The central engine in long gamma-ray bursts (GRBs) is thought to be a compact object produced by the core collapse of massive stars, but its exact nature (black hole or millisecond magnetar) is still debatable. Although the central engine of GRB collapsars is hidden to direct observation, its properties may be imprinted on the accompanying electromagnetic signals. We aim to decipher the generic properties of central engines that are consistent with prompt observations of long GRBs detected by the Burst Alert Telescope (BAT) on board the Neil Gehrels Swift Observatory. Adopting a generic model for the central engine, in which the engine power and activity time-scale are independent of each other, we perform Monte Carlo simulations of long GRBs produced by jets that successfully breakout from the star. Our simulations consider the dependence of the jet breakout time-scale on the engine luminosity and the effects of the detector's flux threshold. The two-dimensional (2D) distribution of simulated detectable bursts in the gamma-ray luminosity versus gamma-ray duration plane is consistent with the observed one for a range of parameter values describing the central engine. The intrinsic 2D distribution of simulated collapsar GRBs peaks at lower gamma-ray luminosities and longer durations than the observed one, a prediction that can be tested in the future with more sensitive detectors. Black hole accretors, whose power and activity time are set by the large-scale magnetic flux through the progenitor star and stellar structure, respectively, are compatible with the properties of the central engine inferred by our model.

Sentiment analysis is a vigorous research area, with many application domains. In this work, aspect-based sentiment prediction is examined as a component of a larger architecture that crawls, indexes and stores documents from a wide variety of online sources, including the most popular social networks. The textual part of the collected information is processed by a hybrid bi-directional long short-term memory architecture, coupled with convolutional layers along with an attention mechanism. The extracted textual features are then combined with other characteristics, such as the number of repetitions, the type and frequency of emoji ideograms in a fully-connected, feed-forward artificial neural network that performs the final prediction task. The obtained results, especially for the negative sentiment class, which is of particular importance in certain cases, are encouraging, underlying the robustness of the proposed approach.

{This research provides new constraints on the intermediate depth upper-mantle structure of the Hellenic lithosphere using a three-step Rayleigh-wave tomography. Broadband waveforms of about 1000 teleseismic events, recorded by ∼200 permanent broadband stations between 2010 and 2018 were acquired and processed. Through a multichannel cross-correlation technique, the fundamental mode Rayleigh-wave phase-velocity dispersion curves in the period range 30 to 90 s were derived. The phase-velocities were inverted and a 3-D shear velocity model was obtained down to the depth of 140 km. The applied method has provided 3-D constraints on large-scale characteristics of the lithosphere and the upper mantle of the Hellenic region. Highlighted resolved features include the continental and oceanic subducting slabs in the region, the result of convergence between Adria and Africa plates with the Aegean. The boundary between the oceanic and continental subduction is suggested to exist along a trench-perpendicular line that connects NW Peloponnese with N. Euboea, bridging the Hellenic Trench with the North Aegean Trough. No clear evidence for trench-perpendicular vertical slab tearing was resolved along the western part of Hellenic Subduction Zone; however, subcrustal seismicity observed along the inferred continental-oceanic subduction boundary indicates that such an implication should not be excluded. The 3-D shear velocity model supports an N-S vertical slab tear beneath SW Anatolia that justifies deepening, increase of dip and change of dip direction of the Wadati-Benioff Zone. Low velocities found at depths \< 50 km beneath the island and the back-arc, interrelated with recent/remnant volcanism in the Aegean and W. Anatolia, are explained by convection from a shallow asthenosphere.}

Aims: We use new deep XMM-Newton observations of the northern disc of M31 to trace the hot interstellar medium (ISM) in unprecedented detail and to characterise the physical properties of the X-ray emitting plasmas. Methods: We used all XMM-Newton data up to and including our new observations to produce the most detailed image yet of the hot ISM plasma in a grand design spiral galaxy such as our own. We compared the X-ray morphology to multi-wavelength studies in the literature to set it in the context of the multi-phase ISM. We performed spectral analyses on the extended emission using our new observations as they offer sufficient depth and count statistics to constrain the plasma properties. Data from the Panchromatic Hubble Andromeda Treasury were used to estimate the energy injected by massive stars and their supernovae. We compared these results to the hot gas properties. Results: The brightest emission regions were found to be correlated with populations of massive stars, notably in the 10 kpc star-forming ring. The plasma temperatures in the ring regions are ~0.2 up to ~0.6 keV. We suggest this emission is hot ISM heated in massive stellar clusters and superbubbles. We derived X-ray luminosities, densities, and pressures for the gas in each region. We also found large extended emission filling low density gaps in the dust morphology of the northern disc, notably between the 5 and 10 kpc star-forming rings. We propose that the hot gas was heated and expelled into the gaps by the populations of massive stars in the rings. Conclusions: It is clear that the massive stellar populations are responsible for heating the ISM to X-ray emitting temperatures, filling their surroundings, and possibly driving the hot gas into the low density regions. Overall, the morphology and spectra of the hot gas in the northern disc of M31 is similar to other galaxy discs. FITS files for Figs. 1 and 2 are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/cat/J/A+A/637/A12 Based on observations obtained with XMM-Newton, an ESA science mission with instruments and contributions directly funded by ESA Member States and NASA.

BACKGROUND: Although infectious diseases are globally on the decline, they remain a major global public health problem. Among them, the hepatitis B virus (HBV) or hepatitis C virus (HCV) and HIV infection are of primary interest. Valid prevalence data on these infections are sparse in Greece, especially for vulnerable populations. OBJECTIVE: This study aimed to present the design and methods of Hprolipsis, an integrated viral hepatitis and HIV screening program administered to adults (>/=18 years) from the general, Greek Roma, and migrant populations. Its aims were to estimate the prevalence of HBV, HCV, and HIV; assess infectious disease knowledge level; design, implement, and assess population-specific awareness actions; and offer individual counseling and referral when indicated and HBV vaccination to susceptible Roma and migrants. METHODS: Multistage, stratified, random sampling based on the 2011 Census was applied to select the general population sample, and nonprobability multistage quota sampling was used for Roma and migrant sample selection. Trained personnel made home (general population) or community (Roma and migrants) visits. Collected blood samples were tested for Hepatitis B surface Antigen, Hepatitis B core Antibody, Hepatitis B surface Antibody, Hepatitis C Antibody, and HIV 1,2 Antibody. The surveys were conducted during May 2013 and June 2016. To estimate an HCV prevalence of 1.5% with 0.3 precision, the required general population sample size was estimated to be 6000. As migrants constitute 10% of the whole Greek population, the migrant sample size was set to 600. A feasible sample size of 500 Greek Roma was set. RESULTS: In total, 6006 individuals from the general population (response rate 72%), 534 Greek Roma, and 612 migrants were recruited. Blood test results are available for 4245 individuals from the general population, 523 Roma, and 537 migrants. CONCLUSIONS: Hprolipsis is the first nationwide survey on HBV, HCV, and HIV. Its results will enhance our understanding of the health needs and disease burden of these diseases in the 3 studied populations. Its implementation provided useful recommendations for future studies, particularly in vulnerable populations. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/13578.

This paper examines the latest research on the digital skills crisis, focusing on the factors that contribute to digital exclusion. Through an extensive analysis of current literature on the digital divide, the authors discuss digital skills gaps, namely the exclusion of a sizeable part of the workforce from the digital market economy—and women in particular. Studies indicate that exclusion from the digital market is augmented and reinforced when combining the gender dimension with other exclusionary factors such as disability, age, race and socioeconomic background. Research confirms that the gender imbalance in ICT and related sectors persists today, despite decades of equal opportunity policies, legislation and government initiatives. Women are still underrepresented and digitally excluded and efforts to attract, recruit and retain girls and women in ICT and STEM seem to be failing, reinforcing the gender gaps: participation gap, pay gap, and leadership gap, a result of the deep-rooted gender order reflected in the latest Global Gender Gap Report and Index. A growing body of research of the twenty-first shows that inspiring girls and women into technology—increasing the talent pool in ICT and STEM— requires engendering technology, eliminating gender stereotypes, and raising the profile of female role models and mentors. Studies repeatedly argue that engendering technology entails women’s agency and economic empowerment. Accordingly, the authors include recommendations from inspirational role models and mentors, three successful women in ICT, STEM and Information Society who have made a difference. All three, following a series of semi-structured interviews, propose engendering technology to increase the female talent pool in addition to engendering STEM education, that is to say, including the gender dimension.--------------------------------------------------------------------------------- Keywords: Engendering technology, Digital divide, Digital exclusion, Gender gaps, Disability, Age, Skills gap, Women entrepreneurs, Leadership gap, Digital inequality, Gender devaluation, Digital economy------------------------------------------------**  The DOI will be activated after the issue is closed    

SIR model is widely used for modeling the infectious diseases. This is a system of ordinary differential equations (ODEs). The numbers of susceptible, infectious, or immunized individuals are the compartments in these equations and change in time. Two parameters are the factor of differentiating these models. Here, we are not interested in solving the ODEs describing a certain SIR model. Given the observed data, we try to estimate the parameters that determine the model. For this, we propose a least squares approach using second-order centered differences for replacing the derivatives appeared in the ODEs. Then we arrive at a simple linear system that can be solved explicitly and furnish the approximations of the parameters. Numerical results over various artificial data verify the simplicity and accuracy of the new method.

Supersoft X-ray sources (SSS) have been identified as white dwarfs accreting from binary companions and undergoing nuclear burning of the accreted material on their surface. Although expected to be a relatively numerous population from both binary evolution models and their identification as type Ia supernova progenitor candidates, given the very soft spectrum of SSSs relatively few are known. Here we report on the X-ray and optical properties of 1RXS J050526.3-684628, a previously unidentified accreting nuclear-burning white dwarf located in the Large Magellanic Cloud (LMC). XMM-Newton observations enabled us to study its X-ray spectrum and measure for the first time short-period oscillations of ~170 s. By analysing newly obtained X-ray data by eROSITA, together with Swift observations and archival ROSAT data, we have followed its long-term evolution over the last 3 decades. We identify 1RXS J050526.3-684628 as a slowly evolving post-nova SSS undergoing residual surface nuclear burning, which finally reached its peak in 2013 and is now declining. Though long expected on theoretical grounds, such long-lived residual-burning objects had not yet been found. By comparison with existing models, we find that the effective temperature and luminosity evolution are consistent with an ~0.7 M⊙ carbon-oxygen white dwarf accreting ${\sim} 10^{-9}~\rm {M}_{\odot }$ yr-1. Our results suggest that there may be many more undiscovered SSSs and 'missed' novae awaiting dedicated deep X-ray searches in the LMC and elsewhere.

The interannual variability and the mechanisms controlling the dissolved oxygen concentration in the Mediterranean Sea were investigated through generating gridded fields of dissolved oxygen, salinity and potential temperature. The Data-Interpolating Variational Analysis (DIVA) software was used to produce a gridded dataset for the time period 1960–2011. High oxygen concentrations for the upper and bottom layers, separated by an oxygen minimum zone at intermediate layers, are a typical structure of the dissolved oxygen in the Eastern and the Western Mediterranean sub-basins. Although an oxygen minimum zone is observed in both sub-basins, its vertical positions are different; in the Eastern Mediterranean at between 600 and 1200 m depth and in the Western Mediterranean at between 400 and 600 m. The vertical distribution of dissolved oxygen shows significant differences between the two sub-basins and their temporal evolution reveals large interannual to decadal variability. A negative correlation was observed between dissolved oxygen and surface potential temperature due to solubility changes over the whole period. However, the positive correlation between the dissolved oxygen and potential temperature in the Eastern Mediterranean deep layers is an indication that the dynamical processes are dominant and are involved in the dissolved oxygen interannual variability. The dissolved oxygen variability presents shifts with a multi-decadal signal, rather than trends as observed in the global ocean, associated with mixing processes and decadal oscillations that influence the dense water formation or biological activity.

How are women entrepreneurs transforming and challenging traditional understandings of professional success in the 21st century, despite the multitasking whirlpool? What type of knowledge and skills are required in today's digital world to develop professionally and succeed as an entrepreneur? What are the major barriers to successful entrepreneurship preventing women from realizing their full potential or stopping them from even beginning an entrepreneurial career? A current literature review (2011-2019) on women's entrepreneurial initiatives, skills, characteristics, attributes, motives and leadership styles, documenting strategies for success and barriers confronted, indicates that not much has changed. Women entrepreneurs continue to face the multitasking whirlpool, along with the lack of financial resources, marketing skills and support services, including poor access to business networks, technology and digital markets. Despite the mass entry of women in exclusively male domains, glass ceilings have not been shattered. Then again, developed and developing nations have come to understand that women's entrepreneurial activities contribute to socioeconomic growth and utilizing the full potential of all human resources is essential for sustainable development. Studies of the 21st century-as those of the late 20th century-continue to spotlight gender gaps in entrepreneurship as well as the so-valued career-family balance, while still arguing that further research is needed. They also agree that successful entrepreneurship requires digital skills along with the drive for innovation. The successful entrepreneur, or to use a term and concept coined by Elias G. Carayannis and McDonald R. Stewart (2013), the "distinguished entrepreneur" regardless of gender, is an innovator; a visionary; a person who predicts and shapes the future; takes initiatives; accepts change, risk and failure; learns from it; and sees what others do not see, among other things. Accordingly, this study presents snapshots of lives changed and empowered. It includes the work and narratives of "distinguished" (Carayannis & Stewart 2013) women entrepreneurs who have made a difference. Is it not time to shed some light on inspirational role models, especially those who are excelling in the startup world, the Blue Economy and the Silver Economy? KEYWORDS: Women, Entrepreneurship, Multitasking whirlpool, Gender participation gap, Gender pay gap, Gender leadership gap, Work–life balance, Digital skills, Degendering

Raising awareness for sustainable development and environmental consciousness is an alternative teaching approach of geosciences in primary education. Through our methodology this is achieved by strengthening teachers' profile to effectively coach students to work on several environmental issues. By creating a teacher’s guideline handbook, in accordance with the educational targets and regulations of EU countries, teachers acquire a fresh perspective on teaching environmental sciences. They also gain scientific knowledge in five educational topics through the implementation of five mini-projects. An e-book enriched with the pupils’ digitalised environmental stories was designed to attract students and motivate them to engage environmental issues. The final product acts as a triggering factor for the much-needed environmental awareness of pupils around Europe.

OBJECTIVES: Subtypes A1 and B are the most prevalent HIV-1 clades in Greece. Subtype A1 epidemic is highly monophyletic and corresponds to transmissions that occurred locally. Our aim in this molecular epidemiology analysis was to investigate the role of early treatment in preventing new HIV-1 transmissions. METHODS: Our analysis focused on 791 subtype A1 sequences from treatment-naïve individuals in Greece. Estimation of infection dates was performed by molecular clock calculations using Bayesian methods. We estimated the time interval between (1) the infection and sampling dates (linkage to care window), (2) the sampling dates and antiretroviral therapy (ART) initiation (treatment window), and (3) the infection dates and ART initiation (transmissibility window) for the study population. We also inferred the putative source of HIV infections between individuals of different groups divided according to the length of treatment, linkage to care or transmissibility window. RESULTS: A significant decline was detected for the treatment window during 2014-2015 versus the 2 previous years (p=0.0273), while the linkage to care interval remained unchanged during the study period. Inference of the putative source of HIV infections suggested that individuals with a recent diagnosis or narrow transmissibility window (time period between HIV infection and ART initiation) were not sources of HIV infections to other groups. Contrarily, a significant number of HIV infections originated from individuals with longer transmissibility window interval. CONCLUSIONS: Our findings showed that the treatment window is decreasing over time, presumably due to the updated treatment guidelines. Our study also demonstrates that people treated earlier after infection do not transmit at high rates, thus documenting the benefits of early ART initiation in preventing ongoing HIV-1 transmission.

During embryonic development, excitatory projection neurons migrate in the cerebral cortex giving rise to organised layers. Periventricular heterotopia (PH) is a group of aetiologically heterogeneous disorders in which a subpopulation of newborn projection neurons fails to initiate their radial migration to the cortex, ultimately resulting in bands or nodules of grey matter lining the lateral ventricles. Although a number of genes have been implicated in its cause, currently they only satisfactorily explain the pathogenesis of the condition for 50% of patients. Novel gene discovery is complicated by the extreme genetic heterogeneity recently described to underlie its cause. Here, we study the neurodevelopmental role of endothelin-converting enzyme-2 (ECE2) for which two biallelic variants have been identified in two separate patients with PH. Our results show that manipulation of ECE2 levels in human cerebral organoids and in the developing mouse cortex leads to ectopic localisation of neural progenitors and neurons. We uncover the role of ECE2 in neurogenesis, and mechanistically, we identify its involvement in the generation and secretion of extracellular matrix proteins in addition to cytoskeleton and adhesion.

Editorial

One of the most frequently prescribed selective serotonin reuptake inhibitor medications (SSRIs) for peripartum mood and anxiety disorders is sertraline (Zoloft®). Sertraline can help alleviate mood and anxiety symptoms in many women but it is not known how sertraline, or SSRIs in general, affect the neurobiology of the brain particularly when pregnant. The aim of this study was to investigate how sertraline affects plasticity in the hippocampus, a brain area integral in depression and SSRI efficacy (particularly in males), during late pregnancy and whether these effects differ from the effects of sertraline in non-pregnant females. To do this pregnant and age-matched non-pregnant female Sprague-Dawley rats were used. For the last half of pregnancy (10 days), and at matched points in non-pregnant females, rats were given sertraline (2.5 mg/kg/day or 10 mg/kg/day) or vehicle (0 mg/kg/day). Brains were used to investigate effects on the serotonergic system in the hippocampus and prefrontal cortex and measures of neuroplasticity in the hippocampus. Results show that pregnant females have significantly higher serum levels of sertraline compared to non-pregnant females but that rates of serotonin turnover in the hippocampus and PFC are similar between pregnant and non-pregnant females. Sertraline increased synaptophysin density in the dentate gyrus and CA3 and was associated with a decrease in cell proliferation in the dentate gyrus of non-pregnant, but not pregnant, females. During late pregnancy the hippocampus showed significant reductions in neurogenesis and increases in synaptophysin density. This research highlights the need to consider the unique effect of reproductive state on the neuropharmacology of SSRIs.

One of the most frequently prescribed selective serotonin reuptake inhibitor medications (SSRIs) for peripartum mood and anxiety disorders is sertraline (Zoloft®). Sertraline can help alleviate mood and anxiety symptoms in many women but it is not known how sertraline, or SSRIs in general, affect the neurobiology of the brain particularly when pregnant. The aim of this study was to investigate how sertraline affects plasticity in the hippocampus, a brain area integral in depression and SSRI efficacy (particularly in males), during late pregnancy and whether these effects differ from the effects of sertraline in non-pregnant females. To do this pregnant and age-matched non-pregnant female Sprague-Dawley rats were used. For the last half of pregnancy (10 days), and at matched points in non-pregnant females, rats were given sertraline (2.5 mg/kg/day or 10 mg/kg/day) or vehicle (0 mg/kg/day). Brains were used to investigate effects on the serotonergic system in the hippocampus and prefrontal cortex and measures of neuroplasticity in the hippocampus. Results show that pregnant females have significantly higher serum levels of sertraline compared to non-pregnant females but that rates of serotonin turnover in the hippocampus and PFC are similar between pregnant and non-pregnant females. Sertraline increased synaptophysin density in the dentate gyrus and CA3 and was associated with a decrease in cell proliferation in the dentate gyrus of non-pregnant, but not pregnant, females. During late pregnancy the hippocampus showed significant reductions in neurogenesis and increases in synaptophysin density. This research highlights the need to consider the unique effect of reproductive state on the neuropharmacology of SSRIs.

In the present study, we attempt to investigate the determinants of the effective corporate tax rate of companies of the European Union (EU) discriminating between northern and southern economies. We adopt in our analysis the period after the outbreak of the crisis in the Eurozone up today including some years before 2009 in the assessed period. Our empirical investigation is based on three alternative approaches to effective income tax rate based on accounting information. We investigate the determinants of ECITR assessing two sub-samples of firms from all the aforementioned industrial sectors for 16 member countries of Europe. The first sub-sample consists of firms from 12 member countries of "North" European Union and the second sub-sample consists of firms from 4 member countries of "South" European Union. The analysis covers the period 2004-2016. Estimation results point out that the effective corporate income tax rate is variously affected by firm-specific determining factors for both northern and southern economies. The relation between ECITR and determining factors is ascertained to be less significant (sensitive) during the pre-crisis period in comparison with the respective empirical findings after the outburst of the economic crisis in the European Union. Empirical findings indicate that effective corporate income tax rate is more vulnerable to financial leverage for southern economies in comparison to the northern economies signaling financing structure differences between the two EU-country groups. Finally, there is evidence that there is an indisputable and positive coexistence between business profitability and tax burden.

In the present study, we investigate the determinants of the effective corporate tax rate of some of the European Union (EU) member countries and other non-EU members. Only a few studies have analyzed the EU economies, unlike the case of the USA. In this study, we extend the analysis taking also into consideration some non-EU countries which appear strong economic cooperation with EU countries over time. The present study aims to analyze the period after the outbreak of the crisis in the Eurozone up today. More specifically, the period 2004-2016 is assessed. The empirical estimations are based on two-step generalized method of moments (GMM) transformed in first-differences in order to hand cross-section fixed effects. It seems that the effective corporate income tax rate is variously affected by firm-specific determining factors. More specifically, our empirical results indicate that the effective corporate income tax rate is negatively related to the firm size, capital intensity and return on assets. However, there is no statistically significant influence of financial leverage, inventory intensity, R&D intensity, participation of foreign investors to the equity ownership, participation of government to equity ownership, to the effective corporate income tax rate. Alternative estimation measures, as a robustness check, point out that the empirical findings are generally in agreement with the initial results.

This volume is the first systematic study of Seneca’s interaction with earlier literature of a variety of genres and traditions. It examines this interaction and engagement in his prose works, offering interpretative readings that are at once groundbreaking and stimulating to further study. Focusing on the Dialogues, the Naturales Quaestiones, and the Moral Epistles, the volume includes multi-perspectival studies of Seneca’s interaction with all the great Latin epics (Lucretius, Vergil and Ovid), and discussions of how Seneca’s philosophical thought is informed by Hellenistic doxography, forensic rhetoric and declamation, the Homeric tradition, Euripidean tragedy and Greco-Roman mythology. The studies analyzes the philosophy behind Seneca’s incorporating exact quotations from earlier tradition (including his criteria of selectivity) and Seneca’s interaction with ideas, trends and techniques from different sources, in order to elucidate his philosophical ideas and underscore his original contribution to the discussion of established philosophical traditions. They also provide a fresh interpretation of moral issues with particular application to the Roman worldview as fashioned by the mos maiorum. The volume, finally, features detailed discussion of the ways in which Seneca, the author of philosophical prose, puts forward his stance towards poetics and figures himself as a poet.

The aim of this paper is to examine the relationship between emotional intelligence and conflict resolution among secondary education teachers in Greece. The research sample consists of 130 high schools’ teachers in Greece. Data were collected using a structured questionnaire, concerning teachers’ working environment, their behavior during workplace conflicts as well as their emotional intelligence and were analyzed using descriptive and inductive statistics. The statistical analyses have revealed that the main reason for workplace conflicts in secondary schools is the existence of informal groups. In addition, emotional intelligence seem to have a direct relationship with conflict resolution styles, while a negative relationship between emotional intelligence and the frequency of involvement in workplace conflicts is observed. Furthermore, it was found that holding a position of responsibility does not play a significant role in conflict resolution style adoption. The research results show that the solution-oriented method is the most popular amongst the other conflict resolution styles. Last, it was found that the average score of emotional intelligence among the respondents was high.

Photovoltaic devices based on organic semiconductors and organo-metal halide perovskites have not yet reached the theoretically predicted power conversion efficiencies while they still exhibit poor environmental stability. Interfacial engineering using suitable materials has been recognized as an attractive approach to tackle the above issues. We introduce here a zinc porphyrin-triazine-bodipy donor-πbridge-acceptor dye as a universal electron transfer mediator in both organic and perovskite solar cells. Thanks to its "push-pull" character, this dye enhances electron transfer from the absorber layer toward the electron-selective contact, thus improving the device's photocurrent and efficiency. The direct result is more than 10% average power conversion efficiency enhancement in both fullerene-based (from 8.65 to 9.80%) and non-fullerene-based (from 7.71 to 8.73%) organic solar cells as well as in perovskite ones (from 14.56 to 15.67%), proving the universality of our approach. Concurrently, by forming a hydrophobic network on the surface of metal oxide substrates, it improves the nanomorphology of the photoactive overlayer and contributes to efficiency stabilization. The fabricated devices of both kinds preserved more than 85% of their efficiency upon exposure to ambient conditions for more than 600 h without any encapsulation. © 2019 American Chemical Society.

We downscaled a free ensemble of a regional, parent model to a high-resolution coastal, child ensemble in the Bay of Biscay. The child ensemble was forced at the open boundaries by the parent ensemble, and locally by perturbing the winds. By comparing ensembles generated by each of these forcing perturbations separately and combined we were able to consider the ensemble from either of two paradigms: (1) characterising high-resolution, coastal model errors using local and non-local forcing perturbations, or (2) downscaling regional model errors into the coastal domain. We found that most of the spread in the child ensembles was generated from the ensemble of open boundary conditions, with the local wind perturbations on their own generating substantially less ensemble spread. Together, the two sources of error increased the ensemble spread by only a small amount over the non-local perturbations alone. In general, the spread in sea surface height was greater in the child ensembles than in the parent ensemble, probably due to the more refined dynamics, while the spread in sea surface temperature was lower, likely due to the way the open boundary conditions were averaged. Deep below the surface, though, the child ensemble featured a large spread even where the parent model’s spread was very weak. This enhanced error response is a promising result for an ensemble data assimilation system, as it could be exploited to correct the model deep below the surface.

Ο Έρνστ Κασίρερ ανήκει σε εκείνους τους “παρεξηγημένους” σύγχρονους στοχαστές που το έργο τους διακόπηκε απότομα από τη λαίλαπα του φασισμού και του εθνικοσοσιαλισμού. Τις τελευταίες δεκαετίες παρατηρείται, ωστόσο, παγκοσμίως ένα ζωηρό ενδιαφέρον για το σύνολο του έργου του. Τούτο οφείλεται σε τρεις κυρίως λόγους: στις πολύ σημαντικές κοινωνικοπολιτικές του προεκτάσεις, στη διεπιστημονικότητα και στην οικουμενικότητα που το διέπει καθώς και στην εκ νέου ανακάλυψη της σημασίας και του επίκαιρου χαρακτήρα της θεωρίας του Κασίρερ περί μύθου. Στη Φιλοσοφία των συμβολικών μορφών ο Κασίρερ αποδίδει στο μύθο, όπως και στη γλώσσα, την ικανότητα να δομεί μέσω της χρήσης συμβόλων τον ανοίκειο “παθητικό κόσμο των απλών εντυπώσεων” και να τον μετατρέπει σε έναν κόσμο της “καθαρής πνευματικής έκφρασης”. Τούτη η συμβολοποιητική λειτουργία του ανθρώπινου πνεύματος δεν γίνεται αντιληπτή αλληγορικά. Αντιθέτως, ο νέος κόσμος του συμβόλου παρουσιάζεται στη συνείδηση ως “αντικειμενική” πραγματικότητα. Στην ιδιότητα αυτή του μύθου, στην πίστη στην αντικειμενική υπόσταση και στην αντικειμενική δύναμη του συμβόλου, έγκειται η ιδιαίτερη έλξη που ασκεί τούτος στον άνθρωπο ανά τους αιώνες, αλλά συνάμα και η επικινδυνότητά του.

This paper was published online on 12 December 2016 with an incorrect panel in Fig. 2. Figure 2 has been replaced as of 20 July 2020. The figure is incorrect in the printed version of the journal.

Cannabinoid administration during adolescence affects various physiological processes, such as motor and affective response, cognitive-related functions and modulates neurotransmitter activity. Literature remains scant concerning the parallel examination of the effects of adolescent escalating low-dose Δ(9) -tetrahydrocannabinol (Δ(9) -THC) on the behavioral and plasticity profile of adult rats in both sexes. Herein, we investigated the long-term behavioral, neurochemical and neurobiological effects of adolescent escalating low Δ(9) -THC doses in adult male and female rats. In adult males, adolescent low-dose Δ(9) -THC exposure led to increased spontaneous locomotor activity, impaired behavioral motor habituation and defective short-term spatial memory, paralleled with decreased BDNF protein levels in the prefrontal cortex. In this brain area, serotonergic activity was increased, as depicted by the increased serotonin turnover rate, while the opposite effect was observed in the hippocampus, a region where SERT levels were enhanced by Δ(9) -THC, compared with vehicle. In adult females, adolescent Δ(9) -THC treatment led to decreased spontaneous vertical activity and impaired short-term spatial memory, accompanied by increased BDNF protein levels in the prefrontal cortex. Present findings emphasize the key role of adolescent escalating low Δ(9) -THC exposure in the long-term regulation of motor response, spatial-related cognitive functions and neuroplasticity indices in adulthood. In this framework, these changes could, at a translational level, contribute to clinical issues suggesting the development of psychopathology in a sex-differentiated manner following Δ(9) -THC exposure during adolescence.

Unmanned Aircraft Systems (UAS) can be used to enhance monitoring of a wide range of environmental parameters, including acquiring data on various types of hydro-geomorphic phenomena. Their capabilities to provide on demand images and videos of high resolution, are particularly useful in the case of flash flood phenomena, which occur in spatial and temporal scales that do not favor traditional monitoring processes. In this work, flow velocity is estimated using aerial imaging acquired by means of an Unmanned Aircraft Vehicle (UAV) as well as ground observations during the catastrophic flash flood event of November 2017 in Mandra, Greece. In these imaging detailed tracing of various floating objects and particles such as light trash, debris etc. was carried out using multiple high-resolution video frames with specific time marks. Water velocity estimations were also cross-examined using flood mark-derived velocity hydraulic heads extracted by ground observations after the flood. The analysis was applied at a variety of locations across the study area, leading to a map of velocities for parts of the floodplain. Velocity values varied significantly depending on location, reaching up to 10m/s. The UAS proved to be very useful for the collection of important information for an extended area during the flood since a large portion of it was inaccessible due to road closures and safety issues. Nevertheless, the approach comes with certain limitations, including flight regulations, safety precautions and that rainfall is at a level that allows the deployment of a UAV during a flash flood. The findings show that the integration of aerial with ground observations in post-flood analysis contributes the completeness and accuracy of datasets regarding specific flash flood parameters and in the future could become a useful source of information, especially in data-poor regions.

The reaction of the uranium(III) complex [U(η8-Pn††)(η5-Cp*)] (1) (Pn†† = C8H4(1,4-SiiPr3)2, Cp∗ = C5Me5) with ethene at atmospheric pressure produces the ethene-bridged diuranium complex [{(η8-Pn††)(η5-Cp*)U}2(μ-η2:η2-C2H4)] (2). A computational analysis of 2 revealed that coordination of ethene to uranium reduces the carbon-carbon bond order from 2 to a value consistent with a single bond, with a concomitant change in the formal uranium oxidation state from +3 in 1 to +4 in 2. Furthermore, the uranium-ethene bonding in 2 is of the δtype, with the dominant uranium contribution being from f-d hybrid orbitals. Complex 2 reacts with hydrogen to produce ethane and reform 1, leading to the discovery that complex 1 also catalyzes the hydrogenation of ethene under ambient conditions.

The improvement of the accuracy of Structure-from-Motion photogrammetric products is discussed in this paper. In most cases it depends on the number and distribution of ground control points (GCPs) for block orientation, although the placement and precise measuring of GCPs are often time-consuming in a UAS project. This paper presents the evaluation of two approaches including Post Process Kinematic (PPK) and Network Real Time Kinematic (NRTK) methods aiming to avoid GCPs establishment, taking advantage of a real time positioning service, where differential corrections are sent from a network of Reference stations directly to the UAS.

BACKGROUND: Patients with body dysmorphic disorder (BDD) exhibit differential attentional mechanisms compared to healthy subjects. The exact nature of this differentiation is unclear. To this end, EEG (electrophysiological) responses to prepulse inhibition (PPI: reflecting attentional modulation) and prepulse facilitation (PPF: indicating orienting activation) were recorded and analysed. The aim of this study was to compare the respective neural oscillations associated with PPI and PPF in BDD vs healthy controls. MATERIALS AND METHODS: Event-related EEG oscillations elicited by PPI and PPF (26 and 25 trials, respectively, randomly presented) were explored in a sample of patients with BDD (N = 30) vs healthy controls (N = 25). The Yale-Brown Obsessive-Compulsive Scale for BDD (BDD-YBOCS), the Body Dysmorphic Disorder Examination, the Dysmorphic Concern Questionnaire (DCQ) and the Brown Assessment of Belief Scale (BABS) were also administered. RESULTS: Analysis of the power spectrum in response to PPI and PPF revealed that the BDD patient group compared to healthy controls exhibited higher theta-1 oscillations (potentially indicative of disrupted thalamo-cortical activation) and reduced beta-1 oscillations (potentially indicative of reduced top-down-controlled processing during attentional orienting). CONCLUSION: These findings offer novel contributions with regards to the neural mechanisms underlying attention processes in BDD patients, and demonstrate the potential of event-related EEG oscillations as a tool to better understand body dysmorphic disorder.

 

The evolution of eclipsing binaries leads towards angular momentum and mass loss from the systems, due to stellar wind and magnetic braking. Observational investigations of low-temperature and low-mass contact binaries (or LMCBs) in the solar neighborhood provide the means for studying a large sample of such systems. The observed orbital period cut-off limit of 0.22 days is believed to be a result of evolutionary mechanisms, and such systems act as probes in investigating the very evolved stages of systems before their final coalescence. The main goal of this study is the determination of the stellar evolution tracks of these type of LMCBs, which might be correlated to the formation of blue stragglers and rapidly rotating stars.

Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has resulted in hundreds of thousands of deaths worldwide. While the majority of people with COVID-19 won't require hospitalization, those who do may experience severe life-threatening complications, including acute respiratory distress syndrome. SARS-CoV-2 infects human cells by binding to the cellular surface protein angiotensin-converting enzyme 2 (ACE2); in addition, the cellular transmembrane serine protease 2 (TMPRSS2) is needed for priming of the spike (S) protein of the virus. Virus entry may also depend on the activity of the endosomal/lysosomal cysteine proteases cathepsin B, L (CTSB, CTSL) although their activity is likely dispensable. Given that the uncertainty of how COVID-19 kills, hampers doctors' ability to choose treatments the need for a deep understanding of COVID-19 biology is urgent. Herein, we performed an expression profiling meta-analysis of ACE2, TMPRSS2 and CTSB/L genes (and proteins) in public repository databases and found that all are widely expressed in human tissues; also, the ACE2 and TMPRSS2 genes tend to be co-regulated. The ACE2 and TMPRSS genes expression is (among others) suppressed by TNF, and is induced by pro-inflammatory conditions including obesity, Barrett's esophagus, stomach infection by helicobacter pylori, diabetes, autoimmune diseases and oxidized LDL; by exercise, as well as by growth factors, viruses' infections, cigarette smoke, interferons and androgens. Regarding currently investigated therapies interferon-beta induced ACE2 gene expression in bronchial epithelial cells, while chloroquine tends to upregulate CTSB/L genes. Finally, we analyzed KEGG pathways modulated by ACE2, TMPRSS2 and CTSB/L and probed DrugBank for drugs that target modules of the affected pathways. Our data indicate possible novel high-risk groups for COVID-19; provide a rich resource for future investigations of its pathogenesis and highlight the therapeutic challenges we face.

The field emission and resulting breakdown induced damage in the actuation paths of MEMS capacitive switches are investigated. The effect of asperities burning due to Joule heating and the resulting explosive break down are presented. The breakdown gives rise to almost mirror craters formation on the cathode and anode electrodes. A linear relation between crater diameter and the breakdown current is found when breakdown occurs in vacuum. In ambient atmosphere the breakdown leads to large amplitude current oscillations and the formation of extended damage on both electrodes. © 2020 Elsevier Ltd

1RXS J050526.3-684628 is a super soft source in the Large Magellanic Cloud(LMC). A recent study reported the discovery of coherent pulsations,and identified the system as an accreting White Dwarf (WD). Moreover, thestudy of historic X-ray and optical properties of J050526 have revealedit to be a remarkably long-lived post-nova SSS (~30 year duration),reaching its peak flux around 2013. Nevertheless, the lack of multipledeep X-ray observations hampers the study of the system and prohibitsfurther testing of theoretical models. We request a 60 ks XMM-Newtonobservation to study the evolution of its spectral and temporal propertiesduring the decay of its flux.

The COVID-19 pandemic has already had a shocking impact on the lives of everybody on the planet. Here, we present a modification of the classical SI model, the Fractal Kinetics SI model which is in excellent agreement with the disease outbreak data available from the World Health Organization. The fractal kinetic approach that we propose here originates from chemical kinetics and has successfully been used in the past to describe reaction dynamics when imperfect mixing and segregation of the reactants is important and affects the dynamics of the reaction. The model introduces a novel epidemiological parameter, the ``fractal{''} exponenthwhich is introduced in order to account for the self-organization of the societies against the pandemic through social distancing, lockdowns and flight restrictions.

BACKGROUND: A novel coronavirus (2019-nCoV) associated with human to human transmission and severe human infection has been recently reported from the city of Wuhan in China. Our objectives were to characterize the genetic relationships of the 2019-nCoV and to search for putative recombination within the subgenus of sarbecovirus. METHODS: Putative recombination was investigated by RDP4 and Simplot v3.5.1 and discordant phylogenetic clustering in individual genomic fragments was confirmed by phylogenetic analysis using maximum likelihood and Bayesian methods. RESULTS: Our analysis suggests that the 2019-nCoV although closely related to BatCoV RaTG13 sequence throughout the genome (sequence similarity 96.3%), shows discordant clustering with the Bat_SARS-like coronavirus sequences. Specifically, in the 5'-part spanning the first 11,498 nucleotides and the last 3'-part spanning 24,341-30,696 positions, 2019-nCoV and RaTG13 formed a single cluster with Bat_SARS-like coronavirus sequences, whereas in the middle region spanning the 3'-end of ORF1a, the ORF1b and almost half of the spike regions, 2019-nCoV and RaTG13 grouped in a separate distant lineage within the sarbecovirus branch. CONCLUSIONS: The levels of genetic similarity between the 2019-nCoV and RaTG13 suggest that the latter does not provide the exact variant that caused the outbreak in humans, but the hypothesis that 2019-nCoV has originated from bats is very likely. We show evidence that the novel coronavirus (2019-nCov) is not-mosaic consisting in almost half of its genome of a distinct lineage within the betacoronavirus. These genomic features and their potential association with virus characteristics and virulence in humans need further attention.

Context. Gaia Early Data Release 3 (Gaia EDR3) provides accurate astrometry for about 1.6 million compact (QSO-like) extragalactic sources, 1.2 million of which have the best-quality five-parameter astrometric solutions. Aims. The proper motions of QSO-like sources are used to reveal a systematic pattern due to the acceleration of the solar system barycentre with respect to the rest frame of the Universe. Apart from being an important scientific result by itself, the acceleration measured in this way is a good quality indicator of the Gaia astrometric solution. Methods. The effect of the acceleration is obtained as a part of the general expansion of the vector field of proper motions in Vector Spherical Harmonics (VSH). Various versions of the VSH fit and various subsets of the sources are tried and compared to get the most consistent result and a realistic estimate of its uncertainty. Additional tests with the Gaia astrometric solution are used to get a better idea on possible systematic errors in the estimate. Results. Our best estimate of the acceleration based on Gaia EDR3 is $(2.32 \pm 0.16) \times 10^{-10}$ m s${}^{-2}$ (or $7.33 \pm 0.51$ km s$^{-1}$ Myr${}^{-1}$) towards $\alpha = 269.1^\circ \pm 5.4^\circ$, $\delta = -31.6^\circ \pm 4.1^\circ$, corresponding to a proper motion amplitude of $5.05 \pm 0.35$ $\mu$as yr${}^{-1}$. This is in good agreement with the acceleration expected from current models of the Galactic gravitational potential. We expect that future Gaia data releases will provide estimates of the acceleration with uncertainties substantially below 0.1 $\mu$as yr${}^{-1}$.

We compare the Gaia DR2 and Gaia EDR3 performances in the study of the Magellanic Clouds and show the clear improvements in precision and accuracy in the new release. We also show that the systematics still present in the data make the determination of the 3D geometry of the LMC a difficult endeavour; this is at the very limit of the usefulness of the Gaia EDR3 astrometry, but it may become feasible with the use of additional external data. We derive radial and tangential velocity maps and global profiles for the LMC for the several subsamples we defined. To our knowledge, this is the first time that the two planar components of the ordered and random motions are derived for multiple stellar evolutionary phases in a galactic disc outside the Milky Way, showing the differences between younger and older phases. We also analyse the spatial structure and motions in the central region, the bar, and the disc, providing new insights into features and kinematics. Finally, we show that the Gaia EDR3 data allows clearly resolving the Magellanic Bridge, and we trace the density and velocity flow of the stars from the SMC towards the LMC not only globally, but also separately for young and evolved populations. This allows us to confirm an evolved population in the Bridge that is slightly shift from the younger population. Additionally, we were able to study the outskirts of both Magellanic Clouds, in which we detected some well-known features and indications of new ones.

We produce a clean and well-characterised catalogue of objects within 100\,pc of the Sun from the \G\ Early Data Release 3. We characterise the catalogue through comparisons to the full data release, external catalogues, and simulations. We carry out a first analysis of the science that is possible with this sample to demonstrate its potential and best practices for its use. The selection of objects within 100\,pc from the full catalogue used selected training sets, machine-learning procedures, astrometric quantities, and solution quality indicators to determine a probability that the astrometric solution is reliable. The training set construction exploited the astrometric data, quality flags, and external photometry. For all candidates we calculated distance posterior probability densities using Bayesian procedures and mock catalogues to define priors. Any object with reliable astrometry and a non-zero probability of being within 100\,pc is included in the catalogue. We have produced a catalogue of \NFINAL\ objects that we estimate contains at least 92\% of stars of stellar type M9 within 100\,pc of the Sun. We estimate that 9\% of the stars in this catalogue probably lie outside 100\,pc, but when the distance probability function is used, a correct treatment of this contamination is possible. We produced luminosity functions with a high signal-to-noise ratio for the main-sequence stars, giants, and white dwarfs. We examined in detail the Hyades cluster, the white dwarf population, and wide-binary systems and produced candidate lists for all three samples. We detected local manifestations of several streams, superclusters, and halo objects, in which we identified 12 members of \G\ Enceladus. We present the first direct parallaxes of five objects in multiple systems within 10\,pc of the Sun.

© Καμπερίδου, Ειρήνη (2020) Φύλο, Κοινωνικό Κεφάλαιο και Αθλητισμός: Από την έμφυλη κόπωση στην έμφυλη ενέργεια. Εισήγηση στο 7ο Τακτικό Συνέδριο της Ελληνικής Κοινωνιολογικής Εταιρείας (ΕΚΕ): Κοινωνίες μετά την κρίση, κοινωνίες χωρίς κρίση;  Αθήνα 23-25 Σεπτεμβρίου 2020, Ενότητα: Έμφυλες διακρίσεις στην κοινωνία, 24 Σεπτ. Βιβλίο Περιλήψεων/Περιλήψεις Εισηγήσεων, Τμήμα Επικοινωνίας και ΜΜΕ του Εθνικού και Καποδιστριακού Πανεπιστημίου Αθηνών (ΕΚΠΑ), σελ. 17. (http://www.hellenicsociology.gr/el/events). CITE AS: Καμπερίδου, Ειρήνη (2020). Φύλο, Κοινωνικό Κεφάλαιο και Αθλητισμός: Από την έμφυλη κόπωση στην έμφυλη ενέργεια (πρακτικά συνεδρίου). Πρακτικά Συνεδρίου Κοινωνίες μετά την κρίση, κοινωνίες χωρίς κρίση; Ενότητα: Έμφυλες διακρίσεις στην κοινωνία, 7ο Τακτικό Συνέδριο Ελληνικής Κοινωνιολογικής Εταιρείας (ΕΚΕ)-Hellenic Sociological Society (HSS), 23-25 Σεπτεμβρίου 2020:  περίληψη, σελ . 17. ΕΚΠΑ, ΤΜΗΜΑ ΕΠΙΚΟΙΝΩΝΙΑΣ ΚΑΙ ΜΜΕ. 

© Καμπερίδου, Ειρήνη (2020) Φύλο, Κοινωνικό Κεφάλαιο και Αθλητισμός: Από την έμφυλη κόπωση στην έμφυλη ενέργεια. Εισήγηση στο 7ο Τακτικό Συνέδριο της Ελληνικής Κοινωνιολογικής Εταιρείας (ΕΚΕ): Κοινωνίες μετά την κρίση, κοινωνίες χωρίς κρίση;  Αθήνα 23-25 Σεπτεμβρίου 2020, Ενότητα: Έμφυλες διακρίσεις στην κοινωνία, 24 Σεπτ. Βιβλίο Περιλήψεων/Περιλήψεις Εισηγήσεων, Τμήμα Επικοινωνίας και ΜΜΕ του Εθνικού και Καποδιστριακού Πανεπιστημίου Αθηνών (ΕΚΠΑ), σελ. 17. (http://www.hellenicsociology.gr/el/events).  

Women and US Politics: Historical and Contemporary Perspectives Essays in Honor of Hans-Jürgen Grabbe Julia Nitz (Hg.), Axel R. Schäfer (Hg.) ISBN: 978-3-8253-4648-5 Sortiment: BuchAusgabe: GebundenFachgebiet: Anglistik/AmerikanistikReihe: American Studies – A Monograph Series, Band: 303lieferbar: 23.10.2020 Schlagwörter: Amerikanistik, U.S.A., Politik, Frauenforschung, gender studies, Aktivismus, Feminismus, Gesellschaft, Suffragetten, Fernsehserien, Wharton, Edith, Kittredge, Charmian, Day, Dorothy, Arendt, Hannah, Mann, Sally, Wilson, Woodrow, Misogynie, Visual Studies, Politikgeschichte, Kulturwissenschaften, Clinton, Hillary, Medienwissenschaft, Obama, Michelle This collection maps the field of women and U.S. politics on the basis of leading international and interdisciplinary scholarship informed by political science, cultural studies, literary studies, history, and media studies. The volume focuses in particular on women’s political activism, how politics affects women, and the role of gender in politics.Recent research has called for an integrated interdisciplinary approach in analyzing women’s roles in U.S. politics, pointing out the shortcomings of earlier investigations, which mostly confined themselves to one subject area. Using this as a starting point, the volume features research that analyzes the agency women have possessed in the political sphere in the U.S. from various disciplinary perspectives. Its essays trace the role of women in U.S. politics from the Early Republic until today. Contributions include examinations of fictional and non-fictional negotiations of gendered politics in a range of media, as well as investigations of how U.S. politics past and present are conceptualized and practiced in relation to gender.

Presentation of antigenic peptides by MHCI is central to cellular immune responses against viral pathogens. While adaptive immune responses versus SARS-CoV-2 can be of critical importance to both recovery and vaccine efficacy, how protein antigens from this pathogen are processed to generate antigenic peptides is largely unknown. Here, we analyzed the proteolytic processing of overlapping precursor peptides spanning the entire sequence of the S1 spike glycoprotein of SARS-CoV-2, by three key enzymes that generate antigenic peptides, aminopeptidases ERAP1, ERAP2, and IRAP. All enzymes generated shorter peptides with sequences suitable for binding onto HLA alleles, but with distinct specificity fingerprints. ERAP1 was the most efficient in generating peptides 8-11 residues long, the optimal length for HLA binding, while IRAP was the least efficient. The combination of ERAP1 with ERAP2 greatly limited the variability of peptide sequences produced. Less than 7% of computationally predicted epitopes were found to be produced experimentally, suggesting that aminopeptidase processing may constitute a significant filter to epitope presentation. These experimentally generated putative epitopes could be prioritized for SARS-CoV-2 immunogenicity studies and vaccine design. We furthermore propose that this in vitro trimming approach could constitute a general filtering method to enhance the prediction robustness for viral antigenic epitopes.

The increasing use of the integrase strand transfer inhibitor (INSTI) class for the treatment of HIV-infection has pointed to the importance of analyzing the features of HIV-1 subtypes for an improved understanding of viral genetic variability in the occurrence of drug resistance (DR). In this study, we have described the prevalence of INSTI DR in a Russian cohort and the genetic features of HIV-1 integrase sub-subtype A6. We included 408 HIV infected patients who were not exposed to INSTI. Drug resistance mutations (DRMs) were detected among 1.3% of ART-naïve patients and among 2.7% of INSTI-naïve patients. The prevalence of 12 polymorphic mutations was significantly different between sub-subtypes A6 and A1. Analysis of the genetic barriers determined two positions in which subtype A (A1 and A6) showed a higher genetic barrier (G140C and V151I) compared with subtype B, and one position in which subtypes A1 and B displayed a higher genetic barrier (L74M and L74I) than sub-subtype A6. Additionally, we confirmed that the L74I mutation was selected at the early stage of the epidemic and subsequently spread as a founder effect in Russia. Our data have added to the overall understanding of the genetic features of sub-subtype A6 in the context of drug resistance.

The clinical course of prion diseases is accurately predictable despite long latency periods, suggesting that prion pathogenesis is driven by precisely timed molecular events. We constructed a searchable genome-wide atlas of mRNA abundance and splicing alterations during the course of disease in prion-inoculated mice. Prion infection induced PrP-dependent transient changes in mRNA abundance and processing already at eight weeks post inoculation, well ahead of any neuropathological and clinical signs. In contrast, microglia-enriched genes displayed an increase simultaneous with the appearance of clinical signs, whereas neuronal-enriched transcripts remained unchanged until the very terminal stage of disease. This suggests that glial pathophysiology, rather than neuronal demise, could be the final driver of disease. The administration of young plasma attenuated the occurrence of early mRNA abundance alterations and delayed signs in the terminal phase of the disease. The early onset of prion-induced molecular changes might thus point to novel biomarkers and potential interventional targets.

Achieving adequate micronutrient status, while avoiding deficiencies, represents a challenge for people globally. Consequently, many individuals resort to oral nutrient supplementation (ONS) in order to correct suboptimal dietary intakes. Advances in the fields of nutrigenetics and nutritional genomics have identified differences in response to micronutrient supplementation according to genetic makeup, adding dietary supplement use to the clinician's toolkit in the precision nutrition era. This review focuses on published evidence linking genetic variants to the responses associated with some of the most popular dietary supplements. With an increasing number of health professionals becoming involved in the prescription of ONS, identifying and matching individuals to the appropriate dietary supplement according to their genotype is important for achieving optimal health benefits and micronutrient equilibrium, while reducing the adverse events and financial costs often associated with excessive ONS.

Short-term property rentals are perhaps one of the most common traits of present day shared economy. Moreover, they are acknowledged as a major driving force behind changes in urban landscapes, ranging from established metropolises to developing townships, as well as a facilitator of geographical mobility. A geolocation ontology is a high level inference tool, typically represented as a labeled graph, for discovering latent patterns from a plethora of unstructured and multimodal data. In this work, a two-step methodological framework is proposed, where the results of various geolocation analyses, important in their own respect, such as ghost hotel discovery, form intermediate building blocks towards an enriched knowledge graph. The outlined methodology is validated upon data crawled from the Airbnb website and more specifically, on keywords extracted from comments made by users of the said platform. A rather solid case-study, based on the aforementioned type of data regarding Athens, Greece, is addressed in detail, studying the different degrees of expansion & prevalence of the phenomenon among the city’s various neighborhoods.

This paper examines the significance of 'geological argument' (age of earth, geological changes, stromatography, fossils) in the process of accepting the Theory of Evolution by Natural Selection (TENS), by Greek teachers that teach biology. It is a part of a wider research process, examining the conceptual ecology of evolution. That would be the most relevant terminology relating to the TENS (acceptance, understanding, opinions on the nature of science, way of thinking, religiosity) and their interconnectedness. The research was mainly quantitative, and it has been performed by the use of a closed-ended questionnaire. In addition, we used a qualitative methodology through semi-structured interviews, in order to deepen and interpret the findings of the quantitative method. The results show that there appears to occur an especially high acceptance of the TENS amongst geologists that teach biology in secondary education, compare to similar teachers of science. A finding that may lead to the conclusion that the "geological arguments" are especially strong in the process of accepting the TENS and suggest that they might, therefore, be used more often in the teaching of evolution.

This paper reviews the glacial history of the mountains of Greece at the southernmost tip of the Balkans, providing a new synthesis of our current understanding of glaciations. The ice cover during the largest Middle Pleistocene glaciations (MIS 12/MIS 6) was more extensive than previously thought. Latest evidence from Mt Chelmos suggests that valley glaciers radiated from a central plateau ice field, whereas the findings of other glacial studies in western Balkans further indicate that extensive ice field/ice caps formed on mountains throughout this region during the Middle Pleistocene glaciations. Ice extent was considerably smaller during the Tymphian Stage (MIS 5d–MIS 2) and this has been confirmed by cosmogenic exposure ages in recent studies on Mt Olympus and Mt Chelmos. During the Holocene, only very small glaciers formed in some deep cirques where they survived because of strong local topoclimatic controls. A comparative analysis with the findings of other glacial and palaeoclimatic studies in the Balkans is also presented to highlight correlations between them. Moisture supply seems to have been the most critical factor for the formation of glaciers in the mountains of Greece. The comparison of Late Pleistocene Equilibrium Line Altitudes (ELAs) across the Balkans indicates a wetter climate in southern Greece that can be attributed to different palaeoatmospheric circulation mechanisms and precipitation regime in central Mediterranean. Conclusively, whilst important information has been added in the last 2 decades, this paper highlights the need for further research in Greece and the wider Balkans to establish the timing and extent of glaciations.

Description of the spatial characteristics of viral dispersal is important in understanding the history of infections. Nine hepatitis B virus (HBV) genotypes (A-I), and a putative 10th genotype (J), with distinct geographical distribution, are recognized. In sub-Saharan Africa (sub)-genotypes A1, D3 and E circulate, with E predominating in western Africa (WA), where HBV is hyperendemic. The low genetic diversity of genotype E (HBV/E) suggests its recent emergence. Our aim was to study the dispersal of HBV/E using full-length, non-redundant and non-recombinant sequences available in public databases. HBV/E was confirmed, and the phylogeny reconstruction performed using maximum likelihood (ML) with bootstrapping. Phylogeographic analysis was conducted by reconstruction of ancestral states using the criterion of parsimony on the estimated ML phylogeny. 46.5% of HBV/E sequences were found within monophyletic clusters. Country-wise analysis revealed the existence of 50 regional clusters. Sequences from WA were located close to the root of the tree, indicating this region as the most probable origin of the HBV/E epidemic and expanded to other geographical regions, within and outside of Africa. A localized dispersal was observed with sequences from Nigeria and Guinea as compared to other WA countries. Based on the sequences available in the databases, the phylogenetic results suggest that European strains originated primarily from WA whereas a majority of American strains originated in Western Central Africa. The differences in regional dispersal patterns of HBV/E suggest limited cross-border transmissions because of restricted population movements.

Backround and Objective: We sought to assess in adult congenital heart disease (ACHD) patients the prognostic value of plasma galectin-3 (Gal-3) levels and systemic ventricular global longitudinal strain (SV GLS) as well as their association with NTproBNP and arrhythmogenesis. Materials and Methods: We studied 58 patients (26 men, mean age 37 +/- 16.8 years) with various congenital heart diseases. Patients underwent echocardiogram, 24 h ambulatory ECG monitoring, while NTproBNP and Gal-3 were measured. They were followed up (median of 790.5 days -IQR 350.3 days) and major cardiovascular events (MACE) were recorded. Results. Mean Gal-3 levels were 17.07 +/- 6.38 ng/m. Plasma Gal-3 was correlated with LogNTproBNP (r = 0.456, p = 0.001).Gal-3 levels associated with supraventricular tachycardia (SVT) (p < 0.001) and ventricular tachycardia (VT) (p < 0.001), but was not associated with MACE (HR 1.018, 95% CI 0.944-1.098, p = 0.641).Mean SVGLS in patients with systemic left ventricle was -15.91% +/- 4.09%, which was significantly lower compared to patients with systemic right ventricle and patients with single ventricle (-11.42% +/- 3.37% and -11.9% +/- 5.06%, respectively, p = 0.021).SV GLS correlated with plasma Gal-3 (r = 0.313, p = 0.027) and logNTproBNP (r = 0.479, p < 0.001). SVGLS correlated with VT arrhythmias (p = 0.004). NTproBNP predicted MACE (AUC 0.750, p = 0.03). SVGLS also predicted MACE (AUC 0.745, p = 0.03. In multivariate analysis, SVGLS and logNTproBNP maintained their predictive value (p = 0.004 and p = 0.009, respectively) Conclusion: In ACHD patients, SV GLS was found to predict MACE independently from NTproBNP and correlated with VT. Gal-3 correlated with NTproBNP and SVGLS as well as SVT and VT, but has not been shown to bear significant prognostic potential

In this study, (E)-2-cyano-3-(6-(dimethylamino)naphthalen-2-yl)-N-(β-d-glucopyranosyl)acrylamide, a β-d-glucopyranosyl analogue of the widely used molecular rotor julolidine, was synthesized and studied photochemically. The new compound is a fluorescent inhibitor of rabbit muscle glycogen phosphorylase with properties of a molecular rotor. Fluorescence measurements in solutions of increasing viscosity determined that the fluorescence intensity increases with the viscosity of the medium, indicating that the new compound exhibits molecular rotor characteristics. Although the compound fluoresces negligibly in an aqueous buffer solution, in the presence of increasing amounts of rabbit muscle glycogen phosphorylase, we observed an increase in fluorescence intensity, which was attributed to the formation of an inhibitor–enzyme complex. In-vitro cellular studies were also undertaken, yielding promising preliminary results for the use of the new compound as a fluorescent probe.

Cortical development is a very complex process in which any temporal or spatial alterations can give rise to a wide range of cortical malformations. Among those malformations, periventricular heterotopia (PH) is characterized by clusters of neurons that do not migrate to the correct place. Cerebral organoids derived from patients with mutations in DCHS1 and FAT4, which have been associated with PH, exhibit higher levels of GNG5 expression in a patient-specific cluster of neurons. Here we investigate the role of GNG5 during the development of the cerebral cortex in mice and human cerebral organoids. GNG5, highly expressed in progenitors and downregulated in neurons, is critical for controlling the number of apical and basal progenitors and neuronal migration. Moreover, forced expression of GNG5 recapitulates some of the alterations observed upon downregulation of Dchs1 and Fat4 in mice and human cerebral organoids derived from DCHS1 and FAT4 patients, suggesting a critical role of GNG5 in cortical development.

Photonic crystal structuring has emerged as an advanced method to enhance solar light harvesting by metal oxide photocatalysts along with rational compositional modifications of the materials’ properties. In this work, surface functionalization of TiO2 photonic crystals by blue luminescent graphene quantum dots (GQDs), n–π* band at ca. 350 nm, is demonstrated as a facile, environmental benign method to promote photocatalytic activity by the combination of slow photon-assisted light trapping with GQD-TiO2 interfacial electron transfer. TiO2 inverse opal films fabricated by the co-assembly of polymer colloidal spheres with a hydrolyzed titania precursor were post-modified by impregnation in aqueous GQDs suspension without any structural distortion. Photonic band gap engineering by varying the inverse opal macropore size resulted in selective performance enhancement for both salicylic acid photocatalytic degradation and photocurrent generation under UV–VIS and visible light, when red-edge slow photons overlapped with the composite’s absorption edge, whereas stop band reflection was attenuated by the strong UVA absorbance of the GQD-TiO2 photonic films. Photoelectrochemical and photoluminescence measurements indicated that the observed improvement, which surpassed similarly modified benchmark mesoporous P25 TiO2 films, was further assisted by GQDs electron acceptor action and visible light activation to a lesser extent, leading to highly efficient photocatalytic films. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.

Photonic crystal structuring has emerged as an advanced method to enhance solar light harvesting by metal oxide photocatalysts along with rational compositional modifications of the materials’ properties. In this work, surface functionalization of TiO2 photonic crystals by blue luminescent graphene quantum dots (GQDs), n–π* band at ca. 350 nm, is demonstrated as a facile, environmental benign method to promote photocatalytic activity by the combination of slow photon-assisted light trapping with GQD-TiO2 interfacial electron transfer. TiO2 inverse opal films fabricated by the co-assembly of polymer colloidal spheres with a hydrolyzed titania precursor were post-modified by impregnation in aqueous GQDs suspension without any structural distortion. Photonic band gap engineering by varying the inverse opal macropore size resulted in selective performance enhancement for both salicylic acid photocatalytic degradation and photocurrent generation under UV–VIS and visible light, when red-edge slow photons overlapped with the composite’s absorption edge, whereas stop band reflection was attenuated by the strong UVA absorbance of the GQD-TiO2 photonic films. Photoelectrochemical and photoluminescence measurements indicated that the observed improvement, which surpassed similarly modified benchmark mesoporous P25 TiO2 films, was further assisted by GQDs electron acceptor action and visible light activation to a lesser extent, leading to highly efficient photocatalytic films. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.

In the current study, the challenges, the priorities and the systemic opportunitiesregarding Greece’s strategic behavior and its overall policy initiatives in the Aegean in the post-Cold War era are described and analyzed. In accordance with the Dardanelles Strait, the Aegean Sea represents an integral part of a trade passage of great significance for the regional balance of power, as well as for the planet-level effects on the balance of power among the Great Powers.Hence, the strategic behavior of the littoral states - Greece and Turkey - owns distinctive value for the geopolitics of the Greater Middle East, especially in the aftermath of the end of the bipolar order of the international system. This is examined in the light of the questions above: What are the static geopolitical aspects determining the balance of power in the Aegean Sea and what are the new challenges of the post-Cold War system?What are the political-strategic initiatives taken by Greece and what is the level of effectiveness within the framework of national interest implementation?The crux of the matter relates to the great geopolitical significance of the trade sea passage of Dardanelles-Aegean and the position of the intervening actors on the climax of power not permitting them to act as the sole geopolitical factors. This is implemented by the super-systemic actors and of course, the dominating naval powers, as it was the case of the U.S. in the post-war era. Nevertheless, the strategy of small and middle powers may give answers to such challenges when leadership capacity and strategic plans will exist in an active way vis-à-vis the inter-state dilemmas, especially when referring to Greece owning - according to the International Law of Seas - the dominant role in the Aegean Sea.For instance, the plan and implementation of patron-client relations could contribute productively towards this aim via the interconnection of interests and the cultivation of a situation of mutual commitment between the dominating naval power and Athens. On the contrary, the failure of Greece to move towards this choice deals with the overall failure of Greece’s strategy in the Aegean Sea in the post-Cold era, referring to deterrence credibility, managing security dilemmas and last but not least, balancing the Turkish threat.

This paper is a qualitative study in the framework of a broader project (LETEGR2) that aims to shed light on the way classroom-based observation might contribute to bridging the gap between teaching theory and practice and assisting teacher education. It draws on data derived from pre-service (n=15) and in-service teachers (n=6) who applied the LETEGR2 Classroom Observation protocol in second language classrooms in Greece. Both groups of data are presented according to the observation stages (pre- and post-) in which they have been collected. They are discussed as pre- and in-service teachers’ “voices” in terms of the main issues they bring to the fore in relation to L2 learners’ profiles, the teaching process and teachers’ practices. An attempt is made to link both group of participants’ observed behaviours and events to underlying theoretical concepts for second language learning and teaching.

During the last few years, olive oil quality and adulteration control has increased since it is of great importance to consumers, suppliers and retailers. Different analytical methods and parameters combined with statistical methods are used to detect the authenticity and adulteration of extra virgin oil in a global Foodomics approach. In the present chapter, the application of different analytical techniques and chemometrics for the determination of extra virgin olive oil authenticity including adulteration are discussed. Finally, the latest trends on analytical approaches to assess the olive oil geographical and varietal origin traceability are also examined.

Small heat shock proteins (sHSPs) participate in numerous cellular functions including cell signaling, differentiation, and apoptosis. Deregulation of the physiological expression level of sHSPs has been associated with several malignancies. Heat shock protein beta 3 (HSPB3) is the third member of the sHSP family in human and is mainly expressed in skeletal and smooth muscles. In this study, we investigated the potential prognostic significance of HSPB3 expression in colorectal adenocarcinoma, the most frequent type of colorectal cancer. For this purpose, we isolated total RNA from 188 colorectal adenocarcinoma specimens and 68 paired noncancerous ones. After reverse transcription of 2 $μ$g total RNA, we quantified HSPB3 levels by using an in-house–developed real-time quantitative polymerase chain reaction method, based on the SYBR Green chemistry. Comparison of HSPB3 levels among 68 pairs of colorectal tumors and their adjacent noncancerous mucosae uncovered the downregulation of HSPB3 expression in the majority of malignant colorectal tumors. More importantly, high HSPB3 expression is associated with poor relapse-free survival (RFS) and overall survival (OS) of patients with colorectal adenocarcinoma. Multivariable Cox regression analysis revealed that HSPB3 overexpression could serve as an adverse prognostic biomarker in colorectal adenocarcinoma, independent of tumor location, histological grade, and TNM stage. Patients' stratification according to tumor location, histological grade, and TNM stage revealed that high HSPB3 messenger RNA expression retains its unfavorable prognostic potential regarding OS, in particular groups of patients with substantially different prognosis. In conclusion, high HSPB3 expression is associated with poor RFS and OS of patients with colorectal adenocarcioma, independently of clinicopathological prognosticators.

Dual-modality contrast agents (DMCA), such as radiolabeled magnetic nanoparticles, have attracted significant attention in diagnostic applications due to their potency for the timely and accurate diagnosis of diseases. The hemocompatibility of a candidate DMCA with human blood is essential for the investigation of its application in vivo. In this respect, here we focused on the evaluation of the hemocompatibility of a new DMCA, that is based on iron oxide nanoparticles (i.e. Fe3O4 magnetite), with human red blood cells (RBCs). The specific iron oxide nanoparticles are surface functionalized with 2,3-dicarboxypropane-1,1-diphosphonic acid (-DPD) and radiolabeled with gallium-68 (Ga-68), resulting in Ga-68-DPD-Fe3O4. RBCs of five healthy individuals are incubated at room temperature for 120 min without and with Ga-68-DPD-Fe3O4 at concentrations 0.1 and 1.0 mg/ml. Optical microscopy (OM) and atomic force microscopy (AFM) are employed to assess detailed information on the overall morphological and geometrical characteristics of the entire cell at the microscopic (10(-6) m) level and on the membrane morphology at the nanoscopic (10(-9) m) level. In addition, a standard hematology analyzer (HA) is used to obtain complete blood count information. At the microscopic level, the combined OM, AFM and HA data revealed that the overall shape/size characteristics of RBCs were preserved upon incubation with Ga-68-DPD-Fe3O4 . However, at the nanoscopic level, the AFM results revealed two different kinds of local deconstructions of the RBCs membrane, termed holes and ulcerlike abnormalities, that were observed in both the DMCA-free and DMCA-incubated samples. Holes did not exhibit any statistically significant difference upon incubation with the Ga-68-DPD-Fe3O4 DMCA. On the contrary, ulcer-like abnormalities exhibited two statistically significant differences upon incubation with the Ga-68-DPD-Fe3O4 DMCA. First, increased percentage of RBCs having at least one ulcer-like abnormality; in DMCA-incubated samples 78.6 +/- 11.6% for C-DMCA = 0.1 mg/ml and 80.4 +/- 11.1% for C-DMCA = 1.0 mg/ml, while in DMCA-free samples 61.2 +/- 8.4% prior to and 63.6 +/- 13.5% after incubation. Second, increased number of ulcer-like abnormalities per RBC; in DMCA-incubated samples 4.26 +/- 0.62 for C-DMCA = 0.1 mg/ml and 3.99 +/- 0.97 for C-DMCA = 1.0 mg/ml, while in DMCA-free samples 2.84 +/- 0.54 prior to and 2.98 +/- 0.50 after incubation. The combined OM, AFM and HA results prove fair hemocompatibility of the Ga-68-DPD-Fe3O4 DMCA with human RBCs, thus documenting its potential use in imaging applications.

BACKGROUND & AIMS: Hepatocellular carcinoma (HCC) may develop in chronic hepatitis (CHB) patients even after 5 years of oral therapy and cannot be easily predicted. We assessed predictors and need for HCC surveillance in this setting. METHODS: Of 1951 adult Caucasians with CHB included in the PAGE-B cohort, 1427 (73%) have completed follow-up >5 years under therapy without HCC until year 5. Median follow-up has been 8.4 years from treatment onset. Points-based risk scores were developed to predict HCC risk after year 5. RESULTS: In years 5-12, HCC has been diagnosed in 33/1427 (2.3%) patients with cumulative incidence 2.4%, 3.2% and 3.8% at 8, 10 and 12 years, respectively. Older age or age >50 years, baseline cirrhosis and liver stiffness (LSM) >/=12 kPa at year 5 were independently associated with increased HCC risk. The HCC incidence was lower in non-cirrhotics than those with baseline cirrhosis and year-5 LSM <12 kPa than those with baseline cirrhosis and year-5 LSM >/=12 kPa. CAGE-B score was based on age at year 5 and baseline cirrhosis in relation to LSM at year 5 and SAGE-B score was based only on age and LSM at year 5 (c-index=0.809-0.814, 0.805-0.806 after bootstrap validation). Both scores offered 100% negative predictive values for HCC development in their low risk groups. CONCLUSIONS: In Caucasians with CHB, the HCC risk after the first 5 years of antiviral therapy depends on age, baseline cirrhosis status and LSM at year 5. CAGE-B and particularly SAGE-B represent simple and reliable risk scores for HCC prediction and surveillance beyond year 5 of therapy.

Heterostructured bilayer films, consisting of co-assembled TiO2 photonic crystals as the bottom layer and a highly performing mesoporous P25 titania as the top layer decorated with CoOx nanoclusters, are demonstrated as highly efficient visible-light photocatalysts. Broadband visible-light activation of the bilayer films was implemented by the surface modification of both titania layers with nanoscale clusters of Co oxides relying on the chemisorption of Co acetylacetonate complexes on TiO2, followed by post-calcination. Tuning the slow photon regions of the inverse opal supporting layer to the visible-light absorption of surface CoOx oxides resulted in significant amplification of salicylic-acid photodegradation under visible and ultraviolet (UV)–visible light (Vis), outperforming benchmark P25 films of higher titania loading. This enhancement was related to the spatially separated contributions of slow photon propagation in the inverse opal support layer assisted by Bragg reflection toward the CoOx-modified mesoporous P25 top layer. This effect indicates that photonic crystals may be highly effective as both photocatalytically active and backscattering layers in multilayer photocatalytic films. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.

Objectives: Clusterin (CLU) is a multifunctional intra-/extra-cellular molecular chaperone with indications of serving as a promising prognostic biomarker for colorectal cancer (CRC). Several studies have examined the potential prognostic value of the CLU protein in CRC; however, our research follows an alternative approach, focusing on the CLU mRNA expression. Design and methods: Total RNA from 172 cancerous tissue specimens and 39 paired non-cancerous ones was isolated and 2 $μ$g of this were subjected to reverse transcription with an oligo-dT primer. The single stranded DNA, which was synthesized, was amplified with an in-house developed highly sensitive and precise qPCR method, using specific pair of primers for the CLU molecule. Finally, an extensive biostatistical analysis took place for the assessment of the results. Results: Patients with tumors expressing high CLU mRNA levels had a higher probability for poor outcome (relapse and death), comparing to those with CLU mRNA-negative tumors. This association between CLU mRNA expression status and both disease-free survival (DFS) and overall survival (OS) is evident in Cox regression analysis and is also depicted in the Kaplan-Meier survival curves. Consistently, the aforementioned associations and the CLU mRNA expression levels are significantly enhanced as CRC tumors progress from TNM stage I to IV, further supporting the functional implication of CLU in tumorigenesis. Conclusions: High CLU mRNA levels in CRC tumors can act as a new adverse prognostic biomarker of DFS and OS for CRC, independent of clinicopathological and biological features of the patient.

Remote sensing techniques and laser scanning technology have given us the opportunity to study indoor environments, such as caves, with their complex and unique morphology. In the presented case study, we used a handheld laser scanner for acquiring points with projected coordinate information (X, Y, Z) covering the entire show cave of Koutouki; including its hidden passages and dark corners. The point cloud covers the floor, the walls, and the roof of the cave, as well as the stalactites, stalagmites and the connected columns that constitute the decoration of the cave. The absolute and exact placement of the point cloud within a geographic reference frame gives us the opportunity for three-dimensional measurements and detailed visualization of the subsurface structures. Using open - source software, we managed to make a quantification analysis of the terrain and generated morphological and geometric features of the speleothems. We identified 55 columns by using digital terrain analysis and processed them statistically in order to correlate them to the frame of the cave development. The parameters that derived are the contours, each column height, the speleothem geometry and volume, as well as the volume of the open space cavity. We argue that by the demonstrated methodology, it is possible to identify with high accuracy and detail: the geomorphological features of a cave, an estimate of the speleogenesis, and the ability to monitor the evolution of a karstic system.

Tidal disruption events (TDE) have been considered as cosmic-ray and neutrino sources for a decade. We suggest two classes of new scenarios for high-energy multi-messenger emission from TDEs that do not have to harbor powerful jets. First, we investigate high-energy neutrino and gamma-ray production in the core region of a supermassive black hole. In particular, we show that ∼1-100 TeV neutrinos and MeV gamma rays can efficiently be produced in hot coronae around an accretion disk. We also study the consequences of particle acceleration in radiatively inefficient accretion flows (RIAFs). Second, we consider possible cosmic-ray acceleration by sub-relativistic disk-driven winds or interactions between tidal streams, and show that subsequent hadronuclear and photohadronic interactions inside the TDE debris lead to GeV-PeV neutrinos and sub-GeV cascade gamma rays. We demonstrate that these models should be accompanied by soft gamma rays or hard X-rays as well as optical/UV emission, which can be used for future observational tests. Although this work aims to present models of non-jetted high-energy emission, we discuss the implications of the TDE AT2019dsg that might coincide with the high-energy neutrino IceCube-191001A, by considering the corona, RIAF, hidden sub-relativistic wind, and hidden jet models. It is not yet possible to be conclusive about their physical association and the expected number of neutrinos is typically much less than unity. We find that the most optimistic cases of the corona and hidden wind models could be consistent with the observation of IceCube-191001A, whereas jet models are unlikely to explain the multi-messenger observations.

The goal of this study is to create a high-resolution grid of precipitation indices for the wider Greek region using real data from meteorological stations for the 1980-2010 period. Under the risk of increased extreme events caused by climate change, it is important to be able to have a high-resolution gridded extreme precipitation indices in order to overcome the lack of density of observations in both time and space. The development of such a grid can be used to validate model outputs and inform decision makers to better mitigate the damage from extreme precipitation. The first step of the analysis is to calculate the extreme precipitation indices based on daily observations derived from more than 100 meteorological stations covering a wide range of altitudes and spatial climate patterns existing in Greece. Thereafter, the extreme indices will be multilinearly downscaled to a 12-meter resolution grid. The geophysical parameters used in the downscaling procedure consists of altitude, latitude, longitude, slope, aspect, solar irradiance and Euclidian distance from the water bodies. The altitude information came from the highly accurate 12-meter resolution TanDEM-X Elevation Model, which is a product generated from the TerraSAR-X satellite mission data. The resulting high-resolution patterns will give insight of the spatial and temporal variability of extreme precipitation, over the complex terrain of the wider Greek region.

BACKGROUND: Aristotle was a seek-test-treat intervention during an outbreak of human immunodeficiency virus (HIV) infection among people who inject drugs (PWID) in Athens, Greece that started in 2011. The aims of this analysis were: (1) to study changes of drug injection-related and sexual behaviors over the course of Aristotle; and (2) to compare the likelihood of risky behaviors among PWID who were aware and unaware of their HIV status. METHODS: Aristotle (2012-2013) involved five successive respondent-driven sampling rounds of approximately 1400 PWID each; eligible PWID could participate in multiple rounds. Participants were interviewed using a questionnaire, were tested for HIV, and were classified as HIV-positive aware of their status (AHS), HIV-positive unaware of their status (UHS), and HIV-negative. Piecewise linear generalized estimating equation models were used to regress repeatedly measured binary outcomes (high-risk behaviors) against covariates. RESULTS: Aristotle recruited 3320 PWID (84.5% males, median age 34.2 years). Overall, 7110 interviews and blood samples were collected. The proportion of HIV-positive first-time participants who were aware of their HIV infection increased from 21.8% in round A to 36.4% in the last round. The odds of dividing drugs at least half of the time in the past 12 months with a syringe someone else had already used fell from round A to B by 90% [Odds Ratio (OR) (95% Confidence Interval-CI): 0.10 (0.04, 0.23)] among AHS and by 63% among UHS [OR (95% CI): 0.37 (0.19, 0.72)]. This drop was significantly larger (p = 0.02) among AHS. There were also decreases in frequency of injection and in receptive syringe sharing in the past 12 months but they were not significantly different between AHS (66 and 47%, respectively) and UHS (63 and 33%, respectively). Condom use increased only among male AHS from round B to the last round [OR (95% CI): 1.24 (1.01, 1.52)]. CONCLUSIONS: The prevalence of risky behaviors related to drug injection decreased in the context of Aristotle. Knowledge of HIV infection was associated with safer drug injection-related behaviors among PWID. This highlights the need for comprehensive interventions that scale-up HIV testing and help PWID become aware of their HIV status.

Summary During 2011–16, HIV outbreaks occurred among people who inject drugs (PWID) in Canada (southeastern Saskatchewan), Greece (Athens), Ireland (Dublin), Israel (Tel Aviv), Luxembourg, Romania (Bucharest), Scotland (Glasgow), and USA (Scott County, Indiana). Factors common to many of these outbreaks included community economic problems, homelessness, and changes in drug injection patterns. The outbreaks differed in size (from under 100 to over 1000 newly reported HIV cases among PWID) and in the extent to which combined prevention had been implemented before, during, and after the outbreaks. Countries need to ensure high coverage of HIV prevention services and coverage higher than the current UNAIDS recommendation might be needed in areas in which short acting drugs are injected. In addition, monitoring of PWID with special attention for changing drug use patterns, risk behaviours, and susceptible subgroups (eg, PWID experiencing homelessness) needs to be in place to prevent or rapidly detect and contain new HIV outbreaks.

We study hole transfer in open cumulenic and polyynic nanowires made of N carbon atoms, using real-time time-dependent density functional theory (RT-TDDFT) and tight-binding (TB) wire models. For RT-TDDFT, we mainly use functional B3LYP and basis sets cc-pVDZ, cc-pVTZ, and cc-pVQZ, obtaining clear convergence; cc-pVTZ is the smallest basis set of sufficient quality; cc-pVQZ is better with a higher computational cost. For TB, we use a simplistic wire model where all sites are equivalent (TBI) and models with modified initial and final sites, mimicking the existence of one or two or three hydrogens at edge sites (TBImod, TBImodt4times). We compare the ground state energy, EGS, obtained by density functional theory (DFT) for cumulenic molecules with coplanar (co) or perpendicular (pe) methylene end groups as well as polyynic molecules starting with short (sl) or with long (ls) C–C bonds. For odd N, cumulenic pe molecules have lower EGS than cumulenic co molecules, that are probably transition states. We examine energy spectra, density of states, energy gap, charge oscillations, mean over time probabilities to find the hole at each site, coherent transfer rates, electric dipole moment, and frequency content. DFT shows that due to the impact of end groups, there exists a cumulenic energy gap, smaller than the polyynic one. TBI and TBImod reproduce approximately the magnitude of the energy gap in the polyynic case at the limit of large N. TBImod is capable of predicting the same site occupations with the nicely converged RT-TDDFT ones for the cumulenic case. However, charge and dipole moment oscillations as well as transfer rates by RT-TDDFT are approximately four times faster than those by TBImod. The site occupations of polyynic sl and of polyynic ls molecules are modified relative to cumulenic molecules; the trends can be explained qualitatively.

We investigate hole transfer in open carbynes, i.e., carbon atomic nanowires, using Real-Time Time-Dependent Density Functional Theory (RT-TDDFT). The nanowire is made of N carbon atoms. We use the functional B3LYP and the basis sets 3-21G, 6-31G*, cc-pVDZ, cc-pVTZ, cc-pVQZ. We also utilize a few Tight-Binding (TB) wire models, a very simple model with all sites equivalent and transfer integrals given by the Harrison pp&#x3C0;">ppπ expression (TBI) as well as a model with modified initial and final sites (TBImod) to take into account the presence of one or two or three hydrogen atoms at the edge sites. To achieve similar site occupations in cumulenes with those obtained by converged RT-TDDFT, TBImod is sufficient. However, to achieve similar frequency content of charge and dipole moment oscillations and similar coherent transfer rates, the TBImod transfer integrals have to be multiplied by a factor of four (TBImodt4times). An explanation for this is given. Full geometry optimization at the B3LYP/6-31G* level of theory shows that in cumulenes bond length alternation (BLA) is not strictly zero and is not constant, although it is symmetrical relative to the molecule center. BLA in cumulenic cases is much smaller than in polyynic cases, so, although not strictly, the separation to cumulenes and polyynes, approximately, holds. Vibrational analysis confirms that for N even all cumulenes with coplanar methylene end groups are stable, for N odd all cumulenes with perpendicular methylene end groups are stable, and the number of hydrogen atoms at the end groups is clearly seen in all cumulenic and polyynic cases. We calculate and discuss the Density Functional Theory (DFT) ground state energy of neutral molecules, the CDFT (Constrained DFT) “ground state energy” of molecules with a hole at one end group, energy spectra, density of states, energy gap, charge and dipole moment oscillations, mean over time probabilities to find the hole at each site, coherent transfer rates, and frequency content, in general. We also compare RT-TDDFT with TB results.

Across time and place, right hand preference has been the norm, but what is the precise prevalence of left- and right-handedness? Frequency of left-handedness has shaped and underpinned different fields of research, from cognitive neuroscience to human evolution, but reliable distributional estimates are still lacking. While hundreds of empirical studies have assessed handedness, a large-scale, comprehensive review of the prevalence of handedness and the factors which moderate it, is currently missing. Here, we report five meta-analyses  on hand preference for different manual tasks and show that left-handedness prevalence lies between 9.34% (using the most stringent criterion of left-handedness) to 18.1% (using the most lenient criterion of non-right-handedness), with the best overall estimate being 10.6% (10.4% when excluding studies assessing elite athletes’ handedness). Handedness variability depends on (a) study characteristics, namely year of publication and ways to measure and classify handedness, and (b) participant characteristics, namely sex and ancestry. Our analysis identifies the role of moderators which require taking into account in future studies on handedness and hemispheric asymmetries. We argue that the same evolutionary mechanisms should apply across geographical regions to maintain the roughly 1:10 ratio, while cultural factors, such as pressure against left-hand use, moderate the magnitude of the prevalence of left-handedness. Although handedness appears as a straightforward trait, there is no universal agreement on how to assess it. Therefore, we urge researchers to fully report study and participant characteristics as well as the detailed procedure by which handedness was assessed and make raw data publicly available.

The impact of tides on the Bay of Biscay dynamics is investigated by means of an ocean model twin-experiment, consisted of two simulations with and without tidal forcing. The study is based on a high-resolution (1/36∘) regional configuration of NEMO (Nucleus for European Modelling of the Ocean) performing one-year simulations. The results highlight the imprint of tides on the thermohaline properties and circulation patterns in three distinct dynamical areas in the model domain: the abyssal plain, the Armorican shelf and the English Channel. When tides are activated, the bottom stress is increased in the shelf areas by about two orders of magnitude with respect to the open ocean, subsequently enhancing vertical mixing and weakening stratification in the bottom boundary layer. The most prominent feature reproduced only when tides are modelled, is the Ushant front near the entrance of the English Channel. Tides appear also to constrain the freshwater transport of rivers from the continental shelf to the open ocean. The spectral analysis revealed that the tidal forcing contributes to the SSH variance at high frequencies near the semidiurnal band and to the open ocean mesoscale and small-scale features in the presence of summer stratification pattern.

An in situ electrochemical electron paramagnetic resonance (EPR) spectroscopic study of N-doped reduced graphene oxide (N-rGO) is reported with the aim of understanding the properties of this material when employed as an electrical double-layer capacitor. N-rGO shows a capacitance of 100 F g−1 in 6 M KOH, which is twice that found for reduced graphene oxide (rGO). The temperature dependence of the rGO EPR signal revealed two different components: a narrow component, following the Curie law, was related to defects; and a broad curve with a stronger Pauli law component was attributed to the spin interaction between mobile electrons and localised π electrons trapped at a more extended aromatic structure. The N-rGO sample presented broader EPR signals, indicative of additional contributions to the resonance width. In situ EPR electrochemical spectroscopy was applied to both samples to relate changes in unpaired electron density to the enhanced capacitance. The narrow and broad components increased and diminished reversibly with potential. The potential-dependent narrow feature was related to the generated radical species from corresponding functional groups: e.g. O- and N-centred radicals. Improved capacitance seen for the N-modified basal graphene planes can be accordingly suggested to underlie the enhanced capacitance of N-rGO in basic electrolytes. © 2020 The Authors

In autosomal dominant optic atrophy (ADOA), caused by mutations in the mitochondrial cristae biogenesis and fusion protein optic atrophy 1 (Opa1), retinal ganglion cell (RGC) dysfunction and visual loss occur by unknown mechanisms. Here, we show a role for autophagy in ADOA pathogenesis. In RGCs expressing mutated Opa1, active 5' AMP-activated protein kinase (AMPK) and its autophagy effector ULK1 accumulate at axonal hillocks. This AMPK activation triggers localized hillock autophagosome accumulation and mitophagy, ultimately resulting in reduced axonal mitochondrial content that is restored by genetic inhibition of AMPK and autophagy. In C. elegans, deletion of AMPK or of key autophagy and mitophagy genes normalizes the axonal mitochondrial content that is reduced upon mitochondrial dysfunction. In conditional, RGC specific Opa1-deficient mice, depletion of the essential autophagy gene Atg7 normalizes the excess autophagy and corrects the visual defects caused by Opa1 ablation. Thus, our data identify AMPK and autophagy as targetable components of ADOA pathogenesis.

Considering the global climate change and the ensuing sea level rise, the subsequent acceleration of coastal erosion is evident. Phenomena of coastal erosion, coastal flooding and shoreline retreat are expected to show a significant increase in frequency and intensity, in global level. The effects of coastal erosion are worsened by storms, and the reduction of sediment supply associated with global warming and anthropogenic modification of rivers and coastlines. As a countermeasure to coastal erosion, this work focuses on the development of coastal artificial in-situ rocks. We developed a new method that encompasses microbes and the related mechanism is called “Microbial Induced Carbonate Precipitation” (MICP). We successfully isolated three microorganisms, Micrococcus sp., Pseudoalteromonas sp., and Virgibacillus sp., from the selected area, and investigated their effectiveness in order to make a solidified sand sample. The precipitated bounding material has also been confirmed as calcite by XRD and XRF analysis. We successfully demonstrated that all of these bacterial species are very sensitive with certain environmental parameters, such as temperature, pH, culture type, culture duration, etc. In laboratory scale, we successfully obtained solidified sand by syringe (d = 2.3 cm, h = 7.1 cm) solidification method bearing UCS (Unconfined Compressive Strength) up to 1.8 MPa using 0.5 M CaCl2 and urea as cementation solution at 30°C. In addition, we propose a new sustainable approach for field implementation of this method through a combination of geotube and MICP mechanism, which will contribute to coastal erosion protection. The proposed approach is more economic, energy-saving, eco-friendly, and sustainable for bio-mediated soil improvement.

Mediterranean mid-altitude sites are critical for the survival of plant species allowing for elevational vegetation shifts in response to high-amplitude climate variability. Pollen records from the southern Balkans have underlined the importance of the region in preserving plant diversity over at least the last half a million years. So far, there are no records of vegetation and climate dynamics from Balkan refugia with an Early Pleistocene age. Here we present a unique palynological archive from such a refugium, the Lake Ohrid basin, recording continuously floristic diversity and vegetation succession under obliquity-paced climate oscillations. Palynological data are complemented by biomarker, diatom, carbonate isotope and sedimentological data to identify the mechanisms controlling shifts in the aquatic and terrestrial ecosystems within the lake and its catchment. The study interval encompasses four complete glacial-interglacial cycles (1365–1165 ka; MIS 43–35). Within the first 100 kyr of lake ontogeny, lake size and depth increase before the lake system enters a new equilibrium state as observed in a distinct shift in biotic communities and sediment composition. Several relict tree genera such as Cedrus, Tsuga, Carya, and Pterocarya played an important role in ecological succession cycles, while total relict abundance accounts for up to half of the total arboreal vegetation. The most prominent biome during interglacials is cool mixed evergreen needleleaf and deciduous broadleaf forests, while cool evergreen needleleaf forests dominate within glacials. A rather forested landscape with a remarkable plant diversity provide unique insights into Early Pleistocene ecosystem resilience and vegetation dynamics.

Geoscience courses, such as geology and geomorphology, require not only classroom lessons and laboratory exercises, but field trips as well. However, the COVID-19 restrictions did not allow the prosecution of most planned field trips, and an alternative needed to be developed. The use of virtual field trips is one such alternative. Through them, one can not only visit any area of interest, but prepare themselves for any actual educational or exploratory field trip as well. Even though they do not, and should not, substitute any physical visit of a site of interest, they have many advantages when combined with a "live" field work, in comparison to a field trip for which no preparation has been made.Through this research, we compare the advantages and disadvantages of both virtual and real educational field trips based on the opinions of our students. We thus performed a virtual navigation on the island of Naxos, Cyclades (Aegean Sea, Greece) for a series of virtual field trips, which took place during webinars in the framework of Erasmus+ CIVIS. The virtual fieldtrip was also presented to the third-year students of the Faculty of Geology & Geo-environment, National and Kapodistrian University of Athens, in the framework of the obligatory course of Geomorphology. Upon completion, all participating students were asked to fill in a questionnaire in order to evaluate the contribution of virtual field trips to their education regarding geomorphology and state their opinion as to whether they can supplement and/or substitute actual field trips. Most of them stated that virtual field trips can aid, but not substitute the actual field work. Most students mentioned that they would attend another virtual field trip in the future, both as an alternative to classroom lessons and as a means of preparation for an actual field trip, but not in order not to attend the actual one.

This study examines request perspective, the least researched form of mitigation in requesting, while focusing on a type of request characterised by a strong preference for the speaker perspective in English and the hearer perspective in most other languages researched to date. It examines requests produced by 900 speakers from 9 different (inter)language groups: five groups of native speakers (English, German, Greek, Polish and Russian) and four groups of advanced learners of English as a foreign language (German, Greek, Polish and Russian L1s). While the learners used more conventionally indirect forms than the native speakers of the respective L1s, thus showing awareness of this English pragmatic norm, they retained a preference for the hearer perspective. These results suggest a reliance on pragmatic universals as an alternative explanation to pragmatic transfer, also illustrating the need to address less salient pragmatic features in English language teaching.

Context. EE Cep is one of few eclipsing binary systems with a dark, dusty disc around an invisible object similar to ɛ Aur. The system is characterised by grey and asymmetric eclipses every 5.6 yr that have significant variations in their photometric depth, ranging from ∼0.m5 to ∼2.m0. Aims: The main aim of the observational campaign of the EE Cep eclipse in 2014 was to test the model of disc precession. We expected that this eclipse would be one of the deepest with a depth of ∼2.m0. Methods: We collected multicoloured observations from almost 30 instruments located in Europe and North America. These photometric data cover 243 nights during and around the eclipse. We also analyzed low- and high-resolution spectra from several instruments. Results: The eclipse was shallow with a depth of 0.m71 in the V band. The multicoloured photometry illustrates small colour changes during the eclipse with a total amplitude of order ∼+0.m15 in the B - I colour index. We updated the linear ephemeris for this system by including new times of minima, measured from the three most recent eclipses at epochs E = 9, 10, and 11. We acquired new spectroscopic observations, covering orbital phases around the eclipse, which were not observed in the past and increased the data sample, filling some gaps and giving better insight into the evolution of the Hα and Na I spectral line profiles during the primary eclipse. Conclusions: The eclipse of EE Cep in 2014 was shallower than expected, measuring 0.m71 instead of ∼2.m0. This means that our model of disc precession needs revision. Tables A1-A29 are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/cat/J/A+A/639/A23

Blazar emission models based on magnetic reconnection succeed in reproducing many observed spectral and temporal features, including the short-duration luminous flaring events. Plasmoids, a self-consistent by-product of the tearing instability in the reconnection layer, can be the main source of blazar emission. Kinetic simulations of relativistic reconnection have demonstrated that plasmoids are characterized by rough energy equipartition between their radiating particles and magnetic fields. This is the main reason behind the apparent shortcoming of plasmoid-dominated emission models to explain the observed Compton ratios of BL Lac objects. Here, we demonstrate that the radiative interactions among plasmoids, which have been neglected so far, can assist in alleviating this contradiction. We show that photons emitted by large, slow-moving plasmoids can be a potentially important source of soft photons to be then upscattered, via inverse Compton, by small fast-moving, neighbouring plasmoids. This interplasmoid Compton scattering process can naturally occur throughout the reconnection layer, imprinting itself as an increase in the observed Compton ratios from those short and luminous plasmoid-powered flares within BL Lac sources, while maintaining energy equipartition between radiating particles and magnetic fields.

The afterglow emission from gamma-ray bursts (GRBs) is believed to originate from a relativistic blast wave driven into the circumburst medium. Although the afterglow emission from radio up to X-ray frequencies is thought to originate from synchrotron radiation emitted by relativistic, non-thermal electrons accelerated by the blast wave, the origin of the emission at high energies (HE; ≳GeV) remains uncertain. The recent detection of sub-TeV emission from GRB 190114C by the Major Atmospheric Gamma Imaging Cherenkov Telescopes (MAGIC) raises further debate on what powers the very high energy (VHE; ≳300 GeV) emission. Here, we explore the inverse Compton scenario as a candidate for the HE and VHE emissions, considering two sources of seed photons for scattering: synchrotron photons from the blast wave (synchrotron self-Compton or SSC) and isotropic photon fields external to the blast wave (external Compton). For each case, we compute the multiwavelength afterglow spectra and light curves. We find that SSC will dominate particle cooling and the GeV emission, unless a dense ambient infrared photon field, typical of star-forming regions, is present. Additionally, considering the extragalactic background light attenuation, we discuss the detectability of VHE afterglows by existing and future gamma-ray instruments for a wide range of model parameters. Studying GRB 190114C, we find that its afterglow emission in the Fermi-Large Area Telescope (LAT) band is synchrotron dominated. The late-time Fermi-LAT measurement (I.e. t ∼ 104 s), and the MAGIC observation also set an upper limit on the energy density of a putative external infrared photon field (I.e. ${\lesssim} 3\times 10^{-9}\, {\rm erg\, cm^{-3}}$ ), making the inverse Compton dominant in the sub-TeV energies.

Understanding the governing mechanisms of atmosphere–wave–ocean​ interactions is critical for unravelling the formation and evolution mechanisms of severe weather phenomena. This study aims at investigating the effects of atmosphere–wave–ocean​ feedbacks on a Mediterranean tropical-like cyclone (medicane), occurred on 27–30 September 2018 at the central-eastern Mediterranean Sea and characterized by severe environmental and socioeconomic impact. To unveil the interactions across the air–sea interface, the medicane was simulated by an integrated modelling system consisting of the Chemical Hydrological Atmospheric Ocean wave System (CHAOS), upgraded by embedding to it the Nucleus for European Modelling of the Ocean (NEMO) as ocean circulation component. Coupled simulations revealed that air–seaheat transfer and Ekman pumping, bringing sub-surface cold waters in upper ocean layers (upwelling), caused SST cooling (∼2–3 °C). SST cooling triggered a negative feedback loop procedure tending to balance between atmospheric and ocean processes. It also attenuated the cyclone and, subsequently, reduced the atmospheric energy embedded in ocean through the upper ocean vertical stratification weakening, thus, upper ocean vertical mixing, upwelling and SST cooling. The waves adjusted this feedback loop making the system more resistant in air–sea flux variations. Waves additionally weakened the cyclone not only due to the kinetic energy loss in the lower-atmosphere but also due to the enhancement of SST cooling which is attributed to the strengthening of Ekman pumping and vertical mixing, forced by wind stress increase. Nevertheless, waves partially balanced the air–wave–sea exchanges through the slight enthalpy flux gain under high wind conditions which is explained by considering the increase of enthalpy transfer coefficient in rougher sea areas.

Reduction of the uranium(III) metallocene [(η 5 ‐C 5 i Pr 5 ) 2 UI] ( 1 ) with potassium graphite produces the “second‐generation” uranocene [(η 5 ‐C 5 i Pr 5 ) 2 U] ( 2 ), which contains uranium in the formal divalent oxidation state. The geometry of 2 is that of a perfectly linear bis(cyclopentadienyl) sandwich complex, with the ground‐state valence electron configuration of uranium(II) revealed by electronic spectroscopy and density functional theory to be 5f 3 6d 1 . Appreciable covalent contributions to the metal‐ligand bonds were determined from a computational study of 2 , including participation from the uranium 5f and 6d orbitals. Whereas three unpaired electrons in 2 occupy orbitals with essentially pure 5f character, the fourth electron resides in an orbital defined by strong 7s‐6d mixing.

Israeli deterrence strategy, as an integral part of its strategic behavior tout azimut,can briefly be outlined in terms of threats (including existential ones), challenges,operational initiatives, doctrine, and the regional balance of power. All of thesecan be examined in light of Turkey’s ongoing adventurism. Israel’s strategic behaviorwill be analyzed in comparison to Greece’s security challenges and policieswith regard to Turkey, which engages in aggressive tactics in the Eastern Mediterranean and the Middle East at the expense of Greek and Israeli vital interests.

BACKGROUND: Juvenile cystic adenomyomas (JCAs) are rare uterine lesions. Differential diagnosis might be difficult. We present the case of an adolescent who was diagnosed with JCA and was managed with laparoscopic excision. CASE: A 14-year-old patient with complaint of menarche with excruciating dysmenorrhea, was diagnosed using magnetic resonance imaging with a uterine anomaly consisting of a normal right hemiuterus, and a left cystic lesion with surrounding hypotense myometrium. She was managed with laparoscopic excision of the left side, and uterine reconstruction. Histology was suggestive of JCA, associated with diffuse adenomyosis. Dysmenorrhea improved considerably after surgery. SUMMARY AND CONCLUSION: Differential diagnosis between cystic uterine lesions relies on clinical, imaging, and perioperative clues that might assist in their formal classification. Doubt might still remain in some cases.

Three main aquifer systems developed on Kythira Island (Greece) include (Pagounis, 1981; Pagounis & Gertsos, 1984, Danamos, 1991; Koumantakis et al., 2006; Filis et al., 2019):

• The porous aquifer system in Neogene and Quaternary formations.
• The karst aquifer system in the carbonate formations of the Pindos and Tripolis Units.
• The aquifer system (both shallow and deep) in the fractured hard rocks mainly of the Phyllites – Quartzites Unit.

The main discharge of the aquifer systems takes place in coastal and submarine brackish springs around the island, except for its northern part where the Phyllites – Quartzites Unit outcrops and its central part where springs of small capacity discharge the carbonate formations of the Pindos Unit. Precipitation is the direct recharge of the three aforementioned aquifer systems while indirectly lateral discharge occurs in places between adjacent and tangential aquifer systems and from the streams runoff as well. In the area of Mylopotamos village four springs discharge the karst aquifer of the Pindos Unit within the channel of Kako Laghadi stream forming downstream the known “Neraida or Fonissa waterfall”. Moreover, along the dell of Kako Laghadi stream 22 watermills were built, among the plane trees and the ivy. The most significant of the aforementioned springs is the Kamari spring (+282.28 meters a.s.l.) which emerge at the thrust fault between the overlying permeable carbonates and the underlying impermeable flysch formation of the Pindos Unit. The discharge of the Kamari spring presents annual fluctuation which varies from app. 45-50 m3/h (during winter) to total recession (during summer), due to restriction of the precipitation and the prolonged drought and overpumping of its recharge area mainly with boreholes. The inactive municipal borehole of Mylopotamos village (+299.15 meters a.s.l.) is located app. 310 meters SSE of the Kamari spring within its recharge area (karst aquifer of the Pindos Unit). This borehole of a total depth of 40 meters penetrates carbonates of the Pindos Unit which thickness exceeds 100 meters in that area. Monthly measurements of the Kamari spring discharge and the water table head in the inactive borehole demonstrate clear and direct hydraulic correlation between them. The Kamari spring presents outflow only in the case when the water level head of the borehole exceeds +282.28 meters. This means that the water level head in the borehole should not exceed 16.87 meters from the earth surface. Taking into account all the aforementioned, the Kamari spring is designated as an overflow spring. Finally, microbiological analysis from the Kamari spring showed qualitative degradation, due to human activities in the wider area (Pagounis, 1981; Filis et al., 2019).

The state-of-the-art in surveying of open surface the last few decades is based on Point Cloud processing and interpretation. Lately, similar technology tends to be used for indoor surveying as well. One of the extreme applications is the use of the exact same technology in underground karstic cavities, evolving the methodology used in cave mapping. Geometric and morphometric analysis of the caves or any containing components (speleothems) include various techniques aiming at quantifying their dimensions in order to determine the characteristics and consequently the relationship between the cavity morphology and the surrounding structural, lithological and hydrogeological properties. The purpose of this research is to combine high resolution topographic data acquired with different instruments for both the underground morphology of a karstic cave (Koutouki, Peania, Greece) and the open-air surface above it. The described methodology is based on photogrammetric processing of Unmanned Aerial System image data and the extraction of a point cloud recorded with the use of a handheld laser scanning system. The latter resulted a 3D model of the cave and led to the production of a digital relief for the roof of the cave, which in turn was combined with the digital terrain model of the open-air surface above the cave. The final product is a high-resolution information layer with measurements of the rock thickness between the roof of the underground karstic structure and the open-surface topography with high accuracy.

© 2020 Informa UK Limited, trading as Taylor {&} Francis Group. Labial fusion in adolescence is uncommon and is usually secondary to other skin disorders or trauma of the vulvar area. In a five-year period, we treated five patients with labial fusion in our facility with a mean age of 16.4 years. Based on clinical presentation and biopsy of the vulvar skin, lichen sclerosus (LS) was the causative factor. Four out of five had urinary problems and one suffered from an inflamed inclusion cyst. All of them had a long history of pruritus. In all cases, blunt separation of the labia minora under general anaesthesia was performed, followed by local application of a potent glucocorticoid cream and an emollient agent. One patient received additionally oral and local antibiotics. One recurrence was noted, which resolved after re-separation and more meticulous treatment. Early identification and treatment of LS are crucial to prevent distortion of the vulvar anatomy.Impact StatementWhat is already known on this subject? Labial fusion is an uncommon problem in adolescence and an underlying cause should always be investigated. Lichen sclerosus typically affects the anogenital area and can lead to fusion of the labia minora. What do the results of this study add? Urinary symptoms may be the presenting feature of LS in adolescents. What are the implications of these findings for clinical practice and/or further research? Delay in diagnosis and appropriate treatment can result in irreversible changes to the vulva.

Greece and the Aegean area are among the first areas in Europe to have been occupied by humans. The record of human interventions in natural environments is thus particularly rich. Some of the interventions of the people inhabiting various localities of the country have been recorded in local mythology. Through the interdisciplinary field of geomythology it is possible to attempt to uncover the relationships between the geological history of early civilizations and ancient myths.In the present work, we focused on the history of Lake Lerni in the Eastern Peloponnese, an area that is better known through the myth of Hercules and the Lernaean Hydra. The area of the lake – now dried and cultivated – was part of a karstic system and constituted a marshland that was a source of diseases and needed to be dried.A new core is studied from the area of modern-day Lerni using palaeontological methods in order to reconstruct environmental changes that occurred during the last 6.000 years approximately. The area is known to have gone from marsh-lacustrine environments to dryer environments after human intervention or the intervention of Hercules according to mythology. Levels of peat considered to represent humid intervals were dated using the radiocarbon method so as to have an age model of the core. Samples of sediment were taken every 10 cm; the grain size was analysed for each sample as well as the fossil content for the environmental reconstruction.The presence of numerous freshwater gastropods reflects the intervals of lacustrine environment accompanied with extremely fine dark sediment. Sedimentology is stable throughout the core with few levels of coarse sand/fine gravel, only changes in colour hint to multiple levels richer in organic material.

In this article we use pollen data from six sites in southern Greece to study long-term vegetation change in this region from 1000 BCE to 600 CE. Based on insights from environmental history, we interpret our estimated trends in the regional presence of cereal, olive and vine pollen as proxies for structural changes in agricultural production. We present evidence that there was a market economy in ancient Greece and a major trade expansion several centuries before the Roman conquest. Our results are consistent with auxiliary data on settlement dynamics, shipwrecks and ancient oil and wine presses.

Geological failures from massive rockfall failures to small landslides of few cubic meters are a major geological hazard in many parts of the world. Based on the latest developments, close-range photogrammetry and individually UAV photogrammetry and Light Detection and Ranging systems have become indispensable tools for geo-experts in order to provide ultra high-resolution 3D models of the failure site. TLS suffers from the fact that is sometimes tricky to capture the holistic area of interest from the ground, while some areas may often be obscured by vegetation or negative inclinations. The science of photogrammetry has long been used to accurately detect and characterize landslide and rockfall failures. Due to the continuously increasing spatial resolution capability of new generation sensors, traditional pixel-based approaches are not capable to cope with the level of detail resulted from those sensors. Mostly, landslides present complex and dynamic geomorphological features with great heterogeneity in their spatial, spectral and contextual properties dependent on the specific failure mechanism. In the current study, an object-based 3D approach for the automated detection of landslide and rockfall hazard is presented based on detailed topographic photogrammetric point clouds and 3D analysis. Recent trends show that close photogrammetry will play a vital role on the geological and engineering geological assessments concerning geo-failures. The results show that object-based approach is closer to human interception due to integration of contextual and semantic, spectral and spatial information rather than translating pixel’s spectral information solely. The current procedure provides a detailed objective quantification of landslide characteristics and automated semantic landslide modelling of the case site.

Context. Deriving physical properties of trans-Neptunian objects is important for the understanding of our Solar System. This requires observational efforts and the development of techniques suitable for these studies. Aims: Our aim is to characterize the large trans-Neptunian object (TNO) 2002 TC302. Methods: Stellar occultations offer unique opportunities to determine key physical properties of TNOs. On 28 January 2018, 2002 TC302 occulted a mv ~ 15.3 star with designation 593-005847 in the UCAC4 stellar catalog, corresponding to Gaia source 130957813463146112. Twelve positive occultation chords were obtained from Italy, France, Slovenia, and Switzerland. Also, four negative detections were obtained near the north and south limbs. This represents the best observed stellar occultation by a TNO other than Pluto in terms of the number of chords published thus far. From the 12 chords, an accurate elliptical fit to the instantaneous projection of the body can be obtained that is compatible with the near misses. Results: The resulting ellipse has major and minor axes of 543 ± 18 km and 460 ± 11 km, respectively, with a position angle of 3 ± 1 degrees for the minor axis. This information, combined with rotational light curves obtained with the 1.5 m telescope at Sierra Nevada Observatory and the 1.23 m telescope at Calar Alto observatory, allows us to derive possible three-dimensional shapes and density estimations for the body based on hydrostatic equilibrium assumptions. The effective diameter in equivalent area is around 84 km smaller than the radiometrically derived diameter using thermal data from Herschel and Spitzer Space Telescopes. This might indicate the existence of an unresolved satellite of up to ~300 km in diameter, which is required to account for all the thermal flux, although the occultation and thermal diameters are compatible within their error bars given the considerable uncertainty of the thermal results. The existence of a potential satellite also appears to be consistent with other ground-based data presented here. From the effective occultation diameter combined with absolute magnitude measurements we derive a geometric albedo of 0.147 ± 0.005, which would be somewhat smaller if 2002 TC302 has a satellite. The best occultation light curves do not show any signs of ring features or any signatures of a global atmosphere. Tables A.1-A.3 are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/cat/J/A+A/639/A134

We develop ZnO/p-Si photodetectors by atomic layer deposition (ALD) of ZnO thin films on laser-microstructured silicon, and we investigate their electrical and optical behavior, demonstrating high sensitivity and broadband operation. Microstructured p-type silicon was obtained by nanosecond laser irradiation in SF6 gas, which results in the formation of quasi-ordered and uniform microspikes on the silicon surface. The irradiated silicon contains sulfur impurities, which extend its absorbance to the near-infrared. A thin film of ZnO was conformally deposited on the microstructured silicon substrates by ALD. Photoluminescence measurements indicate high crystalline quality of the ZnO film after annealing. Current-voltage (I-V) measurements of the ZnO/p-Si heterodiodes in the dark show a nonlinear behavior with unusual high current values in reverse bias. Under illumination photocurrent is observed for reverse bias, even for wavelengths below the silicon bandgap in the case of the laser-microstructured photodetectors. Higher current values are measured for the microstructured photodetectors compared to planar ones. Photoconductivity measurements show enhanced responsivity across the UV-vis-NIR spectral range for the laser-microstructured devices because of their increased surface area and light absorption. © 2020 American Chemical Society.

Sensory processing deficits and altered long-range connectivity putatively underlie Multisensory Integration (MSI) deficits in Autism Spectrum Disorder (ASD). The present study set out to investigate non-social MSI stimuli and their electrophysiological correlates in young neurotypical adolescents and adolescents with ASD. We report robust MSI effects at behavioural and electrophysiological levels. Both groups demonstrated normal behavioural MSI. However, at the neurophysiological level, the ASD group showed less MSI-related reduction of the visual P100 latency, greater MSI-related slowing of the auditory P200 and an overall temporally delayed and spatially constrained onset of MSI. Given the task design and patient sample, and the age of our participants, we argue that electro-cortical indices of MSI deficits in ASD: (a) can be detected in early-adolescent ASD, (b) occur at early stages of perceptual processing, (c) can possibly be compensated by later attentional processes, (d) thus leading to normal MSI at the behavioural level.

The present study focuses on the palynological investigation of a sediment core (S2P) recovered from Elefsis Bay, in the western part of Attica Peninsula (southern Greece). Until now, there is quite scarce knowledge about the vegetation history of southern Greece during Late Glacial and Holocene due to a deficiency of long high-resolution pollen records. The analyzed gravity core is a unique continuous and well-dated pollen archive, providing the opportunity for the reconstruction of the plant landscape succession in southern Greece since Late Glacial. In order evidence for the vegetation response to climate oscillations and human impact to be derived, detailed analyses were conducted throughout the sedimentary sequence, spanning the last 13,500 years. The pollen data suggest that temperate deciduous, open oak woodlands of Late Glacial were fully expanded during the onset of Holocene, without any pronounced setback due to climate oscillations as it has been previously indicated by pollen archives from northern Greece. Following this period, Middle Holocene is characterized by the establishment of complex vegetation patterns, partly as the result of human activities, which seem to be the dominant vegetation shaping factor during Late Holocene. Overall, our pollen record highlights the vegetation transition during Late Glacial and Holocene in southern Greece, while offering valuable insight into the plant landscape prior to the first signs of human impact on the environment.

The bedrock of Hymittos, Attic peninsula, Greece, exposes a pair of low-angle crustal-scale ductile-then-brittle detachment faults. The uppermost detachment fault separates sub-greenschist facies phyllite and marble of a Pelagonian Zone hanging wall, from greenschist facies metasedimentary schist, calc-schist, and marble correlated to the Cycladic Blueschist Unit. A second, structurally lower detachment fault subdivides the metamorphic rocks of the Cycladic blueschist unit footwall into middle and lower units. There is a marked step in metamorphic grade between the sub-greenschist facies uppermost package, and the middle-to-upper greenschist facies middle and lower packages. A suite of new white mica 40Ar/39Ar and zircon (U-Th)/He dates indicates accommodation of deformation along these faults occurred from the late Oligocene to the late Miocene with both faults active during the middle Miocene. The structures have clear top-S/SSW kinematics determined from flanking folds, sigmoids, shear bands, stair-stepping of strain shadows on porphyroclasts, and SCC' fabrics. The ductile-to-brittle deformation of the structures, morphology of the massif, and the increase in metamorphic grade suggest these low-angle structures are part of a major, crustal-scale extensional complex, located at the northwest end of the West Cycladic Detachment System, that accommodated Miocene bivergent exhumation of Attic-Cycladic metamorphic core complexes in the central Aegean. Taken together, the above data suggest that multiple coeval detachment branches may form in areas with high strain gradients to accommodate the mechanically necessary termination of Cycladic-style detachment systems.

En 1880 fut votée en France la loi relative à la création par l’État de l’enseignement secondaire de jeunes filles. Se posa dès lors la question du sexe du personnel qui allait se charger de l’enseignement dans les nouveaux établissements féminins. Dans son rapport de 1880 à la Chambre, Camille Sée, promoteur de l’œuvre, suggérait : « À mesure qu’il se présentera des femmes capables de donner l’enseignement, on devra les préférer et cela pour deux raisons : toutes les carrières sont fermées à la femme […] ; […] nous trouvons chez elle des qualités que nous chercherons en vain chez l’homme ». Par cette proposition le député républicain demandait, en substance, l’ouverture d’une nouvelle carrière intellectuelle pour les femmes. Son intervention impliquait, en même temps, néanmoins, la suppression d’un monopole masculin : le métier de professeur, étroitement associé au savoir et, subséquemment, à la raison et à l’abstraction, était, jusque-là, réservé « par nature » aux hommes. L’invention du « professeur femme » par la Troisième République se fit dans le cadre d’une entreprise de large envergure visant à la laïcisation de l’enseignement. Concrètement, ce nouveau corps féminin devait être investi de la mission d’arracher les jeunes bourgeoises, futures épouses et mères, à l’influence de l’Église. Sous ce rapport, des républicains, soucieux de ne point nuire au succès d’une œuvre si importante à leurs yeux pour la stabilité du régime même, s’employèrent, d’une part, à faire intégrer cette nouvelle figure de professionnelle à la norme féminine en la dotant des qualités de chasteté, de dévouement et d’abnégation caractérisant la religieuse qu’elle était appelée à remplacer dans le domaine de l’éducation des filles ; à lui procurer, d’autre part, une formation spécifique, adéquate à ses fonctions dans les nouveaux lycées féminins. Le but était, tout d’abord, de préparer les futures professeures à leurs responsabilités morales ; de leur donner, ensuite, accès à un savoir supérieur, certes, mais ayant tout de même un genre. Pour répondre à ces impératifs, les républicains fondèrent en 1881 à Sèvres une École normale supérieure, pendant féminin de celle qui fonctionnait pour les jeunes hommes, depuis le début du XIXe siècle, rue d’Ulm. Le présent traavail se propose de reconstituer – à travers l’étude de textes administratifs, de la presse spécialisée et associative de l’époque et de témoignages autobiographiques – la première grande étape de l’histoire fascinante de ce temple du savoir féminin sous la Troisième République.  L’accent est mis en particulier sur l’évolution des finalités d’une formation destinée à des femmes, sur les mutations du genre dans les programmes d’études et sur l’organisation des concours. Enfin, sont examinées les avancées vers l’assimilation avec la formation des professeurs hommes. The present work proposes to reconstruct the first major stage in the fascinating history of the École Normale Supérieure for young girls which took place in Sèvres itself. Particular emphasis is placed on the evolution of the aims of training for women, gender changes in curricula and in the organization of national competitions for professors. Finally, the progress towards assimilation with the training of male professors is examined.  

The article examines the critique of the French congregational schools of Smyrna in the late 19th century, carried out by Demetrius Georgiades, a Smyrniot trade manager and, at the same time, a French-speaking journalist and author. Through the study of his journals and books, published in Paris at the dawn of the new century, we have been able to trace the origins of the skepticism that preoccupies the public opinion inside and outside of France, in connection with the confessional character of schools. Under the pretext of defending the French interests in these remote regions, Georgiades examines the role of congregational schools in the penetration of French commerce and the expansion of French language and civilization in Asia Minor. The questions of functioning and financing of these schools do not escape Georgiadès’s caustic pen either. To strengthen his arguments, Georgiades compares the education provided by French schools to that of Smyrna’s other foreign communities.

Aspect-based sentiment prediction is a specific area of sentiment analysis that models the sentiment of a text excerpt as a multi-dimensional quantity pertaining to various interpretations, rather than a scalar one, that admits a single explanation. Extending earlier work, the said task is examined as a part of a unified architecture that collects, analyzes and stores documents from various online sources, including blogs & social network posts. The obtained data are processed at various levels; initially, a hybrid, attention-based bi-directional long short-term memory network, coupled with convolutional layers, is used to extract the textual features of the document. Following, an additional number of document metadata are also examined, such as the number of repetitions, the existence, type and frequency of emoji ideograms and, especially, the presence of keywords, assigned either manually (e.g. in the form of hashtags) or automatically. All of the aforementioned features are subsequently provided as input to a fully-connected, multi-layered, feed-forward artificial neural network that performs the final prediction task. The overall approach is tested on a large corpus of documents, with encouraging results.

AIMS: Levosimendan (LEVO) a clinically-used inodilator, exerts multifaceted cardioprotective effects. Case-studies indicate protection against doxorubicin (DXR)-induced cardiotoxicity, but this effect remains obscure. We investigated the effect and mechanism of different regimens of levosimendan on sub-chronic and chronic doxorubicin cardiotoxicity. METHODS AND RESULTS: Based on preliminary in vivo experiments, rats serving as a sub-chronic model of doxorubicin-cardiotoxicity and were divided into: Control (N/S-0.9%), DXR (18 mg/kg-cumulative), DXR+LEVO (LEVO, 24 mug/kg-cumulative), and DXR+LEVO (acute) (LEVO, 24 mug/kg-bolus) for 14 days. Protein kinase-B (Akt), endothelial nitric oxide synthase (eNOS), and protein kinase-A and G (PKA/PKG) pathways emerged as contributors to the cardioprotection, converging onto phospholamban (PLN). To verify the contribution of PLN, phospholamban knockout (PLN-/-) mice were assigned to PLN-/-/Control (N/S-0.9%), PLN-/-/DXR (18 mg/kg), and PLN-/-/DXR+LEVO (ac) for 14 days. Furthermore, female breast cancer-bearing (BC) mice were divided into: Control (normal saline 0.9%, N/S 0.9%), DXR (18 mg/kg), LEVO, and DXR+LEVO (LEVO, 24 mug/kg-bolus) for 28 days. Echocardiography was performed in all protocols. To elucidate levosimendan's cardioprotective mechanism, primary cardiomyocytes were treated with doxorubicin or/and levosimendan and with N omega-nitro-L-arginine methyl ester (L-NAME), DT-2, and H-89 (eNOS, PKG, and PKA inhibitors, respectively); cardiomyocyte-toxicity was assessed. Single bolus administration of levosimendan abrogated DXR-induced cardiotoxicity and activated Akt/eNOS and cAMP-PKA/cGMP-PKG/PLN pathways but failed to exert cardioprotection in PLN-/- mice. Levosimendan's cardioprotection was also evident in the BC model. Finally, in vitro PKA inhibition abrogated levosimendan-mediated cardioprotection, indicating that its cardioprotection is cAMP-PKA dependent, while levosimendan preponderated over milrinone and dobutamine, by ameliorating calcium overload. CONCLUSION: Single dose levosimendan prevented doxorubicin cardiotoxicity through a cAMP-PKA-PLN pathway, highlighting the role of inotropy in doxorubicin cardiotoxicity.

OBJECTIVE: The objective of this study was to translate the Menopause-specific Quality of Life (MENQOL) questionnaire in Greek and validate it for usage in the Greek population both in written and electronic form. METHODS: The original English questionnaire MENQOL with 1-month recall period was translated by our team. According to instructions by Mapi Research Trust, the questionnaire was forward and back-translated, followed by patient testing and proofreading. Then it was transcripted electronically. Validation was performed with the following tests: internal consistency (reliability), stability (test-retest reliability) with Cronbach's alpha correlations, independent and paired t tests, and Pearson's correlation coefficients. RESULTS: A total of 105 women, the majority recently menopausal, participated in the study. Internal consistency using the Cronbach's alpha showed high reliability ranging between 0.833 (physical domain) and 0.896 (vasomotor domain) for the written, and 0.720 (physical domain) and 0.868 (vasomotor domain) for the online form. Test-retest reliability was also high for both forms. The sexual domain of MENQOL had the higher mean, indicating the highest impact on quality of life (3.80 ± 2.35). CONCLUSIONS: The Greek version of MENQOL is a reliable instrument for evaluating menopausal women. Availability of an online form will allow wider dissemination of the questionnaire. Further use of the questionnaire in Greece may lead to better understanding of the bothersome symptoms of menopause; a prerequisite to develop intervention studies for amelioration of quality of life.

This article presents results from a needs analysis survey conducted in the first year of a European-funded project entitled ‘Teachers’ Assessment Literacy Enhancement (TALE)’. The survey questionnaire used asked 1788 learners of English in Cyprus, Germany, Greece and Hungary about their experiences of assessment; which of these they considered conducive to learning and the role feedback played as an instrument of formative assessment. Further questionnaire data from their 658 teachers were included in the data analysis. The results showed that practices differed across contexts. Overall, both learners and teachers reported a wide range of skills and areas to be assessed in the EFL classroom with writing, followed by speaking, being assessed the most. Based on the perceptions reported by the learners, the assessment types used revealed rather traditional approaches with frequent use of e.g. discrete-point tests with closed answers, extended writing and translation. The learners appeared to regard these types of assessment to be supportive of their learning. Feedback given was mostly restricted to marks and brief comments. The perceptions on feedback practices varied among teachers and their learners. Results of the needs analysis were taken as the basis of the online course design for enhancing teachers’ language assessment literacy.

El presente trabajo pretende investigar el uso de los extranjerismos como estrategia de comunicación en la producción escrita de aprendices griegos de español. Según la teorías, el uso de las estrategias de comunicación basadas en la lengua materna y en los conocimientos de otras LE tienden a disminuir a medida que avanza el nivel lingüístico de los aprendices de LE. Además, se ha demostrado que uno de los factores que regula dicho proceso es la distancia lingüística entre la LM, la lengua que está aprendiendo el alumno y las otras LE que conoce. En este estudio en concreto, utilizando la metodología del Análisis de Errores analizamos los extranjerismos de la producción escrita de 3 grupos de aprendices griegos de español de diferente nivel lingüístico en español (B1, B2, C1), que conocen diferentes LE. Los resultados del análisis cuantitativo muestran que el uso de los extranjerismos tiende a disminuir a medida que avanza el nivel lingüístico en español. Mientras que los resultados del análisis cualitativo indican que los aprendices griegos a la hora de emplear la estrategia de los extranjerismos no se basan en su lengua materna sino más bien en las otras LE que conocen.

Liver fibrosis is characterized by the excessive accumulation of extracellular matrix (ECM) proteins and enzymes, especially fibrillary collagens, and represents a major cause of morbidity and mortality worldwide. Lysyl oxidases (LOXs) drive covalent crosslinking of collagen fibers, thereby promoting stabilization and accumulation of liver fibrosis while limiting its resolution. Here we show in a carbon tetrachloride (CCl4)-induced liver fibrosis murine model that treatment with a novel anti-lysyl oxidase like 2 (LOXL2) neutralizing antibody, which targets extracellular LOXL2, significantly improves fibrosis resolution. LOXL2 inhibition following the onset of fibrosis accelerated and augmented collagen degradation. This was accompanied by increased localization of reparative monocyte-derived macrophages (MoMFs) in the proximity of fibrotic fibers and their representation in the liver. These cells secreted collagenolytic matrix metalloproteinases (MMPs) and, in particular, the membrane-bound MT1-MMP (MMP-14) collagenase. Inducible and selective ablation of infiltrating MoMFs negated the increased "on-fiber" accumulation of MMP-14-expressing MoMFs and the accelerated collagenolytic activity observed in the anti-LOXL2-treated mice. Many studies of liver fibrosis focus on preventing the progression of the fibrotic process. In contrast, the therapeutic mechanism of LOXL2 inhibition presented herein aims at reversing existing fibrosis and facilitating endogenous liver regeneration by paving the way for collagenolytic macrophages.

In this work, we explore the applicability of standard theoretical models of accretion to the observed properties of M51 ULX-7. The spin-up rate and observed X-ray luminosity are evidence of a neutron star with a surface magnetic field of 2-7 × 1013 G, rotating near equilibrium. Analysis of the X-ray light curve of the system (Swift/XRT data) reveals the presence of a ∼39 d superorbital period. We argue that the superorbital periodicity is due to disc precession, and that material is accreted on to the neutron star at a constant rate throughout it. Moreover, by attributing this modulation to the free precession of the neutron star we estimate a surface magnetic field strength of 3-4 × 1013 G. The agreement of these two independent estimates provide strong constraints on the surface polar magnetic field strength of the NS.

This paper studies on “Early Warning Systems” (EWS) by investigating possible contagion risks, based on structured financial networks. Early warning indicators improve standard crisis prediction models performance. Using network analysis and machine learning algorithms we find evidence of contagion risk on the dates where we observe significant increase in correlations and centralities. The effectiveness of machine learning reached 98.8%, making the predictions extremely accurate. The model provides significant information to policymakers and investors about employing the financial network as a useful tool to improve portfolio selection by targeting assets based on centrality.

Magneto-optical materials have become a key tool in functional nanophotonics, mainly due to their ability to offer active tuning between two different operational states in subwavelength structures. In the long-wavelength limit, such states may be considered as the directional forward- and back-scattering operations, due to the interplay between magnetic and electric dipolar modes, which act as equivalent Huygens sources. In this work, on the basis of full-wave electrodynamic calculations based on a rigorous volume integral equation (VIE) method, we demonstrate the feasibility of obtaining magnetically-tunable directionality inversion in spherical microresonators (THz antennas) coated by magnetooptical materials. In particular, our analysis reveals that when a high-index dielectric is coated with a magnetooptical material, we can switch the back-scattering of the whole particle to forward-scattering simply by turning off/ on an external magnetic field bias. The validity of our calculations is confirmed by reproducing the above two-state operation, predicted by the VIE, with full-wave finite-element commercial software. Our results are of interest for the design of state-of-the-art active metasurfaces and metalenses, as well as for functional nanophotonic structures, and scattering and nanoantennas engineering. © 2020 Grigorios P. Zouros et al., published by De Gruyter. This work is licensed under the Creative Commons Attribution 4.0 International License.

 

The sarcomere is the basic unit of the myofibrils, which mediate skeletal and cardiac Muscle contraction. Two transverse structures, the Z-disc and the M-band, anchor the thin (actin and associated proteins) and thick (myosin and associated proteins) filaments to the elastic filament system composed of titin. A plethora of proteins are known to be integral or associated proteins of the Z-disc and its structural and signalling role in muscle is better understood, while the molecular constituents of the M-band and its function are less well defined. Evidence discussed here suggests that the M-band is important for managing force imbalances during active muscle contraction. Its molecular composition is fine-tuned, especially as far as the structural linkers encoded by members of the myomesin family are concerned and depends on the specific mechanical characteristics of each particular muscle fibre type. Muscle activity signals from the M-band to the nucleus and affects transcription of sarcomeric genes, especially via serum response factor (SRF). Due to its important role as shock absorber in contracting muscle, the M-band is also more and more recognised as a contributor to muscle disease.

Chronic pain manifests in multiple disorders and is highly debilitating. While its pathophysiology is not fully understood, the involvement of the mesocorticolimbic monoaminergic systems have been shown to play a critical role in chronic pain emergence and/or maintenance. In this study, we analyzed the levels of monoamines dopamine (DA), noradrenaline (NA) and serotonin (5-HT) in mesocorticolimbic areas - medial prefrontal cortex, orbitofrontal cortex, striatum, nucleus accumbens and amygdala - 1 month after a neuropathic lesion, Spared Nerve Injury (SNI). In SNI animals, were observed a marginal decrease of DA and 5-HT in the striatum and a rightward shift in the levels of NA in the nucleus accumbens. While mesocorticolimbic monoamines might be relevant for chronic pain pathophysiology its content appears to be relatively unaffected in our experimental conditions.

Mezirow was introduced to Gould’s ideas in the mid-1970s, when the latter was practicing psychiatry at UCLA Outpatient and Community Psychiatry Center. At that time, Mezirow was in the early stages developing his theory of transformation and became particularly interested in the work that Gould was carrying out with psychodynamic groups in psychiatric settings. In 1980, Mezirow was granted a Teacher’s College sabbatical and was invited by Gould to spend some months as a counsellor in his laboratory. Gould and Mezirow had distinct routes and professional origins that are important to bear in mind in any type of comparison or analogue that one would like to draw. Gould was a psychiatrist and an expert in adult developmental psychology. He was not involved in educational theory. At the time he met Mezirow, Gould was focusing his research interests on the developmental stages of adult life through group observation methods and analyses that included life narratives of psychiatrists, treatment staff, and patients with mental health problems. These studies formed the basis of Gould’s theory of individual change and perhaps his most significant theoretical contribution on developmental psychology and adult theory of change. Later, Gould (1990, 1995, 1996) developed a computer-assisted self-help Therapeutic Learning Program (TLP) focused on the treatment of eating disorders and the anxiety that is associated with them. The program was accompanied in 2008 by the publication of the self-help manual Shrink Yourself (Gould, 2008), that was widely accepted in the United States, where eating disorders seem to be a major concern. Gould’s theory on adult developmental stages and subsequent transformations exerted an important influence on Mezirow’s concept of perspective transformation. Therefore, the relationship between Gould and Mezirow deserves attention in a volume dedicated to Transformation Theory.

Aging research aims at developing interventions that delay normal aging processes and some related pathologies. Recently, many compounds and extracts from natural products have been shown to delay aging and/or extend lifespan. Marine sponges and their associated microorganisms have been found to produce a wide variety of bioactive secondary metabolites; however, those from the Southwest of the Indian Ocean are much less studied, especially regarding anti-aging activities. In this study, the microbial diversity of the marine sponge Scopalina hapalia was investigated by metagenomic analysis. Twenty-six bacterial and two archaeal phyla were recovered from the sponge, of which the Proteobacteria phylum was the most abundant. In addition, thirty isolates from S. hapalia were selected and cultivated for identification and secondary metabolites production. The selected isolates were affiliated to the genera Bacillus, Micromonospora, Rhodoccocus, Salinispora, Aspergillus, Chaetomium, Nigrospora and unidentified genera related to the family Thermoactinomycetaceae. Crude extracts from selected microbial cultures were found to be active against seven targets i.e., elastase, tyrosinase, catalase, sirtuin 1, Cyclin-dependent kinase 7 (CDK7), Fyn kinase and proteasome. These results highlight the potential of microorganisms associated with a marine sponge from Mayotte to produce anti-aging compounds. Future work will focus on the isolation and the characterization of bioactive molecules.

Ovarian cancer (OC) remains a leading cause of gynecological cancer-related death worldwide, characterized by poor 5-year survival. Molecular markers could serve as crucial tools of personalized prognosis and therapy. Herein, we present miR-181a as novel predictor of OC prognosis, using five independent OC cohorts. In particular, a screening (n = 81) and an institutionally independent validation (n = 100, OVCAD multicenter study) serous OC (SOC) cohorts were analyzed. Bagnoli et al (2016) OC179 (n = 124) to OC133 (n = 100) and TCGA (n = 489) served as external validation cohorts. Patients' survival and disease progression were assessed as clinical endpoint events. Bootstrap analysis was performed for internal validation and decision curve analysis was utilized to evaluate clinical benefit. miR-181a overexpression was unveiled as powerful and independent molecular predictor of patients' poor survival and higher risk for disease progression after debulking surgery and platinum-based chemotherapy. Analysis of the OVCAD institutionally independent cohort, as well as of Bagnoli et al. and TCGA external cohorts further confirmed the unfavorable prognostic nature of miR-181a overexpression in SOC. Strikingly, multivariate prognostic models incorporating miR-181a with established disease markers clearly improved patients' risk-stratification and offered superior clinical benefit in OC prognostication. Conclusively, miR-181a evaluation could augment prognostic accuracy and support precision medicine decisions in OC.

Ovarian cancer (OC) accounts for the most gynecological cancer-related deaths in developed countries. Unfortunately, the lack of both evident early symptoms and effective asymptomatic population screening results in late diagnosis and inevitably poor prognosis. Hence, it is urgent to identify novel molecular markers to support personalized prognosis. In the present study, we have analyzed the clinical significance of miR-203 in OC using two institutionally independent cohorts. miR-203 levels were quantified in a screening (n = 125) and a validation cohort (n = 100, OVCAD multicenter study). Survival analysis was performed using progression and death as clinical endpoint events. Internal validation was conducted by bootstrap analysis, and decision curve analysis was used to evaluate the clinical benefit. Increased miR-203 levels in OC patients were correlated with unfavorable prognosis and higher risk for disease progression, independently of FIGO stage, tumor grade, residual tumor after surgery, chemotherapy response and age. The analysis of the institutionally independent validation cohort (OVCAD study) clearly confirmed the shorter survival outcome of the patients overexpressing miR-203. Additionally, integration of miR-203 levels with the established disease prognostic markers led to a superior stratification of OC patients that can ameliorate prognosis and benefit patient clinical management. In this regard, miR-203 expression constitutes a novel independent molecular marker to improve patients' prognosis in OC.

Neurodegenerative diseases are strongly age-related and currently cannot be cured, with a surge of patient numbers in the coming decades in view of the emerging worldwide ageing population, bringing healthcare and socioeconomic challenges. Effective therapies are urgently needed, and are dependent on new aetiological mechanisms. In neurons, efficient clearance of damaged mitochondria, through the highly evolutionary conserved cellular process termed mitophagy, plays a fundamental role in mitochondrial and metabolic homeostasis, energy supply, neuronal survival, and health. Conversely, defective mitophagy leads to accumulation of damaged mitochondria and cellular dysfunction, contributing to ageing and age-predisposed neurodegeneration. Here, we discuss the contribution of defective mitophagy in these diseases, and underlying molecular mechanisms, and highlight novel therapeutics based on new discovered mitophagy-inducing strategies.

Battling human neurodegenerative pathologies and managing their pervasive socioeconomic impact is becoming a global priority. Notwithstanding their detrimental effects on the human life quality and the healthcare system, the majority of human neurodegenerative disorders still remain incurable and non-preventable. Therefore, the development of novel therapeutic interventions against such maladies is becoming a pressing urgency. Age-associated deterioration of neuronal circuits and function is evolutionarily conserved in organisms as diverse as the lowly worm Caenorhabditis elegans and humans, signifying similarities in the underlying cellular and molecular mechanisms. C. elegans is a highly malleable genetic model, which offers a well-characterized nervous system, body transparency and a diverse repertoire of genetic and imaging techniques to assess neuronal activity and quality control during ageing. Here, we introduce and describe methodologies utilizing some versatile nematode models, including hyperactivated ion channel-induced necrosis (e.g., deg-3(d) and mec-4(d)) and protein aggregate (e.g., alpha-syunclein and poly-glutamate)-induced neurotoxicity, to monitor and dissect the cellular and molecular underpinnings of age-related neuronal breakdown. A combination of these animal neurodegeneration models, together with genetic and pharmacological screens for cell death modulators will lead to an unprecedented understanding of age-related breakdown of neuronal function and will provide critical insights with broad relevance to human health and quality of life.

BACKGROUND.: The aim of the current study was to explore the changing interrelationships among clinical variables through the stages of schizophrenia in order to assemble a comprehensive and meaningful disease model. METHODS.: Twenty-nine centers from 25 countries participated and included 2358 patients aged 37.21 ± 11.87 years with schizophrenia. Multiple linear regression analysis and visual inspection of plots were performed. RESULTS.: The results suggest that with progression stages, there are changing correlations among Positive and Negative Syndrome Scale factors at each stage and each factor correlates with all the others in that particular stage, in which this factor is dominant. This internal structure further supports the validity of an already proposed four stages model, with positive symptoms dominating the first stage, excitement/hostility the second, depression the third, and neurocognitive decline the last stage. CONCLUSIONS.: The current study investigated the mental organization and functioning in patients with schizophrenia in relation to different stages of illness progression. It revealed two distinct "cores" of schizophrenia, the "Positive" and the "Negative," while neurocognitive decline escalates during the later stages. Future research should focus on the therapeutic implications of such a model. Stopping the progress of the illness could demand to stop the succession of stages. This could be achieved not only by both halting the triggering effect of positive and negative symptoms, but also by stopping the sensitization effect on the neural pathways responsible for the development of hostility, excitement, anxiety, and depression as well as the deleterious effect on neural networks responsible for neurocognition.

This study quantifies the effects of the Fed’s quantitative easing (QE) and tapering programs’ announcements on professionals’ consensus forecasts of U.S. macroeconomic and financial variables at different forecast horizons. The results of a vector autoregression (VAR) analysis show that the first QE (QE1) program is more effective in terms of significantly affecting the variability of near and medium term forecasts on GDP, inflation and short-term interest rates. This is not the case for these variables of long forecast horizons across all QE/tapering announcements, the forecasts of U.S. currency and long-term rates present significant short-lived responses, while the tapering displays a dominant effect on the volatility of long-term rates across long-term forecast horizons. A dynamic correlation analysis among different horizon forecasts also reveals that the Fed successfully anchor inflation and real economic growth expectations during the expansionary policy (QE) periods. Additional findings show the anchoring of the expectations across different horizons on short-term rates, as opposed to long-term rates, during the QE1 program. During the contractionary (tapering) period, the decrease in the correlations among different horizons for the short-term rates’ forecasts is a sign that the Fed increases the range of possible outcomes and highlights a signal of a monetary policy change.

BACKGROUND: The spread of SARS-CoV-2 generated an unprecedented global public health crisis. Soon after Asia, Europe was seriously affected. Many countries, including Romania, adopted lockdown measures to limit the outbreak. AIM: We performed a molecular epidemiology analysis of SARS-CoV-2 viral strains circulating in Romania during the first two months of the epidemic in order to detect mutation profiles and phylogenetic relatedness. METHODS: Respiratory samples were directly used for shotgun sequencing. RESULTS: All Romanian sequences belonged to lineage B, with a different subtype distribution between northern and southern regions (subtype B.1.5 and B.1.1). Phylogenetic analysis suggested that the Romanian epidemic started with multiple introduction events from other European countries followed by local transmission. Phylogenetic links between northern Romania and Spain, Austria, Scotland and Russia were observed, as well as between southern Romania and Switzerland, Italy, France and Turkey. One viral strain presented a previously unreported mutation in the Nsp2 gene, namely K489E. Epidemiologically-defined clusters displayed specific mutations, suggesting molecular signatures for strains coming from areas that were isolated during the lockdown. CONCLUSIONS: Romanian epidemic was initiated by multiple introductions from European countries followed by local transmissions. Different subtype distribution between northern and southern Romania was observed after two months of the pandemic.

Asynchronous movement of the carotid atheromatous plaque from B-mode ultrasound has been previously reported, and associated with higher risk of stroke, but not quantitatively estimated. Based on the hypothesis that asynchronous plaque motion is associated with vulnerable plaque, in this study, synchronisation patterns of different tissue areas were estimated using cross-correlations of displacement waveforms. In 135 plaques (77 subjects), plaque radial deformation was synchronised by approximately 50% with the arterial diameter, and the mean phase shift was 0.4 s. Within the plaque, the mean phase shifts between the displacements of the top and bottom surfaces were 0.2 s and 0.3 s, in the radial and longitudinal directions, respectively, and the synchronisation about 80% in both directions. Classification of phase-shift-based features using Random Forests yielded Area-Under-the-Curve scores of 0.81, 0.79, 0.89 and 0.90 for echogenicity, symptomaticity, stenosis degree and plaque risk, respectively. Statistical analysis showed that echolucent, high-stenosis and high-risk plaques exhibited higher phase shifts between the radial displacements of their top and bottom surfaces. These findings are useful in the study of plaque kinematics.

The IceCube report of a ∼ 3.5σ excess of 13 ± 5 neutrino events in the direction of the blazar TXS 0506+056 in 2014-2015 and the 2017 detection of a high-energy neutrino event, IceCube-170922A, during a gamma-ray flare from the same blazar, have revived the interest in scenarios for neutrino production in blazars. We perform comprehensive analyses on the long-term electromagnetic emission of TXS 0506+056 using optical, X-ray, and gamma-ray data from the All-Sky Automated Survey for Supernovae, the Neil Gehrels Swift Observatory, Monitor of All-sky X-ray Image, and the Fermi Large Area Telescope. We also perform numerical modeling of the spectral energy distributions (SEDs) in four epochs prior to 2017 with contemporaneous gamma-ray and lower-energy (optical and/or X-ray) data. We find that the multi-epoch SEDs are consistent with a hybrid leptonic scenario, where the gamma-rays are produced in the blazar zone via external inverse Compton scattering of accelerated electrons, and high-energy neutrinos are produced via the photomeson production process of co-accelerated protons. The multi-epoch SEDs can be satisfactorily explained with the same jet parameters and variable external photon density and electron luminosity. Using the maximal neutrino flux derived for each epoch, we put an upper limit of ∼0.4-2 on the muon neutrino number in 10 years of IceCube observations. Our results are consistent with the IceCube-170922A detection, which can be explained as an upper fluctuation from the average neutrino rate expected from the source, but in strong tension with the 2014-2015 neutrino flare.

The IceCube report of a ∼ 3.5σ excess of 13 ± 5 neutrino events in the direction of the blazar TXS 0506+056 in 2014-2015 and the 2017 detection of a high-energy neutrino event, IceCube-170922A, during a gamma-ray flare from the same blazar, have revived the interest in scenarios for neutrino production in blazars. We perform comprehensive analyses on the long-term electromagnetic emission of TXS 0506+056 using optical, X-ray, and gamma-ray data from the All-Sky Automated Survey for Supernovae, the Neil Gehrels Swift Observatory, Monitor of All-sky X-ray Image, and the Fermi Large Area Telescope. We also perform numerical modeling of the spectral energy distributions (SEDs) in four epochs prior to 2017 with contemporaneous gamma-ray and lower-energy (optical and/or X-ray) data. We find that the multi-epoch SEDs are consistent with a hybrid leptonic scenario, where the gamma-rays are produced in the blazar zone via external inverse Compton scattering of accelerated electrons, and high-energy neutrinos are produced via the photomeson production process of co-accelerated protons. The multi-epoch SEDs can be satisfactorily explained with the same jet parameters and variable external photon density and electron luminosity. Using the maximal neutrino flux derived for each epoch, we put an upper limit of ∼0.4-2 on the muon neutrino number in 10 years of IceCube observations. Our results are consistent with the IceCube-170922A detection, which can be explained as an upper fluctuation from the average neutrino rate expected from the source, but in strong tension with the 2014-2015 neutrino flare.

A thorough theoretical study of the optical properties of periodic Si nanosphere arrays is undertaken, placing a particular emphasis on the synergy between multipolar, electric and magnetic, Mie resonances, which occur in high-refractive-index nanoparticles and can lead to a rich variety of phenomena ranging from perfect reflection to controlled diffraction. Systematic calculations using the layer-multiple-scattering method, which we properly extended to describe periodic arrays with many different scatterers per unit cell, in conjunction with finite-element simulations are presented. It is shown that rectangular arrays of pairs of Si nanospheres can efficiently diffract light in reflection or transmission mode at large angles as well as split light with minimum backreflection by properly adjusting the geometry of the structure. Our rigorous full-electrodynamic calculations highlight the importance of higher-order multipoles, which are not taken into account in the commonly employed dipole approximation, in the description of these effects.

The paleoenvironmental evolution of Lake Ismarida in Thrace (Northern Greece) is revealed by the combined lithological, micropaleontological (benthic foraminifera, pollen and NPPS), molluscan analyses, magnetic susceptibility measurement and radiocarbon dating of a 5.8-m long sediment core. The mid Holocene evolution of the lake area is evidenced by the documentation of four sedimentary Units in the core ISMR-2, corresponding to four distinct evolutionary stages: (1) during ∼5500-3500 cal yr BP the lake area was a shallow marine environment characterized by an Ammonia beccarii, small rotaliids, miliolids, Bittium reticulatum and Veneridae spp. assemblage, marine dinoflagellate cysts, and low magnetic susceptibility values; (2) during ∼3500-3000 cal BP the environment is gradually tending to more isolated conditions forming an open lagoon, characterized by marine and euryhaline fauna and low magnetic susceptibility values; (3) during 3000 cal yr BP, the open lagoon presented a transition to an oligohaline inner lagoon, characterized by an Ammonia tepida, Haynesina germanica, Aubignyna perlucida, Pirenella conica, Cerastoderma glaucum and Abra spp. assemblage, sedges and aquatic vegetation. This restricted, entirely isolated from the sea inner lagoon could be definitely used as the landmark of the Lake Ismaris from Heorodotus, while describing the march of Xerxes through Thrace in 480 B.C.; (4) since ∼2000 cal yr BP to the present, the Lake Ismarida is formed, characterized by fresh-water indicators and aquatic pollen, Pseudoschizaea and high magnetic susceptibility values. Finally, the progradation of the Filiouris River deltaic deposits resulted to a 4 km wide deltaic plain between Lake Ismarida and the nowadays coastline. Pollen assemblages record the dominance of a rather rich deciduous forest in the area with traces of human presence in the lower part of the sequence, whereas the opening of the plant landscape under the increasing human pressure is evidenced after ∼ 3000 cal yr BP. Finally, an open vegetation pattern, contemporaneous with the retreat of forest vegetation, is evidenced in the area already before 2000 cal yr BP.

Our aim was to investigate the dispersal patterns and parameters associated with local molecular transmission clusters (MTCs) of subtypes A1 and B in Greece (predominant HIV-1 subtypes). The analysis focused on 1751 (28.4%) and 2575 (41.8%) sequences of subtype A1 and B, respectively. Identification of MTCs was based on phylogenetic analysis. The analyses identified 38 MTCs including 2-1518 subtype A1 sequences and 168 MTCs in the range of 2-218 subtype B sequences. The proportion of sequences within MTCs was 93.8% (1642/1751) and 77.0% (1982/2575) for subtype A1 and B, respectively. Transmissions within MTCs for subtype A1 were associated with risk group (Men having Sex with Men vs. heterosexuals, OR = 5.34, p < 0.001) and Greek origin (Greek vs. non-Greek origin, OR = 6.05, p < 0.001) and for subtype B, they were associated with Greek origin (Greek vs. non-Greek origin, OR = 1.57, p = 0.019), younger age (OR = 0.96, p < 0.001), and more recent sampling (time period: 2011-2015 vs. 1999-2005, OR = 3.83, p < 0.001). Our findings about the patterns of across and within country dispersal as well as the parameters associated with transmission within MTCs provide a framework for the application of the study of molecular clusters for HIV prevention.

Guided by the self-determination theory, this weekly diary study tested a process model in which week-to-week mother-reported interparental conflict and perceived partner responsiveness were associated with maternal autonomy support by means of maternal psychological need satisfaction. During six consecutive weeks, 258 mothers (Mage = 41.71 years) and their 157 adolescents (51.4% females, Mage = 14.92 years) from Turkey provided weekly reports of the study variables via an online survey. Multilevel analyses showed that maternal need satisfaction was predicted by lower levels of interparental conflict and greater levels of perceived partner responsiveness. Maternal need satisfaction, in turn, was positively associated with maternal and adolescent reports of maternal autonomy support. Further, these week-to-week associations were partly moderated by maternal perfectionism. The results underscore the dynamic nature of the intra-family relationships, the important role of particular conditions in which mothers may become more autonomy supportive, and the necessity to consider mother’s personal characteristics while examining these dynamics.

Maintenance of neuronal homeostasis is a challenging task, due to unique cellular organization and bioenergetic demands of post-mitotic neurons. It is increasingly appreciated that impairment of mitochondrial homeostasis represents an early sign of neuronal dysfunction that is common in both age-related neurodegenerative as well as in neurodevelopmental disorders. Mitochondrial selective autophagy, known as mitophagy, regulates mitochondrial number ensuring cellular adaptation in response to several intracellular and environmental stimuli. Mounting evidence underlines that deregulation of mitophagy levels has an instructive role in the process of neurodegeneration. Although mitophagy induction mediates the elimination of damaged mitochondria and confers neuroprotection, uncontrolled runaway mitophagy could reduce mitochondrial content overstressing the remaining organelles and eventually triggering neuronal cell death. Unveiling the molecular mechanisms of neuronal mitophagy and its intricate role in neuronal survival and cell death, will assist in the development of novel mitophagy modulators to promote cellular and organismal homeostasis in health and disease.

The IceCube collaboration reported an ∼3.5σ excess of 13 ± 5 neutrino events in the direction of the blazar TXS 0506+056 during an ∼6 month period in 2014-2015, as well as the (∼3σ) detection of a high-energy muon neutrino during an electromagnetic flare in 2017. We explore the possibility that the 2014-2015 neutrino excess and the 2017 multimessenger flare are both explained in a common physical framework that relies on the emergence of a relativistic neutral beam in the blazar jet due to interactions of accelerated cosmic rays (CRs) with photons. We demonstrate that the neutral beam model provides an explanation for the 2014-2015 neutrino excess without violating X-ray and γ-ray constraints and yields results consistent with the detection of one high-energy neutrino during the 2017 flare. If both neutrino associations with TXS 05065+056 are real, our model requires that (I) the composition of accelerated CRs is light, with a ratio of helium nuclei to protons ≳5; (II) a luminous external photon field (∼1046 erg s-1) variable (on yearlong timescales) is present; and (III) the CR injection luminosity, as well as the properties of the dissipation region (I.e., Lorentz factor, magnetic field, and size), vary on yearlong timescales.

Knowledge and visualization of the present-day relationship between earthquakes, active tectonics and crustal deformation is a key to understanding geodynamic processes, and is also essential for risk mitigation and the management of geo-reservoirs for energy and waste. The study of the complexity of the Greek tectonics has been the subject of intense efforts of our working group, employing multidisciplinary methodologies that include detailed geological mapping, geophysical and seismological data processing using innovative methods and geodetic data processing, involved in surveying at various scales. The data and results from these studies are merged with existing or updated datasets to compose the new Seismotectonic Atlas of Greece. The main objective of the Atlas is to harmonize and integrate the most recent seismological, geological, tectonic, geophysical and geodetic data in an interactive, online GIS environment. To demonstrate the wealth of information available in the end product, herein, we present thematic layers of important seismotectonic and geophysical content, which facilitates the comprehensive visualization and first order insight into seismic and other risks of the Greek territories. The future prospect of the Atlas is the incorporation of tools and algorithms for joint analysis and appraisal of these datasets, so as to enable rapid seismotectonic analysis and scenario-based seismic risk assessment.

A novel finite-time convergent zeroing neural network (ZNN) based on varying gain parameter for solving time-varying (TV) problems is presented. The model is based on the improvement and generalization of the finite-time ZNN (FTZNN) dynamics by means of the varying-parameter ZNN (VPZNN) dynamics, and termed as VPFTZNN. More precisely, the proposed model replaces fixed and large values of the scaling parameter by an appropriate time-dependent gain parameter, which leads to a faster and bounded convergence of the error function in comparison to previous ZNN methods. The convergence properties of the proposed VPFTZNN dynamical evolution in its generic form is verified. Particularly, VPFTZNN for solving linear matrix equations and for computing generalized inverses are investigated theoretically and numerically. Moreover, the proposed design is applicable in solving the TV matrix inversion problem, solving the Lyapunov and Sylvester equation as well as in approximating the matrix square root. Theoretical analysis as well as simulation results validate the effectiveness of the introduced dynamical evolution. The main advantages of the proposed VPFTZNN dynamics are their generality and faster finite-time convergence with respect to FTZNN models.

The treatment of AL amyloidosis aims to eradicate the plasma cell clone and eliminate toxic free light chain production. Only in a minority of patients the plasma cell clone is completely eradicated; residual light chain production may still exist while clonal relapse may occur. We used sensitive next-generation flow cytometry (NGF) to detect minimal residual disease (MRD) in AL amyloidosis patients at complete haematologic response. MRD evaluation was feasible in 51 of 52 (98{%}) tested patients and at a median sensitivity of 2.3 × 10−6 MRD was undetectable in 23 (45{%}). An organ response occurred in 86{%} of MRDneg vs 77{%} in MRDpos; renal response in 15/17(88{%}) of MRDneg vs in 14/16(87.5{%}) of MRDpos and cardiac response in 10/10(100{%}) of MRDneg vs 11/15(73{%}) of MRDpos patients. After a median follow-up of 24 months post MRD testing, no MRDneg patient had a haematologic relapse vs 6/28(21{%}) MRDpos (p =.029). Pooling haematologic and organ progressions, 9 (32{%}) MRDpos patients had disease progression vs only 1 (4{%}) MRDneg patient (p =.026). In conclusion, MRD detection using NGF has profound clinical implications, so that AL patients with undetectable MRD have a very high probability of organ response and a very low probability of haematologic relapse.

Following the detection of recent X-ray activity from the Be X-ray binary pulsar 1A 0535+262 on 2020 November 6 (ATel #14157), the Neutron Star Interior Composition Explorer (NICER) has observed the system at multiple epochs.

Following the SRG/eROSITA discovery of a strong outburst from the LMC Be/X-ray binary RX J0529.8-6556 (Haberl et al., ATEL #13828) we triggered NICER ToO observations to search for pulsations and obtain high-quality spectra.

In their paper in Optica 6, 104 (2019), Mann et al. claim that linear, time-invariant nonreciprocal structures cannot overcome the time-bandwidth limit and do not exhibit an advantage over their reciprocal counterparts, specifically with regard to their time-bandwidth performance. In this Comment, we argue that these conclusions are unfounded. On the basis of both rigorous full-wave simulations and insightful physical justifications, we explain that the temporal coupled-mode theory, on which Mann et al. base their main conclusions, is not suited for the study of nonreciprocal trapped states, and instead direct numerical solutions of Maxwell’s equations are required. Based on such an analysis, we show that a nonreciprocal terminated waveguide, resulting in a trapped state, clearly outperforms its reciprocal counterpart; i.e., both the extraordinary time-bandwidth performance and the large field enhancements observed in such modes are a direct consequence of nonreciprocity. © 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

Trans-crocin 4 (TC4) is an important carotenoid constituent of saffron showing potential activity against Alzheimer's Disease (AD) due to its antioxidant and antiamyloidogenic properties. Metabolomics is an emerging scientific field that enhances biomarker discovery and reveals underlying biochemical mechanisms aiming towards the early subclinical diagnosis of diseases. To date, there are no reports on the changes induced to mice plasma metabolome after TC4 administration. We report a novel untargeted UHPLC-ESI HRMS metabolomics strategy to determine the alteration of the metabolic fingerprint following i.p. administration of TC4 in male and female mice. Blood samples from fiftysix mice treated with TC4 as well as from control animals were analyzed with UHPLC-ESI HRMS. Statistical evaluation of the results was achieved by multivariate analysis (MVA), i.e., principal component analysis (PCA), Partial Least Squares-Discriminant Analysis (PLS-DA) in order to discover the variables that contributed to the discrimination between treated and untreated groups which were identified by online database searching (e.g., Metlin, HMDB, KEGG) aided by chemometric processing, e.g., covariance searching etc. Due to the high variability imposed by various factors, e.g., sex of the animals participating in the study, administration dose and time-points of sacrifice, multilevel sparse PLS-DA analysis, e.g., splitting variation to each individual component, has been employed as a more efficient approach for such designs. This methodology allowed the identification of the time sequence of metabolome changes due to the administration of TC4, whereas a sex-related effect on the metabolome is indicated, denoting that the administration in both sexes is indispensable in order to acquire safe conclusions as reliable metabolome pictures. The results demonstrated a number of annotated metabolites playing a potential role in neuroprotection while they are closely related to AD. Moreover, five additional annotated metabolites were involved in the steroid biosynthesis pathway while two of them may be considered as putative neuroprotective agents.

Trans-crocin 4 (TC4) is an important carotenoid constituent of saffron showing potential activity against Alzheimer's Disease (AD) due to its antioxidant and antiamyloidogenic properties. Metabolomics is an emerging scientific field that enhances biomarker discovery and reveals underlying biochemical mechanisms aiming towards the early subclinical diagnosis of diseases. To date, there are no reports on the changes induced to mice plasma metabolome after TC4 administration. We report a novel untargeted UHPLC-ESI HRMS metabolomics strategy to determine the alteration of the metabolic fingerprint following i.p. administration of TC4 in male and female mice. Blood samples from fiftysix mice treated with TC4 as well as from control animals were analyzed with UHPLC-ESI HRMS. Statistical evaluation of the results was achieved by multivariate analysis (MVA), i.e., principal component analysis (PCA), Partial Least Squares-Discriminant Analysis (PLS-DA) in order to discover the variables that contributed to the discrimination between treated and untreated groups which were identified by online database searching (e.g., Metlin, HMDB, KEGG) aided by chemometric processing, e.g., covariance searching etc. Due to the high variability imposed by various factors, e.g., sex of the animals participating in the study, administration dose and time-points of sacrifice, multilevel sparse PLS-DA analysis, e.g., splitting variation to each individual component, has been employed as a more efficient approach for such designs. This methodology allowed the identification of the time sequence of metabolome changes due to the administration of TC4, whereas a sex-related effect on the metabolome is indicated, denoting that the administration in both sexes is indispensable in order to acquire safe conclusions as reliable metabolome pictures. The results demonstrated a number of annotated metabolites playing a potential role in neuroprotection while they are closely related to AD. Moreover, five additional annotated metabolites were involved in the steroid biosynthesis pathway while two of them may be considered as putative neuroprotective agents.

Recent modeling of Neutron Star Interior Composition Explorer (NICER) observations of the millisecond pulsar PSR J0030+0451 suggests that the magnetic field of the pulsar is non-dipolar. We construct a magnetic field configuration where foot points of the open field lines closely resemble the hotspot configuration from NICER observations. Using this magnetic field as input, we perform force-free simulations of the magnetosphere of PSR J0030+0451, showing the three-dimensional structure of its plasma-filled magnetosphere. Making simple and physically motivated assumptions about the emitting regions, we are able to construct the multiwavelength lightcurves that qualitatively agree with the corresponding observations. The agreement suggests that multipole magnetic structures are the key to modeling this type of pulsar, and can be used to constrain the magnetic inclination angle and the location of radio emission.

The computational study of x-pinch plasmas driven by pulsed power generators demands the development of advanced numerical models and simulation schemes, able to enlighten the experiments. The capabilities of PLUTO code are here extended to enable the investigation of low current produced x-pinch plasmas. The numerical modules of the code used and modified are presented and discussed. The simulations results are compared to experiments, carried out on a table-top pulsed power plasma generator implemented in a mode of producing a peak current of ∼45 kA with a rise time (10%-90%) of 50 ns, loaded with Tungsten wires. The structural evolution of plasma density is studied and its influence on the magnetic field is analyzed with the help of the new simulation data. The simulated areal mass density is compared with the experimentally measured dense opaque region to enlighten the dense plasma evolution. In addition, the measured areal electron density is compared to the simulation results. Moreover, the new simulation data offer valuable insights to the main jet formation mechanisms, which are further analyzed and discussed in relation to the influence of the J× B force and the momentum.

The computational study of x-pinch plasmas driven by pulsed power generators demands the development of advanced numerical models and simulation schemes, able to enlighten the experiments. The capabilities of PLUTO code are here extended to enable the investigation of low current produced x-pinch plasmas. The numerical modules of the code used and modified are presented and discussed. The simulations results are compared to experiments, carried out on a table-top pulsed power plasma generator implemented in a mode of producing a peak current of ∼45 kA with a rise time (10%-90%) of 50 ns, loaded with Tungsten wires. The structural evolution of plasma density is studied and its influence on the magnetic field is analyzed with the help of the new simulation data. The simulated areal mass density is compared with the experimentally measured dense opaque region to enlighten the dense plasma evolution. In addition, the measured areal electron density is compared to the simulation results. Moreover, the new simulation data offer valuable insights to the main jet formation mechanisms, which are further analyzed and discussed in relation to the influence of the J× B force and the momentum.

Aims: Spectral and temporal analysis of the NuSTAR observation Galactic Be-XRB Swift J1845.7-0037. during its recent outburst. Methods: For the spectral analysis we use both phenomenological and physics-based models. We employ an often used empirical model to identify the main characteristics of the spectral shape in relation to nominal spectral characteristics of X-ray pulsars. Additionally, we used the latest version of Bulk amp; Thermal comptonization model (BW), to assess the validity of the spectral components required by the empirical model and to investigate the origin of the hard X-ray emission. We also analyzed the source light-curve, studying the pulse shape at different energy ranges and tracking the spectral evolution with pulse phase by using the model independent hardness ratio (HR). Results: We find that while both the empirical and physical (BW) spectral models can produce good spectral fits, the BW model returns physically plausible best-fit values for the source parameters and does not require any additional spectral components to the non-thermal, accretion column emission. The BW model also yielded an estimation of the neutron star magnetic field placing it in the 10^12G range. Conclusions: Our results, show that the spectral and temporal characteristics of the source emission are consistent with the scattering processes expected for radiation dominated shocks within the accretion column of highly magnetized accreting neutron stars. We further indicate that physically-derived spectral models such as BW, can be used to tentatively infer fundamental source parameters, in the absence of more direct observational signatures.

«O scriere a lui Sevastos Kyminitis adresată Voievodului Constantin Basarab», Relevanța Bisericii Ortodoxe în cultura română: interferenţe interortodoxe şi intercreştine, Facultatea de Teologie Ortodoxă “Ilarion V. Felea” Arad, Editura Universității “Aurel Vlaicu”, Arad - Editura Universitaria, Craiova, 2020, p. 45-56 (Romanian language) //  « Ἕνα ἰδιόρυθμο “Κάτοπτρο Ἡγεμόνος” τοῦ Σεβαστου Κυμηνίτου γιὰ τὸν Constantin Basarab», Relevanța Bisericii Ortodoxe în cultura română: interferenţe interortodoxe şi intercreştine, Facultatea de Teologie Ortodoxă “Ilarion V. Felea” Arad, Editura Universității “Aurel Vlaicu”, Arad - Editura Universitaria, Craiova, 2020, p. 45-56

The increased development of computer vision technology combined with the increased availability of innovative platforms with ultra-high-resolution sensors, has generated new opportunities and fields for investigation in the engineering geology domain in general and landslide identification and characterization in particular. During the last decade, the so-called Unmanned Aerial Vehicles (UAVs) have been evaluated for diverse applications such as 3D terrain analysis, slope stability, mass movement hazard and risk management. Their advantages of detailed data acquisition at a low cost and effective performance identifies them as leading platforms for site-specific 3D modelling. In this study, the proposed methodology has been developed based on Object-Based Image Analysis (OBIA) and fusion of multivariate data resulted from UAV photogrammetry processing in order to take full advantage of the produced data. Two landslide case studies within the territory of Greece, with different geological and geomorphological characteristics, have been investigated in order to assess the developed landslide detection and characterization algorithm performance in distinct scenarios. The methodology outputs demonstrate the potential for an accurate characterization of individual landslide objects within this natural process based on ultra high-resolution data from close range photogrammetry and OBIA techniques for landslide conceptualization. This proposed study shows that UAV-based landslide modelling on the specific case sites provides a detailed characterization of local scale events in an automated sense with high adaptability on the specific case site.

In this paper, for the first time in literature, we introduce one-sided weighted inverses and extend the notions of one-sided inverses, outer inverses and inverses along given elements. Although our results are new and in the matrix case, we decided to present them in tensor space with reshape operator. For this purpose, a left and right (M,N)-weighted (B,C)-inverse and the (M,N)-weighted (B,C)-inverse of a tensor are defined. Additionally, necessary and sufficient conditions for the existence of these new inverses are presented. We describe the sets of all left (or right) (M,N)-weighted (B,C)-inverses of a given tensor. As consequences of these results, we consider the one-sided (B,C)-inverse, (B,C)-inverse, one-sided inverse along a tensor and inverse along a tensor. Further, we introduce a (M,N)-weighted (B,C)-outer inverse and a W-weighted (B,C)-outer inverse of tensors with a few characterizations. Then, corresponding algorithms for computing various types of outer inverses of tensors are proposed, implemented and tested. The prowess of the proposed inverses are demonstrated for finding the solution of Poisson problem and the restoration of 3D color images.

Chemical study of the CH2Cl2−MeOH (1:1) extract from the sponge Haliclona sp. collected in Mayotte highlighted three new long-chain highly oxygenated polyacetylenes, osirisynes G-I (1–3) together with the known osirisynes A (4), B (5), and E (6). Their structures were elucidated by 1D and 2D NMR spectra and HRESIMS and MS/MS data. All compounds were evaluated on catalase and sirtuin 1 activation and on CDK7, proteasome, Fyn kinase, tyrosinase, and elastase inhibition. Five compounds (1; 3–6) inhibited proteasome kinase and two compounds (5–6) inhibited CDK7 and Fyn kinase. Osirisyne B (5) was the most active compound with IC50 on FYNB kinase, CDK7 kinase, and proteasome inhibition of 18.44 µM, 9.13 µM, and 0.26 µM, respectively.

The spatial and temporal scale of flash flood occurrence provides limited opportunities for observations and measurements using conventional monitoring networks, turning the focus to event-based, post-disaster studies. Post-flood surveys exploit field evidence to make indirect discharge estimations, aiming to improve our understanding of hydrological response dynamics under extreme meteorological forcing. However, discharge estimations are associated with demanding fieldwork aiming to record in small timeframes delicate data and data prone-to-be-lost and achieve the desired accuracy in measurements to minimize various uncertainties of the process. In this work, we explore the potential of unmanned aerial systems (UAS) technology, in combination with the Structure for Motion (SfM) and optical granulometry techniques in peak discharge estimations. We compare the results of the UAS-aided discharge estimations to estimates derived from differential Global Navigation Satellite System (d-GNSS) surveys and hydrologic modelling. The application in the catchment of Soures torrent in Greece, after a catastrophic flood shows that the UAS-aided approach succeeded in determining peak discharge with high accuracy. The technique proved to be particularly effective, providing flexibility in terms of resources and timing, although there are certain limitations to its applicability. The application highlighted important advantages and certain weaknesses of these emerging tools in indirect discharge estimations, which we discuss in detail.

Hymnale Ambrosianum. The structural background of a paleochristian hymnological modelThe monograph covers exhaustively all aspects of the structural material of Ambrose’s hymnological prototype. Given that the locating of the structural material is identified with its semiological understanding in the researcher’s language, the translation-related elaboration of the texts could not be excluded from this study.At its beginning the book comprises: the Table of Contents (pp. 9- 11), the Foreword (pp. 13-14) and Abbreviations (pp. 15-19). The following parts are: 1. Introduction (pp. 21-65). The first paragraph entitled Foreword (pp. 22-30), focuses on the significance of Ambrose’s Hymnologion. It focuses on the fourteen authentic hymns by Ambrose, as an aspect constituting common knowledge in the two ancient liturgical traditions, those of West and East. The next paragraph is entitled References of the Research of Ambrose’s Hymnology (pp. 30-39), which is a presentation of hitherto literary studies and publications of Ambrose’s Hymnologion with critical observations. The title of the next paragraph is The Hard to Explore Structural Dimension of Hymnale Ambrosianum (pp. 39-47). This paragraph locates the gaps in the research of Ambrose’s hymnography as a spiritual creation. It does this through the prism of the question of whether as a prototype of the hymnological development Ambrose’s hymnography fits within the structural basis of the treasury of the tradition of worship of the Church universally and whether, as such, it could point to a desirable balance between the creative freedom and the required adherence to the treasury of the Holy Tradition of worship. The fourth paragraph is entitled The Translational Gap of Ambrose’s Hymns in Greek Bibliography (pp. 47-62). The fifth and last paragraph entitled The Translational Approach of the Present Publication (pp. 62-65) is divided into three subsections: the ad litteram translation (literal, word by word translation), the ad sensum translation (translation according to meaning) and lastly, the translations where Latin alphabet is used for writing in Greek. 2. Chapter I (pp. 67-154) entitled The Ambrosian Context is divided into two parts. The first part, entitled The Mystic and Teacher (pp. 67-90), offers a portrayal of Ambrose while focusing on the aspects that are significant for the topic of the present study. The second part, entitled Divine Mystagogy (pp. 90-154) deals with the three basic components of Ambrose’s pedagogy: (a) the fishing of souls through preaching (liturgical Evangelism), (b) the passing on of the Eucharistic theology and its embrace by the faithful and (c) the formation of an appealing and complete prototype of the mystagogical performance. These three components place the regular presence of the faithful inside the Church and the creation of a live, participation-loving and zealously pulsating community at the epicentre of Ambrose’s pastoral aim. 3. Chapter II (pp. 155-179) bears the title The Dogmatic Reading of Ambrose’s Hymns. This chapter is divided into two parts. The first part is entitled Confession of Faith (pp. 155-170), whereas the second part is entitled Confession of Martyrdom (pp. 170-179). In the first part, the commentary on the Nicene-Constantinopolitan Creed with verses from Ambrose’s hymns demonstrates that Ambrose’s hymns are a vehicle for transmitting and consolidating of the foundational dogmas of orthodoxy. In the second part, we make use of the translations included in the publication part of this study (ad litteram, ad sensum and 19th century Greek texts with Latin characters) in order to demonstrate Ambrose’s position in relation to those dogmatic teachings which are not included in the Nicene-Constantinopolitan Creed. The main axis of that second part of Chapter II is the teaching regarding the Martyrdom. It is upon that teaching that Peter’s primacy is constructed, as a primacy of the Confession of Faith. The equality between Peter and Paul in terms of the Martyrdom, the honouring of the memory of the Martyrs by the Church and the veneration of their relics by the faithful within the context of Divine Worship are aspects which are also established. 4. Chapter III (pp. 181-230) is entitled Ambrose’s Hymnological Prototype. The Introduction (pp. 181-188) is followed by the section entitled Melopoetic and Performative Method (pp. 188-212), where within three separate paragraphs, three prototypes of the hymnological development are presented and analysed, based on the research sources. These prototypes are presented and analysed according to the chronological order of the epochs to which they belong and not according to the epoch of the source’s writer. More specifically, these are: the prototype of Antiochians Flavian and Diodoros, the prototype of Ambrose and the prototype of Chrysostom. In the fourth paragraph a common historical provenance of these three prototypes is located. The similarity between Ambrose’s prototype and other prototypes which are collectively of Eastern provenance provides an answer to the crucial question posed in the Introduction, meaning that Ambrose’s is a prototype of hymnological development which fits within the structural basis of the treasury of worship of the entire Church. The third part of Chapter III bears the title Poetic Art (pp. 213-230) and it relates to the idiosyncratic aspect of Ambrose’s poetic art, which was imitated by later hymnographers of the Western Church. The monograph locates these aspects and includes them by paying attention to that which is particular as distinct to that which is general. It does this while paying attention to the simplicity of the texts, the density of the narrative meanings and the dominating lyricism. Accordingly, the monograph conducts the analysis of the content of the sources which is arranged into three subsections with following titles: The Oikonomia of the Depicting Word (pp. 213-219), The Perspective of the Verbal Image (pp. 219-227) and Ambrose’s Lyrical State (pp. 227-230). The last part of the monograph is the publication part (pp. 233-319) which includes: (a) the threefold publication of the text of the fourteen authentic Ambrosian Hymns (the Latin original, the Greek ad litteram translation and the Greek ad sensum translation), (b) the publication of the Latin original and the equivalent Greek text with Latin characters of five hymns which have been attributed to Ambrose in the past and which fit within the broader category of imitations of Hymnale Ambrosianum - the texts confirm the position supported in this monograph, that Ambrose’s orthodoxy was crystal clear and undeniable and that his status was such that translators who re-wrote hymns in Greek with Latin characters which were considered Ambrosian respected their dogmatic precision, (c) the publication of one hymn in Latin and its equivalent Greek text with Latin characters which was never attributed to Ambrose and which, contrary to the category of translated hymns mentioned in point ‘b’, manifests serious dogmatic alterations which occurred during the translation from Latin to Greek, despite the fact that its prototype does not deviate from the orthodox dogma. The Abstract in English is then included, followed by the Bibliography, the Translation Index, the Index of Excerpts from the Bible, the Index of Names and the Index of Terms

Restrictions on exercising worship can be applied for the protection of hunan life  and health during pandemic crisis  by the power of the 88th Canon of the Penthekti Ecumenical Synods (In Trullo, 691).The Holy Canon introduces a  general principle within the postitive law of the Church. It is described as the principle of apatheia:  "And we are taught that the Sabbath was made for man: wherefore also the safety and comfort of man are by all means to be placed first."

Swift J0243.6+6124 is a Be/X-ray binary and the first known ultraluminous X-ray pulsar in our Galaxy that reached a peak luminosity Lx > 1039 erg s-1 during its 2017-2018 outburst. The proximity of this system allows for the study of super-Eddington accretion as an analog of distant ultraluminous X-ray sources. We used data from the Neil Gehrels Swift X-ray Telescope to investigate the evolution of the spectral and temporal properties of this system, looking for characteristic transitions that could reveal changes in the accretion regime with Lx. A first transition is found in the hardness-intensity diagram at Lx ~ 7 x 1036 erg s-1. The system exhibits a harder-when-brighter trend that changes to a softer-when-brighter trend. This transition is typical in Galactic BeXRB pulsars, and is often used as a proxy of the magnetic field strength of the neutron star. A second transition is indicated by changes in fractional variability and spectral hardness at a critical luminosity Lcrit ~ 3 x 1038 erg s-1. Pulsations exhibit single peak behavior and change to double peak following the transition. Associating these transitions with the formation and evolution of the accretion column can help us derive constraints on the magnetic field of the neutron star, and gain insights on super-Eddington accretion.

Background:Although several studies that rely on self-determinationtheory have shown the positive interrelations among perceived needsupportive  learning  environment,  needs  satisfaction,  quality  ofmotivation, and desired outcomes in the context of physical education,only few studies have tested so far the full sequence of relations withina single integrated model.Purpose:The main aim of this study was to test whether indeed needssatisfaction and in turn quality of motivation mediate the relations ofneed supportive learning environment to physical activity engagementand intentions.Method:Participants were 1120 Spanish students (49.9% males;Mage =11.70 years;SD= 1.63; range = 10–17 years) from 30 classes out of 13primary and secondary schools.Results:The multilevel path model showed a positive relation ofperceived need-supportive teaching to physical activity engagementand intentions by means of needs satisfaction and autonomousmotivation  and  a  negative  relation  of  perceived  need-thwartingteaching to engagement and intentions by means of needs frustrationand  amotivation.  Although  controlled  motivation  was  found  toassociate with need frustration and need-thwarting teaching it was notassociated with engagement and intentions.Conclusion:the presentfindings suggest that the type of teaching styleemployed by the teachers is decisive to achieve positive consequences inphysical education students.

Recent developments in digital technologies regarding the cultural heritage domain have driven technological trends in comfortable and convenient traveling, by offering interactive and personalized user experiences. The emergence of big data analytics, recommendation systems and personalization techniques have created a smart research field, augmenting cultural heritage visitor’s experience. In this work, a novel, hybrid recommender system for cultural places is proposed, that combines user preference with cultural tourist typologies. Starting with the McKercher typology as a user classification research base, which extracts five categories of heritage tourists out of two variables (cultural centrality and depth of user experience) and using a questionnaire, an enriched cultural tourist typology is developed, where three additional variables governing cultural visitor types are also proposed (frequency of visits, visiting knowledge and duration of the visit). The extracted categories per user are fused in a robust collaborative filtering, matrix factorization-based recommendation algorithm as extra user features. The obtained results on reference data collected from eight cities exhibit an improvement in system performance, thereby indicating the robustness of the presented approach.

Triassic rift-related volcanic rocks outcrop over all mainland Greece, comprising of trachybasalts and basaltic trachyandesites. Relatively immobile to the effects of alteration processes major and trace element abundances classify the volcanics into OIB and E-MORB lavas. They have mainly been distinguished based upon their: i) LREE contents, ii) silica-saturation index (S·I.), iii) Zr/Nb and Nb/Y ratio values; iv) Th, U, and Ta contents v) geotectonic discrimination diagrams. Their geochemistry indicates that most rocks were affected by moderate to extensive differentiation processes, mostly expressed by clinopyroxene fractionation. Some of the OIB and E-MORB volcanics are considered as primitive undersaturated, displaying (low SiO2, Zr/Nb and S.I. values, enhanced CaO/Al2O3 ratios). Calculated average mantle potential temperatures are comparable (1410 °C OIB; 1370 °C E-MORB), with melt fractions estimated at 3–5% for primary OIB magmas and 6–8% for primary E-MORB magmas. An asthenospheric origin is inferred for the OIB lavas, with melting in the garnet stability field (75–95 km; 2.5–3.0 GPa), whereas E-MORB parent magmas were formed with melting in the garnet/spinel (transitional) stability field (55–70 km; 1.8–2.2 GPa). The Hellenic Triassic rift-related lavas were most likely generated and erupted after lithospheric attenuation and extension, followed by subsequent asthenospheric upwelling of the mantle. The high calculated partial melting degrees and the observed thick and voluminous lava formations account for fast-spreading of the Tethys ridge during the Triassic. Temperature results suggest that the Hellenic Triassic rift-related magmas were generated from mantle at ambient temperature, render a mantle plume-based scenario improbable.

Cepheids are pulsating variable stars with a periodic chromospheric response at UV wavelengths close to their minimum radius phase. Recently, an X-ray variable signature was captured in observations during the maximum radius phase. This X-ray emission came as a surprise and is not understood. In this work, we use the modern astrophysical code PLUTO to investigate the effects of pulsations on Cepheid X-ray emission. We run a number of hydrodynamic numerical simulations with a variety of initial and boundary conditions in order to explore the capability of shocks to produce the observed phase-dependent X-ray behavior. Finally, we use the Simulated Observations of X-ray Sources (SOXS) package to create synthetic spectra for each simulation case and link our simulations to observables. We show that, for certain conditions, we can reproduce observed X-ray fluxes at phases 0.4-0.8 when the Cepheid is at maximum radius. Our results span a wide range of mass-loss rates, 2 × 10-13 M☉ yr-1 to 3 × 10-8 M☉ yr-1, and peak X-ray luminosities, 5 × 10-17 erg cm-2 s-1 to 1.4 × 10-12 erg cm-2 s-1. We conclude that Cepheids exhibit two-component emission with (a) shock waves being responsible for the phase-dependent variable emission (phases 0.2-0.6) and (b) a separate quiescent mechanism being the dominant emission mechanism for the remaining phases.

Cepheids are pulsating variable stars with a periodic chromospheric response at UV wavelengths close to their minimum radius phase. Recently, an X-ray variable signature was captured in observations during the maximum radius phase. This X-ray emission came as a surprise and is not understood. In this work, we use the modern astrophysical code PLUTO to investigate the effects of pulsations on Cepheid X-ray emission. We run a number of hydrodynamic numerical simulations with a variety of initial and boundary conditions in order to explore the capability of shocks to produce the observed phase-dependent X-ray behavior. Finally, we use the Simulated Observations of X-ray Sources (SOXS) package to create synthetic spectra for each simulation case and link our simulations to observables. We show that, for certain conditions, we can reproduce observed X-ray fluxes at phases 0.4-0.8 when the Cepheid is at maximum radius. Our results span a wide range of mass-loss rates, 2 × 10-13 M⊙ yr-1 to 3 × 10-8 M⊙ yr-1, and peak X-ray luminosities, 5 × 10-17 erg cm-2 s-1 to 1.4 × 10-12 erg cm-2 s-1. We conclude that Cepheids exhibit two-component emission with (a) shock waves being responsible for the phase-dependent variable emission (phases 0.2-0.6) and (b) a separate quiescent mechanism being the dominant emission mechanism for the remaining phases.

Assessment of the long-term population-level effects of HIV interventions is an ongoing public health challenge. Following the implementation of a Transmission Reduction Intervention Project (TRIP) in Odessa, Ukraine, in 2013-2016, we obtained HIV pol gene sequences and used phylogenetics to identify HIV transmission clusters. We further applied the birth-death skyline model to the sequences from Odessa (n = 275) and Kyiv (n = 92) in order to estimate changes in the epidemic's effective reproductive number (R(e)) and rate of becoming uninfectious (δ). We identified 12 transmission clusters in Odessa; phylogenetic clustering was correlated with younger age and higher average viral load at the time of sampling. Estimated R(e) were similar in Odessa and Kyiv before the initiation of TRIP; R(e) started to decline in 2013 and is now below R(e) = 1 in Odessa (R(e) = 0.4, 95%HPD 0.06-0.75), but not in Kyiv (R(e) = 2.3, 95%HPD 0.2-5.4). Similarly, estimates of δ increased in Odessa after the initiation of TRIP. Given that both cities shared the same HIV prevention programs in 2013-2019, apart from TRIP, the observed changes in transmission parameters are likely attributable to the TRIP intervention. We propose that molecular epidemiology analysis can be used as a post-intervention effectiveness assessment tool.

Numerous studies covering some aspects of SARS-CoV-2 data analyses are being published on a daily basis, including a regularly updated phylogeny on nextstrain.org. Here, we review the difficulties of inferring reliable phylogenies by example of a data snapshot comprising a quality-filtered subset of 8, 736 out of all 16, 453 virus sequences available on May 5, 2020 from gisaid.org. We find that it is difficult to infer a reliable phylogeny on these data due to the large number of sequences in conjunction with the low number of mutations. We further find that rooting the inferred phylogeny with some degree of confidence either via the bat and pangolin outgroups or by applying novel computational methods on the ingroup phylogeny does not appear to be credible. Finally, an automatic classification of the current sequences into sub-classes using the mPTP tool for molecular species delimitation is also, as might be expected, not possible, as the sequences are too closely related. We conclude that, although the application of phylogenetic methods to disentangle the evolution and spread of COVID-19 provides some insight, results of phylogenetic analyses, in particular those conducted under the default settings of current phylogenetic inference tools, as well as downstream analyses on the inferred phylogenies, should be considered and interpreted with extreme caution.

According to Piaget, the attainment of formal operational thought (between the ages of 12 and 15 years) is the final stage of cognitive development, preparing the adolescent to efficiently adapt to the adult world. Piaget regarded formal thinking as propositional, abstract, hypothetico-deductive, combinatory, and reflective, allowing for the conception of both the possible and the real. This entry discusses the fundamental mechanisms that lead to the acquisition of formal thought, along with its specific manifestations. Finally, it presents an overview of the criticism of the Piagetian theoretical standpoint.

A generalized rigorous Floquet scattering-matrix method for stratified anisotropic optical media, subject to a periodic spatiotemporal modulation, is formulated and implemented. The method is applied for studying an optomagnonic cavity formed by an in-plane magnetized ferrite film, in which a magnetostatic surface spin wave propagates, sandwiched between two nonmagnetic dielectric Bragg mirrors. Our results provide unambiguous evidence that externally incident light, when trapped in a cavity mode, experiences a strongly enhanced interaction with the spin wave due to the increased coupling time, which can give rise to pronounced effects if the appropriate selection rules are fulfilled. By means of systematic calculations we reveal and explain some remarkable features of this interaction, such as formation of spectral gaps, controllable transmission, and the emergence of inelastic diffracted beams, and show that efficient conversion of the optical wave can be achieved by triply resonant inelastic scattering through (multi)magnon absorption and emission processes.

Planets In Your Hand is a science education program, that consists of a portable interactive exhibition of eight planetary surface models. The program offers the visitors a tactile experience and the opportunity to understand the diversity of the planetary surfaces in our Solar System. The planetary models have been exhibited in a series of public events since their construction in 2018 and have been visited by a wide range of audience, including visually impaired people. The project is still running, while Planets In Your Hand team is working on improvements, that foresee to a greater social and educational impact. The current work summarizes the social impact of the program through the visitors" questionnaires, comments and impressions.1. IntroductionPlanets In Your Hand (PIYH) is a science communication project, initiated at the Department of Physics of National and Kapodistrian University of Athens (NKUA). Its purpose is to reach individuals, that do not have any previous interaction with the field, trigger their interest to interactively participate in scientific activities and public events and eventually bring them closer to science and contribute in lifelong learning. This is mainly attempted through a visual and tangible representation of the planetary environments and morphologies in our Solar System (Kefala et al., 2018), that also benefits visually impaired people.The success of PIYH project is established by the Science Communication Award (EΠI2 Award 2019) in the category of "Awareness Activities and Campaigns".PIYH program is a non-formal learning experience, the importance of which is widely accepted and supported by the National Science Education Standards (National Research Council, 1996). The way science communication is organized and planned as well as the visitor"s intrinsic motivation for learning (Eshach 2007) declares this an indisputable fact.2. Data CollectionIn order to evaluate the social impact of the PIYH project, questionnaires were filled out by the visitors after their conceivable journey to our Solar System. Multiple-choice questions and a comment section were included. The goal was to examine whether the exhibition provides an overall positive experience to the visitors and to find possible ways to improve its presentation.The planetary models have been exhibited in a series of public events (Fig. 1) since the beginning of the program (Palafouta et al., 2019). This research was conducted during two major events where PIYH was presented. These are the opening of the exhibition and the Athens Science Festival 2019.Oral impressions and evaluations for every event were also made directly by the members of the PIYH team that presented the planetary surfaces. They were based on the reactions and the comments of the visitors and were really helpful. PIYH program is a non-formal learning experience, the importance of which is widely accepted and supported by the National Science Education Standards (National Research Council, 1996). The way science communication is organized and planned as well as the visitor"s intrinsic motivation for learning (Eshach 2007) declares this an indisputable fact.3. The social impactThe questionnaire provided an overall positive feedback by the visitors. As shown in Fig. 2 the majority (97.5 %) of the visitors were pleased with PIYH project and the exhibition. Early ages (≤23 years old) occupy great percentage (61 %) of the visitors, while the rest include individuals, parents or educators.The overwhelming majority of the participants (98.5%) would recommend the exhibition to a friend, enhancing the social impact of the project, while many parents and educators mentioned that this project can trigger new generations to engage with Astrophysics and science in general.More than 47% of the visitors shared their impressions through additional comments. Positive remarks were given, for the exhibition and its presentation by the PIYH team members.Visually impaired people commented positively, mentioning that exhibitions in general do not offer tangible experience, and they are limited to an oral, acoustic or pre-recorded presentation. PIYH exhibition gave them for the first time the sense of planetary scale, surface characteristics and the unique opportunity to interact with planetary surfaces.A wide range of reactions was perceived by the PIYH team members during the events with respect to the visitor"s background in astrophysics.Regardless of their age, people who were getting in touch with Planetary Science for the first time were curious to touch and feel the surface"s differences, asking questions about the internal and external structure and the atmospheric phenomena of each planet. Those who had scientific background, combined facts and knowledge from their own scientific field with the information provided during the events.On the other hand, visitors familiar with astronomy and planetary science expressed more elaborate questions, many of which concerned the current research on space exploration.4. Summary and ConclusionsThis research has shown that people of different age and scientific background can be brought together through an interactive and tangible educational experience. PIYH exhibition is considered a pleasant and memorable experience according to the conducted analysis. The project attracted individuals that have no previous interaction with the field of Planetary Science, triggering their interest and brought together people who are already interested or contribute to science. PIYH project makes this learning experience accessible to visually impaired people, encouraging this way the local community to create similar activities. It is an alternative, creative and interesting way of learning about our Solar System. Similar projects can be inspired by PIYH program and engage the general public in science through a pleasant and cognitively successful way, enhancing the communication of science in many fields.References[1] Eshach, H., 2007, Journal of Science Education and Technology, 16, 171-190.[2] Kefala, K., et al., 2018, EPSC2018,1251-2.[3] National Research Council, 1996.National Science Education Standards. Washington DC: National Academy Press.[4] Palafouta, S., et al., 2019, EPSC-DPS2019, 1816-1

W Ursae Majoris-type binaries belong to the old population of our Galaxy, while their metallicity is close to solar. Their physical properties, kinematics and spatial distribution reflect the properties of their stellar progenitors. This study focuses on the spatial distribution of W UMa's in our solar neighborhood within a 500 pc radius, with a combined astrometric, photometric and spectroscopic determination of their stellar parameters. The sample is carefully selected, in order to fulfill certain criteria, and has well defined metallicity and distance parameters. H-R diagram, as well as similar correlation plots (mass-radius and mass-luminosity), show that the primary (more massive) components in such systems are located close or below the ZAMS region, while secondary components seem to be evolved, as a result of their common envelope geometry. Some prominent outliers are carefully examined in order to judge the environmental properties and evolution in certain locations of the Milky Way. It is found that metallicity is not correlated with distance, but there is a weak correlation between metallicity [M/H] and evolution state, as it is expressed by the location of the systems in the H-R diagram, the type of binary (A or W), and temperature.

During the period 24-25 November 2019 a low pressure system with organised convective storms has affected Greece as it crossed the country from west to east. The system, which was name Gyrionis, after a name used in the Greek mythology, has produced heavy rainfall, with increased lightning activity and local hailstorms. In the area of western Attica the maximum rainfall has been reported with 92 mm of on 24 November and additional 115 mm in 25 November, adding to a storm total of 206 mm, which caused flash floods in the town of Kineta. The storm caused overflowing of local torrents draining the south slopes of Geraneia Ori, inducing significant damages in property and infrastructure mainly within the town and across the coastal zone. Field surveys showed that a wildfire that burned through almost the entire catchment of the main torrent (named Pikas) on 2018, played a crucial role in flooding and its impact on the town. At critical locations along the river, vegetation debris and eroded material of various grain sizes, including boulders, diminished dramatically the hydraulic capacity of the river, intensifying flooding in the downstream areas, which formed an alluvial fan. Based on comparison of pre- and post-flood aerial photography of the burned area, a major source of this deposited material was identified as burned trees still standing after the fire, uprooted from the river banks of the main channel and carried away together with additional soil debris. The material was jammed at a crucial location near the apex of the alluvial fan causing floodwaters to overflow and inundate significant parts of the fan’s apron, a geomorphological setting that increased the extent and impact of flooding further. Overall, the case of Kineta, is a characteristic case of post-wildfire flash flooding, in which the fire effects are critical in the enhancement of subsequent flooding phenomena.

Marathon Lake is an artificial reservoir with great environmental, ecological, social, and economic significance because it was the main source of water for Athens, the capital of Greece, for many years. The present study details the first attempt to map sedimentation in Marathon Lake in detail, using bathymetric mapping and soil erosion field surveying of the torrent watershed areas. First, the results of a bathymetric survey carried out in 2011 were compared with topographic maps that pre-date the construction of the dam. Based on this comparison, an estimated 8.34 hm3 of sediment have been deposited in the 80 years since the dam’s construction. In the current survey, the Revised Universal Soil Loss Equation (RUSLE) was used to estimate soil loss in the watershed area of the streams that end in Marathon Lake. The estimated value from the RUSLE was substantially lower (3.02 hm3) than that calculated in the bathymetric survey.

The so-called "primordial family", is a recently discovered collisional family [1] that could be as old as the Solar system. It contains low-albedo asteroids and is located in the inner Main Belt. This family was identified by the V-shape technique [2] and is estimated to be at least 4 Gyr old, meaning that occurred before the giant planet instability [3]. Asteroids 2768 Gorky (1972 RX3) and 9086 (1995 SA3) are members of the primordial family and have been observed in order to determine their rotational period, spin pole and shape, which will give insights about their membership and the family evolution. The photometric data are obtained mainly by the University of Athens Observatory (UOAO) [4]. Models of the asteroids are derived by the lightcurve inversion method, which is stored in the Database of Asteroid Models from Inversion Techniques (DAMIT) [5].1. IntroductionThe so-called primordial family formed by an impact event 4 Gyr ago or even earlier, i.e. before the giant planet instability [3]. The identification of the primordial family has been done by using the V-shape technique [2]. The V-shape in (α,1/D) space is occurred due to the thermal Yarkovsky effect [6, 7, 2], where prograde-rotating asteroids drifting outwards and retrograde ones inward. As only the inward side of the V-shape of the primordial family is well defined, the members should have retrograde spin. Otherwise, the membership of asteroids with prograde spin could be disputed or the contradicting spin sense could be due to YORP cycles or a collision or a close encounter with other asteroid [8, 9]. Thus, it is essential to observe thoroughly the asteroids belonging to the primordial family, in order to determine their rotational state and shape.2. ObservationsAsteroid 2768 Gorky (1972 RX3) is member of the primordial asteroid family of the inner main belt [1]. Its rotational period is 4.507 ± 0.010 h [10], while its spin pole and shape remain unknown. Observations from Sopot Astronomy Observatory (SAO) for 2 nights in September 2019, in phase angle of 32°, are available in Asteroid Lightcurve Photometry Database (ALCDEF)[11] and present a period of 4.445 ± 0.003 h [12]. On the Observatoire de Genève website of R. Behrend [13] rotational period of the asteroid was reported to be 4.5118 ± 0.0007 h. Asteroid 2768 Gorky (1972 RX3) has been observed from UOAO for 5 nights in December 2019, in phase angles between 10° to 14°.Asteroid 9086 (1995 SA3) is member of the primordial asteroid family in the inner main belt [1]. Its rotational period, spin pole and shape remain unknown. UOAO has been observed this asteroid for 22 nights from October to November 2019, in phase angle ranging between 4° to 22°.3. Methodology and Preliminary ResultsDifferential photometry of the asteroid has been obtained for each sky field. All images were dark and flat-field corrected and unguided. The measured values are in magnitudes and have been transformed properly in relative flux. The determination of the rotational period of the two asteroids and the estimation of the spin pole and shape of 2768 Gorky (1972) has been carried out through the lightcurve inversion method stored in DAMIT [5]. 3.1 Asteroid 2768 Gorky (1972 RX3) The lightcurve of asteroid 2768 Gorky (1972 RX3) present a low amplitude of ~0.1 mag (or ~0.1 intensity units), as Figure 1 shows. Generating 50 random spin poles as initial input for DAMIT software, the results have the distribution presented in Figure 2. The plot in this figure constrains the possible spin poles of the asteroid, while the χ2 value and the dark facet percentage should have the lowest value. 3.2 Asteroid 9086 (1995 SA3) The lightcurve of asteroid 9086 (1995 SA3) present also a low amplitude of ~ 0.2 mag (or ~0.2 intensity units). The low brightness of the object in combination with the low amplitude of its lightcurve render the detection of its periodicity difficult, due to the background noise. In order to address this problem, the exposures of each night were combined in packs of 3, in order to increase the S/N and make the detection of light variation more prominent. The resulted period spectrum from DAMIT is presenting in Figure 3. 4. Summary and Conclusions The rotational period of 2768 Gorky (1972 RX3) has been calculated as 4.510 ± 0.020 h, in agreement with the literature. The spin pole is not defined well enough. It is needed observations from more than one apparition for more robust results. Asteroid 9086 (1995 SA3), despite the extensive observations, does not present a clear lightcurve, as a result to have not unique solution in the period. 5. Further work The determination of asteroids" rotational state and shape requires observations from more than one apparition. Alternatively, combing the already ground based with sparse data from sky surveys or space-borne could also drive to unique solutions. Acknowledgements We would to acknowledge Dr. Hanus J. for his valuable help and advices for the lightcurve analysis that performed. References [1] Delbo, M. et al. (2017). Science, 357, 1026-1029. [2] Bolin, B. T. et al. (2017). Icarus, 282, 290-312. [3] Tsiganis, K., et al. (2005). Nature, 435(7041), 459-461. [4] Gazeas, K. (2016). Revista Mexicana de Astronomía y Astrofísica, 48, 22-23. [5] Ďurech, J. et al. (2010). Astronomy & Astrophysics, 513, A46. (DAMIT"s website: astro.troja.mff.cuni.cz) [6] Milani, A. et al. (2014). Icarus, 239, 46-73. [7] Spoto, F. et al. (2015). Icarus, 257, 275-289. [8] Carruba, V. et al. (2013). Monthly Notices of the Royal Astronomical Society, 433(3), 2075-2096. [9] Delisle, J. B., & Laskar, J. (2012). Astronomy & Astrophysics, 540, A118. [10] Pray, D. P. et al. (2008). Minor Planet Bulletin, 35, 34-36. [11] Asteroid Lightcurve Photometry Database (ALCDEF)"s website: alcdef.org [12] Benishek, V. (2020). Minor Planet Bulletin, 47(1), 75-83. [13] Observatoire de Genève, Website of R. Behrend: obswww.unige.ch/~behrend

© 2019, Hellenic Endocrine Society. Premature ovarian insufficiency (POI) is typically diagnosed when amenorrhea is combined with high gonadotrophins and hypoestrogenemia in a woman under 40 years of age, although, more rarely, POI can develop in adolescence and present with delayed puberty or amenorrhea, depending on the timing of follicular depletion or insult to the ovary. In a proportion of girls, the diagnosis may be made at an early stage of POI, presenting with abnormal uterine bleeding, when some follicular function is still retained. The natural history of POI in this group of patients is not clear; however, they could represent a subgroup with a unique opportunity for early intervention and thus the provision of fertility preservation options. While the etiology of POI in a large number of girls remains unknown, a growing number will be identified as carriers of genetic mutations, offering clinicians a yet greater opportunity to provide genetic counseling to other female family members. The aim of this review is to provide information regarding the etiology, diagnosis, and treatment of POI in adolescents while detailing the new options for fertility preservation when POI is diagnosed at an early stage.