Background: Small cell carcinomas (SCC) originate mainly from bronchial tissue. Several extrapulmonary sites of origin have been described, including the genitourinary and gastrointestinal tracts, the ear, nose and throat and lymph nodes. SCC of the lung may be associated with paraneoplastic neurologic syndromes. Case Report: We report an oat cell histological variant of SCC found in the thymus gland of a 53-year-old woman who presented with subacute cerebellar dysfunction. Conclusions: SCC of the thymus gland, which is a rare extrapulmonary site of origin of SCC, accompanied by cerebellar dysfunction, is rarely reported.
Στα τέλη του 19ου αι. σε όλες τις ελληνικές κοινότητες της Αμερικής γεννήθηκε και ένας ερασιτεχνικός θίασος δρώντας εθελοντικώς και προσφέροντας υπηρεσίες δίδοντας ευεργετικές παραστάσεις. Το πρώτο μισό του 20ού αι. η θεατρική κίνηση αυξάνεται ραγδαία. Η εξαπλωμένη θεατρική δραστηριότητα δεν αφήνει ανέπαφη ούτε την μικρότερη ελληνική κοινότητα στην Αμερική. Και η μικρότερη παροικία διέθετε ερασιτεχνικό θεατρικό όμιλο και κάθε αστικό κέντρο διέθετε επαγγελματικό ελληνικό θίασο. Το θέατρο γίνεται για τους μετανάστες οικείος τρόπος έκφρασης. Μετά τη δεκαετία του 1950 διαφαίνεται μια μεταστροφή. Στις θεατρικές ομάδες συμμετέχουν και Έλληνες δεύτερης γενιάς, το ρεπερτόριο παραμένει ελληνικό αλλά η γλώσσα παύει να είναι η ελληνική. Μετά το δεύτερο παγκόσμιο πόλεμο τα έργα των Ελληνοαμερικανών δραματουργών γράφονται κυρίως στην αγγλική. Οι πρώτοι μετανάστες απ’ τη μια αγνοούσαν πλήρως την αγγλική κι απ’ την άλλη απευθύνονταν αυστηρά στο κοινό των Ελλήνων μεταναστών. Οι Έλληνες δεύτερης γενιάς αλλά και εκείνοι, οι οποίοι διασχίζουν τον Ατλαντικό μεταπολεμικά διακατέχονται από την ανάγκη να απεγκλωβιστούν από τα στενά όρια των ελληνικών κοινοτήτων και να αναπτύξουν πιο σύνθετες ανάγκες επικοινωνίας σε ένα διευρυμένο περιβάλλον διατηρώντας όμως συναισθηματικά στοιχεία σε σχέση με την ελληνικότητα, όπως διαφαίνεται στη συγγραφέα Αθηνά Ντάλλα-Ντάμη. Το δεύτερο μισό του 20ου αι. σηματοδοτείται από τον Αδαμάντιο Λεμό, τον George Arkas, τον Yiannis Simonides, ο οποίος το 1979 όταν ήταν ακόμα καθηγητής και πρόεδρος του Drama Department of New York University ίδρυσε το Greek Theater of New York. Αξιοσημείωτη είναι η εμφάνιση του νεοσύστατου θιάσου στο La Mama E.T.C., 74 A East Fourth Street όπου παρουσίασε τα “Theatrika”, ένα φεστιβάλ μουσικής, χορού, ποίησης και θεάτρου στην αγγλική γλώσσα αλλά και στην ελληνική. Παράλληλα με τη δράση των George Arkas και Yannis Simonides, το 1974 ιδρύθηκε το Greek Cultural Center, με σκοπό να προάγει τη μουσική, τους παραδοσιακούς χορούς, το θέατρο σκιών και το θέατρο. Η συστηματική θεατρική δράση ξεκίνησε το 1978. Τα τελευταία τριάντα χρόνια έχει παραστήσει πάνω από 75 έργα. Και ο θίασος έχει επανδρωθεί από νέους Έλληνες επαγγελματίες και κατορθώνει να ανεβάζει έως και τέσσερις παραγωγές ετησίως λαμβάνοντας θερμές κριτικές και στηρίζοντας σθεναρά το νεοελληνικό θέατρο.
The study of particulate matter with diameter less than 1 μm (PM 1) in Athens' atmosphere and their impacts on human health is the goal of this study. PM1 concentrations were recorded by three detectors (light scattering method) at six vital points in high traffic peak roads, during the period 1/10/2006-30/9/2007. The collected PM1 samples concern the same hour of the day, in absence of wind. The spatial distributions of the PM1 concentrations for the warm (April to September) and the cold (October to March) period of the year were achieved by the use of Kriging method. Further to, in order to find out the impacts of PM1 concentrations on health, we analyzed daily admissions for non-fatal arrhythmias to emergency units of the Social Security Institute and a Regional Hospital of Athens. Results demonstrate a significant relationship of PM1 with sinus arrhythmias, which confirms the assumption that PM1 represent one of the main hazards in cardio respiratory syndromes in the most polluted cities of Europe, which confront high traffic problems, due to the enormous number of exhausts emissions.
UapA, a uric acid-xanthine permease of Aspergillus nidulans, has been used as a prototype to study structure-function relationships in the ubiquitous nucleobase-ascorbate transporter (NAT) family. Using novel genetic screens, rational mutational design, chimeric NAT molecules, and extensive transport kinetic analyses, we show that dynamic synergy between three distinct domains, transmembrane segment (TMS)1, the TMS8-9 loop, and TMS12, defines the function and specificity of UapA. The TMS8-9 loop includes four residues absolutely essential for substrate binding and transport (Glu356, Asp388, Gln408, and Asn409), whereas TMS1 and TMS12 seem to control, through steric hindrance or electrostatic repulsion, the differential access of purines to the TMS8-9 domain. Thus, UapA specificity is determined directly by the specific interactions of a given substrate with the TMS8-9 loop and indirectly by interactions of this loop with TMS1 and TMS12. We finally show that intramolecular synergy among UapA domains is highly specific and propose that it forms the basis for the evolution of the unique specificity of UapA for uric acid, a property not present in other NAT members.
We study the possibility of spin injection from Fe into Si(001), using the Schottky barrier at the Fe/Si contact as tunneling barrier. Our calculations are based on density-functional theory for the description of the electronic structure and on a Landauer-Buttiker approach for the current. The current-carrying states correspond to the six conduction-band minima (pockets) of Si, which, when projected on the (001) surface Brillouin zone (SBZ), form five conductance hot spots: one at the SBZ center and four symmetric satellites. The satellites yield a current polarization of about 50%, while the SBZ center can, under very low gate voltage, yield up to almost 100%, showing a zero-gate anomaly. This extremely high polarization is traced back to the symmetry mismatch of the minority-spin Fe wave functions to the conduction-band wave functions of Si at the SBZ center. The tunneling current is determined by the complex band structure of Si in the {[}001] direction, which shows qualitative differences compared to that of direct-gap semiconductors. Depending on the Fermi level position and Schottky barrier thickness, the complex band structure can cause the contribution of the satellites to be orders of magnitude higher or lower than the central contribution. Thus, by appropriate tuning of the interface properties, there is a possibility to cut off the satellite contribution and to reach high injection efficiency. Also, we find that a moderate strain of 0.5% along the {[}001] direction is sufficient to lift the degeneracy of the pockets so that only states at the zone center can carry current.
Violence and Racism in sport under the spotlight Sport federations, academics, politicians, and NGOs alike are sounding the alarm over the increase in violence and racism linked with sport events. In recent years we have seen many manifestations of racial intolerance and violence at football matches, converted into stages for regional and identity conflicts: (1) In Spain, racist right-wing supporters mocked and taunted black players. (2) In Greece, an Albanian fan was stabbed to death by a Greek at a qualifying match for the World Cup. (3) A referee was slashed by a missile at the Champions League match between Roma and Dynamo Kiev. (4) In the Netherlands, Dutch fans threw a smoke bomb into the Portuguese goal and firecrackers on to the pitch, hitting one of the players at the UEFA Cup match between Feyenoord of Rotterdam and Sporting Lisbon of Portugal. (5) German police used clubs and riot gas to arrest 46 fans after a minor regional league match between SSV Ulm of Germany and visiting FC Normannia Gmuend of Switzerland. (6) The violence in Milan, when two bitter rivals, Inter and AC, played in the quarter-finals for the Champions League, the top European club tournament, and (5) riots, such as those in the cities of Leipzig (Germany) and Catania (Italy), are the reason why the EU ministers responsible for sport are now closely studying the issue of sport and violence. Instead of focusing on enjoying sports, teaching youth pro-social attitudes and values through sports, or in reaping physical benefits, and instilling a lifelong involvement in athletics, we have been witnessing a notable increase of violent behaviour in stadiums, dehumanizing racist and xenophobic attitudes, hooliganism, doping, corruption, cheating, wheeling-and-dealing, political interference as well as the influence of big business, the media, sponsors, etc. Has sport lost its fun, and its positive social impact and values? Is it geared exclusively toward winning at all costs, and supporting obsessive competitiveness that leads to violence and racial conflicts?
Violence and Racism in sport under the spotlight Sport federations, academics, politicians, and NGOs alike are sounding the alarm over the increase in violence and racism linked with sport events. In recent years we have seen many manifestations of racial intolerance and violence at football matches, converted into stages for regional and identity conflicts: (1) In Spain, racist right-wing supporters mocked and taunted black players. (2) In Greece, an Albanian fan was stabbed to death by a Greek at a qualifying match for the World Cup. (3) A referee was slashed by a missile at the Champions League match between Roma and Dynamo Kiev. (4) In the Netherlands, Dutch fans threw a smoke bomb into the Portuguese goal and firecrackers on to the pitch, hitting one of the players at the UEFA Cup match between Feyenoord of Rotterdam and Sporting Lisbon of Portugal. (5) German police used clubs and riot gas to arrest 46 fans after a minor regional league match between SSV Ulm of Germany and visiting FC Normannia Gmuend of Switzerland. (6) The violence in Milan, when two bitter rivals, Inter and AC, played in the quarter-finals for the Champions League, the top European club tournament, and (5) riots, such as those in the cities of Leipzig (Germany) and Catania (Italy), are the reason why the EU ministers responsible for sport are now closely studying the issue of sport and violence. Instead of focusing on enjoying sports, teaching youth pro-social attitudes and values through sports, or in reaping physical benefits, and instilling a lifelong involvement in athletics, we have been witnessing a notable increase of violent behaviour in stadiums, dehumanizing racist and xenophobic attitudes, hooliganism, doping, corruption, cheating, wheeling-and-dealing, political interference as well as the influence of big business, the media, sponsors, etc. Has sport lost its fun, and its positive social impact and values? Is it geared exclusively toward winning at all costs, and supporting obsessive competitiveness that leads to violence and racial conflicts?
Context: Finite radius accretion disks are a strong candidate for launching astrophysical jets from their inner parts and disk-winds are considered as the basic component of such magnetically collimated outflows. Numerical simulations are usually employed to answer several open questions regarding the origin, stability and propagation of jets. The inherent uncertainties, however, of the various numerical codes, applied boundary conditions, grid resolution, etc., call for a parallel use of analytical methods as well, whenever they are available, as a tool to interpret and understand the outcome of the simulations. The only available analytical MHD solutions to describe disk-driven jets are those characterized by the symmetry of radial self-similarity. Those exact MHD solutions are used to guide the present numerical study of disk-winds. Aims: Radially self-similar MHD models, in general, have two geometrical shortcomings, a singularity at the jet axis and the non-existence of an intrinsic radial scale, i.e. the jets formally extend to radial infinity. Hence, numerical simulations are necessary to extend the analytical solutions towards the axis and impose a physical boundary at finite radial distance. Methods: We focus here on studying the effects of imposing an outer radius of the underlying accreting disk (and thus also of the outflow) on the topology, structure and variability of a radially self-similar analytical MHD solution. The initial condition consists of a hybrid of an unchanged and a scaled-down analytical solution, one for the jet and the other for its environment. Results: In all studied cases, we find at the end steady two-component solutions. The boundary between both solutions is always shifted towards the solution with reduced quantities. Especially, the reduced thermal and magnetic pressures change the perpendicular force balance at the “surface” of the flow. In the models where the scaled-down analytical solution is outside the unchanged one, the inside solution converges to a solution with different parameters. In the models where the scaled-down analytical solution is inside the unchanged one, the whole two-component solution changes dramatically to stop the flow from collapsing totally to the symmetry axis. Conclusions: It is thus concluded that truncated exact MHD disk-wind solutions that may describe observed jets associated with finite radius accretion disks, are topologically stable.
A variety of 2-oxoamides and related amides based on natural and non-natural amino acids were synthesized. Their activity on two human intracellular phospholipases (GIVA cPLA2 and GVIA iPLA2) and one human secretory phospholipase (GV sPLA2) was evaluated. We show that an amide based on (R)-γ-norleucine is a highly selective inhibitor of GV sPLA2.
Acute complicated diverticulitis, particularly with colon perforation, is a rare but serious condition in transplant recipients with high morbidity and mortality. Neither acute diverticulitis nor colon perforation has been reported in young heart-lung grafted patients. A case of subclinical peritonitis due to perforated acute sigmoid diverticulitis 14 years after heart-lung transplantation is reported. A 26-year-old woman, who received heart-lung transplantation 14 years ago, presented with vague abdominal pain. Physical examination was normal. Blood tests revealed leukocytosis. Abdominal X-ray showed air-fluid levels while CT demonstrated peritonitis due to perforated sigmoid diverticulitis. Sigmoidectomy and end-colostomy (Hartmann's procedure) were performed. Histopathology confirmed perforated acute sigmoid diverticulitis. The patient was discharged on the 8th postoperative day after an uneventful postoperative course. This is the first report of acute diverticulitis resulting in colon perforation in a young heart-lung transplanted patient. Clinical presentation, even in peritonitis, may be atypical due to the masking effects of immunosuppression. A high index of suspicion, urgent aggressive diagnostic investigation of even vague abdominal symptoms, adjustment of immunosuppression, broad-spectrum antibiotics, and immediate surgical treatment are critical. Moreover, strategies to reduce the risk of this complication should be implemented. Pretransplantation colon screening, prophylactic pretransplantation sigmoid resection in patients with diverticulosis, and elective surgical intervention in patients with nonoperatively treated acute diverticulitis after transplantation deserve consideration and further studies.
Sarcoidosis is a multisystem disease encountered by general physicians as well as medical specialists. Subcutaneous sarcoidosis is not an uncommon clinical presentation of sarcoidosis and is challenging for physicians because it can mimic cellulitis or several chronic infections. Our patient presented with a swollen forearm and hand which were initially treated as acute cellulitis with antibiotics by general physicians but without any improvement. A skin biopsy showed granulomatous panniculitis but confirmation of the diagnosis of systemic sarcoidosis was based on the characteristic chest roentgenogram, the high CD4/CD8 ratio of T lymphocytes in bronchoalveolar lavage, and the typical 'panda' and 'lambda' signs on the (67)Ga scan. Such cases with atypical clinical presentation cause some difficulty in reaching the diagnosis but a skin biopsy as well as typical imaging and laboratory signs are usually important to establish the diagnosis of sarcoidosis, when invasive procedures cannot be performed to get confirmation from a second target organ.
The "supercritical pile" is a very economical GRB model that provides for the efficient conversion of the energy stored in the protons of a relativistic blast wave (RBW) into radiation and at the same time produces — in the prompt GRB phase, even in the absence of any particle acceleration — a spectral peak at an energy ~ 1 MeV. We extend this model to include also the evolution of the RBW Lorentz factor Γ and thus follow the spectral and temporal features of this model into the GRB early afterglow stage. One of the novel features of the present treatment is the inclusion of the feedback of the GRB produced radiation on the evolution of Γ with radius. This way one can obtain afterglow light curves with steep decays followed by a relatively flatter flux stage, as observed in a large number of bursts.
Posterior wall fractures are the commonest type of acetabular fracture. Nonoperative management is associated with significant complications and poor outcome. Consequently, open reduction and internal fixation has become increasingly common. In this article, inaugurating the new section of "how do I do it", we present our current approach to the treatment of posterior wall fractures of the acetabulum, including the preoperative planning, the details of the operative procedure in terms of patient's positioning and draping, surgical approach, osteosynthesis and wound closure.
OBJECTIVE: To describe factors associated with survival in Alzheimer disease (AD) in a multiethnic, population-based longitudinal study.
METHODS: AD cases were identified in the Washington Heights Inwood Columbia Aging Project, a longitudinal, community-based study of cognitive aging in Northern Manhattan. The sample comprised 323 participants who were initially dementia-free but developed AD during study follow-up (incident cases). Participants were followed for an average of 4.1 (up to 12.6) years. Possible factors associated with shorter lifespan were assessed using Cox proportional hazards models with attained age as the time to event (time from birth to death or last follow-up). In subanalyses, median postdiagnosis survival durations were estimated using postdiagnosis study follow-up as the timescale.
RESULTS: The mortality rate was 10.7 per 100 person-years. Mortality rates were highest [corrected] among those diagnosed at older ages, and among non-Hispanic whites compared to [corrected] Hispanic [corrected] The median lifespan of the entire sample was 92.2 years (95% CI: 90.3, 94.1). In a multivariable-adjusted Cox model, history of diabetes and history of hypertension were independently associated with a shorter lifespan. No differences in lifespan were seen by race/ethnicity after multivariable adjustment. The median postdiagnosis survival duration was 3.7 years among non-Hispanic whites, 4.8 years among African Americans, and 7.6 years among Hispanics.
CONCLUSION: Factors influencing survival in Alzheimer disease include race/ethnicity and comorbid diabetes and hypertension.
A variety of lipophilic 2-oxoamides containing sulfonamide analogs of γ-amino acids as well as acyl sulfonamides of γ-aminobutyric acid were synthesized. Their ability to inhibit intracellular GIVA cPLA2 and GVIA iPLA2 as well as secreted GV sPLA2 was evaluated. The sulfonamide group seems a bioisosteric group suitable to replace the carboxyl group in 2-oxoamide inhibitors of GVIA cPLA2.
The development of selective inhibitors for individual PLA2 enzymes is necessary in order to target PLA2-specific signaling pathways, but it is challenging due to the observed promiscuity of known PLA2 inhibitors. In the current work, we present the development and application of a variety of synthetic routes to produce pentafluoro, tetrafluoro, and trifluoro derivatives of activated carbonyl groups in order to screen for selective inhibitors and characterize the chemical properties that can lead to selective inhibition. Our results demonstrate that the pentafluoroethyl ketone functionality favors selective inhibition of the GVIA iPLA2, a very important enzyme for which specific, potent, reversible inhibitors are needed. We find that 1,1,1,2,2-pentafluoro-7-phenyl-heptan-3-one (FKGK11) is a selective inhibitor of GVIA iPLA2 (XI(50) = 0.0073). Furthermore, we conclude that the introduction of an additional fluorine atom at the α′ position of a trifluoromethyl ketone constitutes an important strategy for the development of new potent GVIA iPLA2 inhibitors.
We use new on-land and offshore structural data and scaled analogue models to analyse the fault tectonic pattern at Nisyros Island (Greece), which has an active caldera that shows a complicated network of faults, fractures and volcano-tectonic structures. We measured 157 faults that show dominant dip-slip normal motions along planes mainly striking NE-SW, NNE-SSW, and NNW-SSE. Inside the caldera, dykes, necks and morphometric parameters of volcanic domes, explosion craters and fumarole pits indicate the control by NE-striking discontinuities on magma and gas paths. The NNW- and NE-striking faults bound a major block that underwent repeated downthrow and uplift movements during the late Pleistocene-Holocene. Experiments with scaled models of caldera resurgence and two magma chambers indicate the formation of an hourglass-shaped fault pattern, as seen in plan view, with an asymmetric increase in the fault offset and a widening of the fault divergence towards the volcano flank. All these data suggest that regional fault tectonics and stress state strongly guided magma upwelling and the emplacement of volcanic centres, whereas periodical bulging due to the overpressure of a second magma chamber located northwest of the caldera combined with faulting due to tectonic stresses, can account for the overall deformation field.
Thalidomide with dexamethasone (thal-dex) is an active therapy for patients with relapsed or refractory multiple myeloma (MM). In this Practice Point, we discuss the findings of a trial by Rajkumar et al. that aimed to compare the response rate, time to progression and progression-free survival among previously untreated patients with MM who received either thal-dex or placebo plus dexamethasone. The thal-dex regimen was associated with a significantly higher response rate at the expense of more-frequent adverse effects, in particular deep-vein thrombosis, which occurred in almost 20% of patients. Median time to progression was three times longer with thal-dex than with placebo plus dexamethasone, but was shorter, however, than the time to progression observed in studies in which thalidomide or bortezomib was added to melphalan and prednisone. Nevertheless, thal-dex is a convenient oral and relatively inexpensive non-myelosuppressive regimen, which can be used in patients with previously untreated MM.
Aims: The purpose of this study is to find transient X-ray sources in M 31 and to investigate and classify their nature. Methods: Three X-ray transients were observed with Swift. For each of the three X-ray transients, we used the Swift X-ray and optical data with observations from XMM-Newton and Chandra to investigate the lightcurves and the spectra of the outburst, thereby identifying the source types. Results: The outburst of XMMU J004215.8+411924 lasted about one month. The source had a hard power-law spectrum with a photon index of 1.6. It was previously identified as a Be/X-ray binary based on the optical identification with a star. However, we show that, with improved source coordinates it is clear that the optical source is not the counterpart to the X-ray source. The source SWIFT J004217.3+411532 had a bright outburst, after which it slowly decayed over half a year. The spectrum was soft, corresponding to a thermal accretion disc with an innermost temperature of ~250-600 eV. The source was not seen in the optical, and the soft spectrum indicates that the source is most likely a black-hole low-mass X-ray binary. M31N 2006-11a is a nova that was previously observed in the optical. We detected it both in X-rays and UV with Swift ~half a year after the optical maximum, after which it decayed below the Swift detection threshold within a month. The spectrum of the X-ray transient can be modelled by a black-body with a temperature of 50 eV. We use catalogues of X-ray transients in M 31 to estimate their rate, and we find a lower limit of 9 yr-1.
The purpose of the present study was to investigate the effect of short-term resistance training and detraining on shot put throwing performance. Eleven young healthy subjects with basic shot put skills participated in 14 weeks of resistance training, which was followed by 4 weeks of detraining. Shot put performance in four field tests was measured before (T1) and after (T2) resistance training and after detraining (T3). At the same time points, one repetition maximum (1RM) was measured in squat, bench press, and leg press. Fat-free mass (FFM) was determined with dual x-ray absorptiometry and muscle biopsies obtained from vastus lateralis for the determination of fiber type composition and cross-sectional area (CSA). 1RM strength increased 22-34% (p < 0.01) at T2 and decreased 4-5% (not significantly different) at T3. Shot put performance increased 6-12% (p < 0.05) after training and remained unaltered after detraining. FFM increased at T2 (p < 0.05) but remained unchanged between T2 and T3. Muscle fiber CSA increased 12-18% (p < 0.05) at T2. Type I muscle fiber CSA was not altered after detraining, but type IIa and IIx fiber CSA was reduced 10-12% (p < 0.05). The percentage of type IIx muscle fibers was reduced after training (T1 = 18.7 +/- 4, T2 = 10.4 +/- 1; p < 0.05), and it was increased at T3 compared with T2 (T3 = 13.7 +/- 1; p < 0.05). These results suggest that shot put performance remains unaltered after 4 weeks of complete detraining in moderately resistance-trained subjects. This might be linked to the concomitant reduction of muscle fiber CSA and increase in the percentage of type IIx muscle fibers.
OBJECTIVE: Thyroid disease has been associated with leukemia and lymphoma. No previous study using clinical and laboratory data has explored whether thyroid disease and especially autoimmune thyroid disease (ATD) is associated with myelodysplastic syndrome (MDS) risk. In this case-control study, we investigated the association of ATD with MDS.
METHODS: Our study included 101 cases with incident primary MDS confirmed by histology and cytogenetics, and 101 controls matched on gender and age, admitted for non-neoplastic and non-infectious diseases. All subjects were submitted to clinical, ultrasound thyroid evaluation and serum free T3, free T4, TSH, thyroglobulin, and thyroperoxidase antibodies determination.
RESULTS: Adjusting for age, gender, and body mass index, there was statistically significant evidence that ATD is associated with increased risk of MDS (OR = 2.58, 95% CI 1.29-5.16). Interestingly, ATD starting from the remote past (more than 10 years from MDS onset) was positively associated with MDS risk (OR = 5.73. 95% CI 2.03-16.16). Mean serum levels of fT3, fT4, and thyroid antibodies were significantly higher in MDS patients and mean TSH serum levels were significantly lower in MDS patients than in controls (p < 0.05).
CONCLUSION: Biological plausibility and empirical evidence highlights the importance of ATD in MDS etiopathogenesis. Further studies are needed to explore underlying mechanisms associating thyroid autoimmunity with leukemogenesis.
Pantos C, Mourouzis I, Xinaris C, Cokkinos DV. Thyroid hormone and myocardial ischaemia. The Journal of steroid biochemistry and molecular biology. 2008;109:314–322.
BACKGROUND: This study was conducted to compare the outcome of total thyroidectomy using the electrothermal bipolar vessel sealing system, the harmonic scalpel, and the classic suture ligation technique.
METHODS: This was a retrospective study of prospectively collected data from 382 consecutive total thyroidectomies from September 2004 to August 2006. Patients were divided into 3 groups: group SL patients (n = 90) underwent total thyroidectomy with the classic suture ligation technique, group L (n = 148) with the electrothermal bipolar vessel sealer, and group U (n = 144) with the harmonic scalpel. The main outcomes measured were surgical and hospitalization time, intraoperative and postoperative bleeding, postoperative hypocalcemia, and superior and inferior laryngeal nerves injuries.
RESULTS: The 3 groups were similar in terms of demographics, thyroid gland weight and pathology, perioperative complications, and hospital stay. Compared with the classic technique, surgical time was reduced significantly by about 20% when the bipolar vessel sealer or harmonic scalpel was used (93.3 +/- 12.5 vs 74.3 +/- 14.2 and 73.8 +/- 13.8 min, P = .001, and P = .001, respectively).
CONCLUSIONS: Both the bipolar vessel sealer and harmonic scalpel are safe, useful, and time-saving alternatives to the traditional suture ligation technique for thyroid surgery. Because no differences were observed regarding these 2 devices, the choice should be made based on the surgeon's preferences and experience.
We report a consistent derivation of a tight-binding formalism, both in the frequency and in the time domain, for the analysis of electromagnetic energy transfer in single-mode cavity-plasmon waveguides. Moreover, we derive closed-form solutions of the relevant tight-binding equations, which describe the response of these waveguides under time-varying excitations by a localized light source. In this context, we discuss the possibility of efficient single-mode waveguiding through coupled cavity-plasmon modes in chains of spheroidal silicon nanoparticles in silver at optical frequencies.
We present the mathematical formulation and numerical results for the resonance characteristics of the TMmp modes in a coaxial cavity with a longitudinally corrugated insert. Based on the spatial harmonics method, the eigenvalues of the transverse plane are calculated, and then, the Vlasov approximation is used to calculate the resonance frequency, diffractive quality factor, and longitudinal field profile of every mode. The numerical results are presented and compared with those found in the literature.
A 52-year-old man presented with a 3-week history of right knee pain, significant enough to prevent weight bearing. There was no history of knee injury or disease. On knee examination, an effusion and medial joint line tenderness was noted. Knee range of motion was full, but painful. Radiographs revealed minor osteoarthritic changes. Laboratory values were within normal limits, including those associated with infection. Magnetic resonance imaging showed decreased signal intensity on T1-weighted images within the medial femoral condyle and corresponding increased signal intensity on T2-weighted consistent with bone marrow edema as well as edema to the adjacent soft tissues. Bone scanning showed increased uptake of radioisotope in the medial femoral condyle. The patient was diagnosed with bone marrow edema syndrome, and managed medically with analgesics and continued non weight-bearing status. At the 1-month follow-up, his symptoms had improved significantly. The patient progressively increased weight bearing as tolerated over the subsequent weeks. At 12-week follow-up, symptoms had completely resolved. Magnetic resonance imaging showed no signal abnormalities in the affected knee. Transient osteoporosis is an uncommon and typically self-limiting condition that can be challenging to diagnose and treat. The clinician must be aware of this entity, as well as its typical course, to prevent unnecessary testing and invasive intervention.
The authors examined the effectiveness of the local anti-microbial treatment on methicillin resistant Staphylococcus aureus (MRSA) experimental osteomyelitis. Thirty-six rabbits with chronic MRSA osteomyelitis of the right femur were treated with local grepafloxacin delivery system prepared by a mixture of acrylic bone cement (polymethyl methacrylate, PMMA) plus 4% grepafloxacin. Osteomyelitis was induced by inoculating MRSA (100 microl of cultured bacteria; 10(7)) and the local insertion of a needle, serving as a foreign body, at the upper third of the femur. The course of the infection was followed by clinical, radiographic and microbiological examination. In the third week, all animals were re-operated, needles were removed, and antibiotic containing acrylic cement was implanted. Thereafter, one control and five treated animals were sacrificed per week, within 6 weeks. Osteomyelitis was found in all rabbits. In vitro grepafloxacin levels remained high throughout the 6 weeks of the experiment. Histologically tissue reaction against the cement was not observed. Osteomyelitis lesions and bone structure were progressively repaired after cement implantation. Biomechanical analysis showed no significant influence on the mechanical properties of acrylic cement due to grepafloxacin. The above mixture could prove to be an important supplementary method for the treatment of bone infections. Such a system could replace the use of gentamycin PMMA beads in the treatment of patients with chronic osteomyelitis due to MRSA. Furthermore, the proposed method could be used as a spacer after removal septic loosened prostheses in combination with systemic administration of antibiotics.
Renal failure is a common feature of multiple myeloma and a major management problem. However there is limited data regarding the reversibility of renal failure, the kinetics of serum creatinine and the safety of novel agents such as bortezomib when administered to newly diagnosed or relapsed/refractory patients with renal failure. Patients and Methods. We evaluated 20 consecutive patients with newly diagnosed or relapsed/refractory multiple myeloma and renal failure, defined as a serum creatinine ≥ 2 mg/dl. All patients received bortezomib with dexamethasone or in combination with other agents (thalidomide, doxorubicin or melphalan). Results. Reversal of renal failure was documented in 40% of all patients and the median time to reversal was 17 days. Moreover 10 patients (50%) had 50% decrease in serum creatinine and the median time to decrease was 35 days. Some decrease of creatinine was documented in 85% of patients. The objective response rate was 65%. Toxicities were similar to those seen in myeloma patients without renal failure. Conclusions. Bortezomib based regimens can be administered to myeloma patients with renal impairment and their toxicity and efficacy are similar to those observed in patients without renal impairment. Moreover, bortezomib-based regimens induce improvement of serum creatinine in most patients and reversal of renal failure in approximately one-third.
Lenalidomide is an immunomodulatory drug, structurally related to thalidomide, with pleiotropic activity including antiangiogenic and antineoplastic properties. It is the product of advances in our understanding of the biology of myeloma cells, their interactions with the microenvironment and of the underlying molecular pathways. In preclinical and clinical studies, lenalidomide was more potent and less toxic than thalidomide. Subsequent phase II and III studies confirmed the activity of lenalidomide either as a single agent or in combination with dexamethasone in relapsed or refractory myeloma patients, whereas combinations with chemotherapy induce high response rates and durable remissions. Lenalidomide has been used successfully as an upfront treatment either with high or low dose dexamethasone or with melphalan and prednisone, resulting in high overall response and complete response rates and excellent 1-year survival. Lenalidomide causes less neuropathy than thalidomide; however, the risk of thromboembolism is high, especially in patients treated with lenalidomide and steroids. In this review, we summarize the mechanisms of action, toxicity and clinical activity, and the current role of lenalidomide in patients with multiple myeloma or other related plasma cell disorders.
Primary objective: Granulocyte-colony stimulating factor (G-CSF) is used for the mobilization of bone marrow and endothelial progenitor cells, though G-CSF-induced inflammation may cause endothelial dysfunction. We examined the effects of G-CSF on endothelium, C-reactive protein (CRP), tumour necrosis factor-α (TNF-α) and anti-inflammatory cytokines namely interleukin 10 (IL-10). Research design: We studied 60 women with breast cancer, who were randomized to either subcutaneous G-CSF (5 μg/kg), o.d. for 5 days after adjuvant chemotherapy (n = 40) or placebo (n = 20). Experimental interventions: We measured flow-mediated dilatation (FMD%) of the brachial artery by ultrasonography, CRP, TNF-α, IL-10 and the ratio TNF-α/IL-10 blood levels before, 2-h and 5-days after the G-CSF or placebo treatment. Main outcomes and results: There was a greater increase of FMD, IL-10 and reduction of TNF-α/IL-10, 2 h and 5 days after the G-CSF treatment compared to placebo. Although, CRP and TNF-α were higher, TNF-α/IL-10 was lower at the end of G-CSF treatment compared to placebo. Improvement of FMD was related to changes of IL-10 and TNF-α/IL-10. Conclusions: Treatment with G-CSF improves endothelial function in vivo, possibly by shifting the balance between the pro- and anti-inflammatory cytokines.
We report the discovery of two new, bright possible novae in M 31 on dithered stacked R filter CCD images, obtained on 2008 August 09, with the 1.3m Ritchey Chretien f/7.5 telescope at Skinakas Observatory, Crete, Greece, using an Andor DZ436-BV CCD Camera (with a Marconi 2k x 2k chip with 13.5µm sq. pixels). The first object is visible in two different pointings of four images taken on 2008 August 09.96 and three images taken on 2008 August 09.97, respectively.
Recently, several works have focused on the lacertid lizards of the genus Podarcis, revealing cases of hidden diversity and paraphyly, and offering evidence that suggests the revision of the extant taxonomical arrangements within the genus. Hidden diversity and paraphyly have been shown to exist in the relationships betweentheBalkan species P. peloponnesiacaandP. erhardii as well. Herewecouple a molecular (mtDNA) dataset with a corresponding morphological one, consisting of morphometric and pholidotic characters, to check for concordance between the two. Phylogenetic analyses reinforced previous suggestions for paraphyly of P. erhardii with respect to P. peloponnesiaca.We found the variation of certain pholidotic characters concordant with the relationships inferred from partial mtDNA sequences, whereas morphometric characters were not. The latter is possibly due to greater influence of morphometric characters by environmental factors. To avoid the observed paraphyly we proceed with the description of the populations from Crete and the islet of Pori, until now designated as P. erhardii, as separate taxa at the species level.
Context: Observations of collimated outflows in young stellar objects indicate that several features of the jets can be understood by adopting the picture of a two-component outflow, wherein a central stellar component around the jet axis is surrounded by an extended disk wind. The precise contribution of each component may depend on the intrinsic physical properties of the YSO-disk system as well as its evolutionary stage. Aims: This article reports a systematic separate investigation of these jet components via time-dependent simulations of two prototypical and complementary analytical solutions, each closely related to the properties of stellar outflows and disk winds. These models describe a meridionally and a radially self-similar exact solution of the steady-state, ideal hydromagnetic equations, respectively. Methods: Using the PLUTO code to carry out the simulations, the study focuses on the topological stability of each of the two analytical solutions, which are successfully extended to all space by removing their singularities. In addition, their behavior and robustness over several physical and numerical modifications is extensively examined. Therefore, this work serves as the starting point for the analysis of the two-component jet simulations. Results: It is found that radially self-similar solutions (disk winds) always reach a final steady-state while maintaining all their well-defined properties. The different ways to replace the singular part of the solution around the symmetry axis, being a first approximation towards a two-component outflow, lead to the appearance of a shock at the super-fast domain corresponding to the fast magnetosonic separatrix surface. These conclusions hold true independently of the numerical modifications and/or evolutionary constraints that the models have undergone, such as starting with a sub-modified-fast initial solution or different types of heating/cooling assumptions. Furthermore, the final outcome of the simulations remains close enough to the initial analytical configurations, thus showing their topological stability. Conversely, the asymptotic configuration and the stability of meridionally self-similar models (stellar winds) is related to the heating processes at the base of the wind. If the heating is modified by assuming a polytropic relation between density and pressure, a turbulent evolution is found. On the other hand, adiabatic conditions lead to the replacement of the outflow by an almost static atmosphere.
Supernova remnant (SNR) blast shells can reach the flow speed $v_s = 0.1 c$ and shocks form at its front. Instabilities driven by shock-reflected ion beams heat the plasma in the foreshock, which may inject particles into diffusive acceleration. The ion beams can have the speed $v_b \approx v_s$. For $v_b \ll v_s$ the Buneman or upper-hybrid instabilities dominate, while for $v_b \gg v_s$ the filamentation and mixed modes grow faster. Here the relevant waves for $v_b \approx v_s$ are examined and how they interact nonlinearly with the particles. The collision of two plasma clouds at the speed $v_s$ is modelled with particle-in-cell (PIC) simulations, which convect with them magnetic fields oriented perpendicular to their flow velocity vector. One simulation models equally dense clouds and the other one uses a density ratio of 2. Both simulations show upper-hybrid waves that are planar over large spatial intervals and that accelerate electrons to $\sim$ 10 keV. The symmetric collision yields only short oscillatory wave pulses, while the asymmetric collision also produces large-scale electric fields, probably through a magnetic pressure gradient. The large-scale fields destroy the electron phase space holes and they accelerate the ions, which facilitates the formation of a precursor shock.
Plasmonic excitations in two- and three-dimensional ordered assemblies of metal-dielectric-metal nanosandwiches are studied by means of full-electrodynamic calculations using the layer-multiple-scattering method. Plasmon hybridization results in collective electric-dipole-like and magnetic-dipole-like resonant modes, which are directly controlled by the lattice constant and the geometrical characteristics of the building units. It is shown that, in planar arrays of such composite nanoparticles on a dielectric substrate, the magnetic resonance induces a negative effective permeability, as large as −2 , which can be tuned within the range of near-infrared and visible frequencies. However, as successive layers are stacked together to build a three-dimensional crystal, the region of negative effective permeability shrinks and disappears for relatively thick slabs. Our analysis demonstrates that the complex photonic band structure is a valuable tool in the study of three-dimensional metamaterials and their effective-medium description.
BACKGROUND: Unintentional parathyroidectomy during thyroidectomy has been evaluated in a few studies. Moreover, the impact of the surgeon's experience and operative technique has not been evaluated. Our aim was to identify the incidence of unintentional parathyroidectomy during total thyroidectomy, its clinical consequences, and factors affecting its occurrence.
METHODS: We reviewed all total thyroidectomies during a 2-year period. Patients were categorized into 2 groups: those with unintentional parathyroidectomy (parathyroidectomy group) and those without unintentional parathyroidectomy (no-parathyroidectomy group).
RESULTS: Incidental parathyroidectomy occurred in 100 (19.7%) of the 508 patients. The groups were comparable in age, thyroid weight and pathology, operative time, surgeon experience (high/low volume), operative technique (suture-ligation, LigaSure, or Ultracision), postoperative calcium, and transient hypocalcemia. No permanent hypocalcemia occurred. However, 11% of the parathyroidectomy group was men compared with 22% of the no-parathyroidectomy group (p =.002).
CONCLUSIONS: Unintentional parathyroidectomy, although common, has no clinical consequences. Unlike surgeon's experience and operative technique, patient sex was the only factor affecting its occurrence.
In this paper the counteractive dynamic marine and river environments responsible for a river mouth’s and a delta’s modulation is studied. The Acheloos River (West Greece) was chosen as the case study due to the recent changes taken place in its basin. The aim of this study is to analyze the present dominant environment and the impact of human activity on this balance. A GIS database was developed and updated in order to provide access for future use and computer analysis (both spatial and chronological). The study, includes an estimation of the delta forming processes, the impact of the anthropogenic parameters on these processes, and, finally, their representation.
Background. The utilization of modern achievements from nanobiotechnology has resulted in novel modalities for renal replacement therapy. For conventional intermittent haemodialysis (HD), sophisticated membranes are currently being manufactured that guarantee selective removal of target toxins. These membranes have a narrow pore-size distribution that is focused around a mean value at the nanometre level. For continuous HD, novel artificial renal devices are currently being designed and evaluated in in vitro experiments that will be both implantable and have continuous function. Methods. We present mock-dialysis experiments using magnetically assisted HD (MAHD) that we very recently introduced for the selective removal of target toxins. MAHD is based on the preparation of conjugates (Cs) made up of biocompatible ferromagnetic nanoparticles (FNs) and a specifically designed targeted binding substance that must have a high affinity for a specific target toxin substance. The FN-targeted binding substance Cs should be administered to the patient prior to MAHD to allow for binding with the target toxin substance in the bloodstream. The complex FN-targeted binding substance-target toxin substance will then be removed by a 'magnetic dialyzer' that is installed in the dialysis machine in series to the conventional dialyzer. In the present work, we compared the in vitro efficiency of MAHD to conventional HD for the removal of homocysteine (Hcy) during mock-dialysis experiments.
Results. These mock-dialysis experiments performed on Hcy revealed that both the removal rate and the overall removal efficiency of MAHD were significantly greater than conventional HD.
Conclusions. MAHD appears to be a promising method that can be employed for the selective and more efficient extraction of toxins that are not adequately removed by conventional HD.
Living coccolithophores were collected in August 2001, at different photic depths (0-120 m), form 8 stations along a transect in the gulf of Korthi (Andros island). The analysis of the vertical distribution of coccolithophores certified high differentiation in density and diversity, as well as in the species composition at different depth levels. As a result, the photic zone is separated into three distinct sub-zones: upper (0-25 m depth), middle (45-60 m depth) and lower (90-120 m depth). The total cell density varies between 14.7x103 cells/l and 1.9x103 cells/l, and is usually higher in the upper and middle photic zone, while in the lower photic zone it gradually decreases. The highest species richness (max=34 taxa) was observed at the middle photic zone. Emiliania huxleyi, Rhabdosphaera clavigera and holococcolithophores preferred the upper photic zone. On the contrary, in the lower photic zone, the presence of Florisphaera profunda and Algirosphaera robusta becomes important, making up the typical deep community. Umbellosphaera tenuis is an additional important component of the summer heterococcolithophore nannoflora, especially in the middle photic zone. The studied coastal marine coccolithophore communities indicate that temperature and availability of nutrient concentrations are the most important controlling factors controlling their vertical distribution.
The incidence of proximal femoral fractures has increased significantly in recent years, and is expected to continue to rise with increasing life expectancy. However, the optimal method of treatment of these fractures is still debated. This article summarises current evidence concerning the most controversial issues in the treatment of intracapsular and extracapsular proximal femoral fractures. Despite initial enthusiasm, many new treatment options have been proved inferior to older, traditional methods, and physicians should be cautious when it comes to managing these fractures. It seems that meticulous surgical technique and implant selection according to fracture pattern and the characteristics of the individual patient offer the best route to optimal final outcome.
Στη θεωρητική αυτή εργασία εξετάζεται η ηλικιακή περίοδος από το 18ο μέχρι το 25ο έτος περίπου υπό το πρίσμα μιας καινούριας θεώρησης που χαρακτηρίζει την περίοδο αυτή ως «αναδυόμενη ενηλικίωση» (Arnett, 2004) και με βάση σχετικές έρευνες κυρίως από τις Η.Π.Α. και τη Δ. και Β. Ευρώπη, οι οποίες ανασκοπούνται. Αρχικά, επιχειρούνται αποσαφηνίσεις της έννοιας αυτής και η διάκρισή της από άλλους όρους που έχουν χρησιμοποιηθεί για να αποδώσουν την ίδια περίοδο. Στη συνέχεια, περιγράφονται τα γενικά χαρακτηριστικά της αναδυόμενης ενηλικίωσης και εντοπίζονται κοινωνικο-πολιτισμικές παράμετροι με τις οποίες συνδέεται η ύπαρξη και η αναγνώρισή της. Παρουσιάζονται αναλυτικά οι αντιλήψεις των νεαρών ατόμων για την ηλικία αυτή, καθώς και τα αναπτυξιακά χαρακτηριστικά τους και, τέλος, συνδέεται η αναδυόμενη ενηλικίωση με τη φοίτηση στην τριτοβάθμια εκπαίδευση.
Η ελληνική γλώσσα από την ομηρική αρχαιότητα μέχρι τη σύγχρονη εποχή αξιοποίησε το επιρρηματικό πρόθεμα «ευ» με πολλαπλούς τρόπους, αναδεικνύοντας ιδιότητες και αξίες ή φωτίζοντας ηθικά νοήματα. Το ‘ευ’, παρότι σύντομο, δρα ανατρεπτικά, καθώς εισηγείται την διαφοροποίηση της ποιότητας της λέξης. Η προσθήκη του ‘ευ’ στο ουσιαστικό ‘δαίμων’, επί παραδείγματι, συνθέτει τη λέξη που, κατά τον Αριστοτέλη, αποτελεί τον υψηλότερο σκοπό της ζωής, δηλαδή τον ευ-δαίμονα, καθώς και την ευδαιμονία και την ευτυχία. Το θαυματουργό ‘ευ’ εμπεριέχει μια πολύτιμη δυναμική, την οποία προβάλλει σ’ εκείνη τη λέξη που θα έχει την εύνοιά του. Η θετική αυτή εμφάνιση κατορθώνει την αντιστροφή της ατυχίας και όλων όσων αρνητικών περιέχουν οι έννοιες εκείνες στις οποίες προπορεύεται το άλφα-στερητικό ή το ‘κακός’, όπως το κακοτυχία, το κακοδαιμονία ή το αζωΐα. Έτσι, με τη μαγική εσωτερική του δύναμη, αφού κατορθώνει έναν απλό ‘λόγο’ να τον μετατρέψει σε ευ+λόγο, ήτοι σε ‘ευλογία’, το ‘ευ’ αποτελεί κάτι το περιζήτητο, όχι μόνο επειδή θέτει τα όρια της ηθικής, αλλά, επιπλέον, γιατί συνιστά το όριο υπέρβασης της μετριότητας.
Το «ευ ασκείσθαι» υπήρξε καθολικό βίωμα των Ελλήνων, σε όλες τις εκφάνσεις της πολιτιστικής τους δραστηριότητας. Κατά την κλασική περίοδο όμως της ελληνικής αρχαιότητας η αίσθηση της αξίας του ‘ευ’ και του ‘καλού αγώνα’, φτάνει στο απόγειό της. Η ομηρική αριστεία εξανθρωπίζεται, λαμβάνοντας μια διάσταση πιο ανθρώπινη, η οποία προσιδιάζει στο ιδανικό του τέλειου ανθρώπου. Ο εναρμονισμός των ανθρώπινων υποστάσεων μέσω της γύμνασης και της μουσικής εξυπηρετεί την ιδέα του καλού κ’ αγαθού πολίτη, του ανθρώπου της μεσότητας, καθώς και την ιδέα του ευ ζειν. Ο αθλητικός αγώνας συνιστά μια προέκταση των αρετών του ιδανικού πολίτη. Στην έννοια του «ευ» αποτυπώνεται η ηθική αντίληψη του κλασικού κόσμου, η οποία προβάλλεται και στους αγώνες. Οι λέξεις που ως πρώτο συνθετικό έχουν το ‘ευ’ ή το ‘καλός’, συνιστούν αρετές σώματος και ψυχής, και ως τέτοιες υπόκεινται σε αγώνα και σε κρίση.
Στο σύγχρονο κόσμο, αντί του ‘ευ αγωνίζεσθαι’, επικράτησε ο όρος “Fair Play”, κυρίως, χάρη στη χρήση του από τα Βρετανικά Δημόσια Σχολεία του 19ου αιώνα, τα οποία με την σειρά τους διεκδικούσαν ρίζες στον κλασικό ελληνικό αθλητισμό. Στα μέσα του 19ου αιώνα ο αθλητισμός αποτελούσε την αποκλειστικότητα μιας ταξικής ελίτ, των μορφωμένων, αριστοκρατών και αργόσχολων ανδρών, οι κοινές αξίες των οποίων επεκτείνονταν και στις αθλητικές τους συνήθειες. Ο εκδημοκρατισμός του αθλητισμού επέτρεψε την είσοδο αθλητών από πολύ ευρύτερη ποικιλία προπαίδειας, ενώ σιγά-σιγά ακόμη και γυναίκες επικράτησε να συμμετάσχουν στον αθλητισμό. Οι παλιές ξεκάθαρες αντιλήψεις, όμως, μερικές φορές δεν αντανακλώνταν, πλέον, στις πρακτικές των αθλητών. Το «ευ αγωνίζεσθαι» ως έννοια σε ορισμένες περιπτώσεις σήμαινε περισσότερο την επιθυμία να χρησιμοποιηθούν τα αθλήματα για τη διδαχή κάποιων θετικών αξιών, παρά το στόχο να γίνει κατανοητή η φύση της ίδιας της έννοιας. Πάνω σ’ αυτήν την αντίληψη το «ευ αγωνίζεσθαι» διαμορφώνει ένα σύνολο γενικών ηθικών ή κοινωνικών αξιών που διδάσκονται μέσα από τα αθλήματα και τη σωματική δραστηριότητα.
Η ευ-γενής άμιλλα, ως εκ τούτου, λειτουργεί διαχρονικά ως στοιχείο ηθικής αγωγής, αποτελώντας, δικαίως, τον πυρήνα του αθλητικού ιδεώδους. Λειτουργεί ως ασπίδα στην επίθεση ενός παράλογου ανταγωνισμού, ο οποίος μετατρέπει την αγαθή έριδα σε ανελέητη μάχη. Η ισχύς του «ευ αγωνίζεσθαι» εξαρτάται, ωστόσο, παράλληλα, και από άλλες αρχές, τις οποίες οφείλει ν’ αναγνωρίζει ο αθλητής εξίσου: την ισονομία, την αξιοκρατία, τη δημοκρατία, καθώς και την αδιάκοπη προσπάθεια περιφρούρησης του αθλητισμού από την ευκολία, τους «στημένους αγώνες», τους ιδιοτελείς παράγοντες και τις κατευθυνόμενες συνειδήσεις. Ο συνδυασμός των αξιών αυτών ασκεί αποτελεσματική πολεμική τακτική ενάντια στα αθέμιτα μέσα που περιβάλλουν τον αθλητισμό. Στην Ελλάδα, τη χώρα της σμίλευσης της αρμονίας λόγου και πράξης, εδώ και τέσσερις χιλιετίες ξεπήδησε η ιδέα της σωματικής δραστηριότητας ως μέσου ανύψωσης του ανθρώπου, καθώς και αυτή του αγώνα ως τρόπου επίδειξης του ηρωικού πνεύματος. Οι ιδέες αυτές εξελίχθηκαν, ενισχύοντας την αξία της γύμνασης ως μέσου συνένωσης της φυσικής ενέργειας και της ζωηρότητας του πνεύματος. Όλη αυτή η αξιοποίηση συντελέστηκε με την αρωγή εκείνων των αρετών που διέπουν τον υγιή αθλητισμό. Δεν της αξίζει, ως εκ τούτου, αυτής της χώρας, σαν συνέχεια η κακοδαιμονία, η απληστία, το ευέξαπτο, το ευτελές, το εύκολο, το κακοπροαίρετο. Αντιθέτως, της αξίζει να προκύπτουν από το χώρο του αθλητισμού νοήματα θετικά, συνδεόμενα με το ‘ευ’, όπως ευχαρίστηση, ευφορία, ευσυνειδησία, ευνομία, καθώς και αθλητές και θεατές που διαθέτουν ευγένεια, ευαισθητοποίηση, ευθυκρισία, ευθύνη, ευπρέπεια, όντες ευαγείς.
In this essay, we describe, compare and comment on various psychoanalytic approaches to loneliness. Loneliness has long been neglected by psychologists and psychiatrists, and there are very few studies on the psychoanalytic interpretation of this universal human condition. After some conceptual clarifications, the developmental origins of loneliness are discussed (on the basis of Mahler’s and Stern’s theories). Subsequently, the relation of loneliness to anxiety and narcissism is analyzed, drawing from the Freudian framework, as well as the theories of Klein, Bion, Bowlby, Zilboorg, Kohut, Kernberg, and Balint. Other facets of the pathology of loneliness are discussed, such as the loneliness of the depressed and the borderline individual (Freud, Fairbairn, Guntrip, Kernberg). Finding solace in alternative worlds (e.g., phantasies, illusions, manic defenses, obsessive acts) is a way of dealing with painful loneliness, described in this essay. The capacity to play and to live in the location of cultural experience, according to Winnicott, are evaluated as fundamental ways of making creative use of aloneness. Solitude or beneficial aloneness – a human state highly neglected by psychology (theory and research) – is psychoanalytically approached in the theories of Freud, Winnicott, Storr, and Quinodoz. Moreover, the notion of the private self (Winnicott, Bollas, Stern, Modell, Ogden) is also developed in relation to solitude. In conlusion, the role that loneliness has played in the lives of several psychoanalysts is stressed, and an attempt to delineate the many faces of loneliness is made.
Ο σύγχρονος αθλητισμός, από πολιτικής και οικονομικής επόψεως, ανήκει σε ευνομούμενες χώρες, ενώ για τις χώρες που έχουν προβλήματα επιβίωσης ο αθλητισμός συνιστά πολυτέλεια - εκτός αν εξαιρέσει κανείς τις περιοχές των εθνικοαπελευθερωτικών κινημάτων, όπου ασκούνται στρατιωτικά για να διατηρούν την φυσική τους κατάσταση σε καλό επίπεδο, και πάλι όμως για λόγους επιβίωσης. Η σύγκριση αυτή καθιστά φανερό πως η αξία του αθλητισμού έρχεται δεύτερη, συγκριτικά με τη μάθηση της γλώσσας, της ιστορίας, της αριθμητικής και των συναφών αντικειμένων στις χώρες όπου προέχει ο αγώνας της επιβίωσης. Στην Ελλάδα όμως, και γενικότερα στα κράτη της δυτικής Ευρώπης, που διαθέτουν ένα προηγμένο πολιτικό σύστημα και τον λεγόμενο ‘δυτικό πολιτισμό’, δεν μπορεί κανείς ν’ αφαιρεί ή ν’ αγνοεί το δικαίωμα της σωματικής άσκησης και κουλτούρας. Αθλητική παιδεία, όμως, δεν μπορεί να πραγματοποιηθεί χωρίς παράλληλες, εκπαιδευτικές, οικολογικές και πολιτιστικές υποδομές. Η ανάπτυξη όλων αυτών επικοινωνεί σ’ ένα σχήμα συγκοινωνούντων δοχείων, που αλληλεπιδρούν. Κέντρο αυτής της συμφωνίας είναι η βελτίωση του επιπέδου της ζωής και η αίσθηση οτι ζει κανείς όπως του αξίζει: Μια καθημερινότητα ανάλογη της ανθρώπινης υπόστασης, αντάξια όχι μόνο της αντικειμενικής, αλλά και της υποκειμενικής του ποιότητας, και του επιπέδου του προσωπικού πολιτισμού του. Η ύπαρξη, συνεπώς, του αθλητισμού προϋποθέτει κάποιο οντολογικής φύσεως ερώτημα: τι είδος ανθρώπου δηλαδή και τι είδος κοινωνίας επιθυμεί κανείς να δημιουργήσει;
Η απάντηση σ’ ένα τέτοιο ερώτημα προϋποθέτει την διασαφήνιση της ποιότητας του πολιτικού συστήματος στο οποίο προσβλέπει, ώστε να δοθούν ιδεολογικά χαρακτηριστικά στην ‘παιδεία’ και τον ‘πολιτισμό’ που παράγουν τις αντίστοιχες αξίες. Στο πλαίσιο μιας καπιταλιστικής οικονομίας, δηλαδή μιας γενικευμένης εμπορευματικής και ανταγωνιστικής οικονομίας, πόσο εφικτή είναι η ανατροπή της κυρίαρχης ιδεολογίας που αντανακλάται στην παιδεία; Η νευρωτική ιδεολογία της αποτίμησης και της αναγνωρισμένης αξιοποίησης, η τάση κοινωνικής αντικειμενικοποίησης των αξιών, στην οποία και ο αθλητισμός όπως τόσες άλλες κοινωνικές δραστηριότητες εντάσσονται, μπορούν ν’ αντικατασταθούν με οτιδήποτε αναφέρεται ως «υγιές», «αυθεντικό», «φυσικό» και «αληθινό»; Αν ναι, τότε, αντί για τη χειραγώγηση ή την απώθηση του αυθεντικού σώματος, θα μπορεί κανείς να μιλήσει για το παιχνίδι, την αίσθηση, τη συγκίνηση, τη μνήμη του σώματος, που έχουν και πνευματικές διαστάσεις. Αντί για τον καταπιεστικό χαρακτήρα του πολιτισμού και της εκπαίδευσης θα μπορεί κανείς να μιλήσει για ελευθερία, και όχι ελευθεριότητα. Αντί για ένα σώμα που θα είναι πηγή δυσφορίας και έλλειψης ικανοποίησης, θα μιλήσει για «αυθεντικό σώμα», που δεν θα είναι ακρωτηριαστικό, αντιαισθητικό κι εκμεταλλευτικό. Τότε η αθλητική δραστηριότητα θα λάβει τον χαρακτήρα της πολιτιστικής κατάκτησης και της πρακτικής εφαρμογής μιας ηθικής, ενώ στην εκπαίδευση, που είναι προέκταση του πολιτισμού και της κουλτούρας, θ’ ανακτήσει έναν διαπαιδαγωγικό, παιδευτικό χαρακτήρα.
Επεξεργαζόμαστε τις μαρτυρίες (στις αρχές του 20ου αιώνα) που αφορούν το θέμα της βίαιης εξολόθρευσης των Ελλήνων και άλλων αυτόχθων αλλοεθνών του Πόντου και της Μικρά Ασίας που άρχισε με την εξαφάνιση των νεολαίων-ανδρών στα εργατικά τάγματα και συνεχίστηκε με τις μαζικές σφαγές, τις μαζικές εκτοπίσεις και τον απαγχονισμό. Η Μάστιγα του Τρομερού Φόβου, τρομοκρατία, συνεχής τρόμος, ο αφανισμός όλων των στοιχείων που δεν είναι καθαροί Μουσουλμάνοι, δικτατορία, μίσος, εξολόθρευση, σφαγές, πρόσφυγες, βάναυσα βασανιστήρια, βίαιες εκτοπίσεις, εχθρότητα, εξόντωση, περιφρόνηση, λιμοκτονία, κ.α. Αυτούς τους όρους, μεταξύ άλλων, χρησιμοποιεί στο άρθρο της με τίτλο «Ο Κουτσός Δήμαρχος της Κερασούντας», η Blanche Norton, Αμερικανίδα περιηγήτρια-ιατρός στην Τραπεζούντα, στην Κερασούντα, στην Κωνσταντινούπολη, στο Καραχισάρ και στο Μπουλανκτζάκ, για να περιγράψει την κατάσταση των Ελλήνων και των Αρμενίων της Μικρά Ασίας και του Πόντου, και όχι μόνο. «Όσον αφορά τους πρόσφυγες, τι μπορώ να πω γι’ αυτούς τους ανθρώπους που δεν έχει ήδη ειπωθεί, και ποιες λέξεις είναι αρκετά δυνατές για να τους ζωγραφίσουν στους Αμερικανούς, οι οποίοι ποτέ δεν έχουν δει πρόσφυγα; Πριν το πόλεμο η πόλης κατοικούταν από Έλληνες. Τώρα, υπάρχουν μόνο 200, οι περισσότεροι γυναίκες και παιδιά που επέστρεψαν μετά από μεγάλη περιπλάνηση. Στους δρόμους έβλεπα ομάδες θλιμμένων και ταλαιπωρημένων ανθρώπων, άστεγοι[...] » (Blanche Norton, 1922: 289-290) Η Αμερικανίδα ιατρός του Near East Relief, στο άρθρο της, που δημοσιεύτηκε στις 4 Απριλίου του 1822, καταγγέλλει και καταδικάζει για τον αφανισμό όλων των στοιχείων που δεν είναι Μουσουλμάνοι ή καθαροί Μουσουλμάνοι, όχι μόνο τους Τούρκους, αλλά «την ιμπεριαλιστική Βρετανία, την ιμπεριαλιστική Γαλλία, την ιμπεριαλιστική Ελλάδα και την αδιάφορη Αμερική.» Η Αγγλίδα περιηγήτρια-συγγραφέας, Dorina L. Neave στο έργο της «Είκοσι-Έξι Χρόνια στο Βόσπορο» (1933:174,179), υποστηρίζει ότι «Επικρατούσε ένα τρομερό καθεστώς τρομοκρατίας, μία τρομερή κατάσταση τρομοκρατίας [...] Η κυριαρχία της Τρομοκρατίας στην Τουρκία σκανδάλιζε και συγκλόνιζε ολόκληρο τον κόσμο […] θύμιζε την χειρότερη τρομοκρατία του Μεσαίωνα». Η δημοσιογράφος-περιηγήτρια Lady Dorothy Mills από την Άγκυρα γράφει: «Ο Τούρκος έχει αποδειχθεί ότι είναι ένας άνδρας πολέμου [...] έχοντας κερδίσει με πόλεμο μία χώρα, νομίζει ότι εκείνη μπορεί να διοικείται από μόνη της. Στην περίπτωση των Αρμενίων και των Ελλήνων, και άλλων εμπορικών λαών που έκαναν τόση μεγάλη ευημερία για την Τουρκία, ο Τούρκος ικανοποιήθηκε να τους πετάξει στη θάλασσα, αντί να χρησιμοποιήσει προς όφελός του για τα χαρίσματά τους και τις ικανότητές τους στο εμπόριο.»
Στο άρθρο αυτό αναλύονται αφενός τα νομικά ζητήματα που έχουν απασχολήσει τα Δικαστήρια κατά την ενοποίηση δημόσιων νομικών προσώπων με δημόσια νομικά πρόσωπα και αφετέρου τα διαφορετικής φύσεως νομικά ζητήματα που απασχόλησαν τα Δικαστήρια κατά την ενοποίηση ιδιωτικών νομικών προσώπων με δημόσιο νομικό πρόσωπο. Η διαφορετική φύση των ζητημάτων που ανέκυψαν οφείλεται στο διαφορετικό νομικό καθεστώς των ιδιωτικών νομικών προσώπων. Σχολιάζονται επίσης τα δύο εκ διαμέτρου αντίθετα πρακτικά επεξεργασίας του ΣτΕ, το 190/2006 επί αρχικού σχεδίου προεδρικού διατάγματος και στη συνέχεια το (Ολ.) 240/2006 επί του τροποποιηθέντος ιδίου σχεδίου προεδρικού διατάγματος καθώς και η 116/2008 απόφαση του Μονομελούς Πρωτοδικείου Αθηνών που έκρινε το κύρος της καταγγελίας των παραπάνω συλλογικών συμφωνιών. Τα πολιτικά και διοικητικά Δικαστήρια εκκινούν από διαφορετική αφετηρία και καταλήγουν σε εκ διαμέτρου αντίθετα συμπεράσματα. α) Το ΠΕ (Ολ.) ΣτΕ 240/2006 εκκινεί από τη σκέψη ότι στο άρθρο 22 παρ. 5 του Συντάγματος εμπίπτει η κύρια και η επικουρική κοινωνική ασφάλιση καθώς και η αναγνωριζόμενη ως ισοδύναμη με την επικουρική ασφάλιση σε ιδιωτικά νομικά πρόσωπα. Αντίθετα, το Μονομελές Πρωτοδικείο Αθηνών θεωρεί ότι από το πεδίο εφαρμογής του 22 παρ. 5 του Συντάγματος εξαιρείται η προαιρετική, ιδιωτική, επικουρική ασφάλιση που παρέχεται δυνάμει συλλογικών ενοχικών συμφωνιών μεταξύ εργοδοτών και εργαζομένων. β) Το ΣτΕ δεν ελέγχει αν πράγματι συντρέχουν λόγοι δημοσίου συμφέροντος για την ενοποίηση του ταμείου. Αντίθετα, το Μον. Πρωτοδικείο Αθηνών κάνει έναν εξαιρετικά αναλυτικό και εμπεριστατωμένο έλεγχο ως προς το ότι δεν αποτελεί σπουδαίο λόγο για την καταγγελία των εν λόγω συλλογικών συμβάσεων και συμφωνιών το αναφερόμενο στην αιτιολογική έκθεση του νόμου δημόσιο συμφέρον και συγκεκριμένα ο κίνδυνος να καταστούν τα πιστωτικά ιδρύματα μη βιώσιμα ή οριακά μη βιώσιμα μετά την τυχόν εμφάνιση των υποχρεώσεών τους προς τα ταμεία σύμφωνα με τα διεθνή λογιστικά πρότυπα. γ) Το ΣτΕ, μη ελέγχοντας τη συνδρομή των λόγων δημοσίου συμφέροντος, δεν ελέγχει ούτε την αναλογικότητα των περιορισμών των δικαιωμάτων των εν λόγω ταμείων και των ασφαλισμένων. Αντίθετα, το πολιτικό δικαστήριο κάνει σχετικές κρίσεις. Η απόφαση του Μον. Πρωτοδικείου Αθηνών είναι αιτιολογημένη ως προς το ότι δεν συντρέχουν οι λόγοι δημοσίου συμφέροντος που επικαλείται ο νομοθέτης όσον αφορά στη διασφάλιση της αξίας των μετοχών των συγκεκριμένων πιστωτικών ιδρυμάτων μετά την εφαρμογή των διεθνών λογιστικών προτύπων και ως προς το ότι οι περιορισμοί που εισάγονται είναι δυσανάλογοι με τον σκοπό που επιδιώκει ο νομοθετης. Ωστόσο, δεν εξετάζεται αν οι λοιποί λόγοι δημοσίου συμφέροντος τους οποίους επικαλείται η αιτιολογική έκθεση του νόμου συνιστούν σπουδαίο λόγο για την καταγγελία των εν λόγω συλλογικών συμβάσεων εργασίας και συμφωνιών. Απαιτείται αντίστοιχη τεκμηρίωση για τον σπουδαίο λόγο σε σχέση με τους λοιπούς λόγους δημοσίου συμφέροντος που αναφέρει η αιτιολογική έκθεση.
Το άρθρο καταλήγει ότι η νομοθεσία και η νομολογία δεν έχουν αξιοποιήσει τις αρχές του δικαίου της κοινωνικής ασφάλισης που θα μπορούσαν να συμβάλουν στη στη δικαστική αξιολόγηση του δημοσίου συμφέροντος και της αναλογικότητας των ενοποιήσεων. Οι ενοποιήσεις δεν είναι πανάκεια. Για να αρθούν οι ανισότητες και να επιτευχθούν οι στόχοι της δικαιότερης κατανομής του πλούτου μεταξύ των γενειών και μεταξύ των ασφαλισμένων απαιτείται ενοποίηση των καθεστώτων, όχι κατ’ ανάγκην των οργανισμών κοινωνικής ασφαλίσεως. Η κρατική παρέμβαση θα πρέπει να εστιάζει στον εξορθολογισμό της νομοθεσίας που διέπει τους ειδικούς ασφαλιστικούς οργανισμούς, τη σύγχρονη διοικητική οργάνωση και την υποστήριξη του έργου των ασφαλιστικών οργανισμών, έτσι ώστε η προσφυγή στις ενοποιήσεις να μην υποδηλώνει αδυναμία συντονισμού και ελέγχου.
This theoretical paper presents and discusses recent research findings on victimization in childhood as assessed by children themselves and by peers. The two sources of information are found to yield four categories of victims: true victims, self-identified victims (or "paranoids", or "sensitives"), peer-identified victims (or "deniers", or "defensives"), and non victims. Discussion focuses on the different characteristics of these categories of victims, on age and gender differences, as well as on the implications of the existing research data for prevention and intervention.
Στο άρθρο αυτό παρουσιάζονται ερευνητικά αποτελέσματα που αφορούν τη χρήση ειδικού υπολογιστικού εργαλείου δυναμικού χειρισμού γεωμετρικών μεγεθών στο πλαίσιο του πειραματισμού 13χρονων μαθητών για την αυξομείωση γεωμετρικών κατασκευών με βάση σχέσεις αναλογίας μεταξύ μεταβλητών μεγεθών. Τα παιδιά εργάστηκαν σε ομάδες στο εργαστήριο υπολογιστών του σχολείου τους χρησιμοποιώντας ειδικά σχεδιασμένα υπολογιστικά εργαλεία συμβολικής και γραφικής αναπαράστασης των μεταβλητών μεγεθών, που παράλληλα μπορούσαν να τα χειριστούν ελέγχοντας με δυναμικό τρόπο την αριθμητική μεταβολή τους. Η ανάλυση εστιάζεται στα σχήματα που αναδύθηκαν κατά τη χρήση του εργαλείου δυναμικού χειρισμού αλλά και στις μεταξύ τους διασυνδέσεις. Στα ευρήματα καταγράφεται η αξιοποίηση του δυναμικού χειρισμού ως πλαισίου αναγνώρισης και έκφρασης συσχετίσεων μεταξύ των μεταβλητών μεγεθών μιας γεωμετρικής κατασκευής με στόχο την αυξομείωσή της στο πλαίσιο κατάλληλα σχεδιασμένων δραστηριοτήτων.
Cette étude fut élaborée dans le cadre d’une bourse de recherche du gouvernement canadien (Canadian Studies Faculty Enrichment Award) et s’appuie sur un matériel récolté dans divers centres de recherche (Bibliothèque nationale du Québec à Montréal, Bibliothèque des sciences humaines et sociales de l’université Laval, Centre de documentation de la Centrale de l’enseignement du Québec) et organismes québécois (Centre de documentation et Coordination à la condition féminine au ministère de l’Éducation, du Loisir et du Sport). La recherche ambitionne de combler un vide historiographique : au Québec, une des régions les plus progressistes de la francophonie en matière d’égalité des sexes et de parité, le champ d’investigation des représentations des sexes et du genre dans les manuels scolaires du secondaire est encore inexploré.L’étude porte plus précisément sur les manuels d’histoire des deux dernières classes de l’enseignement secondaire en usage entre 1980 et 2004. Pourquoi des manuels du second cycle du secondaire ? Dépourvus des stéréotypes trop voyants rencontrés parfois dans les manuels de l’école primaire, ils se prêtent plus facilement à l’analyse. Pourquoi des manuels si récents ? Compte tenu de la mission civique dont ils sont investis, l’examen de ces ouvrages permet d’interroger un avenir en train de s’inventer. La démarche méthodologique adoptée est à la fois quantitative et qualitative : constituer un corpus de notations sexuées afin d’examiner la place de chaque sexe dans l’histoire scolaire québécoise ; comparative également : il s’agit de mettre en évidence tant les évolutions advenues au cours de vingt-cinq ans que les lignes de force communes et les disparités entre manuels.Deux axes se profilent : l’examen des sources imprimées (programmes d’études, manuels) qui révèle un certain progrès de la place accordée au sexe féminin dans l’espace historique ; la proposition d’une relecture de deux périodes historiques fondée sur les apports des spécialistes de l’histoire des femmes et du genre, afin de repérer les vides laissés dans le récit historique : il s’agit des XVIIe et XVIIIe siècles (étude de l’histoire de la colonie française de la Nouvelle-France) d’une part, de la période de l’entre-deux-guerres (étude de l’histoire de France), d’autre part. L’étude des chapitres correspondants des manuels québécois révèle que l’action des individus est largement mesurée à l’aune des structures du pouvoir interprétées au masculin ; les femmes, n’étant pas toujours concernées par cet aspect de l’histoire, restent souvent invisibles.
The purpose of this study was to evaluate the histologic changes that occur between 3 and 12 weeks in an intra-articular, semitendinosus autograft, which was harvested without detachment of its tibial insertion and was placed through tibial and femoral drill holes, in a rabbit model. About 30 New Zealand white rabbits underwent ACL replacement using a semitendinosus tendon autograft. The normal ACL was transected at its femoral and tibial insertions. The tendon graft was harvested without detachment of its tibial insertion and its free end was secured with sutures. The graft was then passed through one tibial and one femoral tunnel and secured at the lateral femoral condyle. All animals were divided into three groups and were killed at 3, 6 and 12 weeks after surgery. Nine more animals underwent ACL reconstruction using a free semitendinosus tendon autograft. These animals were used as controls. The intra-articular portion of the graft and the interface between the bone tunnel and the graft was evaluated postoperatively for gross morphology and histological appearance. Results of this study showed that in a rabbit model the semitendinosus tendon autograft retained its viability when harvested without detachment of its peripheral insertion. On contrary, at the control group, necrosis of the graft was observed 3 weeks after surgery and progressively revascularization and maturation occurred 6 and 12 weeks after surgery. Retaining the tibial insertion of the semitendinosus autograft seems to preserves its viability and bypasses the stages of avascular necrosis and revascularization that occurs with the use of a free tendon autograft.
Kyparissiakos Gulf forms a 45 km long zone located at 70-80 km east from the Hellenic trench with a general direction NNW-SSE. Onshore studies show the existence of several neotectonic horsts and grabens bounded by E-W trending normal faults. Thrust sheets of the underlying Hellenides crop out within the horst areas and younger sediments, mostly Lower Pleistocene, have been deposited in the grabens. The age of the marine sediments is mostly Lower Pleistocene. Throw rate on the normal faults varies between 0.7 and >1.0 mm/yr, accommodating extension in the N-S direction. Subsidence rates during Early Pleistocene are between 0.1 and 0.3 mm/yr, whereas uplift rates during Middle Pleistocene-Present are between 0.18 and 0.50 mm/yr. Offshore data were obtained using bathymetric and air-gun litho-seismic profiles. The shelf has been disrupted by active faults with several meters of throw. Average Holocene throw rates are 0.4-0.6 mm/yr, but in some areas adjacent Filiatra and Olympia values greater than 3 mm/yr are detected. Holocene and Upper Pleistocene marine sediments thicken gradually to the north, as do the marine Lower Pleistocene sediments onshore. A NNW-SSE offshore longitudinal fault parallel to the Kyparissiakos coast with throw rate above 3 mm/yr is the dividing structure between the uplifted coastal area and the present-day gulf. This indicates a major change in paleogeography between Early and Middle Pleistocene. Present-day transition from E-W compression in the Hellenic Trench to E-W extension in the Kyparissiakos Gulf and to N-S extension in Western Peloponnesus is discussed. The development of E-W structures in Western Peloponnesus since Latest Pliocene may be related to the Central Hellenic Shear Zone, which accommodates differential GPS rates between Northern Greece and Southern Peloponnesus.
Background: The prognostic significance of age in ovarian cancer has not been clarified. We investigated the characteristics of ovarian cancer presenting in ages >70 years and assessed the prognostic significance of advanced age. Patients and Methods: Four hundred and fifty-three patients with stage IIC-IV ovarian cancer (age>70 years n=106 [23%]), treated postoperatively with platinum-based chemotherapy were retrospectively reviewed. Results: Median overall survival (OS) of patients ≤70 years old (52.3 months, 95% CI: 43.2-61.3) was longer than that of older patients (38.8 months, 95% CI: 29.9-47.7) (p=0.005), but this difference was not significant in a multivariate analysis (p=0.978). Age >70 years was correlated with worse performance status (PS) (p=0.019), higher tumor grade (p=0.033), residual disease >2 cm (p=0.006) and less frequent paclitaxel administration (p<0.001). Toxicity from chemotherapy was similar between the two age groups, but the relative dose intensity of paclitaxel was lower among elderly patients. Conclusion: The worse outcome of ovarian cancer in elderly patients may be attributed to other associated adverse prognostic factors, but advanced age was not an independent prognostic factor.
Three advanced models of pharmacokinetics are described. In the first class are physiologically based pharmacokinetic models based on in vitro data on transport and metabolism. The information is translated as transporter and enzyme activities and their attendant heterogeneities into liver and intestine models. Second are circulatory models based on transit time distribution and plasma concentration time curves. The third are fractal models for nonhomogeneous systems and non-Fickian processes are presented. The usefulness of these pharmacokinetic models, with examples, is compared.
BACKGROUND AND OBJECTIVES: The Procleix Ultrio human immunodeficiency virus type 1 (HIV-1)/hepatitis C virus (HCV)/hepatitis B virus (HBV) (Ultrio) assay simultaneously detects HIV-1 RNA, HCV RNA and HBV DNA in individual blood donations. The main objective of the study was to assess the analytical and clinical sensitivity of the multiplex and discriminatory probe assays in samples with a low viral load. MATERIAL AND METHODS: The VQC HIV RNA genotype B, HCV RNA genotype 1 and HBV DNA genotype A standard dilutions were tested in 26 repeats. The probability of detection by Ultrio was compared with previously obtained data of the Procleix Duplex HIV-1/HCV assay on the same reference panels. A selection of 121 anti-HIV-1, 138 anti-HCV and 190 HBsAg positive samples from patients receiving antiviral therapy were tested. The majority of patient samples had a viral load below the detection limit of the diagnostic nucleic acid test assays, which made them suitable to evaluate the performance of the multiplex and discriminatory assays on yield cases with a similar low viral load. RESULTS: The 95% and 50% detection end-points of the Ultrio assay along with the corresponding 95% confidence intervals are 53.7 (32.9-117.2) and 8.6 (6.2-12.1) geq/ml for HIV-1 RNA, 30.3 (19.0-62.4) and 5.2 (3.7-7.2) geq/ml for HCV RNA and 393.7 (147.9-6978) and 54.5 (22.4-143.8) geq/ml for HBV DNA. The analytical sensitivity of Ultrio expressed as a potency factor relative to previously obtained Duplex results on the same HIV-1 RNA and HCV-RNA standard dilutions was 1.09 (0.20-6.10) and 1.11 (0.21-5.89), respectively. The assay detected all 22 HIV-1 infected patients with viral load > 50 copies/ml, and 41 of 99 patients (41%) with viral load < 50 copies/ml, of which 23 (56%) were detected by the discriminatory assay. All 47 patients with HCV RNA load > 521 IU/ml and 10/91 polymerase chain reaction-negative patients with viral load < 50 IU/ml tested positive in Ultrio assay of which five were missed in the discriminatory test. The assay detected 53/55 HBV infected patients (96%) with viral load > 250 copies/ml and 108/135 patients (80%) with viral load < 250 copies/ml of which 17 (16%) were missed by the discriminatory test. CONCLUSIONS: The new Procleix Ultrio assay is as sensitive as the Procleix Duplex assay for HIV-1 and HCV detection meeting the requirements of universal guidelines. The ability of the assay to detect HBV DNA in low viral load samples could be useful for screening blood. Inevitable negative results of discriminatory probe assays caused by stochastic sample variation will reduce the chance of recognizing low viraemic blood donors detected by individual donation nucleic acid test.
A democratic European Turkey, that endorses the acquis communautaire and the European political culture as that has evolved over the last 50 years is not considered by Greece as a security threat. However, certain forms of conduct on the part of our neighbor and NATO ally cause serious concern to Athens and the Greek people, which determines the approach of the Greek government towards Greek-Turkish relations.
Purpose of investigation: Uterine sarcomas are rare neoplasms characterized by a high rate of local recurrences and distant metastases. The role of chemotherapy in early-stage completely resected disease remains controversial. Methods: Thirty-one patients with Stage I or II uterine sarcomas, referred to our center for adjuvant chemotherapy, received anthracycline-based regimens. Seventeen (54.8%) patients received ifosfamide, etoposide and epirubicin, six (19.4%) were treated with doxorubicin and carboplatin, three (9.6%) were administered doxorubicin and ifosfamide, while five (16.1%) patients received various anthracycline-based regimens. Results: With a median follow-up of 82 months disease recurred in 12 (38.7%) patients. Five-year survival probability is estimated at 54%. Both median overall survival and time to progression for all patients have not been reached yet. Patients who received ifosfamide-containing regimens had a statistically significant benefit in overall survival (p ≤ 0.05) when compared with those treated with non-ifosfamide-containing regimens. Conclusion: Our data suggest a potential role for anthracycline- and ifosfamide-containing chemotherapy in the adjuvant setting for early-stage uterine sarcomas.
Respiratory infections by bacteria and viruses often trigger symptoms of asthma in both adults and children. This observation and subsequent mechanistic studies have demonstrated important interactions among allergens, microbes and the atopic host. The mechanisms responsible for microbe-induced asthma exacerbations are only incompletely understood. A focal point of current research is the inflammatory response of the host following an encounter with a pathogenic microbe, including variations in chemokine and cytokine production and resulting in changes in bronchial hyper-responsiveness and lung function. Direct bronchial infection, exposure of nerves with resulting neurogenic inflammation and a deviated host immune response are among the mechanisms underlying these functional disorders. Lately, suboptimal innate immune responses, expressed as defective interferon production, have gained attention as they might be amenable to intervention. This review describes the suggested mechanisms involved in the complex interactions between 'asthmagenic' microbes, the immune system and atopy, based on in-vitro and in-vivo experimental models and epidemiological evidence. In addition, it provides a synopsis of potential therapeutic strategies either directly against the microorganisms or in respect to the associated inflammation.
Aim. This study examined the ventilatory responses and blood lactate concentration after a simulated synchronized swimming routine of athletes of two different age categories. Methods. Sixteen trained female synchronized swimmers, 8 competing at the comen category (age: 13.8±0.2 years) and 8 competing at the senior category (age: 22.6±0.9 years), performed a maximal 400 m swimming test and a simulated synchronized swimming routine. Oxygen uptake (V̇O2) of the tests was obtained by backward extrapolation of a monoexponential curve fitted to the postexercise oxygen uptake data. Results. There were no differences in V̇O2 at the end of the routine (37.4±2.7 vs 40.5±2 mL·kg -1·min-1, or 81.8±3.1% and 85.8±2.7% of V̇O2peak) and blood lactate (5.7*0.9 vs 4.5±0.4 mmol-L-1) between senior and comen synchronized swimmers. There was no difference in the half-time of V̇O2 decay (T1/2) between the athletes of the two categories, but T1/2 was significantly higher after the routine compared with the V̇O2peak test for both categories (senior: 45.2±5.9 vs 33.1±2.1 s, P<0.05, comen: 38.2±6 vs 27.4±8.2 s, P<0.05). The mean end-tidal pressure of CO2 during the second half of the recovery was higher after the routine than after the V̇O2peak test (37.2±1.4 vs 34.5±1.5 mmHg, P<0.05), possibly due to the prolonged periods of breath holding (55±4% of routine time). Breathing frequency was also high (30±2.2 breaths.min-1) at the later part of recovery after the routine. Conclusion. Cardiorespiratory and metabolic responses to a simulated synchronized swimming routine were similar in senior and comen athletes. The slower recovery of V̇O2 after the routine could be related to the elevated cost of ventilation, especially during the later stages of recovery, possibly as a result of the prolonged apnea.
Aim. This study examined the ventilatory responses and blood lactate concentration after a simulated synchronized swimming routine of athletes of two different age categories. Methods. Sixteen trained female synchronized swimmers, 8 competing at the comen category (age: 13.8±0.2 years) and 8 competing at the senior category (age: 22.6±0.9 years), performed a maximal 400 m swimming test and a simulated synchronized swimming routine. Oxygen uptake (V̇O2) of the tests was obtained by backward extrapolation of a monoexponential curve fitted to the postexercise oxygen uptake data. Results. There were no differences in V̇O2 at the end of the routine (37.4±2.7 vs 40.5±2 mL·kg -1·min-1, or 81.8±3.1% and 85.8±2.7% of V̇O2peak) and blood lactate (5.7*0.9 vs 4.5±0.4 mmol-L-1) between senior and comen synchronized swimmers. There was no difference in the half-time of V̇O2 decay (T1/2) between the athletes of the two categories, but T1/2 was significantly higher after the routine compared with the V̇O2peak test for both categories (senior: 45.2±5.9 vs 33.1±2.1 s, P<0.05, comen: 38.2±6 vs 27.4±8.2 s, P<0.05). The mean end-tidal pressure of CO2 during the second half of the recovery was higher after the routine than after the V̇O2peak test (37.2±1.4 vs 34.5±1.5 mmHg, P<0.05), possibly due to the prolonged periods of breath holding (55±4% of routine time). Breathing frequency was also high (30±2.2 breaths.min-1) at the later part of recovery after the routine. Conclusion. Cardiorespiratory and metabolic responses to a simulated synchronized swimming routine were similar in senior and comen athletes. The slower recovery of V̇O2 after the routine could be related to the elevated cost of ventilation, especially during the later stages of recovery, possibly as a result of the prolonged apnea.
Aim. This study examined the ventilatory responses and blood lactate concentration after a simulated synchronized swimming routine of athletes of two different age categories. Methods. Sixteen trained female synchronized swimmers, 8 competing at the comen category (age: 13.8±0.2 years) and 8 competing at the senior category (age: 22.6±0.9 years), performed a maximal 400 m swimming test and a simulated synchronized swimming routine. Oxygen uptake (V̇O2) of the tests was obtained by backward extrapolation of a monoexponential curve fitted to the postexercise oxygen uptake data. Results. There were no differences in V̇O2 at the end of the routine (37.4±2.7 vs 40.5±2 mL·kg -1·min-1, or 81.8±3.1% and 85.8±2.7% of V̇O2peak) and blood lactate (5.7*0.9 vs 4.5±0.4 mmol-L-1) between senior and comen synchronized swimmers. There was no difference in the half-time of V̇O2 decay (T1/2) between the athletes of the two categories, but T1/2 was significantly higher after the routine compared with the V̇O2peak test for both categories (senior: 45.2±5.9 vs 33.1±2.1 s, P<0.05, comen: 38.2±6 vs 27.4±8.2 s, P<0.05). The mean end-tidal pressure of CO2 during the second half of the recovery was higher after the routine than after the V̇O2peak test (37.2±1.4 vs 34.5±1.5 mmHg, P<0.05), possibly due to the prolonged periods of breath holding (55±4% of routine time). Breathing frequency was also high (30±2.2 breaths.min-1) at the later part of recovery after the routine. Conclusion. Cardiorespiratory and metabolic responses to a simulated synchronized swimming routine were similar in senior and comen athletes. The slower recovery of V̇O2 after the routine could be related to the elevated cost of ventilation, especially during the later stages of recovery, possibly as a result of the prolonged apnea.
Human rhinoviruses (RVs) are responsible for the majority of upper respiratory tract infections. Despite the high prevalence, the pathogenesis is incompletely understood. Experimental models would permit study of the immunological response to infections. Animal models have many limitations because of the anatomic and physiological differences between mammalian species. The only nonhuman animals susceptible to RV are chimpanzees and gibbons. Mouse models are not used because of host cell tropism of RV. This problem may have been partially overcome by transfecting mouse cells with viral RNA, by replacing mouse ICAM-1 with the human counterpart and by using a variant virus. It remains to be seen if these advances will translate into establishment of useful mouse models. In the absence of animal models, epithelial cell lines such as BEAS-2B, A549, 16HBE and HEp-2 have been used. Fibroblasts and smooth muscle cells have also been used. Although transformed cell lines have many properties in common with normal epithelial cells, they lose certain differentiated functions. Therefore, primary and recently well-differentiated cultures are used to study the immune response. In addition to a local inflammatory response, a systemic immune response to RV does develop; therefore peripheral blood mononuclear cells and dendritic cells have been infected with RV, shedding additional light on cell-mediated immunity. Cellular models are invaluable investigational tools for understanding mechanisms of RV-induced asthma and evaluating new targets for therapy.
The purpose of this study was to use quantitative methods to measure the size and shape of the sella turcica and thus establish normative reference standards that could assist in a more objective evaluation and detection of pathological conditions. Standardized lateral cephalograms of 184 healthy Greeks (91 males and 93 females) were used. The age range was between 6 and 17 years. Conventional measurements included three different heights of the sella turcica (anterior, posterior, median), its length, and width, measured in relation to the Frankfort reference line. In addition, the area of sella turcica was calculated. Morphometric methods were used to assess shape. The tracings were superimposed using the Procrustes method, and the average shape was computed. Principal component analysis (PCA) was used to assess shape variability. The data were correlated with centroid size, age, and gender. Unpaired t-tests were used to determine gender differences. Sella height anteriorly was the only variable found to be significantly different between the genders, being larger in females by 0.5 mm. Linear and area measurements were found to be significantly correlated with age, but all correlations were low (r(2) below 8 per cent). Sella turcica shape, as described by PCA, was different between males and females, mainly at the posterior aspect of the sella outline. However, although there was an extensive overlap between the genders, and differences were minimal. Age was not found to be correlated with the shape coefficients, although, in the female group, the first principal component of shape was marginally not significant. Allometry was observed in both genders, the sella showing a tendency towards a flatter and wider shape with increase in size. The results of this study constitute quantitative reference data that could be used for objective evaluation of sella shape.
The present work describes the interfacial polymerization of aniline in the absence or presence of surfactants. Polyaniline was readily obtained in the semi-oxidized doped state and was cast from the aqueous phase. The structural and morphological characteristics of the polyanilines were deduced from X-ray Diffractometry and Scanning Electron Microscopy. Various morphologies were obtained depending on the surfactant addition. Conductivity measurements recorded for HCl doped polyaniline nanoneedles from 5 to 330 K showed a T, value at 230 K, where their transport behaviour changes from metallic-like above T, to semiconductive below T,. Furthermore, extensive magnetic measurements have been performed as a function of applied field and temperature. (c) 2007 Elsevier Ltd. All rights reserved.
OBJECTIVE: Adiponectin plays a protective role in several malignancies, including myeloblastic leukemia, whereas leptin may increase the proliferation of progenitor cells and may stimulate leukemic cell growth in vitro. We investigated the role of adiponectin and leptin levels in the etiopathogenesis of myelodysplastic syndromes (MDS), a preleukemic condition with increasing incidence which has recently been associated with obesity.
METHODS: In a case-control study, 101 cases with incident, histologically confirmed primary MDS and 101 controls matched on gender and age were studied between 2004 and 2007, and blood samples were collected.
RESULTS: Higher serum adiponectin levels were associated with lower risk of MDS by bivariate analysis and after adjusting for age, gender, body mass index and serum levels of leptin (p < 0.001). Subjects in the third quartile for leptin levels had a lower risk of MDS than controls, and low leptin concentrations were observed in low-risk MDS patients with normal or good prognostic karyotype after adjusting for age, gender and body mass index.
CONCLUSIONS: Circulating adiponectin and leptin may play an important role in MDS etiopathogenesis. Future studies are needed to confirm these associations and to explore underlying mechanisms.
{OBJECTIVE: To determine circulating levels of adiponectin in preterm infants and examine possible associations with anthropometric measurements, weight gain, and leptin and insulin levels. DESIGN: Prospective study. SETTING: A university hospital neonatal care unit. Study population: 62 preterm (mean (SD) gestational age 32.0 (2.1) weeks) and 15 full-term infants (reference group). INTERVENTIONS: Blood samples taken at discharge (40.9 (14.8) days of life) from the preterm infants and at a comparable postnatal age in full-term infants. All infants were fed the same commercial formula, but in nine preterms the formula contained long-chain polyunsaturated fatty acids (LCPUFAs). MAIN OUTCOME MEASURES: Serum levels of adiponectin, leptin and insulin. Associations of adiponectin levels were tested only in the preterm group. RESULTS: Serum levels of adiponectin were lower in preterm (40.9 (14.8) microg/ml) than full-term infants (53.1 (16.0) microg/ml, p<0.01). However, after adjustment for body weight, the influence of prematurity on adiponectin levels was no longer significant. In preterm infants, adiponectin levels independently correlated with being born small for gestational age (SGA) (beta=-0.35
Καμπερίδου, Ε. (2007). Ένα είδος Φυλετικού Διαχωρισμού» (Pardoe, 1837) στους υποτελείς λαούς της Οθωμανικής Αυτοκρατορίας: οι επιβαλλόμενες φυλετικο-χρωματικές διακρίσεις στις οικίες, στα ενδύματα και στα υποδήματα των υποτελών λαών. Φιλοσοφία & Παιδεία, 44-45, 22-25. J.4 in APELLA
Concurrent chemoradiotherapy has become a standard therapy for locoregionally advanced inoperable non-small cell lung cancer (NSCLC). The purpose of this phase II trial was to evaluate the efficacy and toxicity of concurrent chemoradiotherapy following induction with non-platinum chemotherapy in patients with inoperable locally advanced NSCLC. Patients and Methods: All patients with locally advanced inoperable NSCLC ECOG performance status (PS): 0-1 following staging received paclitaxel 200 mg/m2 in a 3-h infusion on day 1 and gemcitabine 1000 mg/m2 on days 1 and 8 every 21 days for two cycles. The patients with a response or stable disease (SD) continued to receive paclitaxel 60 mg/m2 weekly and radiotherapy 63 Gy given at 1.8 Gy once a day for 7 weeks. Results: Forty-three eligible patients entered the study. The median age was 63 years (range 42-76), male 93%, IIIB 63% and IIIA 37%. Following induction 15 (36.5%) of the patients responded: complete response (CR), 2%; partial response (PR), 33%; and 19 (46.5%) SD. From those with SD, 7 (37%) improved to a PR following concurrent chemoradiotherapy. With a median follow-up of 44 months (95% CI: range 36-53) the median survival was 20.8 months (95%c CI: range 15.4-26.3) and time-to-progression 8.4 months (95% CI: range 6.2-10.6). The median survival of those who had improved response from SD to PR was 31.4 months (95% CI: range 18.7-44.1) versus 20.8 months (95% CI: range 5.5-11.3) for those who had no improvement (p=0.20). The commonest grade 3/4 toxicity in induction was neutropenia 12% with 2 febrile neutropenic patients whereas in the concurrent chemoradiotherapy neutropenia, neurotoxicity and oesophagitis were observed in 6% of the patients. Conclusion: Concurrent chemoradiotherapy following induction chemotherapy in patients with stage III NSCLC is feasible with reasonable efficacy and acceptable toxicity.
Most recent molecular studies revealed the phylogeny of Greek Podarcis species, which for years remained elusive, due to discordant data produced from various chromosomal, complement fixation and protein studies. In this report, we analyzed cellular immune responses of spleen derived lymphocytes from six allopatric Podarcis species encountered in Greece, by assessing two-way mixed lymphocyte reaction (MLR)-induced proliferation. On the basis of stimulation indices (S.I.) as determined from cultures set up from xenogeneic splenocytes coincubated in pairs, we generated a phylogenetic tree, fully consistent with the phylogenetic relationships of Podarcis as determined by parallel analyses basedon partial mitochondrial (mt) DNA sequences. Although the exact mechanisms triggering lymphocyte responses in lizard two-way xenogeneic MLR are not fully understood, our results show the potential use of cell-mediated immune responses as an additional approach to mtDNA analysis, for species delimitation within specific lizard taxa.
Sarajedini A, Spurzem R, Cannon R, Castellani V, Cudworth K, Da Costa G, Deng LC, Giersz M, Hatzidimitriou D, Lada C. Commission 37: Star Clusters. [Internet]. 2007;26A:277 - 277. WebsiteAbstract
During the period 2004 to 2005, the following symposia and colloquia were related to the activities of the commission: The A-Star Puzzle (IAUS224), Massive Star Birth: A Crossroads of Astrophysics (IAUS227), and From Lithium to Uranium: Elemental Tracers of Early Cosmic Evolution (IAUS228).
The Commission business meeting was held on 17 August 2006. Approximately 20 people attended, including the Commission vice-president, Rainer Spurzem. The sole member of the Commission Organizing Committee that was present was Gary Da Costa, who, along with Patricia Whitelock, the outgoing president of Division VII and Commission 33, served as chairs of the meeting.
In the current paper are presented the results of a multidisciplinary study (stratigraphical, sedimentological, geophysical and geochemical) combined with modern techniques (G.I.S. and remote sensing). This study aims at integrating the natural and anthropogenic factors affecting the Korissia lagoon. It is a shallow coastal lagoon, communicating with the sea via an artificial channel. The area around the lagoon consists of alluvial sediments hosting, in places, newly formed and/or “old” (pre – Holocene) sand-dunes. The broader area constitutes a post- alpine sedimentary basin characterised by smooth morphological relief. The lower stratigraphic unit of the post-alpine sequence is a Pleistocene marly formation, which was detected as the basement (5-15 hm.m) by the geophysical survey. The resistivity-based basement map implies the existence of a “palaeo-gulf” trending E- W. These marls constitute the impermeable basement of a shallow aquifer hosted in the area. The salinity of the lagoon is very high during summer (>40psu) but it does not affect significantly the wells around it. The lagoon is well oxygenated, while the wells have lower D.O. values. Ammonia and nitrates are the main inorganic Nitrogen forms, in the lagoon and the wells, respectively. Phosphorus is the limiting factor for phytoplankton growth. Human activities affect the area that is in need of an environmental management plan in order to prevent ecological degradation.
In the current paper are presented the results of a multidisciplinary study (stratigraphical, sedimentological, geophysical and geochemical) combined with modern techniques (G.I.S. and remote sensing). This study aims at integrating the natural and anthropogenic factors affecting the Korissia lagoon. It is a shallow coastal lagoon, communicating with the sea via an artificial channel. The area around the lagoon consists of alluvial sediments hosting, in places, newly formed and/or “old” (pre – Holocene) sand-dunes. The broader area constitutes a postalpine sedimentary basin characterised by smooth morphological relief. The lower stratigraphic unit of the post-alpine sequence is a Pleistocene marly formation, which was detected as the basement (5-15 Οhm.m) by the geophysical survey. The resistivity-based basement map implies the existence of a “palaeo-gulf” trending EW. These marls constitute the impermeable basement of a shallow aquifer hosted in the area. The salinity of the lagoon is very high during summer (>40psu) but it does not affect significantly the wells around it. The lagoon is well oxygenated, while the wells have lower D.O. values. Ammonia and nitrates are the main inorganic Nitrogen forms, in the lagoon and the wells, respectively. Phosphorus is the limiting factor for phytoplankton growth. Human activities affect the area that is in need of an environmental management plan in order to prevent ecological degradation.
The Author list was incomplete in ATel#1152. On 2007 July 21.46 UT a spectrum of the nova candidate M31N 2007-07c (see ATel#1146, ATel#1149) was obtained with Double-Beam Spectrograph on the Palomar Hale-5m telescope. The 400/6000 grism (3.5 angstrom FWHM) and 158/7500 grating (8.6 angstrom FWHM) were used with 1200s exposure, each. The H-alpha line displays a P-Cygni profile. The measured expansion velocity is -1630+/-20 km/ sec (blue shifted), based on measurements of the Ca H+K lines, the G Band, H-beta, Mg lines and the near-infrared Ca-triplet.
The purpose of the present study was to describe the development and validation of the Self-Talk Questionnaire (S-TQ), designed to measure two functions of self-talk strategies, namely the motivational function and the cognitive function, used by athletes to enhance their sport performances. The study was conducted in three phases. The first phase targeted item selection and content relevance. The second phase set out to test the factor structure of the instrument. The aim of the third phase was focused on further examination of the psychometric properties of the instrument. The results of an exploratory factor analysis provided adequate support for the instrument. The S-TQ consists of 11 items, representing two factors (motivational and cognitive). A confirmatory factor analysis showed an acceptable fit to the data. The factors were internally consistent, the correlations with external criteria were significant, and test-retest reliability values were very good. Examining the relationships between the S-TQ and similar constructs supported convergent validity. Discriminant validity was supported by correlations between the S-TQ and a different construct. The S-TQ appears to be a promising psychometric instrument that can be used in research and psychological intervention programs.
This paper is based on the research on the possible structure of an information system for the purposes of occupational health and safety management. We initiated a questionnaire in order to find the possible interest on the part of potential users in the subject of occupational health and safety. The depiction of the potential interest is vital both for the software analysis cycle and development according to previous models. The evaluation of the results tends to create pilot applications among different enterprises. Documentation and process improvements ascertained quality of services, operational support, occupational health and safety advice are the basics of the above applications. Communication and codified information among intersted parts is the other target of the survey regarding health issues. Computer networks can offer such services. The network will consist of certain nodes responsible to inform executives on Occupational Health and Safety. A web database has been installed for inserting and searching documents. The submission of files to a server and the answers to questionnaires through the web help the experts to perform their activities. Based on the requirements of enterprises we have constructed a web file server. We submit files so that users can retrieve the files which they need. The access is limited to authorized users. Digital watermarks authenticate and protect digital objects.
Alzheimer's disease (AD) is increasing in prevalence. There are no known preventive or curative measures. There is evidence that oxidative stress, homo-cysteine-related vitamins, fats, and alcohol have a role in the pathogenesis of AD. Some epidemiologic studies suggest that higher dietary intake of antioxidants, vitamins B(6), B(12), and folate, unsaturated fatty acids, and fish are related to a lower risk of AD, but reports are inconsistent. Modest to moderate alcohol intake, particularly wine, may be related to a lower risk of AD. The Mediterranean diet may also be related to lower AD risk. However, randomized clinical trials of supplements of vitamins E, B(12), B(6), and folate have shown no cognitive benefit, and randomized trials for other nutrients or diets in AD are not available. The existing evidence does not support the recommendation of specific supplements, foods, or diets for the prevention of AD.
The aim of the present study was to investigate whether replacement of broad-spectrum cephalosporins (CEPs) by piperacillin/tazobactam (TZP) as first-line empirical therapy may have an effect on beta-lactam resistance among Klebsiella pneumoniae and Escherichia coli in a tertiary care hospital. Data regarding CEP and TZP consumption and resistance were collected on a bimonthly basis during an open-label 2-year (1 year observational and 1 year interventional) study. Consumption of ceftazidime was reduced by 64.5%. In contrast, consumption of the other third-generation CEPs (cefotaxime and ceftriaxone) remained almost stable, whereas an increase in consumption of TZP by 2.8-fold was observed. A significant decrease in resistance to third-generation cephalosporins among K. pneumoniae isolates was observed, and the incidence of extended-spectrum beta-lactamase-producing isolates was notably reduced. These findings were less evident among E. coli isolates. Despite the significant increase in TZP consumption, the respective resistance rates of both bacterial species examined have remained almost unchanged.
The evolution of imipenem disk-diffusion susceptibility results of 2652 strains of Klebsiella pneumoniae and 7596 Escherichia coli isolated during the period 2000-2005 were analysed. Screening for production of metallo-beta-lactamases was performed using the EDTA-synergy method. The percentage rate of K. pneumoniae isolates having a zone diameter < or =25 mm increased from 20% in 2000 to 41% in 2005, whereas the respective rate of isolates having a zone diameter > or =30 mm decreased from 48 to 23%. These changes were more evident during 2000-2002, followed in 2003 by the isolation of the first imipenem-resistant strains. Regarding E. coli, a similar decrease was observed (the rates of isolates having a zone diameter < or =25 mm and > or =30 mm changed from 7% and 68% in 2000, to 32% and 36% in 2005, respectively) following the respective changes of K. pneumoniae. A total of 20 K. pneumoniae strains, but no E. coli, were confirmed as metallo-beta-lactamase producers. In conclusion, a decrease of the imipenem susceptibility prior to the isolation of the first resistant strains in a tertiary care hospital was detected, as well as differences in this decrease between the two species. These findings indicate that monitoring of the evolution of imipenem susceptibility in real-time may help in unveiling forthcoming resistance and in implementing the appropriate diagnostic techniques.
Temperature sensitivity of digestive processes has important ramifications for digestive performance in ectothermic vertebrates. We conducted a comparative analysis of temperature effects on digestive processes [gut passage times (GPTs) and apparent digestive efficiencies (ADEs)] in five lacertid lizards occurring in insular ( Podarcis erhardii, P. gaigeae ), and mainland ( P. muralis, P. peloponnesiaca, Lacerta graeca ) Mediterranean environments. GPTs were negatively correlated to temperature with mainland taxa having 10–20% longer GPTs than island taxa. In contrast to previous studies that estimate ADEs using bomb calorimetry, we compare ADEs by analyzing discrete efficiencies for lipids, sugars and proteins at three temperature regimes (20, 25, and 30°C); each of these categories produces different results. ADEs for lipids and sugars showed a monotonic increase with temperature whereas ADEs for proteins decreased with temperature. Island taxa had consistently higher ADEs than their mainland counterparts for lipids and for proteins but not for sugars. They are characterized by superior energy acquisition abilities despite significantly shorter GPTs. Their increased digestive performance relative to the mainland species appears to allow them to maximize energy acquisition in unproductive island environments where food availability is spatially and seasonally clustered.
A 44-year old male patient with a past medical history of a complete surgical excision of pelvic hydatid cyst two years previously presented with constant pelvic floor pain and plasma IgG anti-echinococcal antibody titres of 14.27 U/mL. Based on that and the imaging findings of abdominal ultrasound (US), Computed Tomography (CT) and Magnetic Resonance (MR) the diagnosis of a recurrent retrorectal pelvic hydatid cyst was made. Three courses of oral albendazole treatment were administered and sixteen weeks later, the patient was admitted for a planned elective operation. At that time, a new CT scan revealed disappearance of the cyst, while the serological tests showed a decrease in the IgG anti-echinococcal antibody titres to 0. 71 U/mL. Four different species of the Echinococcus tapeworm can produce infection in humans. E granulosus and E multilocularis are the most common, causing cystic and alveolar echinococcosis respectively, while E vogeli and E oligarthrus, have only rarely been associated with human infection. Although surgical resection remains the treatment of choice for hydatid disease, the present case could suggest that especially in cases of recurrent intraabdominal extrahepatic hydatid cyst, treatment with albendazole may lead to disappearance of the recurrent cyst therefore, should constitute a first line therapeutic option prior to any planned reoperation.
Καμπερίδου, Ειρήνη (2007). Απόψεις Ξένων Περιηγητριών για την Περίοδο της Τουρκοκρατίας: «Δυστυχώς οι πόλεις είναι γεμάτες Έλληνες (1853). ΦΙΛΟΣΟΦΙΑ & ΠΑΙΔΕΙΑ, Περιοδική Επιστημονική Έκδοση της Ένωσης Καθηγητών για την Προαγωγή της Φιλοσοφίας στην Εκπαίδευση (ΕΚΔΕΦ), ‘Έτος 13ο , Τεύχος 41 (Ιανουάριος-Απρίλιος 2007): 34-37. J.5 in APELLA
BACKGROUND: Disruptive behavior is common in Alzheimer disease (AD). There are conflicting reports regarding its ability to predict cognitive decline, functional decline, institutionalization, and mortality.
OBJECTIVE: To examine whether the presence of disruptive behavior has predictive value for important outcomes in AD.
DESIGN: Using the Columbia University Scale for Psychopathology in Alzheimer Disease (administered every 6 months, for a total of 3438 visit-assessments and an average of 6.9 per patient), the presence of disruptive behavior (wandering, verbal outbursts, physical threats/violence, agitation/restlessness, and sundowning) was extracted and examined as a time-dependent predictor in Cox models. The models controlled for the recruitment cohort, recruitment center, informant status, sex, age, education, a comorbidity index, baseline cognitive and functional performance, and neuroleptic use.
SETTING: Five university-based AD centers in the United States and Europe (Predictors Study).
PARTICIPANTS: Four hundred ninety-seven patients with early-stage AD (mean Folstein Mini-Mental State Examination score, 20 of 30 at entry) who were recruited and who underwent semiannual follow-up for as long as 14 (mean, 4.4) years.
MAIN OUTCOME MEASURES: Cognitive (Columbia Mini-Mental State Examination score, < or = 20 of 57 [approximate Folstein Mini-Mental State Examination score, < or = 10 of 30]) and functional (Blessed Dementia Rating Scale score, parts I and II, > or = 10) ratings, institutionalization equivalent index, and death.
RESULTS: At least 1 disruptive behavioral symptom was noted in 48% of patients at baseline and in 83% at any evaluation. Their presence was associated with increased risks of cognitive decline (hazard ratio 1.45 [95% confidence interval (CI), 1.03-2.03]), functional decline (1.66 [95% CI, 1.17-2.36]), and institutionalization (1.47 [95% CI, 1.10-1.97]). Sundowning was associated with faster cognitive decline, wandering with faster functional decline and institutionalization, and agitation/restlessness with faster cognitive and functional decline. There was no association between disruptive behavior and mortality (hazard ratio, 0.94 [95% CI, 0.71-1.25]).
CONCLUSION: Disruptive behavior is very common in AD and predicts cognitive decline, functional decline, and institutionalization but not mortality.
c-Jun is a transcription factor activated by phosphorylation by the stress-activated protein kinase/c-Jun N-terminal kinase pathway in response to extracellular signals and cytokines. We show that adenovirus-mediated gene transfer of the dominant negative form of c-Jun (dn-c-Jun) in C57BL/6 mice increased greatly apoE hepatic mRNA and plasma levels, increased plasma cholesterol, triglyceride, and very low density lipoprotein levels, and resulted in the accumulation of discoidal high density lipoprotein particles. A similar but more severe phenotype was generated by overexpression of the mouse apoE in C57BL/6 mice, suggesting that dyslipidemia induced by dn-c-Jun was the result of apoE overexpression. Unexpectedly, infection of apoE(-/-) mice with adenovirus expressing dn-c-Jun reduced plasma cholesterol by 70%, suggesting that dn-c-Jun affected other genes that control plasma cholesterol levels. To identify these genes, we performed whole genome expression analysis (34,000 genes) of isolated livers from two groups of five apoE(-/-) mice, infected with adenoviruses expressing either the dn-c-Jun or the green fluorescence protein. Bioinformatic analysis and Northern blotting validation revealed that dn-c-Jun increased 40-fold the apoE mRNA and reduced by 70% the Scd-1 (stearoyl-CoA-desaturase 1) mRNA. The involvement of Scd-1 in lowering plasma cholesterol was confirmed by restoration of high cholesterol levels of apoE(-/-) mice following coinfection with adenoviruses expressing dn-c-Jun and Scd-1. In conclusion, dn-c-Jun appears to trigger two opposing events in mice that affect plasma cholesterol and triglyceride levels as follows: one results in apoE overexpression and triggers dyslipidemia and the other results in inhibition of Scd-1 and offsets dyslipidemia.
OBJECTIVES: To report on recent efforts in the field of consumer health informatics (CHI) and education.
METHODS: A review of the literature we selected on using search engines and Medline with terms from consumer health informatics and education. Twenty two articles match these criteria.
RESULTS: A great diversity of work spans the field of CHI. This relatively new field now faces challenges due to rapidly advancing technologies and the increasing empowerment of citizens connected over the worldwide web.
CONCLUSION: The benefits of enhancing CIH components within existing medical curricula are already being noted. Additionally, updated recommendations on health and medical informatics should incorporate CHI.
The rationale of this magnetoencephalographic (MEG) study was the quest for temporal aspects of the fMRI-characterized hemispheric asymmetries of auditory cortex functions during the processing of simple linearly frequency-modulated (FM) tones. We searched for parameters which distinguish a stimulus-related task condition—the categorical discrimination of direction (upward versus downward) of frequency modulation—from mere exposure to the same FM tones. We found that the M100-peak latency after FM tones was significantly shorter in the task condition than in the exposure condition, in the left but not in the right hemisphere.
OBJECTIVES: Aim of this study is the evaluation of the impact of a multimedia CD (MCD) on preoperative anxiety and postoperative recovery of patients undergoing elective laparoscopic cholecystectomy (LC).
METHODS: Sixty consecutive candidates for elective LC were randomly assigned to four groups. Group A included 15 patients preoperatively informed regarding LC through the MCD presented by Registered Nurse (RN). Patients in group B (n = 15) were informed through a leaflet. Patients in group C (n = 15) were informed verbally from a RN. Finally, the control Group D included 15 patients informed conventionally by the attending surgeon and anesthesiologist, as every other patient included in groups A, B, and C. Preoperative assessment of knowledge about LC was performed after each informative session through a questionnaire. Evaluation of preoperative anxiety was conducted using APAIS scale. Postoperative pain and nausea scores were measured using an NRS scale, 16 hours after the patient had returned to the ward.
RESULTS: Statistical processing of the results (single linear regression) showed that patients in groups A, B, and C achieved a higher knowledge score, less preoperative anxiety score and less postoperative pain and nausea, compared to Group D. In multiple regression analysis, group A had a higher knowledge score compared to the four groups (p < 0.001 r(2) = 0.41).
CONCLUSION: Informative sessions using MCD is an effective means of improving patient's preoperative knowledge, especially in day-surgery cases, like LC.
Immunomodulatory drugs (IMiDs) and bortezomib have been recently used in the management of patients with both newly diagnosed and relapsed/ refractory multiple myeloma. Except of their direct anti-myeloma effect, these agents also alter the interactions between myeloma cells and marrow microenvironment. Several recent studies have investigated their potential effect on myeloma bone disease. Preclinical studies have demonstrated that IMiDs reduce osteoclast formation and function in vitro. Clinical studies have confirmed that thalidomide reduces markers of bone resorption, while lenalidomide induces osteoclast arrest in myeloma patients. However, IMiDs seem to have no effect on osteoblast exhaustion present in myeloma. The proteasome inhibitor bortezomib restores abnormal bone remodeling through the inhibition of osteoclast function and the increase in osteoblast differentiation and activity in vitro. In myeloma patients, bortezomib reduces biochemical markers of bone resorption and normalizes the RANKL/osteoprotegerin ratio, while at the same time increases bone formation markers reducing levels of dickkopf-1 protein. Whether these effects are direct and not only a consequence of the agents' antimyeloma activity is not totally clear. This review summarizes all available data for these attractive agents that combine potent anti-myeloma activity with beneficial effects on bone and may alter the way of management of myeloma-related bone disease.
BACKGROUND: A 9-month course of isoniazid monotherapy is currently recommended for the treatment of latent tuberculosis infection (LTBI) and has been shown to be effective in both children and adults. Reduced compliance with this regimen has forced physicians to explore shorter regimens. The aim of this study was to compare 3- and 4-month combination regimens of isoniazid plus rifampin with a 9-month regimen of isoniazid monotherapy for the treatment of LTBI in children. METHODS: This prospective, randomized, controlled study was conducted over an 11-year period (1995-2005). In period 1 (1995-1998), 232 patients received isoniazid therapy for 9 months (group A), and 238 patients received isoniazid and rifampin for 4 months (group B). In period 2 (1999-2002), 236 patients were treated with isoniazid and rifampin for 4 months (group C), and 220 patients received the same regimen for 3 months (group D). All patients were observed for > or = 3 years. RESULTS: Overall compliance with treatment was good, but patients who received isoniazid monotherapy were less compliant than were those who received short-course combination therapy (P=.011, for group A vs. group B; P=.510, for group C vs. group D). No patient in any group developed clinical disease during the follow-up period. New radiographic findings suggestive of possible active disease were more common in patients who received isoniazid monotherapy (24%) than in those treated with shorter regimens (11.8%, 13.6%, and 11% for groups B, C, and D, respectively; P=.001 for group A vs. group B; P=.418 for group C vs. group D). Serious drug-related adverse effects were not detected. CONCLUSIONS: Short-course treatment with isoniazid and rifampin for 3-4 months is safe and seems to be superior to a 9-month course of isoniazid monotherapy.
BACKGROUND: Skeletal muscle wasting commonly occurs in patients with chronic obstructive pulmonary disease (COPD) and has been associated with the presence of systemic inflammation. This study investigated whether rehabilitative exercise training decreases the levels of systemic or local muscle inflammation or reverses the abnormalities associated with muscle deconditioning.
METHODS: Fifteen patients with COPD (mean (SE) forced expiratory volume in 1 s 36 (4)% predicted) undertook high-intensity exercise training 3 days/week for 10 weeks. Before and after the training programme the concentration of tumour necrosis factor alpha (TNFalpha), interleukin-6 (IL-6) and C-reactive protein (CRP) in plasma was determined by ELISA, and vastus lateralis mRNA expression of TNFalpha, IL-6, total insulin-like growth factor-I (IGF-I) and its isoform mechanogrowth factor (MGF) and myogenic differentiation factor D (MyoD) were assessed by real-time PCR. Protein levels of TNFalpha, IGF-I and MyoD were measured by Western blotting.
RESULTS: Rehabilitation improved peak exercise work rate by 10 (2%) (p = 0.004) and mean fibre cross-sectional area from 4061 (254) microm(2) to 4581 (241) microm(2) (p = 0.001). Plasma inflammatory mediators and vastus lateralis expression of TNFalpha and IL-6 were not significantly modified by training. In contrast, there was a significant increase in mRNA expression of IGF-I (by 67 (22)%; p = 0.044), MGF (by 67 (15)%; p = 0.002) and MyoD (by 116 (30)%; p = 0.001). The increase observed at the mRNA level was also seen at the protein level for IGF-I (by 72 (36)%; p = 0.046) and MyoD (by 67 (21)%; p = 0.012).
CONCLUSIONS: Pulmonary rehabilitation can induce peripheral muscle adaptations and modifications in factors regulating skeletal muscle hypertrophy and regeneration without decreasing the levels of systemic or local muscle inflammation.
{This study evaluated and compared the effectiveness of two different off-season, short-term basketball training programs on physical and technical abilities of young basketball players. Twenty-seven adolescent basketball players (14.7 ± 0.5 years; Tanner stage: 3.5 ± 0.5) were randomly divided into a specialized basketball training group (SP
{This study evaluated and compared the effectiveness of two different off-season, short-term basketball training programs on physical and technical abilities of young basketball players. Twenty-seven adolescent basketball players (14.7 ± 0.5 years; Tanner stage: 3.5 ± 0.5) were randomly divided into a specialized basketball training group (SP
The Leonardo project under the name European Interprofessional Education Network (EIPEN) in health and social care, has been dealing with the challenges of Interprofessional Education (IPE). The EIPEN project tries to develop a transnational network of universities and employers in the six participating countries and at the same time to promote good practices in Interprofessional LearningTeaching in healthsocial care. IPE provides opportunities for students and practitioners to learn with, from and about each other during qualifying and post-qualifying training and in their practice. IPE in health and social care includes the education and training of practitioners in human and animal medicine, dentistry, nursing, physiotherapy, occupational therapy, pharmacy and all other health professions including public and environmental health and health promotion, and social work. The outcomes of the EIPEN Project will provide means, material and guidelines for the enhancement of professional education in the multidisciplinary field of Health Informatics.
The present work demonstrates the first application of Brillouin light scattering (BLS) to probe film-guided elastic waves in transparent-substrate supported polymer thin films. In comparison with earlier BLS studies that were restricted to films either free-standing or supported on opaque substrates, the progress made in this work substantially extends the applicability of BLS and permits direct access to the elastic properties of thin films lying on transparent substrates, which is of important practical relevance. A series of thin supported polystyrene and poly(methyl methacrylate) films with thickness in the range of 40−500 nm were explored, and no noticeable trend in elastic properties with thickness has been found, in conformity with earlier BLS results. The first measurement of glass transition temperature, Tg, of supported polymer thin films by BLS is also reported. We observed that the ultrathin (40 nm) films for both polymers exhibit a clear reduction in Tg.
Hydatid disease, although endemic mostly in sheep-farming countries, remains a public health issue worldwide, involving mainly the liver. Intrabiliary rupture is the most frequent complication of the hepatic hydatid cyst. Endoscopy is advocated, preoperatively, to alleviate obstructive jaundice caused by intracystic materials after a frank rupture and is also a useful and well-established adjunct in locating postoperative biliary fistulas. Endoscopic retrograde cholangiography with sphincterotomy has been successful as the sole and definitive means of treatment of intrabiliary ruptured hydatid cysts. A case of an elderly woman with frank rupture is presented, where the rupture was definitively managed endoscopically in conjunction with sphincterotomy to remove the intrabiliary obstructive daughter cysts and to achieve decontamination of the biliary tree. Endoscopic retrograde cholangiography provided an excellent diagnostic and therapeutic modality in the present case and, thus, it should be considered as definitive treatment in similar cases especially if surgical risk is anticipated to be high.
In this work we study the transport properties of hybrids that consist of exchange biased ferromagnets (FMs) combined with a low-T-c superconductor (SC). Not only different FMs but also various structural topologies have been investigated: results for multilayers of La1-xCaxMnO3 combined with Nb in the form of [La0.33Ca0.67MnO3/La0.60Ca0.40MnO3](15)/Nb, and for more simple Ni80Fe20/Nb/Ni80Fe20 trilayers and Ni80Fe20/Nb bilayers are presented. The results obtained in all hybrid structures studied in this work clearly uncover that the exchange bias mechanism promotes superconductivity. Our findings assist the understanding of the contradictory results that have been reported in the recent literature regarding the transport properties of relative FM/SC/FM spin valves.
We have studied the spatial and temporal variation of the surface longwave radiation (downwelling and net) over a 21-year period in the tropical and subtropical Pacific Ocean (40 S-40 N, 90 E-75 W). The fluxes were computed using a deterministic model for atmospheric radiation transfer, along with satellite data from the ISCCP-D2 database and reanalysis data from NCEP/NCAR (acronyms explained in main text), for the key atmospheric and surface input parameters. An excellent correlation was found between the downwelling longwave radiation (DLR) anomaly and the Niño-3.4 index time-series, over the Niño-3.4 region located in the central Pacific. A high anti-correlation was also found over the western Pacific (15-0 S, 105-130 E). There is convincing evidence that the time series of the mean downwelling longwave radiation anomaly in the western Pacific precedes that in the Niño-3.4 region by 3-4 months. Thus, the downwelling longwave radiation anomaly is a complementary index to the SST anomaly for the study of ENSO events and can be used to asses whether or not El Niño or La Niña conditions prevail. Over the Niño-3.4 region, the mean DLR anomaly values range from +20 Wm-2 during El Niño episodes to -20 Wm-2 during La Niña events, while over the western Pacific (15-0 S, 105-130 E) these values range from -15 Wm-2 to +10 Wm-2, respectively. The long- term average (1984-2004) distribution of the net downwelling longwave radiation at the surface over the tropical and subtropical Pacific for the three month period November-December-January shows a net thermal cooling of the ocean surface. When El Niño conditions prevail, the thermal radiative cooling in the central and south-eastern tropical Pacific becomes weaker by 10 Wm-2 south of the equator in the central Pacific (7-0 S, 160-120 W) for the three-month period of NDJ, because the DLR increase is larger than the increase in surface thermal emission. In contrast, the thermal radiative cooling over Indonesia is enhanced by 10 Wm-2 during the early (August-September-October) El Niño phase.
INTRODUCTION: Taking into consideration the need for an updated survey on acute myocardial infarction (AMI) in Greece, we conducted the HELIOS study (HELlenic Infarction Observation Study), aiming to recruit a cohort of AMI patients that would be representative of the total AMI population.
METHODS: The HELIOS study is a countrywide registry of AMI, conducted during 2005-2006 by the Prevention Working Group of the Hellenic Cardiological Society. We enrolled 1840 AMI pts from 31 hospitals (mean age 68 +/- 13 years, 75% men, 1096 ST-elevation myocardial infarction [STEMI] patients), with a proportional representation of all types of hospitals and of all geographical areas. The study recruited 10% of the total number of AMI cases that occur per year on a countrywide basis, taking into consideration the seasonal variations of the population in each geographical area.
RESULTS: Despite demographic changes, there is still a male predominance among AMI patients and an increasing prevalence of cardiometabolic risk factors, (obesity, diabetes, hypertension) compared to previous AMI studies in the Greek population. Almost 60% of STEMI patients received reperfusion therapy, but the median value of the pain-to-door time was 180 minutes. The rates of administration of evidence-based medications during hospitalisation or upon discharge and the short-term mortality rates were in accordance with those observed in other international AMI registries.
CONCLUSIONS: The HELIOS study provided valuable insights into the epidemiology, clinical characteristics, management and outcome of patients with AMI in the Greek population. Although there are notable advances compared to previous reports, there is still considerable room for improvement and we should particularly focus on minimising the time delay between arrival at the emergency department and performance of reperfusion, by either pharmacological or catheter-based approaches.
BACKGROUND: Inhibition of lung cell apoptosis in the bronchoalveolar lavage (BAL) of septic patients may have a prognostic value for the severity of sepsis. The present study evaluated apoptosis in the nasal and buccal mucosa of septic patients as an alternative and less invasive approach for studying the cells involved in bronchial inflammation.
PATIENTS AND METHODS: A prospective study was designed. Nasal and buccal mucosa brushings were obtained from 20 consecutive septic patients who were admitted to two intensive care units. Twenty-four patients scheduled to undergo surgery for colorectal cancer or laparascopic cholocystectomy were the control group. Apoptosis was evaluated using a TUNEL assay, while BCL-2 and BAX expression were evaluated by immunohistochemistry.
RESULTS: Significantly reduced apoptosis in the nasal mucosa of septic patients compared to the control group (p=0.043) was detected only by the TUNEL assay.
CONCLUSION: Reduced apoptosis was found during sepsis in the nasal mucosa in accordance with the reduced apoptosis in the lungs of septic patients. In contrast to septic lungs the underlying mechanism leading to apoptosis in the nasal mucosa was unrelated to the expression of two apoptosis-related genes BCL-2 and BAX.
Saddam Hussein’s execution on Saturday December 31, 2006 and its broadcast over the internet in the form of video footage “leaked” by one of the bystanders constitutes a milestone of important geostrategic developments in the Middle East, mainly as a multiplier of the Shia-Sunni tension, between the followers of Moktanta al Sadr and the Sunnis, between the Shiites of Tehran and the Lebanese Muslims (Shiites and Sunnis). The execution also triggered a chain reaction of the Kurdish ethnic pockets in the area, starting with Iraqi Kurdistan. This reaction engages Turkey in the issue of geostrategic reshuffling in the area and provides its military regime with the opportunity to use this threat to achieve EU tolerance as regards the country’s accession process without having to implement the necessary adjustments stipulated by the “acquis communautaire” and without trying to clear the “Cyprus hurdle” in the course of the entry talks. Greece and Cyprus must adopt a coordinated approach at all levels to deal with this situation, in which even “hot conflict provocations” by Turkey against Greece, but also an increase of pressure from across the Atlantic directed against Levkosia and Athens, cannot be ruled out.
The paper studies changes in daily precipitation records at the National Observatory, Athens, during the period 1891-2004. This is the longest available time series of precipitation for Greece. The results show that both the shape and scale parameter of a fitted two parameter gamma distribution for the last two decades do show a significant difference of these parameters, when compared to any previous period from the 1890s through the 1970s. Also important changes are observed in daily precipitation totals exceeding various thresholds such as 10, 20, 30 and 50 mm. More specifically, a negative trend in the number of wet days (remarkable after 1968) and a positive trend in extreme daily precipitation are evident. The changes of heavy and extreme precipitation events in this part of SE Europe have significant environmental consequences which cause considerable damage and loss of life.
{The authors determine from first principles the Curie temperature T-C for bulk Co in the hcp, fcc, bcc, and body-centered-tetragonal (bct) phases, for FeCo alloys, and for bcc and bct Fe. For bcc Co
FR258900 has been discovered as a novel inhibitor of human liver glycogen phosphorylase a and proved to suppress hepatic glycogen breakdown and reduce plasma glucose concentrations in diabetic mice models. To elucidate the mechanism of inhibition, we have determined the crystal structure of the cocrystallized rabbit muscle glycogen phosphorylase b-FR258900 complex and refined it to 2.2 angstrom resolution. The structure demonstrates that the inhibitor binds at the allosteric activator site, where the physiological activator AMP binds. The contacts from FR258900 to glycogen phosphorylase are dominated by nonpolar van der Waals interactions with Gln71, Gln72, Phe196, and Val45' (from the symmetry-related subunit), and also by ionic interactions from the carboxylate groups to the three arginine residues (Arg242, Arg309, and Arg310) that form the allosteric phosphate-recognition subsite. The binding of FR258900 to the protein promotes conformational changes that stabilize an inactive T-state quaternary conformation of the enzyme. The ligand-binding mode is different from those of the potent phenoxy- phthalate and acyl urea inhibitors, previously described, illustrating the broad specificity of the allosteric site.
Early genetic and physiological work in bacteria and fungi has suggested the presence of highly specific nucleobase transport systems. Similar transport systems are now known to exist in algae, plants, protozoa and metazoa. Within the last 15 years, a small number of microbial genes encoding nucleobase transporters have been cloned and studied in great detail. The sequences of several other putative proteins submitted to databases are homologous to the microbial nucleobase transporters but their physiological functions remain largely undetermined. In this review, genetic, biochemical and molecular data are described concerning mostly the nucleobase transporters of Aspergillus nidulans and Saccharomyces cerevisiae, the two model ascomycetes from which the great majority of data come from. It is also discussed as to what is known on the nucleobase transporters of the two most significant pathogenic fungi: Candida albicans and Aspergillus fumigatus. Apart from highlighting how a basic process such as nucleobase recognition and transport operates, this review intends to highlight features that might be applicable to antifungal pharmacology.
BACKGROUND: Although General Practice (GP) was recognized as a medical specialty in Greece in 1986, the number of GPs is insufficient to cover needs and only few medical graduates choose GP as a career option. In the present study we investigated the profile of medical students in terms of their decisions regarding specialization and the possible association of career choices different from GP with the status of undergraduate training regarding GP.
METHODS: The sample consisted of final year students in the Medical School of the University of Athens, Greece. Students filled in a self-reported questionnaire focusing on medical specialization, and GP in particular.
RESULTS: Response rate was 82.5% with 1021 questionnaires collected, out of 1237 eligible medical students. Only 44 out of the 1021 (4.3%) respondents stated that GP is -or could be- among their choices for specialty. The most popular medical specialty was General Surgery (10.9%), followed by Cardiology (9.6%), Endocrinology (8.7%) and Obstetrics-Gynaecology (8.3%). The most common criterion for choosing GP was the guaranteed employment on completion of the residency (54.6%) while a 56.6% of total respondents were positive to the introduction of GP/FM as a curriculum course during University studies.
CONCLUSION: Despite the great needs, GP specialty is currently not a career option among undergraduate students of the greater Medical University in Greece and is still held in low esteem. A university department responsible for undergraduate teaching, promotion and research in GP (where not available) is essential; the status of undergraduate training in general practice/family medicine seems to be one of the most important factors that influence physician career choices regarding primary care specialties.
The Lebanon II war required the utmost attention, in foreign policy terms, from both Greece and Cyprus. This is because the conflict between Israel and Lebanon resulted in obvious dangers for the flaring up of all the national-state and ethnic actors in the region.
This paper is a geopolitical and geostrategic analysis of the Israel-Hezbollah asymmetric war. It also unveils how Iran and Syria influence the Middle East geostrategic subsystem and the Lebanon case.
This paper examines the lessons learned from the IsraelHezbollah war at a political and military level. It demonstrates the political benefits for Israel in security terms, and its military weak points. It also unveils how Iran and Syria influence the Middle East geostrategic subsystem and the Lebanon case, and suggests that a US attack against Iran is not realistic. It draws on valid evidence and statements by political figures from all involved parties.
Despite the long lasting research the ideal method of reconstructing the ACL has not been found so far. The last year's attention has shifted to the use of the multistrand hamstring tendon grafts. High ultimate tensile load, multiple-bundle replacement that better approximates the anatomy of the normal ACL and low donor site morbidity are the main advantages of this ACL replacement graft. These theoretical advantages have been multiplied when surprisingly studies have shown that semitendinosus and gracilis tendons actually regenerate after harvesting for use as ACL autografts. In this review article we summarize the current knowledge concerning the hamstring regeneration and we focus on issues that have clinical relevance or issues that have not been answered so far.
Depressed cardiac Ca cycling by the sarcoplasmic reticulum (SR) has been associated with attenuated contractility, which can progress to heart failure. The histidine-rich Ca-binding protein (HRC) is an SR component that binds to triadin and may affect Ca release through the ryanodine receptor. HRC overexpression in transgenic mouse hearts was associated with decreased rates of SR Ca uptake and delayed relaxation, which progressed to hypertrophy with aging. The present study shows that HRC may mediate part of its regulatory effects by binding directly to sarco(endo)plasmic reticulum Ca-ATPase type 2 (SERCA2) in cardiac muscle, which is confirmed by coimmunostaining observed under confocal microscopy. This interaction involves the histidine- and glutamic acid-rich domain of HRC (320-460 aa) and the part of the NH(2)-terminal cation transporter domain of SERCA2 (74-90 aa) that projects into the SR lumen. The SERCA2-binding domain is upstream from the triadin-binding region in human HRC (609-699 aa). Specific binding between HRC and SERCA was verified by coimmunoprecipitation and pull-down assays using human and mouse cardiac homogenates and by blot overlays using glutathione S-transferase and maltose-binding protein recombinant proteins. Importantly, increases in Ca concentration were associated with a significant reduction of HRC binding to SERCA2, whereas they had opposite effects on the HRC-triadin interaction in cardiac homogenates. Collectively, our data suggest that HRC may play a key role in the regulation of SR Ca cycling through its direct interactions with SERCA2 and triadin, mediating a fine cross talk between SR Ca uptake and release in the heart.
We give an overview of [1], in collaboration with G. Skandalis, where we construct the holonomy groupoid and the C*-algebras associated with any singular foliation (in the sense of Stefan and Sussmann).
A cross-sectional study was carried out in healthy company employees from Greece with the aim of assessing the prevalence of human herpesvirus 8 (HHV-8) and identifying risk factors for this herpesviral infection. Serum samples obtained from 955 subjects were tested for antibodies to HHV-8 by the K8.1 enzyme-linked immunosorbent assay (ELISA). Associations between HHV-8 serostatus and potential risk factors were examined using t-test, chi square test, and multivariate logistic regression analysis. HHV-8 prevalence was 7.6% (95% confidence interval (CI): 6.0%, 9.5%) and it increased with age from 6.5% among <30 years old to 13.8% among > or =50 years old subjects (P = 0.006). HHV-8 seropositivity was independently associated with endoscopic examination (odds ratio (OR): 2.01; 95% CI: 1.09, 3.70; P = 0.026), HBsAg positivity (OR: 5.16; 95% CI: 2.02, 13.20; P = 0.001) and age (OR > or =50 years old vs. <50 years old: 2.09; 95% CI: 1.23, 3.52; P = 0.006). No statistically significant associations between HHV-8 positive status and gender, occupational status, surgery, transfusion, tattoos/body piercing, multiple sex partners, weakness/fatigue, HCV status were observed. HHV-8 is prevalent in Greece. The strong association between HBV infection and HHV-8 positive status supports the hypothesis of an association between these two viral infections. The association between HHV-8 seropositivity and endoscopic examination requires further investigation.
The phononic band structure of two binary colloidal crystals, at hypersonic frequencies, is studied by means of Brillouin light scattering and analyzed in conjunction with corresponding dispersion diagrams of the single colloidal crystals of the constituent particles. Besides the acoustic band of the average medium, the authors’ results show the existence of narrow bands originating from resonant multipole modes of the individual particles as well as Bragg-type modes due to the (short-range) periodicity. Strong interaction, leading to the occurrence of hybridization gaps, is observed between the acoustic band and the band of quadrupole modes of the particles that occupy the largest fractional volume of the mixed crystal; the effective radius is either that of the large (in the symmetric NaCl-type crystalline phase) or the small (in the asymmetric NaZn13 -type crystalline phase) particles. The possibility to reveal a universal behavior of the phononic band structure for different single and binary colloidal crystalline suspensions, by representing in the dispersion diagrams reduced quantities using an appropriate length scale, is discussed.
In June 2005, the work of the EU Integrated Project EuroPrevall was started. EuroPrevall is the largest research project on food allergy ever performed in Europe. Major aims of the project are to generate for the first time reliable data on the prevalence of food allergies across Europe and on the natural course of food allergy development in infants. Improvement of in vitro diagnosis of food allergies is another important aim of the project. The present review summarizes current knowledge about the clinical presentation of food allergy and critically reviews available diagnostic tools at the beginning of the project period. A major problem in diagnosis is a relatively poor 'clinical specificity', i. e. both positive skin tests and in vitro tests for specific IgE are frequent in sensitized subjects without food allergy symptoms. So far, no in vitro test reliably predicts clinical food allergy. EuroPrevall aims at improving the predictive value of such tests by proceeding from diagnosis based on allergen extracts to purified allergen molecules, taking into account the affinity of the IgE-allergen interaction, and evaluating the potential of biological in vitro tests such as histamine release tests or basophil activation tests including assays performed with permanently growing cell lines.
OBJECTIVE: To characterize deficits in nonverbal recognition memory and functional brain changes associated with these deficits in Alzheimer disease (AD).
METHODS: Using O-15 PET, we studied 11 patients with AD and 17 cognitively intact elders during the combined encoding and retrieval periods of a nonverbal recognition task. Both task conditions involved recognition of line drawings of abstract shapes. In both conditions, subjects were first presented a list of shapes as study items, and then a list as test items, containing items from the study list and foils. In the titrated demand condition, the shape study list size (SLS) was adjusted prior to imaging so that each subject performed at approximately 75% recognition accuracy; difficulty during PET scanning in this condition was approximately matched across subjects. A control task was used in which SLS = 1 shape.
RESULTS: During performance of the titrated demand condition, SLS averaged 4.55 (+/-1.86) shapes for patients with AD and 7.53 (+/-4.81) for healthy elderly subjects (p = 0.031). However, both groups of subjects were closely matched on performance in the titrated demand condition during PET scanning with 72.17% (+/-7.98%) correct for patients with AD and 72.25% (+/-7.03%) for elders (p = 0.979). PET results demonstrated that patients with AD showed greater mean differences between the titrated demand condition and control in areas including the left fusiform and inferior frontal regions (Brodmann areas 19 and 45).
CONCLUSIONS: Relative fusiform and inferior frontal differences may reflect the Alzheimer disease (AD) patients' compensatory engagement of alternate brain regions. The strategy used by patients with AD is likely to be a general mechanism of compensation, rather than task-specific.
OBJECTIVES: Health informatics is a well established and important multi-disciplinary and inter-disciplinary field that not only involves informatics but also medicine, nursing, engineering, biology and other-related subjects. The program has been organized on the basis of an inter-university approach with the participation of five Greek universities. The paper aims at providing a current description of the academic program and a preliminary evaluation of the implementation phase.
METHODS: The paper presents a case study of a curriculum implementation from the phase of curriculum development to the phase of implementation and evaluation. Due to the interdisciplinary character of the course appropriate procedures were undertaken to ensure that mixed backgrounds can assimilate the broad spectrum of the teaching material taught. In the first stages of the implementation international students mainly from Europe attended the course. In addition, local graduates provided an extra dimension to the multi-layered difficulties and challenges of such a course implementation.
RESULTS: The students registered in the course were from different backgrounds and disciplines. They were mainly from health sciences and engineering schools. The interdisciplinary arrangement of the course facilitated the proper exchange of thoughts, skills, and knowledge among and between students and teachers.
CONCLUSIONS: The postgraduate course in health informatics at the University of Athens has now been running for more than fifteen consecutive years and is one of the first and longest standing courses in Europe. Continuous evaluation and adaptation is required to fit within the changing and evolving amazing field of biomedical and health informatics.
The in vitro utilization of biocompatible ferromagnetic nanoparticles (BFNs) in hemodialysis (HD), routinely used today for the treatment of end stage renal disease (ESRD), is introduced in this work. The proposed strategy is termed magnetically assisted hemodialysis (MAHD) and it aims to become a more efficient development of conventional HD. The method is based on the production of biocompatible ferromagnetic nanoparticles-targeted binding substances conjugates (BFNs-TBSs Cs) constructed of BFNs and specifically designed TBSs that should have high affinity and binding capacity for target toxic substances (TTSs) which must be removed from the ESRD patient subjected to HD. Antibodies or even specific proteins could serve as the TBS of the desired BFNs-TBSs Cs. The BFNs-TBSs Cs should be administered to the patient timely prior to the MAHD session so as to bind with the desired TTSs during their free circulation in the vascular network. Eventually, the complete BFNs-TBSs-TTSs structure can be selectively removed during the MAHD session by means of an external inhomogeneous magnetic field that is applied either at the dialyzer or at other collection point(s) along the blood circulation line of the dialysis machine. The advantages of MAHD over conventional HD regarding the patient's comfort and overall health status are discussed in detail among practical issues. To examine this proposition we employed Fe3O4 and bovine serum albumin (BSA) as the BFN and the TBS constituents respectively, since they are both highly biocompatible. By means of x-ray diffraction, atomic force microscopy, circular dichroism spectropolarimetry, UV-vis spectrophotometry, SQUID magnetometry, and nuclear magnetic resonance we evaluated (i) the structural/morphological characteristics, (ii) the magnetic retraction efficiency, and most importantly (iii) the toxin binding affinity and capacity of both bare Fe3O4 BFNs and Fe3O4-BSA Cs by performing in vitro experiments on specific TTSs. Homocysteine and p-cresol were chosen as representative TTSs and were investigated in great detail. The results obtained prove the in vitro applicability of the proposed MAHD method.
BACKGROUND: In North America and Europe, human immunodeficiency virus (HIV)-1 infection has typically been dominated by subtype B transmission. More recently, however, non-B subtypes have been increasingly reported in Europe. METHODS: We analyzed 1158 HIV-1-infected individuals in Greece by DNA sequencing and phylogenetic analyses of protease and partial reverse-transcriptase regions. RESULTS: We found that the prevalence of non-B subtypes has increased over time and that this significant trend can be mainly attributed to subtype A, which eventually surpassed subtype B in prevalence in 2004 (42% and 33%, respectively). Multivariate analysis revealed that the year of HIV diagnosis was independently associated with subtype A infection (odds ratio for being infected with subtype A for a 10-year increase in the time period of diagnosis, 2.09 [95% confidence interval, 1.36-3.24]; P<.001). Phylogenetic analysis revealed that the subtype A epidemic in Greece is the result of a single founder event. The date of the most recent common ancestor of the subtype A in Greece was estimated to be 1977.9 (95% highest posterior density interval, 1973.7-1981.9). CONCLUSIONS: Subtype A circulates among the long-term residents of Greece. This is in contrast to the situation in most European countries, in which infection with non-B genetic forms is associated either with being an immigrant or heterosexual or with intravenous drug use.
The synthesis of the C5' tert-butyl ketone of thymidine 1a and 2'-deoxyguanosine 2 is achieved by reaction of 5'-C-cyano derivatives with tert-butyl lithium followed by acid hydrolysis. The 5'R configuration is assigned by X-ray crystal structure determination of an opportunely protected derivative of 1a. The (5'S)-isomers of both nucleosides are not stable, and a complete decomposition occurs in the reaction medium. The photochemistry of 1a and 2 effectively produced the thymidin-5'-yl radical and the 2'-deoxyguanosin-5'-yl radical, respectively. In the thymidine system, the C5' radical is fully quenched in the presence of a physiological concentration of thiols. In the 2'-deoxyguanosine system, the C5' radical undergoes intramolecular attack onto the C8-N7 double bond of guanine leading ultimately to the 5',8-cyclo-2'-deoxyguanosine derivative. The cyclization of the 2'-deoxyguanosin-5'-yl radical occurs with a rate constant of ca. 1 x 10(6) s(-1) and is highly stereoselective affording only the (5'S)-diastereomer.
Helmis CG a, Tzoutzas J b, Flocas HA a, Halios CH a, Stathopoulou OI a, Assimakopoulos VD c, Panis V b, Apostolatou M a, Sgouros G a, Adam E b. Indoor air quality in a dentistry clinic. Science of the Total Environment [Internet]. 2007;377:349-365. WebsiteAbstract
Helmis CG, Tzoutzas J, Flocas HA, Halios CH, Stathopoulou OI, Assimakopoulos VD, Panis V, Apostolatou M, Sgouros G, Adam E. Indoor air quality in a dentistry clinic. Science of the Total Environment [Internet]. 2007;377:349-365. Website
Santamouris M, Argiroudis K, Georgiou M, Livada I, Doukas P, Assimakopoulos MN, Sfakianaki A, Pavlou K, Geros V, Papaglastra M. Indoor air quality in fifty residences in Athens. International Journal of Ventilation [Internet]. 2007;5:367-380. Website
The vortex matter phase diagrams of aluminum doped Mg1-xAlxB2 crystals, deduced from local Hall ac-susceptibility (for H parallel to c axis) and bulk dc-magnetization measurements (for H parallel to c axis and ab plane) are reported. As in pristine and carbon doped MgB2, aluminum substituted crystals display the peak effect in the critical current. The peak effect is located very close to the H-c2(c)(T) line, while it disappears below a characteristic magnetic field H-* that depends on Al content. The absence of significant bulk pinning below the onset of the peak effect implies that the Bragg glass phase is present there. In some of the crystals the peak effect is not present as a sharp negative peak of the real part of the local ac susceptibility, but it appears as a negative double-peak feature. This observation may be related with the miscibility gap that occurs for 0.05 <= x <= 0.5. For low aluminum content the H-c2(c)(T) line lies slightly above the corresponding one of the pristine MgB2, but for higher aluminum content, T-c, H-c2(ab,c)(0), and anisotropy parameter gamma=H-c2(ab)(0)/H-c2(c)(0) take lower values when compared to pristine MgB2. Similarly with the pristine MgB2 crystals for the superconducting aluminum substituted crystals, the anisotropy parameter decreases monotonously as temperature increases as well. All the experimental observations could be qualitatively explained within the clean two-band approximation.
We report a randomised prospective study comparing two implants, the Gamma trochanteric nail and the ACE trochanteric nail, in the treatment of intertrochanteric femoral fractures in the elderly. One hundred and twelve patients were randomised on admission into two treatment groups. Fifty-six patients were treated with Gamma nail implants, and 56 were treated with ACE trochanteric nail. The average age of these patients was 78 years. Twenty fractures were stable and 92 unstable. The mean follow-up time was 8 months (6 -12). Regular clinical and radiological review was done 1, 3 and 6 months postoperatively. Operation time, fluoroscopy time, blood transfusion and complications were recorded. The mobility score was used to assess the pre-injury and postoperative mobility status. All the patients were treated within 36 h of their accident. There were no complications during surgery. All the patients were mobilised in the first 24 h postoperatively, regardless of the fracture type, and weight bearing was permitted as tolerated. Union of the fracture was achieved in all patients. There was no statistically significant difference between the two groups with regard to the studied parameters. There was no mechanical failure of the implants despite the early patient mobilisation. Early operation and early mobilisation resulted in a good functional outcome in all patients. Both the trochanteric gamma nail and ACE trochanteric nail provide effective methods of treatment for intertrochanteric fractures in elderly patients.
Because of the aging of the population, dementia has become a major public health problem. There has been growing evidence for a possible association between lipids and dementia. A large body of literature has demonstrated multiple hypothesized biologic links between lipids and neurodegenerative or other biologic pathways connected to dementing processes. However, the epidemiologic associations have been conflicting: dyslipidemia at middle age, but not in later life, seems to be associated with higher dementia risk in some but not all studies. Results from the Honolulu-Asia Aging Study reported by Saczynski et al. (Am J Epidemiol 2007;165:985-92) suggest that lipoprotein constituents, such as apolipoprotein A-I, a major component of the high density lipoprotein, may be more informative in enlightening the association between lipids and dementia. In this commentary, the epidemiology and biology of apolipoprotein A-I in relation to dementia is reviewed.
BACKGROUND: High rates of leisure activity have been associated with reduced risk of Alzheimer disease (AD).
OBJECTIVE: To determine whether prediagnosis leisure activity modifies the rate of cognitive decline in patients with AD.
DESIGN: Inception cohort followed up longitudinally for a mean of 5.3 years (up to 13.9 years).
SETTING: Urban community.
PARTICIPANTS: A total of 283 patients with incident AD (mean age, 79 years; 56.2% Hispanic and 31.1% African American).
MAIN OUTCOME MEASURES: Change in a composite cognitive score from diagnosis on and during the entire study follow-up.
RESULTS: In multivariate-adjusted generalized estimating equation models of postdiagnosis change (n = 133), each leisure activity was associated with an additional yearly decline of 0.005 of a z-score unit in cognitive score (P = .17). In models expanded to include cognitive change during study follow-up, including evaluations before and after diagnosis (n = 283), each activity was associated with an additional yearly decline of 0.005 of a z-score unit in cognitive score (P = .03). The association was strongest for intellectual activities.
CONCLUSIONS: Greater participation in prediagnosis leisure activities, especially intellectual activities, was associated with faster cognitive decline, supporting the hypothesis that the disease course in AD may vary as a function of cognitive reserve.
Context: Classical novae are quite frequent in M 31. However, very few spectra of M 31 novae have been studied to date, especially during the early decline phase. Aims: Our aim is to study the photometric and spectral evolution of a M 31 nova event close to outburst. Methods: Here, we present photometric and spectroscopic observations of M31N 2005-09c, a classical nova in the disk of M 31, using the 1.3 m telescope of the Skinakas Observatory in Crete (Greece), starting on the 28th September, i.e. about 5 days after outburst, and ending on the 5th October 2005, i.e. about 12 days after outburst. We also have supplementary photometric observations from the La Sagra Observatory in Northern Andalucía, Spain, on September 29 and 30, October 3, 6 and 9 and November 1, 2005. The wavelength range covered by the spectra is from 3565 Å to 8365 Å. The spectra are of high S/N allowing the study of the evolution of the equivalent widths of the Balmer lines, as well as the identification of non-Balmer lines. Results: The nova displays a typical early decline spectrum that is characterized by many weak Fe II multiplet emissions. It is classified as a Pfe nova. From the nova light curve, we have also derived its speed class, t_2=14±2.5 days. As the nova evolved the Balmer lines became stronger and narrower. The early decline of the expansion velocity of the nova follows a power law in time with an exponent of ≃-0.2.
We present numerical simulations of axisymmetric, magnetically driven relativistic jets. Our special-relativistic, ideal-magnetohydrodynamics numerical scheme is specifically designed to optimize accuracy and resolution and to minimize numerical dissipation. In addition, we implement a grid-extension method that reduces the computation time by up to three orders of magnitude and makes it possible to follow the flow up to six decades in spatial scale. To eliminate the dissipative effects induced by a free boundary with an ambient medium we assume that the flow is confined by a rigid wall of a prescribed shape, which we take to be z ~ ra (in cylindrical coordinates, with a ranging from 1 to 3). We also prescribe, through the rotation profile at the inlet boundary, the injected poloidal current distribution: we explore cases where the return current flows either within the volume of the jet or on the outer boundary. The outflows are initially cold, sub-Alfvénic and Poynting flux-dominated, with a total-to-rest-mass energy flux ratio μ ~ 15. We find that in all cases they converge to a steady state characterized by a spatially extended acceleration region. The acceleration process is very efficient: on the outermost scale of the simulation as much as ~ 77 per cent of the Poynting flux has been converted into kinetic energy flux, and the terminal Lorentz factor approaches its maximum possible value (Γ∞ ~= μ). We also find a high collimation efficiency: all our simulated jets (including the limiting case of an unconfined flow) develop a cylindrical core. We argue that this could be the rule for current-carrying outflows that start with a low initial Lorentz factor (Γ0 ~ 1). Our conclusions on the high acceleration and collimation efficiencies are not sensitive to the particular shape of the confining boundary or to the details of the injected current distribution, and they are qualitatively consistent with the semi-analytic self-similar solutions derived by Vlahakis and Königl. We apply our results to the interpretation of relativistic jets in active galactic nuclei: we argue that they naturally account for the spatially extended accelerations inferred in these sources (Γ∞ >~ 10 attained on radial scales R >~ 1017cm) and are consistent with the transition to the matter-dominated regime occurring already at R >~ 1016cm.
We present numerical simulations of axisymmetric, magnetically driven relativistic jets. Our special-relativistic, ideal-magnetohydrodynamics numerical scheme is specifically designed to optimize accuracy and resolution and to minimize numerical dissipation. In addition, we implement a grid-extension method that reduces the computation time by up to three orders of magnitude and makes it possible to follow the flow up to six decades in spatial scale. To eliminate the dissipative effects induced by a free boundary with an ambient medium we assume that the flow is confined by a rigid wall of a prescribed shape, which we take to be z ~ ra (in cylindrical coordinates, with a ranging from 1 to 3). We also prescribe, through the rotation profile at the inlet boundary, the injected poloidal current distribution: we explore cases where the return current flows either within the volume of the jet or on the outer boundary. The outflows are initially cold, sub-Alfvénic and Poynting flux-dominated, with a total-to-rest-mass energy flux ratio μ ~ 15. We find that in all cases they converge to a steady state characterized by a spatially extended acceleration region. The acceleration process is very efficient: on the outermost scale of the simulation as much as ~ 77 per cent of the Poynting flux has been converted into kinetic energy flux, and the terminal Lorentz factor approaches its maximum possible value (Γ∞ ~= μ). We also find a high collimation efficiency: all our simulated jets (including the limiting case of an unconfined flow) develop a cylindrical core. We argue that this could be the rule for current-carrying outflows that start with a low initial Lorentz factor (Γ0 ~ 1). Our conclusions on the high acceleration and collimation efficiencies are not sensitive to the particular shape of the confining boundary or to the details of the injected current distribution, and they are qualitatively consistent with the semi-analytic self-similar solutions derived by Vlahakis and Königl. We apply our results to the interpretation of relativistic jets in active galactic nuclei: we argue that they naturally account for the spatially extended accelerations inferred in these sources (Γ∞ >~ 10 attained on radial scales R >~ 1017cm) and are consistent with the transition to the matter-dominated regime occurring already at R >~ 1016cm.
We examine a quantum dot (QD) illuminated in the near field with subwavelength spatial resolution, while simultaneously it is subjected to a magnetic field of variable orientation and magnitude. The magnetic field orientation can conserve or destroy the zero-magnetic-field ("structural") symmetry. The asymmetry induced by the magnetic field -except for specific orientations along symmetry axes- can be uncovered in the near-field (NF) but not in the far-field (FF) spectra. We predict that NF magnetoabsorption experiments of realistic spatial resolution could reveal the QD symmetry. This exceptional symmetry-resolving power of the near-field optics, is lost in the far field.
Viral infections of the respiratory tract are the most common precipitants of acute asthma exacerbations. Exacerbations are only poorly responsive to current asthma therapies and new approaches to therapy are needed. Viruses, most frequently human rhinoviruses (RV), infect the airway epithelium, generate local and systemic immune responses, as well as neural responses, inducing inflammation and airway hyperresponsiveness. Using in vitro and in vivo experimental models the role of various proinflammatory or anti-inflammatory mediators, antiviral responses and molecular pathways that lead from infection to symptoms has been partly unravelled. In particular, mechanisms of susceptibility to viral infection have been identified and the bronchial epithelium appeared to be a key player. Nevertheless, additional understanding of the integration between the diverse elements of the antiviral response, especially in the context of allergic airway inflammation, as well as the interactions between viral infections and other stimuli that affect airway inflammation and responsiveness may lead to novel strategies in treating and/or preventing asthma exacerbations. This review presents the current knowledge and highlights areas in need of further research.
BACKGROUND: We previously reported that the Mediterranean diet (MeDi) is related to lower risk for Alzheimer disease (AD). Whether MeDi is associated with subsequent AD course and outcomes has not been investigated.
OBJECTIVES: To examine the association between MeDi and mortality in patients with AD.
METHODS: A total of 192 community-based individuals in New York who were diagnosed with AD were prospectively followed every 1.5 years. Adherence to the MeDi (0- to 9-point scale with higher scores indicating higher adherence) was the main predictor of mortality in Cox models that were adjusted for period of recruitment, age, gender, ethnicity, education, APOE genotype, caloric intake, smoking, and body mass index.
RESULTS: Eighty-five patients with AD (44%) died during the course of 4.4 (+/-3.6, 0.2 to 13.6) years of follow-up. In unadjusted models, higher adherence to MeDi was associated with lower mortality risk (for each additional MeDi point hazard ratio 0.79; 95% CI 0.69 to 0.91; p = 0.001). This result remained significant after controlling for all covariates (0.76; 0.65 to 0.89; p = 0.001). In adjusted models, as compared with AD patients at the lowest MeDi adherence tertile, those at the middle tertile had lower mortality risk (0.65; 0.38 to 1.09; 1.33 years' longer survival), whereas subjects at the highest tertile had an even lower risk (0.27; 0.10 to 0.69; 3.91 years' longer survival; p for trend = 0.003).
CONCLUSION: Adherence to the Mediterranean diet (MeDi) may affect not only risk for Alzheimer disease (AD) but also subsequent disease course: Higher adherence to the MeDi is associated with lower mortality in AD. The gradual reduction in mortality risk for higher MeDi adherence tertiles suggests a possible dose-response effect.
BACKGROUND: Higher adherence to the Mediterranean diet (MeDi) has been related to lower Alzheimer's disease risk. Some dietary factors have been studied in patients with essential tremor (ET), but the MeDi's effect has not been investigated.
METHODS: Adherence to the MeDi was calculated from a food frequency questionnaire administered in a case-control study of environmental epidemiology of ET in the New York Tri-State area. Logistic regression models were used to examine whether adherence to the MeDi predicted ET (vs. control) outcome. The models adjusted for age, gender, ethnicity, education, caloric intake, body mass index, smoking, ethanol consumption, coffee intake and blood harmane concentrations.
RESULTS: 148 ET cases adhered less to MeDi (0-9 scale with higher scores indicating higher adherence) than 250 controls (mean 4.3 +/- 1.7 vs. 4.7 +/- 1.7; p = 0.03). Higher adherence to MeDi was associated with lower odds for ET [0.78 (0.61-0.99); p = 0.042]. As compared to subjects at the lowest MeDi adherence tertile, those at the middle tertile had lower ET odds [0.41 (0.16-1.05)], while subjects at the highest tertile had an even lower ET odds [0.29 (0.10-0.82); p for trend 0.021].
CONCLUSIONS: Compared to controls, ET cases adhered less to MeDi. The gradual reduction in ET odds with higher MeDi adherence tertiles suggests a possible dose-response effect. The mechanisms that underlie this association merit further study.
Drug absorption is a complex process dependent upon drug properties such as solubility and permeability, formulation factors, and physiological variables including regional permeability differences, pH, luminal and mucosal enzymes, and intestinal motility, among others. Despite this complexity, various qualitative and quantitative approaches have been proposed for the estimation of oral drug absorption. These approaches are reviewed in this article with particular emphasis on drug dissolution modelling, dynamic systems for oral absorption and absorption models based on structure. The regulatory aspects of oral drug absorption and in particular the biopharmaceutic classification of drugs are also discussed. Models for drug dissolution and release describe adequately the in vitro data, and models for oral drug absorption provide reasonable results. The development of in vitro-in vivo correlations based on the official compendia specifications are facilitated using commercial computer packages.
We use Monte Carlo simulations in order to study diffusion controlled drug release from matrices consisting of random mixtures of high and low diffusivity areas (random mixing), and from matrices covered by a thin film of low diffusivity (ordered mixing). We compared our results with the Weibull model for drug release and found that it provides an adequate description of the release process in all cases of random mixing and most cases of ordered mixing. We have studied the dependence of the Weibull parameters on the diffusion coefficient and, in most cases, found a rather simple linear dependence. Moreover, our results indicate that a device covered by a thin film with diffusion coefficient three orders of magnitude lower that the coefficient of the rest of the device, will release drug at constant rate for most of the release process. This last result may have considerable practical applications. (C) 2007 Elsevier B.V. All rights reserved.
INTRODUCTION: Prediction of soft-tissue outline shape from skeletal remains is useful in forensics and archaeology. The inverse problem, the assessment of underlying skeletal relationships from the external appearance, is pertinent in orthodontics. The purposes of this study were to assess the correlation between craniofacial shape and shape of the soft-tissue profile outline and to determine the extent to which it might be possible to predict the latter from the former.
METHODS: Lateral cephalograms from 170 consecutive orthodontic patients were used, and 17 skeletal, 2 dental, and 22 soft-tissue landmarks were digitized and processed by using Procrustes superimposition and principal component analysis. The principal components of the skeletal and soft-tissue shapes were entered into the correlation analysis.
RESULTS: Significant correlations were found between the skeletal and the soft-tissue components. The use of 7 anterior skeletal landmarks (not including the nasal bone) resulted in a predictive power (coefficient of determination) of 38% of the variability of soft-tissue shape. This increased to almost 50% by adding nasal and incisor points but showed only a slight further improvement by incorporating posterior skeletal landmarks.
CONCLUSIONS: Anterior skeletal and dental landmarks can be used to predict soft-tissue profile shape with a 50% power in children and adolescents.
INTRODUCTION: Soft-tissue facial outline has been studied by conventional cephalometric methods, and differences between the 2 sexes have been identified, mainly related to size and timing of growth. However, shape per se was not sufficiently evaluated, especially regarding variability, age-related changes, and sexual dimorphism. The purpose of this study was to evaluate shape variability and sexual dimorphism of the soft-tissue outline by using morphometric methods.
METHODS: Pretreatment lateral cephalograms from 170 consecutive patients (82 male, 88 female) aged 7 to 17 years were used. Fifteen skeletal and 22 soft-tissue landmarks were digitized and processed with Procrustes superimposition and principal component analysis. The principal components (PCs) of the soft-tissue shape were analyzed in relation to age and sex.
RESULTS: The first 8 PCs explained approximately 90% of the total shape variability. The first coefficient (PC1) related to lip, nose, and chin prominence and included 36% of total shape variability. It was significantly correlated to age, but with a low coefficient of determination (r2 = 13%). The second coefficient (PC2) related to facial convexity and explained 18% of shape variability. The next 2 coefficients were mainly related to lower lip shape. Statistically significant sexual dimorphism was detected, but the overall shape differences between the average profiles of boys and girls were minor and barely detectable visually. Shape dimorphism was present both before and after the age of 12 years.
CONCLUSIONS: Shape variability related mainly to relative lip protrusion, convexity of the face, and lower lip shape. Shape differences between the sexes seemed to exist even before the pubertal growth spurt, but they were small. Age changes in shape appeared more significant.
BACKGROUND: Numerous studies have implicated neurogenesis in the hippocampus in animal models of depression, especially those related to controllability and learned helplessness. Here, we tested the hypothesis that uncontrollable but not controllable stress would reduce cell proliferation in the hippocampus of male and female rats and would relate to the expression of helplessness behavior.
METHODS: To manipulate controllability, groups of male and female rats were trained in one session (acute stress) or over seven sessions (repeated stress) to escape a footshock, whereas yoked control subjects could not escape but were exposed to the same amount of stress. Cell proliferation was assessed with immunohistochemistry of bromodeoxyuridine (BrdU) and immunofluorescence of BrdU and neuronal nuclei (NeuN). Separate groups were exposed to either controllable or uncontrollable stress, and their ability to learn to escape during training on a more difficult task was used as a behavioral measure of helplessness.
RESULTS: Acute stress reduced cell proliferation in males but did not affect proliferation in the female hippocampus. When animals were given the opportunity to learn to control the stress over seven days, males produced more cells than the yoked males without control. Repeated training with controllable stress did not influence proliferation in females. Under all conditions, males were more likely than females to express helplessness behavior, even males that were not previously stressed.
CONCLUSIONS: The modulation of neurogenesis by controllability was evident in males but not in females, as was the expression of helplessness behavior, despite the fact that men are less likely than women to experience depression.
Previous research has shown that some associative learning tasks prevent the death of new neurons in the adult hippocampus. However, it is unclear whether it is mere exposure to the training stimuli that rescues neurons or whether successful learning of the task is required for enhanced neuronal survival. If learning is the important variable, then animals that learn better given the same amount of training should retain more of the new cells after learning than animals that do not learn as well. Here, we examined the effects of training versus learning on cell survival in the adult hippocampus. Animals were injected with BrdU to label a population of cells and trained one week later on one of two trace conditioning tasks, one of which depends on the hippocampus and one that does not. Increases in cell number occurred only in animals that acquired the learned response, irrespective of the task. There were significant correlations between acquisition and cell number, as well as between asymptotic performance and cell number. These data support the idea that learning and not simply training increases the survival of the new cells in the hippocampus.
AIM: The aim of this study was to investigate the relationship between the activation level of certain protagonist muscles of the upper and lower body during the shot-put with the shot-put performance in skilled athletes.
METHODS: Eight experienced right-handed shot-putters, performed the shot-put with the linear technique. They also performed a maximum (1RM) squat and a 1RM incline bench-press strength test. Electromyographic (EMG) signals were recorded from the m. quadriceps vastus lateralis (VL), m. gastrocnemius internus, m. pectoralis major (PEC) and the m. triceps brachii (TRI) of the right side during all efforts. The level of EMG during the shot-put was normalized relatively to that measured during the respective maximum strength test.
RESULTS: Shot-put performance was significantly correlated with 1RM squat (r=0.76, P<0.05) and 1RM bench-press (r=0.75, P<0.05) as well as with the average EMG from VL and PEC after taking the power position (r=0.91, P<0.01 and r=0.75, P<0.05, respectively). A close negative relationship was also found between shot-put performance and the time to reach peak activation of right TRI during the explosive strike of the throwing arm (r=-0.70, P<0.05).
CONCLUSION: These results suggest that, besides the importance of absolute muscle strength, an important parameter for shot-put performance is the level of activation of the VL and the PEC during the delivery phase. Furthermore, these data suggest that the TRI should be activated fast in order to be an effective contributor to the shot-put performance.
Social capital is a key component in understanding the relationship between European sport governing bodies and civil society. A core concept in sociology, political science, organizational behaviour and business, social capital is relatively new in the context of European sport governance. In exploring the boundaries of both sport and social capital in theory and practice, one can see sport as a form of positive social capital that promotes social cohesion, trust, social ties, etc. However, it could also be perceived as ・・dark・・ social capital since the politics of sport do not always deliver the social benefits they proclaim due to the ・・exclusionary・・ vs. inclusive factors: commercialization, doping, institutionalized gender personification, the leaky pipeline and the glass ceiling in SGBs and in competitive sports. Sport has not yet evolved into a form of social capital which can be nurtured and reproduced to raise social cohesion and eliminate social exclusions.
Social capital is a key component in understanding the relationship between European sport governing bodies and civil society. A core concept in sociology, political science, organizational behaviour and business, social capital is relatively new in the context of European sport governance. In exploring the boundaries of both sport and social capital in theory and practice, one can see sport as a form of positive social capital that promotes social cohesion, trust, social ties, etc. However, it could also be perceived as «dark» socialcapital since the politics of sport do not always deliver the social benefits they proclaim due to the «exclusionary» vs. inclusive factors: commercialization, doping, institutionalized gender personification, the leaky pipeline and the glassceiling in SGBs and in competitive sports. Sport has not yet evolved into a form of social capital which can be nurtured and reproduced to raise social cohesion and eliminate social exclusions.KEY WORDS: sport as social capital, «dark» social capital insports, social capital production/reproduction, gender personificationin sports, leaky pipeline and glass ceiling.
We report the discovery of an optical nova in M31 on four consecutive dithered R filter CCD images (each with 100 sec exposure) obtained on 2007 July 25.92564, 25.92714, 25.92865, 25.93015 with corresponding R magnitudes of 18.1, 18.2, 18.1, 18.1 obtained at the 1.3m f/7.5 telescope at Skinakas Observatory, Crete, Greece, using an Andor DZ436-BV CCD Camera. The position obtained for the nova candidate is RA(2000) = 00 42 43.29 , Dec(2000) = +41 17 44.10 with an accuracy of 0.2".
We report the discovery of an optical nova candidate in M 31 on ten stacked R filter CCD images (each with 60 sec exposure) obtained on 2007 Aug 30.018 with an R magnitude of 17.8 obtained at the 60cm f/8 Ganymed telescope located at Skinakas Observatory, Crete, Greece, using a ST10XME CCD Camera. The object is confirmed on CCD images with the same telescope using a broad H-alpha filter (4*120 s stacked, 17.7 mag) obtained on 2007 Aug 30.029.
We report the discovery of an optical nova candidate in the outer disk of M 31 on nine stacked R filter images (each with 60 sec exposure) and four stacked 12nm H-alpha filter images (each with 120 sec exposure) on 2007 Aug 24.081 and 24.093 with a magnitude of 18.7 in R and 18.1 in H-alpha, respectively. The images were obtained at the 60cm f/3 Ganymed telescope located at Skinakas Observatory, Crete, Greece, using a STL11000M CCD Camera.
