Publications by Year: 2008

Parotid acinic cell carcinoma is a rare malignancy in childhood. We report the case of a 12-year-old girl presenting with a palpable mass in the left maxillofacial area. The radiologic evaluation showed a parotid mass. Tumour resection revealed acinic cell carcinoma of the parotid gland. She underwent complementary total parotidectomy without any adjuvant treatment. The patient has been disease-free for the last five years. We review the literature on acinic cell carcinomas of parotid glands in childhood.

AIM: Obesity has been implicated in the aetiology of myelogenous leukaemia and myelodysplasia (MDS). We hypothesised that altered secretion of adiponectin and resistin may underlie this association. We thus investigated the role of both total and high molecular weight (HMW) adiponectin and resistin in MDS. METHODS: In a case-control study, we studied 101 cases with incident, histologically confirmed primary MDS and 101 controls matched on gender and age between 2004 and 2007. Total and HMW adiponectin, resistin, insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein (IGFBP-3) were determined. RESULTS: Lower serum total or HMW adiponectin and/or resistin levels were independently associated with higher risk of MDS controlling for age, gender, BMI and serum levels of leptin, IGF-I and IGFBP-3 (p<0.002). Although total and HMW adiponectin were both significantly inversely associated with MDS when modelled either in quartiles or continuously, HMW did not offer any substantial additional predictive value over total adiponectin (Odds ratio (OR)=0.91 versus 0.93 for a 1 microg/ml change, respectively). IGF-I was positively associated with MDS by bivariate analysis and both IGF-I and IGFBP-3 were higher in advanced MDS and higher risk stages, but were not significantly and independently associated with MDS. CONCLUSION: Total and HMW adiponectin may have a protective role in MDS, whereas resistin levels may be decreased via a compensatory mechanism.

Adolescent gynaecology is increasingly recognized as an area in which specific knowledge and expertise is required to ensure the best outcome. Gynaecological problems in adolescents are common and, although serious disease is rare, distress and discomfort can be significant. Adolescent girls are under great pressure, particularly in terms of examination performance, and problems such as menstrual dysfunction can be particularly difficult to manage. Careful and sympathetic assessment is crucial, and simple treatment remedies may be sufficient. Complex and rare medical conditions can also occur and must not be missed. Some congenital disorders present for the first time in adolescence. Early detection and appropriate treatment ensures the best possible outcome in terms of sexual function and potential fertility. © 2008 Elsevier Ltd. All rights reserved.

The remarks presented in this article focus on the importance of Afghan-Pakistani Islam with the Salafist, Takfirist and internationalist holy war tendencies and linkages within the context of the Iraq-Lebanon axis. The subversive potential of the Islamist movement, combined with the export of Shiite Islamist extremism through Tehran, emerge as significant factors of instability in the region. Also, the tolerance exhibited by Washington, with regard to the formation and activity of extremist Salafist movements, to counterbalance Iran’s export of Islamist subversive practices to the countries of the region (Lebanon, Iraq, Hamas-Gaza), is considered dangerous and requiring revision. Finally, a general strategy plan is proposed for establishing peace in the region, by removing the ideological footholds of the cores of the nationalist and internationalist Islamist movement.

In this study, the variability and trends of the mean annual and seasonal surface air temperature in Greek peninsula are examined. The climatic data used, concern mean monthly values of air temperature of 20 meteorological stations of the Hellenic Meteorological Service, for the period 1951-2000. The air temperature time series for each station are analyzed, so that the variability and trends be described. Regarding the annual time series, a cooling trend is observed since the early 1960's till the middle of the decade of 1970, when the trend reverses to heating till nowadays. It is remarkable that the today air temperature levels do not exceed the levels of the middle of the century. During the winter, it is crystal clear that a cooling trend exists from the middle of the decade of 1950 to the end of the decade of 1980, especially in the south region of the country. Afterwards an increasing trend is obvious till nowadays. The pattern in spring appears a slight heating trend in the northern region of Greece and a cooling trend in the south. The summer time series are similar to the annual ones, so the contribution of summer to annual variability is unquestionable. Generally speaking, the air temperature in autumn follows the same distribution in time. In the process, the Factor Analysis is applied on the mean annual and seasonal air temperature and thereafter the regions, within the air temperature covariates, are defined. Finally, the application of spectral analysis to annual and seasonal air temperature is regarded necessary so that the periodicities are derived. © 2008 Global NEST Printed in Greece. All rights reserved.

CCD photometric observations of the Algol-type eclipsing binary TZ Eri have been obtained in B and V filters during 26 nights from December 2007 to February 2008 at the Athens University Observatory. The light curves are analyzed with the Wilson-Devinney code, new geometric and photometric elements are derived, a time series analysis of the observations is applied and a multiperiodic behavior is also discussed. The presence of a third light in the system is considered and our results are compared with those of the O-C analysis for a third body in the system, given by Zasche et al. (2008).

BACKGROUND/AIMS: Alpha-1 antichymotrypsin (ACT), a serine proteinase inhibitor, has been implicated in vascular pathology. The TT genotype of the ACT signal peptide A/T polymorphism has been reported to confer susceptibility to primary intracerebral hemorrhage (PICH). We conducted a prospective study to test possible association of ACT signal peptide A/T polymorphism with PICH in a Greek cohort with enough power (80%) to detect a twofold increase in the odds ratio. METHODS: We prospectively recruited 147 patients with PICH. ACT signal peptide A/T genotypes were determined in patients and 206 healthy, age- and sex-matched control subjects from the neurology outpatient clinic using the polymerase chain reaction restriction fragment length polymorphism method. RESULTS: Our study did not show an association between ACT signal peptide A/T polymorphism and PICH. We also failed to find any influence on age at onset, the location and volume of PICH as well as on clinical severity at admission or 6-month outcome. CONCLUSION: Our data failed to confirm an association between ACT signal peptide A/T polymorphism and PICH. However, we cannot exclude the possibility that the TT genotype confers susceptibility at less than a twofold increase.

Various scenarios of contact binary evolution have been proposed in the past, giving hints of (sometimes contradictory) evolutionary sequences connecting A- and W-type systems. As the components of close detached binaries approach each other and contact binaries are formed, following evolutionary paths transforms them into systems of two categories: A-type and W-type. The systems evolve in a similar way but under slightly different circumstances. The mass/energy transfer rate is different, leading to quite different evolutionary results. An alternative scenario of evolution in contact is presented and discussed, based on the observational data of over one hundred low-temperature contact binaries. It results from the observed correlations among contact binary physical and orbital parameters. Theoretical tracks are computed assuming angular momentum loss from a system via stellar wind, accompanied by mass transfer from an advanced evolutionary secondary to the main-sequence primary. A good agreement is seen between the tracks and the observed graphs. Independently of details of the evolution in contact and a relation between A- and W-type systems, the ultimate fate of contact binaries involves the coalescence of both components into a single fast rotating star.

This study examined selected anthropometric characteristics of young rowers and compared them with those of senior national level athletes and untrained children, in order to establish a rowing specific anthropometric profile for young athletes. Anthropometric characteristics were measured in 509 club-level rowers aged 11-16 years and 29 male senior national level rowers. Club-level athletes were categorized in 6 age groups (11-16 y), while the senior national level rowers were divided into heavyweight (H-W) and lightweight (L-W). Rowers aged 15 and 16 y had similar height, body weight, arm length and leg length, but lower lean body mass (5 to 8.3 Kg less) compared with senior L-W rowers. Comparison of the young rowers with a reference group of untrained Greek children by means of percentiles (P) revealed that rowers in all age groups were heavier (P63 to P75), taller (P82 to P90) but had a lower body mass index than the mean values (P50) of the reference group after the age of 14 (P48 to P43). Skinfold thicknesses and body fat decreased from the 11 y through to the 16 y group (from 22.9% to 17.8%), and were lower in the two senior groups (9.6% for the L-W and 12.3% for the H-W). Endomorphy ratings decreased with age from 11 to 14 y, but there was no difference between the 14 to 16 y old groups. Mesomorphy was similar across all groups examined and ectomorphy did not show large fluctuations from the 13 y old group onwards. Somatotype of the 15 y old group was 2.4-4.4-3.4 (endo-mesoectomorphy) and was identical to that of the 16 y group and the lightweight senior rowers. The results of this study showed that the club level rowers aged 15 and 16 yrs have similar body structure but different body composition compared with the senior L-W rowers. Anthropometric characteristics can be used as a criterion for selection of rowers by the coaches from an early age.

This study examined selected anthropometric characteristics of young rowers and compared them with those of senior national level athletes and untrained children, in order to establish a rowing specific anthropometric profile for young athletes. Anthropometric characteristics were measured in 509 club-level rowers aged 11-16 years and 29 male senior national level rowers. Club-level athletes were categorized in 6 age groups (11-16 y), while the senior national level rowers were divided into heavyweight (H-W) and lightweight (L-W). Rowers aged 15 and 16 y had similar height, body weight, arm length and leg length, but lower lean body mass (5 to 8.3 Kg less) compared with senior L-W rowers. Comparison of the young rowers with a reference group of untrained Greek children by means of percentiles (P) revealed that rowers in all age groups were heavier (P63 to P75), taller (P82 to P90) but had a lower body mass index than the mean values (P50) of the reference group after the age of 14 (P48 to P43). Skinfold thicknesses and body fat decreased from the 11 y through to the 16 y group (from 22.9% to 17.8%), and were lower in the two senior groups (9.6% for the L-W and 12.3% for the H-W). Endomorphy ratings decreased with age from 11 to 14 y, but there was no difference between the 14 to 16 y old groups. Mesomorphy was similar across all groups examined and ectomorphy did not show large fluctuations from the 13 y old group onwards. Somatotype of the 15 y old group was 2.4-4.4-3.4 (endo-mesoectomorphy) and was identical to that of the 16 y group and the lightweight senior rowers. The results of this study showed that the club level rowers aged 15 and 16 yrs have similar body structure but different body composition compared with the senior L-W rowers. Anthropometric characteristics can be used as a criterion for selection of rowers by the coaches from an early age.

This study examined selected anthropometric characteristics of young rowers and compared them with those of senior national level athletes and untrained children, in order to establish a rowing specific anthropometric profile for young athletes. Anthropometric characteristics were measured in 509 club-level rowers aged 11-16 years and 29 male senior national level rowers. Club-level athletes were categorized in 6 age groups (11-16 y), while the senior national level rowers were divided into heavyweight (H-W) and lightweight (L-W). Rowers aged 15 and 16 y had similar height, body weight, arm length and leg length, but lower lean body mass (5 to 8.3 Kg less) compared with senior L-W rowers. Comparison of the young rowers with a reference group of untrained Greek children by means of percentiles (P) revealed that rowers in all age groups were heavier (P63 to P75), taller (P82 to P90) but had a lower body mass index than the mean values (P50) of the reference group after the age of 14 (P48 to P43). Skinfold thicknesses and body fat decreased from the 11 y through to the 16 y group (from 22.9% to 17.8%), and were lower in the two senior groups (9.6% for the L-W and 12.3% for the H-W). Endomorphy ratings decreased with age from 11 to 14 y, but there was no difference between the 14 to 16 y old groups. Mesomorphy was similar across all groups examined and ectomorphy did not show large fluctuations from the 13 y old group onwards. Somatotype of the 15 y old group was 2.4-4.4-3.4 (endo-mesoectomorphy) and was identical to that of the 16 y group and the lightweight senior rowers. The results of this study showed that the club level rowers aged 15 and 16 yrs have similar body structure but different body composition compared with the senior L-W rowers. Anthropometric characteristics can be used as a criterion for selection of rowers by the coaches from an early age.

Patent WO02095012A1 claims for the development of antibodies against receptor activator of nuclear factor-κ B ligand (RANKL) and immunologically functional fragments that neutralize RANKL. These molecules can be used to detect RANKL in biological samples, allowing the identification of pathological conditions in which RANKL alteration contributes to their pathophysiology. The use of anti-RANKL antibodies is of high importance in the treatment of bone disorders characterized by the stimulation of osteoclast function and subsequent bone loss. Postmenopausal and steroid-induced osteoporosis, myeloma bone disease, cancer bone metastases with lytic lesions and bone loss due to rheumatoid disorders (including rheumatoid arthritis) are candidates for anti-RANKL therapy, as RANKL is implicated in their pathogenesis. © 2008 Informa UK Ltd.

OBJECTIVE: To determine whether APOE epsilon 4 predicts rate of cognitive change in incident and prevalent Alzheimer disease (AD). METHODS: Individuals were recruited from two longitudinal cohort studies-the Washington Heights and Inwood Columbia Aging Project (WHICAP; population-based) and the Predictors Study (clinic-based)--and were followed for an average of 4 years. Three samples of participants diagnosed with AD, with diverse demographic characteristics and baseline cognitive functioning, were studied: 1) 199 (48%) of the incident WHICAP cases; 2) 215 (54%) of the prevalent WHICAP cases; and 3) 156 (71%) of the individuals diagnosed with AD in the Predictors Study. Generalized estimating equations were used to test whether rate of cognitive change, measured using a composite cognitive score in WHICAP and the Mini-Mental State Examination in Predictors, varied as a function of epsilon 4 status in each sample. RESULTS: The presence of at least one epsilon 4 allele was associated with faster cognitive decline in the incident population-based AD group (p = 0.01). Parallel results were produced for the two prevalent dementia samples only when adjusting for disease severity or excluding the most impaired participants from the analyses. CONCLUSION: APOE epsilon 4 may influence rate of cognitive decline most significantly in the earliest stages of Alzheimer disease.

Controlling healthcare costs is a multifaceted problem for governments all over the world, as they have the difficult task of ensuring that patients receive high quality care, and that this is delivered as efficiently as possible. Through the use of quantitative analysis, an attempt is made to determine the areas of activity of 32 Greek Public Obstetrical and Gynaecological Units which present problems with regard to their performance. Based on the results that emerge from the application of Data Envelopment Analysis in the 32 hospital units of the sample, information is provided to their managers, which refer to: (i) the degree of utilization of their production factors, (ii) the particular weight of each factor of production in the formation of the relative efficiency score, (iii) the utilization level of each factor of production, and (iv) those hospital units that utilize their factors of production in an optimal way and constitute models for the exercising of effective management. The derived information assists in the formulation of an appropriate policy mix per hospital unit which should be applied by their management teams along with a set of administrative measures that need to be undertaken in order to promote efficiency. © 2007 Elsevier Ireland Ltd. All rights reserved.

Background in musicThis paper compounds an approach of music creation in ancient Greek tragedy in Greece, during the XXthcentury, focusing in the avant- guard composition techniques and especially in mixing instrumental, vocal ande/a (electroacoustic) means with a critical view on the works of Xenakis, Christou, Adamis and Vasiliadisconcerning the reforming of the micro-macro-musical structure.Background in compositionThis paper refers also, to a particular point of view in composition using e/a material in order to achieve thissound structure that conventional means could not create. This is an advantage of the e/a sound editing,based on the flexibility of handling the sound as a plastic material. This technical topic brings new aestheticand structural questions so at the conception of a work as at its realization too. A critical confrontation ofediting ready given samples to newly made.AimsDistinguishing the recorded playback music from the e/a material we realize the second one gives theopportunity to keep an eye open closer to the “ethos” of the text. Independently of specified styles andtechniques, the challenge transforming symbolism in abstract sound is risky and if stylized becomes guide tosuperficial performance so often in the (recent) past.Aiming to approve this interaction between music structure - aesthetic approach and text - sound, formcomes to be a servant of nowadays needs in realizing an ancient tragedy.ContributionAs the technological contribution in sound editing and composition leads to new fields of aesthetic andstructural quest it was expected to influence the music for theatre. Through these new tendencies thelimitation in serving the text is also the freedom to give the abstract and symbolic light of it. As directorswade into ancient tragic theme through contemporary hypocritical techniques and directing views, composersare capable to rely upon new technology.ImplicationsMoving away form the classical techniques for composing music for the ancient Greek tragedy based on theancient and Byzantin melos as it was seen the first half of the XXth century by many Greek composers andbringing the avant-garde techniques in combination to the new e/a media as a ritualistic reinforcement of thetext , this paper intends to focus on the new structures, means and compositional techniques through acomposer’s view . The above points that this novel study in e/a techniques may have many implications bothin musicological as in music theory domain. Firstly, because it scopes to redefine the compositional strategiesthrough the digital medium according the needs of the text and secondly because it introduces new aestheticapproaches that reinforce the “tragic| element through the e/a media.Aspects of musical structure and functionality of electroacoustic media in the performance of ancient Greek tragedy. A composers’ point of view Normal 0 false false false EN-US JA X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Times New Roman",serif; text-shadow:auto; mso-fareast-language:JA;}

We cloned and characterized an Aspergillus nidulans gene, called fcyB, encoding the closest homologue to the yeast Fcy2p/Fcy21p permeases. Deletion of fcyB (DeltafcyB) does not affect growth, development, reproduction or bulk purine uptake, but eliminates the leaky growth on purines of DeltaazgADeltauapCDeltauapA strains, lacking all known purine transporters, and confers resistance to the antifungal 5-fluorocytosine. Kinetic analyses showed FcyB is a low-capacity, high-affinity, cytosine-purine transporter sharing similar molecular interactions for substrate recognition with the yeast Fcy2p/Fcy21p carriers. fcyB transcription is highly activated during germination but drops at low constitutive levels throughout vegetative development. UaY-mediated purine induction of fcyB transcription is only moderate, while ammonium represses transcription through an AreA-dependent mechanism. A strain expressing FcyB-GFP confirms a low protein expression level in the plasma membrane of vegetative mycelia, but reveals an abundant expression in sexual and asexual compartments. FcyB-GFP was also shown to be downregulated by endocytosis in response to ammonia or the presence of cytosine. The expression profile of FcyB supports that its main physiological role is cytosine-purine scavenging.

Thyroid disease has been associated with lymphohematopoietic cancer (LHC). No previous study using clinical, sonographic and laboratory data has explored whether thyroid disease and specifically autoimmune thyroid disease (ATD) is associated with multiple myeloma (MM) risk. 73 patients with incident primary MM and 73 hospital controls admitted for non-neoplastic and non-infectious conditions, matched on gender and age were studied between 2001 and 2007. Blood samples were collected. All subjects were submitted to clinical, ultrasound and laboratory thyroid evaluation. The prevalence of clinical thyroid disease in MM patients was significantly higher than in controls (p = 0.002). ATD was associated with increased risk of MM, adjusting for age, gender, body mass index and familial history of LHC [OR = 5.68, 95% confidence interval (CI): 1.69-19.13]. Controlling for the above variables, an individual suffering from any thyroid disease more than 10 years has about 2.41 times more likely the risk to develop MM than an individual without any thyroid disease (OR = 2.41, 95% CI: 1.35-4.29). Also, adjusting for age, gender, BMI and family history of LHC, a familial history of thyroid disease is associated with increased risk of MM (OR = 3.23, 95% CI: 1.25-8.31). Further studies are needed to explore underlying mechanisms associating thyroid autoimmunity with plasma cell transformation.

BACKGROUND: 5382insC BRCA1 frameshift mutation is a common founder mutation for many populations worldwide and a high-risk allele for the development of hereditary breast and/or ovarian cancer. Our goal was to develop a novel, reliable and rapid method for its detection. METHODS: We developed an asymmetric real-time PCR method with hybridization probes in the LightCycler. Genotyping was performed by melting curve analysis. RESULTS AND CONCLUSIONS: The developed method was in concordance with reference methods when tested in 85 peripheral blood and 107 tumor DNA samples from Greek breast and/or ovarian cancer patients. The described method proved to be simple, cost-effective, easy to perform and rapid enough for routine use as a screening method in high-risk families and especially in the Greek, Slavic and Jewish populations where 5382insC mutation is the most common BRCA1 mutation

We calculate the ground and excited electron and hole levels in spherical Si nanocrystals (quantum dots) embedded within SiO 2 in a multiband effective mass approximation. The obtained energies of electron and hole are used to estimate the Auger Recombination (AR) lifetime in Si Nanocrystals (NCs). The excited electron, excited hole and biexciton AR types are considered. © 2008 WILEY-VCH Verlag GmbH & Co. KGaA.

Aurora kinases represent a family of serine/threonine kinases highly conserved during evolution, whose main function is to promote mitotic spindle assembly by regulating centrosome duplication and separation. Inhibition of Aurora kinase activity may lead to defects in centrosome function, misaligned sister chromatides, mitotic spindle malformation, problematic cytokinesis and eventually mitotic arrest. Aurora kinases are overexpressed in a variety of tumor cell lines, suggesting their potential role in tumorigenesis and indicating that they could represent an appealing target for molecular therapies. Extensive pre-clinical information supports the development of Aurora kinase inhibitors in specific tumor types and a number of these novel agents are currently being extensively studied in phase I and II clinical trials exhibiting an acceptable toxicity profile and promising clinical efficacy. The current study aims to provide a comprehensive overview of the development of Aurora kinases as molecular targets for anticancer therapy by focusing on their physiological role in mitosis, their implication in oncogenesis and the potential ways of inhibiting their activity. The main pre-clinical and clinical studies concerning Aurora kinase inhibitors currently under investigation are reported and important considerations for their future development are discussed. © 2007 Elsevier Ltd. All rights reserved.

Magnetically assisted hemodialysis is a development of conventional hemodialysis and is based on the circulation of ferromagnetic nanoparticle-targeted binding substance conjugates (FN-TBS Cs) in the bloodstream of the patient and their eventual removal by means of a 'magnetic dialyzer'. Presented here is an in vitro investigation on the biocompatibility of bare Fe3O4 FNs and Fe3O4-bovine serum albumin Cs with blood cells, namely red blood cells (RBCs), white blood cells (WBCs) and platelets (Plts). Atomic force microscopy (AFM) and optical microscopy (OM) enabled the examination of blood cells at the nanometer and micrometer level, respectively. The observations made on FN- and C-maturated blood samples are contrasted to those obtained on FN- and C-free reference blood samples subjected to exactly the same maturation procedure. Qualitatively, both AFM and OM revealed no changes in the overall shape of RBCs, WBCs and Plts. Incidents where bare FNs or Cs were bound onto the surface of RBCs or internalized by WBCs were very rare. Detailed examination by means of OM proved that impaired coagulation of Plts is not initiated/promoted either by FNs or Cs. Quantitatively, the statistical analysis of the obtained AFM images from RBC surfaces clearly revealed that the mean surface roughness of RBCs maturated with bare FNs or Cs was identical to the one of reference RBCs.

This is a summary report of the EUFEPS & COST B25 conference on Bioavailability and Bioequivalence which focused on physiological factors and variability. This conference was held at The Royal Olympic Hotel in the centre of Athens (Greece) during the 1-2 of October in 2007. The issues discussed in the conference involved physiological factors affecting drug absorption, the role of pre-systemic effects on bioavailability (BA), the impact of variability in bioequivalence (BE) studies, and a final closing panel session on unresolved issues in BA/BE regulations. Several important aspects of drug absorption were highlighted. It was presented how the complexity of gastrointestinal (GI) physiology and the site dependent absorption can impact on drug BA. Similarly, the effects of food and formulation were also studied. The second session focused on integrating the complexities of GI into modeling the inter-individual variability of absorption and the prediction of first-pass metabolism from in-vitro data. The necessity to measure metabolites, the value of Biopharmaceutical Classification System (BCS), and the more recently proposed Biopharmaceutical Drug Disposition Classification System (BDDCS) were assessed as well. This session closed with presentations of pharmacokinetic software delegates. In the second day of the conference, the problem of high intra-subject variability in BE studies was analyzed. Study design considerations, the use of multiple-dose studies and the role of statistics in BE were also highlighted. Finally, the current thinking of regulatory authorities (EMEA and US-FDA) was presented. The conference closed with a last session on unresolved issues in the regulatory level.

Objectives: Docetaxel is an effective first-line treatment for hormone-refractory prostate cancer. Nevertheless, the prognosis subsequent to progression after first-line therapy is poor and no second-line treatment has been established. Methods: A total of 34 patients with androgen-independent prostate cancer received doxorubicin, 30 mg/m2, every 2 weeks and ketoconazole daily, 400 mg orally every 8 hours. All patients had been treated with docetaxel and had disease progression within 6 months after completion of first-line treatment. Results: Of the 32 evaluable patients, 13 (43.7%, 95% confidence interval [CI] 26.3% to 62.3%) had a prostate-specific antigen (PSA) response, and 4 (28%, 95% CI 8.4% to 58.1%) of 14 patients with measurable disease had a response to therapy. The median time to progression (TTP) was 3.9 months (95% CI 2.0 to 5.9), and the median overall survival (OS) was 13 months (95% CI 8.7 to 17.3). Toxicity was mild, with only 4 cases of nonhematologic grade 3 or 4 toxicity. The most frequent toxicity was nail changes (33 of 34 patients), which was mainly grade 1 (30 cases). Conclusions: The combination of biweekly doxorubicin and ketoconazole is an effective, well-tolerated, second-line therapy for hormone-refractory prostate cancer. © 2008 Elsevier Inc. All rights reserved.

Background: Bortezomib is a novel, first-in-class proteasome inhibitor that has improved outcomes in multiple myeloma. with manageable toxicities. Objective: To summarise the chemistry, pharmacokinetics and metabolism of bortezomib, and review its clinical efficacy and toxicity, including use in elderly patients, use in patients with renal impairment and/or a poor prognosis, and effects on bone metabolism. Methods: Literature search of bortezomib studies (within 10 years) and recent congress abstracts. Results/conclusions: Bortezomib has improved response rates, overall survival, and time to progression in relapsed or refractory disease, both as a single agent and as part of combination regimens. Promising results have also been reported with bortezomib combinations in frontline induction therapy. Patient subgroups where conventional approaches are inappropriate may also benefit, thereby expanding the therapeutic armamentarium against this debilitating disease. © 2008 Informa UK Ltd.

Background: The standard treatment for patients with multiple myeloma who are not candidates for high-dose therapy is melphalan and prednisone. This phase 3 study compared the use of melphalan and prednisone with or without bortezomib in previously untreated patients with multiple myeloma who were ineligible for high-dose therapy. Methods: We randomly assigned 682 patients to receive nine 6-week cycles of melphalan (at a dose of 9 mg per square meter of body-surface area) and prednisone (at a dose of 60 mg per square meter) on days 1 to 4, either alone or with bortezomib (at a dose of 1.3 mg per square meter) on days 1, 4, 8, 11, 22, 25, 29, and 32 during cycles 1 to 4 and on days 1, 8, 22, and 29 during cycles 5 to 9. The primary end point was the time to disease progression. Results: The time to progression among patients receiving bortezomib plus melphalan-prednisone (bortezomib group) was 24.0 months, as compared with 16.6 months among those receiving melphalan-prednisone alone (control group) (hazard ratio for the bortezomib group, 0.48; P<0.001). The proportions of patients with a partial response or better were 71% in the bortezomib group and 35% in the control group; complete-response rates were 30% and 4%, respectively (P<0.001). The median duration of the response was 19.9 months in the bortezomib group and 13.1 months in the control group. The hazard ratio for overall survival was 0.61 for the bortezomib group (P=0.008). Adverse events were consistent with established profiles of toxic events associated with bortezomib and melphalan-prednisone. Grade 3 events occurred in a higher proportion of patients in the bortezomib group than in the control group (53% vs. 44%, P=0.02), but there were no significant differences in grade 4 events (28% and 27%, respectively) or treatment-related deaths (1% and 2%). Conclusions: Bortezomib plus melphalan-prednisone was superior to melphalan-prednisone alone in patients with newly diagnosed myeloma who were ineligible for high-dose therapy. (ClinicalTrials.gov number, NCT00111319.). Copyright © 2008 Massachusetts Medical Society. All rights reserved.

We present an efficient computational methodology for full electrodynamic calculations of metallodielectric nanostructures based on a multiple-scattering formulation of Maxwell's equations. The method, originally developed for systems of spherical particles (MULTEM code), is extended to systems of particles of arbitrary shape and applied to ordered structures of metallic nanodisks with an aspect ratio as large as five. We first discuss the particle plasmon resonances of single metallic nanocylinders of different aspect ratios. Then, we study the plasmonic excitations of square arrays of metal-dielectric-metal nanosandwiches and the optical response of a rectangular lattice of metallic nanodisks on a dielectric waveguide. Finally we analyse the photonic band structure of a simple cubic crystal of metallic nanodisks.

Introduction: The combination of Carboplatin and Paclitaxel is considered the standard of care as initial chemotherapy for Advanced Ovarian Cancer (AOC). We compared this regimen with the combination of Cisplatin, Paclitaxel and Doxorubicin. Patients and methods: Patients with AOC were randomised to either six courses of Paclitaxel 175 mg/m2 plus Carboplatin 7AUC or Paclitaxel at the same dose plus Cisplatin 75 mg/m2 plus Doxorubicin 40 mg/m2. Results: Analysis was performed on 451 patients. The treatment groups were well balanced with regard to patient and disease characteristics. Performance status (PS) was better in the anthracycline arm. In terms of severe toxicity, the only significant difference between the two groups was the development of febrile neutropaenia in the anthracycline arm. Overall response rate was similar in both groups. With a median follow-up of 57.5 months, a marginal significance towards improved Progression-Free Survival (PFS) was noted in favour of the anthracycline arm, whilst there was no difference in overall survival. In multivariate analysis the hazard of disease progression at any time was significantly decreased by 25.5% for patients of the anthracycline arm. Conclusion: The combination of Cisplatin, Paclitaxel and Doxorubicin demonstrates a marginal PFS improvement, but no additional survival benefit when compared with the standard Carboplatin/Paclitaxel regimen. © 2008 Elsevier Ltd. All rights reserved.

There is evidence that selenium levels are relatively low in Europe and may be falling. Low levels of selenium or low activity of some of the enzymes dependent on selenium have been associated with asthma.|The GA(2)LEN network has organized a multicentre case-control study in Europe to assess the relation of plasma selenium to asthma. The network compared 569 cases in 14 European centres with a diagnosis of asthma and reporting asthma symptoms in the last 12 months with 576 controls from the same centres with no diagnosis of asthma and no asthmatic symptoms in the last 12 months.|All cases and controls were selected from the same population defined by age and place of residence. Mean plasma selenium concentrations among the controls ranged from 116.3 microg/l in Palermo to 67.7 microg/l in Vienna and 56.1 microg/l among the children in Oslo. Random effects meta-analysis of the results from the centres showed no overall association between asthma and plasma selenium [odds ratio (OR)/10 microg/l increase in plasma selenium: 1.04; 95% confidence interval (CI): 0.89-1.21] though there was a significantly protective effect in Lodz (OR: 0.48; 95% CI: 0.29-0.78) and a marginally significant adverse effect in Amsterdam (OR: 1.68; 95% CI: 0.98-2.90) and Ghent (OR: 1.35; 95% CI: 1.03-1.77).|This study does not support a role for selenium in protection against asthma, but effect modification and confounding cannot be ruled out.

Greek has always been assumed to possess a verbal system organized on the basis of aspect, with tense playing only a secondary part, and to have retained this state of affairs throughout its history. This article claims that it has changed substantially, moving from the expression of oppositions of Aktionsart (states – telic activities – atelic activities) to the expression of oppositions of grammatical aspect (perfective – imperfective) and tense (past – non past and later past – present – future). The current system is claimed to display an almost perfect balance between tense and aspect. Keywords: tense; aspect; verbal system; Aktionsart; perfectivity

The aim of this study was to examine if Hymel, Tarulli, Hayden Thomson, and Terrell-Deutsch's (1999) three-dimension model of children's loneliness perceptions could be applied in Greece, and to examine age and gender differences in these perceptions. In addition, a more detailed examination of the emotional dimension in the perceptions of loneliness was attempted, based on Parkhurst and Hopmeyer's (1999) hypotheses for the emotions associated with loneliness. One-hundred and eighty 2nd-, 4th-, and 6th-grade children from Athens were interviewed about their understanding and experience of loneliness. Responses fit Hymel et al.'s (1999) model for the perceptions of loneliness, with some additions. Children perceived loneliness as a painful experience with emotional, cognitive, and contextual dimensions. Statistically significant age and gender differences were found in these dimensions, as well as in the loneliness-related emotions. The implications of these findings for the existing theoretical views on loneliness are discussed and suggestions for future research are made.

Adiponectin has potent insulin-sensitizing effects, improves lipid metabolism, and potentially protects against the development of metabolic syndrome. Thus, increasing adiponectin levels in preterm infants at risk for developing metabolic syndrome may be of special interest. The aim of this study was to examine the effects of dietary long-chain polyunsaturated fatty acids (LCPUFA) on serum adiponectin and lipid concentrations in preterm infants. Adiponectin and lipid levels of 60 healthy preterm infants [gestational age 32.7 (1.9) wk] randomly assigned to be fed either 1) a formula containing LCPUFA [arachidonic and docosahexanoic] (+LCPUFA group) or 2) the same formula without LCPUFA (-LCPUFA/control group), were determined at mean (SD) 33.8 (11.7) d. Adiponectin and HDL-C concentrations were significantly higher in the +LCPUFA group than in controls (p = 0.002 and p = 0.01, respectively); whereas, triglyceride levels were lower (p = 0.06). Adiponectin correlated positively with HDL-C levels and negatively with triglyceride levels in the +LCPUFA group but not in the controls. In conclusion, circulating adiponectin concentrations were higher in preterm infants fed a formula containing LCPUFA than infants fed an LCPUFA-free formula and they correlated with lipidemic profile.

Τhe main scope of this book is to illustrate a magnificent marine micro world in eastern Mediterranean Sea waters, the world of Coccolithophores. The eastern Mediterranean Coccolithophores presented in this book have been collected during several cruises and samplings in the Ionian and Aegean Sea at different seasons, between the years 1997-2006. The collected material has been analyzed and photographed by Scanning Electron Microscope and Light Microscope techniques. Αs a result 375 SEM and LM microphotographs are presented together with thorough systematic taxonomy and detailed description of 132 Coccolithophore species. A novelty of this book, compared to traditional atlases, is the trilingual approach of Coccolithophore taxonomy. Each species is described in three languages, English, Greek and Italian. In this way these astonishing beautiful marine microorganisms are getting introduced to a broad public and it becomes easier for non-native English speakers - students and researchers - to get acquainted with the scientific terminology. Additionally the combination of both scanning and light microscope techniques provides the most comprehensive documentation of Coccolithophore species morphology.

Collective plasmonic modes in two- and three-dimensional periodic assemblies of metallic nanoshells are studied by means of full electrodynamic calculations using the layer-multiple-scattering method. We consider structures made of a single type of nanoshell as well as binary heterostructures made of two different types of nanoshells. The complex photonic band structure of such three-dimensional photonic crystals is analyzed in conjunction with relevant transmission diagrams of corresponding finite slabs and the physical origin of the different optical modes is elucidated. Moreover, we discuss associated absorption spectra and provide a consistent interpretation of the underlying physics. In the case of the binary systems, the plasmonic modes of the two building components coexist, leading to a rich structure of resonances over an extended frequency range and to broadband absorption.

Ultra-thin nanocrystalline silicon films with varying thickness from 5 to 30nm were grown on quartz by low pressure chemical vapor deposition (LPCVD) of Si. Observations on cross-sectional transmission electron microscopy (TEM) specimens revealed that the films had a columnar growth, i.e. the third dimension of the nanocrystals, perpendicular to the Si/SiO 2 interface, was approximately equal to the film thickness, while the lateral size of nanocrystals was defined during the initial stage of growth and was not very much affected bythe film thickness. The observed columnar growth gives the possibility to obtain two-dimensional nanocrystal arrays on quartz with well defined size in the z-direction. Plane view images showed that the lateral distribution of nanocrystal size presents a well-defined maximum in all the films. The mean lateral size of the nanocrystals did not change very much with the film thickness, being in the range of 11-13 nm. The number of grains with size larger than the mean one tended to increase with the thickness of the film. © 2008 WILEY-VCH Verlag GmbH & Co. KGaA.

This phase 2 study aimed to determine the efficacy and safety of the combination of bortezomib, melphalan, dexamethasone and intermittent thalidomide (VMDT) and its effect on bone remodeling and angiogenesis in relapsed/refractory myeloma. Bortezomib (1.0 mg/m2) was given on days 1, 4, 8, 11, oral melphalan (0.15 mg/kg) on days 1-4, whereas thalidomide (100mg per day) and dexamethasone (12 mg/m2) were administered on days 1-4 and 17-20 of a 28-day cycle, for four cycles. Patients without disease progression continued for up to eight cycles. VMDT effect on bone remodeling was evaluated by measuring osteoclast regulators (soluble receptor activator of nuclear factor-κ B ligand/osteoprotegerin ratio, osteopontin, macrophage inflammatory protein-1α), dickkopf-1 protein, bone resorption and formation markers, whereas its effect on angiogenesis was assessed by measuring serum vascular endothelial growth factor, angiogenin, angiopoietin-2 and basic fibroblast growth factor, after four cycles and at the study end. A total of 62 patients were enrolled. The overall response rate was 66%: CR 13%, vgPR 27% and PR 26%. Median time to response was 35 days and median time to progression was 9.3 months. Common adverse events included cytopenias, peripheral neuropathy and infections. No patient experienced deep-vein thrombosis. VMDT reduced angiogenic cytokines, osteoclast regulators, dickkopf-1 and bone resorption. We conclude that VMDT with intermittent thalidomide is an active and well-tolerated regimen for relapsed/refractory myeloma, affecting abnormal bone remodeling and angiogenesis.

The present study investigates the principal morphological and sedimentological (textural) characteristics of the beach-zones along the Tigani and Mikalis Bays, which are located at the southeastern coast of Samos Island. It is also examined their retreat due to the expected sea level rise induced by the climatic change. The beach zones under investigation has been formed in front of alluvial coastal plains, while at their western end host the mouth of small (ephemeral) rivers. Their width varies between 12 and 25 m, becoming narrower towards their eastern ends; this shows that the longshore sediment transport, which is from W to E due to their coastline orientation relatively to incoming waves, has not been strong enough to move most of the sediment eastwards. The subaerial part of both beach zones consists of gravels, while their subaqueous part is covered by sand. The presence of low dunes at the backshore odf the Thiogani Bay in association with the lack of sand between the dunes and the shoreface indicate that the beach zone is under erosion. Furthermore, with respect to the expected sea-level rise the shoreline of Tigani bay may be retreat by 15-20 m, when the nearby shoreline of Mikalis bay could retreat 12-15 m.

In the context of the Kaleidoscope Network of Excellence, six European research teams developed a methodology for integrating their research approaches. In this paper, we present the methodology based on a cross-experimentation, showing how it gave insight to the understanding of each team’s research and on the relationship between theoretical frameworks and experimental research.

BACKGROUND: The objective of this study was to compare total costs of care and its major components for community-living patients with Alzheimer's disease (AD) or dementia with Lewy bodies (DLB). This cross-sectional analysis of baseline data from the Predictors II Study took place in three university-based AD centers in the U.S. METHODS: Community-living patients clinically diagnosed with probable AD (n = 170) or DLB (n = 25) with a modified Mini-Mental State examination (mMMS) score > or =30, equivalent to a score of approximately > or =16 on the Folstein Mini-Mental State Examination (MMSE), participated in this study. Patient and informant reported on patients' use of direct medical care, direct nonmedical care, and informal care. Patients' clinical and demographic characteristics included global cognitive status (measured by MMSE), functional capacity (measured by Blessed Dementia Rating Scale), psychotic symptoms, behavioral problems, depressive symptoms, extrapyramidal signs, comorbidities, age, and sex. Costs were compared by using covariate matching methods. RESULTS: Unadjusted total costs and direct medical costs were not significantly different between AD and DLB patients. Compared with AD patients, unadjusted indirect costs were significantly higher and unadjusted direct nonmedical costs were significantly lower among DLB patients. After adjusting for age, sex, cognitive and functional status, differences in all cost components between DLB and AD patients were no longer statistically significant. CONCLUSIONS: Apparent cost differences were largely attributed to differences in patients' cognitive and functional status. However, the small sample size for DLB patients might have limited power to detect statistically significant differences in costs of care between these groups.

BACKGROUND: Discrepancies in primary health care (PHC) services between urban and rural settings have already been studied in many countries; however, limited information exists regarding countries, such as Greece, where public Health Centres dedicated to primary care have not been in existence in major cities. The objective of this study was to evaluate points of divergence or convergence between an urban and a rural health centre, in an attempt to underline challenges faced by the introduction of urban health centres in Greece. METHODS: A cross-sectional analysis was conducted in the Health Centre of Vyronas, Athens, Greece and in the Health Centre of Nea (New) Madytos, Thessaloniki Prefecture, Greece between February 2004 and February 2006. The profile of the population seeking care, as well as data on the services provided were collected and compared. In addition, the reason for choosing each primary health care unit was also recorded. RESULTS: More patients visited the urban centre (145415 vs. 112513), while the pattern of services utilized by the citizens differed significantly (p < 0.001) between the two Health Centres. The frequency of diagnoses made according to ICPC-2 was not similar in the two Health Centres (p < 0.001). The three most frequent reasons for the adults choosing the Health Centre for their problem were low waiting time, proximity to residence and satisfaction with the services provided in previous visits in Vyronas. CONCLUSION: The results of this study highlight the significant differences regarding PHC services utilization between an urban and a rural population. Urban citizens seem to have different health needs and reasons for choosing a PHC unit than residents of the Greek countryside. Proximity to health services and the public character of the urban health centre seem to be its main advantages.

The authors theoretically demonstrate a practical scheme for robust and complete photonic bandgap switching using a three-dimensional double-inverse-opal photonic crystal. The investigated structure consists of a close-packed face-centered-cubic arrangement of spherical air pores, interconnected via air channels and embedded in a high-index (tin disulfide) backbone. We show that by placing lower-index movable dielectric scatterers (titania) inside the air pores, a complete photonic bandgap opens for certain positions of the scatterers, which altogether closes for other positions. Our analysis reveals that this switching scheme is robust to geometric imperfections and allows for sizeable bandgap switching. © 2008 American Institute of Physics.

The complete mitochondrial DNA (mtDNA) sequence was determined for the phytopathogenic fungus Fusarium oxysporum. It is 34,477 bp long, maps circularly, and encodes for 14 protein-coding, 25 tRNA and 2 rRNA genes. The nucleotide and amino acid data sets from its 14 concatenated protein-coding mitochondrial (mt) genes were used along with gene order comparisons for an extensive phylogenetic study of the Subphylum Pezizomycotina. Our results are in agreement with current taxonomic treatments and additionally provide better statistical support for all relationships within Pezizomycotina when compared to analyses based on single or few gene data sets. The gene order of F. oxysporum was consistent with that established in the order Hypocreales (Class: Sordariomycetes) and enhanced previous suppositions on the ancestral state of Sordariomycetes. In comparison with mt genomes of the other orders it added further insights to the evolution of Pezizomycotina.

The mtDNA of the ascomycetous wine yeast Candida zemplinina is a circularly mapping genome of 23,114 bp. It contains 35 genes coding for the seven basic subunits of oxidative phosporylation found in yeasts (the genes encoding for NADH oxidoreductase subunits are absent), the ribosomal protein Var1, two rRNAs and 25 tRNA genes. Although protein phylogenetic analysis showed a divergent mitochondrial genome, several traits appeared preserved. The conserved gene blocks between the mtDNAs of C. zemplinina and Candida glabrata were maintained and changes in gene order and putative promoters were due to restricted genome reshuffling. New heterogeneous hairpin elements were identified scattered throughout cox1 introns. The large subunit rRNA gene harboured the first group-IIB1 intron containing a putative active reverse transcriptase (RT) in mitochondrial genomes of fungi. Phylogenetic analysis of the RT protein confirmed its closer relationship to eubacterial intronic RTs, while being only distantly related to all other fungal mitochondrial group-II introns and RTs. The findings point towards an early migration event of a eubacterial group-II intron to the mitochondrial genome of C. zemplinina.

INTRODUCTION: Clinical assessment of facial type and facial proportions is an important element of orthodontic diagnosis and subsequent treatment planning. Because of the subjective nature of this procedure, it is important to identify factors that could affect final judgment. One such factor that has been shown to affect facial perception in general might be the configural relationship of internal parts of the face. Our aim in this study was to assess whether configural changes in a face affect the subjective evaluation of facial type. METHODS: The frontal photographs of 2 white boys, aged 12 years, with harmonious face were used. The photographs were manipulated by computer to produce realistic images of faces with various configural relationships of the features. The modifications were interocular distance enlarged by 3 mm or reduced by 3.6 mm, mouth width enlarged by 4.5 mm or reduced by 4.2 mm, and mouth moved vertically upward or downward by 2.8 mm. Two images with a true change of the frontal facial height by 4 mm were also produced. The images were presented in pairs to 20 experienced orthodontists. Each judge evaluated 36 pairs of images (including pairs of identical images), all belonging to the same patient, in a random sequence. The judges were unaware of the changes that had been made to the photographs and were asked to evaluate which of the 2 faces appeared longer. RESULTS: The judges correctly identified pairs of identical images with an accuracy of 42%. Reduction of the interocular distance and downward movement of the mouth caused the illusion of a longer face. The opposite changes had the reverse effect. Enlargement of the width of the mouth did not appear to influence the subjective impression of facial type, but reduction of mouth width had a statistically significant result, giving the impression of a longer face. CONCLUSIONS: Configural relationships among the constituent features of a face can influence our judgment about external facial proportions. Because of the importance of these factors in treatment planning, clinical evaluation of faces should be accompanied by objective assessment (measurement) of photographs, so that any illusory visual effects can be identified.

The essays collected in this volume – the outcome of the EAAS convention in Cyprus in 2006 – form a crossroads between a number of disciplines (literary theory and criticism, film studies, history, cultural studies, sociology); they are all animated – in different ways and to different extents – by a healthy suspicion towards the idea that the concepts of conformism, non-conformism and anti-conformism are transhistorically static or transcendentally self-evident. The conceptual contours of the subject are investigated before the topic is then explored in historical perspective, in its textual manifestations, and with regard to its stakes in visual culture. The collection is rounded off with a critical glance at commercial aspects of conformism and anti-conformism. The volume includes essays by Donald Pease, Heinz Ickstadt, Susana Delfino, Albena Bakratcheva, Marek Wilczynski, Johannes Völz, Marc Amfreville, Andrew S. Gross, Yves-Charles Grandjeat, Thomas Pughe, Susanne Rohr, Peter Loizos, Dimitris Liokaftos, Hilaria Loyo, Alexandra Ganser and Karin Hoepker, Frank Mehring, Berndt Ostendorf, and Arthur Redding.

Purpose– Corporate governance (CG) has mainly focused on highly dispersed corporations. This paper has two objectives: to enrich the debate in this area and to contribute to the increasing body of literature by exploring the CG of the listed family firms in Greece; and to place the CG practices of Greek family firms within the international debate, especially in the framework of a small open capital market. In addition, this paper presents an attempt to quantify the compliance of family firms with international best practices. Design/methodology/approach– The methodology consisted of the creation of a questionnaire reflecting the Greek CG code and other well‐regarded CG codes, like the OECD principles. The authors constructed a CG rating system and applied it to distinguish family from non‐family firms. Findings– The main conclusion is that the family firms lack an efficient CG mechanism and they demonstrated poor governance compared with non‐family firms. Practical implications– The results disclose the potential strengths and weaknesses of the existing CG framework of the family‐owned firms. The methodology applies in a small open economy and may have significant implications in other similar capital markets. Originality/value– Methodologically, the merit of the exercise lies in its approach toward the creation of “collectively subjective” weightings, and is valuable to policymakers and academics.

Background: Several cytokines have been associated with immune regulation and prognosis in ovarian cancer. CD4+CD25+ Tregs and CD3+CD56+ NK-like T cells are involved in the immune response against the tumor. We have investigated the association of cytokines in the ascites from patients with ovarian cancer with these populations, the platinum resistance and the prognosis of these patients. Patients and methods: Ascites from 64 patients with ovarian cancer was analysed. Forty-two patients were studied at diagnosis (FIGO stage III in 40 cases) and were treated with cytoreductive surgery and platinum-based chemotherapy. Ascites from 9 patients with cirrhosis was used as control. Vascular endothelial growth factor (VEGF), tumor necrosis factor-α (TNFα), interferon-gamma (IFNγ), inteleukin-10 (IL10) and interleukin-12 (IL12) in ascites and serum were measured by enzyme-linked immunosorbent assay (ELISA), while lymphocytic populations were studied with three-colour flow cytometry. Results: VEGF ascites levels were inversely correlated with CD3+CD56+ cells (rho = - 0.316, p = 0.012), while a similar correlation was observed between TNFα ascites levels and CD4+CD25+(hi) cells (rho = - 0.332, p = 0.041). Among patients receiving first-line chemotherapy, VEGF levels < 1900 pg/ml and TNFα levels > 35 pg/ml were associated with platinum sensitivity (p = 0.021 and p = 0.028, respectively) and improved progression-free survival (PFS) (p = 0.007 and p = 0.045, respectively). Low VEGF levels were also associated with improved overall survival (p = 0.026). Conclusion: VEGF and TNFα ascites levels are associated with prognosis in advanced ovarian cancer. Their prognostic significance may be due to their association with immunologically important populations, namely the NK T-like CD3+CD56+ cells and the Tregs CD4+CD25+(hi) cells. © 2007 Elsevier Inc. All rights reserved.

Il reste juste à souligner qu’en ce qui concerne la terminologie arbitraire du discours en apparence historique ou géographique, la responsabilité n’incombe ni à l’Histoire ni à la Géographie, mais à ceux qui se prétendent historiens ou géographes. La question est posée en ces termes chez Gearóid Ó Tuathail (dorénavant G.T.) et son essai intitulé Critical Geopolitics (Géopolitique Critique).1 Il s’agit d’un ouvrage ambivalent, qui présente au lecteur d’une part le plaisir intellectuel de pouvoir trouver et identifier des événements internationaux, méticuleusement groupés en catégories d’ordre chronologique, accompagnés d’une analyse intelligente en fonction de leurs éléments constitutifs, à savoir des données économiques, idéologiques et culturelles. D’autre part, nous autres lecteurs avons eu la satisfaction d’y retrouver en partie nos propres analyses sur les événements présentés par G.T. sans que cela ne nous pose un certain nombre de questions. Tout de même, pour l’auteur du présent article, l’analyse géopolitique n’a pas d’idéologie, ni de fixations ethnocentriques; elle n’est pas sous le contrôle des éléments nationalistes qui rendent service aux impérialismes des Métropoles contemporaines.

We tested 27 microsatellite loci for cross-species amplification in the lacertids Podarcis gaigeae and Podarcis hispanica. We detected 11 and 15 polymorphic loci in the former and the latter species, respectively. In a larger sample of individuals from a single population of each species, the number of alleles ranged from five to 23 in 10 of the polymorphic loci in P. gaigeae, and between four and 13 in nine of polymorphic loci in P. hispanica. Two locus deviated from Hardy-Weinberg equilibrium in P. hispanica. Between 11 and 16 of the 27 loci also amplified successfully in three other Podarcis species. © 2008 The Authors.

BACKGROUND: Cutaneous lesions in myelodysplastic syndrome (MDS) may be specific or not and may reveal bone marrow transformation. Our purpose was to investigate in a cohort of 84 MDS patients the correlation of cutaneous findings with immunologic parameters and prognostic features of MDS in order to clarify their potential clinical significance. MATERIALS AND METHODS: We studied a cohort of 84 newly diagnosed MDS patients in order to assess the cutaneous findings present at the time of diagnosis and during 1 to 3 years of follow-up. We described the clinical variety of cutaneous findings ascertained by histology. We also looked for any association between the group of MDS patients with skin manifestations and MDS subtype, immunologic and prognostic features highlighting transformation to acute leukaemia. RESULTS: Twenty-one patients presented cutaneous manifestations: 1 patient developed leukaemia cutis, 6 patients photosensitivity not associated with autoimmune disease, 3 prurigo nodularis, 2 Sweet's syndrome, 6 leucocytoclastic vasculitis, 2 ecchymoses and purpura associated with preexisting relapsing polychondritis, 1 patient subcutaneous nodules associated with Wegener's granulomatosis and 1 patient with malar rash and oral ulcers associated with preexisting systemic lupus erythematosus. Adjusted for age and gender, the presence of skin findings constitutes a significant predictor of the high-risk MDS subgroup (odds ratio, 3.59; 95% confidence interval, 1.18-10.92). Hypergammaglobulinemia was significantly higher in the MDS subgroup with skin manifestations (P = 0.03). CONCLUSION: Most MDS patients with cutaneous manifestations belong to the high-risk MDS subgroup and present hypergammaglobulinemia. Early biopsy of skin lesions in myelodysplasia is indicated.

WHEN CITING:   

1. Καμπερίδου, Ρένα (2008). Το 'Σκοτεινό' Κοινωνικό Κεφάλαιο του Αθλητισμού:  η γυάλινη οροφή και  'ο αγωγός διαρροής' .  Ημερίδα «Γυναίκες και Αθλητισμός», Πάντειο Πανεπιστήμιο Κοινωνικών και Πολιτικών Επιστημών του Διατμηματικού Προγράμματος Σπουδές Φύλου και Ισότητας στις Κοινωνικές και Πολιτικές Επιστήμες, αμφιθέατρο "Σάκη Καράγιωργα", Πάντειο Πανεπιστήμιο, Λ. Συγγρού 136, Νέο Κτήριο, 11 Ιουνίου 2008. DOI: 10.13140/RG.2.1.2277.3600 , ΒΙΒΛΙΟ ΠΡΑΚΤΙΚΩΝ Ι.2.1 in Apella Επίσης βλ. http://www.genderpanteion.gr/gr/2008pdf/imerida11062008.pdf    

•  Kamberidou, I. (2008). 'Dark' Social Capital in Sport: the glass ceiling and the leaky pipeline. Presentation [keynote speaker: http://www.genderpanteion.gr/gr/2008pdf/imerida11062008.pdf] at the “WOMEN AND SPORT” Seminar, Panteion University of Social and Political Sciences. Gender Studies Centre of Panteios University, Athens, Greece: http://www.genderpanteion.gr/gr/2008pdf/imerida11062008.pdf , http://www.genderpanteion.gr/gr/dialsem\_im.php [presentation in Greek].  I.2  in Apella. Also see I.2.2 in Apella), and Book of Abstracts in Ι.2.1

The changes in daily precipitation totals in Greece, during the 45-year period (1957–2001) are examined. The precipitation datasets concern daily totals recorded at 21 surface meteorological stations of the Hellenic National Meteorological Service, which are uniformly distributed over the Greek region. First and foremost, the application of Factor Analysis resulted in grouping the meteorological stations with similar variation in time. The main sub groups represent the northern, southern, western, eastern and central regions of Greece with common precipitation characteristics. For representative stations of the extracted sub groups we estimated the trends and the time variability for the number of days (%) exceeding 30 mm (equal to the 95% percentile of daily precipitation for eastern and western regions and equal to the 97.5% percentile for the rest of the country) and 50 mm which is the threshold for very extreme and rare events. Furthermore, the scale and shape parameters of the well fitted gamma distribution to the daily precipitation data with respect to the whole examined period and to the 10-year sub periods reveal the changes in the intensity of the precipitation.

This study presents results of ambient noise measurements carried out in 78locations in the town of Lefkada. The horizontal-to-vertical spectral ratios of ambient noise were used to approximate the fundamental resonance frequencies of the subsurface and their associated amplitudes. Summarizing the experiences of different authors with respect to ambient vibration processing, we selected transient free time windows for further analysis. Additionally, we calculated the site responses with respect to the reference site and compared the results with those obtained from the H/V technique. The fundamental frequency and the corresponding amplification factor were calculated for each site. Under the assumption that the H/V spectral ratios of ambient noise coincide with the amplification levels at the dominant frequency of the site response functions, the fundamental frequencies (f0) and amplification factors (A0) were compiled on ARC-INFO GIS software and corresponding maps were developed.

A reaction-limited model for drug dissolution is developed assuming that the reaction at the solid-liquid interface is controlling the rate of dissolution. The dissolution process is considered as a bidirectional chemical reaction of the undissolved drug species with the free solvent molecules, yielding the dissolved species of drug complex with solvent. This reaction was considered in either sink conditions, where it corresponds to the unidirectional case and the entire amount of the drug is dissolved, or reaching chemical equilibrium, which corresponds to saturation of the solution. The model equation was fitted successfully to dissolution data sets of naproxen and nitrofurantoin formulations measured in the paddle and basket apparatuses, respectively, under various experimental conditions. For comparative purposes these data were also analyzed using three functions based on the diffusion layer model. All functions failed to reveal the governing role of saturation solubility in the dissolution process associated with the diffusion layer model when the conditions for the valid estimation of saturation solubility, established theoretically in this study, were met by the experimental set up employed. Overall, the model developed provides an interesting alternative to the classic approaches of drug dissolution modeling, quantifying the case of reaction-limited dissolution of drugs. (c) 2007 Elsevier B.V. All rights reserved.

INTRODUCTION Plasma cell dyscrasias include a wide variety of diseases characterized by the abnormal accumulation of plasma cells resulting in various systemic symptoms and signs. Plasma cells are usually widespread throughout the bone marrow; however, in a minority of patients malignant plasma cells may form a single lesion. These lesions are usually confined to the bone and, less frequently, in extramedullary sites. They are composed of monoclonal plasma cells that are otherwise identical to plasma cells found in myeloma. However, these patients do not have evidence of systemic multiple myeloma (MM), and an extensive work up shows no other foci of disease. When this solitary lesion is confined to bone it is characterized as a solitary bone plasmacytoma (SBP) while when this lesion is confined to extraosseous sites it is characterized as a solitary extramedullary plasmacytoma (SEP). DEFINITIONS According to criteria reported by the International Myeloma Working Group, diagnosis of solitary plasmacytoma of bone is based on histological evidence of a tumor consisting of monoclonal plasma cells identical to those seen in MM (Table 12.1). In addition, complete skeletal radiographs must show no other lesions of MM. Magnetic resonance imaging (MRI) has significantly increased sensitivity over conventional radiographs, especially in the imaging of the axial skeleton, and an MRI of the spine and pelvis may show unsuspected and asymptomatic skeletal lesions. Patients with multiple lesions in MRI should be considered as having myeloma and not SBP even if conventional radiographs show no other evidence of skeletal involvement. © Cambridge University Press 2009.

OBJECTIVE: The aim of this study was to investigate possible differences in eating disorder symptomatology between a group of athletes and a group of university students as well as to investigate the risk factors for developing of eating disorders symptomatology in females. METHOD: The EAT-26, BDI, STAI and SPAS (trait) questionnaires were administered to 60 adult athletes (27 female and 33 male) and 60 non-athlete university students (40 female and 20 male). Each subject was asked to indicate on a series of 12 male and 12 female human figures those that they considered as the ideal male and female body, and the figure that in their mind resembled most their own body. The body mass index (BMI) was calculated for each subject. RESULTS: Male athletes scored higher in the oral control dimension of EAT-26 than male non athletes. Female athletes also perceived their body as leaner than female non-athletes did (P=0.003), although there was no statistically significant difference between the BMI of the two groups. A subgroup of women (n=7, 10.4%) who had disordered eating attitudes (EAT >20) chose leaner ideal female figures and also scored higher on the BDI, STAI trait and SPAS questionnaires. Younger age (P=0.04), being an athlete (P=0.03) and SPAS score (P=0.02) were found in logistic regression analysis to influence significantly the risk of development for developing disordered. CONCLUSIONS: There were only minor differences in eating disorder measurements between athletes and non-athletes. A small group of young women who are preoccupied with their physical appearance and are involved in athletic activities appears to run a greater risk for developing disordered. Copyright © Athens Medical Society.

INTRODUCTION: Access to local providers of primary health care (PHC) services and their utilisation is a challenge faced by the authorities of developed as well as developing countries. The aim of our study was to assess and evaluate the level of satisfaction with the currently provided cardiovascular and PHC services in the southernmost region of continental Greece (and of the European Union), Southern Mani. METHODS: The sample (422 individuals, 375 of whom finally participated: 187 men and 188 women, response ratio: 88.86%), was selected between January-December 2006, using stratified randomisation by sex and age. Participants were asked to fill in a validated questionnaire containing socio-demographic data and items about the health needs/level of satisfaction with cardiovascular health and PHC services, as well as two indices for cardiovascular health: i) frequency of international normalised ratio (INR) measurement in case of atrial fibrillation, and ii) history of timely thrombolysis in case of acute myocardial infarction. RESULTS: The majority of the responders stated that their level of satisfaction with PHC services was "low" or "very low" (total: 52.80%), while the percentage of dissatisfaction with cardiovascular health services was 56.0%. In addition, most of the participants expressed a strong wish for improvement of PHC services (71.33%). The level of satisfaction with PHC services was higher than with cardiovascular health services (2.49 +/- 1.26 vs. 2.38 +/- 1.24; p < 0.001). Satisfaction scores for both cardiovascular health and PHC services were negatively associated with the distance from the nearest PHC Unit. Only 11.1% of patients (95% CI: 0.3%-48.2%) reported annual testing of prothrombin time more than once, while among those with a history of acute myocardial infarction, none reported timely thrombolysis (0%, one-sided 97.5% CI: 0%-41.0%). CONCLUSION: It is evident that a large portion of the Southern Mani population perceives the provided cardiovascular health and PHC services as problematic, while the distance from the nearest PHC unit seems to be one of the most important factors and predictors of dissatisfaction. The provision of efficient PHC services in isolated areas is a matter that should be re-evaluated.

OBJECTIVE: To determine whether beta-amyloid (Abeta) peptides segregated into distinct biochemical compartments would differentially correlate with clinical severity of Alzheimer disease (AD). DESIGN: Clinicopathologic correlation study. PARTICIPANTS: Twenty-seven patients from a longitudinal study of AD and 13 age- and sex-matched controls without a known history of cognitive impairment or dementia were included in this study. INTERVENTIONS: Temporal and cingulate neocortex were processed using a 4-step extraction, yielding biochemical fractions that are hypothesized to be enriched with proteins from distinct anatomical compartments: TRIS (extracellular soluble), Triton (intracellular soluble), sodium dodecyl sulfate (SDS) (membrane associated), and formic acid (extracellular insoluble). Levels of Abeta(40) and Abeta(42) were quantified in each biochemical compartment by enzyme-linked immunosorbent assay. RESULTS: The Abeta(42) level in all biochemical compartments was significantly elevated in patients with AD vs controls (P < .01). The Abeta(40) levels in the TRIS and formic acid fractions were elevated in patients with AD (temporal, P < .01; cingulate, P = .03); however, Triton and SDS Abeta(40) levels were similar in patients with AD and in controls. Functional impairment proximal to death correlated with Triton Abeta(42) (r = 0.48, P = .02) and SDS Abeta(42) (r = 0.41, P = .04) in the temporal cortex. Faster cognitive decline was associated with elevated temporal SDS Abeta(42) levels (P < .001), whereas slower decline was associated with elevated cingulate formic acid Abeta(42) and SDS Abeta(42) levels (P = .02 and P = .01, respectively). CONCLUSION: Intracellular and membrane-associated Abeta, especially Abeta(42) in the temporal neocortex, may be more closely related to AD symptoms than other measured Abeta species.

Several examples of oxidative and reductive reactions of DNA components that lead to single and tandem modifications are discussed in this review. These include nucleophilic addition reactions of the one-electron oxidation-mediated guanine radical cation and the one-electron reduced intermediate of 8-bromopurine 2'-deoxyribonucleosides that give rise to either an oxidizing guanine radical or related 5',8-cyclopurine nucleosides. In addition, mechanistic insights into the reductive pathways involved in the photolyase induced reversal of cyclobutadipyrimidine and pyrimidine (6-4) pyrimidone photoproducts are provided. Evidence for the occurrence and validation in cellular DNA of ̇OH radical degradation pathways of guanine that have been established in model systems has been gained from the accurate measurement of degradation products. Relevant information on biochemical aspects of the repair of single and clustered oxidatively generated damage to DNA has been gained from detailed investigations that rely on the synthesis of suitable modified probes. Thus the preparation of stable carbocyclic derivatives of purine nucleoside containing defined sequence oligonucleotides has allowed detailed crystallographic studies of the recognition step of the base damage by enzymes implicated in the base excision repair (BER) pathway. Detailed insights are provided on the BER processing of non-double strand break bistranded clustered damage that may consist of base lesions, a single strand break or abasic sites and represent one of the main deleterious classes of radiation-induced DNA damage. © Schweizerische Chemische Gesellschaft.

In the present study an assessment of the influence of the ambient air pollution on the incidence of the Childhood Asthma Admissions (CAA) is attempted by using cross spectrum analysis. The medical data concern the hospital registries of the three main Children's Hospitals of Athens for the 14-year period, 1987-2000. The air pollution data used in this study were mean monthly concentrations of CO, Black Smoke (BS), NOx, SO2, and O3, averaged over all the available stations, for each air pollutant, in the network of the Greek Ministry of the Environment, Physical Planning and Public Works (GMEPPPW) for the aforementioned 14-year period. The performed analysis revealed that a pronounced seasonal variation of asthma exacerbation among Athenian children does exist, rising during the cold damp period in pre-schoolers and peaking around May in the schoolchildren. We found that asthma admissions are associated with ambient air pollution at different frequencies. Asthma exacerbation among the first age group (0-4 years) is strongly depended on winter air pollution whereas older children (5-14 years) appear to be more vulnerable to the exposure of primary air pollutants mainly during late spring. Our findings strengthen the aspect that weather conditions such as sea breeze, mainly happen at the late spring or early summer in association with air pollution episodes could affect childhood asthma exacerbation. © 2008 Global NEST Printed in Greece. All rights reserved.

In this paper we are examining the state of Naxos Island as far as erosion is concerned, using precipitation indexes produced from daily precipitation totals and Geographical Information System (GIS) in order to develop an erosion risk model. Naxos Island belongs to the Cycladic area and is situated at the central Aegean Sea, in Greece. The relief of the island is mountainous, with a central mountain chain crossing it from north to south. The geology of Naxos is characterised by a migmatite irruption, metamorphic rocks (schist, gneiss, marble), and sedimentary rocks (Neogenic and Quaternary deposits). Tectonism of the area is low nowadays but in the past geological time has played a major role defining the present morphology. Although the mean annual precipitation appear to be low (~360.0 mm), the erosion processes of the area are very intense, because of the intensive character of precipitation, the high slope relief, the differential lithology and the absence of important land cover. The aforementioned factors are the major contributing to the formation of the present denudated morphology mainly because of the intense run off.

Dye-sensitized solar cells (DSSCs) were prepared using TiO2 nanotubes, grown by controlled Ti anodic oxidation in non-aqueous media. Smooth, vertically oriented TiO2 nanotube arrays, presenting a high degree of self-organization and a length of 20 μm, have been grown using ethylene glycol electrolyte containing HF. As-grown nanotubes exhibit an amorphous structure, which transforms to the anatase TiO2 crystalline phase upon post-annealing in air at 450°C. Atomic force microscopy (AFM) revealed the porous morphology together with high roughness and fractality of the surface. The annealed tubes were sensitized by the standard N719 ruthenium dye and the adsorption was characterized using resonance micro-Raman spectroscopy and adsorption-desorption measurements. The sensitized tubes were further used as active photoelectrodes after incorporation in sandwich-type DSSCs using both liquid and solidified electrolytes. The efficiencies obtained under air mass (AM) 1.5 conditions, using a back-side illumination geometry, were very promising: 0.85% using a composite polymer redox electrolyte, while the efficiency was further increased up to 1.65% using a liquid electrolyte. © IOP Publishing Ltd.

BACKGROUND: E2F-1 expression is positively associated with tumour growth in oesophageal squamous-cell carcinomas (OSCC), while it exhibits oncosuppressive features in colonic adenocarcinomas (AC). To date there are no data regarding E2F-1 expression and its relationship with tumour kinetics (proliferation, apoptosis) in adenocarcinomas that develop on Barrett oesophagus. AIM: As oesophageal adenocarcinomas occur almost exclusively in the metaplastic Barrett epithelium and the opposing E2F-1 behaviour seems to be cell and tissue-type dependent, we examined the manner in which E2F-1 acts in ACs of Barrett oesophagus. METHODS: We estimated the immunohistochemical expression of E2F-1, Ki-67, caspase-3 and p53 immunohistochemical status in 35 Barrett oesophagus ACs. RESULTS: E2F-1 immunopositivity correlated inversely with Ki-67, by semi-serial section and statistical analysis (p = 0.023, Spearman correlation). Semi-serial section analysis revealed a direct association between E2F-1 and caspase-3 staining. No correlation was found with p53 status. Cases with higher E2F-1 immunoexpression exhibited longer survival (p = 0.047, Cox-regression). CONCLUSIONS: E2F-1 expression was negatively related to tumour proliferation in ACs of Barrett oesophagus. Additionally, E2F-1 immunohistochemical status correlated positively with patient survival. These findings are opposite from those seen in OSCCs, suggesting that the tumour-suppressing E2F-1 behaviour in oesophageal adenocarcinomas is possibly due to the intestinal-type nature of the metaplastic Barrett mucosa.

Gender-constrained educational choices, traditional-anachronistic perspectives, the life-work balance or rather imbalance, the lack of affordable child care facilities, the glass ceiling, the leaky pipeline, among other things, have contributed to the declining interest of Greek women in science and technology. This paper focuses on the factors that contribute to Greek women’s non-engagement or under-representation in ICT related fields, such as computing. It examines the gender-constrained institutions in Greece while providing an overview of the gender distribution in scientific research and in the Greek academia, where only about one third (27%) of the teaching staff in universities are women. Digital illiteracy has been detected amongst university students in Greece, over half of which are women, as well as amongst primary and secondary school teachers throughout the country who explicitly express a technophobic unwillingness to use computers in their classrooms, although they claim to agree on their significant educational value and usefulness. Although the Greek Ministry of Education had implemented the training of 76,000 teachers in ICTs, it seems to have failed to reach the aspired levels of effectiveness, in a society where the participation of women in the teaching profession—primary and secondary education—is over 50%. The majority of the respondents from rural, agricultural,  urban areas of Greece claim that they have not benefited by the technology classes or computer lessons they had received in high school, and not only. The gender variable plays a decisive role in the development of attitudes, i.e. the use of computers or the internet as a tool may be gender-neutral, however access to and motivation of use is gender-constrained. The Greek public school system’s inadequate technological infrastructures, deficiencies in the vocational orientation of students and the continuous techno-education of teachers, the lack of collaboration of the education system with the employment sector and the ICT industry— along with the family-career imbalance, namely the incompatibility of private life and career which is essentially a female problem— have made it impossible for the gender subject to keep up with the accelerated speed of technological developments. An ‘Education-Engagement-Retention Action Plan’ is required to change attitudes and promote women in science and technology, in the academia, etc.: (1) Child care facilities, flexi-hours, family support programmes, and a family-friendly working environment. (2) The establishment of an attractive open labour market that recruits and retains women in science and technology.

DOI: 10.13140/RG.2.1.2821.0725Full pdf (proceedings and article) in Research Gate (RG)--------------------------------------------------------------------------------------------------------- Gender-constrained educational choices, traditional-anachronistic perspectives, the life-work balance or rather imbalance, the lack of affordable child care facilities, the glass ceiling, the leaky pipeline, among other things, have contributed to the declining interest of Greek women in science and technology. This paper focuses on the factors that contribute to Greek women’s non-engagement or under-representation in ICT related fields, such as computing. It examines the gender-constrained institutions in Greece while providing an overview of the gender distribution in scientific research and in the Greek academia, where only about one third (27%) of the teaching staff in universities are women. Digital illiteracy has been detected amongst university students in Greece, over half of which are women, as well as amongst primary and secondary school teachers throughout the country who explicitly express a technophobic unwillingness to use computers in their classrooms, although they claim to agree on their significant educational value and usefulness. Although the Greek Ministry of Education had implemented the training of 76,000 teachers in ICTs, it seems to have failed to reach the aspired levels of effectiveness, in a society where the participation of women in the teaching profession—primary and secondary education—is over 50%. The majority of the respondents from rural, agricultural,  urban areas of Greece claim that they have not benefited by the technology classes or computer lessons they had received in high school, and not only. The gender variable plays a decisive role in the development of attitudes, i.e. the use of computers or the internet as a tool may be gender-neutral, however access to and motivation of use is gender-constrained. The Greek public school system’s inadequate technological infrastructures, deficiencies in the vocational orientation of students and the continuous techno-education of teachers, the lack of collaboration of the education system with the employment sector and the ICT industry— along with the family-career imbalance, namely the incompatibility of private life and career which is essentially a female problem— have made it impossible for the gender subject to keep up with the accelerated speed of technological developments. An ‘Education-Engagement-Retention Action Plan’ is required to change attitudes and promote women in science and technology, in the academia, etc.: (1) Child care facilities, flexi-hours, family support programmes, and a family-friendly working environment. (2) The establishment of an attractive open labour market that recruits and retains women in science and technology.

Currants and Sultanas (Vitis vinifera L.) are dried vine products produced in Greece and used broadly in the Mediterranean diet. We aimed to investigate the gastric cancer preventive activity of methanol extracts obtained from currants from three different origins in Greece (Vostizza, Nemea, and Messinia) as well as methanol extracts obtained from Sultanas cultivated in the island of Crete as to inhibition of cell proliferation, induction of apoptosis, and inhibition of inflammation. All extracts from 500 microg dried raisins studied suppressed cell proliferation, significantly those obtained from Sultanas from Crete and currants from Nemea. Flow cytometric analysis of Annexin-V labeled cells indicated that Cretan Sultana, Nemea, and Messinia currants at 500 microg dried product/ml medium significantly induced cell death. All extracts from 500 microg dried raisins statistically decreased protein and mRNA levels of ICAM-1 in TNF-alpha stimulated cells. Measurement of IL-8 protein levels and quantification for IL-8 mRNA showed no significant decrease. These results indicate that the methanol extracts from currants, rich in phenolic compounds, exhibit cancer preventive efficacy by limiting cell proliferation, inducing cell death, and suppressing ICAM-1 levels in AGS cells.

Based on an analytical expression for the photoluminescence (PL) intensity of individual quantum dots (QDs) in the linear regime, we investigate its dependence upon the size of self‐assembled InGaAs QDs. We prove that decreasing the QD size, the PL‐emission spectrum moves to higher energy, due to the confinement‐induced blue‐shift of the electronic levels and the redshift from the increased Coulomb interaction caused by the compression of the exciton radii. This shift is in agreement with experimental results. Moreover, we show that larger dots provide more intense PL spectra.

The aim of this study was to determine whether there is any association between weather variability and asthma admissions among children in Athens, Greece. Medical data were obtained from hospital registries of the three main Children's Hospitals in Athens during the 1978-2000 period; children were classified into two age groups: 0-4 and 5-14 years. The application of Generalized Linear Models with Poisson distribution revealed a significant relationship among asthma hospitalizations and the investigated parameters, especially for the children aged 0-4 years. Our findings showed that Hospital admissions for childhood asthma in Athens, Greece, is negatively correlated with discomfort index, air temperature and absolute humidity whereas there is a positive correlation with cooling power, relative humidity and wind speed. Copyright © 2008 Informa Healthcare USA, Inc.

Seven 6 s sprints with 30 s recovery between sprints were performed against two resistive loads: 50 (L50) and 100 (L100) g · kg-1 body mass. Inertia-corrected and -uncorrected peak and mean power output were calculated. Corrected peak power output in corresponding sprints and the drop in peak power output relative to sprint 1 were not different in the two conditions, despite the fact that mean power output was 15-20% higher in L100 (P < 0.01). The effect of inertia correction on power output was more pronounced for the lighter load (L50), with uncorrected peak power output in sprint 1 being 42% lower than the corresponding corrected peak power output, while this was only 16% in L100. Fatigue assessed by the drop in uncorrected peak and mean power output in sprint 7 relative to sprint 1 was less compared with that obtained by corrected power values, especially in L50 (drop in uncorrected vs. corrected peak power output: 13.3 ± 2.2% vs. 23.1 ± 4.1%, P < 0.01). However, in L100, the difference between the drop in corrected and uncorrected mean power output in sprint 7 was much smaller (24.2 ± 3.1% and 21.2 ± 2.7%, P < 0.01), indicating that fatigue may be safely assessed even without inertia correction when a heavy load is used. In conclusion, when inertia correction is performed, fatigue during repeated sprints is unaffected by resistive load. When inertia correction is omitted, both power output and the fatigue profile are underestimated by an amount dependent on resistive load. In cases where inertia correction is not possible during a repeated sprints test, a heavy load may be preferable.

Seven 6 s sprints with 30 s recovery between sprints were performed against two resistive loads: 50 (L50) and 100 (L100) g · kg-1 body mass. Inertia-corrected and -uncorrected peak and mean power output were calculated. Corrected peak power output in corresponding sprints and the drop in peak power output relative to sprint 1 were not different in the two conditions, despite the fact that mean power output was 15-20% higher in L100 (P < 0.01). The effect of inertia correction on power output was more pronounced for the lighter load (L50), with uncorrected peak power output in sprint 1 being 42% lower than the corresponding corrected peak power output, while this was only 16% in L100. Fatigue assessed by the drop in uncorrected peak and mean power output in sprint 7 relative to sprint 1 was less compared with that obtained by corrected power values, especially in L50 (drop in uncorrected vs. corrected peak power output: 13.3 ± 2.2% vs. 23.1 ± 4.1%, P < 0.01). However, in L100, the difference between the drop in corrected and uncorrected mean power output in sprint 7 was much smaller (24.2 ± 3.1% and 21.2 ± 2.7%, P < 0.01), indicating that fatigue may be safely assessed even without inertia correction when a heavy load is used. In conclusion, when inertia correction is performed, fatigue during repeated sprints is unaffected by resistive load. When inertia correction is omitted, both power output and the fatigue profile are underestimated by an amount dependent on resistive load. In cases where inertia correction is not possible during a repeated sprints test, a heavy load may be preferable.

Seven 6 s sprints with 30 s recovery between sprints were performed against two resistive loads: 50 (L50) and 100 (L100) g · kg-1 body mass. Inertia-corrected and -uncorrected peak and mean power output were calculated. Corrected peak power output in corresponding sprints and the drop in peak power output relative to sprint 1 were not different in the two conditions, despite the fact that mean power output was 15-20% higher in L100 (P < 0.01). The effect of inertia correction on power output was more pronounced for the lighter load (L50), with uncorrected peak power output in sprint 1 being 42% lower than the corresponding corrected peak power output, while this was only 16% in L100. Fatigue assessed by the drop in uncorrected peak and mean power output in sprint 7 relative to sprint 1 was less compared with that obtained by corrected power values, especially in L50 (drop in uncorrected vs. corrected peak power output: 13.3 ± 2.2% vs. 23.1 ± 4.1%, P < 0.01). However, in L100, the difference between the drop in corrected and uncorrected mean power output in sprint 7 was much smaller (24.2 ± 3.1% and 21.2 ± 2.7%, P < 0.01), indicating that fatigue may be safely assessed even without inertia correction when a heavy load is used. In conclusion, when inertia correction is performed, fatigue during repeated sprints is unaffected by resistive load. When inertia correction is omitted, both power output and the fatigue profile are underestimated by an amount dependent on resistive load. In cases where inertia correction is not possible during a repeated sprints test, a heavy load may be preferable.

OBJECTIVES: To estimate incremental effects of patients' dependence and function on costs of care during the early stages of Alzheimer's disease (AD) and to compare strengths of their relationships with different cost components. DESIGN: Multicenter, cross-sectional, observational study. SETTING: Three university hospitals in the United States. PARTICIPANTS: One hundred seventy-nine community-living patients with probable AD, with modified Mini-Mental State Examination scores of 30 or higher. MEASUREMENTS: Patients' dependence was measured using the Dependence Scale (DS). Functional capacity was measured using the Blessed Dementia Rating Scale (BDRS). Total cost was measured by summing direct medical costs and informal costs. Direct medical costs included costs of hospitalization, outpatient treatment and procedures, assistive devices, and medications. Informal costs were estimated from time spent helping with basic and instrumental activities of daily living for up to three caregivers per patient using national average hourly earnings as wage rate. RESULTS: DS and BDRS were associated with higher total cost; a 1-point increase in DS was associated with a $1,832 increase in total cost, and a 1-point increase in BDRS was associated with a $3,333 increase. Examining component costs separately identified potential differences between DS and BDRS. A 1-point increase in BDRS was associated with a $1,406 increase in direct medical cost. A 1-point increase in DS was associated with a $1,690 increase in informal cost. CONCLUSION: Patients' dependence and function related differently to direct medical and informal cost, suggesting that measures of function and dependence provided unique information for explaining variations in cost of care for patients with AD, highlighting the value in measuring both constructs.

We examined effects of the task of categorizing linear frequency-modulated (FM) sweeps into rising and falling on auditory evoked magnetic fields (AEFs) from the human auditory cortex, recorded by means of whole-head magnetoencephalography. AEFs in this task condition were compared with those in a passive condition where subjects had been asked to just passively listen to the same stimulus material. We found that the M100-peak latency was significantly shorter for the task condition than for the passive condition in the left but not in the right hemisphere. Furthermore, the M100-peak latency was significantly shorter in the right than in the left hemisphere for the passive and the task conditions. In contrast, the M100-peak amplitude did not differ significantly between conditions, nor between hemispheres. We also analyzed the activation strength derived from the integral of the absolute magnetic field over constant time windows between stimulus onset and 260 ms. We isolated an early, narrow time range between about 60 ms and 80 ms that showed larger values in the task condition, most prominently in the right hemisphere. These results add to other imaging and lesion studies which suggest a specific role of the right auditory cortex in identifying FM sweep direction and thus in categorizing FM sweeps into rising and falling.

We study theoretically the potential for control of the electron population in a single GaAs/AlGaAs quantum well that is coupled by strong pulsed electromagnetic fields. Using numerical calculations we present the conditions that lead to high-efficiency intersubband population inversion.

Kamberidou, I. (2008). ‘Eliminating the Leaky Pipeline: Sustaining-Normalizing-Engendering Women's Careers as Academics, Researchers and Professionals in Engineering, Computers and the Sciences’. Presentation at the UNICAFE Dissemination Conference "Beyond the Glass Ceiling: Women Academics in Engineering, Technology and Life Sciences across Europe", November 12-13, 2008, venue: Istanbul Technical University, Faculty of Architecture. Sixth Research Framework Programme of the European Union SAS6-CT-2006-036695 (http://www.womenacademics2008org). ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- My presentation discusses the obstacles that female students face as they attempt to access higher education and achieve success and propose an action plan. Such an action plan requires  Innovative strategies that facilitate academic achievement;  teacher-training to learn innovative, practical and successful  strategies that can be implemented at their institutions  that will enable them to help women students  overcome obstacles on their  path towards a college degree; promoting institutional policies that support retention efforts; financial aid; developing corporate and community partnership; creating a campus atmosphere that promotes engagement and success, among other things  Focusing on the factors that contribute to Greek women’s non-engagement and under-representation in engineering and technology, and in particular the technological gender gap or digital divide in the knowledge economy, this presentation will examine the ‘gendered’ educational institutions in Greece while providing an overview of the gender distribution in the Greek academia.  Undeniably, the overall participation of women in engineering, science and technology is low. Women still comprise a minority in the Greek academia, and especially in the higher academic hierarchies. The ‘genderedness’ of educational institutions in Greece, traditional perspectives, the glass ceiling, the leaky pipeline, the life/work balance or rather imbalance, the lack of affordable child care facilities, among other things, have contributed to the declining interest of women for engineering and technology study programs. Irrefutably education is the place to start, given that socially inclusive educational systems and equity policies are key variables to responding to global change, however it is not enough. Promoting new pedagogical applications as well as recruiting or recognizing the largely untapped pool of talent  What is vital is retention. Retaining, women in their careers in engineering, in science and technology, and in R&D, in addition to increasing their participation in leadership— from decision-making to execution phases— in the light of demographic pressures, aging populations and the low levels of immigration tolerance around Europe. Retention requires the establishment of nurturing inclusive workplace cultures, supportive and socially inclusive working environments, the application of best practices, sustainable diversity efforts and ‘sensitivity’ training to raise awareness. Enhancing conditions for research and innovation in Europe calls for inclusive organizational cultures that allow women to function at their full potential for the benefit of their organization/institution, thereby reproducing female participation.    

Objective: To quantify the amount of Total Volatile Organic Compounds (TVOCs) emitted from five dental substances commonly used in a dental clinic. Method: An assessment of the indoor air quality in two clinics of the Athens University Dentistry Faculty was conducted. Results: It was found that TVOC emissions from Kalocryl and Bacillol reached extremely high values affecting the air in the dental clinics at short and long distances from the source. Six pollutants TVOCs, CO2, PM10, PM25, SO 2 and NOx were measured and indoor sources associated with dental activities were identified. Very high concentrations of TVOCs were found which exceeded the acceptable levels by a factor of 20, associated with the nature of the dental activities and the ventilation conditions. The CO 2 concentration levels were high and the indoor conditions were considered unsatisfactory, associated with the number of occupants and the ventilation conditions. PM concentrations were high due to the nature of the dental activities and they exceeded the outdoor levels by a factor of 5 to 6. The concentrations of the gaseous pollutants NOx were low while the SO 2 concentrations were hardly detectable. © 2008 FDI/World Dental Press.

Καμπερίδου, Ε. (2008). Κοινωνικό Φύλο, Φυσική Αγωγή και Αθλητισμός. Πανεπιστημιακές Σημειώσεις του μαθήματος επιλογής «Κοινωνικό Φύλο και Αθλητισμός» του ΤΕΦΑΑ. Εθνικό & Καποδιστριακό Πανεπιστήμιο Αθηνών- Εκδόσεις ON DEMAND A.E.ΔΕΙΓΜΑ/SAMPLE ATTACHED----------------------------------------------------------- Καμπερίδου, Ειρήνη. (2008). Κοινωνικό Φύλο, Φυσική Αγωγή και Αθλητισμός [Gender, Physical Education and Sport] (102 σελίδες). Πανεπιστημιακές Σημειώσεις για μάθημα επιλογής ΚΟΙΝΩΝΙΚΟ ΦΥΛΟ & ΑΘΛΗΤΙΣΜΟΣ, Αθήνα: Εθνικό & Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Εκδόσεις ON DEMAND A.E.Abstract fylofysikiagogikaiathlitismos2008.compressed.pdf  

Optically Stimulated Luminescence (OSL) dating techniques are extensivelly used in nowadays to provide chronological information of sediment material (Zacharias et al., in press) related to landscape evolution caused by natural phenomena or influenced by human activities. Within the present study, OSL was employed to provide the age profile of sand dune formations from Mainland Greece (Peloponnese) and the islands of Crete and Corfu. The application of OSL dating was practised on quartz samples extracted from the sedimentmaterial using a modified SAR protocol (Murray and Wintle 2000). The estimation of samples dosimetry was based on gamma- (Tzortzis and Tsertos, 2004) and alpha-spectrometry (Michael and Zacharias, 2000) to provide the U, Th and K concentrations. The so far dating results indicate for ages that fall within Late Holocene to modern periods (4,000 - 500 years). The study will report on the geomorphological, micromorphological and dating results in anattempt to form the environmental and chronological framework of the dune formations in Greece.

The past 2 decades have brought worrying increases in severe Streptococcus pyogenes diseases globally. To investigate and compare the epidemiological patterns of these diseases within Europe, data were collected through a European Union FP-5-funded program (Strep-EURO). Prospective population-based surveillance of severe S. pyogenes infection diagnosed during 2003 and 2004 was undertaken in 11 countries across Europe (Cyprus, the Czech Republic, Denmark, Finland, France, Germany, Greece, Italy, Romania, Sweden, and the United Kingdom) using a standardized case definition. A total of 5,522 cases were identified across the 11 countries during this period. Rates of reported infection varied, reaching 3/100,000 population in the northern European countries. Seasonal patterns of infection showed remarkable congruence between countries. The risk of infection was highest among the elderly, and rates were higher in males than in females in most countries. Skin lesions/wounds were the most common predisposing factor, reported in 25% of cases; 21% had no predisposing factors reported. Skin and soft tissue were the most common foci of infection, with 32% of patients having cellulitis and 8% necrotizing fasciitis. The overall 7-day case fatality rate was 19%; it was 44% among patients who developed streptococcal toxic shock syndrome. The findings from Strep-EURO confirm a high incidence of severe S. pyogenes disease in Europe. Furthermore, these results have identified targets for public health intervention, as well as raising awareness of severe S. pyogenes disease across Europe.

The geochemical characteristics of topsoil depend on many variables such as thelithological nature of the geological environment, climatic conditions and humaneffects. This paper focuses οn assessing the contribution of lithology to soilgeochemistry, through the process of erosion. For this purpose, extensive field workwas carried out, including lithologic recognition of formations, rock and soil samplingand finally definition of possible human impacts that affect the chemical status ofsoils. Supplementary information was adopted from the pre-existing literature for thearea, as well as from geomorphological characteristics, climatic conditions andchemical analyses of both rock and soil. Thus, a primary database has beendeveloped, in order to asses the correlation between susceptibility of outcroppinggeological formations and soil geochemical status. The area of Kopaida basin, incentral Greece, was chosen as a case study, and the final outcome was the developingof an erosion risk map for the prevailing geological formations, which may be used asuseful tool for developing appropriate strategies on environmental protection, hazardassessment and regional planning.

This paper describes the evaluation of a service-oriented prototype implementation. The prototype development aims to exploit the use of service-oriented concepts for achieving healthcare interoperability while it also attempts to move towards a virtual patient record paradigm. The proposed evaluation strategy investigates the adaptation of the DeLone and McLean model of information systems success with respect to service-oriented implementations. Specific service-oriented and virtual patient record characteristics were empirically encapsulated in the DeLone and McLean model and respective evaluation measures were produced. The proposed theoretical framework was utilized for conducting an empirical study amongst sixty two participants in order to observe their perceptions with respect to the hypothetical adoption of the prototype framework. The data gathered was analyzed using partial least squares. The generated results highlighted the importance of information quality whereas system quality did not prove to be a strong significant predictor in the overall model.

INTRODUCTION: It seems that there is a trend in undergraduate medical education towards including clinical attachments in primary health care (PHC) worldwide. The benefits of such initiatives are already well described. The aim of this study was to evaluate the effect of a clinical attachment in undergraduate medical students in a European country with an odd medical educational system that essentially lacks any kind of academic PHC departments. METHODS: The study was undertaken during 2005-2007. A non-mandatory 1-week clinical attachment in PHC/general practice was organized in an urban PHC unit by general practitioners with educational experience in collaboration with the Department of Physiology of the local medical school. The participants were a prospective cohort of medical students in the 2nd year of undergraduate studies. All participating students sat a pre-defined clinical exam which consisted of multiple choice questions, mini case papers and an objective-structured clinical examination before and after the attachment. In addition, the students rated the whole process. RESULTS: The response ratio was 77.06%. The mean score on objective structured clinical examination of participants increased from 30.70/100 to 62.28/100 (p < 0.001). The students' impression of the study was rather positive (4.39/5). DISCUSSION: The educational intervention of including a clinical attachment in an undergraduate curriculum seems to have encouraging results, considering the peculiarity of inexistence of academic departments of PHC or General Practice in the national medical schools and the inexperience of students regarding similar concepts.

The aim of the study was to evaluate the prognostic ability of the transcriptional profiling of the HER family genes in early breast cancer, as well as to investigate the predictive value of HER2 mRNA expression for adjuvant treatment with paclitaxel. RNA was extracted from 268 formalin-fixed paraffin-embedded (FFPE) tumour tissue samples of high-risk breast cancer patients enrolled in the randomised HE10/97 trial, evaluating the effect of dose-dense anthracycline-based sequential adjuvant chemotherapy with or without paclitaxel. The mRNA expression of all four HER family members was assessed by kinetic reverse transcription-polymerase chain reaction (kRT-PCR). The overall concordance between kRT-PCR and IHC/FISH for HER2 status determination was 74%. At a median follow-up of 8 years, multivariate analysis showed that EGFR and HER2 mRNA expression was associated with reduced overall survival (OS). HER3 and HER4 mRNA level had a favourable prognostic value in terms of OS and disease-free survival (DFS), respectively. Adjusting for HER2 mRNA expression, OS and DFS did not differ between treatment groups. These data indicate that EGFR as well as HER2 are prognostic factors of worse clinical outcomes, whereas HER3 and HER4 gene transcription is associated with better prognosis in high-risk early breast cancer. However, HER2 mRNA expression did not predict clinical benefit from paclitaxel. Kinetic RT-PCR represents an alternative method for evaluating the expression of HER family members in FFPE breast carcinomas. © 2008 Cancer Research.

The South Balkan extensional system consists of normal faults and associated sedimentary basins within southern Bulgaria, Macedonia, eastern Albania, northern Greece, and northwestern Turkey. Extensional tectonism began during the final convergence across the Vardar, Intra-Pontide, and Izmir-Ankara suture zones, where oceanic regions closed between continental Europe and continental fragments that make up the Pelagonian, Sakar, and western Anatolian tectonic units. Earliest extension of latest Cretaceous- middle Eocene age appears to have occurred within a regional convergent tectonic setting and may be related to an increase in gravitation potential energy within a thickening continental lithosphere. Following diachronous closure across the suture zone, from the middle Eocene to late Oligocene, the transition from a regionally convergent to a regionally extensional tectonic setting occurred and was associated with abundant magmatism and formation of sedimentary basins. Extension was associated with lithospheric thinning probably related to changes in geometry of the subducted slab, dynamics of the mantle wedge, and beginning of slab rollback along the Hellenic subduction zone. A short period of local and diachronous (?) shortening (during latest Oligocene-early Miocene time) occurred in the Thrace basin of northwestern Turkey and in some basins in western Bulgaria and eastern Macedonia. Regional extension began in middle Miocene time and was related to the regional extensional tectonic setting that has dominated the Aegean extensional region to the present. Trench rollback was the dominant dynamic process, but during late Miocene time it was modified by the formation of the western part of the North Anatolian fault zone that partially decoupled the South Balkan extensional system from the Aegean extensional region. During late Cenozoic time, east-west-striking normal faults and associated sedimentary basins in the eastern part of the South Balkan extensional system propagated westward in tandem with westward migration of north-south-striking normal faults and sedimentary basins from western Bulgaria into eastern Albania. This migration was caused by evolution of the Hellenic subduction zone as it increased its curvature during trench rollback and clockwise and counterclockwise rotation of crustal fragments in the west and east, respectively. After formation of the western part of the North Anatolian fault zone, extension within the eastern part of the South Balkan extensional system was related to southward movement of its lithosphere at a slower rate than the extension within the Aegean extensional region. Active extension and basin formation show two provinces of extension that are nearly at right angles to one another and their overlap in the central South Balkan extensional system: east-west extension in central Albania to eastern Macedonia and north-south extension from northwestern Greece and eastern Macedonia to eastern Bulgaria and northwestern Turkey.

An alternative to TRO model of a W UMa-type star is presented in which the binary is past mass exchange with mass ratio reversal. The secondary is hydrogen depleted and both components are in thermal equilibrium. Evolution in contact is driven by orbital angular momentum loss and mass transfer from the secondary to primary component, similarly as it is observed in Algols. Temperature equalization of both components results from an assumed energy transfer by a large scale flow encircling the whole system in the common envelope.

Although platinum-based chemotherapy remains the "standard" in advanced non small-cell lung cancer, not all patients-derive clinical benefit from such a treatment. Hence, the development of predictive biomarkers able to identify lung cancer patients who are most likely to benefit from cisplatin-based chemotherapy has become a scientific priority. Among the molecular pathways involved in DNA damage control after chemotherapy, the nucleotide excision repair (NER) is a critical process for the repair of DNA damage caused by cisplatin-induced DNA adducts. Many reports have explored the role of the excision repair cross-complementation group 1 enzyme (ERCC1) expression in the repair mechanism of cisplatin-induced DNA adducts in cancer cells. Using immunohistochemistry in resected tumors from patients included in the International Adjuvant Lung Cancer Trial, the study of important biomarkers showed that high ERCC1 protein expression was associated with improved survival in chemo-naïve patients. On the contrary, the benefit of adjuvant cisplatin-based chemotherapy was more profound in patients with low ERCC1 expression. In a prospective cohort studying mRNA expression in tumor biopsies from patients receiving customized therapy with cisplatin and gemcitabine depending on the molecular profile of the tumour, results showed that patients with low ERCC1 mRNA expression had a longer median survival compared to those with high expression. These data suggest the potent use of ERCC1 as a molecular predictor of clinical resistance to platinum-based chemotherapy in the adjuvant setting of NSCLC. Nevertheless, optimization of methodology, including standardization of technical procedures, as well as validation of ERCC1 protein expression in large prospective cohorts, seem necessary before any routine immunohistochemical validation of ERCC1 can be implemented in daily practice.

Exercise-induced (EI) hypersensitivity disorders are significant problems for both recreational and competitive athletes. These include EI-asthma, EI-bronchoconstriction, EI-rhinitis, EI-anaphylaxis and EI-urticaria. A group of experts from the European Academy of Allergology and Clinical Immunology and the American Academy of Allergy Asthma and Immunology met to discuss the pathogenesis of these disorders and how to diagnose and treat them, and then to develop a consensus report. Key words (exercise with asthma, bronchoconstriction, rhinitis, urticaria or anaphylaxis) were used to search Medline, the Cochrane database and related websites through February 2008 to obtain pertinent information which, along with personal reference databases and institutional experience with these disorders, were used to develop this report. The goal is to provide physicians with guidance in the diagnosis, understanding and management of EI-hypersensitivity disorders to enable their patients to safely return to exercise-related activities.

An alternative route for the synthesis of a photoaffinity labelling (PAL) dCTP derivative is reported. This method involves the intermediacy of exo-N-[2-(4-azido-2,3,5,6-tetrafluorobenzamido)ethyl]-dC. The latter is prepared from the coupling of known N-(2-aminoethyl)-4-azido-2,3,5,6-tetrafluorobenzamide, prepared in an improved three-step sequence, with an activated 4-triazolyl derivative of dU, followed by deprotection. 19F NMR spectroscopy proved extremely useful in following the synthetic transformations, and enabled control of any adventitious reduction of the azides. © 2007 Elsevier Ltd. All rights reserved.

Air quality in two large athletic halls with different ventilation (natural and mechanical) was investigated in relation to outdoor pollution and meteorological conditions. Simultaneous measurements of O3, NO, NO2 and SO2 were performed in the halls at two heights (at the arena and spectators’ seats) and outdoors. BTX concentrations at the spectators’ seats and outdoor NMHCs, CH4, PM10 and CO concentrations were also measured. Analysis of diurnal variations of the pollutants’ concentrations, cross correlation analysis of the concentration time-series and principal component analysis were applied to the collected data. Results revealed that outdoor pollution significantly affected indoor air quality of both halls. However, this effect was different for the two buildings, depending on the ventilation types, the wind direction prevailing at the areas and the kind of indoor activity recorded. It was found that the latter parameters controlled the pollutants concentration levels in the halls and their response to the changes of the outdoor pollution levels. Temperature and pollution stratification enhancing during athletic events were also evident in both halls but with different characteristics observed, such as the spatial distribution of the indoor pollutants. The airflow patterns prevailing in each hall, imposed by the ventilation operation schemes were important factors. © 2007 Elsevier Ltd. All rights reserved.

BACKGROUND: L-Dopa decarboxylase (DDC) is a pyridoxal 5'-phosphate-dependent enzyme that was found to be involved in many malignancies. The aim of this study was to investigate the mRNA expression levels of DDC in prostate tissues and to evaluate its clinical utility in prostate cancer (CaP). METHODS: Total RNA was isolated from 118 tissue specimens from benign prostate hyperplasia (BPH) and CaP patients and a highly sensitive quantitative real-time RT-PCR (qRT-PCR) method for DDC mRNA quantification has been developed using the SYBR Green chemistry. LNCaP prostate cancer cell line was used as a calibrator and GAPDH as a housekeeping gene. RESULTS: DDC was found to be overexpressed, at the mRNA level, in the specimens from prostate cancer patients, in comparison to those from benign prostate hyperplasia patients (p<0.001). Logistic regression and ROC analysis have demonstrated that the DDC expression has significant discriminatory value between CaP and BPH (p<0.001). DDC expression status was compared with other established prognostic factors, in prostate cancer. High expression levels of DDC were found more frequently in high Gleason's score tumors (p=0.022) as well as in advanced stage patients (p=0.032). CONCLUSIONS: Our data reveal the potential of DDC expression, at the mRNA level, as a novel biomarker in prostate cancer.

 Recent studies argue that the spread-adjusted Taylor rule (STR), which includes a response to the credit spread, replicates monetary policy in the United State. We show (1) STR is a theoretically optimal monetary policy under heterogeneous loan interest rate contracts in both discretionay and commitment monetary policies, (2) however, the optimal response to the credit spread is ambiguous given the financial market structure in theoretically derived STR, and (3) there, a commitment policy is effective in narrowing the credit spread when the central bank hits the zero lower bound constraint of the policy rate.

Women are more likely than men to suffer from stress-related mental disorders, such as depression. In the present experiments, we identified sex differences in one of the most common animal models of depression, that of learned helplessness. Male and female rats were trained to escape a mild footshock each day for 7 days (controllable stress). Each rat was yoked to another rat that could not escape (uncontrollable stress), but was exposed to the same amount of shock. One day later, all stressed rats and unstressed controls were tested on a more difficult escape task in a different context. Most males exposed to uncontrollable stress did not learn to escape and were therefore helpless. In contrast, most females did learn to escape on the more difficult escape task, irrespective of whether they had been exposed to controllable or uncontrollable stress. The sex differences in helplessness behavior were not dependent on the presence of sex hormones in adulthood, because neither ovariectomy of females nor castration of males abolished them. The absence of helplessness in females was neither dependent on organizational effects of testosterone during the day of birth, because masculinized females did not express helplessness as adults. Thus, sex differences in helplessness behavior are independent of gonadal hormones in adulthood and testosterone exposure during perinatal development. Learned helplessness may not constitute a valid model for depressive behavior in women, at least as reflected by the response of female rats to operant conditioning procedures after stressful experience.

The purpose of this study was to investigate the relationship between skeletal muscle fiber type composition and the maximum number of repetitions performed during submaximal resistance exercise. Twelve young men performed a maximum repetitions test at 85% of 1 repetition maximum (1RM) in the leg press, which was repeated after 1 week. Seven days after the second 85% 1RM test, they performed a maximum repetitions test at 70% of 1RM in the leg press. This test, at 70% 1RM, was repeated 7 days later. One week before the initiation of the testing sessions, a biopsy sample was obtained from the vastus lateralis muscle and analyzed for fiber type distribution, fiber cross-sectional area, and capillary density (capillaries x mm(2)). A low and nonsignificant relationship was found between the fiber type distribution or percent fiber type area and the number of repetitions performed at either 70% or 85% 1RM. Moreover, the number of repetitions performed at 70% or 85% of 1RM was not related significantly with 1RM strength. In contrast, the number of repetitions performed at 70% 1RM was significantly correlated with the number of capillaries per mm(2) of muscle cross-sectional area (r = 0.70; p = 0.01). These results suggest that fiber type composition is not the major biological variable regulating the number of repetitions performed in submaximal resistance exercise. Rather, it seems that submaximal strength performance depends on muscle capillary density, which is linked with the endurance capacity of the muscle tissue.

Rhodium and iridium complexes of flexible scorpionate ligands based on azaindole were synthesised in good yields. The complexes were characterised in solution and in the solid state. Structural characterisation revealed a B-H-metal interaction, which is retained in solution. Given the greater flexibility of the ligand and potential cooperative effect of boron, the complexes were tested for their activity in the transfer hydrogenation of ketones. © 2008 The Royal Society of Chemistry.

Stars with changing Blazhko periods challenge the currently proposed hypotheses for the Blazhko effect. RR Lyr, the prototype of the class, is one of the best-studied Blazhko stars but it keeps on surprising its observers. We present the first results from a photometric follow- up campaign in 2006-2007 of the star. Multicolour data were gathered from 4 different observatories in the northern hemisphere. Our analysis focuses specifically on the period behaviour. We confirm the previously reported decrease of the modulation period.

Patients with lower limb and pelvic trauma, or undergoing major orthopaedic surgery represent one of the highest risk groups for the development of venous thromboembolism (VTE). A significant number of pharmacological and mechanical agents have been used for the prophylaxis and treatment of VTE. Fondaparinux is a relative new pharmacological agent that selectively binds to antithrombin, and represents a new class of synthetic selective inhibitors of activated factor X. Eleven percent of the fondaparinux-related English language literature, between 2001 and 2007, refers to orthopaedic trauma, and was the sample assessed for this critical analysis review. The clinical studies evaluating the safety, efficacy, and financial implications associated with lower limb orthopaedic trauma show that fondaparinux has comparable results with the well-established use of enoxaparin. However, the scientific community has raised several issues regarding mostly fondaparinux's safety, timing of its 1(st) dose, bleeding side effects, duration of administration and lack of a reliable reversing agent. Further trials are necessary focusing on the safety and efficacy of this drug mostly in relation to clinical relevant outcomes and to different fields of trauma surgery (pelvis, long bone fractures and polytrauma patients).

The purpose of the present studies was twofold: (a) to describe the spectrum of goals adopted in physical education, and, (b) to relate forced-choice reports of goal orientations to open-ended, qualitative ones. Elementary (n = 139) and middle school (n = 342) physical education students participated in two studies. Results indicated that mastery approach goals included strong elements of social goals, (b) mastery avoidance goals were nonexistent, questioning their presence in physical education, (c) performance approach goals involved strong elements of mastery approach goals and social goals, and, (d) performance avoidance goals involved high frequencies of mastery goals and affectivity goals. Also, the relationship between students' forced selection of goal orientations and their responses to open-ended questions was rather low. It is concluded that multiple goals are most likely operative in achievement contexts and researchers may need to focus on their combination in order to understand students' achievement strivings.

To capture patterns of normal age-associated atrophy, we previously used a multivariate statistical approach applied to voxel based morphometry that identified age-associated gray and white matter covariance networks (Brickman et al. [2007]: Neurobiol Aging 28:284-295). The current study sought to examine the stability of these patterns by forward applying the identified networks to an independent sample of neurologically healthy younger and older adults. Forty-two younger and 35 older adults were imaged with standard high-resolution structural magnetic resonance imaging. Individual images were spatially normalized and segmented into gray and white matter. Covariance patterns that were previously identified with scaled subprofile model analyses were prospectively applied to the current sample to identify to what degree the age-associated patterns were manifested. Older individuals were also assessed with a modified version of the Mini Mental State Examination (mMMSE). Gray matter covariance pattern expression discriminated between younger and older participants with high optimal sensitivity (100%) and specificity (90.5%). While the two groups differed in the degree of white matter pattern expression (t (75) = 5.26, P < 0.001), classification based on white matter expression was relatively low (sensitivity = 80% and specificity = 61.9%). Among older adults, chronological age was significantly associated with increased gray matter pattern expression (r (32) = 0.591, P < 0.001) but not with performance on the mMMSE (r (31) = -0.314, P = 0.085). However, gray matter pattern expression was significantly associated with performance on the mMMSE (r (31) = -0.405, P = 0.024). The findings suggest that the previously derived age-associated covariance pattern for gray matter is reliable and may provide information that is more functionally meaningful than chronological age.

SUMMARY: Fracture healing constitutes a complex and delicate physiological process. Local vascularity at the site of the fracture has been identified as one of the most significant parameters influencing the healing procedure. VEGF is the most important component of the regeneration of the vascular system at the fracture site. The aim of this review is to determine the evidence supporting the direct role of VEGF in the enhancement of fracture healing and the possible clinical use of VEGF for non-unions. The literature search was performed via the internet using the Medline. The key words which were searched in the abstracts were the terms "VEGF", "angiogenesis", "fracture", "bone" and "healing". Twenty-five articles were relevant to the topic of interest. A total of 11 articles were excluded from our research due to non conformity of their content to the inclusion criteria. Evidence retrieved suggests that VEGF could be extremely valuable for the treatment of critical size bone defects and that VEGF could have a direct effect on osteoprogenitor cells, mainly by promoting the differentiation of osteoblasts and by increasing the mineralisation of the regenerated bone. The former observation could have very interesting repercussions for the field of non-unions and the latter for the field of osteoporosis.

The aim of this study is to estimate future potential changes in duration of extreme dry and wet spells and rainfall intensity in Eastern Mediterranean. For this purpose, daily precipitation amounts, deriving from the regional climate model of UK Hadley Centre HadRM3P have been used for the present (1960-1990) and the future period 2070-2100 on 0.44° × 0.44° latitude by longitude grid. Future data are based on B2 IPCC emission scenario. For the identification of precipitation extremes three climatic indices were employed: a) CWD (Maximum number of consecutive wet days), b) CDD (Maximum number of consecutive dry days) and c) SDII (quotient of precipitation amount of wet days and the number of wet days of the period). They were calculated for the present and future period, on a seasonal and annual basis. A general future tendency was found towards drier Eastern Mediterranean, with reduced rainfall intensity. Longer dry spells are expected in all seasons, except autumn, with the largest increase in the southern part of the area. Extreme wet spells will shorten everywhere during all seasons, except autumn. Precipitation intensity was found reduced for all seasons and mostly for summer in South Aegean Sea. © 2008 Global NEST Printed in Greece. All rights reserved.

FYLOPAEDIA («Φύλο και Αθλητισμός») στον «κατάλογο με τις περισσότερες αναφορές»  “Αυτή η σελίδα έχει προσπελαστεί 2.229 φορές” (τελευταία πρόσβαση 24/9/2014  Αφορά το λήμμα: Καμπερίδου, Ειρήνη (2008). «Φύλο και Αθλητισμός». FYLOPAEDIA-Φύλο Παιδεία. Ηλεκτρονικό Εγκυκλοπαιδικό Λεξικό του Προγράμματος ΘΕ.ΦΥΛ.ΙΣ., Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών. (www.thefylis.uoa.gr/fylopedia)  http://www.fylopedia.uoa.gr/index.php?title=%CE%9A%CE%B1%CF%84%CE%B7%CE%B3%CE%BF%CF%81%CE%AF%CE%B1:%CE%9B%CE%AE%CE%BC%CE%BC%CE%B1%CF%84%CE%B1

Erosion represents a natural process, during which particles of geologicalformations are carried away by water, wind or by their combination. It is asignificant social and economic problem, which makes research on land and watermanagement necessary. Monitoring of erosion is needed in order to predict thedevelopment of the incident and moderate it.The selected study area is the Syros Island, a small Cycladic island. In order toassess erosion risk index, a number of effective factors were used. These factorswere used as input variables of the risk model, from which derived the outputvariable that lead to the production of the erosion risk map.

The increasing worldwide apprehension of groundwater contamination problems generated the concept of groundwater vulnerability, which is based on the theory that the natural environment can offer some degree of protection to groundwater, against the natural and human impacts,especially considering, contaminants entering the subsurface environment. Although there are several methods related to the vulnerability risk assessment and mapping for porous and karstic media, there is no relative method concerning the discontinuous media. Studying groundwatervulnerability on the smaller islands of the Aegean Sea is important, because water supplies are few and avoiding contaminants entering the groundwater is vital. Tinos Island has significant water tables, as far as quantity and quality is concerned. The selected study area is theFalatados-Livada drainage system, which is developed along the lithological contact of granites and schists. In order to assess groundwater intrinsic vulnerability, a number of effective factors were used. These factors were used as input variables of the risk model, from which derived theoutput variable that lead to the production of the groundwater intrinsic vulnerability risk map.

Background: Giant cell arteritis (GCA) of the breast is one of the less recognized variants of this vasculitis and may represent an isolated finding or a manifestation of a more widespread disease. Case Report: We present the case of a 74-year-old woman with malaise and a 14-day persistent fever, reaching 38°C. There was a bilateral, painless and mobile axillary lymphadenopathy and a slight tenderness over the medial and lateral upper quadrants of her left breast, as well as an independent palpable tender mass in the upper outer quadrant of the same breast measuring 2 cm in its greatest diameter. Constitutional symptoms, anemia and an elevated erythrocyte sedimentation rate suggestive of polymyalgia rheumatica were also present. An invasive ductal carcinoma of the breast with coincidental pathologic findings of GCA in the same biopsy specimen was revealed. In this case, arteritis was limited to the breast and presented with diffuse breast tenderness. No other artery was involved by GCA. All arteritis-related symptoms disappeared after the removal of the tumor. Conclusions: There is a relationship between cancer, particularly breast cancer, and GCA of the same organ, but the real nature of this association still remains unknown. Copyright © 2008 S. Karger AG.

In this paper, we review the basic morphosyntactic and phonological properties of object clitic pro- nouns in Standard Greek. More specifically, we discuss the constraints on the combinatorial properties of clitic clusters and present evidence in support of the out-of-cycle adjunct status of clitic-doubled DP-objects. We then account for the distribution of object clitics with respect to the verb by means of a cliticization movement rule. Finally, we show that there is an asymmetry in the way object clitics are prosodically organized, depending on their position in relation to the verb. Being always a part of the phonological word of their verbal host, enclitics choose to incorporate to it whereas proclitics opt for prosodic adjunction.

Using Chandra, XMM and optical data (both photometric and spectroscopic), we studied the X-ray binary population in the Small Magellanic Cloud (SMC), down to an X-ray luminosity of ~4×10^33 erg s-1, thus allowing the investigation of the faintest of the high-mass Xraybinary populations. The regions were selected so as to have varying star formation histories, in order to investigate, using homogeneous and well defined samples, the connection between the Be- XRB phenomenon and SF history. The characterization of the X-ray sources discovered in our Chandra and XMM surveys and the selection of our sample of Be-XRBs, was based on a combination of X-ray and optical properties. We found that the number of Be/X-ray binaries (Be-XRBs) peaks at the age of 40-70 Myr ago. Finally, we constructed their X-ray luminosity function (XLF). There are very few X-ray sources above ~10^35 ergs^-1, which is consistent with the transient nature of Be X-ray binaries. There is also indication for a flattening of the XLF at ~10^35 ergs^-1, which would be consistent with the onset of the propeller effect.

The role of high-dose chemotherapy (HDCT) in epithelial ovarian cancer (EOC) remains controversial. This study was initiated to compare the efficacy and tolerability of HDCT as a consolidation approach in women with chemosensitive advanced EOC (FIGO stages IIC-IV). Patients who had achieved their first clinical complete remission after six cycles of conventional paclitaxel and carboplatin combination chemotherapy were randomly assigned to receive or not high-dose melphalan. The primary objective was to compare time to disease progression (TTP). A total of 80 patients were enrolled onto the trial. Patients who were randomized to receive HDCT were initially treated with cyclophosphamide 4g/m2 for PBPC mobilization. HDCT consisted of melphalan 200 mg/m2. Of the 37 patients who were allocated to HDCT, 11 (29.7%) did not receive melphalan either due to patient refusal (n = 5) or due to failure of PBPC mobilization (n = 6). In an intent-to-treat analysis, there were no significant differences between the two arms in TTP (P = 0.059) as well as in overall survival (OS) (P = 0.38).

OBJECTIVES: To (1) compare home health and informal (unpaid) services utilization among patients with Alzheimer's disease (AD), (2) examine longitudinal changes in services use, and (3) estimate possible interdependence of home health and informal care utilization. METHODS: The sample is drawn from the Predictors Study, a large, multicenter cohort of patients with probable AD, prospectively followed annually for up to 7 years in three university-based AD centers. Bivariate probit models estimated the effects of patient characteristics on home health and informal care utilization. RESULTS: A large majority of the patients (80.6%) received informal care with a smaller proportion (18.6%) receiving home health services. Home health services utilization increased from 9.9% at baseline to 34.5% in year 4. Among users, number of days that services were provided in three-month recall increased from 21.9 to 56 days over time. Home health services utilization was significantly associated with function, depressive symptoms, being female, and not living with a spouse. Informal care utilization was significantly associated with cognition, function, comorbidities, and living with a spouse or child. CONCLUSIONS: Home health and informal care utilization relate differently to patient characteristics. Utilization of home health care or informal care was not influenced by utilization of the other.

Background: Kallikreins, a subgroup of the serine protease enzyme family, are considered important prognostic biomarkers in cancer. Here, we sought to determine the prognostic value of kallikrein 7 (hk7) in ovarian cancer using a novel method of compartmentalized in situ protein analysis. Patients and methods: A tissue array composed of 150 advanced-stage ovarian cancers, uniformly treated with surgical debulking followed by platinum-paclitaxel (Taxol) combination chemotherapy, was constructed. For evaluation of kallikrein 7 protein expression, we used an immunofluorescence-based method of automated in situ quantitative measurement of protein analysis (AQUA). Results: Mean follow-up time ofthe cohort was 34.35 months. One hundred and twenty eight of 150 cases had sufficient tissue for AQUA. In univariate survival analysis, low tumor hk7 expression was associated with better outcome for overall survival (OS) and disease-free survival in 3 years (P values 0.032 and 0.037, respectively). In multivariate survival analysis, adjusting for well-characterized prognostic variables, low tumor hk7 expression level was the most significant predictor variable for OS (95% confidence interval 0.125-0.729, P = 0.007). Conclusions: High tumor hk7 protein expression is associated with inferior patient outcome in ovarian cancer. hk7 may represent a promising prognostic factor in ovarian cancer. © The Author 2008. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved.

The aim of this study was to examine the effects of the daily minimum air temperature and human-biometeorological variables, as well as their day-to-day changes, on sleep disturbances (SD) in the inhabitants of Athens, Greece. The SD dataset used for the analysis included the daily records of the psychiatric emergency unit of the Athens University Medical School for the years 1989 (with mild thermal load) and 1994 (with heavy thermal load). The meteorological variables for the estimation of the thermal indices were recorded by the meteorological station of Hellenikon, which is located at the headquarters of the Hellenic National Weather Service. The mean radiant temperature (T mrt) and the thermal indices predicted mean vote (PMV), physiologically equivalent temperature (PET) and standard effective temperature (SET*) have been analyzed. The first step was to assess the SD frequencies as a function of the meteorological and human-biometeorological variables on the basis of 10-day intervals to determine the influence of the examined variables on SD. The daily SD records were included as Poisson random variables in the applied Generalized Linear Models (GLM). The extracted results suggested that a considerable increase in SD existed in 1994 compared to 1989. This was due to the many consecutive days with heavy thermal load (PET >35°C and Tmin >23°C) in 1994 compared to the lack of such days in 1989. Furthermore, statistically significant (p<0.01) positive relationships were found between minimum air temperature, all thermal indices and SD. © SAGE Publications 2008.

Dermal exposure to hydrofluoric acid could potentially result in severe serum calcium and magnesium depletion induced by binding with fluoride anion. This report describes the case of a 48-year-old man who developed hypocalcemia and hypomagnesemia accompanied by hypokalemia-an interesting finding-following a chemical injury with exposure to 70% hydrofluoric acid. Successful treatment included administration of calcium gluconate and magnesium both intravenously and topically.

The objective of this study is to estimate the duration, frequency and intensity of precipitation extreme episodes in Cyprus, in relation with the two phases of the Eastern Mediterranean teleconnection Pattern (EMP), during winter for the period 1958–2005. A standardised teleconnection index was employed to determine the phases (positive and negative) and the strength of the EMP. The identification of the precipitation extremes was performed with the aid of four climatic indices. It was found that during the positive phase of the pattern, the length of dry periods reduces while that of wet periods increases, being followed by increase of frequency of extreme wet days and precipitation intensity. On the contrary, during the negative phase, the dry spells become longer in accordance with shortening of the wet spells, decrease of the number of extreme wet days and precipitation intensity.

Over the years giant steps have been made in the evolution of fracture fixation and the overall clinical care of patients. Better understanding of the physiological response to injury, bone biology, biomechanics and implants has led to early mobilisation of patients. A significant reduction in complications during the pre-operative and post-operative phases has also been observed, producing better functional results. A number of innovations have contributed to these improved outcomes and this article reports on the advances made in osteosynthesis and fracture care.

BACKGROUND: We report a case of intracystic hemorrhage in a mediastinal cystic parathyroid adenoma causing parathyrotoxic crisis. METHODS AND RESULTS: A 30-year-old man presented with a large neck mass, dyspnea, and abdominal pain. The patient's serum calcium and parathormone levels were elevated. Radiography showed a right tracheal deviation, ultrasonography identified a thyroid nodular goiter extending to the mediastinum with a large (4.0 cm x 5.6 cm) cystic mass adjacent to the lower left thyroid pole. After IV fluid, pamidronate, and furosemide were administered, the patient underwent total thyroidectomy, and excision of the cyst and a small mass (2 cm x 2 cm) adjacent to the upper right thyroid lobe. Histopathologic examination revealed a double parathyroid adenoma and identified the mediastinal lesion as a cystic adenoma with intracystic hemorrhage. CONCLUSIONS: Intracystic hemorrhage in a functional mediastinal cystic parathyroid adenoma is an extremely rare cause of parathyrotoxic crisis. Aggressive medical treatment should be immediately instituted, and surgery should be performed as soon as hypercalcemia is controlled.

The geomorphological processes, which take place on the coastal zone, are influenced by a number of environmental factors, such as lithology, climate, biota, and oceanography. The present study investigated the causes of erosion taking place on the beach zones and on the coastal cliffs along the Island of Samos (eastern Aegean Sea). On the northern part of the island the coastline is characterised mainly by rocky and craggy coasts with the beach zones to be limited and in the form of a ‘pocket’ type of beach, while on the southern part by wide and long beach zones constituted by cobbles and pebbles. Intense coastal erosion takes place mainly on the rocky coasts on the northern and especially on the northwestern part of the island. In some coastal places intense coastal erosion causes problems not only to the infrastructure (road network), but also to near-coast people’s properties. Coastal erosion is more intense on the northern coasts, than on the southern coasts, due to the differenced in the incoming wave energy, which is dominated by the more intense and frequent blowing northerly winds. Furthermore, it seems that coastline retreat is more often along parts of the coast consisting of marles, malry limestones and limestones.

The shallow bay of St. Georgios is situated in the northwestern part of the Naxos Island and it is characterized by a 2.7 km long sandy coast consisting of fine-grained (sandy) material. Sand dunes are the landward limit of the beach zone, whilst at the southwestern part of the coast an extensive lagoon plain has been formed. A partially emerged reef and the morphologically associated Manto islet protect the middle and southwestern part of the beach zone from the most frequent (>40% annually) incoming N waves and the highest NW waves (>3 m). The coastal zone is under erosion as shown by the reduction in size (>50%) of the Manto islet and the extensive erosion of the foredunes, despite the reduction of the incoming wave energy due to the reef presence. The continuous erosion (lowering) of the reef in connection with the expected eustatic sea level rise is anticipated to cause further retreat of the shoreline, demolishing the sand dune field and inundating the nearby low-lying hinterland area.

Airborne particulate matter (PM10, PM2.5, PM1) and volatile organic compounds (benzene, toluene, m,p-xylene, o-xylene) samples were collected during winter and summer seasons of 2005 at two sites, representing an urban and a suburban region of the Greater Athens Area. Urban site traffic emissions were the major contributor to the concentration of PM2.5, PM10, toluene, and xylenes, while benzene and PM1 concentrations were presented in significant spatial variations. K+, Na+, Mg2+, Ca2+, NO3 -, Cl- and SO4 2 - ions were analyzed for the chemical characterization of the collected PM samples. The results showed that Na+ cations and SO4 2 - anions were the dominant species, during winter and summer, respectively, in both sites. The analysis of the synoptic scale and mesoscale atmospheric circulation during the experimental periods demonstrated that the meteorological conditions play a key role, not only in the variation but also in the distribution of the ionic concentrations at the three fractions of particulates and the dominant character (alkaline/acidic/neutral) of the particulates at the two sampling sites. © 2008 Elsevier Ltd. All rights reserved.

La présente étude traite des liens, qui unissent Lacarrière, connaisseur de l’histoire de l’art, à l’art occidental. En nous appuyant sur ses essais, ses préfaces et les catalogues d’expositions qu’il a rédigés, ainsi que sur ses collaborations avec des artistes dans le cadre d’éditions artistiques, nous présentons ses préférences esthétiques et nous révélons certaines de ses sources d’inspirations. Après avoir abordé sa révision du mythe d’Icare dans l’art, nous examinons sa description de l’atelier Brancusi. Ensuite, nous analysons la présentation des artistes français dans des préfaces et des catalogues rédigés à l’occasion des expositions. Dans Aristide Caillaud l’enchanteur 1902-1990  (2001), Lacarrière, qui établit le lien entre les créations de l’artiste et sa vie personnelle, nous fait découvrir son univers. Finalement, nous étudions les créations artistiques, qui ont illustré ses récits.

This study focuses on the importance of Dance— and its relationship to music, poetry and gymnastics— as a means and an element of education in the historical context of the classical period (5th-4th centuries B.C.) Certainly Greek literature and archaeological finds provide a rich source for the study of dance as a social and cultural phenomenon (Plato, Aristotle, Xenophon, Demosthenes, Herodotus, et al.). As a socio-cultural expression it reflected all personal, private, group, religious, and public emotions, in other words all joys, grief and major events in the daily life of the people and the state. Dance was considered a divine inspiration in which women, men and children participated The festivals in each Greek city were regarded as “the most humane and kindly institutions in their life” and the gods, were worshipped at these festivals “not in sadness, but with joy”(Mahaffy, 1879:79). During the era of Pericles, renowned figures, such as Sophocles, Epaminondas, Aeschylus and Aristophanes danced in front of audiences. ‘Professionalization’, namely dance masters/instructors enjoyed the highest esteem, professional dancers excelled, and the state encouraged, or rather financially supported the public to attend the theatre. In contrast to the gender exclusion in the palaistras where adolescent males exercised and received dance lessons, as well as the non-participation of women in athletic competitions— with the exception of Sparta— women in the 5th and 4th centuries B.C. participated in the dance process and were allowed to join in the dance processions to honor the gods, goddesses, deities, local or deceased heroes, athletic heroes, etc.   Keywords: dance as a socio-cultural expression, education of mind and soma (body), “the joy of dance” (Terpsichore), gender and dance, “free citizens with useful bodies” (Plato), professionalization, dance professionals.

La présente étude analyse les rapports de Jacques Lacarrière avec l’art grec. Sa première partie, qui s’appuie sur sa préface de L’érotisme sculpté (2005) et sur les entrées de son Dictionnaire amoureux de la Grèce (2001) ainsi que sur sa communication sur la Corè de Samos (2001) traite de sa perception de la sculpture grecque ancienne. Lacarrière ne s’est pas limité à l’analyse esthétique de l’art de la Grèce ancienne, mais a voulu tracer son évolution. La deuxième partie notre article étudie sa perception de l’oeuvre des artistes grecs contemporains (Alkis Pierrakos, Yannis Tsarouchis, Alecos Fassianos). L’écrivain, qui a souvent présenté les oeuvres des artistes grecs dans le cadre d’expositions individuelles et collectives présentées dans des galeries et musées grecs et français, était influencé par leur esthétique, mise en lumière dans ses écrits.

Objective - Genetic polymorphisms in the gene for endothelial nitric oxide synthase have been considered as potential risk factors for the development of coronary artery disease in some populations. Methods - We studied two polymorphisms of the NOS3 gene, the VNTR in intron 4 (4VNTR) and the Glu298Asp polymorphism in exon 7, in relation to the existence of premature coronary artery disease and the occurrence of myocardial infarction. A total number of 370 individuals of the Greek population was examined by PCR-RFLP method. The patient group consisted of 209 subjects, aged less than 58 years presenting symptomatic coronary artery disease, documented by coronary angiography. Results - The frequencies for bb, ab and aa genotypes of 4VNTR polymorphism were 0.67, 0.29, 0.04, respectively, for the patient group and 0.73, 0.24, 0.03 for the control group. The frequencies for GG (Glu/ Glu), GT (Glu/Asp), TT (Asp/Asp) of the Glu298Asp polymorphism were 0.52, 0.41, 0.07, respectively, in patients compared to 0.47, 0.46, 0.07, in control subjects. Statistical analysis indicated that there are no significant differences in the frequencies of the genotypes between patients and control subjects for both polymorphisms. The combined analysis of the two polymorphisms indicated no synergistic effect of the a and T alleles on coronary artery disease. Conclusions - We have found no evidence for association between the a allele of the 4VNTR polymorphism, or the T allele of Glu298Asp polymorphism and the risk for premature coronary artery disease or occurrence of myocardial infarction. Furthermore, no synergistic contribution of these polymorphisms to the development of premature coronary artery disease has been observed.

This analysis assessed the efficacy and safety of lenalidomide + dexamethasone in patients with relapsed or refractory multiple myeloma (MM) previously treated with thalidomide. Of 704 patients, 39% were thalidomide exposed. Thalidomide-exposed patients had more prior lines of therapy and longer duration of myeloma than thalidomide-naive patients. Lenalidomide + dexamethasone led to higher overall response rate (ORR), longer time to progression (TTP), and progression-free survival (PFS) versus placebo + dexamethasone despite prior thalidomide exposure. Among lenalidomide + dexamethasone-treated patients, ORR was higher in thalidomide-naive versus thalidomide-exposed patients (P = .04), with longer median TTP (P = .04) and PFS (P = .02). Likewise for dexamethasone alone-treated patients (P = .03 for ORR, P = .03 for TTP, P = .06 for PFS). Prior thalidomide did not affect survival in lenalidomide + dexamethasone-treated patients (36.1 vs 33.3 months, P > .05). Thalidomide-naive and thalidomide-exposed patients had similar toxicities. Lenalidomide + dexamethasone resulted in higher rates of venous thromboembolism, myelosuppression, and infections versus placebo + dexamethasone, independent of prior thalidomide exposure. Lenalidomide + dexamethasone was superior to placebo + dexamethasone, independent of prior thalidomide exposure. Although prior thalidomide may have contributed to inferior TTP and PFS compared with thalidomide-naive patients, these parameters remained superior compared with placebo + dexamethasone; similar benefits compared with placebo + dexamethasone were not evident for thalidomide-exposed patients in terms of overall survival. Studies were registered at http://www.clinicaltrials. gov under NCT00056160 and NCT00424047. © 2008 by The American Society of Hematology.

OBJECTIVE: In obese postmenopausal women with normal glucose metabolism (NGT) and impaired glucose tolerance (IGT) we assessed serum leptin, adiponectin, resistin, soluble leptin receptor (sOB-R) during oral glucose tolerance test (OGTT) in order to investigate their response to acute changes in glucose and insulin in the abnormal glucose metabolism, as it is early detected by IGT. METHODS: Thirty in total, overweight/obese postmenopausal women, were included in the study: 15 with NGT and 15 with IGT as it was diagnosed by OGTT. Serum glucose and insulin levels were measured at 30 min intervals, leptin, sOB-R, adiponectin and resistin at 60 min intervals during the 120 min OGTT. RESULTS: In fasting state, leptin, adiponectin, resistin and sOB-R levels did not differ between the two groups. In women with NGT, leptin was positively correlated with BMI, insulin and HOMA, and negatively correlated with QUICKI and with sOB-R; adiponectin was negatively correlated with insulin and HOMA and positively correlated with QUICKI. In women with IGT, resistin was positively correlated with BMI and waist circumference. In both groups, sOB-R was negatively correlated with insulin. During OGTT, in both groups, leptin concentration increased significantly and fasting glucose predicts significantly serum leptin change; there was no change in adiponectin, resistin and sOB-R concentrations. CONCLUSION: In overweight/obese postmenopausal women fat distribution does not affect leptin and adiponectin production. Abnormal glucose metabolism is not accompanied by disturbance in adipokines production. Leptin secretion is acutely regulated by glucose levels in insulin presence.

Cette étude ambitionne d’éclairer un aspect de la voie singulière tracée par Simone de Beauvoir au sein de l’Université où elle fut professeure de philosophie entre 1931 et 1941 : l’acte de voyager. La réflexion proposée tente d’inscrire les voyages beauvoiriens « outre France » (1931-1938) dans le contexte plus vaste de l’expérience viatique d’avant-guerre des enseignantes du secondaire, afin de mettre en évidence le caractère spécifique des pérégrinations de cette professeure de passage. Dans cette perspective, le récit viatique de Beauvoir incorporé dans son oeuvre autobiographique La force de l’âge (avec des renvois à sa correspondance personnelle avec Jean Paul Sartre et Jacques-Laurent Bost): est étudié en confrontation avec les textes de six enseignantes et anciennes Sévriennes publiés entre 1938 et 1934 dans le Bulletin de l’Association des élèves et anciennes élèves de Sèvres.Compte tenu de l’hétérogénéité relative du corpus, de la pluralité des discours et de la diversité des voix qui interviennent en chassé-croisé, cette analyse comparative permet de faire surgir l’originalité du récit de Simone de Beauvoir. Les textes des six Sévriennes transmis au sein d’un réseau universitaire ont clairement un but pédagogique : en privilégiant une approche de l’altérité qui respecte le discours hégémonique de l'époque, ils visent en premier lieu à informer, à instruire sinon à inciter au voyage. Leurs auteurs font ainsi de l’acte d’écrire un acte social. À l’opposé, la narration de Simone de Beauvoir relate un voyage individuel dont le but est la recherche d’un bonheur égoïste à travers la découverte d’un monde culturellement et socialement différent. L’acte de publicité est dans une optique d’utilité sociale entièrement gratuit : il s’agit d’un acte de création littéraire à travers lequel est assouvi encore une fois un besoin personnel.

The aim of this study was to examine the associations between loneliness/social dissatisfaction and teacher-identified behavioural risk during late childhood. A broad range of behaviour problems, as well as academic adjustment, are assessed, in order to specify in which types of behaviour and academic problems loneliness/social dissatisfaction is most likely to occur. Forty-six fifth and sixth graders who were in the borderline or clinical spectrum on the basis of their total Teacher's Report Form score completed the Children's Loneliness and Social Dissatisfaction Scale, and were compared with 50 students who did not have behaviour problems. Overall, the behaviourally at-risk group experienced more loneliness/social dissatisfaction than the comparison group. Loneliness was a more strong correlate of the variables studied than social dissatisfaction. For the behaviourally at-risk students, the strongest positive associations were found between loneliness and social problems, withdrawn/depressed behaviour and inattention; a trend for a negative association between loneliness and hyperactivity/impulsivity, as well as rule-breaking behaviour was also found. Children having both internalizing and externalizing problems experienced more loneliness than children with either internalizing or externalizing problems. Academic adjustment (i.e. academic performance, how much a student is learning and how happy he/she is) had negative links with loneliness. Several hypothetical explanations are offered and suggestions for research and action are made.

Tail loss is an effective antipredator strategy in many lizards. After loss the tail continues to thrash vigorously and may distract predators away from the escaping lizard. However, autotomy imposes energetic and survival costs (loss of lipid reserves, reduction of reproductive output, impairment of locomotor performance). Autotomy may have been lost when costs exceed benefits, while a substantial reduction or full loss may occur during ontogeny. The Balkan green lizard, Lacerta trilineata is a skilful sprinter despite its robust structure. Predation was simulated in a total of 83 individuals (48 juveniles and 35 adults). All juveniles shed their tail readily while none of the adults autotomized their tails. Postautotomyduration of movement and levels of involving metabolites in shed tails were measured. No differences were found on comparison to other Greek lacertids. These findings suggest that autotomic ability is lost ontogenetically in L. trilineata while post-autotomy energetics seems to be a conservative character.

Background: The aim was to examine characteristics and treatment results of patients with mucosa-associated lymphoid tissue (MALT) non-Hodgkin's lymphomas. Patients and methods: Epidemiological and clinical features of 97 patients with MALT lymphoma from the Hellenic Cooperative Oncology Group registry were analysed retrospectively for their prognostic significance in progression-free survival (PFS) and overall survival (OS). Comparisons were made between patients with gastric and nongastric sites of primary lymphoma and between different therapeutic modalities. Results: Sixty-five patients presented with gastric and 32 with nongastric lymphomas. The most frequent locations of nongastric lymphomas were the bowel, lung and parotid. Gastric lymphomas occurred more frequently in males and younger patients compared with nongastric lymphomas. Seventy-four per cent of patients had early (Ann Arbor stages I-II) and 26% had advanced (stages III-IV) disease. The median PFS for the entire population was 44 months. At 5 years, 47% of patients were progression free and the OS rate was 80%. The most reliable prognostic factor for PFS and OS was the Ann Arbor stage; 5-year PFS was 67% versus 13% and 5-year OS 91% versus 51% for patients with early versus advanced disease, respectively (P < 0.001). Of the patients treated with chemotherapy only, 87% achieved an objective response and 71% complete response. Surgery did not offer survival benefit compared with chemotherapy in localised gastric lymphoma. Conclusion: MALT lymphomas represent a distinct disease entity with widespread extranodal origin, indolent clinical course and high chemosensitivity. Ann Arbor stage was the most reliable prognostic and predictive factor. © The Author 2007. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved.

We propose a new method for the rejection of the comparatively strong diamagnetic contribution usually observed in SQUID magnetization measurements, originating from the substrates that are widely used for the preparation of thin magnetic films either by sputtering or by laser ablation techniques. Our method relies on the use of a substrate of length exceeding significantly the scan length employed in the magnetization measurements. Simple symmetry considerations reveal that the substrate's signal can be removed efficiently. This is also verified by a simple quantitative model, which is based on the form of total response of the four SQUID pick-up coils for a long sample. Our experimental data show clear evidence that the direct rejection of the substrate's undesired diamagnetic signal is complete in all the different categories of films (CoPt uniform single layers, CoPt isolated nanoparticles and La(1-x)Ca(x)MnO(3) multilayered specimens) studied in the present work. As a result, the real underlying mechanism that governs the physics of these magnetic films was uncovered. (C) 2008 Elsevier B.V. All rights reserved.

Owing to vast technological advances, hemodialysis (HD) has become a mature modality significantly increasing the survival of end-stage renal disease (ESRD) patients. However, many HD complications still exist that mainly relate to the nature of middle-molecular-weight and/or protein-bound toxins that both low- and high-flux dialysers cannot efficiently remove. For instance, hyperhomocysteinemia and amyloidosis are two dialysis-related disorders that motivate serious health complications. Here, we introduce a new method for the selective removal of specific toxins that is based on the preparation of Ferromagnetic Nanoparticle-Targeted Binding Substance Conjugates (FN-TBS Cs) constituted of biocompatible FNs and a specifically designed TBS that must have high affinity for the respective Target Toxin Substance (TTS). The FN-TBS Cs should be administered to the patient timely prior to the dialysis session so that they will be able to bind with the specific TTS owing to their free circulation in the bloodstream. The complex FN-TBS-TTS can be selectively removed from the ESRD patient during the HD session by means of a magnetic dialyser (MD). For the in vitro evaluation of this proposal we employed highly biocompatible Fe3O4 and Bovine Serum Albumin (BSA) as constituents of the FN-TBS Cs and an array of permanent magnets placed along the circulation line as a simple MD. We have evaluated the binding affinity and capacity of both bare Fe3O4 FNs and Fe3O4-BSA Cs by employing homocysteine (Hcy) as a model TTS. We investigate Hcy concentrations ranging from mild to severe hyperhomocysteinemia. Most importantly, we investigate the effectiveness of low concentrations of Fe3O4 that are within the safety levels established from the treatment of iron-deficiency anemia, thus making a preliminary evaluation of future in vivo applications. We observed that Hcy is readily adsorbed onto both bare Fe3O4 FNs and Fe3O4-BSA Cs. The obtained results prove the successful in vitro applicability of the proposed method since pathological Hcy concentrations may be adequately handled by relatively low Fe3O4 concentrations, thus making feasible future in vivo applications.

By using x-ray diffraction, magnetization and Mossbauer spectroscopy techniques we have studied the magnetoelectric Al2-xFexO3 (x = 0.8, 0.9 and 1.0) compound. Ac-susceptibility and magnetization measurements revealed magnetic transitions at T-N = 180, 210 and 260 K for x = 0.8, 0.9 and 1.0 respectively, that can be attributed to the Neel temperatures of ferrimagnetic to paramagnetic phase transition for all samples. Mossbauer spectra for the three samples were recorded between 4.2 and 295 K. Above the Neel temperature the paramagnetic spectra can be analyzed by three quadrupole doublets associated with the octahedral Fe1, Fe2 and Fe4 sites. The values of the hyperfine parameters show that iron ions are in the high spin Fe3+ state. The spectrum area of the doublet with larger quadrupole splitting increases with x, and in combination with x-ray diffraction results it can be attributed to the iron which occupies the Fe4 site. Below T-N(x) the Mossbauer spectra are magnetically split and at T = 4.2 K consist of six broad lines, indicating either a hyperfine magnetic field distribution (P(H-hyp)) or that the three octahedral sites give three unresolved sextets. The most probable value of H-hyp (the maximum value of P(H-hyp)) follows a power law indicative of a second order transition, in agreement with ac-susceptibility and magnetization measurements. The width of P(H-hyp) increases drastically toward low hyperfine magnetic fields as temperature increases. In addition, an appreciable percentage of the iron nuclei sense a hyperfine field with values in the interval [0, H-max]. This behavior can be explained by assuming that several magnetic sites with different superexchange parameters exist.

The magnetic properties of nanocrystalline titanium carbide dispersed in a carbon matrix (TiCx/C) prepared by the non-hydrolytic sol-gel process have been studied by dc magnetization measurements. The superconducting phase of titanium carbide has been observed at low temperatures with the onset of the superconducting transition temperature Tc at about 3.5 K, superimposed on a ferromagnetic component. At T > Tc the magnetic response of TiCx/C is determined by the interplay of the ferromagnetic contribution with the paramagnetic/diamagnetic signal of the metallic system and the contribution of exchange coupled paramagnetic ions. Moreover, significant differences are observed in the magnetic response for samples of the same preparation batch, indicative of the magnetic/electronic inhomogeneity of nanocrystalline titanium carbide which is important for its practical applications.

The magnetic properties of γ-Fe 2O 3 nanoparticles embedded in a thermoplastic elastomer poly(ether-ester) copolymer by the in situ polycondensation reaction process have been investigated by means of magnetization and ferromagnetic resonance (FMR) measurements at low filler concentrations of 0.1 and 0.3 wt% with the magnetic additive introduced in the polymer matrix in powder and solution form. The magnetic behavior of the magnetopolymeric nanocomposites indicates significant interparticle interaction effects that depend mainly on the dispersion state of the magnetic nanoparticles as well as their concentration, consistent with the variation of the particle microstructure characterized by magnetic aggregates in the nanometer and micron scale for the solution and powder dispersions, respectively. The magnetization and FMR results at different filler concentrations and dispersions show a close correspondence to the relaxation processes of the copolymer, implying the coupling of polymeric and magnetic properties. Copyright © 2008 American Scientific Publishers All rights reserved.

The main characteristics of relativistic, steady, ideal magnetohydrodynamic (MHD) outflows are discussed, focusing on their bulk acceleration and collimation. It is shown that the Bernoulli equation relates the bulk Lorentz factor with the shape of the flow, permitting an analytic estimation of the acceleration efficiency, while the transfield force-balance equation gives a simple relation of the bulk Lorentz factor to the distance.

OBJECTIVE: To determine if baseline measurements of cerebral atrophy and severity of white matter hyperintensity (WMH) predict the rate of future cognitive decline in patients with Alzheimer disease (AD). DESIGN: Data were drawn from the Predictors Study, a longitudinal study that enrolls patients with mild AD and reassesses them every 6 months with use of the Columbia modified Mini-Mental State (mMMS) examination (score range, 0-57). Magnetic resonance images were analyzed to determine the severity of WMH, using the Scheltens scale, and the degree of atrophy, using the bicaudate ratio. Generalized estimating equations were used to determine whether severity of baseline magnetic resonance image measurements and their interaction predicted the rate of mMMS score decline at subsequent visits. SETTING: Three university-based AD centers in the United States. PARTICIPANTS: At baseline, 84 patients with AD from the Predictors Study received structural magnetic resonance imaging and were selected for analysis. They had a mean of 6 follow-up evaluations. Main Outcome Measure The mMMS score. RESULTS: Generalized estimating equation models demonstrated that the degree of baseline atrophy (beta = -0.316; P = .04), the severity of WMH (beta = -0.173; P = .03), and their interaction (beta = -6.061; P = .02) predicted the rate of decline in mMMS scores. CONCLUSIONS: Both degree of cerebral atrophy and severity of WMH are associated with the rapidity of cognitive decline in AD. Atrophy and WMH may have a synergistic effect on future decline in AD, such that patients with a high degree of both have a particularly precipitous cognitive course. These findings lend further support to the hypothesis that cerebrovascular pathological abnormalities contribute to the clinical syndrome of AD.

Background: Cycloxygenase (COX)-2 has been associated with proliferation, apoptosis and angiogenesis in urothelial cancer. The prognostic significance of COX-2 in patients who received adjuvant chemotherapy for urothelial cancer was examined. Patients and Methods: Expression of COX-2, p53, ki67, β-catenin, vascular endothelial growth factor (VEGF) and microvessel density (MVD) were studied retrospectively in 59 patients with urothelial cancer (pT3, pT4, N+) who had undergone surgery. The patients had subsequently received adjuvant chemotherapy. Results: Thirty-eight out of 59 cases (64% ) were positive for COX-2. COX-2 was not associated either with progression-free survival (PFS) or overall survival (OS). MVD levels ≥47 were associated with longer median PFS compared with lower levels (not reached vs. 13 months [95% CI: 8-18], p=0.048). The median PFS for patients with β-catenin nuclear accumulation and COX-2 expression was 6 months (95% CI: 4-7) compared with 19 months (95% CI: 14-23) for neither or only one of these factors (p=0.018). Conclusion: MVD may be a useful indicator of relapse in high-risk urothelial cancer treated with adjuvant chemotherapy.

The recent revision of Verticillium sect. Prostrata led to the introduction of the genus Lecanicillium, which comprises the majority of the entomopathogenic strains. Sixty-five strains previously classified as Verticillium lecanii or Verticillium sp. from different geographical regions and hosts were examined and their phylogenetic relationships were determined using sequences from three mitochondrial (mt) genes [the small rRNA subunit (rns), the NADH dehydrogenase subunits 1 (nad1) and 3 (nad3)] and the ITS region. In general, single gene phylogenetic trees differentiated and placed the strains examined in well-supported (by BS analysis) groups of L. lecanii, L. longisporum, L. muscarium, and L. nodulosum, although in some cases a few uncertainties still remained. nad1 was the most informative single gene in phylogenetic analyses and was also found to contain group I introns with putative open reading frames (ORFs) encoding for GIY-YIG endonucleases. The combined use of mt gene sequences resolved taxonomic uncertainties arisen from ITS analysis and, alone or in combination with ITS sequences, helped in placing uncharacterised Verticillium lecanii and Verticillium sp. firmly into Lecanicillium species. Combined gene data from all the mt genes and all the mt genes and the ITS region together, were very similar. Furthermore, a relaxed correlation with host specificity -- at least for Homoptera -- was indicated for the rns and the combined mt gene sequences. Thus, the usefulness of mt gene sequences as a convenient molecular tool in phylogenetic studies of entomopathogenic fungi was demonstrated.

Purpose: There are major differences affecting genes in adenocarcinomas in ever and never smokers. However, data on whether mitogen-activated protein kinase (MAPK) activation state differs according to smoking status are limited. Experimental Design: Expression of activated extracellular signal - regulated kinases, c-Jun NH2-terminal kinases, and P38 enzymes (pP38) were evaluated by means of immunohistochemistry in 188 chemonaïve patients with surgically resected lung adenocarcinoma. Cell viability of the lung adenocarcinoma cell line HCC827 was studied after treatment with cisplatin or the P38 MAPK inhibitor SB 203580. Results: Thirty-seven of 44 never smokers [84%; 95% confidence intervals (95% CI), 70-92%] expressed high pP38 levels compared with 45 of 104 ever smokers (43%; 95% CI, 34-53%; P < 0.0001). The proportion of never smokers expressing high c-Jun NH2-terminal kinase levels (72%; 95% CI, 57-83%) was greater than that of ever smokers (53%; 95% CI, 44-62%; P = 0.03). The proportion of ever smokers expressing high extracellular signal - regulated kinase levels (51%; 95% CI, 42-59%) was similar to that of never smokers (57%; 95% CI, 42-71%; P = 0.47). Never smokers were 10.5 times (95% CI, 3.5-31.5) more likely to express high pP38 levels after adjustment for variables linked to smoking status, including age, sex, and histologic subtype. None of the activated MAPKs predicted for overall survival. Cell viability of HCC827 was significantly reduced after exposure to SB203580 alone or when combined with cisplatin. Conclusions: Life-long nonsmoking is associated with high activated P38 levels in patients with lung adenocarcinoma. Activated P38 can contribute to the viability of adenocarcinoma cells in never smokers, but is not predictive for overall survival. © 2008 American Association for Cancer Research.

In the recent years, studies of hepatitis B (HBV) and hepatitis C virus (HCV) dynamics have drawn great attention as they provide insight into the process of virus elimination/production and of infected cells decay during antiviral treatment. Estimates of viral dynamic parameters may be used to determine the lifetime of HCV/HBV virions and of infected cells, to estimate how long patients need to be treated and to evaluate antiviral therapies. The implementation of viral dynamics studies is difficult because they involve an intensive blood-sampling schedule and subsequent viral load quantification. In the majority of these studies, a model proposed by Neumann et al. (Science 1998; 282:103-107) is used under various assumptions, such as ignoring the delay in initial viral load decay, assuming time-constant treatment efficacy in reducing virion production and/or complete blocking of new infections, etc. However, only recently the effect of some of these assumptions on the estimated parameters has been evaluated. In this paper we provide a detailed review of the model, its underlying assumptions as well as the assumptions usually made by researchers during the design and analysis of viral dynamics studies. Then, we investigate the effect of these assumptions on the estimated parameters using simulations and draw useful conclusions concerning the analysis of these studies. Real data examples from a clinical trial on hepatitis B are provided as illustrations.

Immune responses to rhinovirus (RV) as well as direct effects of RV on respiratory epithelium may contribute to the induction of asthma exacerbations.|To evaluate the effect of the environment resulting from an atopic immune response on RV-induced epithelial inflammation, replication and cytotoxicity.|Peripheral blood mononuclear cells (PBMC) from atopic asthmatic subjects and matched controls (12 pairs) were isolated and stimulated by RVs. Human bronchial epithelial (BEAS-2B) cells were infected with RV in the presence of conditioned media from RV-stimulated PBMC cultures. IL-6, IL-8, RANTES and TGF-beta1 levels were measured by ELISA, RV-induced cytotoxicity by a colorimetric method and RV titres on Ohio-HeLa cells.|RV-induced epithelial production of IL-6, IL-8 and RANTES was significantly lower, while TGF-beta1 was higher when cells were exposed to conditioned media from atopic asthmatic subjects compared with those from normal controls. Exposure to the 'atopic' environment also resulted in elevated RV titres and increased RV-induced cytotoxicity.|Under the influence of an atopic environment, the epithelial inflammatory response to RV is down-regulated, associated with increased viral proliferation and augmented cell damage, while TGF is up-regulated. These changes may help explain the propensity of atopic asthmatic individuals to develop lower airway symptoms after respiratory infections and indicate a mechanism through which viral infections may promote airway remodelling.

Sarcomeric filament proteins display extraordinary properties in terms of protein length and mechanical elasticity, requiring specific anchoring and assembly mechanisms. To establish the molecular basis of terminal filament assembly, we have selected the sarcomeric M-band protein myomesin as a prototypic filament model. The crystal structure of the myomesin C-terminus, comprising a tandem array of two immunoglobulin (Ig) domains My12 and My13, reveals a dimeric end-to-end filament of 14.3 nm length. Although the two domains share the same fold, an unexpected rearrangement of one beta-strand reveals how they are evolved into unrelated functions, terminal filament assembly (My13) and filament propagation (My12). The two domains are connected by a six-turn alpha-helix, of which two turns are void of any interactions with other protein parts. Thus, the overall structure of the assembled myomesin C-terminus resembles a three-body beads-on-the-string model with potentially elastic properties. We predict that the found My12-helix-My13 domain topology may provide a structural template for the filament architecture of the entire C-terminal Ig domain array My9-My13 of myomesin.

AIM: To examine whether isolates of the entomopathogenic fungus Beauveria bassiana are more closely associated to their summer hosts compared with overwintering hosts, with recently developed molecular tools based on mitochondrial regions. METHODS AND RESULTS: Primers for the traditional ITS1-5.8S-ITS2 region and two mitochondrial intergenic regions, namely, nad3-atp9 and atp6-rns, were used. All amplified products were sequenced, aligned and Neighbour-Joining (NJ), parsimony and Bayesian phylogenetic inference analyses were performed. The isolates examined were grouped with very good support into three distinct groups, two of them showed geographical correlation, but no clear association to their host. CONCLUSIONS: The mitochondrial intergenic regions used were more informative than the nuclear ITS1-5.8S-ITS2 sequences. The sequence variability observed, that allowed the phylogenetic placement of the isolates into distinct groups, depended on the geographical origin of the isolates and can be exploited for designing group-specific and isolate-specific primers for their genetic fingerprinting. No clear associations with summer Sunn Pest populations were observed. SIGNIFICANCE AND IMPACT OF THE STUDY: Studies on the genetic variability of biocontrol agents like B. bassiana are indispensable for the development of molecular tools for their future monitoring.

We have studied drug release from matrices with periodic layers of high and low diffusivity using Monte Carlo simulations. Despite the fact, that the differential equations relevant to this process have a form that is quite different from the classical diffusion equation with constant diffusion coefficient, we have found that the Weibull model continues to describe the release process as well as in the case of the ``classical{''} diffusion controlled drug release. We examine the similarities and differences between release from matrices with periodic layers and matrices with random mixtures of high and low diffusivity area and show that the periodic geometrical arrangement of the low diffusivity areas has an influence in the release profile which is negligible for low diffusivity ratios, but becomes important in the case of high diffusivity ratios and for intermediate values of the periodic ``length{''}. Such an arrangement in periodic layers leads to Weibull exponent a which are lower than those of the corresponding random arrangement and exponents b which are higher than those of the random case. (C) 2007 Elsevier B.V. All rights reserved.

In this work, the morphology, structure, surface chemical composition, and optical properties of very thin (10-70 nm) anodic silicon films grown on a silicon substrate by electrochemical dissolution of bulk crystalline silicon in the transition regime between the porous formation and electropolishing were investigated in detail. Anodization was performed by using short single pulses of anodization current in low and high hydrofluoric acid (HF) concentration electrolytes. A systematic comparison was made between films grown at low and high HF concentration electrolytes. The morphology and structure of the films were investigated by combining atomic force microscopy and transmission electron microscopy (TEM), while x-ray and ultraviolet photoelectron spectroscopies were used to investigate the chemical composition of the films. Photoluminescence was used to investigate the optical properties. It was found that films that formed at low HF concentrations were much thinner than films that formed at high HF concentrations due to surface dissolution of the films during anodization. High resolution TEM images revealed an amorphouslike structure (porous) in all of the films in which discrete Si nanocrystals (NCs) were identified. NC size was, on the average, larger in films fabricated in low HF concentration electrolytes and these films were not luminescent. On the other hand, films fabricated in high HF concentration electrolytes were thicker and contained smaller NCs. A silicon oxide layer covered the internal surface of all films, this oxide being much thinner in films grown at high HF concentrations. This last effect was attributed to self-limiting oxidation of the very small NCs constituting these films. © 2008 American Institute of Physics.