Energy transport within biological systems is critical for biological functions in living cells and for technological applications in molecular motors. Biological systems have very complex dynamics supporting a large number of biochemical and biophysical processes. In the current work, we study the energy transport along protein chains. We examine the influence of different factors such as temperature, salt concentration, and external mechanical drive on the energy flux through protein chains. We obtain that energy fluctuations around the average value for short chains are greater than for longer chains. In addition, the external mechanical load is the most effective agent on bioenergy transport along the studied protein systems. Our results can help design a functional nano-scaled molecular motor based on energy transport along protein chains.

Owing to its highly heterogeneous molecular landscape, bladder cancer (BlCa) is still characterized by non-personalized treatment and lifelong surveillance. Motivated by our previous findings on miR-143/145 value in disease prognosis, we have studied the underlying epigenetic regulation of the miR-143/145 cluster in BlCa. Expression and DNA methylation of miR-143/145 cluster were analyzed in our screening (n = 162) and The Cancer Genome Atlas Urothelial Bladder Carcinoma (TCGA-BLCA; n = 412) cohorts. Survival analysis was performed using tumor relapse and progression as clinical endpoints for non-muscle-invasive bladder cancer (NMIBC; TaT1), while disease progression and patients' death were used for muscle-invasive bladder cancer (MIBC; T2-T4). TCGA-BLCA served as validation cohort. Bootstrap analysis was carried out for internal validation, while decision curve analysis was used to evaluate clinical benefit. TCGA-BLCA and screening cohorts highlighted MIR145 core promoter as the pivotal, epigenetic regulatory region on cluster's expression. Lower methylation of MIR145 core promoter was associated with aggressive disease phenotype, higher risk for NMIBC short-term progression, and poor MIBC survival. MIR145 methylation-fitted multivariate models with established disease markers clearly enhanced patients' risk stratification and prediction of treatment outcome. MIR145 core promoter methylation was identified as a potent epigenetic regulator of miR-143/145 cluster, supporting modern personalized risk stratification and management in BlCa.

Methylation of the fundamental macromolecules, DNA/RNA, and proteins, is remarkably abundant, evolutionarily conserved, and functionally significant in cellular homeostasis and normal tissue/organism development. Disrupted methylation imprinting is strongly linked to loss of the physiological equilibrium and numerous human pathologies, and most importantly to carcinogenesis, tumor heterogeneity, and cancer progression. Mounting recent evidence has documented the active implication of miRNAs in the orchestration of the multicomponent cellular methylation machineries and the deregulation of methylation profile in the epigenetic, epitranscriptomic, and epiproteomic levels during cancer onset and progression. The elucidation of such regulatory networks between the miRNome and the cellular methylation machineries has led to the emergence of a novel subclass of miRNAs, namely "epi-miRNAs" or "epi-miRs." Herein, we have summarized the existing knowledge on the functional role of epi-miRs in the methylation dynamic landscape of human cancers and their clinical utility in modern cancer diagnostics and tailored therapeutics.

Wearable technologies and digital phenotyping foster unique opportunities for designing novel intelligent electronic services that can address various well-being issues in patients with mental disorders (i.e., schizophrenia and bipolar disorder), thus having the potential to revolutionize psychiatry and its clinical practice. In this paper, we present e-Prevention, an innovative integrated system for medical support that facilitates effective monitoring and relapse prevention in patients with mental disorders. The technologies offered through e-Prevention include: (i) long-term continuous recording of biometric and behavioral indices through a smartwatch; (ii) video recordings of patients while being interviewed by a clinician, using a tablet; (iii) automatic and systematic storage of these data in a dedicated Cloud server and; (iv) the ability of relapse detection and prediction. This paper focuses on the description of the e-Prevention system and the methodologies developed for the identification of feature representations that correlate with and can predict psychopathology and relapses in patients with mental disorders. Specifically, we tackle the problem of relapse detection and prediction using Machine and Deep Learning techniques on all collected data. The results are promising, indicating that such predictions could be made and leading eventually to the prediction of psychopathology and the prevention of relapses.

A number of Nature Based Solutions (NBS) are being used around the world in order to address various hydrometeorological hazards as a more environmentally friendly alternative to hard structures. Such a solution has been created in the Spercheios river basin in Central Greece, which is susceptible to heavy rainfall and river bank overflow due to flood water from upstream, in order to mitigate flood and drought impacts under current and future climate conditions. Here a first attempt is made to use actual measurements taken from various sources in the river, including in-situ and satellite data, in order to establish early experimental evidence of the NBS efficiency in the area. The measurements include data from automated hydrological stations from the OpenHi network, satellite remote sensing data and field measurements performed along the Spercheios River basin. For each measurement used, different analysis has been performed based on data availability and pertinence to the NBS efficiency. Preliminary results presented here show that the NBS functions as designed and provides protection against flooding in the area, and can potentially diminish the risk of drought. The results are in agreement with the numerical outputs already presented in our previous work.

This study examines the forecasting performance of the professional analysts participating in the Blue Chip Economic Indicators Survey using an alternative methodological research design. Specifically, we employ a panel specification, which takes into consideration both the time dimension and the forecast horizon, and a quantile regression technique, which evaluates the hidden non-monotonic relations between the forecasts and the target variables being forecasted. Evaluating the accuracy of economic forecasts is critical since they are widely used in financial, investment and policy decision making. Our empirical findings show that survey-based forecasts of interest rates and certain key macroeconomic variables are generally biased, but still efficient predictors of target variables. In particular, we find that survey participants are more efficient in predicting long-term interest rates in the long-run and short-term interest rates in the short-run, while the predictability of medium-term interest rates is the least accurate. Finally, our empirical analysis suggests that currency fluctuations are very hard to predict in the short-run, while we show that survey-based forecasts are among the most accurate predictors of key macroeconomic variables.

Of the 13 known independent zoonoses of simian immunodeficiency viruses to humans, only one, leading to human immunodeficiency virus (HIV) type 1(M) has become pandemic, causing over 80 million human infections. To understand the specific features associated with pandemic human-to-human HIV spread, we compared replication of HIV-1(M) with non-pandemic HIV-(O) and HIV-2 strains in myeloid cell models. We found that non-pandemic HIV lineages replicate less well than HIV-1(M) owing to activation of cGAS and TRIM5-mediated antiviral responses. We applied phylogenetic and X-ray crystallography structural analyses to identify differences between pandemic and non-pandemic HIV capsids. We found that genetic reversal of two specific amino acid adaptations in HIV-1(M) enables activation of TRIM5, cGAS and innate immune responses. We propose a model in which the parental lineage of pandemic HIV-1(M) evolved a capsid that prevents cGAS and TRIM5 triggering, thereby allowing silent replication in myeloid cells. We hypothesize that this capsid adaptation promotes human-to-human spread through avoidance of innate immune response activation.

Degradation of coastal environments is an issue that many areas in Europe are facing. In the present work, an ancient coastal lake wetland is investigated, the so-called Lake Lerna in NE Peloponnese, Greece. The area hosted early agricultural populations of modern Greece that started modifying their environment as early as the early–middle Neolithic. Two drill cores in the area of the ancient lake were analysed to establish the sedimentological succession and the depositional environments using sub-fossil assemblages (molluscs and ostracods). Three lithological and faunal units were recovered, the latter being confirmed by the statistical ordination method (non-metric multidimensional scaling). The usage of sub-fossil mollusc species for the first time in the region enriched the dataset and contributed significantly to the delimitation of the faunas. These consist of environments characterised by various levels of humidity (from stagnant waters to freshwater lake) and salinity, with ephemeral intrusions of salt water to the lake, documented by mollusc and ostracod populations. We conclude that the lake and its included fauna and flora were mostly affected by climatic fluctuations rather than human intervention in the area.

This article explores the influence that an unexpected athletic success can have on the construction of national identity while attempting to answer the question on how such a success can be used as a means to overcome national crises. Using a reflective analysis, this study examines the impact of the Euro 2004 Championship on Greece’s national identity, highlighting the correlation between two events associated with Greekness, to wit national pride and Hellenic identity in the sport, economic and social contexts. The first event was the unpredicted victory of the Greek football team in 2004, thanks to their German coach Otto Rehhagel, and the second Rehhagel’s visit to Athens in March 2013, in his informal role of political mediator, in an attempt to contribute to restoring Greek-German friendship which had been shattered during the country’s period of economic memorandums. This conceptual paper uses a qualitative discourse analysis to explain and understand human action through an examination of media texts and symbolic narratives: the headlines and narratives on the Euro 2004 victory in the Greek and foreign press and media, along with the slogans used by football fans after each victory, voicing the ‘superiority’ of Greekness.   Keywords: Greekness, national identity, media, gender, hegemonic masculinity, sport, Euro 2004, Rehhagel, economic crisis, historical memory,  the closest other      

The Black-Litterman (BL) model is a particularly essential analytical tool for effective portfolio management in financial services sector since it enables investment analysts to integrate investor views into market equilibrium returns. In this research, we define and study the continuous-time BL portfolio optimization (CTBLPO) problem as a time-varying quadratic programming (TVQP) problem. The investor’s views in the CTBLPO problem are regarded as a forecasting problem, and they are generated by a novel neural network (NN) model. More precisely, employing a novel multi-function activated by a weights-and-structure-determination for time-series (MAWTS) algorithm, a 3-layer feed-forward NN model, called MAWTSNN, is proposed for handling time-series modeling and forecasting problems. Then, using real-world datasets, the CTBLPO problem is approached by two different TVQP NN solvers. These solvers are the zeroing NN (ZNN) and the linear-variational-inequality primal–dual NN (LVI-PDNN). The experiment findings illustrate and compare the performances of the ZNN and LVI-PDNN in three various portfolio configurations, as well as indicating that the MAWTSNN is an excellent alternative to the traditional approaches. To promote and contend the outcomes of this research, we created two MATLAB repositories for the interested user, that are publicly accessible on GitHub.

BACKGROUND/OBJECTIVE: Aetiology and significance of exercise-induced troponin release remains a contentious issue. We investigated the effect of a 28 km mountain run on cardiac troponin I (cTnI), in relation to training, performance, nutritional, biochemical and echocardiography variables, in a group of 25 recreational male master athletes. MATERIAL AND METHODS: A comprehensive list of variables related with nutrition, training, performance and echocardiography, was collected pre- and post-race. Twenty-four months later, outcomes regarding cardiovascular events were obtained. RESULTS: Serum cTnI values were increased after the race, with mean values rising from 7.2 +/- 2.2 (before) to 80.0 +/- 33.2 ng/L (post race), (p < 0.001) and 23/25(92%) exceeding Upper Reference limit (50 ng/L). Echocardiography did not reveal significant alterations, or correlations with cTnI values. The percentage difference in hs-cTnI concentrations pre- and post-race correlated positively with age, race-induced changes of selected muscle damage indices, resistance training volume and negatively with endurance capacity and training volume (r: -0.727 to 0.725, p < 0.05). All athletes reported no cardiovascular event during the 24-month period post-race. CONCLUSION: cTnI elevation induced by a 28 km mountain running race was not correlated with echocardiographic, nutritional parameters and was less pronounced in athletes with larger endurance training history, in contrast with resistance training and age

Various forms of the algebraic Riccati equation (ARE) have been widely used to investigate the stability of nonlinear systems in the control field. In this paper, the time-varying ARE (TV-ARE) and linear time-varying (LTV) systems stabilization problems are investigated by employing the zeroing neural networks (ZNNs). In order to solve the TV-ARE problem, two models are developed, the ZNNTV-ARE model which follows the principles of the original ZNN method, and the FTZNNTV-ARE model which follows the finite-time ZNN (FTZNN) dynamical evolution. In addition, two hybrid ZNN models are proposed for the LTV systems stabilization, which combines the ZNNTV-ARE and FTZNNTV-ARE design rules. Note that instead of the infinite exponential convergence specific to the ZNNTV-ARE design, the structure of the proposed FTZNNTV-ARE dynamic is based on a new evolution formula which is able to converge to a theoretical solution in finite time. Furthermore, we are only interested in real symmetric solutions of TV-ARE, so the ZNNTV-ARE and FTZNNTV-ARE models are designed to produce such solutions. Numerical findings, one of which includes an application to LTV systems stabilization, confirm the effectiveness of the introduced dynamical evolutions.

In this paper, we present a fraud detection framework for publicly traded firms using an optimization approach integrated with a meta-heuristic algorithm known as Beetle Antennae Search (BAS). Existing techniques include human resources, like financial experts and audit teams, to determine the ambiguities or financial frauds in the companies based on financial and non-financial ratios. It is a laborious task, time-consuming, and prone to errors. We designed an optimization problem to minimize the loss function based on a non-linear decision function combined with the maximization of recall (Sensitivity and Specificity). We solved the optimization problem iteratively using the BAS. It is a nature-inspired algorithm and mimics the beetle’s food-searching nature. It includes a single searching particle to find an optimal solution to the optimization problem in n-dimensional space. We used a benchmark dataset collected from SEC’s Accounting and Auditing Enforcement Releases (AAERs) for the simulation. It includes 28 raw financial variables and the data collected between 1991–2008. For the comparison, we evaluated the performance of BAS with the recently proposed approach using RUSBoost. We also compared it with some additional algorithms, i.e., Logit and SVM-FK. The results showed that BAS is comparable with these algorithms and outperformed them in time consumption.

As the interest in natural, sustainable ecosystems arises in many fields, wild plant diversity is reconsidered. The present study is based on extant literature evidence from the journey of John Sibthorp (Professor of Botany, Oxford University) to Peloponnese (Greece) in pre-industrial time. In the year 1795, Peloponnese was a botanically unknown region, very dangerous for travellers and under civil unrest, in conjuncture with a pre-rebellion period. Our study reveals approximately200 wild plant taxa that were collected from Peloponnese localities in 1795, transported to Oxford University (UK), and quoted in the magnificent edition Flora Graeca Sibthorpiana of the 19th century. Moreover, these plants currently constitute a living collection in Peloponnese, confirmed according to updated data on the vascular Flora of Greece. The presented lists constitute a source of informationfor plant biologists, linking the past to the present, shedding light on the study of adaptive traits of wild Mediterranean plants and revealing the temporal dimension of natural history. Nowadays, increasing and thorough understanding of the considered plants’ functionality to abiotic and biotic environmental stimuli provides a new framework of sustainability and management options.

In order to create a cultural landscape, the number of different types of ecomuseums around the world, covering many sites, has recently increased. Their establishment aims at the protection of natural and cultural resources. The north area of Syros Island offers significant opportunities for the development of a museum model that promotes the sustainable development of the local community. The aim of this study is to investigate the feasibility of developing a museum model that promotes the sustainable development of the local community in Apano Meria, Syros Island, which is a representative site with natural, geological, and archaeological heritage. For this purpose, the engagement and participation of the local inhabitants was evaluated through various activities, the basic principles of which are based on the concepts of New Museology and, more specifically, those of ecomuseums. Qualitative research was carried out through on-site observations, including discussions, participant observation, documentation, and in-depth interviews with local people. This research revealed that, so far, the conservation of the Apano Meria landscape is mainly due to the action of local people, who have repeatedly been called upon to show strong resistance to external factors that threatened to alter it. In their long-term effort to preserve and protect the area, but also to develop it in terms of sustainable development, the idea of its possible future inclusion in the UNESCO Global Network of Geoparks was proposed.

Moscow managed to "diplomatically" contain the Baku-Yerevan-Stepanakert explosion since Russia reemerged in a dominant and decisive way as a peacekeeping military and economic actor in the Armenia-Azerbaijan dipole. In fact, Russia stopped more bloodshed, might drive it away from its "regular" ally, Turkey, and cut all ties with Azerbaijan handing it over to the West. Therefore, this explains Moscow's initiative to propose solutions to the Pashinyan government inclusive of a peaceful return of Azeri refugees from areas of Sushi, before its eventual handover to the Azeris, under the guarantee of Russia's own military presence in order to "ensure cohabitation between Armenian residents and Azeri repatriates". However, these proposals, which would have meant Artsakh's "losing" of a single province (Sushi), were not accepted by Pashinyan, precisely because of his effort to avoid all Russian presence in the region. After all, his Government's members also pushed in this direction. His mistake, however, proved to be huge and the price was paid by the unfortunate Armenians of Artsakh.

Greece, like the rest of the Mediterranean countries, faces wildland fires every year. Besides their short-term socioeconomic impacts, ecological destruction, and loss of human lives, forest fires also increase the burnt areas’ risk of flash flood phenomena, as the vegetation, which acted in a protective way against runoff and soil erosion, is massively removed. Among the most severe wildland fire events in Greece were those of summer 2021, which were synchronous to the very severe heat waves that hit the broader area of the Balkan Peninsula. More than 3600 km2 of land was burnt and a significant amount of natural vegetation removed. Three of the burnt areas are examined in this work, namely, Attica, Northern Euboea, and the Peloponnese, in order to assess their risk of future flash flood events. The burnt areas were mapped, and their geological and geomorphological features studied. Flash flood hazard assessment was accomplished through a Boolean logic-based model applied through Geographic Information Systems (GIS) software, which allowed the prioritization of the requirement for protection by identifying which locations were most prone to flooding. The largest part of our study areas is characterized by geomorphological and geological conditions that facilitate flash flood events. According to our findings, in almost all study areas, the regions downstream of the burnt areas present high to very high flash flood hazard, due to their geomorphological and geological features (slope, drainage density, and hydrolithology). The only areas that were found to be less prone to flood events were Vilia and Varimpompi (Attica), due to their gentler slope inclinations and overall geomorphological characteristics. It is known that vegetation cover acts protectively against flash floods. However, in this case, large areas were severely burnt and vegetation is absent, resulting in the appearance of flash floods. Moreover, imminent flooding events are expected to be even more intense in the areas downstream of the burnt regions, possibly bearing even worse impacts on the local population, infrastructure, etc.

Geoscience courses, such as geology and geomorphology, require not only classroom lessons and laboratory exercises, but field trips as well. However, the COVID-19 restrictions did not allow the execution of most planned field trips, and an alternative needed to be developed. The use of virtual field trips is one such alternative. Through this research, we evaluate the usefulness of virtual field trips as tools for preparatory activities before an actual field trip takes place in the same area, and their contribution in providing a better understanding of geomorphological processes and landscape evolution. We performed a virtual navigation on the island of Naxos, Cyclades (Aegean Sea, Greece) for a series of virtual field trips, which took place during webinars in the framework of Erasmus+ CIVIS. The virtual field trip was also presented to the third-year students of the Faculty of Geology and Geoenvironment, National and Kapodistrian University of Athens, in the framework of the obligatory course of Geomorphology. Upon completion, all participating students were asked to fill in a questionnaire in order to evaluate the contribution of virtual field trips to their education regarding geomorphology and state their opinion as to whether they can supplement and/or substitute actual field trips. According to the results, virtual field trips can aid, but not substitute, the actual field trip. Most students mentioned that they would attend another virtual field trip in the future, both as an alternative to classroom lessons and as a means of preparation for an actual field trip, but not in order replace the actual one. Virtual field trips can significantly support the realization of actual ones, by introducing the necessary tectonic, geological and geomorphological background of a particular study area and offering more time for practical activities or field methodologies during the actual field trip.

Synthesis and study of RotA, an inhibitor of glycogen phosphorylase (GP), which when bound at the active site of GP, produces a strong fluorescence signal, allowing utilization of RotA as a probe that brings GP “to light” in the cellular milieu.

Nutrient transporters have been shown to translocate to the plasma membrane (PM) of the filamentous fungus an unconventional trafficking route that bypasses the Golgi. This finding strongly suggests the existence of distinct COPII vesicle subpopulations, one following Golgi-dependent conventional secretion and the other directed towards the PM. Here, we address whether Golgi-bypass concerns cargoes other than nutrient transporters and whether Golgi-bypass is related to cargo structure, size, abundance, physiological function, or polar vs. non-polar distribution in the PM. To address these questions, we followed the dynamic subcellular localization of two selected membrane cargoes differing in several of the aforementioned aspects. These are the proton-pump ATPase PmaA and the PalI pH signaling component. Our results show that neosynthesized PmaA and PalI are translocated to the PM Golgi-bypass, similar to nutrient transporters. In addition, we showed that the COPII-dependent exit of PmaA from the ER requires the alternative COPII coat subunit LstA, rather than Sec24, whereas PalI requires the ER cargo adaptor Erv14. These findings strengthen the evidence of distinct cargo-specific COPII subpopulations and extend the concept of Golgi-independent biogenesis to essential transmembrane proteins, other than nutrient transporters. Overall, our findings point to the idea that Golgi-bypass might not constitute a fungal-specific peculiarity, but rather a novel major and cargo-specific sorting route in eukaryotic cells that has been largely ignored.

Adopting an innovative and theoretical approach, Greek Tragedy and the Digital is an original study of the encounter between Greek tragedy and digital media in contemporary performance. It challenges Greek tragedy conventions through the contemporary arsenal of sound masks, avatars, live code poetry, new media art and digital cognitive experimentations. These technological innovations in performances of Greek tragedy shed new light on contemporary transformations and adaptations of classical myths, while raising emerging questions about how augmented reality works within interactive and immersive environments.Drawing on cutting-edge productions and theoretical debates on performance and the digital, this collection considers issues including performativity, liveness, immersion, intermediality, aesthetics, technological fragmentation, conventions of the chorus, theatre as hypermedia and reception theory in relation to Greek tragedy.Case studies include Kzryztof Warlikowski, Jan Fabre, Romeo Castellucci, Katie Mitchell, Georges Lavaudant, The Wooster Group, Labex Arts-H2H, Akram Khan, Urland & Crew, Medea Electronique, Robert Wilson, Klaus Obermaier, Guy Cassiers, Luca di Fusco, Ivo Van Hove, Avra Sidiropoulou and Jay Scheib. This is an incisive, interdisciplinary study that serves as a practice model for conceptualizing the ways in which Greek tragedy encounters digital culture in contemporary performance.

The dynamics of plasmas produced by low current X-pinch devices are explored. This comprehensive computational study is the first step in the preparation of an experimental campaign aiming to understand the formation of plasma jets in table-top pulsed power X-pinch devices. Two state-of-the-art magneto-hydro-dynamic codes, GORGON and PLUTO, are used to simulate the evolution of the plasma and describe its key dynamic features. GORGON and PLUTO are built on different approximation schemes and the simulation results obtained are discussed and analyzed in relation to the physics adopted by each code. Both codes manage to accurately handle the numerical demands of the X-pinch plasma evolution and provide precise details on the mechanisms of the plasma expansion, the jet-formation, and the pinch generation. Furthermore, the influence of electrical resistivity, radiation transport and optically thin losses on the dynamic behaviour of the simulated X-pinch produced plasma is studied in PLUTO. Our findings highlight the capabilities of the GORGON and PLUTO codes in simulating the wide range of plasma conditions found in X-pinch experiments, enabling a direct comparison to the scheduled experiments.

Blazar flares have been suggested as ideal candidates for enhanced neutrino production. While the neutrino signal of γ-ray flares has been widely discussed, the neutrino yield of X-ray flares has received less attention. Here, we compute the predicted neutrino signal from X-ray flares detected in 66 blazars observed more than 50 times with the X-ray Telescope (XRT) on board the Neil Gehrels Swift Observatory. We consider a scenario where X-ray flares are powered by synchrotron radiation of relativistic protons, and neutrinos are produced through photomeson interactions between protons with their own synchrotron X-ray photons. Using the 1 keV X-ray light curves for flare identification, the 0.5-10 keV fluence of each flare as a proxy for the all-flavour neutrino fluence, and the IceCube point-source effective area for different detector configurations, we calculate the number of muon and antimuon neutrinos above 100 TeV expected for IceCube from each flaring source. The bulk of the neutrino events from the sample originates from flares with durations ~1-10 d. Accounting for the X-ray flare duty cycle of the sources in the sample, which ranges between ~2 and 24 per cent, we compute an average yearly neutrino rate for each source. The median of the distribution (in logarithm) is ~0.03 yr-1, with Mkn 421 having the highest predicted rate 1.2 ± 0.3 yr-1, followed by 3C 273 (0.33 ± 0.03 yr-1) and PG 1553+113 (0.25 ± 0.02 yr-1). Next-generation neutrino detectors together with regular X-ray monitoring of blazars could constrain the duty cycle of hadronic X-ray flares.

The hyperpower family of iterative methods with arbitrary convergence order is one of the most used methods for estimating matrix inverses and generalized inverses, whereas the zeroing neural network (ZNN) is a type of neural dynamics developed to solve time-varying problems in science and engineering. Since the discretization of ZNN dynamics leads to the Newton iterative method for solving the matrix inversion and generalized inversion, this study proposes and investigates a family of ZNN dynamical models known as higher-order ZNN (HOZNN) models, which are defined on the basis of correlation with hyperpower iterations of arbitrary order. Because the HOZNN dynamical system requires error function powers, it is only applicable to square error functions. In this paper, we extend the original HOZNN dynamic flows to arbitrary time-dependent real matrices, both square and rectangular, and sign-bi-power activation is used to investigate the finite-time convergence of arbitrary order HOZNN dynamics. The proposed models are theoretically and numerically tested under three activation functions, and an application in solving the angle-of-arrival (AoA) localization problem demonstrates the effectiveness of the proposed design.

In order to design a geoeducation program in the context of the possibilities given to the Experimental Schools of Greece of Lower Secondary Education, teachers identified the need for diagnostically assess students’ understanding of basic concepts of the geoenvironment and particularly the concepts of geodiversity, geoheritage, geoethics and geotourism. In addition, there was a need to apply the educational technique of creating cognitive conflicts in order to promote the scientific perceptions of these concepts. Thus, research questions were identified which led the research to assess the current latent state of students’ perceptions regarding the thematic areas of the concepts and to identify concepts whose perceptions can be used in the educational process in order to achieve effective cognitive conflicts in order to promote scientific perceptions of them. The students briefly answered a four-question questionnaire, wherein each question examined their perceptions regarding the four concepts of geoenvironment: geodiversity, geoheritage, geoethics and geotourism. All 45 students of the geoeducation program that took part in the survey were aged between 12 and 15 years old. The qualitative research strategy approach was selected and specifically the hybrid technique of semiotics content analysis in combination with thematic analysis. This technique was selected due to the need to identify, code, categorize and count both obvious and latent meanings in the students’ written answers; these meanings were related to the four concepts under examination. The results of the research show that the current latent state of students’ perceptions regarding the thematic fields of the four concepts of the geoenvironment can be considered as particularly confused since the majority of students did not understand the concepts as they are employed in the international literature. The research also highlighted concepts that can be used by teachers in their efforts to develop students’ clear or even scientifically acceptable perceptions for the concepts of geodiversity, geoheritage, geoethics and geotourism in the thematic field of the geoenvironment.

The origin of Petaelectronvolt (PeV) astrophysical neutrinos is fundamental to our understanding of the high-energy Universe. Apart from the technical challenges of operating detectors deep below ice, oceans, and lakes, the phenomenological challenges are even greater than those of gravitational waves; the sources are unknown, hard to predict, and we lack clear signatures. Neutrino astronomy therefore represents the greatest challenge faced by the astronomy and physics communities thus far. The possible neutrino sources range from accretion disks and tidal disruption events, to relativistic jets and galaxy clusters with blazar TXS 0506+056 the most compelling association thus far. Since that association, immense effort has been put into proving or disproving that jets are indeed neutrino emitters, but to no avail. By generating simulated neutrino counterpart samples, we explore the potential of detecting a significant correlation of neutrinos with jets from active galactic nuclei. We find that, given the existing challenges, even our best experiments could not have produced a > 3σ result. Larger programs over the next few years will be able to detect a significant correlation only if the brightest radio sources, rather than all jetted active galactic nuclei, are neutrino emitters. We discuss the necessary strategies required to steer future efforts into successful experiments.

We provide necessary and sufficient conditions for the existence of idempotents of arbitrarily large norms in the Fourier algebra A(G) and the Fourier-Stieltjes algebra B(G) of a locally compact group G. We prove that the existence of idempotents of arbitrarily large norm in B(G) implies the existence of homomorphisms of arbitrarily large norm from A(H) into B(G) for every locally compact group H. A partial converse is also obtained: the existence of homomorphisms of arbitrarily large norm from A(H) into B(G) for some amenable locally compact group H implies the existence of idempotents of arbitrarily large norm in B(G).

Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a congenital condition characterizing females with absence of the uterus and part of the vagina. Several genetic defects have been correlated with the presence of MRKH; however, the exact etiology is still unknown due to the complexity of the genetic pathways implicated during the embryogenetic development of the Müllerian ducts. A systematic review (SR) of the literature was conducted to investigate the genetic causes associated with MRKH syndrome and Congenital Uterine Anomalies (CUAs). This study aimed to identify the most affected chromosomal areas and genes along with their associated clinical features in order to aid clinicians in distinguishing and identifying the possible genetic cause in each patient offering better genetic counseling. We identified 76 studies describing multiple genetic defects potentially contributing to the pathogenetic mechanism of MRKH syndrome. The most reported chromosomal regions and the possible genes implicated were: 1q21.1 (RBM8A gene), 1p31-1p35 (WNT4 gene), 7p15.3 (HOXA gene), 16p11 (TBX6 gene), 17q12 (LHX1 and HNF1B genes), 22q11.21, and Xp22. Although the etiology of MRKH syndrome is complex, associated clinical features can aid in the identification of a specific genetic defect.

This study presents experimental evidence of field emission in MEMS capacitive switches. Devices with dielectric layers of silicon nitride of different thicknesses between 50 and 200 nm were investigated by current-voltage (I-V) measurements. These measurements were performed at room temperature and under a controlled atmosphere pressure of 3 × 10−2 mbar at bias levels below breakdown and corresponding electric fields encountered in MEMS capacitive switches during pull-in (1-2 × 106 V/cm). Field emission although was not always clearly observed, it occurred in all devices and clearly manifested at electric fields larger than 106 V/cm.

AIMS: To investigate potential laboratory and imaging biomarkers as treatment response predictors to intravitreal anti-vascular endothelial growth factor (anti-VEGF) agents in patients with retinal vein occlusion (RVO). METHODS: Participants in this prospective study were 53 patients with treatment naive macular edema secondary to RVO, treated with intravitreal anti-VEGF agents and followed-up for 12 months. At baseline, all participants underwent best-corrected visual acuity measurement, dilated fundoscopy, optical coherence tomography and fluorescein angiography (FFA), while full blood count and biochemical analysis of various parameters was also performed. At month 12, treatment response was examined and classified as "favorable" or "non-response". Potential associations between laboratory/imaging biomarkers and treatment response were assessed. RESULTS: Univariate analysis showed that "favorable" response at month 12 after initiation of anti-VEGF treatment was correlated with baseline central subfield thickness (CST) < 464 mum (p < 0.001), absence of subretinal fluid (p = 0.004), absence of hyperreflective foci (HF) (p = 0.004), intact ellipsoid zone (EZ) and external limiting membrane (ELM) (p < 0.001 and p = 0.001, respectively), absence of epiretinal membrane (ERM) (p = 0.020) and absence of macular ischemia on FFA (p < 0.001), while increased monocytes-to-lymphocytes ratio was also associated with "favorable" treatment response (p = 0.010). All other laboratory parameters did not reach statistical significance. However, at the multivariate analysis, EZ and ELM status, HF, macular ischemia and monocytes-to-lymphocytes ratio were found to be independent predictors of treatment response. CONCLUSIONS: Intact EZ and ELM, absence of HF, absence of macular ischemia and increased monocytes-to-lymphocytes ratio at baseline can predict "favorable" treatment response in patients with treatment naive macular edema secondary to RVO

On September 27, 2021, an Mw=6.0 earthquake struck the central part of Crete Island (southern Greece) and in particular the Heraklion Region. This event was preceded by an extended foreshock sequence started on early July 2021 and it was followed by an Mw=5.3 aftershock on the following day. Taking into account the spatial distribution of foreshocks and aftershocks and the focal mechanism of mainshock as well as the active faults of the earthquake-affected area, it is evident that the seismic activity is strongly related to the NNE-SSW striking W-dipping faults of the Kasteli fault zone located along the eastern margin of the Neogene to Quaternary Heraklion Basin. The latter has been filled with Miocene to Holocene post-alpine deposits. A field reconnaissance conducted by the authors in the earthquake-affected area shortly after the mainshock revealed that the earthquake-triggered effects comprised mainly rockfalls and slides, as well as ground cracks within or close to landslide zones. These effects were located within the hanging-wall of the KFZ. The affected sites are mainly composed of Miocene deposits and they are characterized by pre-existing instability conditions and high susceptibility to landslides. Far field effects were also observed south of the earthquake-affected area and in particular in the southern coastal part of Heraklion Region. In regards to the spatial distribution of the earthquake-induced building damage, the vast majority was caused in villages and towns founded on Miocene and Holocene deposits of the hanging-wall. Damage was not reported in settlements located in the footwall, which is composed of alpine formations. The dominant building types of the earthquake-affected area comprise: (i) buildings with load-bearing masonry walls made of stones and bricks with clay or lime mortar, mainly constructed without any anti-seismic provisions and (ii) buildings with reinforced-concrete frame and infill walls constructed according to the applicable seismic codes. The former suffered the most severe structural damage including partial or total collapse in many villages founded on post-alpine deposits of the hanging-wall of KFZ. The latter responded satisfactory during the mainshock and were less affected with only non-structural damage including cracking, detachment of infill walls from the surrounding reinforced concrete frame, peeling of concrete and short-column failures. From the abovementioned, it is concluded that the impact of the 2021 Arkalochori earthquake was limited to the hanging-wall of the causative fault zone and in particular to residential areas founded on post-alpine deposits and to slopes highly susceptible to failure within the Heraklion Basin.

Imperatorin, a naturally derived furanocoumarin, exerts promising neuropharmacological properties. Therefore, it might be applicable in the treatment of brain diseases such as depression. In the present project, we aimed to investigate the sex-dependent effects of imperatorin (1, 5, and 10 mg/kg) on behavior and neurochemistry associated with antidepressant effects. The depressive-like behaviors of male and female Swiss mice were investigated in a forced swim test (FST). Subsequently, High-Performance Liquid Chromatography (HPLC) was used to evaluate the level of serotonin, its metabolite, 5-HIAA, and noradrenaline, in mouse brains. The study revealed that only males responded to imperatorin (1 and 5 mg/kg) treatment and caused an antidepressant effect, such as with respect to depressive-like behaviors, lowering immobility time and increasing immobility latency. The HPLC analysis demonstrated that serotonin levels in the prefrontal cortex of females decreased with the middle dose of imperatorin (5 mg/kg), while in the male prefrontal cortex, the lower dose (1 mg/kg) boosted serotonin levels. There were no evident changes observed with respect to noradrenaline and serotonin metabolite levels in the male hippocampus. To conclude, we propose that imperatorin has antidepressant potential, seemingly only in males, influencing brain serotonin level, but the direct mechanism of action requires further investigation.

This work reports on light scattering by a homogeneous dielectric sphere with a periodically time-varying radius. The off-shell inelastic scattering T matrix, which describes the dynamically changing particle, is evaluated using the Floquet method, and some remarkable phenomena, emerging in the strong- and weak-coupling regimes, are discussed. In particular, the limits of validity of the approximate quasistatic solution are established through comparison with the results of fully dynamic calculations, and the scattering in the strong-coupling regime is analyzed in terms of the general behavior of parametrically driven oscillators. Additionally, the influence of damping of the sphere vibrations on the optical spectra is also investigated.

Mediterranean tectonically-active coastal areas are a highly-dynamic environment balancing internal tectonic dynamics with external geomorphic processes, as well as manmade influences. Especially in touristic areas characterized by high built-up pressure and land value, where these dynamics are even more concentrated, the evolution of coastal environments needs careful and high-resolution study to identify localized risk and the processes they derive from.Recently, new advanced remote sensing techniques such as Unmanned Aerial Systems (UAS)- and Terrestrial Laser Scanners (TLS)-aided monitoring have improved our capabilities in understanding the natural processes and the geomorphic risks (i.e. mass movement phenomena).An integrated study comprising Unmanned Aerial Vehicles (UAV) and Light Detection And Ranging (LIDAR) sensors was conducted in coastal areas of the southern Ionian Islands (Western Greece) aiming to the mitigation of earthquake-triggered landslide risk and to responsible coastal development. Located at the northwesternmost part of the Hellenic Arc, this area is characterized by high seismicity and has been affected by destructive earthquakes mainly due to the Cephalonia Transform Fault Zone (CTFZ), which constitutes one of the most seismic active structures in the Eastern Mediterranean region. One of the most common environmental effect triggered by these earthquakes are landslides distributed along fault scarps in developed and highly visited coastal areas. Furthermore, this area is highly susceptible to hydrometeorological hazards inducing intense geomorphic processes, including Medicanes among others.These technologies allow a highly-detailed view of landslide processes, providing insights on the structures and factors controlling and triggering failures along coastal scarps as well as highlighting susceptible zones and high-risk areas with accuracy and mitigating adverse effects with precision and clarity. Overall, by providing a better understanding of the risks the approach used allows a more sustainable development of these coastal segments enhanced by risk mitigation.The study was conducted in the framework of the project “Telemachus - Innovative Operational Seismic Risk Management System of the Ionian Islands”, co-financed by Greece and the European Union (European Regional Development Fund) in Priority Axis “Environmental Protection and Sustainable Development” of the Operational Programme “Ionian Islands 2014–2020”.

Plasma membrane (PM) transporters of the major facilitator superfamily (MFS) are essential for cell metabolism, growth and response to stress or drugs. In Saccharomyces cerevisiae, Jen1 is a monocarboxylate/H+ symporter that provides a model to dissect the molecular details underlying cellular expression, transport mechanism and turnover of MFS transporters. Here, we present evidence revealing novel roles of the cytosolic N- and C-termini of Jen1 in its biogenesis, PM stability and transport activity, using functional analyses of Jen1 truncations and chimeric constructs with UapA, an endocytosis-insensitive transporter of Aspergillus nidulans. Our results show that both N- and C-termini are critical for Jen1 trafficking to the PM, transport activity and endocytosis. Importantly, we provide evidence that Jen1 N- and C-termini undergo transport-dependent dynamic intramolecular interactions, which affect the transport activity and turnover of Jen1. Our results support an emerging concept where the cytoplasmic termini of PM transporters control transporter cell surface stability and function through flexible intramolecular interactions with each other. These findings might be extended to other MFS members to understand conserved and evolving mechanisms underlying transporter structure-function relationships. This article has an associated First Person interview with the first authors of the paper.

Biodesulfurization is a process that selectively removes sulfur from dibenzothiophene and its derivatives. Several natural biocatalysts harboring the highly conserved desulfurization operon dszABC, which is significantly repressed by methionine, cysteine, and inorganic sulfate, have been isolated. However, the available information on the metabolic regulation of gene expression is still limited. In this study, scarless knockouts of the reverse transsulfuration pathway enzyme genes cbs and metB were constructed in the desulfurizing strain Rhodococcus sp. strain IGTS8. We provide sequence analyses and report the enzymes' involvement in the sulfate- and methionine-dependent repression of biodesulfurization activity. Sulfate addition in the bacterial culture did not repress the desulfurization activity of the Deltacbs strain, whereas deletion of metB promoted a significant biodesulfurization activity for sulfate-based growth and an even higher desulfurization activity for methionine-grown cells. In contrast, growth on cysteine completely repressed the desulfurization activity of all strains. Transcript level comparison uncovered a positive effect of cbs and metB gene deletions on dsz gene expression in the presence of sulfate and methionine, but not cysteine, offering insights into a critical role of cystathionine beta-synthase (CbetaS) and MetB in desulfurization activity regulation. IMPORTANCE Precise genome editing of the model biocatalyst Rhodococcus qingshengii IGTS8 was performed for the first time, more than 3 decades after its initial discovery. We thus gained insight into the regulation of dsz gene expression and biocatalyst activity, depending on the presence of two reverse transsulfuration enzymes, CbetaS and MetB. Moreover, we observed an enhancement of biodesulfurization capability in the presence of otherwise repressive sulfur sources, such as sulfate and l-methionine. The interconnection of cellular sulfur assimilation strategies was revealed and validated.

Protein phosphorylation is a major regulatory mechanism of cellular signalling. The c-JUN proto-oncoprotein is phosphorylated at four residues within its transactivation domain (TAD) by the JNK family kinases, but the functional significance of c-JUN multisite phosphorylation has remained elusive. Here we show that c-JUN phosphorylation by JNK exhibits defined temporal kinetics, with serine63 and serine73 being phosphorylated more rapidly than threonine91 and threonine93. We identify the positioning of the phosphorylation sites relative to the kinase docking motif, and their primary sequence, as the main factors controlling phosphorylation kinetics. Functional analysis reveals three c-JUN phosphorylation states: unphosphorylated c-JUN recruits the MBD3 repressor, serine63/73 doubly-phosphorylated c-JUN binds to the TCF4 co-activator, whereas the fully phosphorylated form disfavours TCF4 binding attenuating JNK signalling. Thus, c-JUN phosphorylation encodes multiple functional states that drive a complex signalling response from a single JNK input.

Cephalonia, located in the middle of the central Ionian Islands, has been affected by destructive earthquakes during both the instrumental and the historical period. Despite the fact that it is widely studied from several scientific viewpoints, limited research has been conducted so far regarding the earthquake-triggered landslides (ETL) and the related susceptibility. In the context of the present study, an inventory with 67 ETL from 11 earthquakes that occurred from 1636 to 2014 is presented. Given this record, the study further examines the ETL susceptibility exploiting 10 landslide causal factors in the frame of a GIS-based Analytic Hierarchy Process (AHP). Four factors (i.e., slope, PGA, tectonic structures and lithology) were associated in a higher degree to the locations where ETL occurred on the island. Based on the comparison of the ETL inventory and the landslide susceptibility index (LSI) map, the distribution of ETL in Cephalonia is not random, as their majority (82%) were generated within high to critically high susceptible zones. This fact, along with the AUC values of 80.3%, reveals a fair-to-good accuracy of the landslide susceptibility assessment and indicate that the contribution of the studied variables to the generation of ETL was effectively determined

The aim of the research is the awakening, participation and alertness of educators and students of Primary Education schools in Greece when it comes to rapid onset Natural Disasters pre-emption. The aim is the alertness of educators, as well as students of school units, so that they are able to face rapid onset natural disasters with prudence and composure, both during them, by putting themselves in the minimum possible danger, and after their finish, by taking part in the rehabilitation of “damages” of any kind. At an early stage, through the distribution of two questionnaires, one for educators and one for students, we invited the participants to answer questions relevant to their status and knowledge, when it comes to rapid onset natural disasters and their safe living in their school environment. In total, the participants exceeded two thousand (2,000) persons. One thousand twenty seven (1,027) educators, serving the Primary Education, and nine hundred eighty four (984) random students from all over the country, answered the digital questionnaires created through the application ArcGIS Survey123 (part of Geospatial Cloud by Esri), which is an integrated solution to the creation, distribution and analysis of survey data. From the statistical analysis of their answers, their beliefs regarding the subject examined arose and the proposed means of action is profiled, so that persons participating on the educational procedure can achieve their meaningful training, in order for them to feel safer and more aware, imparting their knowledge regarding rapid onset natural disasters. Their considering training programs about natural disasters necessary is clear, as the majority of them accept that any natural disaster is liable to occur while they are at school. The conducted research showed that the knowledge of educators and students regarding their responsibilities, as well as the necessary items and services which are essential during the occurrence of the natural phenomenon, as well as after its finish, seem to be inadequate.

The aim of the research is the awakening, participation and alertness of educators and students of Primary Education schools in Greece when it comes to rapid onset Natural Disasters pre-emption. The aim is the alertness of educators, as well as students of school units, so that they are able to face rapid onset natural disasters with prudence and composure, both during them, by putting themselves in the minimum possible danger, and after their finish, by taking part in the rehabilitation of “damages” of any kind. At an early stage, through the distribution of two questionnaires, one for educators and one for students, we invited the participants to answer questions relevant to their status and knowledge, when it comes to rapid onset natural disasters and their safe living in their school environment. In total, the participants exceeded two thousand (2,000) persons. One thousand twenty seven (1,027) educators, serving the Primary Education, and nine hundred eighty four (984) random students from all over the country, answered the digital questionnaires created through the application ArcGIS Survey123 (part of Geospatial Cloud by Esri), which is an integrated solution to the creation, distribution and analysis of survey data. From the statistical analysis of their answers, their beliefs regarding the subject examined arose and the proposed means of action is profiled, so that persons participating on the educational procedure can achieve their meaningful training, in order for them to feel safer and more aware, imparting their knowledge regarding rapid onset natural disasters. Their considering training programs about natural disasters necessary is clear, as the majority of them accept that any natural disaster is liable to occur while they are at school. The conducted research showed that the knowledge of educators and students regarding their responsibilities, as well as the necessary items and services which are essential during the occurrence of the natural phenomenon, as well as after its finish, seem to be inadequate.

The aim of the research is the awakening, participation and alertness of educators and students of Primary Education schools in Greece when it comes to rapid onset Natural Disasters pre-emption. The aim is the alertness of educators, as well as students of school units, so that they are able to face rapid onset natural disasters with prudence and composure, both during them, by putting themselves in the minimum possible danger, and after their finish, by taking part in the rehabilitation of “damages” of any kind. At an early stage, through the distribution of two questionnaires, one for educators and one for students, we invited the participants to answer questions relevant to their status and knowledge, when it comes to rapid onset natural disasters and their safe living in their school environment. In total, the participants exceeded two thousand (2,000) persons. One thousand twenty seven (1,027) educators, serving the Primary Education, and nine hundred eighty four (984) random students from all over the country, answered the digital questionnaires created through the application ArcGIS Survey123 (part of Geospatial Cloud by Esri), which is an integrated solution to the creation, distribution and analysis of survey data. From the statistical analysis of their answers, their beliefs regarding the subject examined arose and the proposed means of action is profiled, so that persons participating on the educational procedure can achieve their meaningful training, in order for them to feel safer and more aware, imparting their knowledge regarding rapid onset natural disasters. Their considering training programs about natural disasters necessary is clear, as the majority of them accept that any natural disaster is liable to occur while they are at school. The conducted research showed that the knowledge of educators and students regarding their responsibilities, as well as the necessary items and services which are essential during the occurrence of the natural phenomenon, as well as after its finish, seem to be inadequate.

The current study aims to clarify the structural regime of the deltaic valley of Pineios river (Thessaly, Greece). The structural control of a deltaic area is usually a crucial parameter for its Palaio-geographical evolution and the latter needs to be clear for the contemporary conservation of such a sensitive ecotope environmentally. The investigation of the concealed subsurface tectonic structures was accomplished through the combined interpretation of gravity measurements, VES and TEM soundings. The standard gravity data reduction has been carried out and the residual anomaly was isolated with the contribution of the Fourier filters. The Euler deconvolution has been applied, providing the corresponding depth solutions between 159.8 and 1716.6 m. In the context of the qualitative interpretation, we produced several structural maps (THDR, VDR, Tilt and Theta) in order to enhance the edges of density sources that may reflect fault zones. Severe indications for the delineation of fault zones of the area were provided by these maps. Moreover, 3D density models of the area have been constructed illustrating the subsurface density distribution, up to depths of 3370 m. A main zone of lower densities in the central part of the delta has been revealed, surrounded by three zones of higher densities. Afterwards, the densities of the majority of the existing geological formations were determined with laboratory measurements from geological specimens. Therefore, three geophysical-geological profiles have been constructed, based not only on the gravity modelling but also on the geological interpretation of the geoelectrical layered models from the VES and TEM measurements. In conclusion, concealed and unknown tectonic structures of the Pineios deltaic valley have been identified beneath the surface.

The current study aims to clarify the structural regime of the deltaic valley of Pineios river (Thessaly, Greece). The structural control of a deltaic area is usually a crucial parameter for its Palaio-geographical evolution and the latter needs to be clear for the contemporary conservation of such a sensitive ecotope environmentally. The investigation of the concealed subsurface tectonic structures was accomplished through the combined interpretation of gravity measurements, VES and TEM soundings. The standard gravity data reduction has been carried out and the residual anomaly was isolated with the contribution of the Fourier filters. The Euler deconvolution has been applied, providing the corresponding depth solutions between 159.8 and 1716.6 m. In the context of the qualitative interpretation, we produced several structural maps (THDR, VDR, Tilt and Theta) in order to enhance the edges of density sources that may reflect fault zones. Severe indications for the delineation of fault zones of the area were provided by these maps. Moreover, 3D density models of the area have been constructed illustrating the subsurface density distribution, up to depths of 3370 m. A main zone of lower densities in the central part of the delta has been revealed, surrounded by three zones of higher densities. Afterwards, the densities of the majority of the existing geological formations were determined with laboratory measurements from geological specimens. Therefore, three geophysical-geological profiles have been constructed, based not only on the gravity modelling but also on the geological interpretation of the geoelectrical layered models from the VES and TEM measurements. In conclusion, concealed and unknown tectonic structures of the Pineios deltaic valley have been identified beneath the surface.

We investigate an earthquake sequence involving an Mw = 4.6 mainshock on 2 December 2020, followed by a seismic swarm in July–October 2021 near Thiva, Central Greece, to identify the activated structures and understand its triggering mechanisms. For this purpose, we employ double-difference relocation to construct a high-resolution earthquake catalogue and examine in detail the distribution of hypocenters and the spatiotemporal evolution of the sequence. Furthermore, we apply instrumental and imaging geodesy to map the local deformation and identify long-term trends or anomalies that could have contributed to stress loading. The 2021 seismic swarm was hosted on a system of conjugate normal faults, including the eastward extension of the Yliki fault, with the main activated structures trending WNW–ESE and dipping south. No pre- or coseismic deformation could be associated with the 2021 swarm, while Coulomb stress transfer due to the Mw = 4.6 mainshock of December 2020 was found to be insufficient to trigger its nucleation. However, the evolution of the swarm is related to stress triggering by its major events and facilitated by pore-fluid pressure diffusion. The re-evaluated seismic history of the area reveals its potential to generate destructive Mw = 6.0 earthquakes; therefore, the continued monitoring of its microseismicity is considered important.

We investigate an earthquake sequence involving an Mw = 4.6 mainshock on 2 December 2020, followed by a seismic swarm in July–October 2021 near Thiva, Central Greece, to identify the activated structures and understand its triggering mechanisms. For this purpose, we employ double-difference relocation to construct a high-resolution earthquake catalogue and examine in detail the distribution of hypocenters and the spatiotemporal evolution of the sequence. Furthermore, we apply instrumental and imaging geodesy to map the local deformation and identify long-term trends or anomalies that could have contributed to stress loading. The 2021 seismic swarm was hosted on a system of conjugate normal faults, including the eastward extension of the Yliki fault, with the main activated structures trending WNW–ESE and dipping south. No pre- or coseismic deformation could be associated with the 2021 swarm, while Coulomb stress transfer due to the Mw = 4.6 mainshock of December 2020 was found to be insufficient to trigger its nucleation. However, the evolution of the swarm is related to stress triggering by its major events and facilitated by pore-fluid pressure diffusion. The re-evaluated seismic history of the area reveals its potential to generate destructive Mw = 6.0 earthquakes; therefore, the continued monitoring of its microseismicity is considered important.

Τhis study aims to investigate to what extent the drainage systems of the northern part of Evia Island, in Central Greece, reflect the contemporary tectonic regime of the area. The effects of tectonic activity have been detected and described by performing a landscape morphological analysis of the drainage systems, followed by a field survey for validating the results. The Relative Declivity Extension (RDE) index, which is based on the Stream Length (SL) gradient index, was calculated along the channels of 189 drainage basins of the study area, using the Knickpoint Finder tool integrated into ArcGIS desktop. The Hack RDE index is defined by the ratio of the RDEs index (which refers to a stretch) and the RDEt index (which refers to the total length of a river) was applied, and its calculation identifies the knickpoints based on anomaly values detection along the longitudinal profiles of the rivers. Furthermore, knickpoint analysis was carried out along the channels of the drainage networks of the northern part of the Evia Island and the corresponding anomaly maps were designed. A total of 2,486 knickpoints were identified and the greatest anomalies (139 points), named first-order anomalies (RDE>10), seem to correspond to a recently shaped or rejuvenated landscape, indicative of intense neotectonic activity. In some cases, the spatial distribution of knickpoints delineates a NW-SE trending yielding the structural control of the study area. The comparison of the results with the lithological map of the area showed that about 30% of the knickpoints are lithologically controlled. The identification of zones of neotectonic activity and consequently the existence of active faults is highly correlated with the distribution of knickpoints and their core density, the drainage density, the drainage asymmetries, and other morphometric indices such as the hypsometric integral, along with the earthquake epicentres, and the morpho-lineament density. The overall analysis showed a positive correlation of the concentration of the derived knickpoints with both active structures and tectonic activity rates. The results were consistent with field observations, which were mainly focused on waterfall landforms. Our study proves that the landscape evolution of the northern part of the Evia Island is considerably affected by the recent activity of normal fault zones, whereas the drainage systems react to the changes of base-level providing insights on active tectonics.

Resumen: Emilia Pardo Bazán (España, 1851-1921) y Federico Gamboa (México, 1864-1939) son dos escritores representativos del Naturalismo. En la novela La Tribuna (1883), Emilia Pardo Bazán, a través de su protagonista Amparo, ofrece un testimonio invalorable tanto de las condiciones laborales en España de su época, como de los acontecimientos históricos que condujeron a la proclamación de la I República, en 1873. Por otro lado, Federico Gamboa en la novela Santa (1903) mediante la protagonista, que huye a la prostitución de modo patético, presenta la situación histórico-social del Porfiriato, antes del estallido de la Revolución Mexicana de 1910. El objetivo de este estudio es definir la posición de la mujer en contextos históricos concretos condicionados por la época y el entorno político y social. Palabras clave: naturalismo, novela, mujer, historia, sociedad.

High-resolution pollen analysis of a sediment core recovered from Paliouras lagoon (Greece) allowed us to reconstruct the environmental dynamics of the Halkidiki peninsula during the last 4000 years. Palynological results have been interpreted and compared with detailed historical data, showing distinct phases of human-landscape interactions from the Bronze Age until recent times. Pollen spectra revealed an environment characterized by Mediterranean vegetation, mixed deciduous forest, and pine stands from the Late Bronze Age until the 11th century CE. The first signs of human impact were attested during the Archaic period with the cultivation of Olea, Castanea, and Vitis in the inland of the study area. An intensive land management was highlighted by arboriculture and cereal cultivation (Secale and Hordeum group) in Roman times. Late Antique-Early Medieval times coincided with less human pressure due to warfare-related crises, leading to the expansion of the forest and the abandonment of fields colonized by Amaranthaceae. A massive increase in pastoral activities, suggested by the high percentages of Cichorieae during the Ottoman period, is possibly linked to the significant demographic growth of the nearby city of Thessaloniki in the 16th century CE.

Technical advancements have widened the limits of remote sensing and Terrestrial Laser Scanning technology in studying underground cavities. Furthermore, the use of Unmanned Aerial Systems has proven to be a significant advantage in the study of caves, as under certain circumstances during the data processing, it is plausible to combine TLS and UAS data for generating a complete 3D model, representing surface and subsurface simultaneously. The use of state-of-the-art laser scanning equipment either terrestrial or handheld accompanied by total station measurements on a series of ground control points, has resulted in the scanning and detailed mapping the entire Melissani and Drogarati caves, in Cephalonia Island, in Greece, including hidden cavities. This study attempted not only to delineate a new methodology for compiling a highly detailed cave map, but also to identify structural discontinuities and faults for further investigation of the influence of rock failures in causing rock falls and further damage in the caves. Both show caves attract many visitors and since they are located at an area of very high seismicity, where large earthquakes occur very frequently, the risk is rather high. The methodology is based on the synergy of equipment in different working levels, since the cave environment is by far one of the most difficult cases to survey, led to hazard identification in high detail and accuracy throughout the cavity. The fieldwork includes the generation of a unified point cloud for the underground cavity, generated by scanning at several bases inside the cave and by entering smaller cavities by holding the mobile scanner. The bundling of the partial point clouds is possible since the proposed methodology includes the establishment of a dense network of Ground Control Points, which are measured with Total Station equipment for gaining actual coordinates. After the merging of the partial scans were combined into a single point cloud, the methodology continues with further processing including filtering and noisy points removal. Moreover, the final product is combined with the point cloud that was generated after the photogrammetric processing and the methodology is completed with exporting the results in file formats that can be imported in several geotechnical or discontinuity recognition software for further interpretation. The results along with the produced 3D models could be utilized to determine areas susceptible to different failure types. The assessment of rock stability within a cave by combined innovative equipment, techniques, and research methods could be considered by the management authorities for the maintenance and/or re-design the tourist routes.

Combined with eustatic sea-level changes, uplifted Quaternary marine terraces provide insight into the tectonics of coastal areas. Cephalonia Island lies 35 km off the western coast of mainland Greece and 15 km northeast of the Hellenic subduction zone. Late Pleistocene eustatic sea-level oscillations and the long-term tectonic movements are imprinted on the landscape of the southern part of the island, in the form of seven uplifted marine terraces. In the present study we aim to identify and map in detail these terraces, applying Digital Elevation Model analysis, utilizing Geographic Information Systems techniques and extensive fieldwork. The GIS-based analysis combined with field geomorphological observations revealed a sequence of seven marine terraces at the southern part of the main island ranging in elevation between 4 m and 176 m asl. Microscope, petrological and microgeomorphological analyses on two caprock samples suggest strong marine influence during the deposition of the sediments covering the marine terraces. The age of the formation of the 32 m marine terrace was assigned to the MIS 3e, based on OSL dating of a caprock sample, and an average uplift rate of 1.4 ± 0.35 mm a−1 was calculated for the last 61 ± 5.5 ka. Assuming a uniform uplift rate for the Late Pleistocene allowed us to correlate the marine terrace with the sea-level highstands and constrain their ages.

In this study, we present the findings of a sediment core retrieved from Klisova lagoon, Western Greece, an area with a long record of documented human presence. The recovered deposits were subjected to sedimentological, XRF, and micropaleontological analyses. For the last 4700 cal BP, the freshwater influx, the progradation of the Evinos river delta and related geomorphological changes control the environmental conditions in the lagoon. Considering the centennial temporal resolution of our analyses, small offsets of c.a. 50?years due to lack of regional reservoir correction do not considerably impact the reported radiocarbon ages. Prior to 4000 cal BP, a relatively shallow water depth, significant terrestrial/freshwater input and increased weathering in the lagoon area are inferred. Elemental proxies and increased dinoflagellate cyst and foraminiferal abundances, which indicate marine conditions with prominent freshwater influxes, point to the gradual deepening of the lagoon up to 2000 cal BP. The marine and freshwater condition equilibrium sets at 1300 cal BP, with the lagoonal system reaching its present state. Maxima of anthropogenic pollen indicators during the Mycenaean (3200 cal BP), Hellenistic (2200 cal BP), and Late Byzantine (800 cal BP) periods suggest intervals of increased anthropogenic activities in the area.

The present paper examines lexicon organization and lexical uniqueness through a lexicalavailability task. Previous research has concentrated on exploring via word association testshow learners organize their L1 and L2 lexicons. Additionally, the closeness between the nativeand the L2 lexicons are also object of analysis in research. Lexical uniqueness has also beenused as a measure to determine “nativeness”. In the present study, we had two groups ofGreek B1 and C1 level learners of Spanish FL answer a lexical availability task and comparedtheir results with those of a group of native speakers. We found that proficiency level is crucialin the determination of lexical uniqueness and lexicon organization via lexical associationsobtained with a lexical availability task. Furthermore, our results revealed that thematic fieldis a relevant factor in speakers’ associative behaviour and lexicon organization. Results arediscussed in light of previous research findings and pedagogical implications are proposed.

Fear of Missing Out (FoMO) – people’s intense concerns that they might miss pleasant moments that their peers may enjoy—has been found to relate to a variety of undesired outcomes, including poor academic functioning. Yet, little is known about why some students may exhibit more FoMO than others. In this cross-sectional study with a sample of Turkish adolescents (N1 = 506; 50.8% males; Mage = 15.8 years; SD = 0.83), we examined to what extent intrinsic and extrinsic life goals for using social media predict FoMO over and above social anxiety. We found through path analyses that extrinsic goals of attaining popularity, garnering attention, and conveying a positive image of oneself to others related to FoMO which in turn related to lower grades by means of in-class distraction and out-of-class study interference. Taken together, the present results suggest that the goals that adolescents try to attain through social media use may explain why FoMO might be more prevalent in that age group.

BACKGROUND: Hepatocellular carcinoma (HCC) can be treated by local and regional methods of percutaneous interventional radiological techniques. Indications depend on tumor size, type and stage, as well as patient's condition, liver function and co-morbidities. According to international classification systems such as Barcelona Clinic Liver Cancer (BCLC) classification, very early, early or intermediate staged tumors can be treated either with ablative methods or with transarterial chemoembolization (TACE), depending on tumor characteristics. The combination of both allows for individualized forms of treatment with the ultimate goal of improving response and survival. In recent years, a lot of research has been carried out in combining locoregional approaches with immune therapy. Although recent developments in systemic treatment, especially immunotherapy, seem quite promising and have expanded possible combined treatment options, there is still not enough evidence in their favor. The aim of this review is to provide a comprehensive up-to-date overview of all these techniques, explaining indications, contraindications, technical problems, outcomes, results and complications. Moreover, combinations of percutaneous treatment with each other or with immunotherapy and future options will be discussed. Use of all those methods as down-staging or bridging solutions until surgery or transplantation are taken into consideration will also be reviewed. CONCLUSION: Local and regional therapies remain a mainstay of curative and palliative treatment of patients with HCC. Currently, evidence on potential combination of the local and regional treatment options with each other as well as with other treatment modalities is growing and has the potential to further individualize HCC therapy. To identify the most suitable treatment option out of these new various options, a repeated interdisciplinary discussion of each case by the tumor board is of utmost importance.

Au lendemain de la Seconde Guerre mondiale, dans un contexte de décolonisation progressive, Louise Weiss, reporter de renommée, écrivaine et femme politique, s’engage activement dans la défense de l’empire colonial français déjà assailli impitoyablement. Chargée de maintes missions politiques et culturelles, elle se lance dans un long voyage (1946-1968) à destination de tous les points chauds du globe : Japon, Indochine, Chine, Syrie, Liban, Égypte, Sénégal, Éthiopie, Djibouti, Madagascar, Tibet et Cachemire, entre autres. Tentative d’intervention sur le cours de la politique internationale autant que recherche sur « l’aspiration générale de l’humanité », le voyage « weissien », pratique et écritures, est à la fois acte cognitif et politique. Sous ce rapport, le récit viatique de la journaliste, vecteur de ses prises de positions politiques, sociales et idéologiques au regard des nouveaux enjeux géopolitiques et culturels qui émergent dans un monde en ébullition, revêt un caractère autant instructif que propagandiste. Sur un autre plan, il dévoile l’inquiétude d’une Européenne devant la déchéance morale de la civilisation occidentale.

To improve the manoeuvrability of differential drive mobile robots around a straight path on a horizontal plane, an I/O decoupling control scheme is proposed through a proportional controller that uses real time measurements of the kinetic variables of the mobile robot and measurements of the orientation of the robot, received through a wireless network providing communication delays. The present control scheme is based on the linear approximant of the robot model. The I/O decoupling design requirement is proven to be always satisfied and the controller is proven to be a common controller for various values of the robot parameters The stability and asymptotic command following of the closed loop system is studied. The resemblance of the performance of the closed loop system, using the delayed controller, to the respective response of the closed loop system for zero delay, is accomplished through a metaheuristic algorithm. The efficiency of the derived controller when applied to the nonlinear model of the mobile robot is illustrated through simulations.

This paper aims to present research on measuring competences for democratic culture. It describes the development of a multiple-item scale that measures competences in teaching democratic citizenship and human rights through religious education. A principal component analysis based on the 135 items of the Council of Europe’s Reference framework of competences for democratic culture was carried out in two phases, in order to construct and refine the scale. The result was a 52-item scale divided into six components. This was tested for its reliability, factor structure and validity; firstly on a sample of 123, and secondly on a sample of 403 secondary RE teachers (2018-19). The research scrutinises the concept of democratic competences as being the ability to mobilise and deploy relevant values, attitudes, skills, knowledge and/or understanding. It concludes that these competences are more complex structures than has been assumed.

The interannual variability of the Mediterranean overturning circulation is investigated using a high-resolution (1/36°) ocean model. As the overturning circulation regulates the replenishment and ventilation of the deep layers, we study the spatiotemporal scales of the maximum value of the overturning streamfunction over three main sub-basins of dense water formation (Aegean Sea, Adriatic, and the northwestern Mediterranean). The variability of the zonal overturning is also discussed. The spectrum analysis shows that the overturning variability has its largest signal on annual timescales in all sub-basins, explained by perpetual winter formation. On shorter frequencies (decadal) there are marked differences observed, due to regional processes of the overturning cells, led by buoyancy flux long-term variability in each sub-basin. The decomposition of the total overturning circulation into barotropic, geostrophic shear, and Ekman components revealed weakening and strengthening for the Aegean and Adriatic Sea total overturning, respectively, with opposite trends for the barotropic and geostrophic shear components. The simultaneous contribution of the Ekman and geostrophic component to the total overturning differentiates the variability of zonal overturning circulation from the local meridional overturning circulation of the three sub-basins. The cross spectra between the maximum overturning value and the buoyancy fluxes also revealed that the system keeps the “memory” of this forcing and shows annual variability.

              The neural stem cell niche is a key regulator participating in the maintenance, regeneration, and repair of the brain. Within the niche neural stem cells (NSC) generate new neurons throughout life, which is important for tissue homeostasis and brain function. NSCs are regulated by intrinsic and extrinsic factors with cellular metabolism being lately recognized as one of the most important ones, with evidence suggesting that it may serve as a common signal integrator to ensure mammalian brain homeostasis. The aim of this review is to summarize recent insights into how metabolism affects NSC fate decisions in adult neural stem cell niches, with occasional referencing of embryonic neural stem cells when it is deemed necessary. Specifically, we will highlight the implication of mitochondria as crucial regulators of NSC fate decisions and the relationship between metabolism and ependymal cells. The link between primary cilia dysfunction in the region of hypothalamus and metabolic diseases will be examined as well. Lastly, the involvement of metabolic pathways in ependymal cell ciliogenesis and physiology regulation will be discussed. Keywords: cell mechanics; ciliopathies; ependymal; metabolism; neural stem cell niche; neural stem cells; subventricular zone (SVZ).     

PI controllers are favorable for implementation in most industrial computer controller platforms as well as integrated circuit platforms. In the present paper a multivariable Proportional plus Integral (PI) controller is designed for the regulation of ethanol concentration in a continuous fermenter, being a reactor with several industrial and biomedical applications. Based upon the nonlinear model of the fermentation process, a linear approximant of the process is analytically derived. The range of accuracy of the linear approximant is determined using a mixed norm criterion. Based upon the linear approximant and a metaheuristic algorithm, a multivariable PI controller is designed in order to satisfy stability for the closed loop system, asymptotic command following for the ethanol concentration and model following of the respective closed loop linear approximant system. Performance of the proposed control scheme when applied to the original nonlinear model is satisfactory, even for large external commands.

OBJECTIVE: The objective of this research was to evaluate how menstrual tracking applications can promote gynaecological health. MATERIALS AND METHODS: We performed a systematic review in Medline and Scopus, for papers evaluating menstrual tracking mobile applications. We excluded review articles and those not written in English. RESULTS: We identified 14 articles measuring the outcome resulting from the use of a single Fertility Tracking Application (FTA). Eight studies evaluated 2 different applications used as a contraception method. One study assessed a fecundity enhancing application. Five studies referred to applications, used to treat or monitor various gynaecologic issues. All studies reported efficacy for their intended use or a high satisfaction rate. DISCUSSION: There is a plethora of FTAs, however a minority of them are appraised by medical experts. Several safety and privacy concerns have been expressed regarding their use and these issues should be addressed in the future. All studies identified in our search demonstrated that FTAs can facilitate users in terms of contraception, fertility, and menstrual awareness. CONCLUSION: Menstrual tracking applications can serve as a valuable health tool, nevertheless, their content should be more vigorously evaluated.

This study provides a high-resolution reconstruction of the vegetation of the Argive Plain (Peloponnese, Greece) covering 5000 years from the Early Bronze Age onwards. The well dated pollen record from ancient Lake Lerna has been interpreted in the light of archaeological and historical sources, climatic data from the same core and other regional proxies. Our results demonstrate a significant degree of human impact on the environments of the Argive Plain throughout the study period. During the Early Bronze Age evidence of a thermophilous vegetation is seen in the pollen record, representing the mixed deciduous oak woodland of the Peloponnesian uplands. The plain was mainly used for the cultivation of cereals, whereas local fen conditions prevailed at the coring site. Towards the end of this period an increasing water table is recorded and the fen turns into a lake, despite more arid conditions. In the Late Bronze Age, the presence of important palatial centres modified the landscape resulting in decrease of mixed deciduous oak woodland and increase in open land, partly used for grazing. Possibly, the human management produced a permanent hydrological change at Lake Lerna. From the Archaic period onwards the increasing human pressure in association with local drier conditions caused landscape instability, as attested by a dramatic alluvial event recorded in the Pinus curve at the end of the Hellenistic Age. Wet conditions coincided with Roman times and favoured a forest regeneration pattern in the area, at the same time as we see the most intensive olive cultivation in the pollen record. The establishment of an economic landscape primarily based on pastures is recorded in the Byzantine period and continues until modern times. Overgrazing and fires in combination with arid conditions likely caused degradation of the vegetation into garrigue, as seen in the area of the Argive Plain today.

BACKGROUND: Despite significant advances in multiple myeloma (MM) therapy, disease relapse and treatment resistance remain major obstacles in clinical management. Herein, we have studied the clinical utility of miRNAs in improving patients' risk-stratification and prognosis. METHODS: miRNA-seq was performed in CD138+ plasma cells of MM, smoldering multiple myeloma (sMM) and monoclonal gammopathy of undetermined significance (MGUS) patients. The screening MM cohort consisted of 138 patients. miRNA levels of CD138+ plasma cells were quantified by RT-qPCR following 3'-end RNA polyadenylation. Disease progression and patients' death were used as clinical end-point events. Internal validation was conducted by bootstrap analysis. Clinical net benefit on disease prognosis was assessed by decision curve analysis. Kruykov et al. 2016 served as validation cohort (n = 151). RESULTS: miRNA-seq highlighted miR-181a to be upregulated in MM vs. sMM/MGUS, and R-ISS III vs. I patients. Screening and validation cohorts confirmed the significantly higher risk for short-term progression and worse survival of the patients overexpressing miR-181a. Multivariate models integrating miR-181a with disease established markers led to superior risk-stratification and clinical benefit for MM prognosis. CONCLUSIONS: CD138+ overexpression of miR-181a was strongly correlated with inferior disease outcome and contributed to superior prediction of MM patients early progression, supporting personalised prognosis and treatment decisions.

Mitochondria are the main sites of energy production and a major source of metabolic stress. Not surprisingly, impairment of mitochondrial homeostasis is tightly associated with the development and progression of a broad spectrum of human pathologies, including neurodegenerative disorders. Mitophagy mediates the selective degradation of damaged organelles, thus promoting cellular viability and tissue integrity. Defective mitophagy triggers cellular senescence and prolonged neuroinflammation, leading eventually to cell death and brain homeostasis collapse. Here, we survey the intricate interplay between mitophagy and neuroinflammation, highlighting that mitophagy can be a focal point for therapeutic interventions to tackle neurodegeneration.

The problem of controlling the position of a magnetically levitated ball is studied through a PD state feedback linear controller and the simultaneous satisfaction of a set of individual miscellaneous design requirements including stability, command following, model following and appropriately bounded input. The requirements are defined over the linear approximant of the magnetic levitation system. Also, for the solution of the problem, a metaheuristic algorithm, based on the linear approximant of the magnetic levitation system, is proposed. The performance of the proposed control scheme, for the resulting nonlinear closed loop system, is illustrated through a series of computational experiments.

One of the brightest X-ray pulsars in the Small Magellanic Cloud is SMC X-2. During its most recent major outburst in 2015, this transient pulsar displayed significant changes in both its accretion state and magnetosphere, particularly when it entered the low-luminosity regime of subcritical accretion. Polestar is a pulse-profile modeling code that helps in delineating the geometry of the emission as the source evolves past outburst and toward lower-luminosity states. Applying Polestar to XMM-Newton and NuSTAR pulse profiles, we constrained the most likely inclination of the spin axis of the pulsar to be i = 87° ± 4°. As the X-ray luminosity declined, an increase in the pulsed fraction was detected from Swift observations, which suggests a transition from fan- to pencil-beam emission during the later stages of the outburst. Additionally, we also performed analysis of the OGLE IV light curves, which showed strong modulation in the optical profiles during the outburst.

Les modifieurs de degré (MD) ‘très’ et ‘beaucoup’ du français et ‘πολύ’ du grec présentent de différentes conditions de combinabilité avec les adjectifs. Nous soutenons l’hypothèse que la différence entre propriété temporaire et permanente détermine l’acceptabilité de ces MD avec des adjectifs. Il est proposé que ‘beaucoup’ se combine avec des adjectifs qui sont ambigus exprimant soit une propriété temporaire soit une propriété permanente. Plus précisément, ‘beaucoup’ assume le rôle du désambiguïseur qui sélectionne toujours la facette temporaire des adjectifs avec lesquels il se combine. Les MD ‘très’ et ‘πολύ’, quant à eux, ne sont pas sensibles à la différence entre propriété temporaire et permanente.   

Using the analytic finite deterministic automata models of the subsystems of an automated manufacturing system, in circular mode, the safety specifications of the system are formulated in the form of rules. The rules are translated to appropriate desired regular languages. The languages are realized in analytic forms of finite deterministic supervisor automata. The controllability of the languages, realized by the supervisors, and the nonblocking property of the resulting controlled automaton, are proven.

Multiple lines of evidence support an immunologic response along with inflammation to be implicated in the pathophysiology of primary rhegmatogenous retinal detachment (RRD) and the development of proliferative vitreoretinopathy (PVR). The purpose of this review is to provide an update on the signaling molecules in the vitreous and subretinal fluid (SRF) involved in these processes. A detailed literature search was performed in PubMed database until November 2021. We identified all papers referring to inflammatory and immunological mediators in the context of primary RRD and in cases complicated by PVR. We analyzed prospective and retrospective cohort studies and reference lists of the retrieved articles. A comprehensive investigation of immunological and inflammatory responses provides significant evidence for the implication of varying signaling molecules in the pathophysiology of RRD and the development of PVR. The reviewed series has revealed that disruption of the normal equilibrium during these processes may be present in the vitreous and SRF of these eyes. The precise role of cytokines, chemokines, and growth factors in the pathophysiology of these disorders remains to be clearly elucidated. Overall, immunological and inflammatory signaling molecules are widely implicated in both primary RRD and PVR. The reviewed literature indicates that precise knowledge concerning the pathological milieu sheds light on the underlying pathophysiology and potential therapeutic targets and highlights unmet needs to be addressed by future research

Neuronets trained by a weights-and-structure-determination (WASD) algorithm are known to resolve the shortcomings of traditional back-propagation neuronets such as slow training speed and local minimum. A multi-input multi-function activated WASD neuronet (MMA-WASDN) model is introduced in this paper, combined with a novel multi-function activated WASD (MA-WASD) algorithm, for handling binary classification problems. Using multiple power activation functions, the MA-WASD algorithm finds the optimal weights and structure of the MMA-WASDN and uses cross-validation to address bias and prevent being stuck in local optima during the training process. As a result, neuronets trained with the MA-WASD algorithm have higher precision and accuracy than neuronets trained with traditional WASD algorithms. Applications on firm fraud and loan approval classification validate our MMA-WASDN model in order to demonstrate its outstanding learning and predicting performance. Since these applications use real-world datasets that include strings and missing values, an algorithmic method for preparing data is also suggested to make them manageable from the MMA-WASDN. A comparison of the MMA-WASDN model to five other high-performing neuronet models is included, as well as a MATLAB package that is publicly available through GitHub to support and promote the findings of this research.

Introduction. Longitudinal volleyball training stimuli can cause an increase in muscle strength that is brought about by neurological and morphological adaptations, such as changes in muscle fibre composition percentage and cross-sectional area (CSA). Aim of Study. The aim of this study was to examine the biological adaptations of volleyball-players in terms of muscle fiber type composition, cross-sectional area, myonuclei and satellite cell pool in comparison to physically active controls. Material and Methods. Ten professional volleyball-players (VG) and five physically active-persons (CG) participated in this study. Muscle biopsies were obtained from the vastus-lateralis of the dominant leg. Results. Immunohistochemical analysis revealed that although MHC I and MHC IIC muscle fibre distribution was not different between the groups, MHC IIX and MHC IIAX were totally absent in VG and appeared only in the CG. The cross-sectional area revealed a slightly different pattern as both MHC I and IIA were larger for the volleyball players. In accordance, MHC II myonuclei number was moderately larger in the volleyball players, while the satellite cells and their ratio to number of fibres had a large and very large difference, respectively. Conclusions. In conclusion, our study reveals that volleyball training-induced hypertrophy for both type I and II muscle fibres in the vastus lateralis of volleyball players and resulted in a specific shift in muscle fibres containing MHC II isoforms. This hypertrophy of the muscle fibres is associated with an increase in the myonuclear number and satellite cells.

Lefkada and Corfu old towns are located in the western part of Greece, in the Ionian Sea. Their proximity to the Hellenic subduction zone (HSZ) is the reason for their intense seismicity. The main goal of this study was the estimation of the geotechnical characteristics of the subsurface, with the contribution of applied geophysical techniques. Therefore, seismic refraction tomography (SRT) and multichannel analysis of surface waves (MASW) were applied. A total of thirty-three (33) seismic and geoelectrical profiles were performed in both towns in order to evaluate the geotechnical characteristics of the subsurface formations. Additionally, subsurface resistivity distributions were investigated with the application of electrical resistivity tomography (ERT). Some important elastic moduli were calculated through the combination of estimated seismic wave velocities and laboratory density measurements. The horizontal distribution of seismic velocities and mechanical properties (σ, E, K, G) of Corfu town was illustrated in maps, for the depth of 5 m. The geophysical interpretation also revealed that Lefkada’s subsurface consists of only one compact geological formation, with little or no variation of its geophysical-geotechnical characteristics. Beyond that, the ground type classifications for the two towns were determined according to the European Committee for Standardization Eurocode 8, based on Vs30 values.

Lefkada and Corfu old towns are located in the western part of Greece, in the Ionian Sea. Their proximity to the Hellenic subduction zone (HSZ) is the reason for their intense seismicity. The main goal of this study was the estimation of the geotechnical characteristics of the subsurface, with the contribution of applied geophysical techniques. Therefore, seismic refraction tomography (SRT) and multichannel analysis of surface waves (MASW) were applied. A total of thirty-three (33) seismic and geoelectrical profiles were performed in both towns in order to evaluate the geotechnical characteristics of the subsurface formations. Additionally, subsurface resistivity distributions were investigated with the application of electrical resistivity tomography (ERT). Some important elastic moduli were calculated through the combination of estimated seismic wave velocities and laboratory density measurements. The horizontal distribution of seismic velocities and mechanical properties (σ, E, K, G) of Corfu town was illustrated in maps, for the depth of 5 m. The geophysical interpretation also revealed that Lefkada’s subsurface consists of only one compact geological formation, with little or no variation of its geophysical-geotechnical characteristics. Beyond that, the ground type classifications for the two towns were determined according to the European Committee for Standardization Eurocode 8, based on VS30 values.

The use of multiple-input multiple-output (MIMO) non-orthogonal multiple access (NOMA) based communication protocols is proposed and investigated for the uplink of wireless networks with buffered data-sources, which is the basis of the introduced medium access control (MAC)-layer protocol. To this end, the long-term average throughput is maximized by optimizing the set of users that transmit information at each time slot and their transmit power, the number of packets that are admitted in each user’s queue, and the transmission rates, assuming that the instantaneous channel state information is not available at the transmitters. Also, considering a receiver with multiple antennas, two detection techniques are used to mitigate the interference when two users are chosen to simultaneously transmit information in the same resource block, namely successive interference cancellation (SIC) and joint decoding (JD). More specifically, the outage probability for both considered techniques is derived in closed-from, which is a prerequisite for the derivation and the optimization of the throughput. The formulated multi-dimensional long-term stochastic optimization problem is solved by using the Lyapunov framework. Finally, simulation results verify the gains by using MIMO-NOMA as the basis of the next generation multiple access and illustrate the superiority of JD compared to SIC with respect to the number of the receiver’s antennas.

Abstract Ru-porphyrins act as convenient pedestals for the assembly of N-heterocyclic carbenes (NHCs) on solid surfaces. Upon deposition of a simple NHC ligand on a close packed Ru-porphyrin monolayer, an extraordinary phenomenon can be observed: Ru-porphyrin molecules are transferred from the silver surface to the next molecular layer. We have investigated the structural features and dynamics of this portering process and analysed the associated binding strengths and work function changes. A rearrangement of the molecular layer is induced by the NHC uptake: the NHC selective binding to the Ru causes the ejection of whole porphyrin molecules from the molecular layer on silver to the layer on top. This reorganisation can be reversed by thermally induced desorption of the NHC ligand. We anticipate that the understanding of such mass transport processes will have crucial implications for the functionalisation of surfaces with carbenes.

Background Provision of structure in classroom settings constitutes one of the pillars of conducive learning environments. However, little is known whether the particular elements of provided structure—namely, contingency, clear expectations, help and support, and monitoring—are equally important for student learning and motivation. Aims In this cross-sectional study, we aimed to investigate to what extent students’ autonomous motivation is linearly and curvilinearly related to their perceptions of their teachers’ contingency, clear expectations, help and support, and monitoring. Sample Participants were 12,036 Turkish adolescent students (age range: 15–19 years; 54.4% males) from 446 classes, nested into 24 public schools. Methods Cross-sectional, based on student ratings of their self-determined motivation and their teacher structure provision and autonomy support. Results Multilevel and ordinary least-squares polynomial regression analyses showed all the four perceived structure elements to predict autonomous motivation, with expectations and contingency (especially when coupled with monitoring) being even more important predictors than the other elements. Response surface analyses also showed strong positive relation between autonomous motivation and all the possible pairs of the four elements of perceived structure along the line of congruence, suggesting an additive effect when teachers are thought to be contingent and helpful and supportive (or monitor their students, or clearly communicate their expectations). Conclusions These findings imply the key role that teachers could play in enhancing their students’ autonomous motivation by providing all the elements of structure.

The non-convex tax-aware portfolio optimization problem is traditionally approximated as a convex problem, which compromises the quality of the solution and converges to a local-minima instead of global minima. In this paper, we proposed a non-deterministic meta-heuristic algorithm called Non-linear Activated Beetle Antennae Search (NABAS). NABAS explores the search space at the given gradient estimate measure until it is smaller than a threshold known as “Activation Threshold”, which increases its convergence rate and avoids local minima. To test the validity of NABAS, we formulated an optimization-based tax-aware portfolio problem. The objective is to maximize the profit and minimize the risk and tax liabilities and fulfill other constraints. We collected stock data of 20 companies from the NASDAQ stock market and performed a simulation using MATLAB. A comprehensive comparison is made with BAS, PSO, and GA algorithms. The results also showed that a better-optimized portfolio is achieved with a non-convex problem than a convex problem.

A time Floquet transfer-matrix method for the description of acoustic wave propagation through dynamic stratified structures, modulated by another, low-frequency, pump acoustic wave, is reported. The method is applied to a specific example of a GaAs/AlAs periodic superlattice, subject to a spatiotemporal modulation induced by an evanescent pump wave with frequency in the lowest acoustic band gap of the structure. By means of systematic numerical calculations, we provide compelling evidence for the occurrence of significant nonreciprocal transmission of an acoustic signal with frequency in a high-order acoustic band gap, through inelastic multiple-scattering processes. Our results indicate a promising route to design nonreciprocal acoustic devices.

The Kastrouli Late Bronze settlement in Phocis province, central Greece, has been proved to have been an important center in the periphery of the Mycenaean palaces. It was reused at least partially and was cultivated until the 20th century. The presence of a flat area off the Kastrouli hill and the seasonal flooding nowadays led to the present investigation, questioning the formation of an ancient lake or marsh/swamp. A methodological approach was applied combining the digital elevation model (DEM) and GIS of the wider and confined area, examining slopes between 0 and 5 degrees (0 and 8.75%), with electrical resistivity tomography (ERT) traverses of around 300 and 500 m, reaching a depth of 100 m. The ERT data were rapidly collected on profiles and provided a cross-sectional (2D) plot. It was found that, in the area, there is a basin with a length of 100 m and a depth of around 40–50 m. The sedimentation process over the millennia has filled the basin, with the upper 5–6 m surface layers of the area having a low resistivity. The presence of two natural sinkholes with apparent engineered hydraulic works is noted to conform to drainage and produce a habitable environment, protecting the cultivated land and avoiding a swamp associated with health issues.

Field geological mapping is the initial step of preliminary research in mining. However, in the last decades, the rapid progress of remote sensing data processing and its use for reconnaissance of geological outcrops for the purpose of locating possible mining sites gained increasing attention due to the significant time and cost savings. In this study, a new methodology, focused on mapping ferronickel (Fe–Ni) laterite deposits by using Sentinel-2 satellite data, is introduced. It describes a novel spectral index (called laterite spectral index (LSI)) that enhances laterite surface outcrops. To the best of our knowledge, LSI is the first spectral index tailored for this task, concerning minerals that are simultaneously rich in Fe and Ni. The LSI was applied on a continuum removed image by taking advantage of the spectral features present in two specific spectral areas of 490–560 nm and 842–945 nm. The entire methodology was tested and validated on four different excavation sites in eastern Central Greece based on known drillholes. In all excavation sites, the proposed LSI compared favorably with other relative spectral indices proposed in the literature for the detection of Fe-bearing minerals or Fe-oxides.

OBJECTIVE: To assess the risk for obstetric complications in women with congenital uterine anomalies and the risk in each main class of uterine anomaly (U2 [septate], U3 [bicorporeal], U4 [hemi-uterus]), based on the 2013 classification by the ESHRE (European Society of Human Reproduction and Embryology) and the ESGE (European Society for Gynaecological Endoscopy). DATA SOURCES: MEDLINE, Scopus, and ClinicalTrials.gov were searched from inception until January 2021. The reference list of all included articles and previous systematic reviews were also screened to identify potential additional articles. METHODS OF STUDY SELECTION: Comparative and noncomparative studies that investigated the obstetric outcomes of women with any type of known congenital uterine anomaly were considered eligible for inclusion. Screening and eligibility assessment was performed independently by two reviewers. TABULATION, INTEGRATION, AND RESULTS: Forty-seven studies were included. The quality of included comparative studies was assessed using the Newcastle-Ottawa Quality Assessment Scale. Odds ratios (ORs), pooled proportions of each obstetric outcome, and 95{%} CIs were calculated in RevMan and Stata accordingly, using random effects models. Congenital uterine anomalies were associated with increased risk of preterm birth (OR 3.89, 95{%} CI 3.11-4.88); cervical insufficiency (OR 15.13, 95{%} CI 11.74-19.50); prelabor rupture of membranes (OR 2.48, 95{%} CI 1.38-4.48); fetal malpresentation (OR 11.11, 95{%} CI 5.74-21.49); fetal growth restriction (OR 3.75, 95{%} CI 1.88-7.46); placental abruption (OR 5.21, 95{%} CI 3.34-8.13); placenta previa (OR 4.00, 95{%} CI 1.87-8.56); placental retention (OR 1.71, 95{%} CI 1.16-2.52); and cesarean birth (OR 4.52, 95{%} CI 2.19-9.31); when compared with those without anomalies. Pooled estimated risks were 25{%} for preterm birth, 40{%} for fetal malpresentation, 64{%} for cesarean birth, 12{%} for prelabor rupture of membranes, 15{%} for fetal growth restriction, 4{%} for placental abruption, 5{%} for preeclampsia, 13{%} for cervical insufficiency, and 2{%} for placenta previa. Classes U2 (septate), U3 (bicorporeal), and U4 (hemi-uterus) were also associated independently with preterm birth, fetal malpresentation, cesarean birth, and placental abruption. CONCLUSION: Congenital uterine anomalies are associated with obstetric complications across all examined ESHRE and ESGE classifications. SYSTEMATIC REVIEW REGISTRATION: PROSPERO, CRD42021244487.

Η Ευρωπαϊκή Ένωση (Ε.Ε.) θα μπορούσε να θεωρηθεί ως μία ευρύτερη γεωγραφική ενότητα μέσα στην οποία πραγματοποιούνται οικονομικές και κοινωνικές διεργασίες και στην οποία ασκούνται δημόσιες εθνικές ή ευρωπαϊκές πολιτικές. Είναι ιστορικό γεγονός ότι ο ευρωπαϊκός χώρος δεν αποτελεί μια ομοιογενή γεωγραφική ενότητα, αλλά παρουσιάζει μεγάλες ανισότητες που κληρονομήθηκαν από το παρελθόν. Το ερώτημα που τίθεται είναι, αν η διαδικασία της οικονομικής ολοκλήρωσης της Ε.Ε. -που άρχισε το 1958 μεταξύ των έξι ιδρυτικών χωρών και συνεχίζεται με αλλεπάλληλες διευρύνσεις μέχρι σήμερα- άμβλυνε τις ανισότητες, τις διατήρησε ή τις διεύρυνε. Στο συλλογικό αυτόν τόμο, επιχειρείται μία αποτίμηση των σημερινών ανισοτήτων μεταξύ των χωρών-μελών της Ε.Ε. και αξιολογούνται οι πολιτικές που ασκήθηκαν όλα αυτά τα χρόνια με στόχο την οικονομική και κοινωνική συνοχή, όπως έχει επανειλημμένως διακηρυχτεί στις συνθήκες της Ε.Ε. Στα επιμέρους κεφάλαια του βιβλίου, ειδικοί επιστήμονες, ερευνητές και καθηγητές από διάφορα πανεπιστήμια της χώρας μας και του εξωτερικού επιχειρούν να ανιχνεύσουν κατά πόσο οι πολιτικές που ασκήθηκαν είχαν το επιθυμητό αποτέλεσμα.

The Black Death (1347–1352 ce) is the most renowned pandemic in human history, believed by many to have killed half of Europe’s population. However, despite advances in ancient DNA research that conclusively identified the pandemic’s causative agent (bacterium Yersinia pestis), our knowledge of the Black Death remains limited, based primarily on qualitative remarks in medieval written sources available for some areas of Western Europe. Here, we remedy this situation by applying a pioneering new approach, ‘big data palaeoecology’, which, starting from palynological data, evaluates the scale of the Black Death’s mortality on a regional scale across Europe. We collected pollen data on landscape change from 261 radiocarbon-dated coring sites (lakes and wetlands) located across 19 modern-day European countries. We used two independent methods of analysis to evaluate whether the changes we see in the landscape at the time of the Black Death agree with the hypothesis that a large portion of the population, upwards of half, died within a few years in the 21 historical regions we studied. While we can confirm that the Black Death had a devastating impact in some regions, we found that it had negligible or no impact in others. These inter-regional differences in the Black Death’s mortality across Europe demonstrate the significance of cultural, ecological, economic, societal and climatic factors that mediated the dissemination and impact of the disease. The complex interplay of these factors, along with the historical ecology of plague, should be a focus of future research on historical pandemics.

Beachrocks are well known as significant proxies for paleoenvironmental analysis as they indicate the coastal evolution. The combination of geomorphological and archaeological sea level indicators has a significant contribution to the coastal paleogeographic reconstruction. In this study, we studied a beachrock from the Diolkos area (West Corinth canal, Greece) and remnants of Diolkos slipway to reconstruct the coastal evolution before Diolkos construction until today. We conducted detailed mapping of Diolkos beachrock using DGPS-GNSS, as well as mineralogical analysis and OSL dating of beachrock samples. The results showed that a beachrock slab was preserved before the construction of Diolkos below it, followed by its submergence by a co-seismic event after Diolkos abandonment during 146 B.C. Consequently, a new beachrock was developed on top of the submerged Diolkos around 120 ± 14 A.D. The RSL was stable until 1596 ± 57 A.D. when the beachrock developed even closer to the present-day coastline. After 1596 A.D., it was uplifted by 12 cm until it reached today’s condition.

Cyprus has a long history of tsunami activity, as described in archaeological and geological records. Although the study area has experienced tsunamis in the past and constitutes an area threatened by this hazard both from the Cyprean arc and from the neighboring Hellenic arc, field research on tsunami evidence on the coastal zone of Cyprus still remains scarce. It is clear from the literature that large boulder accumulations are an important feature along the coasts of Cyprus, testifying to extreme events. A detailed field survey revealed that at various locations cited in the literature as hosting geomorphological evidence of past tsunamis, no such evidence was identified. It is likely that the high touristic activity that has been occurring on the coasts of Cyprus during the last 20 years may have affected tsunami indicators such as boulder accumulations. Tsunamis are unpredictable and infrequent but potentially large-impact natural disasters. The latest strong tsunami that caused damage to the Cypriot coast was centuries ago, when the population and economic growth and development at the Cypriot shoreline did not exist. Today, the coastal zone hosts a higher population as well as increasing touristic activity, highlighting the need for better preparedness, awareness raising and for tsunami-related risk reduction. 

Paris in War: urban space mutations, through the prism of gender, during the Great War A city on the sidelines that records the echoes of, an often, distant conflict, Paris sees its physiognomy going through an alteration during the First World War. The mass exodoi of September 1914 and May 1918, the material disasters caused by the air raids of the Gothas, and the constant ‘hammerings’ of “Fat Bertha” from land between Mars and August 1918[1], the return of the wounded, all inscribe themselves on the urban landscape of the capital marking it in an unprecedented manner. But what changes the cityscape more drastically is the predominance of a feminization of the area which manifests itself with the geographical reorganization of the professional territory. This reconfiguration breaks up boundaries and partitions and renders the traditional space and gender dichotomies and polarizations obsolete. In turn, this restructuring imposes on figures of urban authority a new approach to public space, with a view to enforce new rules and frameworks on the multifaceted and ongoing evolutions. The current work, that stems from the issue of the ‘city in crisis’, proposes a discovery, through the Parisian example of 1914-1918, of the complicated nature-inherent with a gendered perspective-of a global vision that unites war, space and gender visibility. This is about demonstrating how the interaction of these two tools for the evaluation of mutations-the crisis and gender-functions as a cadre of transversal comprehension and interpretation of the urban dynamics and tensions that could potentially enrich and renew the history of cities. Therefore, the scope of the current project cannot be but multiple: to discover the innovation and the gendered professional geography (exercise of functions and professions that have traditionally and exclusively been reserved for males); to examine the interventional policies (recommendations, laws, ministerial circulars and work realized by feminist and charity associations) that have to do, in part, with regulating, organizing and finally normalizing this new spatial reality with multiple repercussions, and, on the other hand, to guarantee its temporary character that is associated with the anomaly of the moment; lastly, it interrogates a-pro-birth, hygienic and political-discourse according to which the construction of the peaceful city rests on the reestablishment of gender separated and dedicated places.

Refugee children have never been so numerous in Europe and especially in Greece, which is a major country of entry and hosting of refugees. These children are either accompanied or unaccompanied, and some have no relatives. According to the United Nations’ 1989 Convention of the Rights of the Child (CRC), “all CRC rights are to be granted to all persons under 18 years of age (Art. 1) without discrimination of any kind (Art. 2).” Refugee children, as all children, hold “the right to education” (Art.28), which aims to achieve “the preparation of the child for responsible life in a free society, in the spirit of understanding, peace, tolerance, equality of sexes, and friendship among all peoples, ethnic, national, and religious groups and persons of indigenous origin” (Art.29, 1d). Greek law, moreover, addresses that they all should have access to a full range of educational services, including school, university, and vocational training programs. Within this context, we argue for synergy between peace education, democratic citizenship, and social pedagogy and its potential to enable all children in schools, refugee children included, to be educated. This chapter focuses on a current initiative in 18 Northern Greek schools in which there are reception classes with the aim of the project being that 150 schools providing secondary education that offer reception classes would have taken part by the end of the school year 2020–2021. The program is titled “School for All—inclusion of refugee children in Greek schools” and is organized and run by the Wergeland Center and the Greek Ministry of Education and Religious Affairs that aim to support all school members with the ultimate goal of creating a democratic and inclusive school environment. The use of the Council of Europe’s ‘Whole school approach' and the Reference Framework of Competences for Democratic Culture (2018) are proposed to be used in practice. The first results that show reducing conflict are obvious, while it seems that a synergy between peace education, democratic citizenship, and social pedagogy can improve social cohesion within communities so as to increase resilience against conflict. Finally, the chapter reflects on the relationship between peacemaking and faith traditions, especially Greek Orthodox and Islamic traditions, as well as the value of inter-faith dialogue while aiming for inclusion.

Background: Although several studies that rely on self-determination theory have shown the positive interrelations among perceived need supportive learning environment, needs satisfaction, quality of motivation, and desired outcomes in the context of physical education, only few studies have tested so far the full sequence of relations within a single integrated model. Purpose: The main aim of this study was to test whether indeed needs satisfaction and in turn quality of motivation mediate the relations of need supportive learning environment to physical activity engagement and intentions. Method: Participants were 1120 Spanish students (49.9% males; Mage = 11.70 years; SD = 1.63; range = 10–17 years) from 30 classes out of 13 primary and secondary schools. Results: The multilevel path model showed a positive relation of perceived need-supportive teaching to physical activity engagement and intentions by means of needs satisfaction and autonomous motivation and a negative relation of perceived need-thwarting teaching to engagement and intentions by means of needs frustration and amotivation. Although controlled motivation was found to associate with need frustration and need-thwarting teaching it was not associated with engagement and intentions. Conclusion: the present findings suggest that the type of teaching style employed by the teachers is decisive to achieve positive consequences in physical education students. © 2020 Association for Physical Education.

All disc-accreting astrophysical objects produce powerful disc winds. In compact binaries containing neutron stars or black holes, accretion often takes place during violent outbursts. The main disc wind signatures during these eruptions are blue-shifted X-ray absorption lines, which are preferentially seen in disc-dominated `soft states'1,2. By contrast, optical wind-formed lines have recently been detected in `hard states', when a hot corona dominates the luminosity3. The relationship between these signatures is unknown, and no erupting system has as yet revealed wind-formed lines between the X-ray and optical bands, despite the many strong resonance transitions in this ultraviolet (UV) region4. Here we report that the transient neutron star binary Swift J1858.6-0814 exhibits wind-formed, blue-shifted absorption lines associated with C IV, N V and He II in time-resolved UV spectroscopy during a luminous hard state, which we interpret as a warm, moderately ionized outflow component in this state. Simultaneously observed optical lines also display transient blue-shifted absorption. Decomposing the UV data into constant and variable components, the blue-shifted absorption is associated with the former. This implies that the outflow is not associated with the luminous flares in the data. The joint presence of UV and optical wind features reveals a multi-phase and/or spatially stratified evaporative outflow from the outer disc5. This type of persistent mass loss across all accretion states has been predicted by radiation-hydrodynamic simulations6 and helps to explain the shorter-than-expected duration of outbursts7.

Philosophy, Arts, Therapies: PATh! A path toward a human protective life through Philosophy, Arts and Therapies! An innovative, interdisciplinary and humanistic approach for a life with meaning and freedom. Every paper opens a new path for self-awareness, meaningful communication with significant others, solidarity and creativity as the healthiest approach to human growth. Philosophy as well as the arts contains the potential for humans to exceed the limits of physical existence and transcend self so that man rises above mundane needs to reach elevation. It is when emotional and spiritual transcendence occurs through the innate healing qualities of philosophy and arts that man can become a man. Moreover, the fathers of psychoanalysis, humanistic and existential psychotherapies, i.e. Sigmund Freud, Carl Jung, Jacques Lacan, to mention a few, supported their theories and practice through philosophical currents and some of them, i.e. Carl Jung, Rollo May etc., derived profound inspiration from the arts.

Minimum-cost portfolio insurance (MCPI) is a well-known investment strategy that tries to limit the losses a portfolio may incur as stocks decrease in price without requiring the portfolio manager to sell those stocks. In this research, we define and study the time-varying MCPI problem as a time-varying linear programming problem. More precisely, using real-world datasets, three different error-correction neural networks are employed to address this financial TLPtime-varying linear programming problem in continuous-time. These neural network solvers are the zeroing NNneural network (ZNN), the linear-variational-inequality primal-dual NNneural network (LVI-PDNN), and the simplified LVI-PDNN (S-LVI-PDNN). The neural network solvers are tested using real-world data on portfolios of up to 20 stocks, and the results show that they are capable of solving the financial problem efficiently, in some cases more than five times faster than traditional methods, though their accuracy declines as the size of the portfolio increases. This demonstrates the speed and accuracy of neural network solvers, showing their superiority over traditional methods in moderate-size portfolios. To promote and contend the outcomes of this research, we created two MATLAB repositories for the interested user,research, we created two MATLAB repositories, for the interested user, that are publicly accessible on GitHub.

Blazars are the most extreme subclass of active galactic nuclei with relativistic jets emerging from a super-massive black hole and forming a small angle with respect to our line of sight. Blazars are also known to be related to flaring activity as they exhibit large flux variations over a wide range of frequency and on multiple timescales, ranging from a few minutes to several months. The detection of a high-energy neutrino from the flaring blazar TXS 0506+056 and the subsequent discovery of a neutrino excess from the same direction have naturally strengthened the hypothesis that blazars are cosmic neutrino sources. While neutrino production during gamma-ray flares has been widely discussed, the neutrino yield of X-ray flares has received less attention. Motivated by a theoretical scenario where high energy neutrinos are produced by energetic protons interacting with their own X-ray synchrotron radiation, we make neutrino predictions over a sample of a sample of X-ray blazars. This sample consists of all blazars observed with the X-ray Telescope (XRT) on board Swift more than 50 times from November 2004 to November 2020. The statistical identification of a flaring state is done using the Bayesian Block algorithm to the 1 keV XRT light curves of frequently observed blazars. We categorize flaring states into classes based on their variation from the time-average value of the data points. During each flaring state, we compute the expected muon plus anti-muon neutrino events as well as the total signal for each source using the point-source effective area of Icecube for different operational seasons. We find that the median of the total neutrino number (in logarithm) from flares with duration $<30$ d is $\mathcal{N}^{(\rm tot)}_{\nu_{\mu}+\bar{\nu}_{\mu}} \sim 0.02$.

This manuscript aims to establish various representations for the CMP inverse. Some expressions for the CMP inverse of appropriate upper block triangular matrix are developed. Successive matrix squaring algorithm and the method based on the Gauss–Jordan elimination are considered for calculating the CMP inverse. As an application, the solvability of several restricted systems of linear equations (RSoLE) is investigated in terms of the CMP inverse. Illustrative examples and examples on randomly generated large-scale matrices are presented.

Structure-from-motion photogrammetric processing and laser scanning technology have given us more tools to study environments such as caves with their complex and unique morphology. In this case study, we combine two innovative techniques to generate the complete 3D model of a show cave (Koutouki, Peania Greece) and calculate the rock thickness between the cave and the open surface. We used a Handheld Laser Scanner (HLS) for acquiring points with coordinate information covering the entire cave and an Unmanned Aerial System (UAS) for acquiring data covering the open-air surface above the cave. The absolute and exact placement of the point cloud within a geographic reference frame allow the three-dimensional measurements and detailed visualization of the subsurface structures. By processing of the multi-source data (UAS and HLS) we managed to make a quantitative analysis of the terrain. After a series of processing steps and analyses we managed to calculate with high accuracy several dimension such as the cavity vacuum, the speleothem volume, the elevation differences across the entire cave etc. The final product is a high-resolution information layer with measurements of the rock thickness between the roof of the underground karstic landform and the open-surface topography.

Quantum chemistry is a firmly established branch within theoretical chemistry. However, in the late 1920s and early 1930s when the first foundational papers and books appeared, mostly written by physicists as well as by chemists or chemical physicists, the disciplinary identity of the emerging field was a contentious issue: Was it physics or was it chemistry? This question was tied to the problem of reductionism and received different answers, which led to different ways of practicing quantum chemistry and eventually stabilized its identity as an in-between/ boundary discipline. During its subsequent development the question of disciplinary identity continued to be central, as quantum chemistry established connections to other disciplines and was deeply shaped by computing technology. In this chapter we discuss the historical development of quantum chemistry, integrating several strands, conceptual, institutional, methodological, and epistemological.

We present a toy model for radio emission in high-mass X-ray binaries (HMXBs) with strongly magnetized neutron stars (NSs) where a wind-collision region is formed by the NS outflow and the stellar wind of the massive companion. Radio emission is expected from the synchrotron radiation of shock-accelerated electrons and the free-free emission of the stellar wind. We found that the predicted relation between the GHz luminosity (LR) and the accretion X-ray luminosity (LX) can be written as $L_\mathrm{ R} \propto L_\mathrm{ X}^b$ for most parameters. No correlation with X-rays is expected (b = 0) when the thermal emission of the stellar wind dominates in radio. We typically find a steep correlation (b = 12/7) for sub-Eddington X-ray luminosities and a more shallow one [b = 2(p - 1)/7] for super-Eddington X-ray luminosities, where p is the power-law index of accelerated electrons. The maximum predicted radio luminosity is independent of the NS properties, while it depends on the stellar wind momentum, binary separation distance, and the minimum electron Lorentz factor. Using a Bayesian approach, we modelled the radio observations of Swift J0243.6+6124 that cover a wide range of mass accretion rates. Our results support a shock origin for the radio detections at sub-Eddington X-ray luminosities. However, no physically meaningful parameters could be found for the super-Eddington phase of the outburst, suggesting a different origin. Future observations with more sensitive instruments might reveal a large number of HMXBs with strongly magnetized NSs in radio, allowing the determination of the slope in the LR-LX relation, and putting the wind-collision scenario into test.

Reaction of the syn-bimetallic complex [Ti2(µ:η5,η5-Pn††)2] (1) (Pn†† = 1,4-(SiiPr3)2-C8H4) with 1,3-trans-butadiene in toluene results in the clean formation of the 1:1 adduct [Ti2(µ:η5,η5-Pn††)2(μ: η2,η2-s-trans-C4H6)] (2) featuring an essentially planar butadiene ligand. Complex (2) represents the first example of a bimetallic early transition metal complex where a coordinated butadiene adopts such a conformation. When (1) is reacted with propene an unexpected “tuck-over” alkene π-complex (3) is formed with co-current loss of propane. Complex (3) features a coordinated η2,η1 vinylic (H2C = CMe)-SiiPr2-Pn† moiety as a result of C–H activation of one of the isopropyl substituents of the SiiPr3 groups on the Pn†† supporting ligand. One of the hydrogens of this secondary vinylic moiety is significantly shifted upfield in the 1H NMR spectrum of (3) and a single crystal XRD study shows an interaction between this hydrogen and one of the Ti centres. Preliminary kinetic studies of the formation of (3) show a slightly negative entropy of activation and 1st order consumption of (1) both of which suggest the involvement of a Ti-H(iPr) agostic interaction during the cyclometallation reaction.

This paper aims to reconstruct the alluvial activity for the Lilas river, the second-largest catchment of Euboea Island (Central Western Aegean Sea), for approximately the last three and a half millennia. The middle reaches (Gides basin) exhibit several historical alluvial terraces that were first recognised in the 1980s but have remained poorly studied, resulting in uncertain chronological control of palaeofluvial activity. In order to reconstruct the past fluvial dynamics of the Lilas river, a ca. 2.5 m thick stratigraphic profile has been investigated for granulometry and magnetic parameters. Absolute dating of the sediments was possible by applying Optically Stimulated Luminescence (OSL). The results reveal: (i) two coarse-grained aggradational episodes dated from the Mycenaean/Early Iron Age and the Roman periods, respectively, (ii) a phase of rapid fine-grained vertical accretion corresponding to the Late Byzantine to early Venetian periods, (iii) potential evidence for final alluvial deposition from the Little Ice Age/Ottoman period, and (iv) two major incision episodes inferred from Ancient Greek times and most of the Byzantine period. Based on the published core material, the paper also evaluates the direct impacts of the Late Holocene alluviation recorded mid-stream on the fluvial system situated downstream in the deltaic area. Sediment sourcing is attempted based on the magnetic properties of the catchment lithology and of alluvium collected upstream along the main stream bed. Finally, the present paper discusses the possible links between Late Holocene hydroclimatic oscillations and the aggradational/incision phases revealed in the Gides basin. Correlations are attempted with regional palaeoclimate records obtained for the Aegean. In addition to climatic variability, anthropogenic factors are considered: specific land use for agricultural purposes, in particular during the Mycenaean period, the Roman and the Late Byzantine/Early Venetian periods, might have enhanced sediment deposition. Archaeological information and pollen records were also evaluated to reconstruct regional land-use patterns and possible impacts on soil accumulation over the last 3.5 millennia.

Many researchers have addressed problems involving time-varying (TV) general linear matrix equations (GLMEs) because of their importance in science and engineering. This research discusses and solves the topic of solving TV GLME using the zeroing neural network (ZNN) design. Five new ZNN models based on novel error functions arising from gradient-descent and Newton optimization methods are presented and compared to each other and to the standard ZNN design. Pseudoinversion is involved in four proposed ZNN models, while three of them are related to Newton’s optimization method. Heterogeneous numerical examples show that all models successfully solve TV GLMEs, although their effectiveness varies and depends on the input matrix.

In the present paper, the problem of independent control of the speed and orientation of a differential drive mobile robot through wireless networks is studied. Based upon the linear approximant of the nonlinear model of the mobile robot, a multidelay linear I/O decoupling controller is designed. The controller feeds back delayed measurements of all state variables of the system. The analytic form of the precompensator matrix and a part of the elements of the feedback matrix is determined. The remaining controller parameters are metaheuristically evaluated so that appropriate delay stability margins are accomplished. The performance of the proposed control scheme is illustrated through series of computational experiments where it is observed that the nonlinear model behaves satisfactorily for large external commands and uncertain model parameters.

1. RESEARCH IMPACT: 1149 DIRECT CITATIONS //  1149  ΑΝΑΦΟΡΕΣ ΑΠΕΥΘΕΙΑΣ ΣΤΟ ΕΡΓΟ (updated January 17, 2023)

• Pergamos-Thousands of Reads/Accesses in Pergamos-university digital library (Χιλιάδες «Αναγνώσεις» στον ΠΕΡΓΑΜΟ). Ενδεικτικά/example: 1) The Greek Experience: Outstanding Women in the Social Space of Sport 1569  Αναγνώσεις/reads/accesses  https://pergamos.lib.uoa.gr/uoa/dl/object/2332855, 2) Athlete Activism and Peace Education: Bridging the Social Inequality Gap through Sports 1146 Αναγνώσεις/reads   https://pergamos.lib.uoa.gr/uoa/dl/object/2359317 , 3) Interacting, sharing and bonding: ‘notes of personal experience’ by nineteenth-century women travellers  1432 Αναγνώσεις/reads     https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:2330579  4) Women entrepreneurs: ‘we cannot have change unless we have men in the room’ 1337 reads https://pergamos.lib.uoa.gr/uoa/dl/object/2330032 5) Gender integration in the military:Gender-neutral standards and coed sports 464 Reads https://pergamos.lib.uoa.gr/uoa/dl/object/2880107 (last access Oct. 25, 2022).

 

Neurodevelopmental disorders (NDDs) are a heterogeneous group of impairments that affect the development of the central nervous system leading to abnormal brain function. NDDs affect a great percentage of the population worldwide, imposing a high societal and economic burden and thus, interest in this field has widely grown in recent years. Nevertheless, the complexity of human brain development and function as well as the limitations regarding human tissue usage make their modeling challenging. Animal models play a central role in the investigation of the implicated molecular and cellular mechanisms, however many of them display key differences regarding human phenotype and in many cases, they partially or completely fail to recapitulate them. Although in vitro two-dimensional (2D) human-specific models have been highly used to address some of these limitations, they lack crucial features such as complexity and heterogeneity. In this review, we will discuss the advantages, limitations and future applications of in vivo and in vitro models that are used today to model NDDs. Additionally, we will describe the recent development of 3-dimensional brain (3D) organoids which offer a promising approach as human-specific in vitro models to decipher these complex disorders.

Abstract This article examines the proliferation of popular literary texts about Modern Greece in nineteenth-century British periodicals from the 1860s to the 1890s, texts that reveal the country's appeal to the Victorians, inviting them to imagine the birth and development of the new nation after the War of Independence (1821?1828). Short stories published in popular magazines, such as the New Monthly Magazine, Bow Bells and Sunday at Home, revisit the Greek Revolution and return to the popular allegory of Greece as an enslaved or endangered woman to reflect on the ?Eastern question? and British colonial politics of protectionism in the Eastern Mediterranean. At the same time, women authors like Elizabeth Mayhew Edmonds and Isabella Fyvie Mayo, publishing in women's magazines, write stories and articles about the role of women in the Greek War of Independence, relating the feats of these historical or fictional figures to the ?woman question? and to Victorian debates on femininity and gender, as well as national and imperial politics. In the late Victorians' re-imagining of revolutionary history, Modern Greece is not enslaved to its classical past, as in traditional philhellenist representations, but must discover its modernity through its powerful nationalist agents. Revolutionary Greece re-emerges as a symbolic event through a variety of publications, which often highlight the country's cultural hybridity and construct a transnational network of literary affiliations, creating parallelisms between Greece and Britain.

Purpose To develop physiologically based finite time pharmacokinetic (PBFTPK) models for the analysis of oral pharmacokinetic data. Methods The models are based on the passive drug diffusion mechanism under the sink conditions principle. Up to three drug successive input functions of constant rate operating for a total time tau are considered. Differential equations were written for all these models assuming linear one- or two-compartment-model disposition. The differential equations were solved and functions describing the concentration of drug as a function of time for the central and the peripheral compartment were derived. The equations were used to generate simulated data and they were also fitted to a variety of experimental literature oral pharmacokinetic data. Results The simulated curves resemble real life data. The end of the absorption processes tau is either equal to t(max) or longer than t(max) at the descending portion of the concentration time curve. Literature oral pharmacokinetic data of paracetamol, ibuprofen, almotriptan, cyclosporine (a total of four sets of data), and niraparib were analyzed using the PBFTPK models. Estimates for tau corresponding to a single or two or three different in magnitude input rates were derived along with the other model parameters for all data analyzed. Conclusions The PBFTPK models are a powerful tool for the analysis of oral pharmacokinetic data since they rely on the physiologically sound concept of finite absorption time.

This study presents the preliminary results of selected samples from Aggelokastro section, Argolida, Greece. The section is comprised of a ~200m thick carbonate sedimentary succession, capped by ~50m of clastic sediments of the “schist-sandstone-chert” formation. The entire sedimentary sequence belongs to the Sub-Pelagonian type B Unit, member of the tectonostratigraphic terrain H3, equivalent to the non-metamorphic Pelagonian platform (Papanikolaou, 1990; Papanikolaou, 2021). In total 12 thin sections were produced from selected samples and studied under the microscope. Each sample was characterized according to the Standard Microfacies (SMF) scheme of Flugel (2010). The results show significant diversion between paleoenvironmental conditions and are divided into three main parts (see Fig. 1): -          Lower formation: shallow water carbonate succession with densely packed peloidal packstones-grainstones with coated benthic foraminifera (Orbitopsella and others), gastropods and echinoids (SMF 11, platform margin shoals or platform margin reef) and wackestones with gastropods, benthic foraminifera and algae (SMF 8, open marine-interior platform) -          Middle formation: transitional (slope) environment carbonates, represented by a polymictic breccia grading to wackestone with subangular-subrounded lithoclasts and bioclasts (shell debris, radiolaria, benthic foraminifera and large bivalve shells) (SMF 4, slope or toe-of-slope) and -          Upper formation: deep marine environment carbonates, including Ammonitico Rosso facies, represented by wackestones-packstones with spicules, thin shelled bivalves, radiolaria and planktonic foraminifera (SMF 1 and 3, deep shelf or deep sea). Additionally, smear slides from the “flysch-like” succession point to a deep marine clastic environment with rare or absent carbonate material. The defined Standard Microfacies show a clear deepening upward trend, marking the rifting of the carbonate platform. Regarding geological age considerations, the lower formation should be considered as Early Jurassic (late Sinemurian – middle/late Plienbachian) due to the presence of Orbitopsella sp. (Ogg et al., 2016). The Ammonitico Rosso facies of the upper formation is tentatively attributed to Middle Jurassic, similarly to the dating of radiolarites above the carbonate platform (Danelian and Robertson, 1995) in Beotia area. Lastly, the “flysch-like” clastic succession is generally considered of Late Jurassic-Early Cretaceous age, according to Papanikolaou (1990).

Transversal structural elements in cross-striated muscles, such as the M-band or the Z-disc, anchor and mechanically stabilize the contractile apparatus and its minimal unit-the sarcomere. The ability of proteins to target and interact with these structural sarcomeric elements is an inevitable necessity for the correct assembly and functionality of the myofibrillar apparatus. Specifically, the M-band is a well-recognized mechanical and signaling hub dealing with active forces during contraction, while impairment of its function leads to disease and death. Research on the M-band architecture is focusing on the assembly and interactions of the three major filamentous proteins in the region, mainly the three myomesin proteins including their embryonic heart (EH) isoform, titin and obscurin. These proteins form the basic filamentous network of the M-band, interacting with each other as also with additional proteins in the region that are involved in signaling, energetic or mechanosensitive processes. While myomesin-1, titin and obscurin are found in every muscle, the expression levels of myomesin-2 (also known as M-protein) and myomesin-3 are tissue specific: myomesin-2 is mainly expressed in the cardiac and fast skeletal muscles, while myomesin-3 is mainly expressed in intermediate muscles and specific regions of the cardiac muscle. Furthermore, EH-myomesin apart from its role during embryonic stages, is present in adults with specific cardiac diseases. The current work in structural, molecular, and cellular biology as well as in animal models, provides important details about the assembly of myomesin-1, obscurin and titin, the information however about the myomesin-2 and -3, such as their interactions, localization and structural details remain very limited. Remarkably, an increasing number of reports is linking all three myomesin proteins and particularly myomesin-2 to serious cardiovascular diseases suggesting that this protein family could be more important than originally thought. In this review we will focus on the myomesin protein family, the myomesin interactions and structural differences between isoforms and we will provide the most recent evidence why the structurally and biophysically unexplored myomesin-2 and myomesin-3 are emerging as hot targets for understanding muscle function and disease.

We measured SARS-CoV-2 RNA load in raw wastewater in Attica, Greece, by RT-qPCR for the environmental surveillance of COVID-19 for 6 months. The lag between RNA load and pandemic indicators (COVID-19 hospital and intensive care unit (ICU) admissions) was calculated using a grid search. Our results showed that RNA load in raw wastewater is a leading indicator of positive COVID-19 cases, new hospitalization and admission into ICUs by 5, 8 and 9 days, respectively. Modelling techniques based on distributed/fixed lag modelling, linear regression and artificial neural networks were utilized to build relationships between SARS-CoV-2 RNA load in wastewater and pandemic health indicators. SARS-CoV-2 mutation analysis in wastewater during the third pandemic wave revealed that the alpha-variant was dominant. Our results demonstrate that clinical and environmental surveillance data can be combined to create robust models to study the on-going COVID-19 infection dynamics and provide an early warning for increased hospital admissions.

Pocket beaches are a large part of the Greek coastline, with strong touristic, economic and natural interest. Their morphological characteristics and wave forcing are the main factors influencing their evolution, while the most commonly observed dynamic is beach rotation due to prevailing wave direction. Human activities and climate change call for a better management for these areas, necessitating, therefore, the identification of coastal geomorphodynamic processes. This paper focuses on the geomorphological and sedimentological dynamic processes of Platis Gialos Bay (Sifnos), which have given rise to the present setting. Beach orientation, slope, length, geology, Posidonia Oceanica, degree of embayment, sedimentology and closure are some parameters that must be considered to calculate the morphodynamic and stability indicators that prevail at the beach. Wave exposure forcing conditions, longshore – rip current direction, are also hydrodynamic processes to be determined, as they play a significant role in sediment transport. A number of methodologies took place in order to determine the level of disturbance of this dynamic equilibrium, which included morphological mapping, sedimentary classification, shoreline displacement/evolution monitoring, hydrodynamic and sedimentary modelling. The exposure of the coast to the southern waves, the reduced sediment supply from the local fluvial network, human activities and the construction of the fishing shelter have led the area to a continuous erosion and coastline retreat in its western and central part, in contrast to the eastern part, where there is a continuous deposition reflected by coastal accretion and the formation of a shallow environment.

On the basis of self-determination theory, we aimed to identify students’ perceptions of interpersonal teaching style profiles (i.e. within-teacher combinations of six dimensions of need-supportive and need-thwarting behaviours of autonomy, competence and relatedness) and to examine, through a cross-sectional design, the possible associations between these teaching profiles and students’ behavioural and emotional engagement. Participants were 2065 students (nteachers = 38) of Physical Education (PE) (Mage = 11.96 ± 1.95; range = 10–16 years; 1042 girls) nested in 98 classrooms from elementary (n = 915) and secondary (n = 1150) Spanish schools. Students filled out questionnaires in a paper and pencil format during the last semester of the school year. A four-cluster solution was found to be the most suitable: (a) a high-low group (i.e. high in perceived need-support and low in need-thwarting), (b) a low-high group (i.e. low in perceived need-support and relatively high in need-thwarting), (c) a low-low group (i.e. low in both need-support and need-thwarting) and (d) a mixed group (i.e. low in autonomy support, high in autonomy-thwarting and relatively modest-to-high in competence and relatedness support and thwarting). A multivariate analysis of variance (MANOVA) indicated significant differences in students’ behavioural and emotional engagement as a function of cluster membership. Post hoc comparisons showed that the high-low group reported the highest levels of engagement and the low-high group the lowest ones. Furthermore, the mixed group scored the second highest level of engagement – higher than the low-low and the low-high group. These results suggest that teachers who fail to support students’ needs for autonomy, competence and relatedness – either by using or not using need-thwarting instructional practices – might undermine students’ engagement.

Seismicity in the Ionian Sea (W. Greece) is mainly generated along the Cephalonia–Lefkada Transform Fault Zone (CLTFZ) in the central Ionian, and on the northwestern termination of the Hellenic subduction margin in the south. Joint pre-, co- and post-seismic ground deformation and seismological analysis is performed at the broad Ionian area, aiming to homogeneously study the spatiotemporal evolution of the activity prior to and after the occurrence of strong (M > 6) earthquakes during the period of 2014–2018. The 2014 Cephalonia earthquakes (Mw6.1 and Mw5.9) were generated on a faulting system adjacent to CLTFZ, causing local ground deformation. The post-seismic sequence is coupled in space and time with the 2015 Lefkada earthquake (Mw6.4), which occurred on the Lefkada segment of the CLTFZ. Co-seismic displacement was recorded in the broader area. Seismicity was concentrated along the CLTFZ, while its temporal evolution lasted for several months. The 2018 Zakynthos earthquake (Mw6.7) caused regional deformation and alterations on the near-velocity field, with the seismicity rate remaining above background levels until the end of 2021. In the northern Ionian, convergence between the Apulian platform and the Hellenic foreland occurs, exhibiting low seismicity. Seismic hazard assessment revealed high PGA and PGV expected values in the central Ionian.

In early March 2021, three shallow earthquakes, two mainshocks with M6.3 and M6.0 and one major aftershock with M5.6 impacted both the mountainous Damasi-Tyrnavos region (northern Thessaly, Greece) and the adjacent Plio-Quaternary basin. Each major event was followed by rich aftershock activity recorded by local and regional seismographs and accelerographs. Herein, we present a comprehensive analysis of the seismic sequence, from its foreshock activity starting on 28 February, 2021 and for a period of two months using new high-resolution catalogues of relocated earthquakes and hundreds of focal mechanisms. The results indicate that the aftershocks form a zone that spans ~50 km NW-SE, while focal depths range between 5 and 15 km. More than 400 focal mechanisms, computed for events with M≥ 2.5, mainly exhibit normal faulting in a NW-SE direction, while WNW-ESE to E-W normal faulting is also evidenced, in particular after the occurrence of the last major event on 12 March. The stress-field was reconstructed on a local and broader scale by inverting focal mechanism data, revealing a rotation of the σ3 axis trend from NNE-SSW, in the Damasi-broader region, to NW-SE northwards, to the region of Kozani-Grevena that hosted an Mw = 6.6 shallow mainshock in 1995. Subcrustal seismicity, present beneath those areas, implies that large-scale tectonics and plate dynamics are likely involved in the deformation of the upper crust. Coulomb stress transfer after the 3 major events of the 2021 Damasi-Tyrnavos sequence reveals that stress-loaded areas include those where most aftershocks were triggered. The analysis provides implications to the seismic hazard of the activated area, as a major NW-SE active normal fault close to Larissa city became stress-loaded, constituting a possible candidate source for significant future earthquakes.

Treatment of neuropsychiatric disorders relies on the effective delivery of therapeutic molecules to the target organ, the brain. The blood-brain barrier (BBB) hinders such delivery and proteins acting as transporters actively regulate the influx and importantly the efflux of both endo- and xeno-biotics (including medicines). Neuropsychiatric disorders are also characterized by important sex differences, and accumulating evidence supports sex differences in the pharmacokinetics and pharmacodynamics of many drugs that act on the brain. In this minireview we gather preclinical and clinical findings on how sex and sex hormones can influence the activity of those BBB transporter systems and affect the brain pharmacokinetics of psychotropic medicines. It emerges that it is not well understood which psychotropics are substrates for each of the many and not well-studied brain transporters. Indeed, most evidence originates from studies performed in peripheral tissues, such as the liver and the kidneys. None withstanding, accumulated evidence supports the existence of several sex differences in expression and activity of transport proteins, and a further modulating role of gonadal hormones. It is proposed that a closer study of sex differences in the active influx and efflux of psychotropics from the brain may provide a better understanding of sex-dependent brain pharmacokinetics and pharmacodynamics of psychotropic medicines.

The complexity of show caves and the problems arising through human interaction with them, require interdisciplinary approaches capable of synthesizing a range of parameters such as knowledge, methods and provided tools to promote geo-ethical thinking and geoscientists contribution for sustainable management. Show caves are tourist/commercial caves which have been accessible to the public with artificial lighting, shaped paths, guided tours, open hours and they are considered as heritage sites. The concept of heritage is a complex idea, controversial and culturally constructed, depending on the personal and collective background and experiences of the members of a society. Heritage is often artificially divided into natural and cultural, but regarding the “show caves” as entities, the boundaries are indistinguishable. Moreover, show caves suffer successive degradation for several interconnected reasons. This work analyzes proposals for compilation of protocols and general management that may involve educational institutes, management agencies, policy makers and stakeholders based on remotely monitored parameters and scientific data collection, for feeding assessment and evaluation tools. The main scope is to arouse a wider dialogue of the interested parts with the aim to form the basis for the creation of a European legislation for protecting these sensitive but also complex environments through geo-conservation and geo-ethics approaches.

Metal-Insulator-Semiconductor micro-capacitors for on-chip energy storage were fabricated and characterized. The capacitors were based on Si nanowires fabricated by Metal Assisted Chemical Etching. 1.2μm long nanowires with 100nm average diameter were created leading to an effective area increase of 6.28, as compared to a flat surface. Nanowires were chemically treated to reduce surface roughness and electronic states and were coated by a HfO2 layer, deposited by Atomic Layer Deposition, to act as the dielectric. Al and Cu were deposited as two possible top metal electrodes. The use of Al as the top electrode was shown to create a parasitic interface oxide between the metal and the dielectric, reducing the measured capacitance. The use of Cu was shown to significantly reduce this problem, leading to more efficient devices. Capacitors with 5.4μF/cm2 capacitance and 8.9x10-7A/cm2 leakage current at -2.5V were demonstrated along with a cutoff frequency of 104Hz. These values make the demonstrated capacitors very attractive for on-chip energy storage applications.

Myrtos Beach (Cephalonia Island, Ionian Sea, Greece) represents a pocket beach with strong touristic, economic and natural interest. In this research, the morphodynamic behavior of the coastal area (e.g., hydrodynamic and sedimentary state, morphology, orientation, etc.), the current wave conditions (extreme and dominant waves, wave exposure), and also external factors, such as human impact and the geotechnical condition of the wider area, are examined. Short- and medium-to-long-term analysis took place, such as mapping, sediment analysis, wave/wind analysis, numerical modeling, and satellite monitoring, in order to identify the dynamic forcing parameters related to geomorphology, sedimentology, and hydrology that prevail in the area. Additionally, the intense tectonics, the karstified limestones, and the steep slopes of the cliffs in combination with the frequent seismic events on the island set up a geotechnically unstable area, which often cause landslides on the beach of Myrtos; these supply the beach with a large amount of aggregates, constituting the main sediment supply. Wave exposure forcing conditions, longshore–rip current direction, and other hydrodynamic processes are stable with high values in the area, causing notable sediment transport within the bay boundaries. As a result, at Myrtos Bay there is a dynamic balance of the natural system, which is directly affected by human interventions. Taking also into consideration that Myrtos is one of the most famous beaches in Greece and one of the main attractions of Cephalonia Island with thousands of visitors every year, beach management must be focused on preserving the natural system of the coastal area.

The role of the crystal lattice, temperature and magnetic field for the spin structure formation in the 2D van der Waals magnet Fe5GeTe2 with magnetic ordering up to room temperature is a key open question. Using Lorentz transmission electron microscopy, we experimentally observe topological spin structures up to room temperature in the metastable pre-cooling and stable post-cooling phase of Fe5GeTe2. Over wide temperature and field ranges, skyrmionic magnetic bubbles form without preferred chirality, which is indicative of centrosymmetry. These skyrmions can be observed even in the absence of external fields. To understand the complex magnetic order in Fe5GeTe2, we compare macroscopic magnetometry characterization results with microscopic density functional theory and spin-model calculations. Our results show that even up to room temperature, topological spin structures can be stabilized in centrosymmetric van der Waals magnets.

The study examines which type of religious knowledge acquired in Religious Education in Greek Secondary schools can initiate both personal and collective change in understanding and appreciation of different cultures. It is blended research using participatory action-research with ethnographic elements methodology. The research gathered qualitative and quantitative data through questionnaires, focus groups, journals, and the technique of the “Most Significant Change” from four resources/target groups (students, teachers, parents, researcher). It took place during the 2017–2018 school year in a High and an Upper Schools in which the researcher participated in the school communities as a teacher. Statistical analysis (SPSS), content analysis and thematic analysis of the data show that religious knowledge, developed in Education with the aim of religious literacy, as defined in the context of Greek/European context, can operate on a personal and collective level, in cultivation of respect and underacting of cultural diversity. This is achieved when the religious knowledge is understood as experience and is meaningful when applied to the concepts of understanding, reflection and action. The overall finding is that transformative dynamics of religious knowledge facilitate both minor and major changes in the mindset of young people. Concluding, in Religious Education without sacrificing the religious content of the subject, a high degree of cultural recognition and acceptance of religious diversity can be achieved, and to a certain extent enable a change in attitude towards immigrants and refugees, in other words the ‘other’ as well as in communication and acquaintance between team members, recognition of and a greater degree of acceptance of otherness, and the development of relationships which were non-existent before.

Οι κοινωνικά ευπαθείς ομάδες αντιμετωπίζουν μεγαλύτερο κίνδυνο για φτώχεια ή κοινωνικό αποκλεισμό σε σχέση με τον γενικό πληθυσμό, είτε λόγω ανα­ πηρίας, είτε λόγω ηλικίας, προέλευσης, αστεγίας, κατάχρησης ουσιών ή/και εγκλεισμού. Στις κοινωνικά ευπαθείς ομάδες εντάσσονται και παιδιά που αντι­ μετωπίζουν κοινωνικά προβλήματα καθώς και νέοι ηλικίας 16­25 ετών που βρί­ σκονται εκτός εκπαίδευσης, εργασίας και κατάρτισης. Καθοριστικό ρόλο στις μορφές αποκλεισμού παιδιών ηλικίας 0­17 ετών διαδραματίζει το μορφωτικό επίπεδο των γονέων. Σύμφωνα με την Eurostat (2021), στην Ελλάδα σήμερα το 74.4% των παιδιών υπο­εκπαιδευμένων γονέων κινδυνεύει από κοινωνικό αποκλεισμό. Την εποχή του ψηφιακού μετασχηματισμού εμφανίζονται και νέα ζητήματα, προκλήσεις και κίνδυνοι για «διπλό αποκλεισμό», τόσο κοινωνικό όσο και ψηφιακό, με τις αντίστοιχες συνέπειες για τις προοπτικές εκπαίδευσης και εργασίας σημαντικής μερίδας του πληθυσμού. Στην προσπάθεια αντιμετώ­ πισης του κοινωνικού αποκλεισμού και πρόληψης του ‘διπλού αποκλεισμού ́, στόχος των προγραμμάτων διά βίου μάθησης είναι η αύξηση των δυνατοτή­ των πρόσβασης στην εκπαίδευση ειδικά για τα άτομα που βρίσκονται εκτός του τυπικού εκπαιδευτικού συστήματος. Ωστόσο, τα εμπόδια είναι σημαντικά και αφορούν διαφορετικά θεσμικά και στρατηγικά επίπεδα. Ή παρούσα εργα­ σία διερευνά τα παραπάνω θέματα καθώς και τις προκλήσεις και τις προοπτι­ κές που αναδύονται στην σύγχρονη εποχή.

This work summarizes the main characteristics of atmospheric and hydro-physical parameters of the water surface derived from microwave radiometric data. First, current knowledge based on experimental measurements and model calculations of emissivity of the atmosphere and water surface in the microwave spectrum is presented. Emphasis is placed on remote radio-physical methods that have the peculiarity of being related to atmospheric radio-transparency which is one of the main advantages of the microwave radiometric method compared to optical and infrared methods. A detailed presentation is attempted with specific examples of classification of water surface phenomena using software modules included in the system used for the processing of data of radio-physical experiments by the Cosmos-1500 satellite. In addition, the statistical characteristics of the “spotting” of radio-brightness temperatures obtained for the most informative thresholds are analyzed and it is argued that these characteristics for the Pacific areas can also be used to detect abnormal phenomena on the water surface of the Mediterranean Sea. Finally, it is emphasized that the results obtained from this work make it possible to rapidly evaluate various parameters such as temperature, water surface waves, foam formation areas, etc., providing predictions and allocating irregular areas.

Photovoltaic (PV) power production is characterized by high variability due to short-term meteorological effects such as cloud movements. These effects have a significant impact on the incident solar irradiance in PV parks. In order to control PV park performance, researchers have focused on Computer Vision and Deep Learning approaches to perform short-term irradiance forecasting using sky images. Motivated by the task of improving PV park control, the current work introduces the Image Regression Module, which produces irradiance values from sky images using image processing methods and Convolutional Neural Networks (CNNs). With the objective of enhancing the performance of CNN models on the task of irradiance estimation and forecasting, we propose an image processing method based on sun localization. Our findings show that the proposed method can consistently improve the accuracy of irradiance values produced by all the CNN models of our study, reducing the Root Mean Square Error by up to 10.44 W/m2">2 for the MobileNetV2 model. These findings indicate that future applications which utilize CNNs for irradiance forecasting should identify the position of the sun in the image in order to produce more accurate irradiance values. Moreover, the integration of the proposed models on an edge-oriented Field-Programmable Gate Array (FPGA) towards a smart PV park for the real-time control of PV production emphasizes their advantages.

The classical “time-bandwidth” limit for linear time-invariant (LTI) devices in physics and engineering asserts that it is impossible to store broadband propagating waves (large &#x0394;&#x03C9;">Δω’s) for long times (large Δt’s). For standing (non-propagating) waves, i.e., vibrations, in particular, this limit takes on a simple form, &#x0394;t&#x0394;&#x03C9;=1">ΔtΔω=1, where &#x0394;&#x03C9;">Δω is the bandwidth over which localization (energy storage) occurs, and &#x0394;t">Δt is the storage time. This is related to a well-known result in dynamics, namely that one can achieve a high Q-factor (narrowband resonance) for low damping, or small Q-factor (broadband resonance) for high damping, but not simultaneously both. It thus remains a fundamental challenge in classical wave physics and vibration engineering to try to find ways to overcome this limit, not least because that would allow for storing broadband waves for long times, or achieving broadband resonance for low damping. Recent theoretical studies have suggested that such a feat might be possible in LTI terminated unidirectional waveguides or LTI topological “rainbow trapping” devices, although an experimental confirmation of either concept is still lacking. In this work, we consider a nonlinear but time-invariant mechanical system and demonstrate experimentally that its time-bandwidth product can exceed the classical time-bandwidth limit, thus achieving values both above and below unity, in an energy-tunable way. Our proposed structure consists of a single-degree-of-freedom nonlinear oscillator, rigidly coupled to a nondispersive waveguide. Upon developing the full theoretical framework for this class of nonlinear systems, we show how one may control the nonlinear flow of energy in the frequency domain, thereby managing to disproportionately decrease (increase) &#x0394;t">Δt, the storage time in the resonator, as compared with an increase (decrease) of the system’s bandwidth &#x0394;&#x03C9;">Δω. Our results pave the way toward conceiving and harnessing hitherto unattainable broadband and simultaneously low-loss wave-storage devices, both linear and nonlinear, for a host of key applications in wave physics and engineering.

Topological features, in particular distinct band intersections known as nodal rings, usually requiring three-dimensional structures, have now been demonstrated experimentally in an elegantly simple one-dimensional photonic crystal.

Η παρούσα εργασία εστιάζει στην αξιοποίηση της σπειροειδούς μάθησης, των ομάδων κατάρτισης καθώς και της προσομοίωσης ως σημαντικών εργαλείων για την ένταξη στο χώρο εργασίας. Η εργασία αναδεικνύει τις δυνατότητες αξιοποίησης των παραπάνω μεθόδων και εργαλείων στην περίοδο της πανδημίας και της ψηφιακής αλλαγής. Παρουσιάζονται τα στάδια και οι βασικές παράμετροι της σπειροειδούς μάθησης, τα παιχνίδια προσομοίωσης στον κύκλο των διδακτικών πρακτικών και μεθόδων καθώς και οι ομάδες κατάρτισης (Τ-groups). Η εργασία προτείνει παραδείγματα και καλές πρακτικές τόσο από το χώρο της τριτοβάθμιας εκπαίδευσης όσο και από το χώρο των οργανισμών και ένα μοντέλο εκπαίδευσης προσαρμοσμένο σε πραγματικές εργασιακές συνθήκες.

After 1981, with Greece’s accession into the European Economic Community (EEC), as today’s European Union (EU) was called at the time, the Greek diasporic phenomenon was transformed and the Greek theatrical mobility was mainly related to the recruitment of Greek officials to the EU institutions and organizations. For the next 40 years, the Greek Diasporic Community Theater (DCT) of Brussels has become a participatory field of integration and Greek troupes have begun to proliferate, influenced by the demographic, ideological, and socio-structural changes that have taken place both in Greece and Belgium in recent decades. The present paper studies and presents the causes of the artistic resilience of the Greek Diasporic Community Theater (DCT) in Brussels. The case of the Greek DCT in Brussels is such a unique case of DCT, which operates continuously and systematically from the early 1980s until today, flourishing and presenting unprecedented signs of resilience. 

In volleyball, the performance in the passing affects the setter’s strategy and the effectiveness of the attack after the reception or defense. This study aims to assess the spatial and temporal characteristics of the setting choices made by junior female volleyball setters and their performance concerning the origin of the ball and the game complex. The sample for this analysis consists of 3728 setting actions (Complex I = 1.616, Complex II = 1.212). A three-member group of experienced coaches assessed the setting zones’ choices as well as the setting tempo and the performance of junior female setters from 20 volleyball games of teams competing in the final phase of the Greek Junior Championship. The variables under consideration were complex of the game (C1 & CII), origin of the ball (left/middle/right lane for the vertical and front/centre/back lane for the horizontal axis of the court), setting zone (six zones of the court), setting tempo (1st, 2nd & 3rd tempo) and setting performance in a five-level ordinal scale. Inter-rater and intra-rater reliability coefficients were estimated using Cohen’s kappa coefficient with acceptable values. The test of independence for the categorical variables was carried out using the chisquare test. Following the overall independence test, the difference in proportions among all levels of variables was tested. Results showed that junior female setters regardless of the complex and the origin of the ball choose zone 4 in a 3rd tempo, performed in a moderate and good setting. However, the origin of the ball was an important variable for the subsequent setting. The most preferable route of the ball was from a pass in the left lane of the court to an attack in zone 4 regardless of the game complex. Additionally, setters when receiving the ball from the left and middle lane of the court prefer more often zone 3 in 1st tempo, during CI than CII. The results of the study will give useful directions to the coaches of the specific age category regarding the creation of appropriate training programs for the individual improvement of the setters and teams.

Eight years after the first detection of high-energy astrophysical neutrinos by IceCube, we are still almost clueless as regards to their origin, although the case for blazars being neutrino sources is getting stronger. After the first significant association at the $3\!-\!3.5\, \sigma$ level in time and space with IceCube neutrinos, i.e. the blazar TXS 0506+056 at z = 0.3365, some of us have in fact selected a unique sample of 47 blazars, out of which ~16 could be associated with individual neutrino track events detected by IceCube. Building upon our recent spectroscopy work on these objects, here we characterize them to determine their real nature and check if they are different from the rest of the blazar population. For the first time we also present a systematic study of the frequency of masquerading BL Lacs, i.e. flat-spectrum radio quasars with their broad lines swamped by non-thermal jet emission, in a γ-ray- and IceCube-selected sample, finding a fraction >24 per cent and possibly as high as 80 per cent. In terms of their broad-band properties, our sources appear to be indistinguishable from the rest of the blazar population. We also discuss two theoretical scenarios for neutrino emission, one in which neutrinos are produced in interactions of protons with jet photons and one in which the target photons are from the broad-line region. Both scenarios can equally account for the neutrino-blazar correlation observed by some of us. Future observations with neutrino telescopes and X-ray satellites will test them out.

The exchange rate dynamics affect national economies because fluctuations in currency prices distort their economic activity. To maintain an optimal exchange rate policy, these dynamics are crucial for countries with a trade economy. Due to the difficulty in predicting the participants behavior in some complex economic systems, which might throw the system into chaos, a novel stochastic exchange rate dynamics (SERD) model is introduced and investigated in this paper. Furthermore, a neural network approach is proposed and examined as a control chaos method to address the problem of stabilizing SERD through central bank interventions. Derived from power activation feed-forward neuronets, a 2-input weights-and-structure-determination-based neuronet (2I-WASDBN) model for controlling chaos in SERD under central bank intervention is presented in this paper. Six simulation experiments on stabilizing the chaotic behavior of the SERD model show that the 2I-WASDBN model outperforms other well-performing neural network models and that it is more effective than traditional methods for controlling chaos. By examining the volume of necessary intervention predicted by the 2I-WASDBN model, central banks can better comprehend exchange rate fluctuations and, in conjunction with their monetary policies, can make more precise decisions regarding the strategy of their interventions.

This paper examines the positions of the Greek-speaking Orthodox Churches concern- ing Russia’s ongoing war against Ukraine. Apart from being informative, the paper raises the theological question about whether the Churches’ various stances follow Christ’s commandment to spread his teaching to the world and to what degree they are compatible with relevant New Testament texts. After navigating through and commenting on the relevant statements of the Patriarchates of Constantinople, Al- exandria, and Jerusalem, the Autocephalous Churches of Cyprus and Greece, and the Holy Community of Mount Athos, two New Testament texts that represent different approaches to political power, namely Rom 13:1–7 and John’s Revelation, are briefly examined. The paper establishes that the positions of the Greek-speaking Churches vary between general anti-war statements and concrete condemnations of the Russian invasion and its direct or indirect support by the Russian Orthodox hi- erarchy. However, nationalism, as well as church-political opportunism, seem to be more or less inherent phenomena in all contemporary national Orthodox Churches. Hence, finally, it is up to the faithful, not just to Church hierarchies, to discern evil and speak out against injustice.

Dedicated to the historical and cultural heritage of Lemnos, the book offers a new, valid, concise and accessible history of this unique Greek island in the Northeast Aegean. Based on historical and mythological sources, archaeological finds, important remains of ancient Greek, medieval and modern art, narratives and chronicles, engravings, drawings, photographs and other archival material, the author sketches in 250 pages and with the help of about 200 images, the history of Lemnos from the depths of the Aegean prehistory to the present day. In its pages, readers will find important information about the society, the economy, the political life, the art and the intellectual creation of the island over time, from the first nomadic settlements during the late Paleolithic period (ca. 10,500 BC), until today: with extensive accounts of the prehistoric cities of Poliochni and Myrina, the important site of Koukonisi, Hephaestia and Kaveirion during the Archaic and Classical period (7th-4th century BC), Lemnos of the Hellenistic and Roman years, Lemnos as a Byzantine, Venetian, and Ottoman possession, but also the adventures of the island and its inhabitants from the liberation of 1912-13 onwards.

Christa Wolf hat Literatur immer als ideologiekritisches Medium betrachtet, um Erinnerungskultur und Erinnerungsmythen zu hinterfragen. Dazu muss man mit den Gespenstern sprechen. Dies geschieht durch die Schaffung von Texten, die mit den Grenzen der Sprache experimentieren. Die vorliegende Studie geht davon aus, dass der Roman Leibhaftig der ehrlichste und zugleich erfolgreichste Versuch der Autorin in dieser Richtung ist, ein erzählerisches Experiment, das darauf abzielt, "die Grenzen des Sagbaren zu überschreiten". Die Erzählung ist ein multiperspektivisches polyvokales literarisches Netzwerk. Spielerisch experimentiert der Autor in zwei Richtungen: mit verschiedenen zeitlichen Perspektiven und mit verschiedenen Formen von Erzähler und Erzählperspektive. Die Struktur der Erzählung ist multitemporal. Die Ebene einer extradiegetisch-homodiegetischen Erzählinstanz in der Gegenwart wird mit Erinnerungen aus rund sechzig Jahren Vergangenheit sowie aus der gesamten Menschheitsgeschichte verwoben. Außerdem wird die Geschichte in zwei Erzählstimmen erzählt, sowohl in der ersten als auch in der dritten Person, wobei der Wechsel oft mitten im Satz stattfindet. Das Ergebnis ist ein offener Text, der sich nicht scheut, die Wunde offen zu lassen, mit den eigenen wie mit den kollektiven Phantomen abzurechnen.

I. «1922-2022, 100 ΧΡΟΝΙΑ ΑΠΟ ΤΗ ΜΙΚΡΑΣΙΑΤΙΚΗ ΚΑΤΑΣΤΡΟΦΗ. ΙΣΤΟΡΙΚΗ ΑΠΟΤΙΜΗΣΗ, ΕΘΝΙΚΟΣ ΑΝΑΣΤΟΧΑΣΜΟΣ» της Ευξείνου Λέσχης Θεσσαλονίκης (Βραβείο Ακαδημίας Αθηνών).   Ενότητα «Πολιτισμός και Τέχνες στη Μ. Ασία και τον Πόντο»:

• YouTube-live streaming 21/2/2022    https://youtu.be/fuYH96ayNTU

  1ο webinar με  ομιλητές την Ειρήνη Καμπερίδου και τον Βασίλειο Καρφή. Το πρόγραμμα στο HUB του ΕΚΠΑ:  https://hub.uoa.gr/lecture-series-kamperidou-karfis/ Παρακολουθήστε στο YouTube: https://youtu.be/fuYH96ayNTU)   1) «Ο Kινητικός Πολιτισμός των Ελλήνων: Ο χορός, η εκμάθηση μουσικών οργάνων και η εκγύμναση ως “σύμβολα κατωτερότητας” στην οθωμανική κοινωνία» Ομιλήτρια : Ειρήνη Καμπερίδου, Καθηγήτρια Κοινωνιολογίας του ΕΚΠΑ   2) « Σκοποί, χοροί και μνήμες της καθ’ ημάς Ανατολής: Χαρτογράφηση των χορών των Ελλήνων της περιοχής», Oμιλητής : Βασίλειος Καρφής, Διδάκτωρ και Διδάσκων του ΕΚΠΑ,  ερευνητής του Ελληνικού παραδοσιακού χορού Τη διάλεξη μπορείτε να παρακολουθήσετε YouTube: https://youtu.be/fuYH96ayNTU   II. Η ΠΑΓΚΟΣΜΙΑ ΔΙΑΣΤΑΣΗ ΤΗΣ ΕΛΛΗΝΙΚΗΣ ΕΠΑΝΑΣΤΑΣΗΣ ΚΑΙ Η ΣΥΜΜΕΤΟΧΗ ΤΩΝ ΓΥΝΑΙΚΩΝ: ΚΙΝΗΤΙΚΟΣ ΠΟΛΙΤΙΣΜΟΣ, ΑΘΛΗΤΙΣΜΟΣ  ΚΑΙ ΕΛΛΗΝΙΚΟΤΗΤΑ

• 1ο webinar (26/11/2021): https://youtu.be/1p19Px3Nb6w
• 2ο webinar (17/12/2021): https://youtu.be/54LEIAaPEg4

    III.  ΠΑΡΕΝΟΧΛΗΣΗ, ΦΥΛΟ ΚΑΙ ΑΘΛΗΤΙΣΜΟΣ

• 1ο webinar (5 Μαρτίου 2021): https://youtu.be/LtNeMaGAs64
• 2ο webinar (9 Απριλίου 2021 ): https://www.youtube.com/watch?v=GtZMRbK_6q4
• 3ο webinar (14 Μαΐου 2021): https://youtu.be/1zQZ_WylO3c

          Επίσης, βλέπε ΣΕΦΑΑ/ΤΕΦΑΑ, ΕΚΠΑ: http://www.phed.uoa.gr/ak-draseis/webinars.html    IV. Η ΘΕΣΗ ΤΗΣ ΕΛΛΗΝΙΔΑΣ ΚΑΤΑ ΤΗ ΠΕΡΙΟΔΟ ΤΗΣ ΤΟΥΡΚΟΚΡΑΤΙΑΣ [συνέδριο]

• YouTube  (27 Σεπτεμβρίου 2021): https://m.youtube.com/watch?v=mSd-jE00mLg  2η Συνεδρία: "Η θέση της Ελληνίδας κατά την περίοδο της Τουρκοκρατίας" - YouTube :

Ειρήνη Καμπερίδου (2021). Η ΑΠΟΜΥΘΟΠΟΙΗΣΗ ΤΟΥ ΧΑΡΕΜΙΟΥ: Η ΠΟΛΥΕΘΝΙΚΗ ΔΟΥΛΕΙΑ ΤΟΥ ΟΘΩΜΑΝΙΚΟΥ ΧΑΡΕΜΙΟΥ ΚΑΙ ΤΟ ΓΥΝΑΙΚΕΙΟ ΠΑΡΑΚΡΑΤΟΣ. «Ο ρόλος της Ελληνίδας στην Επανάσταση του 1821», 2η Συνεδρία: “Η θέση της Ελληνίδας κατά την περίοδο της Τουρκοκρατίας”. Διοργάνωση: Σύνδεσμος Ελληνίδων Επιστημόνων (ΣΕΕ).  Copy at http://www.tinyurl.com/yj4f6yx5  Publisher's Version    Abstract  polyethnic.multicultural_slavery_system-converted.pdf   Δυτικές περιηγήτριες που επισκέφτηκαν διάφορες περιοχές της Οθωμανικής Αυτοκρατορίας που κατοικούνταν από Έλληνες τον 17ο, 18ο και 19ο αιώνα αποτύπωσαν τις εντυπώσεις που σχημάτισαν για τις Ελληνίδες εκείνης της εποχής. «Αν κάθε Τούρκος πασάς … Πηγή: Ελληνισμός, Υποδούλωση, Τρομοκρατία και Δουλεία: Αφηγήσεις Δυτικών Περιηγητριών   Πηγή: Από το σύγγραμμα/ βιβλίο της Ειρήνης Καμπερίδου (2012/2014). Επιτέλους αναπνέω ελεύθερη! Γυναικείες Μαρτυρίες - Γυναίκες θαμμένες ζωντανές στον θεσμό της διαφθοράς και της ίντριγκας. ΕΚΔΟΣΕΙΣ "ΤΕΛΕΘΡΙΟΝ", Εκδοτικός Όμιλος ΙΩΝ. Έκδοση 1η 2012. on_female_accounts_by_mary_bossi.pdf

Context. Black-hole X-ray binaries (BHXRBs) in the hard and hard-intermediate spectral (and temporal) states exhibit in their power spectra characteristic frequencies called type-C quasi-periodic oscillations (QPOs). Various models that can explain them with various degrees of success have been proposed, but a definitive answer is still missing. Aims: The hot Comptonizing corona interacting with the cold accretion disk, both of which are central in understanding BHXRBs, is essentially a dynamical system. Our aim is to investigate if the radiative coupling between the two components can produce QPOs. Methods: We write and solve the time-dependent equations that describe energy conservation in the system corona - accretion disk. We examine both constant and variable mass accretion rates. By necessity, in this first investigation we use a simple model, but it contains all the essential ingredients. Results: For a constant mass accretion rate and certain justifiable conditions, the dynamic corona - disk system exhibits oscillations, which die out after a few cycles. The characteristic frequencies of these oscillations are similar to the ones observed in the power spectra of BHXRBs. For most parameters, the natural frequencies persist even in the case of variable accretion rates. Conclusions: We argue that type-C QPOs in BHXRBs could, in principle, arise from the interaction of the hot Comptonizing corona with the much colder accretion disk. If this picture is correct, it has immediate implications for other systems that contain the above constituents, such as active galactic nuclei.

We report on Neutron Star Interior Composition Explorer (NICER), Nuclear Spectroscopic Telescope Array (NuSTAR) and Fermi Gamma-ray Burst Monitor (GBM) observations of the Be-X-ray binary pulsar 1A 0535+262 performed during its giant Type II outburst in 2020, which peaked at a 15-50 keV flux of ~12 Crab. From the Fermi GBM, NICER and NuSTAR measurements, we find the neutron star rotation period decreases from 103.622±0.004 s to 103.24±0.02 s, suggesting that the neutron star rapidly spins-up as the outburst progressed. The NICER and NuSTAR observations, which monitor the evolution of the spectral shape, show the 1-79 keV luminosity peaks at ~1.4 × 1038 erg s-1. This is clearly above ~6.3 × 1037 erg s-1, which is expected around the critical luminosity. We find that the pulse profiles in each observation show a strong energy dependence as well as a strong dependence on luminosity. Emission lines from Fe Kα, Fe XXV Kα and Fe XXVI Kα are observed in the joint NICER and NuSTAR spectra. The line strengths are correlated with the 7.2-10 keV unabsorbed continuum flux. The Fe fluorescent emission lines show no evidence of pulsations, which may suggest that the size of the Fe fluorescent emission region is larger than the Alfvén radius. Although the measured 1-79 keV luminosities are clearly in the supercritical accretion regime, we find that the spectral shape hardens with increasing luminosity. The pulse-phase-averaged NuSTAR data show that the energy of the CRSF around ~45 keV remains virtually unchanged, but the line depth decreases with increasing X-ray flux. This may be a result of photon spawning.

Safety and reliability of gas transmission systems include efficient performance of the gas compressor stations, being indispensable parts of the distribution network. Efficient control of gas compressor stations is an important constraint of the optimization of gas transmission networks. In this paper, the model of a gas compressor station with possible recycle valve (actuator) faults is presented using finite deterministic automata. The desired performance with respect to the safe operation of the process in the case of actuator faults is formulated in the form of regular languages. The goal is surge prevention in the presence of faults. Towards this aim, a modular supervisory control scheme, also providing controller realizability and guaranteeing a nonblocking controlled system, has been developed. The implementation of the controller is accomplished in the form of Ladder Diagrams for PLC use.

The model of the AODV routing protocol, being favorable in several wireless networks (VANET, ZigBee etc.) is presented for a network with parametric number of nodes in the Ramadge Wonham (RW) framework of discrete event systems. Simulation of the automaton of the protocol, for a given four-node network, is provided. For a generic network consisting of n nodes, the goal is to introduce a first simple hierarchy of the requests of the nodes and the routing paths. To this end, a specification is introduced to express the desired hierarchy. The specification of the hierarchy is presented in the form of a simple rule. The rule is translated to a regular language. A supervisor automaton is designed to realize the desired regular language. The nonblocking property of the request flow between the nodes of the network and the satisfactory marked behavior of the controlled automaton are proved. To illustrate the effectiveness of the present control scheme, a four-node network simulation of the controlled automaton of the protocol is provided.

AIMS: Depression and atherosclerotic cardiovascular disease (ASCVD) are commonly clustered in affected patients. Endothelial dysfunction is an early marker of ASCVD while also reported in patients with depression. Emerging evidence suggests that selective serotonin receptor inhibitors (SSRIs) may improve endothelial function. However, clinical studies assessing flow-mediated dilation (FMD), the gold-standard method to evaluate conduit artery endothelial function, in response to SSRIs treatment included limited number of patients and did not provide consistent results. In the present study we aim to evaluate the effect of SSRIs treatment on endothelial function assessed by longitudinal changes in FMD. METHODS AND RESULTS: We performed a systematic review to retrieve and subsequently meta-analyze eligible studies in patients with depression who received SSRIs and had available measurements of FMD change before and after treatment. In 5 studies and 323 individuals in total, SSRIs were associated with increased FMD at the end of follow-up compared to baseline measurement (pooled mean change 1.97 %, 95 % CI 0.17, 3.77, P = 0.032, I(2) = 87.4 %). These results did not substantially change when analysis was restricted to patients with history of atherosclerotic cardiovascular disease (ASCVD). Similarly, FMD changes were higher in individuals receiving SSRIs compared to not-treated subjects (pooled mean difference 2.5 %. 95 % CI 0.7, 4.2, P < 0.001, I(2) = 82.7 %). LIMITATIONS: Substantial heterogeneity regarding with respect to follow-up duration, demographics, and SSRIs agents. CONCLUSION: SSRIs significantly improve FMD, the gold-standard marker of endothelial function. Further investigation is warranted for the role of FMD as a possible therapeutic biomarker in patients with depression and established or subclinical ASCVD. PROSPERO REGISTRATION: CRD42021252241.

The combination of two imaging modalities in a single agent has received increasing attention during the last few years, since its synergistic action guarantees both accurate and timely diagnosis. For this reason, dual-modality contrast agents (DMCAs), such as radiolabeled iron oxide (namely Fe3O4) nanoparticles, constitute a powerful tool in diagnostic applications. In this respect, here we focus on the synthesis of a potential single photon emission computed tomography/magnetic resonance imaging (SPECT/MRI) DMCA, which consists of Fe3O4 nanoparticles, surface functionalized with 2,3-dicarboxypropane-1,1-diphosphonic acid (DPD) and radiolabeled with Tc-99m, [Tc-99m]Tc-DPD-Fe3O4. The in vitro stability results showed that this DMCA is highly stable after 24 h of incubation in phosphate buffer saline (similar to 92.3% intact), while it is adequately stable after 24 h of incubation with human serum (similar to 67.3% intact). Subsequently, [Tc-99m]Tc-DPD-Fe3O4 DMCA was evaluated in vivo in mice models through standard biodistribution studies, MR imaging and gamma-camera imaging. All techniques provided consistent results, clearly evidencing noticeable liver uptake. Our work documents that [Tc-99m]Tc-DPD-Fe3O4 has all the necessary characteristics to be a potential DMCA.

ABSTRACT: The aim of the presentation is to discuss the findings of a series of research projects that we have been carried out with various groups of students in the University of Athens and concern the teaching of biology by means of evolution through natural selection (THES). In the article it is discussed the conclusions after teaching a biology course based on evolution as the unifying theory, while at the same time more general issues are raised: Is it, for example, a realistic goal to teach biology by means of this kind of teaching? Secondly, what is the usefulness of such a perspective. Which was studied by quantitative and qualitative studies on the conceptual ecology (CE) of the evolution of Greek students. The latter showed the value of this kind of approach in the acceptance and understanding of the THES, as part of students’ CI. Thirdly, ccomparative studies with beginners and advanced students in terms of evolution education showed, that, merely teaching evolution within a course, even if the latter is based on the THES, it is not enough to make someone in-depth connoisseur. It seems that to be acquainted with it to more depth the learners need to go through two stages: in the first, they may move from the stage of owing Aristotelian views of the issue, i.e., from typology, to the early “Darwinian” ones. And they need to go through a second one, where via, in-depth educational training, they might move to the next, namely, the population view of thinking.

Glucocorticoids are important for proper organ maturation1. Increased exposure to these hormones during pregnancy, as a result of commonly prescribed synthetic glucocorticoids such as dexamethasone in preterm births2, has been associated with lasting effects on the offspring, including on neurodevelopment and neuropsychiatric disease risk3. While the consequences of glucocorticoid excess in term and especially adult brain have been extensively studied, mainly in rodents4, studies on their effects during early human cortical development are absent. Here we use human cerebral organoids and mice to study cell-type specific effects of glucocorticoids on neurogenic processes. We show that glucocorticoid administration during neurogenesis alters the cellular architecture of the developing cortex by increasing a specific type of gyrencephalic species-enriched basal progenitors that co-express PAX6 and EOMES. This effect is mediated via the glucocorticoid-responsive transcription factor ZBTB16 as shown with overexpression, genetic knock-down and reporter assays experiments in organoids and embryonic mouse models and leads to increased production of deep-layer neurons. A phenome-wide mendelian randomization analysis of a genetic intronic enhancer variant that moderates glucocorticoid-induced ZBTB16 levels, as shown with enhancer assays and enhancer-editing in organoids, reveals potential causal relationships with increased educational attainment as well as neuroimaging phenotypes in adults. In this study we provide a cellular and molecular pathway for the effects of glucocorticoids on human neurogenesis that potentially explains postnatal phenotypes and may be used to refine treatment guidelines.

Cyclobutadienyl complexes of the f-elements are a relatively new yet poorly understood class of sandwich and half-sandwich organometallic compounds. We now describe cyclobutadienyl transfer reactions of the magnesium reagent [(η4-Cb'''')Mg(THF)3] (1), where Cb'''' is tetrakis(trimethylsilyl)cyclobutadienyl, toward thorium(IV) and uranium(IV) tetrachlorides. The 1:1 stoichiometric reactions between 1 and AnCl4proceed with intact transfer of Cb'''' to give the half-sandwich complexes [(η4-Cb'''')AnCl(μ-Cl)3Mg(THF)3] (An = Th, 2; An = U, 3). Using a 2:1 reaction stoichiometry produces [Mg2Cl3(THF)6][(η4-Cb'''')An(η3-C4H(SiMe3)3-κ-(CH2SiMe2)(Cl)] (An = Th, [Mg2Cl3(THF)6][4]; An = U [Mg2Cl3(THF)6][5]), in which one Cb'''' ligand has undergone cyclometalation of a trimethylsilyl group, resulting in the formation of an An-C σ-bond, protonation of the four-membered ring, and an η3-allylic interaction with the actinide. Complex solution-phase dynamics are observed with multinuclear nuclear magnetic resonance spectroscopy for both sandwich complexes. A computational analysis of the reaction mechanism leading to the formation of 4 and 5 indicates that the cyclobutadienyl ligands undergo C-H activation across the actinide center. copy; 2022 American Chemical Society.

Context. The Magellanic Clouds host a large population of high-mass X-ray binary (HMXB) systems, and although the Large Magellanic Cloud (LMC) is an order of magnitude more massive than the Small Magellanic Cloud, there are significantly fewer known HMXBs in the former. Aims: We conducted a search for new HMXBs in XMM-Newton observations that were performed with the aim of investigating supernova remnant candidates in the supergiant shells LMC5 and LMC7. The three observed fields are located in regions that have not been widely explored in the X-ray band. Methods: We analysed the XMM-Newton data to look for sources with hard X-ray spectrum and their counterparts with optical colours and brightness values that are typical of HMXBs. Results: We report the discovery of three new Be/X-ray binaries, two of them showing pulsations in their X-ray flux. With a luminosity of 6.5 × 1034 erg s−1, we see that XMMU J045315.1−693242 in LMC7 was relatively X-ray faint. The long-term OGLE I-band light curve of the V = 15.5 mag counterpart suggests a 49.6 day or 24.8 day orbital period for the binary system. Then, XMMU J045736.9−692727, which is also located in LMC7, was brighter, with a luminosity of 5.6 × 1035 erg s−1 and hard spectrum with a power-law photon index of 0.63. The X-ray flux revealed clear pulsations with a period of 317.7 s. We obtained optical high resolution spectra from the V = 14.2 mag counterpart using the SALT-HRS spectrograph. Hα and Hβ were observed in emission with complex line profiles and equivalent widths of −8.0 Å and −1.3 Å, respectively. The I-band light curve obtained from OGLE shows a series of four strong outbursts followed by a sudden drop in brightness by more than 1 mag within 73-165 days and a recovery to the level from before the outbursts. RX J0524.2−6620, previously classified as X-ray binary candidate, is located at the eastern part of LMC5. We report the discovery of 360.7 s pulsations. During the XMM-Newton observation the luminosity was at ∼4 × 1035 erg s−1 and the source showed a hard spectrum with a power-law photon index of 0.78. The Hα emission line profile obtained from SALT-HRS is characterised by two broad peaks with a separation corresponding to ∼178 km s−1, along with an equivalent width of −4.2 Å. The long-term OGLE I-band light curve of the V = 14.9 mag counterpart reveals a quasi-periodic flaring activity while the colour evolution during the flares follows a hysteresis loop with redder colour during the rise. Based on the modelling the Hα line profiles measured from XMMU J045736.9−692727 and RX J0524.2−6620, we derived constraints on the size of the Be disks. Conclusions: Our discovery of two pulsars among three new Be/X-ray binaries increases the number of known HMXB pulsars in the LMC to 25.

Heterostructured WO3/TiO2 photonic crystal films in the form of three-dimensional macroporous inverse opals were developed by single-step, three-phase co-assembly of colloidal templates with water soluble precursors enabling simultaneous growth of both metal oxides into a firmly interconnected periodic pore framework whose skeletal walls consisted of uniformly distributed nanoscale type II WO3-TiO2 heterojunctions. A marked size- and composition-dependence of the binary WO3/TiO2 inverse opal properties was evidenced by controlling the W/Ti molar ratio and macropore diameter that allowed Fermi level and photonic band gap engineering according to optical and photoelectron spectroscopies supplemented by electrochemical measurements. Compositional tuning along with the reduction of WO3 nanocrystallite size and the concomitant W5+ defect growth with increasing TiO2 phase content were explored for the optimization of photocurrent generation by WO3/TiO2 inverse opal photoanodes combining reduced charge carrier recombination and optimal slow light trapping. One step co-assembly of mixed metal oxides is concluded as a promising route for the development of heterostructured inverse opal networks with tailored electronic properties and improved solar light harvesting for photo-induced applications.

It is widely acclaimed that the Markowitz mean–variance portfolio selection is a very important investment strategy. One approach to solving the static mean–variance portfolio selection (MVPS) problem is based on the usage of quadratic programming (QP) methods. In this article, we define and study the time-varying mean–variance portfolio selection (TV-MVPS) problem both in the cases of a fixed target portfolio’s expected return and for all possible portfolio’s expected returns as a time-varying quadratic programming (TVQP) problem. The TV-MVPS also comprises the properties of a moving average. These properties make the TV-MVPS an even greater analysis tool suitable to evaluate investments and identify trading opportunities across a continuous-time period. Using an originally developed linear-variational-inequality primal–dual neural network (LVI-PDNN), we also provide an online solution to the static QP problem. To the best of our knowledge, this is an innovative approach that incorporates robust neural network techniques to provide an online, thus more realistic, solution to the TV-MVPS problem. In this way, we present an online solution to a time-varying financial problem while eliminating static method limitations. It has been shown that when applied simultaneously to TVQP problems subject to equality, inequality and boundary constraints, the LVI-PDNN approaches the theoretical solution. Our approach is also verified by numerical experiments and computer simulations as an excellent alternative to conventional MATLAB methods.

Measuring a pulsar's rotational evolution is crucial to understanding the nature of the pulsar. Here, we provide updated timing models for the rotational evolution of six pulsars, five of which are rotation phase-connected using primarily NICER X-ray data. For the newly discovered fast energetic young pulsar, PSR J0058-7218, we increase the baseline of its timing model from 1.4 days to 8 months and not only measure more precisely its spin-down rate $\dot{\nu }=(-6.2324\pm 0.0001)\times {10}^{-11}\,\mathrm{Hz}\,{{\rm{s}}}^{-1}$ but also for the first time the second time derivative of its spin rate $\ddot{\nu }=(4.2\pm 0.2)\times {10}^{-21}\,\mathrm{Hz}\,{{\rm{s}}}^{-2}$ . For the fastest and most energetic young pulsar, PSR J0537-6910 (with a 16 ms spin period), we detect four more glitches, for a total of 15 glitches over 4.5 yr of NICER monitoring, and show that its spin-down behavior continues to set this pulsar apart from all others, including a long-term braking index n = -1.234 ± 0.009 and interglitch braking indices that asymptote to ≲7 for long times after a glitch. For PSR J1101-6101, we measure a much more accurate spin-down rate that agrees with a previous value measured without phase connection. For PSR J1412+7922 (also known as Calvera), we extend the baseline of its timing model from our previous 1 yr model to 4.4 yr, and for PSR J1849-0001, we extend the baseline from 1.5 to 4.7 yr. We also present a long-term timing model of the energetic pulsar PSR J1813-1749, by fitting previous radio and X-ray spin frequencies from 2009-2019 and new ones measured here using 2018 NuSTAR and 2021 Chandra data.

Τhe incumbent technology for bringing light to the nanoscale, the near-field scanning optical microscope, has notoriously small throughput efficiencies of the order of 104 −105, or less. We report on a broadband, topological, unidirectionally guiding structure, not requiring adiabatic tapering and, in principle, enabling near-perfect (∼100%) optical transmission through an unstructured single arbitrarily subdiffraction slit at its end. Specifically, for a slit width of just λeff/72 (λ0/138) the attained normalized transmission coefficient reaches a value of 1.52, while for a unidirectional-only (nontopological) device the normalized transmission through a λeff/21 (∼λ0/107) slit reaches 1.14; both limited only by inherent material losses, and with zero reflection from the slit. The associated, under ideal (ultralow-loss) conditions, near-perfect optical extraordinary transmission has implications, among diverse areas in wave physics and engineering, for high-efficiency, maximum-throughput nanoscopes and heat-assisted magnetic recording devices.

One of the most often used approaches for approximating various matrix equation problems is the hyperpower family of iterative methods with arbitrary convergence order, whereas the zeroing neural network (ZNN) is a type of neural dynamics intended for handling time-varying problems. A family of ZNN models that correlate with the hyperpower iterative methods is defined on the basis of the analogy that was discovered. These models, known as higher-order ZNN models (HOZNN), can be used to find real symmetric solutions of time-varying algebraic Riccati equations. Furthermore, a noise-handling HOZNN (NHOZNN) class of dynamical systems is introduced. The traditional ZNN and HOZNN dynamic flows are compared theoretically and numerically.

An increasing number of solute transporters have been shown to function with the so-called sliding-elevator mechanism. Despite structural and functional differences, all elevator-type transporters use a common mechanism of substrate translocation via reversible movements of a mobile core domain (the elevator) hosting the substrate binding site along a rigid scaffold domain stably anchored in the plasma membrane via homodimerization. One of the best-studied elevator transporters is the UapA uric acid-xanthine/H+ symporter of the filamentous fungus Aspergillus nidulans. Here, we present a genetic analysis for deciphering the role of transmembrane segments (TMS) 5 and 12 in UapA transport function. We show that specific residues in both TMS5 and TMS12 control, negatively or positively, the dynamics of transport, but also substrate binding affinity and specificity. More specifically, mutations in TMS5 can lead not only to increased rate of transport but also to an inactive transporter due to high-affinity substrate-trapping, whereas mutations in TMS12 lead to apparently uncontrolled sliding and broadened specificity, leading in specific cases to UapA-mediated purine toxicity. Our findings shed new light on how elevator transporters function and how this knowledge can be applied to genetically modify their transport characteristics.

The regular reappearance of coronavirus (CoV) outbreaks over the past 20 years has caused significant health consequences and financial burdens worldwide. The most recent and still ongoing novel CoV pandemic, caused by Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) has brought a range of devastating consequences. Due to the exceptionally fast development of vaccines, the mortality rate of the virus has been curbed to a significant extent. However, the limitations of vaccination efficiency and applicability, coupled with the still high infection rate, emphasise the urgent need for discovering safe and effective antivirals against SARS-CoV-2 by suppressing its replication or attenuating its virulence. Non-structural protein 1 (nsp1), a unique viral and conserved leader protein, is a crucial virulence factor for causing host mRNA degradation, suppressing interferon (IFN) expression and host antiviral signalling pathways. In view of the essential role of nsp1 in the CoV life cycle, it is regarded as an exploitable target for antiviral drug discovery. Here, we report a variety of fragment hits against the N-terminal domain of SARS-CoV-2 nsp1 identified by fragment-based screening via X-ray crystallography. We also determined the structure of nsp1 at atomic resolution (0.99 A). Binding affinities of hits against nsp1 and potential stabilisation were determined by orthogonal biophysical assays such as microscale thermophoresis and thermal shift assays. We identified two ligand-binding sites on nsp1, one deep and one shallow pocket, which are not conserved between the three medically relevant SARS, SARS-CoV-2 and MERS coronaviruses. Our study provides an excellent starting point for the development of more potent nsp1-targeting inhibitors and functional studies on SARS-CoV-2 nsp1.

Blazars are a class of active galactic nuclei that host relativistic jets oriented close to the observer's line of sight. Blazars have very complex variability properties. Flares, namely flux variations around the mean value with a well-defined shape and duration, are one of the identifying properties of the blazar phenomenon. Blazars are known to exhibit multiwavelength flares, but also "orphan" flares, namely flux changes that appear only in a specific energy range. Various models, sometimes at odds with each other, have been proposed to explain specific flares even for a single source, and cannot be synthesized into a coherent picture. In this paper, we propose a unified model for explaining orphan and multiwavelength flares from blazars in a common framework. We assume that the blazar emission during a flare consists of two components: (i) a quasistable component that arises from the superposition of numerous but comparatively weak dissipation zones along the jet, forming the background (low-state) emission of the blazar, and (ii) a transient component, which is responsible for the sudden enhancement of the blazar flux, forming at a random distance along the jet by a strong energy dissipation event. Whether a multiwavelength or orphan flare is emitted depends on the distance from the base of the jet where the dissipation occurs. Generally speaking, if the dissipation occurs at a small/large distance from the supermassive black hole, the inverse Compton/synchrotron radiation dominates and an orphan γ -ray/optical flare tends to appear. On the other hand, we may expect a multiwavelength flare if the dissipation occurs at an intermediate distance. We show that the model can successfully describe the spectral energy distribution of different flares from the flat spectrum radio quasar 3C 279 and the BL Lacertae object PKS 2155-304.

In the context of infinite-horizon optimal control problems, the algebraic Riccati equations (ARE) arise when the stability of linear time-varying (LTV) systems is investigated. Using the zeroing neural network (ZNN) approach to solve the time-varying eigendecomposition-based ARE (TVE-ARE) problem, the ZNN model (ZNNTVE-ARE) for solving the TVE-ARE problem is introduced as a result of this research. Since the eigendecomposition approach is employed, the ZNNTVE-ARE model is designed to produce only the unique nonnegative definite solution of the time-varying ARE (TV-ARE) problem. It is worth mentioning that this model follows the principles of the ZNN method, which converges exponentially with time to a theoretical time-varying solution. The ZNNTVE-ARE model can also produce the eigenvector solution of the continuous-time Lyapunov equation (CLE) since the Lyapunov equation is a particular case of ARE. Moreover, this paper introduces a hybrid ZNN model for stabilizing LTV systems in which the ZNNTVE-ARE model is employed to solve the continuous-time ARE (CARE) related to the optimal control law. Experiments show that the ZNNTVE-ARE and HFTZNN-LTVSS models are both effective, and that the HFTZNN-LTVSS model always provides slightly better asymptotic stability than the models from which it is derived.

Cell-Free (CF) Massive MIMO (mMIMO) is a technology which can potentially augment not only the deployment of 5G, but also the deployment of "beyond 5G'' (B5G) wireless networks. The basic idea behind this “user-centric” arrangement is that many spatially dispersed access points (APs) coherently serve all nearby devices without being confined by cell boundaries. However, the cost for rolling out such systems, at a macro-level, may be significant. Radio stripes form a promising intermediate solution, which offers the potential of scalability at a reduced price. This paper investigates the uplink scenario of a CF massive MIMO (mMIMO) system, implemented with a limited-capacity radio stripe, which integrates a novel AP arrangement that fully exploits macro-diversity benefits. We also analyze a heuristic compare-and-forward (CnF) strategy, which, by comparing normalized minimum mean square error (N-MMSE) soft estimates, enables optimal dynamic cooperation clustering. Aiming at maximizing the spectral efficiency (SE) of a high percentage of users, we ensure that, under finite capacity constraints, our solution can guarantee better performance than existing radio stripe architectures when size of the system scales.

Coastal areas constitute a very dynamic environment, balancing between numerous natural and anthropogenic processes liable to sometimes hazardous geomorphic phenomena. Especially in tectonically active coastal regions and areas of high economic value, slope failures can have significant impacts and therefore need careful and detailed examination. This work uses Unmanned Aerial System (UAS)-aided photogrammetry and Terrestrial Laser Scanning (TLS) in tectonically active segments of the coastal zone of the Ionian Islands in Greece, to explore how their capabilities can help to improve our understanding of the structural integrity of the slopes. Results show that the two approaches are able to extract large numbers of discontinuity facets, in a more practical, rapid and safe way than conventional methods of rock slope stability analysis extending to unreachable yet important parts of the slope. Through this holistic record of the structural condition of the slope the two applications allow the identification of segments that are more prone to instability and failure. In this way, they improve our understanding of the prioritization of interventions aiming to enhance the prevention of slope failures, mitigating the associated risk and improving local development in these high-value locations.

Coastal areas constitute a very dynamic environment, balancing between numerous natural and anthropogenic processes liable to sometimes hazardous geomorphic phenomena. Especially in tectonically active coastal regions and areas of high economic value, slope failures can have significant impacts and therefore need careful and detailed examination. This work uses Unmanned Aerial System (UAS)-aided photogrammetry and Terrestrial Laser Scanning (TLS) in tectonically active segments of the coastal zone of the Ionian Islands in Greece, to explore how their capabilities can help to improve our understanding of the structural integrity of the slopes. Results show that the two approaches are able to extract large numbers of discontinuity facets, in a more practical, rapid and safe way than conventional methods of rock slope stability analysis extending to unreachable yet important parts of the slope. Through this holistic record of the structural condition of the slope the two applications allow the identification of segments that are more prone to instability and failure. In this way, they improve our understanding of the prioritization of interventions aiming to enhance the prevention of slope failures, mitigating the associated risk and improving local development in these high-value locations.

Precision Agriculture (PA) tends to become a contemporary trend nowadays, as agriculture constitutes a really big part of economy with great social impact around the world. Among the advantages of using Precision Agriculture (PA) are the decrease in cost, time and human resources. Aerial remote sensing data processing and interpretation is a modern way of recognizing and classifying vegetation, within high resolution and precision imagery outputs, which can be utilized for further image processing and classification such as in Normalized difference vegetation index NDVI, Modified Chlorophyll Absorption Ratio Index, MCARI, and Modified Soil-Adjusted Vegetation Index, MSAVI. The application of such thematic products may lead to the best decisions for the most prominent ways of interference during the entire cultivation process. Using unmanned aerial systems (UAS), onboard sensors and GNSS for better precision and of course high residual multispectral images with several bands which can give precious information after being post processed, the data acquisition phase has become relatively easy and with the lowest cost, not to mention the frequent update upon request. In this work, we present a multispectral flying platform. The proposed solution is based on a commercial Quantum Trinity F90+ drone equipped with a combination of a high-resolution RGB camera UMC R10C and a multispectral MicaSense RedEdge-MX camera.

In volleyball outside hitters have wide participation in the offensive game. This study aims to analyze the variables that predict attack effectiveness in top-level volleyball depending on gender. ...

PURPOSE: To evaluate the association between serum vitamin B12/folate and retinal vein occlusion (RVO). METHODS: A comprehensive search of the PubMed database was performed, which identified 271 abstracts to be screened. Ten studies met our inclusion criteria and a meta-analysis of these comparative case-control studies was performed on the mean +/- standard deviation serum vitamin B12 and folate levels, without language restrictions. Nine studies with 720 patients with RVO and 613 controls were included in the meta-analysis for vitamin B12, and 10 studies with 784 patients with RVO and 677 controls in the meta-analysis for folate. RESULTS: There was no statistically significant difference between patients with RVO and controls in serum vitamin B12 levels (mean difference: - 40.25 pg/mL, p = 0.28), either central RVO (mean difference: - 18.24 pg/mL, p = 0.71) or branch RVO (mean difference: - 23.56 pg/mL, p = 0.48). On the contrary, the plasma folate level was significantly lower in RVO patients than in controls (mean difference: - 1.34 ng/mL, p = 0.001), as well as in patients with CRVO compared to controls (mean difference: - 1.48 ng/mL, p = 0.006), but not in BRVO patients (mean difference: - 0.72 ng/mL, p = 0.11). CONCLUSIONS: RVO is associated with low serum folate levels, but not with serum vitamin B12 levels

Global exposure of children to sexual abuse is widespread. Disclosure may be extremely upsetting for both families and medical professionals. This review provides medical practitioners with practical tips for a stepwise approach of the child who discloses sexual abuse. Having secured a private examination room, the physician should approach the child and caregivers separately to determine the level of concern for abuse and the urgency of the situation. The medical evaluation is based on the information gathered, including a complete physical examination, inspection of the genitalia, collection of forensic evidence, and testing for sexually transmitted diseases. On a case-by-case basis, the need for surgical intervention, prophylactic treatment, and immunization is discussed. Finally, important questions for the medical team to address are outlined with the goal of supporting the child and his/her family and ultimately stopping the abuse.

Aims: We conducted a spectral and temporal analysis of X-ray data from the Be X-ray binary pulsar SXP 15.6 located in the Small Magellanic Cloud based on NuSTAR, NICER, and Swift observations during the 2021 outburst. Methods: We present the broadband X-ray spectra of the system based on simultaneous NuSTAR and NICER observations for the first time. Moreover, we used monitoring data to study the spectral and temporal properties of the system during the outburst. Results: Comparison of the evolution of the 2021 outburst with archival data reveals a consistent pattern of variability, with multiple peaks occurring at time intervals similar to the orbital period of the system (∼36 d). Our spectral analysis indicates that most of the energy is released at high energies above 10 keV, while we found no cyclotron absorption line in the spectrum. Analysing of the spectral evolution during the outburst, we find that the spectrum is softer when brighter, which in turn reveals that the system is probably in the super-critical regime in which the accretion column is formed. This places an upper limit on the magnetic field of the system of about 7 × 1011 G. The spin-evolution of the neutron star (NS) during the outburst is consistent with an NS with a low magnetic field (∼5 × 1011 G), while there is evident orbital modulation that we modelled, and we derived the orbital parameters. We found the orbit to have a moderate eccentricity of ∼0.3. Our estimates of the magnetic field are consistent with the lack of an electron cyclotron resonance scattering feature in the broadband X-ray spectrum.

This research introduces three novel zeroing neural network (ZNN) models for addressing the time-varying Yang–Baxter-like matrix equation (TV-YBLME) with arbitrary (regular or singular) real time-varying (TV) input matrices in continuous time. One ZNN dynamic utilizes error matrices directly arising from the equation involved in the TV-YBLME. Moreover, two ZNN models are proposed using basic properties of the YBLME, such as the splitting of the YBLME and sufficient conditions for a matrix to solve the YBLME. The Tikhonov regularization principle enables addressing the TV-YBLME with an arbitrary input real TV matrix. Numerical experiments, including nonsingular and singular TV input matrices, show that the suggested models deal effectively with the TV-YBLME.

Many researchers have investigated the time-varying (TV) matrix pseudoinverse problem in recent years, for its importance in addressing TV problems in science and engineering. In this paper, the problem of calculating the inverse or pseudoinverse of an arbitrary TV real matrix is considered and addressed using the singular value decomposition (SVD) and the zeroing neural network (ZNN) approaches. Since SVD is frequently used to compute the inverse or pseudoinverse of a matrix, this research proposes a new ZNN model based on the SVD method as well as the technique of Tikhonov regularization, for solving the problem in continuous time. Numerical experiments, involving the pseudoinversion of square, rectangular, singular, and nonsingular input matrices, indicate that the proposed models are effective for solving the problem of the inversion or pseudoinversion of time varying matrices.

Nikolaos-Ioannis Koskinas wirft in seinem Beitrag einen komparatistischen Blick auf ein griechisches und ein deutschsprachiges Theaterstück – Fräulein Unglück (Δεσποινίς Δυστυχία, 2018) von Tsimaras Tzanatos und Die Verfassung der Strände (2012) von dem österreichischen Dramatiker Stephan Lack. Beide Werke stellen den maritimen Raum ins Zentrum und setzen sich kritisch mit anthropogenen Umweltveränderungen aus-einander. Während Lack bei der Behandlung der Problematik Mensch-Umwelt eine anthropozentrische Perspektive einnimmt, wird das Meer in dem Stück von Tzanatos zum eigentlichen Protagonisten und die menschlichen Akteure treten zugunsten einer dezentrierten Perspektive eher in den Hintergrund, die die Vielschichtigkeit der weit über den Menschen hinausreichenden Natur widerspiegeln soll.

During the 2021-2022 school year, the innovative lesson “Skills Labs” was introduced in the Greek school curriculum with the aim to enhance students’ everyday skills, life skills as well as technology and science skills. The principal aim of this research was to examine teachers’ familiarity on the suggested teaching methods which are the prerequisites for the effective implementation of the “Skills Labs”. Participants were 110 teachers of various specialties who completed a questionnaire assessing their experiences and views regarding the “Skills Labs”. Results showed that teachers are familiar with alternative teaching methods such as the Experiential, Cooperative and Personalized methods. Most of the teachers, though, did not take full advantage of these teaching methods in class. This may reflect the fact that they lack adequate in-service training as well as teaching experience. Moreover, teachers’ teaching experience and level of education were significantly related to their teaching methods. It was also found that the effective implementation of the “Skills Labs”, according to teachers’ views, depends on various factors, such as students’ readiness, adequate teaching time, and classroom infrastructure. Finally, based on the results of this study, suggestions for educational policy are made.

Στόχος της παρούσας εργασίας είναι, μέσω της ανάλυσης βιογραφιών ζωής εξαρτημένων ατόμων, να διερευνηθεί η σχέση ανάμεσα στα τραυματικά γεγονότα ζωής και τα συναισθήματα που τα συνοδεύουν με την έναρξη της χρήσης ουσιών και την πρόωρη εγκατάλειψη του σχολείου. Η ανάλυση βιογραφιών ζωής ατόμων που εισάγονται σε προγράμματα απεξάρτησης του ΚΕΘΕΑ αξιοποιείται προκειμένου να διερευνηθούν οι ερμηνείες και το νόημα που τα ίδια αποδίδουν στις εμπειρίες τους αλλά και να γίνει κατανοητός ο τρόπος κατασκευής ιστοριών ζωής από τη σκοπιά του παρόντος. Μέσα από την ανάλυση δέκα βιογραφιών ζωής τις οποίες καλούνται να συγγράψουν όλα τα άτομα που συμμετέχουν σε θεραπευτική κοινότητα απεξάρτησης, αναζητά την ερμηνεία που τα ίδια τα άτομα δίνουν για τη σχέση ανάμεσα στα τραυματικά γεγονότα ζωής και στην έναρξη της χρήσης ουσιών, τη σχολική αποτυχία και την πρόωρη διακοπή του σχολείου. Με τη μέθοδο της ανάλυσης περιεχομένου προκύπτει ότι σε κάθε αναπτυξιακή φάση αναδύονται συγκεκριμένοι παράγοντες που συνδυάζονται με την πρόωρη εγκατάλειψη του σχολείου και την έναρξη της χρήσης ουσιών και που αφορούν κυρίως δυσμενείς εμπειρίες ζωής κατά την παιδική ηλικία. Η εργασία προτείνει την εφαρμογή προγραμμάτων διά βίου μάθησης και μη τυπικής εκπαίδευσης στο σύνολο της σχολικής κοινότητας για την πρόληψη της σχολικής διαρροής και της χρήσης ουσιών.

Σκοπός της παρούσας ερευνητικής μελέτης είναι η διερεύνηση των δυσμενών εμπειριών ζωής κατά την παιδική ηλικία και η σύνδεση αυτών με την κατάχρηση ουσιών και την έλλειψη στέγης στην ενήλικη ζωή. Συμμετέχοντες στη μελέτη είναι έντεκα άτομα, άντρες και γυναίκες, που παρακολουθούν τα προγράμματα των Μονάδων Υποκατάστασης Βουπρενορφίνης του ΟΚΑΝΑ (ΜΟΘΕ) στη Βόρεια Ελλάδα. Η μεθοδολογία διεξαγωγής της συγκεκριμένης έρευνας βασίζεται στη βιογραφική αφηγηματική προσέγγιση, ένα εργαλείο ποιοτικής έρευνας, που κρίθηκε ως καταλληλότερο για τη σε βάθος μελέτη των δυσμενών εμπειριών ζωής και την αλληλεπίδραση αυτών με την πρόωρη εγκατάλειψη του σχολείου, την κατάχρηση ουσιών και την αστεγία. Η επεξεργασία των βιογραφιών που συγκεντρώθηκαν έδειξε ότι σε όλες τις περιπτώσεις οι δυσμενείς εμπειρίες ζωής και η απώλεια/εναλλαγή στέγης χαρακτήριζε ως κεντρικό βίωμα της παιδικής ηλικίας τις αφηγήσεις όλων των συμμετεχόντων/ουσών και προηγήθηκε της πρόωρης εγκατάλειψης του σχολείου και της εμφάνισης της κατάχρησης ουσιών, η οποία προέκυψε μεταγενέστερα ως μια προσπάθεια ανακούφισης και «αυτοθεραπείας».

Η Ειρήνη Καμπερίδου, Καθηγήτρια Κοινωνιολογίας ΣΕΦΑΑ, ΕΚΠΑ μίλησε  για τη γυναικεία εμπειρία και δράση (women's agency) σε εμπόλεμες ζώνες και συγκρουσιακές συγκυρίες στην ημερίδα που διοργάνωσε το Γενικό Επιτελείο Εθνικής Άμυνας (ΓΕΕΘΑ), Διεύθυνση Υγειονομικού, Τμήμα Υγειονομικής Πολιτικής και Προληπτικής Ιατρικής, υπό τον τίτλο «Διαστάσεις Ψυχικής Υγείας στις Ένοπλες Δυνάμεις». Ανέδειξε τον πρωτοποριακό και καθοριστικό ρόλο των γυναικών (του 19ου αιώνα και των αρχών του 20ου) στην επίλυση επειγόντων και συγκρουσιακών καταστάσεων, την κοινωνική μέριμνα και τη δημόσια υγεία. Η διάλεξη της κας Καμπερίδου ήταν αφιερωμένη στην επέτειο μνήμης των 100 χρόνων από τη Μικρασιατική Καταστροφή (1922-2022).  Η εν λόγω διοργάνωση πραγματοποιήθηκε στο Αμφιθέατρο «Επισμηναγός (ΠΙΤ) Δημήτριος Καμπέρος» του ΓΕΕΘΑ, στο στρατόπεδο Παπάγου, 15  Δεκεμβρίου 2022. Την έναρξη των εργασιών της ημερίδας κήρυξε ο Πτέραρχος Δημήτριος Χατζηγεωργίου, Διευθυντής Υγειονομικού του ΓΕΕΘΑ. Στην εκδήλωση συμμετείχε ο Συνταγματάρχης Παναγιώτης Ποδαρόπουλος, Υποδιευθυντής Υγειονομικού του ΓΕΕΘΑ και η Αντισμήναρχος και ψυχίατρος Στέλλα Νίκα. Λέξεις κλειδιά: Επιτόπιες μαρτυρίες, φύλο, γυναίκα, πόλεμος, εθελοντισμός, επαγγελματισμός, γυναικεία πρωτοβουλία-δράση (women's agency), επιχειρηματικότητα και καινοτομία   --Στο HUB του ΕΚΠΑ https://hub.uoa.gr/conference-on-dimensions-of-mental-health-lecture-by-professor-kaberidou/ --Στην κεντρική ιστοσελίδα του ΕΚΠΑ https://www.uoa.gr/anakoinoseis_kai_ekdiloseis/proboli_anakoinosis/diastaseis_psychikis_ygeias_stis_enoples_dynameis/