A university hospital neonatal care unit. Study population: 62 preterm (mean (SD) gestational age 32.0 (2.1) weeks) and 15 full-term infants (reference group). INTERVENTIONS: Blood samples taken at discharge (40.9 (14.8) days of life) from the preterm infants and at a comparable postnatal age in full-term infants. All infants were fed the same commercial formula, but in nine preterms the formula contained long-chain polyunsaturated fatty acids (LCPUFAs). MAIN OUTCOME MEASURES: Serum levels of adiponectin, leptin and insulin. Associations of adiponectin levels were tested only in the preterm group. RESULTS: Serum levels of adiponectin were lower in preterm (40.9 (14.8) microg/ml) than full-term infants (53.1 (16.0) microg/ml, p<0.01). However, after adjustment for body weight, the influence of prematurity on adiponectin levels was no longer significant. In preterm infants, adiponectin levels independently correlated with being born small for gestational age (SGA) (beta=-0.35

1. Καμπερίδου, Ε. (2007). Ένα είδος Φυλετικού Διαχωρισμού» (Pardoe, 1837) στους υποτελείς λαούς της Οθωμανικής Αυτοκρατορίας: οι επιβαλλόμενες φυλετικο-χρωματικές διακρίσεις στις οικίες, στα ενδύματα και στα υποδήματα των υποτελών λαών. Φιλοσοφία & Παιδεία, 44-45, 22-25.  J.4 in APELLA

• Kamberidou, I. (2007). Colour Segregation according to race in Ottoman Society. Philosophy & Education (EKDEF), issue, 44-45, Nov.-Dec. 2007,  pp. 22–25.  J.4 in APELLA

Objective: The purpose of this study was to evaluate the efficacy and toxicity of cisplatin, etoposide and irinotecan as first-line treatment in patients with extensive small-cell lung cancer (E-SCLC). Patients and methods: Chemo-naïve adult patients with a performance status (PS) of 0-2 and adequate organ function were eligible. Patients received cisplatin 20 mg/m2 i.v. daily for three consecutive days, etoposide 75 mg/m2 i.v. daily for three consecutive days and irinotecan 120 mg/m2 i.v. on day 2, every 21 days for six to eight cycles. Administration of G-CSF was given in the presence of febrile neutropenia and as a 5-day prophylaxis around the recorded nadir day in patients who developed grades 3-4 neutropenia. Results: Fifty-six patients were assessable. The median age was 62.2 years; 96.4% had PS 0-1, 33.5% had >3 metastatic sites. The overall response rate was 80.4% with 8 (14.3%) patients achieving a complete response. The median time to tumor progression was 7.8 months [95% confidence interval (CI), 7.1-8.6 months] with a median survival of 15.1 months [95% CI, 9.7-20.5 months] and 1-year survival rate of 56.5%. One patient died from toxicity. Grades 3-4 neutropenia occurred in 37.5% of patients, grades 3-4 thrombocytopenia occurred in 10.9% of patients and 11 (19.6%) patients developed febrile neutropenia. Grades 3-4 non-hematological toxicities were primarily nausea-vomiting 3.6%, diarrhea 7.1% and fatigue 3.6%. Conclusion: This study strongly suggests that cisplatin, etoposide and irinotecan combination is very effective for the treatment of E-SCLC with good safety profile. The triplet regimen currently seems a promising regimen and has to be further explored in phase III trials. © 2007 Elsevier Ireland Ltd. All rights reserved.

Concurrent chemoradiotherapy has become a standard therapy for locoregionally advanced inoperable non-small cell lung cancer (NSCLC). The purpose of this phase II trial was to evaluate the efficacy and toxicity of concurrent chemoradiotherapy following induction with non-platinum chemotherapy in patients with inoperable locally advanced NSCLC. Patients and Methods: All patients with locally advanced inoperable NSCLC ECOG performance status (PS): 0-1 following staging received paclitaxel 200 mg/m2 in a 3-h infusion on day 1 and gemcitabine 1000 mg/m2 on days 1 and 8 every 21 days for two cycles. The patients with a response or stable disease (SD) continued to receive paclitaxel 60 mg/m2 weekly and radiotherapy 63 Gy given at 1.8 Gy once a day for 7 weeks. Results: Forty-three eligible patients entered the study. The median age was 63 years (range 42-76), male 93%, IIIB 63% and IIIA 37%. Following induction 15 (36.5%) of the patients responded: complete response (CR), 2%; partial response (PR), 33%; and 19 (46.5%) SD. From those with SD, 7 (37%) improved to a PR following concurrent chemoradiotherapy. With a median follow-up of 44 months (95% CI: range 36-53) the median survival was 20.8 months (95%c CI: range 15.4-26.3) and time-to-progression 8.4 months (95% CI: range 6.2-10.6). The median survival of those who had improved response from SD to PR was 31.4 months (95% CI: range 18.7-44.1) versus 20.8 months (95% CI: range 5.5-11.3) for those who had no improvement (p=0.20). The commonest grade 3/4 toxicity in induction was neutropenia 12% with 2 febrile neutropenic patients whereas in the concurrent chemoradiotherapy neutropenia, neurotoxicity and oesophagitis were observed in 6% of the patients. Conclusion: Concurrent chemoradiotherapy following induction chemotherapy in patients with stage III NSCLC is feasible with reasonable efficacy and acceptable toxicity.

Most recent molecular studies revealed the phylogeny of Greek Podarcis species, which for years remained elusive, due to discordant data produced from various chromosomal, complement fixation and protein studies. In this report, we analyzed cellular immune responses of spleen derived lymphocytes from six allopatric Podarcis species encountered in Greece, by assessing two-way mixed lymphocyte reaction (MLR)-induced proliferation. On the basis of stimulation indices (S.I.) as determined from cultures set up from xenogeneic splenocytes coincubated in pairs, we generated a phylogenetic tree, fully consistent with the phylogenetic relationships of Podarcis as determined by parallel analyses basedon partial mitochondrial (mt) DNA sequences. Although the exact mechanisms triggering lymphocyte responses in lizard two-way xenogeneic MLR are not fully understood, our results show the potential use of cell-mediated immune responses as an additional approach to mtDNA analysis, for species delimitation within specific lizard taxa.

During the period 2004 to 2005, the following symposia and colloquia were related to the activities of the commission: The A-Star Puzzle (IAUS224), Massive Star Birth: A Crossroads of Astrophysics (IAUS227), and From Lithium to Uranium: Elemental Tracers of Early Cosmic Evolution (IAUS228).

The Commission business meeting was held on 17 August 2006. Approximately 20 people attended, including the Commission vice-president, Rainer Spurzem. The sole member of the Commission Organizing Committee that was present was Gary Da Costa, who, along with Patricia Whitelock, the outgoing president of Division VII and Commission 33, served as chairs of the meeting.

A study on the Mizoroki-Heck coupling of selected aryl bromides with acrylates catalysed by a series of Pd complexes of bidentate pyridyl-, picolyl-, diphenylphosphinoethyl- and diphenylphosphinomethyl-functionalised N-heterocyclic carbene (NHC) is reported. The observed activity is dependent on the type of solvent and base used and the nature of the "classical" donors of the mixed-donor bidentate ligand and its bite angle. A mechanistic model is presented for the pyridine-functionalised NHC complexes based on an in situ EXAFS study under dilute catalyst conditions (2 mM Pd). The model involves pre-dissociation of the pyridine functionality and oxidative addition of ArBr in the early stages of the reaction, as well as formation of monomeric and dimeric Pd species at the time of substrate conversion. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

We study the effects of disruption risk in a supply chain where one retailer deals with competing risky suppliers who may default during their production lead times. The suppliers, who compete for business with the retailer by setting wholesale prices, are leaders in a Stackelberg game with the retailer. The retailer, facing uncertain future demand, chooses order quantities while weighing the benefits of procuring from the cheapest supplier against the advantages of order diversification. For the model with two suppliers, we show that low supplier default correlations dampen competition among the suppliers, increasing the equilibrium wholesale prices. Therefore the retailer prefers suppliers with highly correlated default events, despite the loss of diversification benefits. In contrast, the suppliers and the channel prefer defaults that are negatively correlated. However, as the number of suppliers increases, our model predicts that the retailer may be able to take advantage of both competition and diversification. © 2007 INFORMS.

The scope of the present research is to examine the spatial consequences of the predicted future sea-level rise upon the active area of the delta of the River Acheloos, which forms part of the NW coast of the Gulf of Patras (Ionian Sea). The growth of the Acheloos River deltaic plain, prior to the construction of dams and channelization of the lower part of the river, took place through the progradation of four main distributaries which transported 5-6 million tones of sediments annually.Following the construction of the dams, the hydraulic regime of Acheloos has changed and its propagation has ceased. The present investigation aims to quantify coastal changes on the deltaic plain of the Acheloos river due to the combined effect of (i) the process of inundation induced by a future sea level rise of 0.5 and 1 m and (ii) coastal erosion caused by the increased exposure to wave action due to sea-level rise and subsequent coastline retreat. The results of our analysis show severe shoreline recession (up to 1900m), extensive submergence of the active deltaic plain (~ 2586⋅103 m2 or 61.4 %) and elimination of most of the lagoonal areas. The substantial loss of deltaic land, accompanied by salinisation of the groundwater table, will cause severe damage to the agricultural economy of the area. Furthermore, we show that the consequences of a future sea-level rise on a low-relief fluviallydominated delta cannot be predicted accurately by simple conceptual models; instead, a holistic approach incorporating topographic, geomorphological, sedimentological, morphodynamic and hydrodynamic analyses is required.

In the current paper are presented the results of a multidisciplinary study (stratigraphical, sedimentological, geophysical and geochemical) combined with modern techniques (G.I.S. and remote sensing). This study aims at integrating the natural and anthropogenic factors affecting the Korissia lagoon. It is a shallow coastal lagoon, communicating with the sea via an artificial channel. The area around the lagoon consists of alluvial sediments hosting, in places, newly formed and/or “old” (pre – Holocene) sand-dunes. The broader area constitutes a post- alpine sedimentary basin characterised by smooth morphological relief. The lower stratigraphic unit of the post-alpine sequence is a Pleistocene marly formation, which was detected as the basement (5-15 hm.m) by the geophysical survey. The resistivity-based basement map implies the existence of a “palaeo-gulf” trending E- W. These marls constitute the impermeable basement of a shallow aquifer hosted in the area. The salinity of the lagoon is very high during summer (>40psu) but it does not affect significantly the wells around it. The lagoon is well oxygenated, while the wells have lower D.O. values. Ammonia and nitrates are the main inorganic Nitrogen forms, in the lagoon and the wells, respectively. Phosphorus is the limiting factor for phytoplankton growth. Human activities affect the area that is in need of an environmental management plan in order to prevent ecological degradation.

In the current paper are presented the results of a multidisciplinary study (stratigraphical, sedimentological, geophysical and geochemical) combined with modern techniques (G.I.S. and remote sensing). This study aims at integrating the natural and anthropogenic factors affecting the Korissia lagoon. It is a shallow coastal lagoon, communicating with the sea via an artificial channel. The area around the lagoon consists of alluvial sediments hosting, in places, newly formed and/or “old” (pre – Holocene) sand-dunes. The broader area constitutes a postalpine sedimentary basin characterised by smooth morphological relief. The lower stratigraphic unit of the post-alpine sequence is a Pleistocene marly formation, which was detected as the basement (5-15 Οhm.m) by the geophysical survey. The resistivity-based basement map implies the existence of a “palaeo-gulf” trending EW. These marls constitute the impermeable basement of a shallow aquifer hosted in the area. The salinity of the lagoon is very high during summer (>40psu) but it does not affect significantly the wells around it. The lagoon is well oxygenated, while the wells have lower D.O. values. Ammonia and nitrates are the main inorganic Nitrogen forms, in the lagoon and the wells, respectively. Phosphorus is the limiting factor for phytoplankton growth. Human activities affect the area that is in need of an environmental management plan in order to prevent ecological degradation.

We examine the intersubband transition dynamics of a single semiconductor quantum well when the ground and the first excited subbands are coupled by strong electromagnetic fields, with emphasis given to controlled intersubband population inversion. The system dynamics is described by the nonlinear density matrix equations that include the effects of electron‐electron interactions. We present analytical results for the electromagnetic field that can lead to high‐efficiency population inversion in the system. The validity of the analytical results is tested with numerical solutions of the density matrix equations for various values of the electron sheet density for a realistic GaAs/AlGaAs quantum well.

The Author list was incomplete in ATel#1152. On 2007 July 21.46 UT a spectrum of the nova candidate M31N 2007-07c (see ATel#1146, ATel#1149) was obtained with Double-Beam Spectrograph on the Palomar Hale-5m telescope. The 400/6000 grism (3.5 angstrom FWHM) and 158/7500 grating (8.6 angstrom FWHM) were used with 1200s exposure, each. The H-alpha line displays a P-Cygni profile. The measured expansion velocity is -1630+/-20 km/ sec (blue shifted), based on measurements of the Ca H+K lines, the G Band, H-beta, Mg lines and the near-infrared Ca-triplet.

Objective: To evaluate the cytokine concentration patterns during the first 5 days of life by measuring serum concentrations of type-1 cytokines, like interleukin-2 (IL-2) and interferon-γ (IFN-γ) and type-2 cytokines, like IL-4, as well as the receptors of IL-2 (sIL-2R) and IL-4 (sIL-4R) during the early neonatal period. Subjects and methods: Forty-two healthy term neonates were included in the study. Cytokine concentrations were measured in umbilical cord, in the 1st and 5th day after birth and compared with those in serum of 30 healthy adults. Results: IL-2 concentrations presented a decrease trend from umbilical cord to 5th day, while sIL-2R showed a significant elevation from umbilical cord to 5th day after birth. IL-4 concentrations did not differ significantly among umbilical cord, the 1st and the 5th day, while the sIL-4R showed the highest values in the 1st day after birth. Both IL-4 and sIL-4R concentrations in neonatal samples were elevated compared to adults. IFN-γ concentrations increased significantly from umbilical cord to 5th day of life. Conclusion: Our findings indicate a dysregulation among IL-2, IL-4 and IFN-γ concentrations during the 1st day after birth, favoring a more precocious expression of IL-2 and IL-4 against IFN-γ that seems to be ameliorated in the end of the 1st week of life. © 2006 Elsevier Ireland Ltd. All rights reserved.

As evidenced by the development of tools that enable proper analysis of river systems, floodplain modeling is more important than ever before. Current legislative and socioeconomic aspects of integrated water resource management often require a hydraulic analysis prior to development or construction in a floodplain. To aid in accurate floodplain modeling, scientists use computer models in planning and analyzing floodplain hydraulic situations while having difficult modeling problems depending on data needs and data availability. On the one hand, floodplain models are successful in dealing with time variation, and models with hundreds or even thousands of time steps are common. On the other hand, spatial disaggregating of the study area has been relatively simple, assuming, in many cases, uniform spatial properties or allow for small numbers of spatial subunits within which properties are uniform. Geographical Information Systems (GIS) offer the potential to increase the degree of definition of spatial subunits, in number and in descriptive detail. This paper focuses in integrating GIS and floodplain modeling in order to produce fast, accurate and easy to understand, through thematic and animated maps, results, through the development of an integrated Decision Support System (DSS). The system was applied in Prasianos watershed, Rethimnon, Crete isl., to enable prediction of spatial runoff distribution, calculate flood hydrographs and simulate the flooding following an earthen dam breach.

The Karlovassi Basin is an area that has suffered many catastrophic events such as fires or floods within the last 10 years. These intense phenomena, that take place mostly at its northern part, along with the human activities, have significantly accelerated the evolution rate of the local landforms. The result is the noticeable alteration of the geomorphological landscape within these last ten years.When dealing with landscape evolution, the time is a basic factor since it determines the intensity of the morphologic development. For this paper we used an algorithm for the temporal analysis of the changes in the landscape, because of the erosional processes. The software that has been developed to apply the algorithm is GIS based and uses the concept of the cellular automata for the geospatial calculations. For each grid cell it calculates the altitude and soil thickness of the area, based on the continuity equation, which involves parameters of different natural processes such as the weathering of rocks, the river and slope sediment yield, etc. Since time is an important factor in this equation, each parameter is characterized as timeconstant or time dependent. The temporal variation of the physical process parameters is expressed by simple mathematical expressions, which may represent time constant values, as well as abrupt, smooth or periodical variations with time.This algorithm may support the local authorities in decision making issues, since it may identify the areas that require protection against the intense physical phenomena of the last years. Moreover, it may be useful in geomorphological and environmental research, concerning the way that some landforms evolve.

The purpose of the present study was to describe the development and validation of the Self-Talk Questionnaire (S-TQ), designed to measure two functions of self-talk strategies, namely the motivational function and the cognitive function, used by athletes to enhance their sport performances. The study was conducted in three phases. The first phase targeted item selection and content relevance. The second phase set out to test the factor structure of the instrument. The aim of the third phase was focused on further examination of the psychometric properties of the instrument. The results of an exploratory factor analysis provided adequate support for the instrument. The S-TQ consists of 11 items, representing two factors (motivational and cognitive). A confirmatory factor analysis showed an acceptable fit to the data. The factors were internally consistent, the correlations with external criteria were significant, and test-retest reliability values were very good. Examining the relationships between the S-TQ and similar constructs supported convergent validity. Discriminant validity was supported by correlations between the S-TQ and a different construct. The S-TQ appears to be a promising psychometric instrument that can be used in research and psychological intervention programs.

In the present paper we develop a software in order to describe, in quantitative terms, the time variation of the shape and dimensions of a landform. The software is based on an iterative cellular automata algorithm. In each step, the algorithm calculates the altitude and soil thickness of each cell, which represents a piece of land. The calculations are based on the continuity equation. Parameters which express the intensity of weathering of rock masses, soil transport along slopes and fluvial transport of sediments by rivers (physical processes parameters), are incorporated in the continuity equation, using empirical relations. These parameters may be time constant or time dependent. The physical meaning of a time dependent parameter is that the rate of a geomorphological process may change with time, as a result of human activities or changes in the climate. The temporal variation of the physical processes parameters are expressed by simple mathematical expressions, which may represent smooth, rapid or periodical changes.This software may be useful in geomorphological and environmental research, inorder to estimate the future development of a landform, as a result of physicalprocesses and human activities.

This paper is based on the research on the possible structure of an information system for the purposes of occupational health and safety management. We initiated a questionnaire in order to find the possible interest on the part of potential users in the subject of occupational health and safety. The depiction of the potential interest is vital both for the software analysis cycle and development according to previous models. The evaluation of the results tends to create pilot applications among different enterprises. Documentation and process improvements ascertained quality of services, operational support, occupational health and safety advice are the basics of the above applications. Communication and codified information among intersted parts is the other target of the survey regarding health issues. Computer networks can offer such services. The network will consist of certain nodes responsible to inform executives on Occupational Health and Safety. A web database has been installed for inserting and searching documents. The submission of files to a server and the answers to questionnaires through the web help the experts to perform their activities. Based on the requirements of enterprises we have constructed a web file server. We submit files so that users can retrieve the files which they need. The access is limited to authorized users. Digital watermarks authenticate and protect digital objects.

Alzheimer's disease (AD) is increasing in prevalence. There are no known preventive or curative measures. There is evidence that oxidative stress, homo-cysteine-related vitamins, fats, and alcohol have a role in the pathogenesis of AD. Some epidemiologic studies suggest that higher dietary intake of antioxidants, vitamins B(6), B(12), and folate, unsaturated fatty acids, and fish are related to a lower risk of AD, but reports are inconsistent. Modest to moderate alcohol intake, particularly wine, may be related to a lower risk of AD. The Mediterranean diet may also be related to lower AD risk. However, randomized clinical trials of supplements of vitamins E, B(12), B(6), and folate have shown no cognitive benefit, and randomized trials for other nutrients or diets in AD are not available. The existing evidence does not support the recommendation of specific supplements, foods, or diets for the prevention of AD.

The aim of the present study was to investigate whether replacement of broad-spectrum cephalosporins (CEPs) by piperacillin/tazobactam (TZP) as first-line empirical therapy may have an effect on beta-lactam resistance among Klebsiella pneumoniae and Escherichia coli in a tertiary care hospital. Data regarding CEP and TZP consumption and resistance were collected on a bimonthly basis during an open-label 2-year (1 year observational and 1 year interventional) study. Consumption of ceftazidime was reduced by 64.5%. In contrast, consumption of the other third-generation CEPs (cefotaxime and ceftriaxone) remained almost stable, whereas an increase in consumption of TZP by 2.8-fold was observed. A significant decrease in resistance to third-generation cephalosporins among K. pneumoniae isolates was observed, and the incidence of extended-spectrum beta-lactamase-producing isolates was notably reduced. These findings were less evident among E. coli isolates. Despite the significant increase in TZP consumption, the respective resistance rates of both bacterial species examined have remained almost unchanged.

The evolution of imipenem disk-diffusion susceptibility results of 2652 strains of Klebsiella pneumoniae and 7596 Escherichia coli isolated during the period 2000-2005 were analysed. Screening for production of metallo-beta-lactamases was performed using the EDTA-synergy method. The percentage rate of K. pneumoniae isolates having a zone diameter < or =25 mm increased from 20% in 2000 to 41% in 2005, whereas the respective rate of isolates having a zone diameter > or =30 mm decreased from 48 to 23%. These changes were more evident during 2000-2002, followed in 2003 by the isolation of the first imipenem-resistant strains. Regarding E. coli, a similar decrease was observed (the rates of isolates having a zone diameter < or =25 mm and > or =30 mm changed from 7% and 68% in 2000, to 32% and 36% in 2005, respectively) following the respective changes of K. pneumoniae. A total of 20 K. pneumoniae strains, but no E. coli, were confirmed as metallo-beta-lactamase producers. In conclusion, a decrease of the imipenem susceptibility prior to the isolation of the first resistant strains in a tertiary care hospital was detected, as well as differences in this decrease between the two species. These findings indicate that monitoring of the evolution of imipenem susceptibility in real-time may help in unveiling forthcoming resistance and in implementing the appropriate diagnostic techniques.

Temperature sensitivity of digestive processes has important ramifications for digestive performance in ectothermic vertebrates. We conducted a comparative analysis of temperature effects on digestive processes [gut passage times (GPTs) and apparent digestive efficiencies (ADEs)] in five lacertid lizards occurring in insular ( Podarcis erhardii, P. gaigeae ), and mainland ( P. muralis, P. peloponnesiaca, Lacerta graeca ) Mediterranean environments. GPTs were negatively correlated to temperature with mainland taxa having 10–20% longer GPTs than island taxa. In contrast to previous studies that estimate ADEs using bomb calorimetry, we compare ADEs by analyzing discrete efficiencies for lipids, sugars and proteins at three temperature regimes (20, 25, and 30°C); each of these categories produces different results. ADEs for lipids and sugars showed a monotonic increase with temperature whereas ADEs for proteins decreased with temperature. Island taxa had consistently higher ADEs than their mainland counterparts for lipids and for proteins but not for sugars. They are characterized by superior energy acquisition abilities despite significantly shorter GPTs. Their increased digestive performance relative to the mainland species appears to allow them to maximize energy acquisition in unproductive island environments where food availability is spatially and seasonally clustered.

A 44-year old male patient with a past medical history of a complete surgical excision of pelvic hydatid cyst two years previously presented with constant pelvic floor pain and plasma IgG anti-echinococcal antibody titres of 14.27 U/mL. Based on that and the imaging findings of abdominal ultrasound (US), Computed Tomography (CT) and Magnetic Resonance (MR) the diagnosis of a recurrent retrorectal pelvic hydatid cyst was made. Three courses of oral albendazole treatment were administered and sixteen weeks later, the patient was admitted for a planned elective operation. At that time, a new CT scan revealed disappearance of the cyst, while the serological tests showed a decrease in the IgG anti-echinococcal antibody titres to 0. 71 U/mL. Four different species of the Echinococcus tapeworm can produce infection in humans. E granulosus and E multilocularis are the most common, causing cystic and alveolar echinococcosis respectively, while E vogeli and E oligarthrus, have only rarely been associated with human infection. Although surgical resection remains the treatment of choice for hydatid disease, the present case could suggest that especially in cases of recurrent intraabdominal extrahepatic hydatid cyst, treatment with albendazole may lead to disappearance of the recurrent cyst therefore, should constitute a first line therapeutic option prior to any planned reoperation.

1. Καμπερίδου, Ειρήνη (2007). Απόψεις Ξένων Περιηγητριών για την Περίοδο της Τουρκοκρατίας: «Δυστυχώς οι πόλεις είναι γεμάτες Έλληνες (1853). ΦΙΛΟΣΟΦΙΑ & ΠΑΙΔΕΙΑ, Περιοδική Επιστημονική Έκδοση της Ένωσης Καθηγητών για την Προαγωγή της Φιλοσοφίας στην Εκπαίδευση (ΕΚΔΕΦ), ‘Έτος 13ο , Τεύχος 41 (Ιανουάριος-Απρίλιος 2007): 34-37.    J.5 in APELLA

• [Kamberidou, I. (2007). Discourse/Observations on the Hellenes (Greeks) by 19th century western women travellers: "Unfortunately the cities are full of Greeks- 1853". Philosophy & Education (EKDEF), issue 41, Jan.-April 2007, 34-37. J.5 in APELLA

BACKGROUND: Disruptive behavior is common in Alzheimer disease (AD). There are conflicting reports regarding its ability to predict cognitive decline, functional decline, institutionalization, and mortality. OBJECTIVE: To examine whether the presence of disruptive behavior has predictive value for important outcomes in AD. DESIGN: Using the Columbia University Scale for Psychopathology in Alzheimer Disease (administered every 6 months, for a total of 3438 visit-assessments and an average of 6.9 per patient), the presence of disruptive behavior (wandering, verbal outbursts, physical threats/violence, agitation/restlessness, and sundowning) was extracted and examined as a time-dependent predictor in Cox models. The models controlled for the recruitment cohort, recruitment center, informant status, sex, age, education, a comorbidity index, baseline cognitive and functional performance, and neuroleptic use. SETTING: Five university-based AD centers in the United States and Europe (Predictors Study). PARTICIPANTS: Four hundred ninety-seven patients with early-stage AD (mean Folstein Mini-Mental State Examination score, 20 of 30 at entry) who were recruited and who underwent semiannual follow-up for as long as 14 (mean, 4.4) years. MAIN OUTCOME MEASURES: Cognitive (Columbia Mini-Mental State Examination score, < or = 20 of 57 [approximate Folstein Mini-Mental State Examination score, < or = 10 of 30]) and functional (Blessed Dementia Rating Scale score, parts I and II, > or = 10) ratings, institutionalization equivalent index, and death. RESULTS: At least 1 disruptive behavioral symptom was noted in 48% of patients at baseline and in 83% at any evaluation. Their presence was associated with increased risks of cognitive decline (hazard ratio 1.45 [95% confidence interval (CI), 1.03-2.03]), functional decline (1.66 [95% CI, 1.17-2.36]), and institutionalization (1.47 [95% CI, 1.10-1.97]). Sundowning was associated with faster cognitive decline, wandering with faster functional decline and institutionalization, and agitation/restlessness with faster cognitive and functional decline. There was no association between disruptive behavior and mortality (hazard ratio, 0.94 [95% CI, 0.71-1.25]). CONCLUSION: Disruptive behavior is very common in AD and predicts cognitive decline, functional decline, and institutionalization but not mortality.

c-Jun is a transcription factor activated by phosphorylation by the stress-activated protein kinase/c-Jun N-terminal kinase pathway in response to extracellular signals and cytokines. We show that adenovirus-mediated gene transfer of the dominant negative form of c-Jun (dn-c-Jun) in C57BL/6 mice increased greatly apoE hepatic mRNA and plasma levels, increased plasma cholesterol, triglyceride, and very low density lipoprotein levels, and resulted in the accumulation of discoidal high density lipoprotein particles. A similar but more severe phenotype was generated by overexpression of the mouse apoE in C57BL/6 mice, suggesting that dyslipidemia induced by dn-c-Jun was the result of apoE overexpression. Unexpectedly, infection of apoE(-/-) mice with adenovirus expressing dn-c-Jun reduced plasma cholesterol by 70%, suggesting that dn-c-Jun affected other genes that control plasma cholesterol levels. To identify these genes, we performed whole genome expression analysis (34,000 genes) of isolated livers from two groups of five apoE(-/-) mice, infected with adenoviruses expressing either the dn-c-Jun or the green fluorescence protein. Bioinformatic analysis and Northern blotting validation revealed that dn-c-Jun increased 40-fold the apoE mRNA and reduced by 70% the Scd-1 (stearoyl-CoA-desaturase 1) mRNA. The involvement of Scd-1 in lowering plasma cholesterol was confirmed by restoration of high cholesterol levels of apoE(-/-) mice following coinfection with adenoviruses expressing dn-c-Jun and Scd-1. In conclusion, dn-c-Jun appears to trigger two opposing events in mice that affect plasma cholesterol and triglyceride levels as follows: one results in apoE overexpression and triggers dyslipidemia and the other results in inhibition of Scd-1 and offsets dyslipidemia.

In this study, an attempt is made to investigate possible teleconnection patterns of atmospheric circulation, centered over eastern Mediterranean (EM) with the aid of gridded NCEP/NCAR daily values of geopotential heights for the period 1958-2003. For this purpose, two approaches have been used: correlation analysis and rotated principal component analysis (PCA) on a seasonal and monthly basis. A teleconnection pattern between the EM and northeastern Atlantic was identified at 500 and 300 hPa in winter, which will be referred to as the Eastern Mediterranean Pattern (EMP), appearing as an independent mode of the upper circulation. The pattern also exists in autumn but is substantially weakened with its dipole centers being shifted eastwards. Significant monthly variations were found in the location, strength and structure of the pattern. The employment of a standardized index demonstrated that the negative phase of the EMP prevails throughout the year with the maximum frequency at wintertime. Copyright © 2006 Royal Meteorological Society.

OBJECTIVES: To report on recent efforts in the field of consumer health informatics (CHI) and education. METHODS: A review of the literature we selected on using search engines and Medline with terms from consumer health informatics and education. Twenty two articles match these criteria. RESULTS: A great diversity of work spans the field of CHI. This relatively new field now faces challenges due to rapidly advancing technologies and the increasing empowerment of citizens connected over the worldwide web. CONCLUSION: The benefits of enhancing CIH components within existing medical curricula are already being noted. Additionally, updated recommendations on health and medical informatics should incorporate CHI.

The rationale of this magnetoencephalographic (MEG) study was the quest for temporal aspects of the fMRI-characterized hemispheric asymmetries of auditory cortex functions during the processing of simple linearly frequency-modulated (FM) tones. We searched for parameters which distinguish a stimulus-related task condition—the categorical discrimination of direction (upward versus downward) of frequency modulation—from mere exposure to the same FM tones. We found that the M100-peak latency after FM tones was significantly shorter in the task condition than in the exposure condition, in the left but not in the right hemisphere.

OBJECTIVES: Aim of this study is the evaluation of the impact of a multimedia CD (MCD) on preoperative anxiety and postoperative recovery of patients undergoing elective laparoscopic cholecystectomy (LC). METHODS: Sixty consecutive candidates for elective LC were randomly assigned to four groups. Group A included 15 patients preoperatively informed regarding LC through the MCD presented by Registered Nurse (RN). Patients in group B (n = 15) were informed through a leaflet. Patients in group C (n = 15) were informed verbally from a RN. Finally, the control Group D included 15 patients informed conventionally by the attending surgeon and anesthesiologist, as every other patient included in groups A, B, and C. Preoperative assessment of knowledge about LC was performed after each informative session through a questionnaire. Evaluation of preoperative anxiety was conducted using APAIS scale. Postoperative pain and nausea scores were measured using an NRS scale, 16 hours after the patient had returned to the ward. RESULTS: Statistical processing of the results (single linear regression) showed that patients in groups A, B, and C achieved a higher knowledge score, less preoperative anxiety score and less postoperative pain and nausea, compared to Group D. In multiple regression analysis, group A had a higher knowledge score compared to the four groups (p < 0.001 r(2) = 0.41). CONCLUSION: Informative sessions using MCD is an effective means of improving patient's preoperative knowledge, especially in day-surgery cases, like LC.

Immunomodulatory drugs (IMiDs) and bortezomib have been recently used in the management of patients with both newly diagnosed and relapsed/ refractory multiple myeloma. Except of their direct anti-myeloma effect, these agents also alter the interactions between myeloma cells and marrow microenvironment. Several recent studies have investigated their potential effect on myeloma bone disease. Preclinical studies have demonstrated that IMiDs reduce osteoclast formation and function in vitro. Clinical studies have confirmed that thalidomide reduces markers of bone resorption, while lenalidomide induces osteoclast arrest in myeloma patients. However, IMiDs seem to have no effect on osteoblast exhaustion present in myeloma. The proteasome inhibitor bortezomib restores abnormal bone remodeling through the inhibition of osteoclast function and the increase in osteoblast differentiation and activity in vitro. In myeloma patients, bortezomib reduces biochemical markers of bone resorption and normalizes the RANKL/osteoprotegerin ratio, while at the same time increases bone formation markers reducing levels of dickkopf-1 protein. Whether these effects are direct and not only a consequence of the agents' antimyeloma activity is not totally clear. This review summarizes all available data for these attractive agents that combine potent anti-myeloma activity with beneficial effects on bone and may alter the way of management of myeloma-related bone disease.

BACKGROUND: A 9-month course of isoniazid monotherapy is currently recommended for the treatment of latent tuberculosis infection (LTBI) and has been shown to be effective in both children and adults. Reduced compliance with this regimen has forced physicians to explore shorter regimens. The aim of this study was to compare 3- and 4-month combination regimens of isoniazid plus rifampin with a 9-month regimen of isoniazid monotherapy for the treatment of LTBI in children. METHODS: This prospective, randomized, controlled study was conducted over an 11-year period (1995-2005). In period 1 (1995-1998), 232 patients received isoniazid therapy for 9 months (group A), and 238 patients received isoniazid and rifampin for 4 months (group B). In period 2 (1999-2002), 236 patients were treated with isoniazid and rifampin for 4 months (group C), and 220 patients received the same regimen for 3 months (group D). All patients were observed for > or = 3 years. RESULTS: Overall compliance with treatment was good, but patients who received isoniazid monotherapy were less compliant than were those who received short-course combination therapy (P=.011, for group A vs. group B; P=.510, for group C vs. group D). No patient in any group developed clinical disease during the follow-up period. New radiographic findings suggestive of possible active disease were more common in patients who received isoniazid monotherapy (24%) than in those treated with shorter regimens (11.8%, 13.6%, and 11% for groups B, C, and D, respectively; P=.001 for group A vs. group B; P=.418 for group C vs. group D). Serious drug-related adverse effects were not detected. CONCLUSIONS: Short-course treatment with isoniazid and rifampin for 3-4 months is safe and seems to be superior to a 9-month course of isoniazid monotherapy.

BACKGROUND: Skeletal muscle wasting commonly occurs in patients with chronic obstructive pulmonary disease (COPD) and has been associated with the presence of systemic inflammation. This study investigated whether rehabilitative exercise training decreases the levels of systemic or local muscle inflammation or reverses the abnormalities associated with muscle deconditioning. METHODS: Fifteen patients with COPD (mean (SE) forced expiratory volume in 1 s 36 (4)% predicted) undertook high-intensity exercise training 3 days/week for 10 weeks. Before and after the training programme the concentration of tumour necrosis factor alpha (TNFalpha), interleukin-6 (IL-6) and C-reactive protein (CRP) in plasma was determined by ELISA, and vastus lateralis mRNA expression of TNFalpha, IL-6, total insulin-like growth factor-I (IGF-I) and its isoform mechanogrowth factor (MGF) and myogenic differentiation factor D (MyoD) were assessed by real-time PCR. Protein levels of TNFalpha, IGF-I and MyoD were measured by Western blotting. RESULTS: Rehabilitation improved peak exercise work rate by 10 (2%) (p = 0.004) and mean fibre cross-sectional area from 4061 (254) microm(2) to 4581 (241) microm(2) (p = 0.001). Plasma inflammatory mediators and vastus lateralis expression of TNFalpha and IL-6 were not significantly modified by training. In contrast, there was a significant increase in mRNA expression of IGF-I (by 67 (22)%; p = 0.044), MGF (by 67 (15)%; p = 0.002) and MyoD (by 116 (30)%; p = 0.001). The increase observed at the mRNA level was also seen at the protein level for IGF-I (by 72 (36)%; p = 0.046) and MyoD (by 67 (21)%; p = 0.012). CONCLUSIONS: Pulmonary rehabilitation can induce peripheral muscle adaptations and modifications in factors regulating skeletal muscle hypertrophy and regeneration without decreasing the levels of systemic or local muscle inflammation.

{This study evaluated and compared the effectiveness of two different off-season, short-term basketball training programs on physical and technical abilities of young basketball players. Twenty-seven adolescent basketball players (14.7 ± 0.5 years; Tanner stage: 3.5 ± 0.5) were randomly divided into a specialized basketball training group (SP

{This study evaluated and compared the effectiveness of two different off-season, short-term basketball training programs on physical and technical abilities of young basketball players. Twenty-seven adolescent basketball players (14.7 ± 0.5 years; Tanner stage: 3.5 ± 0.5) were randomly divided into a specialized basketball training group (SP

This study evaluated and compared the effectiveness of two different off-season, short-term basketball training programs on physical and technical abilities of young basketball players. Twenty-seven adolescent basketball players (14.7 ± 0.5 years; Tanner stage: 3.5 ± 0.5) were randomly divided into a specialized basketball training group (SP, n = 10), a mixed basketball plus conditioning training group (MX, n = 10) and a control group (n = 7). Training included five sessions per week (100-120 min each) and was performed for 4 weeks. Maximal oxygen uptake was similarly improved after SP (4.9 ± 1.8%) and MX (4.9 ± 1.4%), but there was no effect on ventilatory threshold. Peak and mean power output measured during the Wingate test were also improved by a similar magnitude after SP (21 ± 5%) and MX (15 ± 6%). Trunk muscle endurance was equally increased (SP: 23 ± 4%, MX: 25 ± 5%), but arms endurance was improved significantly more after MX (50 ± 11%) compared to SP (11 ± 14%, p < 0.05). Performance in four basketball technical skills was similarly increased (by 17-27%) in both groups, with a tendency for greater improvement of the SP groups in the technical skills of shooting and passing. These results indicate that a SP basketball training program, performed exclusively on-court was as effective as a MX training program in terms of aerobic and anaerobic fitness improvement. Furthermore, the decrease of the total on-court training time in the MX group resulted in a tendency for a smaller improvement of basketball technical skills. In conclusion, both SP and MX training are equally effective in order to limit and/or reverse the detraining effects that occur during the off-season in basketball. © 2006 Sports Medicine Australia.

The Leonardo project under the name European Interprofessional Education Network (EIPEN) in health and social care, has been dealing with the challenges of Interprofessional Education (IPE). The EIPEN project tries to develop a transnational network of universities and employers in the six participating countries and at the same time to promote good practices in Interprofessional LearningTeaching in healthsocial care. IPE provides opportunities for students and practitioners to learn with, from and about each other during qualifying and post-qualifying training and in their practice. IPE in health and social care includes the education and training of practitioners in human and animal medicine, dentistry, nursing, physiotherapy, occupational therapy, pharmacy and all other health professions including public and environmental health and health promotion, and social work. The outcomes of the EIPEN Project will provide means, material and guidelines for the enhancement of professional education in the multidisciplinary field of Health Informatics.

The present work demonstrates the first application of Brillouin light scattering (BLS) to probe film-guided elastic waves in transparent-substrate supported polymer thin films. In comparison with earlier BLS studies that were restricted to films either free-standing or supported on opaque substrates, the progress made in this work substantially extends the applicability of BLS and permits direct access to the elastic properties of thin films lying on transparent substrates, which is of important practical relevance. A series of thin supported polystyrene and poly(methyl methacrylate) films with thickness in the range of 40−500 nm were explored, and no noticeable trend in elastic properties with thickness has been found, in conformity with earlier BLS results. The first measurement of glass transition temperature, Tg, of supported polymer thin films by BLS is also reported. We observed that the ultrathin (40 nm) films for both polymers exhibit a clear reduction in Tg.

The book is a detailed study on the structure and the topics of Ovid’s compedium of the Trojan Saga in Metamorphoses 12.1-13.622, the section also referred to as the “Little Iliad”. It explores the motives and the objectives behind the selected narrative moments from the Epic Cycle that found their way into the Ovidian version of the Trojan War. By thoroughly mastering and inspiringly refashioning a vast amount of literary material, Ovid generates a systematic reconstruction of the archetypal hero, Achilles. Thus, he projects himself as a worthy successor of Homer in the epic tradition, a master epicist, and a par to his great Latin predecessor, Vergil.

Hydatid disease, although endemic mostly in sheep-farming countries, remains a public health issue worldwide, involving mainly the liver. Intrabiliary rupture is the most frequent complication of the hepatic hydatid cyst. Endoscopy is advocated, preoperatively, to alleviate obstructive jaundice caused by intracystic materials after a frank rupture and is also a useful and well-established adjunct in locating postoperative biliary fistulas. Endoscopic retrograde cholangiography with sphincterotomy has been successful as the sole and definitive means of treatment of intrabiliary ruptured hydatid cysts. A case of an elderly woman with frank rupture is presented, where the rupture was definitively managed endoscopically in conjunction with sphincterotomy to remove the intrabiliary obstructive daughter cysts and to achieve decontamination of the biliary tree. Endoscopic retrograde cholangiography provided an excellent diagnostic and therapeutic modality in the present case and, thus, it should be considered as definitive treatment in similar cases especially if surgical risk is anticipated to be high.

In this work we study the transport properties of hybrids that consist of exchange biased ferromagnets (FMs) combined with a low-T-c superconductor (SC). Not only different FMs but also various structural topologies have been investigated: results for multilayers of La1-xCaxMnO3 combined with Nb in the form of [La0.33Ca0.67MnO3/La0.60Ca0.40MnO3](15)/Nb, and for more simple Ni80Fe20/Nb/Ni80Fe20 trilayers and Ni80Fe20/Nb bilayers are presented. The results obtained in all hybrid structures studied in this work clearly uncover that the exchange bias mechanism promotes superconductivity. Our findings assist the understanding of the contradictory results that have been reported in the recent literature regarding the transport properties of relative FM/SC/FM spin valves.

We have studied the spatial and temporal variation of the surface longwave radiation (downwelling and net) over a 21-year period in the tropical and subtropical Pacific Ocean (40 S-40 N, 90 E-75 W). The fluxes were computed using a deterministic model for atmospheric radiation transfer, along with satellite data from the ISCCP-D2 database and reanalysis data from NCEP/NCAR (acronyms explained in main text), for the key atmospheric and surface input parameters. An excellent correlation was found between the downwelling longwave radiation (DLR) anomaly and the Ni&ntilde;o-3.4 index time-series, over the Ni&ntilde;o-3.4 region located in the central Pacific. A high anti-correlation was also found over the western Pacific (15-0 S, 105-130 E). There is convincing evidence that the time series of the mean downwelling longwave radiation anomaly in the western Pacific precedes that in the Ni&ntilde;o-3.4 region by 3-4 months. Thus, the downwelling longwave radiation anomaly is a complementary index to the SST anomaly for the study of ENSO events and can be used to asses whether or not El Ni&ntilde;o or La Ni&ntilde;a conditions prevail. Over the Ni&ntilde;o-3.4 region, the mean DLR anomaly values range from +20 Wm-2 during El Ni&ntilde;o episodes to -20 Wm-2 during La Ni&ntilde;a events, while over the western Pacific (15-0 S, 105-130 E) these values range from -15 Wm-2 to +10 Wm-2, respectively. The long- term average (1984-2004) distribution of the net downwelling longwave radiation at the surface over the tropical and subtropical Pacific for the three month period November-December-January shows a net thermal cooling of the ocean surface. When El Ni&ntilde;o conditions prevail, the thermal radiative cooling in the central and south-eastern tropical Pacific becomes weaker by 10 Wm-2 south of the equator in the central Pacific (7-0 S, 160-120 W) for the three-month period of NDJ, because the DLR increase is larger than the increase in surface thermal emission. In contrast, the thermal radiative cooling over Indonesia is enhanced by 10 Wm-2 during the early (August-September-October) El Ni&ntilde;o phase.

INTRODUCTION: Taking into consideration the need for an updated survey on acute myocardial infarction (AMI) in Greece, we conducted the HELIOS study (HELlenic Infarction Observation Study), aiming to recruit a cohort of AMI patients that would be representative of the total AMI population. METHODS: The HELIOS study is a countrywide registry of AMI, conducted during 2005-2006 by the Prevention Working Group of the Hellenic Cardiological Society. We enrolled 1840 AMI pts from 31 hospitals (mean age 68 +/- 13 years, 75% men, 1096 ST-elevation myocardial infarction [STEMI] patients), with a proportional representation of all types of hospitals and of all geographical areas. The study recruited 10% of the total number of AMI cases that occur per year on a countrywide basis, taking into consideration the seasonal variations of the population in each geographical area. RESULTS: Despite demographic changes, there is still a male predominance among AMI patients and an increasing prevalence of cardiometabolic risk factors, (obesity, diabetes, hypertension) compared to previous AMI studies in the Greek population. Almost 60% of STEMI patients received reperfusion therapy, but the median value of the pain-to-door time was 180 minutes. The rates of administration of evidence-based medications during hospitalisation or upon discharge and the short-term mortality rates were in accordance with those observed in other international AMI registries. CONCLUSIONS: The HELIOS study provided valuable insights into the epidemiology, clinical characteristics, management and outcome of patients with AMI in the Greek population. Although there are notable advances compared to previous reports, there is still considerable room for improvement and we should particularly focus on minimising the time delay between arrival at the emergency department and performance of reperfusion, by either pharmacological or catheter-based approaches.

We retrospectively investigated the outcome of epithelial ovarian cancer (EOC) in women less than 45 years and over 70 years treated with cisplatin-based chemotherapy. We also investigated the impact of various factors on patients' survival. The tumor registry of the Hellenic Cooperative Oncology Group was used to identify women less than 45 years and over 70 years with EOC diagnosed between 1979 and 2004. Survival was calculated by the Kaplan-Meier method, and Cox proportional hazard models were used to determine the independent effect of each variable on survival. Of 1748 EOC patients, 200 were 45 or younger and 282 were over 70 years old. In the univariate analysis, younger age (P < 0.001), better performance status (PS) (P < 0.001), early stage (P < 0.001), 0-2 cm residual disease (P < 0.001), and well or moderate differentiation grade (P = 0.004) were significant prognostic factors for improved survival. In the multivariate analysis, older age (hazard ratio [HR]: 1.88, 95% CI: 1.27-2.77, P = 0.002), advanced stage (HR: 2.87, 95% CI: 1.49-5.52, P = 0.002), PS >1 (HR: 1.91, 95% CI: 1.18-3.08, P = 0.008), and residual disease (HR: 1.46, 95% CI: 1.01-2.13, P = 0.046) were independently associated with inferior survival. With a median follow-up of 45 months (range 0.1-197 months), median survival (118.5 months) of younger patients differed significantly compared to that of older patients (33 months) (P < 0.001). In conclusion, younger women with EOC have significantly improved survival compared to older patients. Age, PS, stage of the disease at diagnosis, and residual disease are important independent predictors for survival. © 2007, IGCS and ESGO.

We consider a single server Markovian queue with setup times. Whenever this system becomes empty, the server is turned off. Whenever a customer arrives to an empty system, the server begins an exponential setup time to start service again. We assume that arriving customers decide whether to enter the system or balk based on a natural reward-cost structure, which incorporates their desire for service as well as their unwillingness to wait. We examine customer behavior under various levels of information regarding the system state. Specifically, before making the decision, a customer may or may not know the state of the server and/or the number of present customers. We derive equilibrium strategies for the customers under the various levels of information and analyze the stationary behavior of the system under these strategies. We also illustrate further effects of the information level on the equilibrium behavior via numerical experiments. © 2007 Springer Science+Business Media, LLC.

BACKGROUND: Inhibition of lung cell apoptosis in the bronchoalveolar lavage (BAL) of septic patients may have a prognostic value for the severity of sepsis. The present study evaluated apoptosis in the nasal and buccal mucosa of septic patients as an alternative and less invasive approach for studying the cells involved in bronchial inflammation. PATIENTS AND METHODS: A prospective study was designed. Nasal and buccal mucosa brushings were obtained from 20 consecutive septic patients who were admitted to two intensive care units. Twenty-four patients scheduled to undergo surgery for colorectal cancer or laparascopic cholocystectomy were the control group. Apoptosis was evaluated using a TUNEL assay, while BCL-2 and BAX expression were evaluated by immunohistochemistry. RESULTS: Significantly reduced apoptosis in the nasal mucosa of septic patients compared to the control group (p=0.043) was detected only by the TUNEL assay. CONCLUSION: Reduced apoptosis was found during sepsis in the nasal mucosa in accordance with the reduced apoptosis in the lungs of septic patients. In contrast to septic lungs the underlying mechanism leading to apoptosis in the nasal mucosa was unrelated to the expression of two apoptosis-related genes BCL-2 and BAX.

Lenalidomide is an immunomodulatory drug, structurally related to thalidomide, which has pleotropic activity, including antiangiogenic and antineoplastic properties. This agent is the product of advances in the understanding of the biology of neoplastic cells, their interaction with the microenvironment and of the underlying molecular pathways. Lenalidomide has shown significant activity in refractory/resistant multiple myeloma, and further studies have shown its activity in other hematologic malignancies with some very encouraging results, especially in subsets of patients with myelodysplastic syndromes. This article reviews the data on lenalidomide use in patients with multiple myeloma, as well as in myelodysplastic syndromes, chronic lymphocytic leukemia and myelofibrosis with myeloid metaplasia. © 2007 Informa UK Ltd.

Saddam Hussein’s execution on Saturday December 31, 2006 and its broadcast over the internet in the form of video footage “leaked” by one of the bystanders constitutes a milestone of important geostrategic developments in the Middle East, mainly as a multiplier of the Shia-Sunni tension, between the followers of Moktanta al Sadr and the Sunnis, between the Shiites of Tehran and the Lebanese Muslims (Shiites and Sunnis). The execution also triggered a chain reaction of the Kurdish ethnic pockets in the area, starting with Iraqi Kurdistan. This reaction engages Turkey in the issue of geostrategic reshuffling in the area and provides its military regime with the opportunity to use this threat to achieve EU tolerance as regards the country’s accession process without having to implement the necessary adjustments stipulated by the “acquis communautaire” and without trying to clear the “Cyprus hurdle” in the course of the entry talks. Greece and Cyprus must adopt a coordinated approach at all levels to deal with this situation, in which even “hot conflict provocations” by Turkey against Greece, but also an increase of pressure from across the Atlantic directed against Levkosia and Athens, cannot be ruled out.

The Paros Island (Cyclades Islands, Aegean Sea, Greece) is characterized by a Mediterranean type of climate, while the Tihany Peninsula (Trans Danubian Middle Range Mountains, Lake Balaton, Hungary) is characterized by a Sub-Mediterranean type of climate. The Paros Island has abrupt rainfalls and lower temperatures during winters and long term sunshine accompanied by dry periods during the summer. The situation is similar in the Tihany Peninsula, except that there is snowfall in the winter and very intensive but short rainfalls in the summertime. These circumstances constitute a tough environment for the land. The low or sparse vegetation and steep slopes of the investigated areas leaves the ground exposed and very vulnerable to erosion. The recent change to the activities of the local people from agricultural to touristic ones and especially the abandonment of the agricultural terraces during the last 50 years has influenced the soil cover of the island, leading to total soil lossand exposure of the bedrock in many areas. The increase of tourist activities caused the same results however the agricultural activities have not ceased but increased a little. The slopes of the examined areas are high in general terms thus making soil regeneration almost impossible. The soil that is transferred is either moving towards the small alluvial plains of the island and inside the peninsula in Hungary. We try to compare the situation of the investigated Greek island and Hungarian peninsula bypointing out the areas that still appear to be in a high risk for erosion and to estimate the average amount of soil loss. For the later the Universal Soil Loss Equation (USLE) was tested on the data of the island. The application of the USLE took place with the use of MapInfo and ArcGIS Tools. We wish to give some details about the experiences of using the USLE model on these two territories.

The paper studies changes in daily precipitation records at the National Observatory, Athens, during the period 1891-2004. This is the longest available time series of precipitation for Greece. The results show that both the shape and scale parameter of a fitted two parameter gamma distribution for the last two decades do show a significant difference of these parameters, when compared to any previous period from the 1890s through the 1970s. Also important changes are observed in daily precipitation totals exceeding various thresholds such as 10, 20, 30 and 50 mm. More specifically, a negative trend in the number of wet days (remarkable after 1968) and a positive trend in extreme daily precipitation are evident. The changes of heavy and extreme precipitation events in this part of SE Europe have significant environmental consequences which cause considerable damage and loss of life.

This paper investigates the correlation between control and finiteness in Greek subjunctive clauses. It is shown that the main control pattern is Partial Control (PC) and that Exhaustive Control (EC) is very limited and occurs only with Anaphoric Subjunctives. On the basis of evidence from distribution and case agreement, it is claimed that Greek subjunctive T is finite, so that it always checks nominative case on the subject, even in EC constructions. It is therefore argued that control in Greek subjunctives cannot be accounted for by a PRO or a movement/Agree approach, because (i) the attested control pattern does not exhibit the properties of control as predicted by these approaches and (ii) their licensing conditions are not met. Additional crucial evidence is presented from constructions where control is attested over a lexical (either pronoun or DP) subject or even an object clitic. Thus, it is claimed that control in Greek subjunctive clauses is not the result of the licensing of the properties of their subject, but it derives from the licensing of their special temporal properties and from the semantic requirements of the main predicate.

{The authors determine from first principles the Curie temperature T-C for bulk Co in the hcp, fcc, bcc, and body-centered-tetragonal (bct) phases, for FeCo alloys, and for bcc and bct Fe. For bcc Co

FR258900 has been discovered as a novel inhibitor of human liver glycogen phosphorylase a and proved to suppress hepatic glycogen breakdown and reduce plasma glucose concentrations in diabetic mice models. To elucidate the mechanism of inhibition, we have determined the crystal structure of the cocrystallized rabbit muscle glycogen phosphorylase b-FR258900 complex and refined it to 2.2 angstrom resolution. The structure demonstrates that the inhibitor binds at the allosteric activator site, where the physiological activator AMP binds. The contacts from FR258900 to glycogen phosphorylase are dominated by nonpolar van der Waals interactions with Gln71, Gln72, Phe196, and Val45' (from the symmetry-related subunit), and also by ionic interactions from the carboxylate groups to the three arginine residues (Arg242, Arg309, and Arg310) that form the allosteric phosphate-recognition subsite. The binding of FR258900 to the protein promotes conformational changes that stabilize an inactive T-state quaternary conformation of the enzyme. The ligand-binding mode is different from those of the potent phenoxy- phthalate and acyl urea inhibitors, previously described, illustrating the broad specificity of the allosteric site.

The present contribution is dealing with the outcrops and the hydrogeological behaviour of the fractured rocks (mainly igneous, metamorphic and not karstified carbonate rocks, as they have been defined by the I.A.H Commission of the Hardrock Hydrogeology). The presentation starts with the description of the geotectonic regime of the Hellenic territory into the adopted different geotectoniczones. For each zone a general lithological and structural description is attempted accompanied by the description of the main aquifers and the general directions of the groundwater flow related to the formation of the rock mass fractures. Finally, an analytical description of some case studies is presented.

Free Choice Items (FCIs), such as French n’importe qui, Greek opjosdhipote and English anyone, are well known for their limited distributional properties. Most former analyses have been influenced by the polarity sensitivity tradition, accounting for the distribution of FCIs in terms of the conditions of licensing and anti­licensing by the semantics of a given context. Based on French, Greek and English data, this study proposes that FCIs occur in all contexts as long as their lexical semantics is compatible with both the semantics and the pragmatics of the context.Data, mostly extracted from the Free Choice Item Database constructed by the author, show that the majority of FCIs are grammatical in veridical contexts. Consequently, the condition of licensing does not apply to FCIs. FCIs express widening, indiscriminacy, indistinguishability, ignorance, indifference and low­level. These readings can be pragmatically blocked in all contexts. Widening, indiscriminacy, indifference and ignorance can be semantically blocked too. An FCI is ungrammatical if and only if all its readings are blocked. Consequently, the condition of anti­licensing does not apply to FCIs either, because it does not take into account the pragmatics of the context. The distribution of FCIs is, then, entirely free with the exception of certain cases in which semantic blocking is expected.This dissertation is of interest to researchers concerned with the study of FCIs, indefinites, definites and quantifiers, scholars working on more general issues concerning the semantics­pragmatics interface, and linguists interested in cross­linguistic and typological studies.

We report on the infrared transmission and light emission of Si-rich nitride (SRN) films prepared by low pressure chemical vapor deposition (LPCVD) from dichlorosilane (SiH2Cl2, DCS) and ammonia (NH3) mixtures. The main absorption band at about 830 cm- 1, attributed to Si-N vibration mode and observed in stoichiometric silicon nitride, shifted to slightly higher wavenumbers with increasing Si content in the SRN films. Annealing at temperatures higher than the deposition temperature induced a further shift of the main band to higher wavenumbers. Additionally, a new band appeared as a "shoulder" at about 1080 cm- 1, attributed to partial oxidation of the silicon nanocrystals. Photoluminescence (PL) obtained from the SRN films increased considerably and shifted to shorter wavelengths as the Si content decreased whereas annealing caused further enhancement and a slight shift to shorter wavelengths in comparison with the as-grown films. © 2007 Elsevier B.V. All rights reserved.

For a better understanding of the physical properties of semiconductor quantum dot ensembles, we have followed the behaviors of the transport and photoluminescence above, at, and below the percolation threshold of ensembles of Si quantum dots that are embedded in a Si O2 matrix. Our study revealed the roles of the interdot conduction, the single dot charging, and the connectivity in such systems. We conclude that while the first two determine the global transport, a connectivity dependent migration determines the coupling between the electrical and optical properties. © 2007 The American Physical Society.

Early genetic and physiological work in bacteria and fungi has suggested the presence of highly specific nucleobase transport systems. Similar transport systems are now known to exist in algae, plants, protozoa and metazoa. Within the last 15 years, a small number of microbial genes encoding nucleobase transporters have been cloned and studied in great detail. The sequences of several other putative proteins submitted to databases are homologous to the microbial nucleobase transporters but their physiological functions remain largely undetermined. In this review, genetic, biochemical and molecular data are described concerning mostly the nucleobase transporters of Aspergillus nidulans and Saccharomyces cerevisiae, the two model ascomycetes from which the great majority of data come from. It is also discussed as to what is known on the nucleobase transporters of the two most significant pathogenic fungi: Candida albicans and Aspergillus fumigatus. Apart from highlighting how a basic process such as nucleobase recognition and transport operates, this review intends to highlight features that might be applicable to antifungal pharmacology.

BACKGROUND: The purpose of this study was to evaluate gemcitabine- carboplatin (GCb) versus single-agent gemcitabine (G) in patients with advanced non-small cell lung cancer (NSCLC) and a performance status (PS) of 2. The primary endpoint was clinical benefit. PATIENTS AND METHODS: Patients were randomly assigned to either 1250 mg/m of G (arm A) or 1250 mg/m of G plus carboplatin area under the curve of 3 (arm B). Both treatments were given on days 1 and 14 and were repeated every 28 days for up to four cycles. RESULTS: Among the 90 eligible patients (47 in arm A and 43 in arm B), in arm A, two (4%) had partial responses (95% CI, 0.52%-14.5%) and 10 (21%) had stable disease (95% CI, 10.7%-35.7%). In arm B, six (14%) had partial responses (95% CI, 5.3%-27.9%) and nine (21%) had stable disease (95% CI, 10%-36%) (p = 0.14). No significant difference was found in terms of clinical benefit between the two treatment groups after two cycles of treatment or at the end of chemotherapy. Furthermore, no association was found between clinical benefit and response to treatment (p > 0.05). Median survival was 4.8 months (95% CI, 2.45-7.25) for arm A and 6.7 months (95% CI, 2.47-10.8) for arm B (p = 0.49). Neutropenia (p = 0.007) and thrombocytopenia (p < 0.001) were more common in group B. Nevertheless, no significant differences were found in terms of severe toxicities (p > 0.05 in all cases). CONCLUSION: No significant difference was found in terms of clinical benefit in patients with NSCLC and PS 2 who received single-agent G or GCb. Nevertheless, GCb caused more toxicity, particularly neutropenia and thrombocytopenia. © 2007International Association for the Study of Lung Cancer.

BACKGROUND: Although General Practice (GP) was recognized as a medical specialty in Greece in 1986, the number of GPs is insufficient to cover needs and only few medical graduates choose GP as a career option. In the present study we investigated the profile of medical students in terms of their decisions regarding specialization and the possible association of career choices different from GP with the status of undergraduate training regarding GP. METHODS: The sample consisted of final year students in the Medical School of the University of Athens, Greece. Students filled in a self-reported questionnaire focusing on medical specialization, and GP in particular. RESULTS: Response rate was 82.5% with 1021 questionnaires collected, out of 1237 eligible medical students. Only 44 out of the 1021 (4.3%) respondents stated that GP is -or could be- among their choices for specialty. The most popular medical specialty was General Surgery (10.9%), followed by Cardiology (9.6%), Endocrinology (8.7%) and Obstetrics-Gynaecology (8.3%). The most common criterion for choosing GP was the guaranteed employment on completion of the residency (54.6%) while a 56.6% of total respondents were positive to the introduction of GP/FM as a curriculum course during University studies. CONCLUSION: Despite the great needs, GP specialty is currently not a career option among undergraduate students of the greater Medical University in Greece and is still held in low esteem. A university department responsible for undergraduate teaching, promotion and research in GP (where not available) is essential; the status of undergraduate training in general practice/family medicine seems to be one of the most important factors that influence physician career choices regarding primary care specialties.

Korissia lagoon located in the southwest end of Corfu separated from the open Ionian Sea by a narrow (<250 m) stip of land. It has a surface of 4,2 km2 and depths <2m, communicating with the sea via an artificial-dredged channel. The bed of the lagoon consists of fine-grainned sediment (sandy silt – silty sand). Its drainage basin covers an area of 16 km2 and is characterized by low relief. It receives the freshwater inputs form a low relief (maximum elevation 319 m) of the drainage basin. The influx of fresh water is surficial includes also an underground flow, as indicated by the presence of a phreatic aquifer and a large number of wells at its nearby surrounding area. The water budget of the lagoon is characterised by a wet (October-March) and a dry (April-September) period. During the wet period the incoming volume of fresh water (5,3x106 m3 ) is much larger than its total volume (2,5 x 106 m3 ); this implies an outflow of lagoonal waters whilst lagoonal waters are characterised by relatively lower salinity values (<20 ppt) compare to those of the Ionian Sea (38 ppt). In contrast, during the dry period, the fresh water influx (1,2 x106 m3 ) is smaller than the volume of the lagoon; this induces an influx of sea water, which in association with the high levels of evaporation moduled hyper-saline (>50 ppt) hydrologic conditions within the lagoonal basin.

This chapter concerns the application of computing technologies in Geoarchaeology. The main issue is the combination of GIS and remote sensing technologies with on-site observations of the archaeological, geomorphological and geological characteristics of the area. This combination involves gathering all the necessary information of the spatial structures: geological, topographical, geomorphological and archaeological data. The main target is the composition of the palaeolandscape in order to reveal the paleotopography of Thera and the archaeological site of Akrotiri before the Minoan eruption. GIS analytical tools may help to recreate the different phases of landform evolution of Thera before the Minoan era till nowadays. Thus, 3D models before the Minoan, during the Minoan and after the Minoan phase were produced. Furthermore, the chapter focuses on the geomorphology of Akrotiri site, the most important archaeological site on Thera. The geological formations and the dominant erosion and deposition processes were mapped in order to understand the geomorphological evolution of the area. The extensive reworking and adaptation of the geomorphology from sustained volcanic activity over a long period has resulted in huge physical changes: loss of a central area of the island, coastline modifications, soil loss, deposition and abandonment of valleys and settlement sites. This abrupt evolution have played a major role to the land use change and land cultivation, strongly affecting the local communities, perhaps emphasising and coinciding with distinctive periods of cultural expansion and contraction.

In this paper we investigate the relations between the landforms and thediscontinuous tectonism. A multistep methodology has been adopted. Thus, first westudy the topography of a given area and by proper procedures we classify thegeoforms. We next examine the geological formations of the area, the drainagesystem, the landuse, the vegetation and the human impact.Finally, we study the tectonic zones of this area (faults and fractures zones). Datahas also been obtained by airphotos and satellite images. All the above information is analyzed in a G.I.S platform using expert system methodology. This procedure has been applied to some selected places of the Greek territory.

The Lebanon II war required the utmost attention, in foreign policy terms, from both Greece and Cyprus. This is because the conflict between Israel and Lebanon resulted in obvious dangers for the flaring up of all the national-state and ethnic actors in the region.

This paper is a geopolitical and geostrategic analysis of the Israel-Hezbollah asymmetric war. It also unveils how Iran and Syria influence the Middle East geostrategic subsystem and the Lebanon case.

This paper examines the lessons learned from the IsraelHezbollah war at a political and military level. It demonstrates the political benefits for Israel in security terms, and its military weak points. It also unveils how Iran and Syria influence the Middle East geostrategic subsystem and the Lebanon case, and suggests that a US attack against Iran is not realistic. It draws on valid evidence and statements by political figures from all involved parties.

In the present study the involvement of human activities is assessed in the revalorization of groundwater quality. The groundwater quality was assessed on the basis of physical and chemical analysis (electric conductivity, pH, total dissolved solids (TDS), total hardness, NO3 -, NO2 -, SO4 -2, Fe, Mn, Zn, Cu, B, residual sodium absorption (RSC) and sodium absorption ratio (SAR) for the period 2000-2004. From the analysis of results, it emerges that there are significant differences on the quality of water among the sample areas studied. The degradation of groundwater quality is mainly due to the pollution caused by the rural use of land, as well as its intensive exploitation. The salination and toxicity are potential problems of groundwater quality, especially in some areas, indicating that there is a need to take direct actions for the purpose of the optimum management of water resources in the Region of Thessaly. Β© 2007 Elsevier B.V. All rights reserved.

Despite the long lasting research the ideal method of reconstructing the ACL has not been found so far. The last year's attention has shifted to the use of the multistrand hamstring tendon grafts. High ultimate tensile load, multiple-bundle replacement that better approximates the anatomy of the normal ACL and low donor site morbidity are the main advantages of this ACL replacement graft. These theoretical advantages have been multiplied when surprisingly studies have shown that semitendinosus and gracilis tendons actually regenerate after harvesting for use as ACL autografts. In this review article we summarize the current knowledge concerning the hamstring regeneration and we focus on issues that have clinical relevance or issues that have not been answered so far.

Depressed cardiac Ca cycling by the sarcoplasmic reticulum (SR) has been associated with attenuated contractility, which can progress to heart failure. The histidine-rich Ca-binding protein (HRC) is an SR component that binds to triadin and may affect Ca release through the ryanodine receptor. HRC overexpression in transgenic mouse hearts was associated with decreased rates of SR Ca uptake and delayed relaxation, which progressed to hypertrophy with aging. The present study shows that HRC may mediate part of its regulatory effects by binding directly to sarco(endo)plasmic reticulum Ca-ATPase type 2 (SERCA2) in cardiac muscle, which is confirmed by coimmunostaining observed under confocal microscopy. This interaction involves the histidine- and glutamic acid-rich domain of HRC (320-460 aa) and the part of the NH(2)-terminal cation transporter domain of SERCA2 (74-90 aa) that projects into the SR lumen. The SERCA2-binding domain is upstream from the triadin-binding region in human HRC (609-699 aa). Specific binding between HRC and SERCA was verified by coimmunoprecipitation and pull-down assays using human and mouse cardiac homogenates and by blot overlays using glutathione S-transferase and maltose-binding protein recombinant proteins. Importantly, increases in Ca concentration were associated with a significant reduction of HRC binding to SERCA2, whereas they had opposite effects on the HRC-triadin interaction in cardiac homogenates. Collectively, our data suggest that HRC may play a key role in the regulation of SR Ca cycling through its direct interactions with SERCA2 and triadin, mediating a fine cross talk between SR Ca uptake and release in the heart.

We give an overview of [1], in collaboration with G. Skandalis, where we construct the holonomy groupoid and the C*-algebras associated with any singular foliation (in the sense of Stefan and Sussmann).

A cross-sectional study was carried out in healthy company employees from Greece with the aim of assessing the prevalence of human herpesvirus 8 (HHV-8) and identifying risk factors for this herpesviral infection. Serum samples obtained from 955 subjects were tested for antibodies to HHV-8 by the K8.1 enzyme-linked immunosorbent assay (ELISA). Associations between HHV-8 serostatus and potential risk factors were examined using t-test, chi square test, and multivariate logistic regression analysis. HHV-8 prevalence was 7.6% (95% confidence interval (CI): 6.0%, 9.5%) and it increased with age from 6.5% among <30 years old to 13.8% among > or =50 years old subjects (P = 0.006). HHV-8 seropositivity was independently associated with endoscopic examination (odds ratio (OR): 2.01; 95% CI: 1.09, 3.70; P = 0.026), HBsAg positivity (OR: 5.16; 95% CI: 2.02, 13.20; P = 0.001) and age (OR > or =50 years old vs. <50 years old: 2.09; 95% CI: 1.23, 3.52; P = 0.006). No statistically significant associations between HHV-8 positive status and gender, occupational status, surgery, transfusion, tattoos/body piercing, multiple sex partners, weakness/fatigue, HCV status were observed. HHV-8 is prevalent in Greece. The strong association between HBV infection and HHV-8 positive status supports the hypothesis of an association between these two viral infections. The association between HHV-8 seropositivity and endoscopic examination requires further investigation.

New BVRI CCD observations of the contact binary system HV~Aqr are presented. The new light curves are analyzed with the WD code and new geometric and photometric elements are derived. These elements are combined with the available spectroscopic data to yield the physical parameters of the system. The agreement between the spectroscopically and photometrically determined mass ratios of eclipsing binaries is also discussed.

The phononic band structure of two binary colloidal crystals, at hypersonic frequencies, is studied by means of Brillouin light scattering and analyzed in conjunction with corresponding dispersion diagrams of the single colloidal crystals of the constituent particles. Besides the acoustic band of the average medium, the authors’ results show the existence of narrow bands originating from resonant multipole modes of the individual particles as well as Bragg-type modes due to the (short-range) periodicity. Strong interaction, leading to the occurrence of hybridization gaps, is observed between the acoustic band and the band of quadrupole modes of the particles that occupy the largest fractional volume of the mixed crystal; the effective radius is either that of the large (in the symmetric NaCl-type crystalline phase) or the small (in the asymmetric NaZn13 -type crystalline phase) particles. The possibility to reveal a universal behavior of the phononic band structure for different single and binary colloidal crystalline suspensions, by representing in the dispersion diagrams reduced quantities using an appropriate length scale, is discussed.

In June 2005, the work of the EU Integrated Project EuroPrevall was started. EuroPrevall is the largest research project on food allergy ever performed in Europe. Major aims of the project are to generate for the first time reliable data on the prevalence of food allergies across Europe and on the natural course of food allergy development in infants. Improvement of in vitro diagnosis of food allergies is another important aim of the project. The present review summarizes current knowledge about the clinical presentation of food allergy and critically reviews available diagnostic tools at the beginning of the project period. A major problem in diagnosis is a relatively poor 'clinical specificity', i. e. both positive skin tests and in vitro tests for specific IgE are frequent in sensitized subjects without food allergy symptoms. So far, no in vitro test reliably predicts clinical food allergy. EuroPrevall aims at improving the predictive value of such tests by proceeding from diagnosis based on allergen extracts to purified allergen molecules, taking into account the affinity of the IgE-allergen interaction, and evaluating the potential of biological in vitro tests such as histamine release tests or basophil activation tests including assays performed with permanently growing cell lines.

Objectives.: Cervical cancer is a disease of middle-aged and elderly but still there are young women diagnosed with advanced disease that is incurable with local treatment and is treated with platinum-based combination chemotherapy. It is unknown whether these young patients have a poorer outcome compared to older patients or whether elderly patients have inferior outcome than younger patients when treated with combination chemotherapy. Methods.: We compared the outcome between young (< 35), elderly (> 70) and middle-aged (35-70) women who were treated with platinum-based combination chemotherapy for advanced, recurrent or persistent disease. Results.: Two hundred and eighteen patients were included in our database. The baseline clinical and disease characteristics were not different between age groups but anemia and thrombocytosis were more frequent in younger patients. Median survival for all patients was 13.4 (95%CI 11-15.8) months while survival of patients < 35 years of age was 9 months (95% CI 5.8-12), of patients older than 70 was 10 months (95% CI 6.9-13) of patients 35 to 70 years of age was 14.5 months (95% CI 11-18) (p = 0.004). Multiple factors were significant for survival in univariate analysis but only weight loss, pain score and relapse inside an irradiated filed were significant predictors of outcome in multivariate analysis. Conclusions.: Very young (< 35) and elderly (> 70) patients have a worse prognosis after treatment with combination chemotherapy for advanced or recurrent cervical cancer. Nevertheless, this difference is not significant when adjusted for other prognostic factors. © 2006 Elsevier Inc. All rights reserved.

OBJECTIVE: To characterize deficits in nonverbal recognition memory and functional brain changes associated with these deficits in Alzheimer disease (AD). METHODS: Using O-15 PET, we studied 11 patients with AD and 17 cognitively intact elders during the combined encoding and retrieval periods of a nonverbal recognition task. Both task conditions involved recognition of line drawings of abstract shapes. In both conditions, subjects were first presented a list of shapes as study items, and then a list as test items, containing items from the study list and foils. In the titrated demand condition, the shape study list size (SLS) was adjusted prior to imaging so that each subject performed at approximately 75% recognition accuracy; difficulty during PET scanning in this condition was approximately matched across subjects. A control task was used in which SLS = 1 shape. RESULTS: During performance of the titrated demand condition, SLS averaged 4.55 (+/-1.86) shapes for patients with AD and 7.53 (+/-4.81) for healthy elderly subjects (p = 0.031). However, both groups of subjects were closely matched on performance in the titrated demand condition during PET scanning with 72.17% (+/-7.98%) correct for patients with AD and 72.25% (+/-7.03%) for elders (p = 0.979). PET results demonstrated that patients with AD showed greater mean differences between the titrated demand condition and control in areas including the left fusiform and inferior frontal regions (Brodmann areas 19 and 45). CONCLUSIONS: Relative fusiform and inferior frontal differences may reflect the Alzheimer disease (AD) patients' compensatory engagement of alternate brain regions. The strategy used by patients with AD is likely to be a general mechanism of compensation, rather than task-specific.

OBJECTIVES: Health informatics is a well established and important multi-disciplinary and inter-disciplinary field that not only involves informatics but also medicine, nursing, engineering, biology and other-related subjects. The program has been organized on the basis of an inter-university approach with the participation of five Greek universities. The paper aims at providing a current description of the academic program and a preliminary evaluation of the implementation phase. METHODS: The paper presents a case study of a curriculum implementation from the phase of curriculum development to the phase of implementation and evaluation. Due to the interdisciplinary character of the course appropriate procedures were undertaken to ensure that mixed backgrounds can assimilate the broad spectrum of the teaching material taught. In the first stages of the implementation international students mainly from Europe attended the course. In addition, local graduates provided an extra dimension to the multi-layered difficulties and challenges of such a course implementation. RESULTS: The students registered in the course were from different backgrounds and disciplines. They were mainly from health sciences and engineering schools. The interdisciplinary arrangement of the course facilitated the proper exchange of thoughts, skills, and knowledge among and between students and teachers. CONCLUSIONS: The postgraduate course in health informatics at the University of Athens has now been running for more than fifteen consecutive years and is one of the first and longest standing courses in Europe. Continuous evaluation and adaptation is required to fit within the changing and evolving amazing field of biomedical and health informatics.

The in vitro utilization of biocompatible ferromagnetic nanoparticles (BFNs) in hemodialysis (HD), routinely used today for the treatment of end stage renal disease (ESRD), is introduced in this work. The proposed strategy is termed magnetically assisted hemodialysis (MAHD) and it aims to become a more efficient development of conventional HD. The method is based on the production of biocompatible ferromagnetic nanoparticles-targeted binding substances conjugates (BFNs-TBSs Cs) constructed of BFNs and specifically designed TBSs that should have high affinity and binding capacity for target toxic substances (TTSs) which must be removed from the ESRD patient subjected to HD. Antibodies or even specific proteins could serve as the TBS of the desired BFNs-TBSs Cs. The BFNs-TBSs Cs should be administered to the patient timely prior to the MAHD session so as to bind with the desired TTSs during their free circulation in the vascular network. Eventually, the complete BFNs-TBSs-TTSs structure can be selectively removed during the MAHD session by means of an external inhomogeneous magnetic field that is applied either at the dialyzer or at other collection point(s) along the blood circulation line of the dialysis machine. The advantages of MAHD over conventional HD regarding the patient's comfort and overall health status are discussed in detail among practical issues. To examine this proposition we employed Fe3O4 and bovine serum albumin (BSA) as the BFN and the TBS constituents respectively, since they are both highly biocompatible. By means of x-ray diffraction, atomic force microscopy, circular dichroism spectropolarimetry, UV-vis spectrophotometry, SQUID magnetometry, and nuclear magnetic resonance we evaluated (i) the structural/morphological characteristics, (ii) the magnetic retraction efficiency, and most importantly (iii) the toxin binding affinity and capacity of both bare Fe3O4 BFNs and Fe3O4-BSA Cs by performing in vitro experiments on specific TTSs. Homocysteine and p-cresol were chosen as representative TTSs and were investigated in great detail. The results obtained prove the in vitro applicability of the proposed MAHD method.

BACKGROUND: In North America and Europe, human immunodeficiency virus (HIV)-1 infection has typically been dominated by subtype B transmission. More recently, however, non-B subtypes have been increasingly reported in Europe. METHODS: We analyzed 1158 HIV-1-infected individuals in Greece by DNA sequencing and phylogenetic analyses of protease and partial reverse-transcriptase regions. RESULTS: We found that the prevalence of non-B subtypes has increased over time and that this significant trend can be mainly attributed to subtype A, which eventually surpassed subtype B in prevalence in 2004 (42% and 33%, respectively). Multivariate analysis revealed that the year of HIV diagnosis was independently associated with subtype A infection (odds ratio for being infected with subtype A for a 10-year increase in the time period of diagnosis, 2.09 [95% confidence interval, 1.36-3.24]; P<.001). Phylogenetic analysis revealed that the subtype A epidemic in Greece is the result of a single founder event. The date of the most recent common ancestor of the subtype A in Greece was estimated to be 1977.9 (95% highest posterior density interval, 1973.7-1981.9). CONCLUSIONS: Subtype A circulates among the long-term residents of Greece. This is in contrast to the situation in most European countries, in which infection with non-B genetic forms is associated either with being an immigrant or heterosexual or with intravenous drug use.

The synthesis of the C5' tert-butyl ketone of thymidine 1a and 2'-deoxyguanosine 2 is achieved by reaction of 5'-C-cyano derivatives with tert-butyl lithium followed by acid hydrolysis. The 5'R configuration is assigned by X-ray crystal structure determination of an opportunely protected derivative of 1a. The (5'S)-isomers of both nucleosides are not stable, and a complete decomposition occurs in the reaction medium. The photochemistry of 1a and 2 effectively produced the thymidin-5'-yl radical and the 2'-deoxyguanosin-5'-yl radical, respectively. In the thymidine system, the C5' radical is fully quenched in the presence of a physiological concentration of thiols. In the 2'-deoxyguanosine system, the C5' radical undergoes intramolecular attack onto the C8-N7 double bond of guanine leading ultimately to the 5',8-cyclo-2'-deoxyguanosine derivative. The cyclization of the 2'-deoxyguanosin-5'-yl radical occurs with a rate constant of ca. 1 x 10(6) s(-1) and is highly stereoselective affording only the (5'S)-diastereomer.

(Chemical Equation Presented) The synthesis of the C5′ tert-butyl ketone of thymidine 1a and 2′-deoxyguanosine 2 is achieved by reaction of 5′-C-cyano derivatives with tert-butyl lithium followed by acid hydrolysis. The 5′R configuration is assigned by X-ray crystal structure determination of an opportunely protected derivative of 1a. The (5′S)-isomers of both nucleosides are not stable, and a complete decomposition occurs in the reaction medium. The photochemistry of 1a and 2 effectively produced the thymidin-5′-yl radical and the 2′-deoxyguanosin-5′-yl radical, respectively. In the thymidine system, the C5′ radical is fully quenched in the presence of a physiological concentration of thiols. In the 2′-deoxyguanosine system, the C5′ radical undergoes intramolecular attack onto the C8-N7 double bond of guanine leading ultimately to the 5′,8-cyclo-2′-deoxyguanosine derivative. The cyclization of the 2′-deoxyguanosin-5′-yl radical occurs with a rate constant of ca. 1 × 106 s-1 and is highly stereoselective affording only the (5′S)-diastereomer. © 2007 American Chemical Society.

The purpose of this work is to assess, both experimentally and theoretically the status of air quality in a dentistry clinic of the Athens University Dentistry Faculty with respect to chemical pollutants and identify the indoor sources associated with dental activities. Total VOCs, CO2, PM10, PM2.5, NOx and SO2 were measured over a period of approximately three months in a selected dentistry clinic. High pollution levels during the operation hours regarding CO2, total VOCs and Particulate Matter were found, while in the non-working periods lower levels were recorded. On the contrary, NOx and SO2 remained at low levels for the whole experimental period. These conditions were associated with the number of occupants, the nature of the dental clinical procedures, the materials used and the ventilation schemes, which lead to high concentrations, far above the limits that are set by international organizations and concern human exposure. The indoor environmental conditions were investigated using the Computational Fluid Dynamics (CFD) model PHOENICS for inert gases simulation. The results revealed diagonal temperature stratification and low air velocities leading to pollution stratification, accompanied by accumulation of inert gaseous species in certain areas of the room. Different schemes of natural ventilation were also applied in order to examine their effect on the indoor comfort conditions for the occupants, in terms of air renewal and double cross ventilation was found to be most effective. The relative contribution of the indoor sources, which are mainly associated with indoor activities, was assessed by application of the Multi Chamber Indoor Air Quality Model (MIAQ) to the experimental data. It was found that deposition onto indoor surfaces is an important removal mechanism while a great amount of particulate matter emitted in the Clinic burdened severely the indoor air quality. The natural ventilation of the room seemed to reduce the levels of the fine particles. The emission rates for the fine and coarse particulates were found to be almost equal, while the coarse particles were found susceptible to deposition onto indoor surfaces. © 2007 Elsevier B.V. All rights reserved.

The vortex matter phase diagrams of aluminum doped Mg1-xAlxB2 crystals, deduced from local Hall ac-susceptibility (for H parallel to c axis) and bulk dc-magnetization measurements (for H parallel to c axis and ab plane) are reported. As in pristine and carbon doped MgB2, aluminum substituted crystals display the peak effect in the critical current. The peak effect is located very close to the H-c2(c)(T) line, while it disappears below a characteristic magnetic field H-* that depends on Al content. The absence of significant bulk pinning below the onset of the peak effect implies that the Bragg glass phase is present there. In some of the crystals the peak effect is not present as a sharp negative peak of the real part of the local ac susceptibility, but it appears as a negative double-peak feature. This observation may be related with the miscibility gap that occurs for 0.05 <= x <= 0.5. For low aluminum content the H-c2(c)(T) line lies slightly above the corresponding one of the pristine MgB2, but for higher aluminum content, T-c, H-c2(ab,c)(0), and anisotropy parameter gamma=H-c2(ab)(0)/H-c2(c)(0) take lower values when compared to pristine MgB2. Similarly with the pristine MgB2 crystals for the superconducting aluminum substituted crystals, the anisotropy parameter decreases monotonously as temperature increases as well. All the experimental observations could be qualitatively explained within the clean two-band approximation.

This study examined the effects of two resistive loads on fatigue during repeated sprints in children. Twelve 11.8 (0.2) year old boys performed a force-velocity test to determine the load (Fopt) corresponding to the optimal pedal rate. On two separate occasions, ten 6-s sprints interspersed with 24-s recovery intervals were performed on a friction-loaded cycle ergometer, against a load equal to Fopt or 50%Fopt. Although mean power output (MPO) was higher in the Fopt [397 (24) and 356 (19) W, P < 0.01], the decline in MPO over the 10 sprints was similar in Fopt [8.8 (1.9) %] and 50%Fopt [9.0 (2.4) %]. In contrast, peak power (PPO) was not different in sprint 1 between the two conditions [459 (24) and 460 (28) W], but was decreased only in 50%Fopt [11.4 (3.2) %, P < 0.01], while it was maintained in the Fopt despite the higher total work during each sprint. Fatigue within each sprint (percent drop from peak to end power output) was also higher in the 50%Fopt compared with the Fopt [32 (2.5) vs. 10 (1.6) %, P < 0.01]. Peak and mean pedal rate in Fopt condition were close to the optimum (Vopt), while a large part of the sprint time in 50%Fopt was spent far from Vopt. The present study shows that sprinting against Fopt reduces fatigue within and between repeated short sprints in children. It is suggested that fatigue during repeated sprints is modified when pedal rate is not close to Vopt, according to the parabolic power versus pedal rate relationship. © Springer-Verlag 2007.

This study examined the effects of two resistive loads on fatigue during repeated sprints in children. Twelve 11.8 (0.2) year old boys performed a force-velocity test to determine the load (Fopt) corresponding to the optimal pedal rate. On two separate occasions, ten 6-s sprints interspersed with 24-s recovery intervals were performed on a friction-loaded cycle ergometer, against a load equal to Fopt or 50%Fopt. Although mean power output (MPO) was higher in the Fopt [397 (24) and 356 (19) W, P < 0.01], the decline in MPO over the 10 sprints was similar in Fopt [8.8 (1.9) %] and 50%Fopt [9.0 (2.4) %]. In contrast, peak power (PPO) was not different in sprint 1 between the two conditions [459 (24) and 460 (28) W], but was decreased only in 50%Fopt [11.4 (3.2) %, P < 0.01], while it was maintained in the Fopt despite the higher total work during each sprint. Fatigue within each sprint (percent drop from peak to end power output) was also higher in the 50%Fopt compared with the Fopt [32 (2.5) vs. 10 (1.6) %, P < 0.01]. Peak and mean pedal rate in Fopt condition were close to the optimum (Vopt), while a large part of the sprint time in 50%Fopt was spent far from Vopt. The present study shows that sprinting against Fopt reduces fatigue within and between repeated short sprints in children. It is suggested that fatigue during repeated sprints is modified when pedal rate is not close to Vopt, according to the parabolic power versus pedal rate relationship. © Springer-Verlag 2007.

This study examined the effects of two resistive loads on fatigue during repeated sprints in children. Twelve 11.8 (0.2) year old boys performed a force-velocity test to determine the load (Fopt) corresponding to the optimal pedal rate. On two separate occasions, ten 6-s sprints interspersed with 24-s recovery intervals were performed on a friction-loaded cycle ergometer, against a load equal to Fopt or 50%Fopt. Although mean power output (MPO) was higher in the Fopt [397 (24) and 356 (19) W, P < 0.01], the decline in MPO over the 10 sprints was similar in Fopt [8.8 (1.9) %] and 50%Fopt [9.0 (2.4) %]. In contrast, peak power (PPO) was not different in sprint 1 between the two conditions [459 (24) and 460 (28) W], but was decreased only in 50%Fopt [11.4 (3.2) %, P < 0.01], while it was maintained in the Fopt despite the higher total work during each sprint. Fatigue within each sprint (percent drop from peak to end power output) was also higher in the 50%Fopt compared with the Fopt [32 (2.5) vs. 10 (1.6) %, P < 0.01]. Peak and mean pedal rate in Fopt condition were close to the optimum (Vopt), while a large part of the sprint time in 50%Fopt was spent far from Vopt. The present study shows that sprinting against Fopt reduces fatigue within and between repeated short sprints in children. It is suggested that fatigue during repeated sprints is modified when pedal rate is not close to Vopt, according to the parabolic power versus pedal rate relationship. © Springer-Verlag 2007.

We present the initial results from a deep HST survey of the nearby spiral galaxy M81 with the HST Advanced Camera for Surveys. The survey consists of B and V band observations of 29 ACS fields, totaling to 38 orbits. These observations, together with archival I-band ACS data, provide complete, deep coverage of the D25 area of the galaxy, down to 26-27 mag. This detection limit probes the bulk of early-type (O,B) stars and the population of star-clusters. The main goal of this survey is to characterize the X-ray source population of M81 in the context of its stellar populations and star-formation history. We discuss the analysis of the ACS data (mosaicing, astrometric registration, photometric analysis) and we present high quality images of the galaxy. We also discuss the initial results from the identification of optical counterparts to the X-ray sources detected in deep Chandra observations of M81, and the preliminary study of the stellar populations in individual fields of the galaxy. This work is supported by HST grant HST-GO-10584.01-A and NASA LTSA grant NAG-5-13056.

We report a randomised prospective study comparing two implants, the Gamma trochanteric nail and the ACE trochanteric nail, in the treatment of intertrochanteric femoral fractures in the elderly. One hundred and twelve patients were randomised on admission into two treatment groups. Fifty-six patients were treated with Gamma nail implants, and 56 were treated with ACE trochanteric nail. The average age of these patients was 78 years. Twenty fractures were stable and 92 unstable. The mean follow-up time was 8 months (6 -12). Regular clinical and radiological review was done 1, 3 and 6 months postoperatively. Operation time, fluoroscopy time, blood transfusion and complications were recorded. The mobility score was used to assess the pre-injury and postoperative mobility status. All the patients were treated within 36 h of their accident. There were no complications during surgery. All the patients were mobilised in the first 24 h postoperatively, regardless of the fracture type, and weight bearing was permitted as tolerated. Union of the fracture was achieved in all patients. There was no statistically significant difference between the two groups with regard to the studied parameters. There was no mechanical failure of the implants despite the early patient mobilisation. Early operation and early mobilisation resulted in a good functional outcome in all patients. Both the trochanteric gamma nail and ACE trochanteric nail provide effective methods of treatment for intertrochanteric fractures in elderly patients.

Because of the aging of the population, dementia has become a major public health problem. There has been growing evidence for a possible association between lipids and dementia. A large body of literature has demonstrated multiple hypothesized biologic links between lipids and neurodegenerative or other biologic pathways connected to dementing processes. However, the epidemiologic associations have been conflicting: dyslipidemia at middle age, but not in later life, seems to be associated with higher dementia risk in some but not all studies. Results from the Honolulu-Asia Aging Study reported by Saczynski et al. (Am J Epidemiol 2007;165:985-92) suggest that lipoprotein constituents, such as apolipoprotein A-I, a major component of the high density lipoprotein, may be more informative in enlightening the association between lipids and dementia. In this commentary, the epidemiology and biology of apolipoprotein A-I in relation to dementia is reviewed.

This study investigated the hypothesis that isotonic muscle performance following mild muscle damage would be disproportionately affected when measured at different parts of the range of motion. Seven male volunteers performed 50 maximal isometric contractions with the elbow flexors at a lengthened position. Maximal isotonic performance was measured before and for four days post-exercise at two parts of the range of motion of elbow flexion, including mainly the descending (L) or the ascending limb (S) of the angle-force curve. On day 1 post-exercise, muscle damage was evidenced by a decrease in peak isometric force (-20.3 ± 2.7%, p<0.01), a shift in optimum angle for force generation towards a greater elbow angle (by 0.12 ± 0.03 rad, p<0.05), and an increase in serum creatine kinase activity and muscle soreness (P<0.01). Isotonic performance indices were decreased only in the S condition (p<0.01). Shift in optimum angle and isotonic performance indices recovered on day 2. The disproportionate decrease in isotonic performance in the S condition may be explained by the shift of the optimum angle towards a longer muscle length, which would benefit force generation at elbow angles beyond the optimum angle but impair force at the more acute elbow angles. © 2007 - IOS Press and the authors. All rights reserved.

This study investigated the hypothesis that isotonic muscle performance following mild muscle damage would be disproportionately affected when measured at different parts of the range of motion. Seven male volunteers performed 50 maximal isometric contractions with the elbow flexors at a lengthened position. Maximal isotonic performance was measured before and for four days post-exercise at two parts of the range of motion of elbow flexion, including mainly the descending (L) or the ascending limb (S) of the angle-force curve. On day 1 post-exercise, muscle damage was evidenced by a decrease in peak isometric force (-20.3 ± 2.7%, p<0.01), a shift in optimum angle for force generation towards a greater elbow angle (by 0.12 ± 0.03 rad, p<0.05), and an increase in serum creatine kinase activity and muscle soreness (P<0.01). Isotonic performance indices were decreased only in the S condition (p<0.01). Shift in optimum angle and isotonic performance indices recovered on day 2. The disproportionate decrease in isotonic performance in the S condition may be explained by the shift of the optimum angle towards a longer muscle length, which would benefit force generation at elbow angles beyond the optimum angle but impair force at the more acute elbow angles. © 2007 - IOS Press and the authors. All rights reserved.

This study investigated the hypothesis that isotonic muscle performance following mild muscle damage would be disproportionately affected when measured at different parts of the range of motion. Seven male volunteers performed 50 maximal isometric contractions with the elbow flexors at a lengthened position. Maximal isotonic performance was measured before and for four days post-exercise at two parts of the range of motion of elbow flexion, including mainly the descending (L) or the ascending limb (S) of the angle-force curve. On day 1 post-exercise, muscle damage was evidenced by a decrease in peak isometric force (-20.3 ± 2.7%, p<0.01), a shift in optimum angle for force generation towards a greater elbow angle (by 0.12 ± 0.03 rad, p<0.05), and an increase in serum creatine kinase activity and muscle soreness (P<0.01). Isotonic performance indices were decreased only in the S condition (p<0.01). Shift in optimum angle and isotonic performance indices recovered on day 2. The disproportionate decrease in isotonic performance in the S condition may be explained by the shift of the optimum angle towards a longer muscle length, which would benefit force generation at elbow angles beyond the optimum angle but impair force at the more acute elbow angles. © 2007 - IOS Press and the authors. All rights reserved.

Study objective: To assess whether laparoscopy is a reliable technique for the investigation of women presenting with ascites and in whom the diagnosis remains obscure. Design: Prospective nonrandomized clinical study (Canadian Task Force classification II-2). Setting: University Departments of a tertiary referral center. Patients: Women presenting in our institution with ascites in whom the diagnosis remained obscure after an extensive nonoperative diagnostic work-up. Intervention: Undiagnosed cases were submitted to laparoscopy, and selective biopsy specimens were taken for histologic study. Measurements and main results: Over a 3-year period, 73 patients were admitted to our institution with diffuse ascites. In 9 patients (12.3%), the diagnosis remained obscure, and these patients were further investigated with laparoscopy. Selective biopsy specimens obtained at laparoscopy clarified the specific cause of the ascites in all 9 patients. Peritoneal carcinomatosis was responsible in 5 patients (a metastatic gastrointestinal tumor in 1 patient, a malignant mesothelioma of the peritoneum in 1 patient, and a serous papillary carcinoma of the peritoneum and of the ovary in 2 and 1 patients, respectively). Three patients were found with miliary peritoneal tuberculosis, and the last patient had an unusual peritoneal reaction to methylene blue after laparoscopic adhesiolysis. Conclusion: Laparoscopy is a valuable means of assessing the peritoneal cavity in patients with unexplained ascites, where the primary cause remains unclear. The diagnosis can be accurately made with selective biopsy specimens, and appropriate treatment can be instituted without delay. © 2007 AAGL.

BACKGROUND: High rates of leisure activity have been associated with reduced risk of Alzheimer disease (AD). OBJECTIVE: To determine whether prediagnosis leisure activity modifies the rate of cognitive decline in patients with AD. DESIGN: Inception cohort followed up longitudinally for a mean of 5.3 years (up to 13.9 years). SETTING: Urban community. PARTICIPANTS: A total of 283 patients with incident AD (mean age, 79 years; 56.2% Hispanic and 31.1% African American). MAIN OUTCOME MEASURES: Change in a composite cognitive score from diagnosis on and during the entire study follow-up. RESULTS: In multivariate-adjusted generalized estimating equation models of postdiagnosis change (n = 133), each leisure activity was associated with an additional yearly decline of 0.005 of a z-score unit in cognitive score (P = .17). In models expanded to include cognitive change during study follow-up, including evaluations before and after diagnosis (n = 283), each activity was associated with an additional yearly decline of 0.005 of a z-score unit in cognitive score (P = .03). The association was strongest for intellectual activities. CONCLUSIONS: Greater participation in prediagnosis leisure activities, especially intellectual activities, was associated with faster cognitive decline, supporting the hypothesis that the disease course in AD may vary as a function of cognitive reserve.

Background: Lenalidomide is a structural analogue of thalidomide with similar but more potent biologic activity. This phase 3, placebo-controlled trial investigated the efficacy of lenalidomide plus dexamethasone in the treatment of relapsed or refractory multiple myeloma. Methods: Of 351 patients who had received at least one previous antimyeloma therapy, 176 were randomly assigned to receive 25 mg of oral lenalidomide and 175 to receive placebo on days 1 to 21 of a 28-day cycle. In addition, all patients received 40 mg of oral dexamethasone on days 1 to 4, 9 to 12, and 17 to 20 for the first four cycles and subsequently, after the fourth cycle, only on days 1 to 4. Patients continued in the study until the occurrence of disease progression or unacceptable toxic effects. The primary end point was time to progression. Results: The time to progression was significantly longer in the patients who received lenalidomide plus dexamethasone (lenalidomide group) than in those who received placebo plus dexamethasone (placebo group) (median, 11.3 months vs. 4.7 months; P<0.001). A complete or partial response occurred in 106 patients in the lenalidomide group (60.2%) and in 42 patients in the placebo group (24.0%, P<0.001), with a complete response in 15.9% and 3.4% of patients, respectively (P<0.001). Overall survival was significantly improved in the lenalidomide group (hazard ratio for death, 0.66; P = 0.03). Grade 3 or 4 adverse events that occurred in more than 10% of patients in the lenalidomide group were neutropenia (29.5%, vs. 2.3% in the placebo group), thrombocytopenia (11.4% vs. 5.7%), and venous thromboembolism (11.4% vs. 4.6%). Conclusions: Lenalidomide plus dexamethasone is more effective than high-dose dexamethasone alone in relapsed or refractory multiple myeloma. (ClinicalTrials.gov number, NCT00424047.) Copyright © 2007 Massachusetts Medical Society.

In this study we report on the light-emission characteristics of Si nanocrystals formed at the initial stages of anodization of bulk crystalline Si in the transition regime using extremely short pulses of anodic current. A considerable enhancement and a red-shift of the photoluminescence (PL) peak of the as-grown films under prolonged laser illumination in atmosphere was observed. Ageing or thermal oxidation in atmosphere at 300 °C caused similar red-shift and significant enhancement of PL relative to the as-grown films. In all cases the enhancement and the red-shift of the PL coincided with the appearance of O2-Si-H2 and O2-Si-H(OH) stretching modes in the Fourier-Transform-Infra-Red (FTIR) absorption spectra. Oxidation in dry oxygen at 900 °C caused red-shift of PL without enhancement. Finally removal of the oxide caused blue shift of PL. All these observations are discussed in the context of the quantum confinement model. © 2007 WILEY-VCH Verlag GmbH & Co. KGaA.

Context: Classical novae are quite frequent in M 31. However, very few spectra of M 31 novae have been studied to date, especially during the early decline phase. Aims: Our aim is to study the photometric and spectral evolution of a M 31 nova event close to outburst. Methods: Here, we present photometric and spectroscopic observations of M31N 2005-09c, a classical nova in the disk of M 31, using the 1.3 m telescope of the Skinakas Observatory in Crete (Greece), starting on the 28th September, i.e. about 5 days after outburst, and ending on the 5th October 2005, i.e. about 12 days after outburst. We also have supplementary photometric observations from the La Sagra Observatory in Northern Andalucía, Spain, on September 29 and 30, October 3, 6 and 9 and November 1, 2005. The wavelength range covered by the spectra is from 3565 Å to 8365 Å. The spectra are of high S/N allowing the study of the evolution of the equivalent widths of the Balmer lines, as well as the identification of non-Balmer lines. Results: The nova displays a typical early decline spectrum that is characterized by many weak Fe II multiplet emissions. It is classified as a Pfe nova. From the nova light curve, we have also derived its speed class, t_2=14±2.5 days. As the nova evolved the Balmer lines became stronger and narrower. The early decline of the expansion velocity of the nova follows a power law in time with an exponent of ≃-0.2.

We present numerical simulations of axisymmetric, magnetically driven relativistic jets. Our special-relativistic, ideal-magnetohydrodynamics numerical scheme is specifically designed to optimize accuracy and resolution and to minimize numerical dissipation. In addition, we implement a grid-extension method that reduces the computation time by up to three orders of magnitude and makes it possible to follow the flow up to six decades in spatial scale. To eliminate the dissipative effects induced by a free boundary with an ambient medium we assume that the flow is confined by a rigid wall of a prescribed shape, which we take to be z ~ ra (in cylindrical coordinates, with a ranging from 1 to 3). We also prescribe, through the rotation profile at the inlet boundary, the injected poloidal current distribution: we explore cases where the return current flows either within the volume of the jet or on the outer boundary. The outflows are initially cold, sub-Alfvénic and Poynting flux-dominated, with a total-to-rest-mass energy flux ratio μ ~ 15. We find that in all cases they converge to a steady state characterized by a spatially extended acceleration region. The acceleration process is very efficient: on the outermost scale of the simulation as much as ~ 77 per cent of the Poynting flux has been converted into kinetic energy flux, and the terminal Lorentz factor approaches its maximum possible value (Γ∞ ~= μ). We also find a high collimation efficiency: all our simulated jets (including the limiting case of an unconfined flow) develop a cylindrical core. We argue that this could be the rule for current-carrying outflows that start with a low initial Lorentz factor (Γ0 ~ 1). Our conclusions on the high acceleration and collimation efficiencies are not sensitive to the particular shape of the confining boundary or to the details of the injected current distribution, and they are qualitatively consistent with the semi-analytic self-similar solutions derived by Vlahakis and Königl. We apply our results to the interpretation of relativistic jets in active galactic nuclei: we argue that they naturally account for the spatially extended accelerations inferred in these sources (Γ∞ >~ 10 attained on radial scales R >~ 1017cm) and are consistent with the transition to the matter-dominated regime occurring already at R >~ 1016cm.

We present numerical simulations of axisymmetric, magnetically driven relativistic jets. Our special-relativistic, ideal-magnetohydrodynamics numerical scheme is specifically designed to optimize accuracy and resolution and to minimize numerical dissipation. In addition, we implement a grid-extension method that reduces the computation time by up to three orders of magnitude and makes it possible to follow the flow up to six decades in spatial scale. To eliminate the dissipative effects induced by a free boundary with an ambient medium we assume that the flow is confined by a rigid wall of a prescribed shape, which we take to be z ~ ra (in cylindrical coordinates, with a ranging from 1 to 3). We also prescribe, through the rotation profile at the inlet boundary, the injected poloidal current distribution: we explore cases where the return current flows either within the volume of the jet or on the outer boundary. The outflows are initially cold, sub-Alfvénic and Poynting flux-dominated, with a total-to-rest-mass energy flux ratio μ ~ 15. We find that in all cases they converge to a steady state characterized by a spatially extended acceleration region. The acceleration process is very efficient: on the outermost scale of the simulation as much as ~ 77 per cent of the Poynting flux has been converted into kinetic energy flux, and the terminal Lorentz factor approaches its maximum possible value (Γ∞ ~= μ). We also find a high collimation efficiency: all our simulated jets (including the limiting case of an unconfined flow) develop a cylindrical core. We argue that this could be the rule for current-carrying outflows that start with a low initial Lorentz factor (Γ0 ~ 1). Our conclusions on the high acceleration and collimation efficiencies are not sensitive to the particular shape of the confining boundary or to the details of the injected current distribution, and they are qualitatively consistent with the semi-analytic self-similar solutions derived by Vlahakis and Königl. We apply our results to the interpretation of relativistic jets in active galactic nuclei: we argue that they naturally account for the spatially extended accelerations inferred in these sources (Γ∞ >~ 10 attained on radial scales R >~ 1017cm) and are consistent with the transition to the matter-dominated regime occurring already at R >~ 1016cm.

The magnetic and dielectric properties of the Ni2 FeV3 O11-6 compound synthesized using different annealing routes have been studied by means of static magnetization, electron paramagnetic resonance and dielectric spectroscopy. The temperature dependence of the magnetic susceptibility has shown marked singularities due to the coexistence of many kinds of magnetic interactions. Dielectric measurements have shown a second order phase transition to the ferroelectric state at about 200K. Dielectric loss measurements have shown an intense peak at the same temperature with activation energy of about 0.42 eV. All investigated compounds of the M-Fe-V-O (M=Ni, Zn, Mg) system have displayed a slight anomaly of the EPR parameters at about 200K. This anomaly is interpreted as arising from the competition between different magnetic subsystems preventing the formation of a long-range magnetic order. © 2007 Advanced Study Center Co. Ltd.

The magnetic properties of the site ordered multicomponent vanadate Mg3 Fe4 (V O4) 6 are studied using dc magnetization and electron paramagnetic resonance (EPR) measurements. The static susceptibility shows antiferromagnetic interactions between Fe3+ spins with a Curie-Weiss temperature =-111 (1) K, while a transition to a spin-glass-like state is observed at T≈8.5 K, indicating appreciable spin frustration. EPR measurements corroborate the presence of antiferromagnetically coupled Fe3+ spins from high temperatures, while a distinct change in the temperature variation of the EPR parameters is observed at T<80 K, complying with the mean-field energy scale provided by the Curie-Weiss temperature of the system. The resulting magnetic inhomogeneity that persists despite the absence of cation disorder between magnetic and diamagnetic metal ions is attributed to the presence of small amounts of oxygen deficiency that modifies the connectivity and superexchange coupling between Fe3+ spins and leads to a disordered magnetic ground state. © 2007 American Institute of Physics.

We examine a quantum dot (QD) illuminated in the near field with subwavelength spatial resolution, while simultaneously it is subjected to a magnetic field of variable orientation and magnitude. The magnetic field orientation can conserve or destroy the zero-magnetic-field ("structural") symmetry. The asymmetry induced by the magnetic field -except for specific orientations along symmetry axes- can be uncovered in the near-field (NF) but not in the far-field (FF) spectra. We predict that NF magnetoabsorption experiments of realistic spatial resolution could reveal the QD symmetry. This exceptional symmetry-resolving power of the near-field optics, is lost in the far field.

In this study we investigated the magneto-transport properties of the ohmic contact between polycrystal-line NiMnSb thin films grown by pulsed laser deposition and n-type degenerate InSb (100) substrates. An unusual negative giant magnetoresistance (n-GMR) effect is found when the external magnetic field is parallel to the in-plane current direction. A similar effect is also observed when Ni films are deposited on InSb substrates. On the other hand, no n-GMR effect is displayed when the deposited film is nonmagnetic. Grazing-incidence X-ray reflectometry shows the formation of a low-density NiMnSb layer at the interface. The presence of such a layer coincides with the appearance of the n-GMR. We argue that the n-GMR effect is due to magnetic precipitates formed at the interface during the growth of the magnetic films. We propose that these precipitates align their magnetic moments in the direction of the external magnetic field and thus, the spin dependent scattering of the electrons is reduced. The effect of these precipitates on the magnetoresistance depends on the thermal processing of the system. © 2007 WILEY-VCH Verlag GmbH & Co. KGaA.

Studies of bortezomib, thalidomide, and lenalidomide have shown promising clinical activity in relapsed/refractory multiple myeloma (MM). Bortezomib alone and in combination with other agents is associated with high response rates, consistently high rates of complete response, and a predictable and manageable profile of adverse events. Thalidomide-based regimens have also shown substantial clinical activity. The accumulating experience from ongoing trials of bortezomib/lenalidomide/dexamethasone combinations in patients who have relapsed/refractory or newly diagnosed MM will provide critical information that will determine the possible role of this combination as the basic backbone for combination regimens for management of advanced MM. © 2007 Elsevier Inc. All rights reserved.

Viral infections of the respiratory tract are the most common precipitants of acute asthma exacerbations. Exacerbations are only poorly responsive to current asthma therapies and new approaches to therapy are needed. Viruses, most frequently human rhinoviruses (RV), infect the airway epithelium, generate local and systemic immune responses, as well as neural responses, inducing inflammation and airway hyperresponsiveness. Using in vitro and in vivo experimental models the role of various proinflammatory or anti-inflammatory mediators, antiviral responses and molecular pathways that lead from infection to symptoms has been partly unravelled. In particular, mechanisms of susceptibility to viral infection have been identified and the bronchial epithelium appeared to be a key player. Nevertheless, additional understanding of the integration between the diverse elements of the antiviral response, especially in the context of allergic airway inflammation, as well as the interactions between viral infections and other stimuli that affect airway inflammation and responsiveness may lead to novel strategies in treating and/or preventing asthma exacerbations. This review presents the current knowledge and highlights areas in need of further research.

BACKGROUND: We previously reported that the Mediterranean diet (MeDi) is related to lower risk for Alzheimer disease (AD). Whether MeDi is associated with subsequent AD course and outcomes has not been investigated. OBJECTIVES: To examine the association between MeDi and mortality in patients with AD. METHODS: A total of 192 community-based individuals in New York who were diagnosed with AD were prospectively followed every 1.5 years. Adherence to the MeDi (0- to 9-point scale with higher scores indicating higher adherence) was the main predictor of mortality in Cox models that were adjusted for period of recruitment, age, gender, ethnicity, education, APOE genotype, caloric intake, smoking, and body mass index. RESULTS: Eighty-five patients with AD (44%) died during the course of 4.4 (+/-3.6, 0.2 to 13.6) years of follow-up. In unadjusted models, higher adherence to MeDi was associated with lower mortality risk (for each additional MeDi point hazard ratio 0.79; 95% CI 0.69 to 0.91; p = 0.001). This result remained significant after controlling for all covariates (0.76; 0.65 to 0.89; p = 0.001). In adjusted models, as compared with AD patients at the lowest MeDi adherence tertile, those at the middle tertile had lower mortality risk (0.65; 0.38 to 1.09; 1.33 years' longer survival), whereas subjects at the highest tertile had an even lower risk (0.27; 0.10 to 0.69; 3.91 years' longer survival; p for trend = 0.003). CONCLUSION: Adherence to the Mediterranean diet (MeDi) may affect not only risk for Alzheimer disease (AD) but also subsequent disease course: Higher adherence to the MeDi is associated with lower mortality in AD. The gradual reduction in mortality risk for higher MeDi adherence tertiles suggests a possible dose-response effect.

BACKGROUND: Higher adherence to the Mediterranean diet (MeDi) has been related to lower Alzheimer's disease risk. Some dietary factors have been studied in patients with essential tremor (ET), but the MeDi's effect has not been investigated. METHODS: Adherence to the MeDi was calculated from a food frequency questionnaire administered in a case-control study of environmental epidemiology of ET in the New York Tri-State area. Logistic regression models were used to examine whether adherence to the MeDi predicted ET (vs. control) outcome. The models adjusted for age, gender, ethnicity, education, caloric intake, body mass index, smoking, ethanol consumption, coffee intake and blood harmane concentrations. RESULTS: 148 ET cases adhered less to MeDi (0-9 scale with higher scores indicating higher adherence) than 250 controls (mean 4.3 +/- 1.7 vs. 4.7 +/- 1.7; p = 0.03). Higher adherence to MeDi was associated with lower odds for ET [0.78 (0.61-0.99); p = 0.042]. As compared to subjects at the lowest MeDi adherence tertile, those at the middle tertile had lower ET odds [0.41 (0.16-1.05)], while subjects at the highest tertile had an even lower ET odds [0.29 (0.10-0.82); p for trend 0.021]. CONCLUSIONS: Compared to controls, ET cases adhered less to MeDi. The gradual reduction in ET odds with higher MeDi adherence tertiles suggests a possible dose-response effect. The mechanisms that underlie this association merit further study.

Background and Objectives: As new therapeutic options for multiple myeloma (MM) emerge, identification of biological markers which could predict clinical response to standard treatment with high-dose melphalan (HDM) supported by autologous stem cell transplantation (ASCT) becomes more important. Design and Methods: Melphalan-induced damage formation and repair of monoadducts and interstrand cross-links in the p53 gene were studied in peripheral blood mononuclear cells obtained from 32 patients prior to therapy. The same studies were performed in the peripheral blood cells of these patients immediately after subsequent HDM administration. Clinical response and time to progression were correlated with molecular end-points obtained in vitro. Results: Values for all molecular end-points examined in vitro were highly correlated with the respective in vivo results within individual patients. All in vitro end-points indicative of increased DNA damage and slower repair capacity were predictive of a favorable response to HDM; the area under the curve of total adducts (AUC-TA) had the highest predictive ability. Using the cut-off value of 736 adducts/106 nucleotides x h for the AUC-TA, the positive predictive value for clinical response to HDM was 100%. Moreover, patients with an AUC-TA equal to or higher than this cut-off value had significantly longer times to progression than had patients with an AUC-TA lower than the cut-off value (hazard ratio 0.19; 95% confidence intervals 0.06 to 0.60). Interpretation and Conclusions: An in vitro assay to quantify melphalan-induced p53-specific damage formation/repair can be used to select those patients with MM who are more likely to benefit from HDM supported by ASCT. ©2007 Ferrata Storti Foundation.

The trend in silicon photonics, in the last few years has been to reduce waveguide size to obtain maximum gain in the real estate of devices as well as to increase the performance of active devices. Using different methods for the modulation, optical modulators in silicon have seen their bandwidth increased to reach multi GHz frequencies. In order to simplify fabrication, one requirement for a waveguide, as well as for a modulator, is to retain polarisation independence in any state of operation and to be as small as possible. In this paper we provide a way to obtain polarisation independence and improve the efficiency of an optical modulator using a V-shaped pn junction base on the natural etch angle of silicon, 54.7 deg. This modulator is compared to a flat junction depletion type modulator of the same size and doping concentration. © 2007 Optical Society of America.

Minichromosome maintenance proteins (MCM) have recently emerged as novel proliferation markers with prognostic implications in several tumour types. This is the first study investigating MCM-2 and MCM-5 immunohistochemical expression in a series of ovarian adenocarcinomas and low malignant potential (LMP) tumours aiming to determine possible associations with clinicopathological parameters, the conventional proliferation index Ki-67, cell cycle regulators (p53, p27Kip1, p21WAF1 and pRb) and patients' outcome. Immunohistochemistry was applied in a series of 43 cases of ovarian LMP tumours and 85 cases of adenocarcinomas. Survival analysis was restricted to adenocarcinomas. The median MCM-2 and MCM-5 labelling indices (LIs) were significantly higher in adenocarcinomas compared to LMP tumours (P<0.0001 for both associations). In adenocarcinomas, the levels of MCM-2 and MCM-5 increased significantly with advancing tumour stage (P=0.0052 and P=0.0180, respectively), whereas both MCM-2 and MCM-5 increased significantly with increasing tumour grade (P=0.0002 and P=0.0006, respectively) and the presence of bulky residual disease (P<0.0001 in both relationships). A strong positive correlation was established between MCM-2 or MCM-5 expression level and Ki-67 LI (P<0.0001) as well as p53 protein (P=0.0038 and P=0.0500, respectively). Moreover, MCM-2 LI was inversely correlated with p27Kip-1 LI (P=0.0068). Finally, both MCM-2 and MCM-5 were associated significantly with adverse patients' outcome in both univariate (≥20 vs >20%, P=0.0011 and ≥25 vs <25%, P=0.0100, respectively) and multivariate (P=0.0001 and 0.0090, respectively) analysis. An adequately powered independent group of 45 patients was used in order to validate our results in univariate survival analysis. In this group, MCM-2 and MCM-5 expression retained their prognostic significance (P<0.0001 in both relationships). In conclusion, MCM-2 and MCM-5 proteins appear to be promising as prognostic markers in patients with ovarian adenocarcinomas. © 2007 Cancer Research UK.

In the present study, an attempt is made to assess the atmospheric boundary-layer (ABL) depth over an urban area, as derived from different ABL schemes employed by the mesoscale model MM5. Furthermore, the relationship of the mixing height, as depicted by the measurements, to the calculated ABL depth or other features of the ABL structure, is also examined. In particular, the diurnal evolution of ABL depth is examined over the greater Athens area, employing four different ABL schemes plus a modified version, whereby urban features are considered. Measurements for two selected days, when convective conditions prevailed and a strong sea-breeze cell developed, were used for comparison. It was found that the calculated eddy viscosity profile seems to better indicate the mixing height in both cases, where either a deep convective boundary layer develops, or a more confined internal boundary layer is formed. For the urban scheme, the incorporation of both anthropogenic and storage heat release provides promising results for urban applications. © Springer Science+Business Media, B.V. 2007.

Observations of collimated outflows in young stellar objects indicate that several features of the jets can be understood by adopting the picture of a two-component outflow wherein a central stellar component around the jet axis is surrounded by an extended disk-wind. The precise contribution of each component may depend on the intrinsic physical properties of the YSO and also its evolutionary stage. In this context, we study a numerical model based on such a two-component outflow by using as an initial condition a combination of two prototypical models, each describing a meridionally self-similar and a radially self-similar exact solution of the steady-state, ideal hydromagnetic equations. These two classes of radially and meridionally self-similar solutions, have already been well studied and have been found to be related to the properties of disk- and stellar-wind, respectively. By properly mixing the two solutions, a variety of models is constructed with different contribution weights for each component in the initial set-up. The models are evolved in time by using the PLUTO code and the interaction and co-existence of the two components in the jet is investigated. It is found that a steady-state is always reached, independently of the mixing parameters of the two model ingredients. Moreover, the final outcome of the time evolution stays rather close to the initial analytical solutions. The results are compared and discussed along the lines of recent observational data.

Drug absorption is a complex process dependent upon drug properties such as solubility and permeability, formulation factors, and physiological variables including regional permeability differences, pH, luminal and mucosal enzymes, and intestinal motility, among others. Despite this complexity, various qualitative and quantitative approaches have been proposed for the estimation of oral drug absorption. These approaches are reviewed in this article with particular emphasis on drug dissolution modelling, dynamic systems for oral absorption and absorption models based on structure. The regulatory aspects of oral drug absorption and in particular the biopharmaceutic classification of drugs are also discussed. Models for drug dissolution and release describe adequately the in vitro data, and models for oral drug absorption provide reasonable results. The development of in vitro-in vivo correlations based on the official compendia specifications are facilitated using commercial computer packages.

We use Monte Carlo simulations in order to study diffusion controlled drug release from matrices consisting of random mixtures of high and low diffusivity areas (random mixing), and from matrices covered by a thin film of low diffusivity (ordered mixing). We compared our results with the Weibull model for drug release and found that it provides an adequate description of the release process in all cases of random mixing and most cases of ordered mixing. We have studied the dependence of the Weibull parameters on the diffusion coefficient and, in most cases, found a rather simple linear dependence. Moreover, our results indicate that a device covered by a thin film with diffusion coefficient three orders of magnitude lower that the coefficient of the rest of the device, will release drug at constant rate for most of the release process. This last result may have considerable practical applications. (C) 2007 Elsevier B.V. All rights reserved.

INTRODUCTION: Prediction of soft-tissue outline shape from skeletal remains is useful in forensics and archaeology. The inverse problem, the assessment of underlying skeletal relationships from the external appearance, is pertinent in orthodontics. The purposes of this study were to assess the correlation between craniofacial shape and shape of the soft-tissue profile outline and to determine the extent to which it might be possible to predict the latter from the former. METHODS: Lateral cephalograms from 170 consecutive orthodontic patients were used, and 17 skeletal, 2 dental, and 22 soft-tissue landmarks were digitized and processed by using Procrustes superimposition and principal component analysis. The principal components of the skeletal and soft-tissue shapes were entered into the correlation analysis. RESULTS: Significant correlations were found between the skeletal and the soft-tissue components. The use of 7 anterior skeletal landmarks (not including the nasal bone) resulted in a predictive power (coefficient of determination) of 38% of the variability of soft-tissue shape. This increased to almost 50% by adding nasal and incisor points but showed only a slight further improvement by incorporating posterior skeletal landmarks. CONCLUSIONS: Anterior skeletal and dental landmarks can be used to predict soft-tissue profile shape with a 50% power in children and adolescents.

INTRODUCTION: Soft-tissue facial outline has been studied by conventional cephalometric methods, and differences between the 2 sexes have been identified, mainly related to size and timing of growth. However, shape per se was not sufficiently evaluated, especially regarding variability, age-related changes, and sexual dimorphism. The purpose of this study was to evaluate shape variability and sexual dimorphism of the soft-tissue outline by using morphometric methods. METHODS: Pretreatment lateral cephalograms from 170 consecutive patients (82 male, 88 female) aged 7 to 17 years were used. Fifteen skeletal and 22 soft-tissue landmarks were digitized and processed with Procrustes superimposition and principal component analysis. The principal components (PCs) of the soft-tissue shape were analyzed in relation to age and sex. RESULTS: The first 8 PCs explained approximately 90% of the total shape variability. The first coefficient (PC1) related to lip, nose, and chin prominence and included 36% of total shape variability. It was significantly correlated to age, but with a low coefficient of determination (r2 = 13%). The second coefficient (PC2) related to facial convexity and explained 18% of shape variability. The next 2 coefficients were mainly related to lower lip shape. Statistically significant sexual dimorphism was detected, but the overall shape differences between the average profiles of boys and girls were minor and barely detectable visually. Shape dimorphism was present both before and after the age of 12 years. CONCLUSIONS: Shape variability related mainly to relative lip protrusion, convexity of the face, and lower lip shape. Shape differences between the sexes seemed to exist even before the pubertal growth spurt, but they were small. Age changes in shape appeared more significant.

Bone disease is one of the most debilitating manifestations of multiple myeloma. A complex interdependence exists between myeloma bone disease and tumor growth, creating a vicious circle of extensive bone destruction and myeloma progression. Proteasome inhibitors have recently been shown to promote bone formation in vitro and in vivo. Preclinical studies have demonstrated that proteasome inhibitors, including bortezomib, which is the first-in-class such agent, stimulate osteoblast differentiation while inhibiting osteoclast formation and bone resorption. Clinical studies are confirming these observations. Bortezomib counteracts the abnormal balance of osteoclast regulators (receptor activator of nuclear factor-κB ligand and osteoprotegerin), leading to osteoclast inhibition and decreased bone destruction, as measured by a reduction in markers of bone resorption. In addition, bortezomib stimulates osteoblast function, possibly through the reduction of dickkopf-1, leading to increased bone formation, as indicated by the elevation in bone-specific alkaline phosphatase and osteocalcin. The effect of bortezomib on bone disease is thought to be direct and not only a consequence of the agent's antimyeloma properties, making it an attractive agent for further investigation, as it may combine potent antimyeloma activity with beneficial effects on bone. However, the clinical implication of these effects requires prospective studies with specific clinical end points. © 2007 by The American Society of Hematology.

Encouraged by the latest experimental developments as well as by the theoretical interest on the near‐field (NF) optics of semiconductor quantum dots (QDs), we present our most recent theoretical results on the NF optical absorption and photoluminescence (PL) of single and coupled III‐V QDs subjected additionally to an external magnetic field of variable orientation and magnitude. The zero‐magnetic‐field “structural” QD symmetry can be destroyed varying the magnetic field orientation. The asymmetry induced by the magnetic field ‐except for specific orientations along symmetry axes‐ can be uncovered in the near‐field but not in the far‐field spectra. Hence, we predict that NF magnetoabsorption experiments, of realistic spatial resolution, will be in the position to bring to light the QD symmetry.

BACKGROUND: Numerous studies have implicated neurogenesis in the hippocampus in animal models of depression, especially those related to controllability and learned helplessness. Here, we tested the hypothesis that uncontrollable but not controllable stress would reduce cell proliferation in the hippocampus of male and female rats and would relate to the expression of helplessness behavior. METHODS: To manipulate controllability, groups of male and female rats were trained in one session (acute stress) or over seven sessions (repeated stress) to escape a footshock, whereas yoked control subjects could not escape but were exposed to the same amount of stress. Cell proliferation was assessed with immunohistochemistry of bromodeoxyuridine (BrdU) and immunofluorescence of BrdU and neuronal nuclei (NeuN). Separate groups were exposed to either controllable or uncontrollable stress, and their ability to learn to escape during training on a more difficult task was used as a behavioral measure of helplessness. RESULTS: Acute stress reduced cell proliferation in males but did not affect proliferation in the female hippocampus. When animals were given the opportunity to learn to control the stress over seven days, males produced more cells than the yoked males without control. Repeated training with controllable stress did not influence proliferation in females. Under all conditions, males were more likely than females to express helplessness behavior, even males that were not previously stressed. CONCLUSIONS: The modulation of neurogenesis by controllability was evident in males but not in females, as was the expression of helplessness behavior, despite the fact that men are less likely than women to experience depression.

Previous research has shown that some associative learning tasks prevent the death of new neurons in the adult hippocampus. However, it is unclear whether it is mere exposure to the training stimuli that rescues neurons or whether successful learning of the task is required for enhanced neuronal survival. If learning is the important variable, then animals that learn better given the same amount of training should retain more of the new cells after learning than animals that do not learn as well. Here, we examined the effects of training versus learning on cell survival in the adult hippocampus. Animals were injected with BrdU to label a population of cells and trained one week later on one of two trace conditioning tasks, one of which depends on the hippocampus and one that does not. Increases in cell number occurred only in animals that acquired the learned response, irrespective of the task. There were significant correlations between acquisition and cell number, as well as between asymptotic performance and cell number. These data support the idea that learning and not simply training increases the survival of the new cells in the hippocampus.

AIM: The aim of this study was to investigate the relationship between the activation level of certain protagonist muscles of the upper and lower body during the shot-put with the shot-put performance in skilled athletes. METHODS: Eight experienced right-handed shot-putters, performed the shot-put with the linear technique. They also performed a maximum (1RM) squat and a 1RM incline bench-press strength test. Electromyographic (EMG) signals were recorded from the m. quadriceps vastus lateralis (VL), m. gastrocnemius internus, m. pectoralis major (PEC) and the m. triceps brachii (TRI) of the right side during all efforts. The level of EMG during the shot-put was normalized relatively to that measured during the respective maximum strength test. RESULTS: Shot-put performance was significantly correlated with 1RM squat (r=0.76, P<0.05) and 1RM bench-press (r=0.75, P<0.05) as well as with the average EMG from VL and PEC after taking the power position (r=0.91, P<0.01 and r=0.75, P<0.05, respectively). A close negative relationship was also found between shot-put performance and the time to reach peak activation of right TRI during the explosive strike of the throwing arm (r=-0.70, P<0.05). CONCLUSION: These results suggest that, besides the importance of absolute muscle strength, an important parameter for shot-put performance is the level of activation of the VL and the PEC during the delivery phase. Furthermore, these data suggest that the TRI should be activated fast in order to be an effective contributor to the shot-put performance.

Social capital is a key component in understanding the relationship between European sport governing bodies and civil society. A core concept in sociology, political science, organizational behaviour and business, social capital is relatively new in the context of European sport governance. In exploring the boundaries of both sport and social capital in theory and practice, one can see sport as a form of positive social capital that promotes social cohesion, trust, social ties, etc. However, it could also be perceived as «dark» socialcapital since the politics of sport do not always deliver the social benefits they proclaim due to the «exclusionary» vs. inclusive factors: commercialization, doping, institutionalized gender personification, the leaky pipeline and the glassceiling in SGBs and in competitive sports. Sport has not yet evolved into a form of social capital which can be nurtured and reproduced to raise social cohesion and eliminate social exclusions.KEY WORDS: sport as social capital, «dark» social capital insports, social capital production/reproduction, gender personificationin sports, leaky pipeline and glass ceiling.

Social capital is a key component in understanding the relationship between European sport governing bodies and civil society. A core concept in sociology, political science, organizational behaviour and business, social capital is relatively new in the context of European sport governance. In exploring the boundaries of both sport and social capital in theory and practice, one can see sport as a form of positive social capital that promotes social cohesion, trust, social ties, etc. However, it could also be perceived as ・・dark・・ social capital since the politics of sport do not always deliver the social benefits they proclaim due to the ・・exclusionary・・ vs. inclusive factors: commercialization, doping, institutionalized gender personification, the leaky pipeline and the glass ceiling in SGBs and in competitive sports. Sport has not yet evolved into a form of social capital which can be nurtured and reproduced to raise social cohesion and eliminate social exclusions.

We report the discovery of an optical nova in M31 on four consecutive dithered R filter CCD images (each with 100 sec exposure) obtained on 2007 July 25.92564, 25.92714, 25.92865, 25.93015 with corresponding R magnitudes of 18.1, 18.2, 18.1, 18.1 obtained at the 1.3m f/7.5 telescope at Skinakas Observatory, Crete, Greece, using an Andor DZ436-BV CCD Camera. The position obtained for the nova candidate is RA(2000) = 00 42 43.29 , Dec(2000) = +41 17 44.10 with an accuracy of 0.2".

We report the discovery of an optical nova candidate in M 31 on ten stacked R filter CCD images (each with 60 sec exposure) obtained on 2007 Aug 30.018 with an R magnitude of 17.8 obtained at the 60cm f/8 Ganymed telescope located at Skinakas Observatory, Crete, Greece, using a ST10XME CCD Camera. The object is confirmed on CCD images with the same telescope using a broad H-alpha filter (4*120 s stacked, 17.7 mag) obtained on 2007 Aug 30.029.

We report the discovery of an optical nova candidate in the outer disk of M 31 on nine stacked R filter images (each with 60 sec exposure) and four stacked 12nm H-alpha filter images (each with 120 sec exposure) on 2007 Aug 24.081 and 24.093 with a magnitude of 18.7 in R and 18.1 in H-alpha, respectively. The images were obtained at the 60cm f/3 Ganymed telescope located at Skinakas Observatory, Crete, Greece, using a STL11000M CCD Camera.

We report the discovery of an optical nova in M31 at RA(2000) = 00h 42m 59.49s , Dec(2000) = +41° 15' 06.5" with an accuracy of 0.2". The observations were obtained at the 1.3m Ritchey Chretien f/7.5 telescope at Skinakas Observatory, Crete, Greece, using an Andor DZ436-BV CCD Camera (with a Marconi 2k x 2k chip with 13.5µm sq. pixels). The observations were taken through a Johnson standard R filter (4*100 s stacked) and a broad H- alpha filter (3*300 s stacked).

We report the discovery of a optical nova in M31 on four consecutive dithered R filter CCD images obtained on (2007 July 19.00741, 19.00890, 19.01041, 19.01193, with corresponding R magnitudes of 18.8, 18.7, 18.8, 18.5) obtained at the 1.3m Ritchey Chretien f/7.5 telescope at Skinakas Observatory, Crete, Greece, using an Andor DZ436-BV CCD Camera (with a Marconi 2k x 2k chip with 13.5µm sq. pixels).

The Korringa-Kohn-Rostoker Green-function method for noncollinear magnetic structures was applied on Mn and Cr nanoclusters deposited on the Ni(111) surface. We consider various dimers, trimers, and tetramers. We obtain collinear and noncollinear magnetic solutions, brought about by the competition of antiferromagnetic interactions. It is found that the triangular geometry of the Ni(111) substrate, together with the intracluster antiferromagnetic interactions, is the main cause of the noncollinear states, which are secondarily affected by the cluster-substrate exchange interactions. The stabilization energy of the noncollinear, compared to the collinear, states is calculated to be typically of the order of 100 meV/atom, while multiple local-energy minima are found, corresponding to different noncollinear states, differing typically by 1-10 meV/atom. Open structures exhibit sizable total moments, while compact clusters tend to have very small total moments, resulting from the complex frustration mechanisms in these systems.

Abstract [18156-74-6] C6H12N2Si (MW 140.29) InChI = 1S/C6H12N2Si/c1-9(2,3)8-5-4-7-6-8/h4-6H,1-3H3 InChIKey = YKFRUJSEPGHZFJ-UHFFFAOYSA-N (silylating agent for alcohols and 1,3-dicarbonyl compounds; reaction with esters to give imidazolides; preparation of O-trimethylsilyl monothioacetals; aromatization of the A-ring of steroids) Physical Data: bp 93–94 °C/14 mmHg; fp 5 °C; d 0.956 g cm−3. Form Supplied in: liquid. Handling, Storage, and Precautions: flammable. Harmful by inhalation, in contact with skin, and if swallowed. Possible carcinogen. Use in a fume hood. When using, wear protective gear and clothing. Handle and store under N2. Store in a cool dry place.

The nuclear magnetic moment of the ground state of 57 Cu(I? = 3/2-, T1/2 = 196.3 ms) has been measured to be ?(57Cu) = (2.00 ± 0.05) ?N using the ?-NMR technique. Together with the known magnetic moment of the mirror partner 57Ni, the spin expectation value was extracted as ?? ?z? = -0.78 ± 0.13. Discrepancy between present results and shell model calculations in the full fp shell implies significant shell breaking at 56Ni with the neutron number N = 28. © EDP Sciences/Societe? Italiana di Fisica/Springer-Verlag 2007.

Intermediate-energy heavy-ion collisions can produce a spin polarization of the projectile-like species. Spin polarization has been observed for both nucleon removal and nucleon pickup processes. Qualitative agreement with measured spin polarization as a function of the momentum of the projectile-like fragment is found in a kinematic model that considers conservation of linear and angular momentum and assumes peripheral interactions between the fast projectile and target. Better quantitative agreement was reached by including more realistic angular distributions and deorientation caused by ?-ray emission and by correcting for the out-of-plane acceptance. The newly introduced corrections were found to apply to both nucleon removal and nucleon pickup processes. © 2007 The American Physical Society.

Intermediate-energy heavy-ion collisions can produce a spin polarization of the projectile-like species. Spin polarization has been observed for both nucleon removal and nucleon pickup processes. Qualitative agreement with measured spin polarization as a function of the momentum of the projectile-like fragment is found in a kinematical model that considers conservation of linear and angular momentum and assumes peripheral interactions between the fast projectile and target. Improvements to the kinematical model are discussed that aim to achieve quantitative agreement with spin polarization data from both the nucleon removal and pickup processes. © 2007 American Institute of Physics.

An investigation of the optical properties of Si-rich silicon nitride films prepared by low pressure chemical vapor deposition (LPCVD) from dichlorosilane (SiH2Cl2, DCS) and ammonia (NH3) mixtures has been performed. From TEM analysis, it was found that the excess Si forms nanocrystals the size of which depends on the temperature. The real and the imaginary part of the refractive index of the films were calculated using spectroscopic ellipsometry by fitting the ellipsometric data in the range 1000-250 nm using the Tauc-Lorentz model. It was found that the optical constants of the films mainly depend on their chemical composition which can be controlled by the DCS/NH3 flow ratio. Annealing at temperatures up to 1100 °C for 4 h does not considerably affect the refractive index of the films. Depending on their stoichiometry and the annealing conditions applied after growth, some of the films emitted light in the visible at room temperature. This was attributed to the quantum confinement of carriers in the Si nanocrystals contained in the films. © 2007 Elsevier Ltd. All rights reserved.

We report the discovery of a possible nova in M31 on four consecutive dithered stacked R filter CCD images, obtained on 2007 September 02.09, with the 1.3m Ritchey Chretien f/7.5 telescope at Skinakas Observatory, Crete, Greece, using an Andor DZ436-BV CCD Camera (with a Marconi 2k x 2k chip with 13.5µm sq. pixels). The R magnitude of the object was 18.1. On 2007 September 03.09, the object was again detected with the same instrument setup, with an R magnitude of 18.2.

Standardized allergen extracts are needed for diagnosis and therapy purposes. For grapes, standardization is hampered by low protein and high tannin and pectin concentrations. The aim of the current study was to develop an optimized method for the extraction of grape proteins and possibly extend this to other fruits. Several existing or modified extraction methods were compared by means of protein concentration determination, SDS-PAGE, immunoblotting and radioallergosorbent test (RAST). An optimized extraction protocol was obtained in which we combined a high concentration of plant tissue, a concentrated, enriched and neutral buffer able to remove sugars and keep proteins soluble and a bivalent buffer for pectin removal. Both the quantitative (protein concentration) and qualitative parameters (SDS-PAGE protein patterns and IgE reactivity) were compared to standard protocols and commercial extracts used as diagnostic tools in the clinical practice. This method proved to be the most efficient mainly compared to the standard Björksten protocol in extracting the low molecular weight proteins, including the major grape allergen (lipid transfer protein, Vit v 1). It proved to be an easy, low cost and reproducible method proposed to prepare grape extracts that could replace the commercially available ones, used for diagnosis and possibly extend the method to other fruits especially in extracting LTPs.

The aim of this study was the outcome of Fowler-Stephens (FS) operations in prepubertal Wistar rats. Thirty-two 30-day-old rats underwent laparoscopic FS procedures on the right testicles (8 of them formed the control group). Nine, 30, 70, and 90 days later we assessed the testes histologically and determined inhibin betaB serum concentrations; 1 day earlier, ultrasonography was also performed. Decreases in central testicular vascularity and heterogeneous parenchymal echogenicity were the initial sonographic evidence of testicular damage, which either regressed in time or extended toward the periphery. Early degenerative changes either remained mild and restricted in the germinative epithelium or became more severe, affecting additional structures. Decreases in the seminiferous tubule area, thickening of the tunica albuginea, and increases in the number of mast cells were changes that reached significance. Significant decreases in the amount of serum inhibin betaB were also found, and the decreases correlated significantly with both the thickening of the tunica albuginea and the increases in the number of mast cells but not with the decreases in the seminiferous tubule area. Division of the spermatic vessels caused severe testicular degeneration as evidenced by changes in ultrasonographic and histologic features combined with drops in the levels of serum inhibin betaB.

{Our study examined if dietary long-chain polyunsaturated fatty acids (LCPUFA) have an impact on oxidative stress in preterm infants. Serum malonyldialdehyde (MDA), total peroxide concentrations, and total antioxidant capacity were determined at mean (standard deviation [SD]) 34.7 (10.9) days of life in 104 healthy preterm infants (gestational age, 32.6 [2.9] weeks; birthweight; 1605 [285] g) who were randomly assigned to be fed since birth either a formula containing LCPUFA (arachidonic and docosahexaenoic) (group A

 

Saint John Chrysostom is an eminent ecumenical teacher of Christianity. Modern research displays undiminished interest in his pedagogic techniques. John Chrysostom considers the in-structive sufficiency of memory as a crucial element of his ped-agogic interventions. He always intends to incise the content of his preachings on the memory of the congregation. According to his teachings, the use of memory for educational purposes reduces to divine initiative and human goodwill. Saint John is a shepherd, focused on his human flock and their human lives. The mnemonic impressions he uses in his speeches are de-rived from life itself: universal memories, arisen by the existen-tial background, related with the “ἀρχέγονο κάλλος” of the soul, the beauty which was lost, as well as Paradise, because of the original sin. Saint John tries to keep the memory of God alive and endeavours to unmask death in the oblivious pathways of human mind. He is a reminiscent of the lost sight of Angels and the holy lives of Saints. As a shepherd of souls, he is persis-tent to reveal the devil and his traps and lead his flock towards a constant reference to the “neighbour”, who must be loved as oneself, so that the eschatological memory of the Final Crisis could produce a realistic impact in society. His pedagogic ob-jective is not exhausted in a “gnoseological” level, or in other words, in a plain memorization of all kinds of information, such as biblical topics, and their interpretations, opinions of other Fathers, historical events, environmental aspects, socio-econo-mic phenomenons, customs, properties of ancient Greek, as well as universal Mythology, Philosophy, Technology and Sci-ence. Neither was his preaching limited to a practical level, such as the acceptance and conceptualization of moral and dogmatic lessons. John Chrysostom proves to be a great developer of experien-tial memory and a perceptive master of its exploitation in the fields of moral conscience. Being aware of the important role that memory plays in the process of learning, and particularly in Christian catechesis, he devises and applies various mnemonic techniques so as to expand and improve the mnemonic ability of the congregation. His erudition and scholarship support his immanent pedagogic talent. In his works, ancient-Greek and Jewish-Christian tradition in teaching methods are exploited in a most brilliant way. Mnemonic or “Mnemotechnia” renders the processes and techniques which lead to growth, expansion and strengthening of memorization and recollection skills. For Saint John “mne-motechnia” is a procedure, which is activated before the preach-ing and lasts long after the end of it. Chrysostomic speech is full of inventive and charming subterfuges, which maintain the in-terest and attention of the listener undiminished. There is no doubt that this kind of mnemonic amplifies the theological knowledge of the audience.· however, in this book, “mne-motechnia” is evaluated as a reinforcing operation which aims to the renovating prospect of preaching. Chrysostomic speech, beyond the authentic messages that conveys, accomplishes to “capture” the listener via “trapping” the memory of his moral conscience. Saint John knows how to develop mnemonically his peda-gogic methods, relatively with a) the suitable preparation of the congregation, so as to be ready and eager to listen and accept the preaching, b) the suitable space and time (or even the fre-quency) and, above all, the most competent dexterities in con-veying and adopting the messages of God. Thus, Chrysostom, through his works proposes to the potential lecturer or preacher the model of rational delimitation and instructive presentation of the preaching materials, as well as, the organization of teach-ing, the clarity of the messages and last but not least the “moth-er of learning”: repetition. To the listeners, Chrysostom recom-mends the regular and systematic follow-up of preaching, to-gether with certain practical sense-kinetic techniques, as well as concentration and prayer.Speaking is an art, which, when it is truly charismatic, can create strong feelings and emotions of admiration and joy. Chrysostom establishes his mnemonic methods on audibility and visualization. In other words, the visual pedagogic models function mainly in acoustic and facial level. The acoustic mne-monic techniques include semasiological and echo-instrumental forms of speaking. Visual mnemonic techniques presuppose vividness in speaking, combined with a vast number of figura-tive examples (visual models).

The Messinian pre-evaporitic sedimentary succession of Gavdos Island (Metochia section) is a nearly uninterrupted succession of marine sediments, dominated by finely laminated diatomaceous marls, which are cyclically alternating with clayey diatomites and white diatomites. The qualitative and quantitative analysis of the planktonic foraminiferal fauna allowed the recognition of nine bioevents, which have been astronomically dated for the Mediterranean. The base of the diatomitic succession in Gavdos Island is dated at 6.722Ma and the top at 6.015Ma. The studied section contains benthic foraminiferal genera characteristic of an outer shelf to slope environment. The qualitative and quantitative analysis of this microfauna revealed three benthic foraminiferal fossil assemblages and the occurrence of allochthonous species transported into the bathyal environment by current activity. The cyclical pattern of the benthic foraminifera assemblages indicates that the studied sediments have been affected by repeated episodes of basin restriction characterized by low diversity benthic foraminifera populations, and a limited planktonic foraminifer association typified by shallow, surface-dwelling forms. This restriction was partly due to Antarctic cooling, which produced palaeo-Mediterranean sea-level oscillations during the Early Messinian, as a prelude to closure of the Atlantic connections. The relative impact of climatic versus tectonic control on sedimentation patterns within this basin is discussed. Résumé Les sédiments marins du Messinien pré-évaporitique de l’île de Gavdos (coupe de Metochia) sont quasi continus et dominés par des marnes diatomitiques finement laminées alternant de façon cyclique avec des diatomites argileuses et des diatomites blanches. L’analyse qualitative et quantitative de la faune de foraminifères planctoniques a permis la mise en évidence de neuf événements biologiques qui ont été datés par l’astrochronologie à l’échelle de la Méditerranée. La base de la succession diatomitique de l’île de Gavdos date de 6,722Ma et son sommet de 6,015Ma. La coupe contient des genres de foraminifères benthiques caractéristiques d’un environnement allant de la plate-forme externe au talus. L’analyse qualitative et quantitative de cette microfaune révèle trois assemblages de foraminifères benthiques et la présence d’espèces allochtones apportées dans le domaine bathyal par l’activité des courants. Le caractère cyclique des assemblages de foraminifères benthiques indique que ces sédiments ont été affectés par des épisodes répétés de confinement du bassin caractérisés par la faible diversité des populations de foraminifères benthiques et une association restreinte de foraminifères planctoniques marquée par des formes affectionnant les habitats de surface dans des eaux de faible profondeur. Ce confinement était en partie dû au refroidissement antarctique qui entraîna des oscillations du niveau marin de la Méditerranée pendant le Messinien inférieur en prélude à la fermeture des corridors de connexion avec l’océan Atlantique. Les impacts relatifs des forçages du climat et de la tectonique sur les processus sédimentaires dans ce bassin sont discutés.

Cerebral white matter lesions (WML) are present in more than 50% of patients with osteonecrosis of the femoral head (ONFH). Paraoxonase 1 (PON1) gene product is a detoxifying and pesticide metabolizing enzyme. Genetic variants of the PON1 gene have been found to influence the occurrence and progression of WML. We examined whether two PON1 polymorphisms (M55L and R192Q) are associated with ONFH and influence the occurrence of WML. We studied 104 patients with ONFH and 113 healthy age- and sex-matched subjects. We used logistic regression models to examine associations and survival analyses (Cox proportional hazards models) to examine possible influence of alleles on age at onset of ONFH. We found no association of PON1 M55L alleles and genotypes with ONFH. The distribution of PON1 Q192R alleles (p = 0.001) and genotypes (QQ vs. QR/RR) (p = 0.004) were statistically different between controls and patients. Patients with QQ genotype had six times higher risk for WML at brain MRI (adjusted OR 5.95; 95% CI 1.30-27.03; p = 0.02). In Cox models, there was a significant association of allele Q with risk for ONFH indicating a possible dose effect (HR = 1.43; 95%CI = 1.04-1.97; p for trend = 0.03). We conclude that individuals with PON1 192QQ genotype may have increased risk for ONFH and WMLeOn.

BACKGROUND AND OBJECTIVE: Non-steroidal anti-inflammatory drugs are considered as an effective treatment of postoperative pain after laparoscopic cholecystectomy. COX-2 inhibitors are newer drugs having less adverse effects. Data supporting their efficacy postoperatively in comparison to older non-steroidal anti-inflammatory drugs are scarce. Our study is a prospective, randomized, double-blinded, placebo-controlled trial comparing the efficacy of lornoxicam vs. parecoxib for the management of pain after laparoscopic cholecystectomy. MATERIALS AND METHODS: We enrolled 76 patients, ASA I and II, scheduled for elective laparoscopic cholecystectomy. The patients were randomized to receive before induction parecoxib 40 mg i.v., lornoxicam 8 mg i.v. or placebo. Pain at rest and on movement was assessed using a visual analogue scale at 0, 6, 12 h postoperatively. Total meperidine consumption and adverse effects were also recorded. RESULTS: At 12 h, visual analogue scale scores at rest and on movement were significantly lower with parecoxib and lornoxicam compared with control ( P = 0.047). The percentage of patients needing meperidine and the average dose of meperidine administered was significantly lower with parecoxib and lornoxicam compared with control (P < 0.001 and P = 0.018). There was no difference between parecoxib and lornoxicam. One patient receiving lornoxicam vomited. CONCLUSIONS: Parecoxib 40 mg i.v. and lornoxicam 8 mg i.v. were equianalgesic and both were more efficacious than placebo for the management of pain after laparoscopic cholecystectomy.

BACKGROUND AND AIM OF THE STUDY: Prosthetic heart valve dysfunction impacts on morbidity and quality of life. Although the diagnosis can be made by imaging studies, clinical symptoms commonly precede the diagnostic work-up. The ThromboCheck device analyzes the sound frequency spectra of valve motion, and alterations due to valve dysfunction are observed before overt clinical symptoms develop. The study aim was to determine if the ThromboCheck can be used to monitor the prosthetic valve function of patients at home. METHODS: Between 2003 and 2007, a total of 541 prosthetic heart valve recipients was prospectively enrolled into a double-blind, multi-center study. ThromboCheck devices were used to evaluate the sound frequency phenomena of valve motion. If the sound frequency spectra deviated from baseline, alarm signals were returned to the medical center via telephone, and these prompted evaluation by fluoroscopy and echocardiography. The clinical follow up included questionnaires at regular intervals. RESULTS: The cumulative observation period exceeded 748 patient-years, with a median follow up of 25.2 months per patient (range: 1 to 36 months). Almost all patients used the device at least two to three times per week to evaluate valve function, and the vast majority found it easy to operate. About 135,000 codes were returned to the study centers for further analysis; of these codes, 30 (0.0002%) were alarm signals. On 29 of the 30 occasions, prosthetic valve dysfunction was confirmed by fluoroscopy and echocardiography, yielding positive predictive values and specificities of 97% and 100%, respectively. There was no clinical event in the absence of a ThromboCheck alarm signal. Thrombolysis or increased warfarin-based anticoagulation quickly restored the initial sound frequency spectrum of the prosthetic valve in 16 patients. Another 13 patients were surgically revised; their prosthetic valves revealed significant thrombi upon replacement. By using the ThromboCheck device as part of a surveillance system, 79% of the patients felt safer with regards to prosthetic valve dysfunction. CONCLUSION: Analysis of sound frequency spectra by the ThromboCheck identified prosthetic heart valve dysfunction before clinical symptoms developed, and promoted early therapy. The restoration of valve function normalized the frequency spectra, which may be utilized to guide treatment. These results justify further efforts to introduce the analysis of sound phenomena into routine clinical care after prosthetic valve implantation.

Muscle differentiation requires the transition from motile myoblasts to sessile myotubes and the assembly of a highly regular contractile apparatus. This striking cytoskeletal remodelling is coordinated with a transformation of focal adhesion-like cell-matrix contacts into costameres. To assess mechanisms underlying this differentiation process, we searched for muscle specific-binding partners of paxillin. We identified an interaction of paxillin with the vinexin adaptor protein family member ponsin in nascent costameres during muscle differentiation, which is mediated by an interaction of the second src homology domain 3 (SH3) domain of ponsin with the proline-rich region of paxillin. To understand the molecular basis of this interaction, we determined the structure of this SH3 domain at 0.83 A resolution, as well as its complex with the paxillin binding peptide at 1.63 A resolution. Upon binding, the paxillin peptide adopts a polyproline-II helix conformation in the complex. Contrary to the charged SH3 binding interface, the peptide contains only non-polar residues and for the first time such an interaction was observed structurally in SH3 domains. Fluorescence titration confirmed the ponsin/paxillin interaction, characterising it further by a weak binding affinity. Transfection experiments revealed further characteristics of ponsin functions in muscle cells: All three SH3 domains in the C terminus of ponsin appeared to synergise in targeting the protein to force-transducing structures. The overexpression of ponsin resulted in altered muscle cell-matrix contact morphology, suggesting its involvement in the establishment of mature costameres. Further evidence for the role of ponsin in the maintenance of mature mechanotransduction sites in cardiomyocytes comes from the observation that ponsin expression was down-regulated in end-stage failing hearts, and that this effect was reverted upon mechanical unloading. These results provide new insights in how low affinity protein-protein interactions may contribute to a fine tuning of cytoskeletal remodelling processes during muscle differentiation and in adult cardiomyocytes.

The gut hormone peptide YY 3-36 [PYY (3-36)] has been suggested to posses anorexigenic actions in animals and human adults. However, its circulating concentrations and function have not been studied in neonates. Serum concentrations of PYY (3-36) were determined by RIA (RIA) in 62 healthy preterm infants [mean(SD) gestational age, 32.0(2.1) weeks; postnatal age, 40.9(14.8 d)] and 15 healthy fullterm infants of comparable postnatal age and gender. The correlations between PYY (3-36) levels and anthropometric characteristics, food intake, growth rates and circulating concentrations of total PYY, ghrelin, leptin, insulin and adiponectin were examined. Mean (SD) PYY (3-36) concentrations were higher in preterm [543.7(157.6) ng/L) than full term infants [350.9(114.1) ng/L; p < 0.001) and accounted for 48% and 42% of total PYY basal plasma immunoreactivity in preterm and full term infants, respectively. In multiple regression analysis, PYY (3-36) concentrations correlated negatively with the infants’ BMI and positively with serum ghrelin concentrations, but not with caloric intake, weight gain or concentrations of any other hormone studied. In conclusion, PYY (3-36) represents almost half of total PYY immunoreactivity in neonates. It’s correlations with ghrelin and BMI suggest a role of this peptide in the regulation of energy homeostasis; however, its specific functions and physiologic significance in neonates remain to be elucidated.

We report an electron-spin-resonance (ESR) study of stoichiometric La1-x Cax Mn O3 for 0

Square planar neutral dimethyl and cationic allyl complexes of palladium with the electronically nonsymmetric diphenylphosphinomethyl- and pyridyl-N-heterocyclic carbene ligands have been synthesized and characterized. The products from the protonation of the dimethyl complexes with 1 equiv of acid at low temperatures are monomethyl cations, the exact nature of which is dependent on the type of ligand; in pyridine-carbene complexes the Pd-Me bond cleaved is trans to the carbene, while for the phosphino-carbene complexes it is trans to the phosphine. Density functional calculations suggest that protonation in these complexes occurs directly at the methyl ligands and that the site of protonation determines the selectivity of Pd-Me cleavage. For the pyridine-carbene complexes there is a clear preference for protonation trans to the carbene. For phosphino-carbene complexes, however, the site of protonation depends on the steric bulk of the N-heterocyclic carbene ligand. Protonation trans to carbene is favored with small substituents (H, Me), but the bulky 2,6-Pri2C6H3 susbstituent induces protonation trans to the phosphine, as is seen experimentally. © 2007 American Chemical Society.

Phospholamban (PLN) is a key regulator of Ca(2+) homeostasis and contractility in the heart. Its regulatory effects are mediated through its interaction with the sarcoplasmic reticulum Ca(2+)-ATPase, (SERCA2a), resulting in alterations of its Ca(2+)-affinity. To identify additional proteins that may interact with PLN, we used the yeast-two-hybrid system to screen an adult human cardiac cDNA library. HS-1 associated protein X-1 (HAX-1) was identified as a PLN-binding partner. The minimal binding regions were mapped to amino acid residues 203-245 for HAX-1 and residues 16-22 for PLN. The interaction between the two proteins was confirmed using GST-HAX-1, bound to the glutathione-matrix, which specifically adsorbed native PLN from human or mouse cardiac homogenates, while in reciprocal binding studies, recombinant His-HAX-1 bound GST-PLN. Kinetic studies using surface plasmon resonance yielded a K(D) of approximately 1 muM as the binding affinity for the PLN/HAX-1 complex. Phosphorylation of PLN by cAMP-dependent protein kinase reduced binding to HAX-1, while increasing concentrations of Ca(2+) diminished the PLN/HAX-1 interaction in a dose-dependent manner. HAX-1 concentrated to mitochondria, but upon transient co-transfection of HEK 293 cells with PLN, HAX-1 redistributed and co-localized with PLN at the endoplasmic reticulum. Analysis of the anti-apoptotic function of HAX-1 revealed that the presence of PLN enhanced the HAX-1 protective effects from hypoxia/reoxygenation-induced cell death. These findings suggest a possible link between the Ca(2+) handling by the sarcoplasmic reticulum and cell survival mediated by the PLN/HAX-1 interaction.

Two polyamine copper(II) compounds of spermine analogues: Cu[H2N(CH2)3NH (CH2)2NH(CH2)3NH2] (ClO4)2 (abbreviated as Spc323) and Cu[H2N(CH2)3NH (CH2)3NH(CH2)3NH2] (ClO4)2 (abbreviated as Spc333) have been synthesized and characterized by spectroscopic methods. The electron paramagnetic resonance (EPR) and photoacoustic spectroscopies have been used for studying CU2+ d-d transitions. The EPR spectra of copper(II) ions in both complexes have displayed a different crystal field symmetry: orthorhombic for Spc323 complex, and axial, with the hyperfine interaction, for Spc333 complex. In the visible region of electromagnetic radiation the photoacoustic absorptions from the d-d electron transitions with different energies and linewidths have been observed. Comparison of the obtained results is made with previous measurements on similar spermine compounds. © 2007 Advanced Study Center Co. Ltd.

A quantitative analysis of coccolithophores, planktonic foraminifera and pollen assemblages was carried out on core NS-14 (SE Aegean Sea), recovered in the Western Kos Basin. Eleven coccolithophore (ACE1-11) and ten planktonic foraminifera (APFE1-10) ecozones have been recognized during the last 14 000 yrs using calcareous nannofossil and planktonic foraminifera abundances. Additionally eight pollen assemblage zones (PAZ1-8) have been recognised. The established high resolution ecozonal scheme allows a detailed paleoecological reconstruction for the Holocene archive in the SE Aegean Sea, defining two warm and humid phases (9300-8600 yr cal BP and 7600-6400 yr cal BP) associated with the deposition of S1 and a third one between 5200-4200 yr cal BP. 

A quantitative analysis of coccolithophores, planktonic foraminifera and pollen assemblages was carried out on core NS-14 (SE Aegean Sea), recovered in the Western Kos Basin. Eleven coccolithophore (ACE1-11) and ten planktonic foraminifera (APFE1-10) ecozones have been recognized during the last 14 000 yrs using calcareous nannofossil and planktonic foraminifera abundances. Additionally eight pollen assemblage zones (PAZ1-8) have been recognised. The established high resolution ecozonal scheme allows a detailed paleoecological reconstruction for the Holocene archive in the SE Aegean Sea, defining two warm and humid phases (9300-8600 yr cal BP and 7600-6400 yr cal BP) associated with the deposition of S1 and a third one between 5200-4200 yr cal BP. 

The aim of our study is to describe the prevalence of the different HPV types in women with pre-neoplastic lesions of the cervix in Greece. Cervical scrapes from 841 women were obtained for both cytological evaluation and analysis for the presence of HPV DNA. PCR was performed on specimens from these 841 women. The Pap test results were normal or showed benign cellular changes in 45.8% of the women, atypical squamous cells of undetermined significance (ASCUS) in 23.2%, low-grade squamous intra-epithelial lesion (LSIL) in 27.9% and high-grade squamous intra-epithelial lesion (HSIL) in 3.1%. HPV DNA was demonstrated in 23.6% of cytologically normal women. We detected HPV in 60% of the total samples. Of these, HPV-16 was the most common HPV DNA detected. Interestingly, HPV-58 was inversely correlated with positive cytological findings. A clear pattern of decreasing prevalence of HPV with age was also observed. Our results indicate that HPV infections, especially those with HPV-16, represent a significant public health concern in Greece

We report the discovery of a possible nova in M31 on four consecutive dithered R filter CCD images obtained on (2007 July 05.04813, 05.04966, 05.05122, 05.05278, with corresponding R magnitudes of 16.7, 16.6, 16.6, 16.6) obtained at the 1.3m Ritchey Chretien f/7.5 telescope at Skinakas Observatory, Crete, Greece, using the Roper CCD Camera (with a SITE 1k x 1k chip with 24µm sq. pixels). The position obtained for the nova candidate is RA(2000) = 00h 43m 04.05s, Dec(2000) = +41° 17' 08.3" with an accuracy of 0.1".

Sárvíz Valley is approximately 100km long, situated SW from capital of Hungary (Budapest). The total examined area of the valley is 60561.85ha. The soil cover is very mosaic, but the larger spots belong to Chernozems. We prepared the soil map of the valley, based on former soil maps, core samplings and aerial photographs. Based on the soil map we prepared the erosion map on the territory of the Sárvíz Valley Small Region Association. Erosion modeling was done by the USLE (Universal Soil Loss Equation) model. We marked areas where different amount of special attention and soil protection measures are needed. One of the basic aims of this study is the application of soil mapping and modeling for the calculation of erosion. With the help of these tools we are able to outline the areas which, as far as erosion is concerned, are in need of protection, as well as the less useful areas for agricultural production.