Publications

In Press
Poutzalis S, Anastasiadou A, Nasopoulou C, Megalemou K, Sioriki E, Zabetakis I. Evaluation of the in vitro anti-atherogenic activities
of goat milk and goat dairy products
. Dairy Science and Technology [Internet]. In Press. Publisher's VersionAbstract
Given that goat milk and dairy products should be consumed daily according to suggestions based on Mediterranean diet, the current study evaluates the anti-atherogenic properties of goat milk and goat dairy products (yogurt and white cheese). Total lipids (TLs) of all three samples were extracted by the method of Bligh and Dyer and further separated into total polar lipids (TPLs) and total neutral lipids (TNLs) by counter current distribution. The fatty acid profiles of TPL and TNL of all three samples were determined by gas chromatography analysis. TL and TPL were tested to determine whether they induce platelet aggregation or inhibit platelet aggregation induced by the platelet-activating factor (PAF). The most active lipids were found in goat white cheese (i.e., since they showed lower IC50 values in both TL and TPL samples than corresponding fractions of goat milk and goat yogurt), so the TPL of goat white cheese were further separated by preparative thin-layer chromatography (TLC). The obtained polar lipid fractions after TLC separation were also tested for their biological activity. All the samples’ lipids, and especially the polar ones, were found to exhibit strong anti-atherogenic activities. This fact highlights the nutritional value of goat dairy products in terms of cardioprotection, as PAF is a crucial inflammatory mediator that is implicated in the mechanism of atherogenesis.
Chatoupis C, Vagenas G. Physical education teachers' use of Moston's teaching styles: a literature review. The Physical Educator. In Press.
Παπαρρηγοπούλου-Πεχλιβανίδη Πατρίνα. Οι επιπτώσεις των “μνημονειακών παρεμβάσεων” στην κοινωνική ασφάλιση. ΕΔΚΑ. In Press. oi_epiptoseis_ton_mnimoneiakon_paremvaseon_stin_koinoniki_asfalisi.pdf
Forthcoming
Archaeological Research in the Kurdistan Region of Iraq and the adjacent areas. Conference Proceedings, Athens, November 1st-3rd 2013. (Kopanias K, MacGinnis J). Oxford: Archaeopress; Forthcoming. Website
Kopanias K. Das Straßennetz der Ostphokis und die Frage nach der Lokalisierung von Abai. In: Niemeier W-D Kalapodi Vorberichte. Berlin: DAI; Forthcoming. Website
Kamberidou I, Pascall N. The Digital Skills Crisis: Engendering Technology – Empowering Women in Cyberspace. Journal of Innovation and Entrepreneurship, A Springer Open Journal . Forthcoming;(Special Issue).Abstract
This article examines current research on the digital skills crisis, focusing on the factors that contribute to digital exclusion.  Through an analysis of current literature on the digital divide, the authors discuss the digital skills gaps, namely the exclusion of a sizeable part of the workforce from the digital market economy—women in particular. The gender imbalance in ICT and related sectors persists today, despite decades of equal opportunity policies, legislation and government initiatives. Women are still underrepresented and digitally excluded and efforts to attract, recruit and retain girls and women in ICT and STEM seem to be failing, reinforcing the gender participation gap, pay gap, and leadership gap. Inspiring girls and women into technology requires innovative approaches and raising the profile of our role models and female leaders. Engendering ICTs entails women’s agency.  Accordingly, the authors conclude with advice–recommendations from three inspirational and successful women entrepreneurs who have made a difference.Keywords:  Digital Divide, Digital Exclusion, Gender Gaps, Skills Gap, Women Entrepreneurs, Leadership Gap, Digitalization, Digital Inequality, Digital Literacy, Gender Devaluation, Technology and Social Inclusion
Karavanta M. William V. Spanos’s Onto-Political Criticism: Risky A-filiations and the Call of the Korē’s Meidiama.”. boundary 2. Forthcoming.Abstract
This essay discusses William V. Spanos’s work as the legacy of what can be called “onto-political criticism.” Spanos’s affiliation between texts and the world discloses the overlapping of the history of imperialistic and colonial violence with the politics of ontology, what constitutes the discourses, ideologies and institutions that produce and consolidate the metaphysics of imperialism. Drawing on Martin Heidegger and the poststructuralists, Spanos’s work demonstrates how metaphysics is not inconsequential; it is the discursive and political reproduction of a certain concept of being as a measure for other humans and as a philosophical and political justification for their dispossession, enslavement and extermination that is the very fist act of colonization. His insistence on the poststructuralists’ legacy of an antihumanist practice that desires to articulate the poetics and politics of the ontologies of alterity is not indifferent to politics. Spanos thus unearths the “overlapping territories and intertwined histories” (Said) constitutive of the polis within the histories of colonialism, imperialism and neo-imperialism, the latter being his key focus in his analyses of American exceptionalism in the age of globalization. His onto-political a-filiation establishes the possibility of articulating a kind of criticism that, while recognizing the history of this axiomatics of ontopology, also imagines and articulates the potentiality that is ex-centric (the derivative and negative prefix “a-” signifies this) to its narratives, discourses and politics. Spanos’s legacy opens the possibility for a community of method driven by “the thought of a differential polity,” a constitutive element of a truly democratic politeia.  
Vassiloyannis P. Person's Dominion: Inviolability, Method, and Value.; Forthcoming.
Kopanias K. From the Mythical Atreus to the Ruler Attarissiya. Aegean Kingship in the Late Bronze Age through the Prism of Near Eastern Texts. In: Kaiser I, Kouka O, Panagiotopoulos D Ein Minoer im Exil. Festschrift zum 65. Geburtstag von Wolf-Dietrich Niemeier. Bonn: Habelt; Forthcoming. Website
Kopanias K, Fox S. Headshaping at Tell Nader. In: Mina M, Papadatos Y, Triantaphyllou S Embodied Identities In The Prehistoric Eastern Mediterranean: Convergence Of Theory And Practices. Conference hosted by the University of Cyprus, 10-12 April 2012, Nicosia, Cyprus. Oxford: Oxbow Books; Forthcoming. Website
Coakley J, Dotsis G, Liu H, Zhai J. Investor Sentiment and Value and Growth Stock Index Options. European Journal of Finance. Forthcoming.
Kopanias K. Mycenaean Mercenaries in the Service of Suppiluliuma II?. In: Polychronakou-Sgouritsa P, Palaggia O Proceedings of a Symposion in Memory of Professor Spyridon Iakovides. Athens; Forthcoming.
Καμπερίδου Ειρήνη.

ΨΗΦΙΑΚΕΣ ΔΕΞΙΟΤΗΤΕΣ ΚΑΙ ΤΟ ΕΜΦΥΛΟ ΨΗΦΙΑΚΟ ΧΑΣΜΑ

. Πρακτικά του 6ου ΣΥΝΕΔΡΙΟ ΤΗΣ ΕΛΛΗΝΙΚΗΣ ΚΟΙΝΩΝΙΟΛΟΓΙΚΗΣ ΕΤΑΙΡΕΙΑΣ «Η κοινωνιολογία και ο δημόσιος ρόλος της στην εποχή της μεταμόρφωσης του κόσμου». Forthcoming.Abstract
Ο ψηφιακός εγγραμματισμός λειτουργεί ως εξαιρετικό μέσον για την ισόνομη μεταχείριση και πλήρη ενσωμάτωση κοινωνικά αποκλεισμένων ομάδων στην κοινωνία της πληροφορίας. Προβαίνοντας σε μια ανάλυση των πρόσφατων ερευνών και συζητήσεων για το ψηφιακό χάσμα, τις απαιτούμενες σήμερα ψηφιακές δεξιότητες και τη μελλοντική ζήτηση, αυτή η μελέτη επικεντρώνεται στην έμφυλη διάσταση. Ερευνητικά δεδομένα επιβεβαιώνουν ότι δεκαετίες προτάσεων και παρεμβάσεων—ερευνητικών, πολιτικών, κοινωνικών, νομοθετικών—δεν αύξησαν τη γυναικεία συμμετοχή στους κλάδους των STEM (επιστήμη, τεχνολογία,  μηχανική, μαθηματικά) και τις Τεχνολογίες της Πληροφορίας και Επικοινωνίας (ΤΠΕ). Οι γυναίκες αποτελούν αόρατη μειονότητα σε αυτούς τους τομείς, παρά τις ενέργειες του κινήματος για την κοινωνική ενσωμάτωση/ένταξη των γυναικών και κοριτσιών στις ΤΠΕ και την ευρεία αναγνώριση της σημαντικότητας των ψηφιακών δεξιοτήτων που απαιτούνται σήμερα στους χώρους εργασίας της Ευρωπαϊκής Ένωσης. Τα αποτελέσματα εμπειρικών ερευνών αναδεικνύουν τη ζωτική σημασία αναμόρφωσης της εκπαίδευσης STEM ώστε να συμπεριλάβει την έμφυλη διάσταση, δεδομένου ότι οι κοινωνικές προκαταλήψεις ξεκινούν από μικρή ηλικία. Επισημαίνεται, επίσης και η  αναγκαιότητα να καθορισθούν και να καταγραφούν από τους βιομηχανικούς θεσμούς οι πραγματικές ανάγκες, οι συγκεκριμένες απαιτήσεις και οι ψηφιακές δεξιότητες που απαιτούνται σήμερα. Η μελέτη αυτή ολοκληρώνεται με μια συνοπτική αναφορά στις  πολύτιμες συμβουλές διακεκριμένων γυναικών στην κοινωνία της πληροφορίας και των ΤΠΕ: Nancy Pascall, Όλγα Σταυροπούλου, Rosalie Zobel, και Elizabeth Pollitzer.   Λέξεις κλειδιά: ψηφιακό χάσμα, φύλο, έμφυλη υποτίμηση (gender devaluation), ψηφιακές δεξιότητες, ψηφιακός εγγραμματισμός μαθητών/τριών, πληροφορικός γραμματισμός (information literacy)
sociology_in_times_of_crisis_certificate.pdf
Karavanta M.

"The Illegal Human: Democracy In-Surgent"

. Journal of Contemporary Thought. Special Issue Speaking Truth to Power, Ed. R.Radhakrishnan. Forthcoming.Abstract
The history of the human as excess that cannot be eliminated and is the body of exappropriation, the body of a différance is repeated in the present. It is the history of the illegal human being written by the multiple crossings of borders by a growing number of peoples who are refugees, exiles, and economic immigrants without documents. This is an old history--as Achille Mbembe reminds us in his analysis of le nègre in Critique de la Raison Négre--but also a new one. The substantive of the nègre is now being replaced by the substantive of the illegal as the people without documents or the boat people are often called. The illegal is a substantive whose repetition registers the stark denotations of danger and threat and is used by the state authorities and the media to vindicate the European policies and practices that separate the immigrant from the human, once again repeating the fate of the stateless human without rights. By drawing on Mbembe’s analysis of   le nègre and the promise of a humanity in-surgent and Jacques Derrida’s “strange syntagma” of a democracy-to-come, this essay demonstrates how this particular story of the illegal human is another twist in the long history of the human as a subject of exappropriation who speaks truth to power while bearing the promise of a humanity that is in-surgent, which is the promise for a democracy radically different from the neoliberal model available in the present. The essay discusses how this “to come” of democracy invokes the discomfort zone of becoming human in the company of those humans whose lives are precarious and are exempted from the present democratic imaginaries as examples of bare life or, even more poignantly called, beastly life.  
Apostolou I. Photographier l'Autre (1839-1914) : le regard orientaliste des voyageurs français.; Forthcoming.Abstract
Du voyageur-photographe, qui sélectionne ses sujets parmi les gens du pays, au voyageur-collectionneur, qui visite les ateliers commerciaux pour acheter des épreuves, le voyage fut à l’origine d’une production photographique orientaliste diversifiée qui ne fut pas constituée comme un genre autonome, mais se situa à la frontière de plusieurs catégories. Inspirés d’une iconographie stéréotypée déjà en vogue, les photographes commerciaux photographièrent les types ethniques et religieux orientaux et en racontèrent, de manière discontinue, la vie quotidienne, les mœurs et les coutumes ainsi que les activités professionnelles. Dans des conditions souvent difficiles, les voyageurs représentèrent aussi l’Autre oriental. Plusieurs voyageurs gardèrent son image comme souvenir, tandis que d’autres exécutèrent des photographies à caractère anthropologique ou ethnographique. Nombreuses sont aussi les photographies qui rappellent le caractère religieux de l’Orient et montrent l’activité missionnaire. Conçues dans un autre esprit, les photographies des touristes reproduisent une image vivante bien que parfois stéréotypée des Orientaux. Quoique morcelée, l’image des Orientaux formée par les photographies des voyageurs, contribua à la formation de l’identité de l’Oriental. Révélatrice de leur idéologie, leur production, qui s’inscrit dans le contexte de l’orientalisme dénoncé par Edward Saïd, transmet des informations sur la manière dont ils l’avaient perçu. Médiateurs culturels, les photographes français, voyageurs ou résidents, familiarisèrent la population orientale avec l’art de la photographie.  
Popular religion and ritual in the east Mediterranean from the 3rd millennium BC to the 5th century AD. Proceedings of the International Conference by the Department of History and Archaeology of the University of Athens, December 2013. (Vavouranakis G, Papadatos Y, Kopanias K, Kanellopoulos C). Oxford: Oxbow Books; Forthcoming. Website
Kamberidou I. Revealing experiences hidden from history: Through the eyes of women travelers in the Eastern Mediterranean and Black Sea regions in the 17th to early 20th centuries. International Conference: "Port cities and maritime routes in Eastern Mediterranean and Black Sea (18th – 21st century)”. Forthcoming.
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Blondel J, Aronson J, Bodiou J-Y, Boeuf G. Η Μεσογειακή περιοχή: Βιοποικιλότητα στο χώρο και το χρόνο
. Αθήνα: Παρισιάνου; Forthcoming.
Despotopoulou A. "'Monuments of an artless age': Hotels and women’s mobility in the work of Henry James". Studies in the Novel. Forthcoming.
Kopanias K, Beuger C, MacGinnis J, Ur J. The Tell Baqrta Project in the Kurdistan Region of Iraq. In: MacGinnis J Proceedings of the Conference Provincial Archaeology of the Assyrian Empire, December 13-Saturday December 15 2012, organized by the MacDonald Institute for Archaeological Research of the University of Cambridge. Cambridge: McDonald Institute Monographs Series; Forthcoming. Publisher's Version
Kopanias K, MacGinnis J. The Tell Nader Project in the Erbil Province: the Stratigraphy. In: Kopanias K Archaeological Research in the Kurdistan Region of Iraq and the adjacent areas. Conference Proceedings, Athens, November 1st-3rd 2013. Oxford: Archaeopress; Forthcoming.
Kopanias K. Ubaid ‘islands’ in a non-Ubaid ‘sea’: An Attempt to Define the Ubaid and its Cultural Boundaries in Northeastern Mesopotamia. In: Baysal E, Karakatsanis L Bordered Places. Bounded Times. Cross-disciplinary perspectives on Turkey. London: The British Institute at Ankara; Forthcoming. Publisher's Version kopanias_ubaid.pdf
Kopanias K. An Ubaid Kiln at Tell Nader (Kurdistan Region in Iraq). In: Masetti-Rouault MG, Rouault O Proceedings of the International Congress “Archaeology and History of the Empires: Models, projects and work in progress in Northern Mesopotamia. New programs in Iraqi Kurdistan”, Paris, Ecole Pratique des Hautes Etudes, Sorbonne, 14-15 juin 2013. EMMS I. Paris; Forthcoming.
Triantafyllou A, Dotsis G, Sarris AH. Volatility Forecasting and Time-Varying Variance Risk Premiums in Grain Commodity Markets. Journal of Agricultural Economics. Forthcoming.
Kopanias K. Αρχαιολογική έρευνα στις θέσεις Tell Nader και Tell Baqrta στην Κουρδική περιφέρεια του βορείου Ιράκ [=Archaeological Research in Tell Nader and in Tell Baqrta in the Kurdistan Region of I. In: Kousoulis P Πρακτικά Συνεδρίου «{EX} {ORIENTE} {LUX}. 1ο Πανελλήνιο Συμπόσιο για την Ερευνα και Διδασκαλία των Πολιτισμών της Αιγύπτου, Εγγύς Ανατολής και Κύπρο. Athens: Papazisis; Forthcoming. Publisher's Version
Antonio G. Δοκιμή. Forthcoming.
Φωτεινός Δημήτρης, Μπουζάκης Σήφης. Η εκπαιδευτική μεταρρύθμιση του 1964: ο διάλογος μέσα από τον Τύπο.; Forthcoming.
Kopanias K. Συστήματα οικονομικής διαχείρισης στη Μεσοποταμία (4η-2η χιλιετία π.Χ.) [=Systems of economic administration in Mesopotamia (4th – 2nd mill. B.C.]. In: Kalogerakou P, Sgouritsa N Τιμητικός τόμος για τον καθηγητή Γεώργιο Στυλ. Κορρέ. Athens; Forthcoming. Publisher's Version
Submitted
Submitted.
Miletic V, Maniadakis D, Mikac B, Varoutas D. 2014 10th International Conference on the Design of Reliable Communication Networks (DRCN). Submitted.
Tselekounis M, Varoutas D, Martakos D. Access Pricing Under Stackelberg Competition: Results Interpretation and Regulatory Implications. Submitted.
Dracopoulos MC, Vlahos N. Approximate Inverse Preconditioning for Multilevel Finite Element Matrices. Submitted.
Dracopoulos MC. Assigning Coordinates to Graphs for Partitioning. Submitted.
Kakaletris G, Varoutas D, Katsianis D, Sphicopoulos T. Biometric Authentication in Broadband Networks for Location-Based Services. Submitted.
Paraskevopoulou P, Saragas N, Stassinopoulou V, Psaroudakis N, Mertis K. Catalytic polymerisation of acetylenes with dinuclear complexes containing metal-metal multiple bonds. Submitted.
Dracopoulos MC. Damping the Effects of Ill-Conditioning in CG Iterations. Submitted.
Kamalakis T, Varoutas D, Sphicopoulos T, Lancis J, Climent V, Caraquitena J, Saavedra G, Mart{\'ınez-Corral M, Andrés P, Wang C, et al. DC Drift of X-Cut LiNbO3 Modulators............... H. Nagata, Y. Li, WR Bosenberg, and GL Reiff 2233 Transverse Bragg-Resonant Enhancement of Modulation and Switching..... W. Liang, Y. Xu, JM Choi, A. Yariv, and W. Ng 2236 Propagation a. Submitted.
Varoutas D, Michalakelis C, Vavoulas A, Deligiorgi K. Diffusion Forecasting and Price Evolution of Broadband Services in Europe. Submitted.
Deligiorgi C, Vavoulas A, Michalakelis C, Varoutas D, Sphicopoulos T. Factors and characteristics affecting ADSL tariffs in Europe. Submitted.
Katsianis D, Varoutas D, Sphicopoulos T, Loizillon F, Harno J, Kalhagen K-O, Stordahl K, Olsen BT, Welling I. Final results on the economic viability of 3G MVNOs. Submitted.
Vlachogiannis E, Viorres N, Bolis S, Neofytou O. THE GREEK UNIVERSITIES INTO THE DIGITAL WORLD—THE U-PORTAL CASE STUDY. Submitted.
Varoutas D, Kamalakis T, Katsianis D, Sphicopoulos T, Monath T, Athens Greece GR15784. Importance of the Maturity of Photonic Component Industry on the Business Prospects of Optical Access Networks: A Techno-economic Analysis. Submitted.
Itescu Y, Schwarz R, Donihue CM, Slavenko A, Roussos SA, Sagonas K, Valakos ED, Foufopoulos J, Pafilis P, Meiri S. Inconsistent patterns of body size evolution in co‐occurring island reptiles. Global Ecology and Biogeography. Submitted.
Konstantinidou AE, Patsouris E, NICOLOPOULOU-STAMATI P. INTRA UTERUS IMPACT OF ENDOCRINE DISRUPTERS. special issue special issue. Submitted:79.
Stavropoulos P, Çelenligil‐Çetin R, Kiani S, Tapper A, Pinnapareddy D, Paraskevopoulou P. Iron, Bis (pyridine) bis (2‐pyridinecarboxylato‐N1, O2). e-EROS Encyclopedia of Reagents for Organic Synthesis. Submitted.
Loizillon F, Harno J, Stordahl K, Welling I, Kalhagen BO, Varoutas D, Katsianis D, Roy J, Borrego DM, de Sousa A. IST-2000-25172 TONIC Deliverable number 11 Final results on seamless mobile IP service provision economics. Submitted.
de Oliveira Duarte M, Stordahl K, Kalhagen KO, Harno J, Elnegaard NK, Olsen BT, Monath T, Ferreira N, Castro E, Pego P, et al. IST-2000-25172 TONIC Deliverable number 8. Submitted.
Chipouras A, CRAIGNOU B, Telecom F, Gavish B, UniZH BS, Zurich ETH, TUM SCMM, Karamti C, Paris ENST, Michalakelis C, et al. Jan Derkacz AGHUniversity of Science and Technology. Submitted.
Michalakelis C, Dede G, Zerva A, Varoutas D, Sphicopoulos T. A methodology for estimating price and diffusion elasticity: an application to telecommunications. Submitted.
Dracopoulos MC. A Multithreaded Finite Element Algorithm with Element-by-Element Preconditioning. Submitted.
Konstantinidou AE. OA CASE REPORTS. Submitted.
Solano F, Pióro M, Pei Y, Zhang X, Xu K, Sun X, Hraimel B, Wu J, Lin J, Marchetto G, et al. Optical Communications and Networking. Submitted.
Coiro A, Listanti M, Valenti A, Matera F, Belmonte A, Kahn JM, Tsubokawa M, Honda N, Azuma Y, Dede G, et al. Optical Communications and Networking. Submitted.
Dracopoulos MC, Glasgow C, Parrott AK, Simkin J. Parallel Performance Prediction for Finite Element Computations. Submitted.
Kouloumentas C, Avramopoulos H, Couris S, Rokkas T, Varoutas D, Vasilopoulou M, Davazoglou D, Pistolis G, Argitis P. Polymer Photonic Technologies for Optical Communications. Submitted.
Varoutas D, Deligiorgi K, Michalakelis C, Sphicopoulos T. Price indexes for telecom market: An application to European market of leased lines. Submitted.
Dracopoulos MC. A Quasi-{N}ewton Approximate Inverse Preconditioner. Submitted.
Patsantaras N, KAMPERIDOU IRENE, PANAGIOTOPOULOS PANAGIOTIS. SOCIAL INCLUSION OR RACISM AND XENOPHOBIA?. Submitted.
Maniadakis D, Varoutas D. Structural properties of urban street networks of varying population density. Proceedings of the 10th European Conference on Complex Systems (ECCS’13) Barcelona. Submitted:1–6.
A System of Systems Framework for the Reliability Assessment of Telecommunications Networks. Submitted.
A System of Systems Framework for the Reliability Assessment of Telecommunications Networks. Submitted.
Stordahl K, Varoutas D. Techno-Economic Evaluation of 3G & WLAN Business Case Feasibility Under Varying Conditions. Submitted.
Katsianis D, Varoutas D, Orfanos I, Sphicopoulos T, Pantelis S. A techno-economic evolutionary path for access technologies. Submitted.
Dede G, Varoutas D, Kamalakis T, Goni G, Javaudin JP. Technological and Socio-Economic Issues Affecting the Deployment of Home Networks: Evidence from the ICT-OMEGA project. Submitted.
Kakaletris G, Varoutas D, Katsianis D, Kouvas G, Zacharopoulos I, Naumanen V, Sarvela H, Zoumpadelis F, Garbi A, Silvennoinen M, et al. User Needs & Market Analysis. M-Guide Deliverable D. Submitted;2.
2018
Kamberidou I. 437 DIRECT CITATIONS – 437 ΑΝΑΦΟΡΕΣ ΑΠΕΥΘΕΙΑΣ ΣΤΟ ΕΡΓΟ. National and Kapodistrian University of Athens]. 2018;(July 7, 2018):1-55.Abstract
  • 437 direct citations since 2003 (updated July 7,  2018)
437  ετεροναφορές/παραπομπές/αναφορές—απευθείας στο έργο— σε επιστημονικά περιοδικά, βιβλία, πρακτικά συνεδρίων, διδακτορικές διατριβές, κ.ά., από το 2003 έως 07/07/2018.
381_direct_citations_updated_may_8_2018.pdf 431_direct_citations_updated_june_19_2018.pdf 437_direct_citations_updated_july_7_2018.pdf
Iliou K, Malenović A, Loukas YL, Dotsikas Y. Analysis of potential genotoxic impurities in rabeprazole active pharmaceutical ingredient via Liquid Chromatography-tandem Mass Spectrometry, following quality-by-design principles for method development. Journal of Pharmaceutical and Biomedical Analysis [Internet]. 2018;149:410-418. Website
Xanthopoulou P, Valakos E, Youlatos D, Nikita E. Assessing the accuracy of cranial and pelvic ageing methods on human skeletal remains from a modern Greek assemblage. [Internet]. 2018. WebsiteAbstract
The present study tests the accuracy of commonly adopted ageing methods based on the morphology of the pubic symphysis, auricular surface and cranial sutures. These methods are examined both in their traditional form as well as in the context of transition analysis using the ADBOU software in a modern Greek documented collection consisting of 140 individuals who lived mainly in the second half of the twentieth century and come from cemeteries in the area of Athens. The auricular surface overall produced the most accurate age estimates in our material, with different methods based on this anatomical area showing varying degrees of success for different age groups. The pubic symphysis produced accurate results primarily for young adults and the same applied to cranial sutures but the latter appeared completely inappropriate for older individuals. The use of transition analysis through the ADBOU software provided less accurate results than the corresponding traditional ageing methods in our sample. Our results are in agreement with those obtained from validation studies based on material from across the world, but certain differences identified with other studies on Greek material highlight the importance of taking into account intra- and inter-population variability in age estimation.
Roshan G, Nastos PT. Assessment of extreme heat stress probabilities in Iran's urban settlements, using first order Markov chain model. Sustainable Cities and Society [Internet]. 2018;36:302-310. Website
Papoutsis K, Kapelouzou A, Tsilimigras DI, Patelis N, Kouvelos G, Schizas D, Karavokyros I, Georgopoulos S. Associations between serum relaxin 2, aneurysm formation/size and severity of atherosclerosis: a preliminary prospective analysis. Acta Pharmacol Sin. 2018.Abstract
Serum relaxin 2 (RL2) is a pleiotropic hormone that acts on various organs and systems, particularly the cardiovascular system. Although RL2 seems to upregulate the synthesis of nitric monoxide (NO) and matrix metalloproteinase (MMP)-2 and -9, current literature on its role in atherosclerosis and aneurysm formation is scarce. The aim of this study was to investigate the levels of serum RL2 in patients with an arterial aneurysm as well as in atherosclerotic patients, and correlate them with the severity of their related vascular disease. A total of 53 subjects were enrolled in this study: 37 patients were scheduled to undergo surgery: 21 patients for different forms of atherosclerotic disease (ATH), 16 patients for an arterial aneurysm (AA), 6 patients for undergoing temporal artery biopsy (TAB), and 10 healthy blood donors (HBD) served as the control groups. RL2 was measured using enzymelinked immunosorbent assay. RL2 was significantly higher in AA patients compared to ATH (P<0.01), TAB (P<0.001) and HBD (P<0.01). No significant difference was found between the ATH and TAB groups (P>0.05). In addition, ATH and AA patients were further subdivided based on the severity of their disease. Serum RL2 was progressively increased in patients with arterial aneurysms, showing a positive relationship with the size of the aneurysmatic dilatation. By contrast, the RL2 level was inversely related to the severity of the atherosclerotic disease. Studies with a larger cohort incorporating a consistent study population are warranted to verify our results and shed light on the mechanistic background of these processes.
Adland E, Hill M, Lavandier N, Csala A, Edwards A, Chen F, Radkowski M, Kowalska JD, Paraskevis D, Hatzakis A, et al. Differential Immunodominance Hierarchy of CD8T-Cell Responses in HLA-B*27:05- and -B*27:02-Mediated Control of HIV-1 Infection. J Virol. 2018;92(4).Abstract
The well-characterized association between HLA-B*27:05 and protection against HIV disease progression has been linked to immunodominant HLA-B*27:05-restricted CD8T-cell responses toward the conserved Gag KK10 (residues 263 to 272) and polymerase (Pol) KY9 (residues 901 to 909) epitopes. We studied the impact of the 3 amino acid differences between HLA-B*27:05 and the closely related HLA-B*27:02 on the HIV-specific CD8T-cell response hierarchy and on immune control of HIV. Genetic epidemiological data indicate that both HLA-B*27:02 and HLA-B*27:05 are associated with slower disease progression and lower viral loads. The effect of HLA-B*27:02 appeared to be consistently stronger than that of HLA-B*27:05. In contrast to HLA-B*27:05, the immunodominant HIV-specific HLA-B*27:02-restricted CD8T-cell response is to a Nef epitope (residues 142 to 150 [VW9]), with Pol KY9 subdominant and Gag KK10 further subdominant. This selection was driven by structural differences in the F pocket, mediated by a polymorphism between these two HLA alleles at position 81. Analysis of autologous virus sequences showed that in HLA-B*27:02-positive subjects, all three of these CD8T-cell responses impose selection pressure on the virus, whereas in HLA-B*27:05-positive subjects, there is no Nef VW9-mediated selection pressure. These studies demonstrate that HLA-B*27:02 mediates protection against HIV disease progression that is at least as strong as or stronger than that mediated by HLA-B*27:05. In combination with the protective Gag KK10 and Pol KY9 CD8T-cell responses that dominate HIV-specific CD8T-cell activity in HLA-B*27:05-positive subjects, a Nef VW9-specific response is additionally present and immunodominant in HLA-B*27:02-positive subjects, mediated through a polymorphism at residue 81 in the F pocket, that contributes to selection pressure against HIV.CD8T cells play a central role in successful control of HIV infection and have the potential also to mediate the eradication of viral reservoirs of infection. The principal means by which protective HLA class I molecules, such as HLA-B*27:05 and HLA-B*57:01, slow HIV disease progression is believed to be via the particular HIV-specific CD8T cell responses restricted by those alleles. We focus here on HLA-B*27:05, one of the best-characterized protective HLA molecules, and the closely related HLA-B*27:02, which differs by only 3 amino acids and which has not been well studied in relation to control of HIV infection. We show that HLA-B*27:02 is also protective against HIV disease progression, but the CD8T-cell immunodominance hierarchy of HLA-B*27:02 differs strikingly from that of HLA-B*27:05. These findings indicate that the immunodominant HLA-B*27:02-restricted Nef response adds to protection mediated by the Gag and Pol specificities that dominate anti-HIV CD8T-cell activity in HLA-B*27:05-positive subjects.
Mirza SB, Lee RCH, Chu JJH, Salmas RE, Mavromoustakos T, Durdagi S. Discovery of selective dengue virus inhibitors using combination of molecular fingerprint-based virtual screening protocols, structure-based pharmacophore model development, molecular dynamics simulations and in vitro studies. Journal of Molecular Graphics and Modelling [Internet]. 2018;79:88 - 102. Website
Arabatzis T. Spontaneous Generations: A Journal for the History and Philosophy of Science [Internet]. 2018;9(1):35-37.
I raise two challenges for scientific realists. The first is a pessimistic meta-induction (PMI), but not of the more common type, which focuses on rejected theories and abandoned entities. Rather, the PMI I have in mind departs from conceptual change, which is ubiquitous in science. Scientific concepts change over time, often to a degree that is difficult to square with the stability of their referents, a sine qua non for realists. The second challenge is to make sense of successful scientific practice that was centered on entities that have turned out to be fictitious.
2018a.pdf
Lodi S, Günthard HF, Dunn D, Garcia F, Logan R, Jose S, Bucher HC, Scherrer AU, Schneider M-P, Egger M, et al. Effect of immediate initiation of antiretroviral treatment on the risk of acquired HIV drug resistance. AIDS. 2018;32(3):327-335.Abstract
OBJECTIVE: We estimated and compared the risk of clinically identified acquired drug resistance under immediate initiation [the currently recommended antiretroviral therapy (ART) initiation strategy], initiation with CD4 cell count less than 500 cells/μl and initiation with CD4 cell count less than 350 cells/μl. DESIGN: Cohort study based on routinely collected data from the HIV-CAUSAL collaboration. METHODS: For each individual, baseline was the earliest time when all eligibility criteria (ART-naive, AIDS free, and others) were met after 1999. Acquired drug resistance was defined using the Stanford classification as resistance to any antiretroviral drug that was clinically identified at least 6 months after ART initiation. We used the parametric g-formula to adjust for time-varying (CD4 cell count, HIV RNA, AIDS, ART regimen, and drug resistance testing) and baseline (calendar period, mode of acquisition, sex, age, geographical origin, ethnicity and cohort) characteristics. RESULTS: In 50 981 eligible individuals, 10% had CD4 cell count more than 500 cells/μl at baseline, and 63% initiated ART during follow-up. Of 2672 tests for acquired drug resistance, 794 found resistance. The estimated 7-year risk (95% confidence interval) of acquired drug resistance was 3.2% (2.8,3.5) for immediate initiation, 3.1% (2.7,3.3) for initiation with CD4 cell count less than 500 cells/μl, and 2.8% (2.5,3.0) for initiation with CD4 cell count less than 350 cells/μl. In analyses restricted to individuals with baseline in 2005-2015, the corresponding estimates were 1.9% (1.8, 2.5), 1.9% (1.7, 2.4), and 1.8% (1.7, 2.2). CONCLUSION: Our findings suggest that the risk of acquired drug resistance is very low, especially in recent calendar periods, and that immediate ART initiation only slightly increases the risk. It is unlikely that drug resistance will jeopardize the proven benefits of immediate ART initiation.
Chatoupis C, Vagenas G. Effectiveness of the practice style and the reciprocal style of teaching: a meta-analysis. The Physical Educator [Internet]. 2018;75(2). Publisher's VersionAbstract
The purpose of this meta-analysis was to examine the effectiveness of Mosston and Ashworth’s (2008) practice and reciprocal styles of teaching on motor skill acquisition of school and university students. A systematic search in bibliographical databases led to the identification of 23 relevant studies published in peer-reviewed journals. Using certain methodological and statistical criteria, we retained six studies for further analysis. We estimated proper Effect Size (ES) statistics for each study and each teaching style. Heterogeneity of the ESs was almost negligence for the reciprocal style and moderate to large for the practice style (I2 > 50%). Both teaching styles appear to produce rather large effects, with the practice style (mean d = 1.16) having larger effects than the reciprocal style (mean d = 0.94). This meta-analysis provides an overview and synthesis of relevant studies and highlights both teaching styles for increasing K-12 and university students’ motor skill learning. The results are discussed in light of the Spectrum theory.   Keywords: meta-analysis, Spectrum, practice style, reciprocal style, motor skill
chatoupis_vagenas_2018.pdf
<em>Landscapes of Disease: Malaria in Modern Greece</em>
Gardikas K. Landscapes of Disease: Malaria in Modern Greece. Budapest, New York: Central European University Press; 2018.Abstract
Malaria existed in Greece since prehistoric times. Its prevalence fluctuated depending on climatic, socioeconomic and political changes. The book focuses on the factors that contributed to the spreading of the disease in the years between independent statehood in 1830 and the elimination of malaria in the 1970s. By the nineteenth century, Greece was the most malarious country in Europe and the one most heavily infected with its lethal form, falciparum malaria. Owing to pressures on the environment from economic development, agrarian colonization and heightened mobility, the situation became so serious that malaria became a routine part of everyday life for practically all Greek families, further exacerbated by wars. The country’s highly fragmented geography and its variable rainfall distribution created an environment that was ideal for sustaining and spreading the disease. These factors, in turn, affected the tolerance of the population to malaria. In their struggle with physical suffering and death, the Greeks developed a culture of avid quinine consumption and were likewise eager to embrace the DDT spraying campaign of the immediate post WWII years, which, overall, had a positive demographic effect.ContentsIntroduction Chapter 1: Malaria: An Ancient and Global Disease Chapter 2: The Fragmented Geography of the Disease Chapter 3: Malaria in Peace and War Chapter 4: Patients, Doctors, and Cures Conclusion
Karavokyros I, Michalinos A. Favoring D-Lymphadenectomy in Gastric Cancer. Front Surg. 2018;5:42.Abstract
The role of extended lymphadenectomy in the surgical treatment of gastric cancer has been debated for many years. So far six prospective randomized trials and a number of meta-analyses comparing D- to D-lymphadenectomy in open surgery have been published with contradicting results. The possible oncologic benefit of radical lymphadenectomy has been blurred by a number of reasons. In most of the trials the strategies under comparison were made similar after protocol violations. Imperfect design of the trials could not exclude the influence of cofounding factors. Inappropriate endpoints could not detect evidently the difference between the two surgical strategies. On the other hand radical lymphadenectomy was characterized by increased morbidity and mortality. This was mostly caused by the addition of pancreatico-splenectomy in all D-dissections, even when not indicated. A careful analysis of the available evidence indicates that D-lymphadenectomy performed by adequately trained surgeons without resection of the pancreas and/or spleen, unless otherwise indicated, decreases Gastric Cancer Related Deaths and increases Disease Specific Survival. This evidence is not compelling but cannot be ignored. D-lymphadendctomy is nowadays considered to be the standard of care for resectable gastric cancer.
Kamberidou I. Frédéric Barbier, The Greek Dream by Monsieur de Choiseul: The Travels of a European of the Enlightenment. [Review of the Book: Le rêve grec de Monsieur de Choiseul Les voyages d'un européen des Lumières by Frédéric Barbier]. Journal of Modern Greek Studies (Print ISSN: 0738-1727, Online ISSN: 1086-3265) [Internet]. 2018;35:564–612. Publisher's VersionAbstract
John Hopkins University Press:  (PROJECT MUSE: https://muse.jhu.edu/article/671081) Irene Kamberidou (2017). Journal of Modern Greek StudiesVolume 35, Number 2, October 2017, pp. 564-570 | 10.1353/mgs.2017.0031       [[Praised as "a magnificent scholarly journal" by Choice magazine, Journal of Modern Greek Studies is the only scholarly periodical to focus exclusively on modern Greece. The Journal publishes critical analyses of Greek social, cultural, and political affairs, covering the period from the late Byzantine Empire to the present. Contributors include internationally recognized scholars in the fields of history, literature, anthropology, political science, Byzantine studies, and modern Greece. Journal of Modern Greek Studies is the official publication of the Modern Greek Studies Association (MGSA).]]..............ARTICLE CITATION:  Kamberidou, Irene (2017). Frédéric Barbier, The Greek Dream by Monsieur de Choiseul: The Travels of a European of the Enlightenment. [Review of the Book:  Le rêve grec de Monsieur de Choiseul Les voyages d'un européen des Lumières by Frédéric Barbier] Journal of Modern Greek Studies 35 (2017) 564–612 © 2017 by The Modern Greek Studies Association. Print ISSN: 0738-1727,  Online ISSN:  1086-3265. John Hopkins University Press: https://www.p     ***** The Greek Dream by Monsieur de Choiseul: The Travels of a European of the Enlightenment by Frédéric Barbier Journal Article published 2017 in Journal of Modern Greek Studies volume 35 issue 2 on pages 564 to 570 Author: Irene Kamberidou  https://doi.org/10.1353/mgs.2017.0031  , John Hopkins University Press
the_greek_dream.pdf
Pineda-Peña A-C, Theys K, Stylianou DC, Demetriades I, Abecasis AB, Kostrikis LG. HIV-1 Infection in Cyprus, the Eastern Mediterranean European Frontier: A Densely Sampled Transmission Dynamics Analysis from 1986 to 2012. Sci Rep. 2018;8(1):1702.Abstract
Since HIV-1 treatment is increasingly considered an effective preventionstrategy, it is important to study local HIV-1 epidemics to formulate tailored preventionpolicies. The prevalence of HIV-1 in Cyprus was historically low until 2005. To investigatethe shift in epidemiological trends, we studied the transmission dynamics of HIV-1 in Cyprususing a densely sampled Cypriot HIV-1 transmission cohort that included 85 percent ofHIV-1-infected individuals linked to clinical care between 1986 and 2012 based on detailedclinical, epidemiological, behavioral and HIV-1 genetic information. Subtyping andtransmission cluster reconstruction were performed using maximum likelihood and Bayesianmethods, and the transmission chain network was linked to the clinical, epidemiological andbehavioral data. The results reveal that for the main HIV-1 subtype A1 and B sub-epidemics,young and drug-naïve HIV-1-infected individuals in Cyprus are driving the dynamics of thelocal HIV-1 epidemic. The results of this study provide a better understanding of thedynamics of the HIV-1 infection in Cyprus, which may impact the development of preventionstrategies. Furthermore, this methodology for analyzing densely sampled transmissiondynamics is applicable to other geographic regions to implement effective HIV-1 preventionstrategies in local settings.
Arabatzis T. How Physica Became Physics: Review of J. L. Heilbron, Physics: A Short History from Quintessence to Quarks (Oxford: Oxford University Press, 2015). Science & Education [Internet]. 2018;27:211-218. Publisher's Version
Bertsatos A, Papageorgopoulou C, Valakos E, Chovalopoulou M-E. Investigating the sex-related geometric variation of the human cranium. International Journal of Legal Medicine [Internet]. 2018. WebsiteAbstract
Accurate sexing methods are of great importance in forensic anthropology since sex assessment is among the principal tasks when examining human skeletal remains. The present study explores a novel approach in assessing the most accurate metric traits of the human cranium for sex estimation based on 80 ectocranial landmarks from 176 modern individuals of known age and sex from the Athens Collection. The purpose of the study is to identify those distance and angle measurements that can be most effectively used in sex assessment. Three-dimensional landmark coordinates were digitized with a Microscribe 3DX and analyzed in GNU Octave. An iterative linear discriminant analysis of all possible combinations of landmarks was performed for each unique set of the 3160 distances and 246,480 angles. Cross-validated correct classification as well as multivariate DFA on top performing variables reported 13 craniometric distances with over 85% classification accuracy, 7 angles over 78%, as well as certain multivariate combinations yielding over 95%. Linear regression of these variables with the centroid size was used to assess their relation to the size of the cranium. In contrast to the use of generalized procrustes analysis (GPA) and principal component analysis (PCA), which constitute the common analytical work flow for such data, our method, although computational intensive, produced easily applicable discriminant functions of high accuracy, while at the same time explored the maximum of cranial variability.
Christofi A, Stefanou N. Metal-coated magnetic nanoparticles in an optically active medium: A nonreciprocal metamaterial. Physical Review B. 2018;97(12):125129 (7 pages).Abstract
We report on the optical response of a nonreciprocal bianisotropic metamaterial, consisting of spherical, metal-coated magnetic nanoparticles embedded in an optically active medium, thus combining gyrotropy, plasmonic resonances, and chirality in a versatile design. The corresponding effective medium is deduced by an appropriate two-step generalized Maxwell-Garnett homogenization scheme. The associated photonic band structure and transmission spectra are obtained through a six-vector formulation of Maxwell equations, which provides an efficient framework for general bianisotropic structures going beyond existing approaches that involve cumbersome nonlinear eigenvalue problems. Our results, analyzed and discussed in the light of group theory, provide evidence that the proposed metamaterial exhibits some remarkable frequency-tunable properties, such as strong, plasmon-enhanced nonreciprocal polarization azimuth rotation and magnetochiral dichroism.
Vasylyeva TI, Liulchuk M, Friedman SR, Sazonova I, Faria NR, Katzourakis A, Babii N, Scherbinska A, Thézé J, Pybus OG, et al. Molecular epidemiology reveals the role of war in the spread of HIV in Ukraine. Proc Natl Acad Sci U S A. 2018;115(5):1051-1056.Abstract
Ukraine has one of the largest HIV epidemics in Europe, historically driven by people who inject drugs (PWID). The epidemic showed signs of stabilization in 2012, but the recent war in eastern Ukraine may be reigniting virus spread. We investigated the movement of HIV-infected people within Ukraine before and during the conflict. We analyzed HIV-1 subtype-Anucleotide sequences sampled during 2012-2015 from 427 patients of 24 regional AIDS centers and used phylogeographic analysis to reconstruct virus movement among different locations in Ukraine. We then tested for correlations between reported PWID behaviors and reconstructed patterns of virus spread. Our analyses suggest that Donetsk and Lugansk, two cities not controlled by the Ukrainian government in eastern Ukraine, were significant exporters of the virus to the rest of the country. Additional analyses showed that viral dissemination within the country changed after 2013. Spearman correlation analysis showed that incoming virus flow was correlated with the number of HIV-infected internally displaced people. Additionally, there was a correlation between more intensive virus movement and locations with a higher proportion of PWID practicing risky sexual behaviors. Our findings suggest that effective prevention responses should involve internally displaced people and people who frequently travel to war-affected regions. Scale-up of harm reduction services for PWID will be an important factor in preventing new local HIV outbreaks in Ukraine.
Καμπερίδου Ειρήνη.

Ψηφιακές Δεξιότητες και Ψηφιακό Χάσμα: Εισάγοντας τη διάσταση του φύλου

. 6ο ΣΥΝΕΔΡΙΟ ΤΗΣ ΕΛΛΗΝΙΚΗΣ ΚΟΙΝΩΝΙΟΛΟΓΙΚΗΣ ΕΤΑΙΡΕΙΑΣ «Η Κοινωνιολογία και ο Δημόσιος Ρόλος της στην Εποχή της Μεταμόρφωσης του Κόσμου», HELLENIC SOCIOLOGICAL SOCIETY (HSS). 2018;(30/03/2018).Abstract
Ο ψηφιακός εγγραμματισμός λειτουργεί ως εξαιρετικό μέσον για την ισόνομη μεταχείριση και πλήρη ενσωμάτωση κοινωνικά αποκλεισμένων ομάδων στην κοινωνία της πληροφορίας. Προβαίνοντας σε μια ανάλυση των πρόσφατων ερευνών και συζητήσεων για το ψηφιακό χάσμα, τις απαιτούμενες σήμερα ψηφιακές δεξιότητες και τη μελλοντική ζήτηση, αυτή η μελέτη επικεντρώνεται στην έμφυλη διάσταση. Ερευνητικά δεδομένα επιβεβαιώνουν ότι δεκαετίες προτάσεων και παρεμβάσεων—ερευνητικών, πολιτικών, κοινωνικών, νομοθετικών—δεν αύξησαν τη γυναικεία συμμετοχή σε κλάδους STEM (Φυσικές Επιστήμες, Τεχνολογία, Επιστήμη των Μηχανικών, Μαθηματικά) και ΤΠΕ (Τεχνολογίες της Πληροφορίας και Επικοινωνίας). Οι γυναίκες αποτελούν αόρατη μειονότητα σε αυτούς τους τομείς, παρά τις ενέργειες του κινήματος για την κοινωνική ενσωμάτωση/ένταξη των γυναικών και κοριτσιών στις ΤΠΕ και την ευρεία αναγνώριση της σημαντικότητας των ψηφιακών δεξιοτήτων που απαιτούνται σήμερα στους χώρους εργασίας της Ευρωπαϊκής Ένωσης. Τα αποτελέσματα εμπειρικών ερευνών αναδεικνύουν τη ζωτική σημασία αναμόρφωσης της εκπαίδευσης STEM ώστε να συμπεριλάβει την έμφυλη διάσταση, δεδομένου ότι οι κοινωνικές προκαταλήψεις ξεκινούν από μικρή ηλικία. Επισημαίνεται, επίσης και η  αναγκαιότητα να καθορισθούν και να καταγραφούν από τους βιομηχανικούς θεσμούς οι πραγματικές ανάγκες, οι συγκεκριμένες απαιτήσεις και ψηφιακές δεξιότητες που απαιτούνται σήμερα. Η μελέτη αυτή ολοκληρώνεται με τις αφηγήσεις ζωής και πολύτιμες συμβουλές διακεκριμένων γυναικών στην κοινωνία της πληροφορίας και των ΤΠΕ.    Λέξεις κλειδιά: ψηφιακό χάσμα, φύλο, έμφυλη υποτίμηση (devaluation), ψηφιακές δεξιότητες, ψηφιακός εγγραμματισμός μαθητών/τριών, πληροφορικός γραμματισμός    
eke_conference_draft_program.pdf eke_conf_2018_programme_book.pdf sociology_in_times_of_crisis_certificate_certification-vevaiosi.pdf
Kefi Chatzichamperi E, Kamberidou I, Patsantaras N.

Προωθώντας την Έμφυλη Ουδετερότητα στις Ένοπλες Δυνάμεις δια της Κοινής Συμμετοχής Ανδρών και Γυναικών σε Αθλητικές Δραστηριότητες

. In: 6ο ΣΥΝΕΔΡΙΟ ΤΗΣ ΕΛΛΗΝΙΚΗΣ ΚΟΙΝΩΝΙΟΛΟΓΙΚΗΣ ΕΤΑΙΡΕΙΑΣ «Η κοινωνιολογία και ο δημόσιος ρόλος της στην εποχή της μεταμόρφωσης του κόσμου», Ενότητα: ΕΝΟΠΛΕΣ ΔΥΝΑΜΕΙΣ ΚΑΙ ΚΟΙΝΩΝΙΟΛΟΓΙΑ. Χαροκόπειο Πανεπιστήμιο, Αθήνα : ΕΛΛΗΝΙΚΗ ΚΟΙΝΩΝΙΟΛΟΓΙΚΗ ΕΤΑΙΡΕΙΑ (ΕΚΕ) – HELLENIC SOCIOLOGICAL SOCIETY (HSS); 2018.Abstract
PROMOTING A GENDER NEUTRAL-INCLUSIVE MILITARY SOCIETY THROUGH COED SPORTS...... Abstract This study examines women’s inclusion in the Armed Forces in Greece, a traditionally male-dominated social space. It discusses women’s participation in all three sectors of the Armed Forces— administrative and institutional posts—as opposed to their past engagement in secondary, subordinate or unofficial roles, i.e. war nurses and volunteers. Despite women’s entry—in the last three decades—research indicates they experience gender discrimination in many areas of the male-centric and hierarchal structures of the Armed Forces. This pilot study shows that participation in sport activities with men reduces social discrimination related to gender. It explores how coed sports (joint sport participation) in the education programs of the Hellenic Armed Forces contributes to changing gender stereotypes and promoting "gender neutrality" (Kamberidou 2012), namely "a gender-neutral inclusive" military society (Kamberidou & Patsantaras 2005), consequently reducing gender discrimination and encouraging respect for diversity. The findings also show that the coed sport programs and activities promote women’s acceptance by their male colleagues, including trust, team effectiveness, team spirit, collaboration, empathy, problem-solving skills, and self-esteem.  Key words: Gender Neutrality, Women, Sport, Armed Forces ΠΡΟΩΘΩΝΤΑΣ ΤΗΝ ΕΜΦΥΛΗ ΟΥΔΕΤΕΡΟΤΗΤΑ ΣΤΙΣ ΕΝΟΠΛΕΣ ΔΥΝΑΜΕΙΣ ΔΙΑ ΤΗΣ ΚΟΙΝΗΣ ΣΥΜΜΕΤΟΧΗΣ ΑΝΔΡΩΝ ΚΑΙ ΓΥΝΑΙΚΩΝ ΣΕ ΑΘΛΗΤΙΚΕΣ ΔΡΑΣΤΗΡΙΟΤΗΤΕΣ ......ΠΕΡΙΛΗΨΗΟι δυνατότητες πρόσβασης των γυναικών στις Ένοπλες Δυνάμεις στην ελληνική επικράτεια, υπό την έννοια ανάληψης διοικητικής ή άλλης μορφής θεσμικής ευθύνης,  είναι ένα φαινόμενο των τριών τελευταίων δεκαετιών. Ο χώρος των Ενόπλων Δυνάμεων παραδοσιακά χαρακτηρίζονταν ως ένας ανδροκεντρικός χώρος, με τον οποίο οι γυναίκες σχετίζονταν μόνο επικουρικά, αναλαμβάνοντας βοηθητικούς ρόλους, κυρίως σε περιόδους πολεμικών συρράξεων. Σήμερα όμως  πολλές γυναίκες στελεχώνουν και τους τρεις κλάδους των Ενόπλων Δυνάμεων: Στρατό Ξηράς, Πολεμική Αεροπορία και Πολεμικό ναυτικό. Ωστόσο σε έρευνες επισημαίνεται ότι πολλές φορές οι γυναίκες δεν απολαμβάνουν ισόνομη μεταχείριση και  υφίστανται ποικίλες διακρίσεις  σε αυτές τις κοινωνικές περιοχές. Ερευνητικά δεδομένα επίσης υποστηρίζουν, ότι η συμμετοχή ανδρών και γυναικών σε κοινές αθλητικές δραστηριότητες, λειτουργεί καταλυτικά στην άμβλυνση αρνητικών παραδοσιακών στερεοτύπων που συνδέονται γενικά με την δραστηριοποίηση της γυναίκας σε χώρους που παραδοσιακά θεωρούνταν ανδροκεντρικοί. Η μελέτη αυτή είναι μια πιλοτική μελέτη περίπτωσης,  η οποία λαμβάνοντας υπ’ όψιν τη σχετική με τα ζητήματα αυτά βιβλιογραφία, διερευνά κατά πόσον η κοινή συμμετοχή σε αθλητικές δραστηριότητες που συντελούνται στα προγράμματα εκπαίδευσης των Ενόπλων Δυνάμεων, μπορεί να συντελέσει στην προώθηση αντιλήψεων και στάσεων οι οποίες μπορούν να προάγουν και να ενεργοποιήσουν μια έμφυλη ουδετερότητα (Kamberidou, 2011, Καμπερίδου 2012). Τα αποτελέσματα δείχνουν ότι η συμμετοχή των γυναικών σε κοινά αθλητικά προγράμματα των Ενόπλων Δυνάμεων, προάγει την αυτό-εκτίμηση τους, την αποδοχή τους από τους άνδρες συναδέλφους, αλλά και την ομαδική αποτελεσματικότητα και την παγίωση κλίματος εμπιστοσύνης μεταξύ των φύλων.         
eke_conf_2018_programme_book.pdf
Tsokos Α, Kotsi Ε, Petrakis S, Vassilakis E.

Combining series of multi-source high spatial resolution remote sensing datasets for the detection of shoreline displacement rates and the effectiveness of coastal zone protection measures

. Journal of Coastal Conservation [Internet]. 2018. pdfAbstract
The long-term change of the shoreline location is a phenomenon, which is highly factored in the design of construction projects along the coastal zone. Especially, beach erosion is characterized as one of the major problems at coastal areas and it is of high importance as a quite significant percentage of social development is concentrated in a relatively narrow zone not far from the waterfront. This study presents a methodology that aims to quantify the shoreline displacement rate by involving the processing of different types of remote sensing datasets such as aerial photographs, satellite images and unmanned aerial system data coupled with in-situ observations and measurements. Several photogrammetric techniques were used in order to orthorectify and homogenize a time series of remotely sensed data acquired from 1945 to 2017, representing a rapidly relocating coastal zone at the southern part of Corinth Gulf (Greece), as a case study. All images were digitally processed and optically optimized in order to produce a highly accurate representation of the shoreline at the time period of each acquisition. The data were imported in a Geographic Information System platform, where they were subjected to comparison and geostatistical analysis. High erosion rates were calculated, reaching the order of 0.18 m/year on average whilst extreme rates of 0.70 m/year were also observed in specific locations leading to the segmentation of the coastal zone according to its vulnerability and consequently the risk for further development as well as the effectiveness of measures already taken by the authorities. 
Chrysafis I, Christopoulou A, Kazanis D, Farangitakis G-P, Mallinis G, Mitsopoulos I, Arianoutsou M, Emm. V, Antoniou V, Theofanous N, et al.

Post-fire vegetation recovery mapping using multi-temporal Sentinel-2A imagery in Chios island, Greece

. EGU 2018-7452. 2018.Abstract
Remote sensing techniques offer the opportunity to study fire effects and vegetation recovery dynamics across large areas, providing essential information for effective management strategies development over fire-prone landscapes. Chios, the fifth largest of the Greek islands, has experienced recurring forest fires during the recent years, resulting to significant risk of environmental degradation. During the summer of 2016, the island experienced two severe wildfires, with the biggest one recorded in the southern part of the island. The affected area was mostly covered by maquis and phrygana (formations of low shrubs) (40.9%), while pine forests (Pinus brutia) represented 15.5% of the burned area. The aim of this study was to estimate and analyze the state of post-fire vegetation recovery in the island of Chios following major fire events occurred during the summer of 2016. A post-fire 8-band WorldView-2 image was used for burned area mapping by employing a geographic object-based classification approach, followed by field campaign for assessing post fire vegetation recovery, which was conducted during summer 2017 by establishing reference plots in the main pre-fire vegetation types (maquis, shrublands and pine forest areas) within the fire-affected area. A series of single and multi-temporal spectral indices including Normalized Burn Ratio, Normalized Difference Vegetation Index, Enhanced Vegetation Index and Soil Adjusted Vegetation Index, were derived from multi-temporal Sentinel-2 images. A random forest modelling procedure was performed for estimating post fire vegetation recovery within the burned area, as well as the areas of high risk erosion. We identified dNDVI, EVI and the second red edge band of Sentinel-2 as the most important spectral variables for predicting vegetation recovery within pre-fire areas. In the case of pre-fire areas with maquis, post-fire NBR, EVI and NDVI were selected as best predictors. Finally, the results revealed that vegetation recovery is more pronounced within the pre-fire pine forest areas, while topographic and geological sub-strata factors were also found significant in defining post-fire vegetation recovery.
Kamberidou I.

BRANDING HERITAGE: ANCIENT GREEK CULTURE THROUGH CONTEMPORARY DESIGN

. CONTEMPORARY MINOANS, 12-13 May 2018, Crete. 2018.Abstract
Cultural Organization Branding Heritage (BH)-Προσκεκλημένη (ως Branding Heritage Expert) στο Διήμερο Συμπόσιο Πολιτισμού Contemporary Minoans “Μινωικός Πολιτισμός Εμπνέει Σύγχρονες Δημιουργίες", 12-13 Μαίου 2018, Κρήτη (υπό την Αιγίδα του Υπουργείου Πολιτισμού και Αθλητισμού, του Υπουργείο Πολιτισμού, την Περιφέρεια Κρήτης, British School at Athens,  κ.ά.):
  • Επισυνάπτεται  (1) Πρόγραμμα,  
  • (2) επισυνάπτεται επίσης αρθρογραφία της Ειρήνης Καμπερίδου (Irene Kamberidou) για τον ΠΟΛΙΤΙΣΜΟ ΤΟΥ ΣΩΜΑΤΟΣ ΚΑΙ Ο ΠΟΛΙΤΙΣΜΟΣ ΤΟΥ ΦΑΓΗΤΟΥ-Η ΜΑΓΕΙΡΙΚΗ ΤΕΧΝΗ ΣΤΗΝ ΑΡΧΑΙΑ ΕΛΛΑΔΑ (ΜΟΔΑ, ΕΝΔΥΣΗ, ΥΠΟΔΗΜΑΤΑ, ΑΡΩΜΑΤΑ ΤΩΝ ΑΡΧΑΙΟΝ ΕΛΛΗΝΩΝ [Fashions (what they wore and how), footwear (sandals, boots),  Cosmetics, aromas/Perfumes/scents, Hairstyles and in Ancient Greece].
branding_heritage_program_may_12-13_2018.pdf 1._antique_fashion_is_never_too_old.the_art_of_cooking_dining_in_ancient_greece.pdf
Kamberidou I, Karteroliotis K, Venetsanou F.

DISSEMINATION BY GREEK TEAM: THOUSANDS REACHED

. Athens: National and Kapodistrian University of Athens; 2018 pp. 1-16. Publisher's VersionAbstract
Dissemination report - Over 3, 450 reached to date that can be counted, in addition to those we have not counted or estimated, such as the uploads in over 10 websites, social media, networks, databases and homepages accessed, reached or visited by thousands, e.g. https://en.uoa.gr, as well as faculty emails and discussion folders/conversation pages (DEP and SOC), open access e-classes and project partners Facebook shares, to name a few. This report also includes a sample photo of our students linking into GeoLudens (See: Creating a tech tool to promote European Traditional Sports and Games from an intergenerational and inclusive perspective, ERASMUS PLUS Small Collaborative Partnership-GEO-LUDENS) © Kamberidou, I; Karteroliotis, K.; Venetsanou, F. (8/6/2018). Dissemination by Greek Team - Thousands Reached. School of Physical Education and Sport Science, National and Kapodistrian University of Athens (NKUA). Dissemination report following GEO-LUDENS (579689-EPP-1-2016-1-ES-SPO-SSCP) five working sessions in Athens, Greece, May 30/31-June 1, 2018.
2._dissemination_by_greek_team_june_8_2018.pdf 2.1._nkua.pdf
Moissette P, Cornee, J.-J., Antonarakou, A., Kontakiotis, G., Drinia, H., KOSKERIDOU, E., Tsourou, T., Agiadi, K., Karakitsios V. Palaeoenvironmental changes at the Tortonian/Messinian boundary: A deep-sea sedimentary record of the eastern Mediterranean Sea. Palaeogeography, Palaeoclimatology, Palaeoecology [Internet]. 2018;505:217-233. Publisher's Version
Mitsi E. "Performing Massacre". Gramma: Journal of Theory and Criticism [Internet]. 2018;24 (2017). Publisher's VersionAbstract
Christopher Marlowe's The Massacre at Paris, a play which probably dates from 1592 but has reached posterity in a mangled form, enacts the incorporation of religious and state politics in the theatre. Through a sequence of short scenes characterized by senseless brutality and black humor, Marlowe revisits one of the darkest episodes of French history, the Saint Bartholomew‘s Day Massacre, which took place on the 24th and 25thAugust 1572. Dramatizing the slaughter of thousands of Protestants by Catholics, the play not only reflects on the significance of massacre as a political term for an increasingly absolutist Renaissance Europe but also translates the violence of massacre into aesthetic form. Itself alien within the body of Marlowe’s dramatic works, The Massacre at Paris has rarely been performed after its Elizabethan successful performances at the Rose; this is not surprising given the state of the extant text and its dismissal by many critics as crude anti-Catholic propaganda. Yet, the Massacre's corrupt and incomplete form, political ambiguities and emphasis on theatrical violence have inspired two contemporary artists, the French director Guillaume Delaveau and the Austrian composer Wolfgang Mitterer, to rethink and revive it. Both Delaveau's Massacre à Paris, first performed at Toulouse in 2007 and Mitterer's experimental opera Massacre, composed in 2003 and performed in 2008 and 2010 in France, refer to recent wars and atrocities and rejoice in the irony of the play. This paper seeks to investigate the play's ability to convey political thought and provoke contemporary audiences by reading it together with Delaveau and Mitterer's adaptations. The challenge of reworking the Massacre for our age involves the question of the theatre's potential to expose the audience to the horror of history.
Antonarakou A, Kontakiotis G, Zarkogiannis S, Mortyn PG, DRINIA H, Koskeridou E, ANASTASAKIS G. Planktonic foraminiferal abnormalities in coastal and open marine eastern Mediterranean environments: A natural stress monitoring approach in recent and early Holocene marine systems. Journal of Marine Systems [Internet]. 2018;181:63-78. Publisher's Version
Marinova E, Harrison SP, Bragg F, Connor S, de Laet V, Leroy SA, Mudie P, Atanassova J, Bozilova E, Caner H, et al. Pollen-derived biomes in the Eastern Mediterranean-Black Sea-Caspian-Corridor. Journal of Biogeography [Internet]. 2018;45(2):484-499. Publisher's VersionAbstract
Aim: To evaluate the biomization technique for reconstructing past vegetation in the Eastern Mediterranean–Black Sea–Caspian-Corridor using an extensive modern pollen data set and comparing reconstructions to potential vegetation and observed land cover data. Location: The region between 28–48°N and 22–62°E. Methods: We apply the biomization technique to 1,387 modern pollen samples, representing 1,107 entities, to reconstruct the distribution of 13 broad vegetation categories (biomes). We assess the results using estimates of potential natural vegetation from the European Vegetation Map and the Physico-Geographic Atlas of the World. We test whether anthropogenic disturbance affects reconstruction quality using land use information from the Global Land Cover data set. Results: The biomization scheme successfully predicts the broadscale patterns of vegetation across the region, including changes with elevation. The technique discriminates deserts from shrublands, the prevalence of woodlands in moister lowland sites, and the presence of temperate and mixed forests at higher elevations. Quantitative assessment of the reconstructions is less satisfactory: the biome is predicted correctly at 44% of the sites in Europe and 33% of the sites overall. The low success rate is not a reflection of anthropogenic impacts: only 33% of the samples are correctly assigned after the removal of sites in anthropogenically altered environments. Open vegetation is less successfully predicted (33%) than forest types (73%), reflecting the under-representation of herbaceous taxa in pollen assemblages and the impact of long-distance pollen transport into open environments. Samples from small basins ( < 1 km 2 ) are more likely to be reconstructed accurately, with 58% of the sites in Europe and 66% of all sites correctly predicted, probably because they sample an appropriate pollen source area to reflect regional vegetation patterns in relatively heterogeneous landscapes. While methodological biases exist, the low confidence of the quantitative comparisons should not be over-emphasized because the target maps themselves are not accurate representations of vegetation patterns in this region. Main Conclusions: The biomization scheme yields reasonable reconstructions of the broadscale vegetation patterns in the Eastern Mediterranean–Black Sea–Caspian-Corridor, particularly if appropriate-sized sampling sites are used. Our results indicate biomization could be used to reconstruct changing patterns of vegetation in response to past climate changes in this region.
Antoniou V, Mavroulis S, Theocharis D, Skourtsos E, Vassilakis E, Lekkas E. Post-fire landslide susceptibility mapping in the 2016 fire-affected areas of Chios Island (Northeastern Aegean Sea, Greece). EGU2018-7452. 2018;19.Abstract
n July 25 and August 26 2016 wildfires broke out in the southwestern and central-western part of Chios Island(NE Aegean Sea, Greece), respectively. The first affected an area of approximately 47km2 and burned throughalmost 90% of olive groves and mastic trees, while the second broke out in a forested area and affected approximately6.6km2 of forest and farmland.A research aiming at the post-fire landslide susceptibility (LS) mapping of both areas was conducted. Morphologicaldata (slope, aspect, curvature, drainage network) derived from a 5m-DEM model of the areas was used.Lithological and geological data (lithology, tectonic structures) were digitized from previous field work maps.Land cover was derived from Worldview-2 satellite images before and after the fire events. Soil thickness was derivedfrom field survey observations within the fire-affected areas, road network from OpenStreetMap and rainfalldata resulted from related measurements derived from Chios meteorological station. Post-fire landslide inventorywas created after an extensive field survey of both areas before the beginning of the rainfall period (October 2016)and before the end of winter season (February 2017).Data classification of each factor according to their estimated LS followed, by using the reverse ranking method,where 1 is the least susceptible and 10 is the most one. Each category was normalized to 100% and the final rasterthematic maps of landslide controlling factors were produced. Finally, using numerical weight for each factor,which was assigned by the Analytic Hierarchy Process using Pairwise Comparison Method and according to theweighted linear combination, a map was generated where each cell has a certain post-fire LS index (LSI) value.The higher the LSI value, the higher the LS, whereas lower LSI value means lower LS.This procedure was repeated twice, first using pre-fire land cover and secondly using the severity of the fire events.The resulted maps, classified with natural breaks method, constitute the final pre- and post-fire LS maps of theaffected areas with five LS categories: very low, low, moderate, high and very high.Comparison of these two final maps showed, more or less, the same LS areas, but with LSI value enhanced. Thevalidated results showed good agreement between post-fire landslide occurrence and the produced post-fire LS maps.
Arabatzis T. Review of A. Franklin, What Makes a Good Experiment? Reasons and Roles in Science (Pittsburgh: University of Pittsburgh Press, 2016). Isis [Internet]. 2018;109(1):146-147. Publisher's Version
Diakakis M, Nikolopoulos E, Mavroulis S, Vassilakis E, Korakaki E. The role of wildfires in inducing hydrogeomorphological disasters in the Mediterranean. A case from Greece. EGU2018-7452. 2018;19.Abstract
Although forest fires are an integral part of Mediterranean forest ecosystems, they constitute one of the most devastating natural hazards in the region. Apart from the direct consequences, fires induce well-documented longer term effects in the geomorphological and hydrological processes, influencing environmental factors that in turn can affect the occurrence of other natural hazards, such as floods and mass movement phenomena.This work focuses on the forest fire of 2007 in Peloponnese, Greece that burnt 1773 km2, causing 78 fatalities and very significant damages in property and infrastructure and went down as the largest fire in the country’s record. It examines the occurrence of flood and mass movement phenomena, before and after this mega-fire and studies different influencing factors to investigate the degree to which the 2007 fire and/or other parameters have affected their frequency.Observational evidence based on several data sources collected during the period 1989-2016 show that the 2007 fire has contributed to an increase of average flood and mass movement events frequency by approximately 3.3 and 5.6 times respectively.Fire affected areas record a substantial increase in the occurrence of both phenomena, presenting a noticeably stronger increase compared to neighbouring areas that have not been affected. Examination of the monthly occurrence of events showed an increase even in months of the year were rainfall intensity presented decreasing trends.Although no major land use changes has been identified and chlorophyll is shown to recover 2 years after the fire incident, differences on the type of vegetation as tall forest has been substituted with lower vegetation are considered significant drivers for the observed changes in hydrogeomorphic response of the fire affected basins.The findings of this work are strong indications that future climatic change, with more frequent and severe droughts and storms will be a disastrous combination for the Mediterranean region.
Martzoukou O, Diallinas G, Amillis S. Secretory Vesicle Polar Sorting, Endosome Recycling and Cytoskeleton Organization Require the AP-1 Complex in . Genetics. 2018.Abstract
The AP-1 complex is essential for membrane protein traffic via its role in the pinching-off and sorting of secretory vesicles from the trans-Golgi and/or endosomes. While its essentiality is undisputed in metazoa, its role in simpler eukaryotes seems less clear. Here we dissect the role of AP-1 in the filamentous fungus and show that it is absolutely essential for growth due to its role in clathrin-dependent maintenance of polar traffic of specific membrane cargoes towards the apex of growing hyphae. We provide evidence that AP-1 is involved in both anterograde sorting of RabE-labeled secretory vesicles and RabA/B-dependent endosome recycling. Additionally, AP-1 is shown to be critical for microtubule and septin organization, further rationalizing its essentiality in cells that face the challenge of cytoskeleton-dependent polarized cargo traffic. This work also opens a novel issue on how non-polar cargoes, such as transporters, are sorted to the eukaryotic plasma membrane.
Mylonas MP, Barbouchi S, Herrmann H, Nastos PT. Sensitivity analysis of observational nudging methodology to reduce error in wind resource assessment (WRA) in the North Sea. Renewable Energy [Internet]. 2018;120:446-456. Website
Kostaki E-G, Karamitros T, Bobkova M, Oikonomopoulou M, Magiorkinis G, Garcia F, Hatzakis A, Paraskevis D. Spatiotemporal characteristics of the HIV-1 CRF02_AG/CRF63_02A1 epidemic in Russia and central Asia. AIDS Res Hum Retroviruses. 2018.Abstract
BACKGROUND: Eastern European countries including Russia, Ukraine and other former Soviet Union (FSU) countries have experienced an HIV epidemic spreading mostly among people who inject drugs (PWID). We aimed to investigate the origin and the dispersal patterns of HIV-1 CRF02_AG in Russia and other FSU countries. METHODS: We studied 136 CRF02_AG sequences originating from Russia, and FSU countries along with a globally sampled dataset of 3,580 CRF02_AG sequences. Maximum-likelihood phylogeny reconstruction with bootstrap evaluation was conducted in RAxML. Bayesian phylogeographic analysis was performed in BEAST v1.8 using the discrete trait model. RESULTS: We found that all CRF02_AG sequences from Russia and other FSU countries formed a single monophyletic cluster within CRF02_AG radiation. The Russian/FSU clade was classified as CRF63_02A1. Sequences from the FSU countries clustered further within distinct subclades (two from Russia, three from Uzbekistan and one Kazakhstan) according to the geographic origin of sampling. Molecular clock analysis revealed that the tMRCA of the CRF63_02A1 epidemic was in 1996 (95%HPD: 1992-1999), while for the two Russian subclades, tMRCA was estimated in 2003 (95%HPD: 2001-2004) and in 2007 (95%HPD: 2005-2008). Phylogeographic analysis suggested that the potential origin of the epidemic was in Uzbekistan. Early dispersal of CRF63_02A1 occurred in Kazakhstan and Uzbekistan and thereafter the epidemic spread to Russia. Notably, spillover transmissions to Russia kept occurring in both countries. DISCUSSION: Previous studies have shown that Russia and Ukraine have provided the source for the PWID-driven, HIV-1 subtype-A epidemic, spreading across the FSU countries (AFSU). In great contrast, CRF63_02A1 established an epidemic in central Asia (Uzbekistan and Kazakhstan), from where it subsequently disseminated to Russia. Our study suggests that cross-border transmissions among PWID occur bi-directionally between Russian and other FSU populations. These results are of public health importance and suggest that prevention actions have to be reinforced in this area to assist the management of high-risk practices.
Vagenas G. Statistical Applications in Sport Science With Examples in SPSS (Στατιστικές Εφαρμογές στην Αθλητική Επιστήμη με Παραδείγματα στο SPSS). 6th ed. THESSALONIKI: TZIOLA PUBLICATIONS (ISBN: 978-960-418-747-8); 2018 pp. 490.
Rizou D, Flocas HA, Hatzaki M, Bartzokas A. A Statistical Investigation of the Impact of the Indian Monsoon on the Eastern Mediterranean Circulation. Atmosphere [Internet]. 2018;9(3). Publisher's VersionAbstract
The Indian summer monsoon (ISM) is a prominent feature of the summer circulation in the Northern Hemisphere (NH) and has been found to modulate the weather and climate conditions in many remote regions. This study investigates the most recurrent patterns of summertime midlatitude circulation, over the eastern Mediterranean (EM) and also globally, that are most associated with the ISM. Monthly data of 44 summers from the ERA40 dataset are used and two multidimensional statistical methods, the Principal Component Analysis (PCA) and Canonical Correlation Analysis (CCA), are implemented. The ISM is found to be related to subsidence anomalies in the middle and more extendedly in the upper troposphere over the central and eastern Mediterranean and with an Etesian-like pattern regarding the field of the lower troposphere winds. An equatorial Rossby wave pattern, extending westward from an ISM heat source up to EM and N. Africa, was identified to be associated with the variability of ISM. The observed relationship between the ISM and the EM circulation features can be attributed to this equatorial Rossby wave response to the monsoon forcing. CCA implementation revealed the interconnection of the aforementioned PCA results with an ISM action center over the northern Arabian Sea and the monsoon trough region.
Pyle E, Kalli AC, Amillis S, Hall Z, Lau AM, Hanyaloglu AC, Diallinas G, Byrne B, Politis A. Structural Lipids Enable the Formation of Functional Oligomers of the Eukaryotic Purine Symporter UapA. Cell Chem Biol. 2018.Abstract
The role of membrane lipids in modulating eukaryotic transporter assembly and function remains unclear. We investigated the effect of membrane lipids in the structure and transport activity of the purine transporter UapA from Aspergillus nidulans. We found that UapA exists mainly as a dimer and that two lipid molecules bind per UapA dimer. We identified three phospholipid classes that co-purified with UapA: phosphatidylcholine, phosphatidylethanolamine (PE), and phosphatidylinositol (PI). UapA delipidation caused dissociation of the dimer into monomers. Subsequent addition of PI or PE rescued the UapA dimer and allowed recovery of bound lipids, suggesting a central role of these lipids in stabilizing the dimer. Molecular dynamics simulations predicted a lipid binding site near the UapA dimer interface. Mutational analyses established that lipid binding at this site is essential for formation of functional UapA dimers. We propose that structural lipids have a central role in the formation of functional, dimeric UapA.
Olson A, Bannert N, Sönnerborg A, de Mendoza C, Price M, Zangerle R, Chaix M-L, Prins M, Kran A-MB, Gill J, et al. Temporal trends of transmitted HIV drug resistance in a multinational seroconversion cohort. AIDS. 2018;32(2):161-169.Abstract
BACKGROUND: The rate of transmitted drug resistance (TDR) may increase with wider use of antiretroviral therapy and can contribute to therapeutic failure. We analysed time trends in TDR among HIV seroconverters. METHODS: Using CASCADE data of individuals with well estimated dates of HIV seroconversion, we examined HIV nucleotide sequences collected prior to antiretroviral therapy use from 1996-2012. All samples were taken within 12 months of testing HIV positive. Using logistic regression, we examined the association between TDR and year of seroconversion, adjusting for confounders. RESULTS: Of 4717 individuals seroconverting between 1996 and 2012, median (IQR) age at seroconversion was 33 (27, 39) years. The majority (3839; 92%) were male, mainly exposed through MSM (3767; 80%), and infected with subtype B (3464; 73%). Overall, 515 (11%) individuals had at least one drug resistance-related mutation; 280 individuals with nucleoside reverse transcriptase, 185 with nonnucleoside reverse transcriptase, and 144 with protease inhibitor mutations. Estimated TDR prevalence was 19.4% (8.2, 36.0) in 1996, significantly decreasing to 8.5% (5.9, 11.9) in 2012 [odds ratio (OR; 95% confidence interval (CI)) = 0.92 (0.90, 0.95) per year increase]. Individuals exposed through sex between men and women were significantly less likely to have been infected with a drug-resistant strain [OR (95% CI) = 0.59 (0.41, 0.87) compared with MSM], and there was marginal evidence that sampling during acute infection was associated with higher odds of resistance [OR (95% CI) = 1.20 (0.97, 1.7), P = 0.093] compared with later sampling. CONCLUSION: TDR has decreased over calendar time although a significant proportion of new infections still carry resistance-related mutations.
Samitas A, Asteriou D, Polyzos S, Kenourgios D. Terrorist incidents and tourism demand: Evidence from Greece. Tourism Management Perspectives [Internet]. 2018;25:23-28. Publisher's VersionAbstract
The purpose of this paper is to examine the impact of terrorism on tourism demand in Greece using monthly data from 1977 to 2012. We investigate whether this relationship is bidirectional and whether it exhibits long run persistence. Thus, we employ a large dataset of terrorist incidents and perform cointegration and long-run causality tests, correcting our data for cyclical seasonality and applying PCA to construct a terrorism proxy according to the severity of the incident. Our findings concur that terrorism has a significant negative impact on tourist arrivals to Greece and that causality is noted from terrorism to tourism only. The results suggest that authorities should establish firm measures against terrorism and that further actions should be taken to promote tourism, safety and security, as a response to terrorist incidents. Our study is, to the best our knowledge, the first to approach terrorism using a three-factor proxy with qualitative features.
Vagenas G, Palaiothodorou D, Knudson D. Thirty-year trends of study design and statistics in applied sports and exercise biomechanics research. International Journal of Exercise Science [Internet]. 2018;11(1):239-259. Publisher's VersionAbstract
This study documented the change in study design and statistics employed in applied sports and exercise biomechanics research from 1985 to 2014. The sample comprised 676 data based original research reports published in the Journal of Applied Biomechanics (JAB) from 1985 to 2014. Eight design and 10 statistical criteria were extracted from each study. Descriptive statistics were calculated and change in study criteria over time were documented. Design criteria that did not change over time, remaining at relatively low levels of rigor, were widespread (71%) use of small (2-20) sample sizes and examination of numerous dependent variables (26.6% with >13). The number of experimental groups and independent variables also did not change with typically 1 to 2 reported. There was a significant 61% linear increase in randomization of participants into groups, however by 2014 still a minority (39%) of studies were not reporting randomized assignment. Types of statistical analysis showed positive changes over time with a 48% quadratic decrease in descriptive analyses, a 3% linear increase in nonparametric statistics, and a 45% linear increase in reporting parametric statistical analysis. Changes in specific statistical methods included a 9% linear decrease in bivariate correlation and a 73% linear increase in ANOVA. Reporting of assumptions had a 35% linear increase, yet in 2014 sixty-five percent still did not report on meeting statistical assumptions. Changes in test statistics included a linear 56% increase of reporting observed P values and a quadratic 29% increase in reporting effect sizes beginning in the late 1990s. It was concluded there was evidence of small improvements in research design and statistics in JAB over the last 30 years; however, there is still room for improvement to meet higher levels of research rigor and current recommendations on statistical analysis and reporting.
vagenas_palaiothodorou_knudson_2018.pdf
Sagonas K, Valakos ED, Lymberakis P, Pafilis P. Traits of reproduction and feeding of the European Green Lizard, Lacerta viridis (LAURENTI, 1768), at the southern edge of its distribution. HERPETOZOA. 2018;30(3-4):115-129.
Mazis I. Turkey, Israel, Greece: Reshuffling in the Eastern Mediterranean. Civitas Gentium. 2018;6(1):13-80.Abstract
Lots have happened in the East-Mediterranean since the beginning of the third millennium. A list of the main events reveals a long series of issues that took place in the region and heavily affect it.  The impact of these issues and events will stay with us for the foreseeable future and is heavily discernible in the relations between the eastern- Mediterranean non- Arab littoral countries: Turkey, Israel, Greece and Cyprus. This list includes, for example, the 2000s deteriorating relations between Turkey and Israel (in 2016 the two resumed full diplomatic relations); the current crises in the relations between Turkey several Middle Eastern countries (Egypt, Syria, Iraq); the civil war that rages in Syria since 2011 and Turkey’s deep involvement in it; acts of Islamist led terrorism, attacks by ISIS1, and manifestations of religious extremism that heavily affect daily life, economies and tourism in Turkey, Egypt, Jordan, Iraq, as well as in other places; illegal immigrants, refugees and asylum seekers that inundate Turkey, Greece (and via them) many EU countries; energy explorations in the Mediterranean Sea; issues related to civil rights, minorities, the growing tendencies towards strong executives and authoritarian regimes at the expense of democracy and pluralism; heavy internal changes like the decline of Turkish Kemalism, the growing impact of religion in Israel and Turkey, and the fi nancial crisis of Greece; In addition, the struggle for self-determination of various ethnic groups and peoples (the Kurds, the Palestinians, and others); the Russian reappearance, American disappearance and the EU weak impact on events in the Middle East and the Eastern – Mediterranean - - these and subjects have brought about dramatic changes in the Eastern Mediterranean sub-system. 1. See at the end of this text: ANNEX: Evidence on the Collaboration of Turkey with ISIS and other jihadist groups, as well as relevant testimonies from international sources. From the Turkish standpoint, the events in our region express what is happening in the global arena: Europe is aging, its economy and currency are limping and convulsing, and the EU radiates political disintegration (the Brexit) and economic weaknesses. The US is suffering from an economic crisis, it is globally and politically on the decline, internally it is also on the decline following the eight years’ presidency of Barak Obama, and the November 2016 election of President Donald Trump. Simultaneously, other powers (China, Russia) strive to replace American hegemony all around the globe. Also from the standpoint of Ankara, Turkey desires to be now a rising «uneasy» power, and is demarcating the limits of its infl uence: Central Asia, the Caucasus and the Balkans, on the one hand; black Africa, North Africa, and the Middle East, on the other. Following several setbacks, Turkish- Russian relations are developing and disagreements have been settled. And all these developments and events have greatly affected the three eastern - Mediterranean non - Muslim countries (Greece, Israel, Cyprus), and the region’s sole non- Arab but Muslim country- Turkey. In our paper we will make an attempt to describe and analyze the major impacts that these events and issues have had on the developments in the eastern- Mediterranean, with particular focus on Turkey and Israel, and the growing cooperation between Greece and Israel.
1._mazis.pdf
Bella S, Moser A. What's in a first?The link between impromptu invitations and their responses. Journal of Pragmatics [Internet]. 2018;125:96-110. Publisher's VersionAbstract
This paper examines Greek invitations as first pair parts of an adjacency pair within the framework of Conversation Analysis. The focus of our research is on impromptu invitations issued via polar negative-interrogative constructions and the effects this type of construction has on the interactional organization of the whole invitation-response sequence. It is suggested that the issuing of the invitation by means of this particular syntactic choice has ramifications for the unfolding of the interaction with respect to sequencing and preference organization. Specifically, it is maintained that impromptu invitations issued by means of polar negative-interrogatives in Greek tend to trigger markedly delayed acceptances. It is suggested that the explanation for this phenomenon lies in the “cross-cutting” preferences built in the construction when used to make impromptu invitations.
Giovani C, Kamberidou I, Patsantaras N. ΕΠΑΝΕΞΕΤΑΖΟΝΤΑΣ ΤΗΝ ΚΟΙΝΩΝΙΚΗ ΣΗΜΑΣΙΑ ΤΗΣ ΦΥΣΙΚΗΣ ΑΓΩΓΗΣ ΚΑΙ ΤΗ ΘΕΣΗ ΤΗΣ ΣΤΟ ΣΗΜΕΡΙΝΟ ΣΧΟΛΕΙΟ. In: «Η κοινωνιολογία και ο δημόσιος ρόλος της στην εποχή της μεταμόρφωσης του κόσμου»: 6ο ΣΥΝΕΔΡΙΟ ΤΗΣ ΕΛΛΗΝΙΚΗΣ ΚΟΙΝΩΝΙΟΛΟΓΙΚΗΣ ΕΤΑΙΡΕΙΑΣ (ΕΚΕ) - HELLENIC SOCIOLOGICAL SOCIETY (HSS), March 28-31, 2018 Athens, Greece. Athens Greece. Συνεδρία: ΚΟΙΝΩΝΙΟΛΟΓΙΑ ΤΗΣ ΕΚΠΑΙΔΕΥΣΗΣ: ΕΛΛΗΝΙΚΗ ΚΟΙΝΩΝΙΟΛΟΓΙΚΗ ΕΤΑΙΡΕΙΑ (EKE); 2018.Abstract
Η Φυσική αγωγή (ΦΑ), ως μάθημα στην Πρωτοβάθμια και Δευτεροβάθμια Εκπαίδευση χαρακτηρίζεται από την ιδιαιτερότητά της , καθώς περιλαμβάνει την οργανωμένη και συστηματική κινητική δραστηριότητα των μαθητών/μαθητριών μέσα από βιωματικές και διαθεματικές προσεγγίσεις. Όπως επισημαίνεται από ένα σημαντικό αριθμό  ερευνητικών δεδομένων μέσα από το  παιχνίδι και τις αθλοπαιδιές καλλιεργούνται κοινωνικές δεξιότητες και σημαντικές κοινωνικές αξίες— όπως η δικαιοσύνη, το ομαδικό πνεύμα, η αλληλεγγύη, ο σεβασμός προς τον αντίπαλο και τους κανόνες—  που είναι απαραίτητες για μια ποιοτική κοινωνική συνύπαρξη. Η παρούσα μελέτη αποτελεί μέρος μιας εν εξελίξει ποιοτικής  έρευνας και εδράζεται σε μια ενδελεχή ανασκόπηση της σχετικής με αυτό το ζήτημα βιβλιογραφίας στο πλαίσιο της οποίας διαπιστώνεται, αφ’ ενός η σημαντικότητα της ΦΑ για την προετοιμασία σωματικά, ψυχικά και κοινωνικά ενεργών πολιτών και αφ’ ετέρου διαπιστώνεται ότι οι υλικοτεχνικές υποδομές και  ο χρόνος που διατίθεται στο σχολικό πρόγραμμα για το μάθημα της ΦΑ λειτουργούν αναντίστοιχα για την πραγμάτωση των πολύπλευρων  σκοπών που καλείται αυτή να εκπληρώσει. Συμπερασματικά και με βάση τα μέχρι τώρα ερευνητικά δεδομένα, προτείνεται η αναδιαμόρφωση του σχολικού προγράμματος σχετικά με το μάθημα της ΦΑ προκειμένου να μπορούν να εφαρμοστούν επιπλέον καινοτόμα προγράμματα και να επιτευχθεί ο απώτερος σκοπός της δια βίου άσκησης.                        
eke_conference_draft_program.pdf eke_conf_2018_programme_book.pdf
Kamberidou I. Ψηφιακές Δεξιότητες και Ψηφιακό Χάσμα. Εισήγηση στην ημερίδα του WOMEN IN TECH, the fifty-fifty project ”, 20/4/2018 Orange Grove, Embassy of the Netherlands in Athens. 2018. women_in_tech_agenda.png digital_skills_presentation_sample._irene_kamberidou.pdf dsc_0015_-_irene.jpg dsc_0128.jpg
2017
Kokotou MG, Galiatsatou G, Magrioti V, Koutoulogenis G, Barbayianni E, Limnios D, Mouchlis VD, Satpathy B, Navratil A, Dennis EA, et al. 2-Oxoesters: A Novel Class of Potent and Selective Inhibitors of Cytosolic Group IVA Phospholipase A2. Scientific Reports. 2017;7:7025.Abstract
Cytosolic phospholipase A2 (GIVA cPLA2) is the only PLA2 that exhibits a marked preference for hydrolysis of arachidonic acid containing phospholipid substrates releasing free arachidonic acid and lysophospholipids and giving rise to the generation of diverse lipid mediators involved in inflammatory conditions. Thus, the development of potent and selective GIVA cPLA2 inhibitors is of great importance. We have developed a novel class of such inhibitors based on the 2-oxoester functionality. This functionality in combination with a long aliphatic chain or a chain carrying an appropriate aromatic system, such as the biphenyl system, and a free carboxyl group leads to highly potent and selective GIVA cPLA2 inhibitors (XI(50) values 0.00007–0.00008) and docking studies aid in understanding this selectivity. A methyl 2-oxoester, with a short chain carrying a naphthalene ring, was found to preferentially inhibit the other major intracellular PLA2, the calcium-independent PLA2. In RAW264.7 macrophages, treatment with the most potent 2-oxoester GIVA cPLA2 inhibitor resulted in over 50% decrease in KLA-elicited prostaglandin D2 production. The novel, highly potent and selective GIVA cPLA2 inhibitors provide excellent tools for the study of the role of the enzyme and could contribute to the development of novel therapeutic agents for the treatment of inflammatory diseases.
Alevizaki A, Sainidou R, Rembert P, Morvan B, Stefanou N. Acoustic properties of double-porosity granular polymers. Physical Review B. 2017;95(21):214306 (10 pages).Abstract
Using an extension of the full elastodynamic layer-multiple-scattering method to structures of fluid-saturated poroelastic spherical bodies, a comprehensive theoretical study of the acoustic response of double-porosity submerged liquid-saturated granular polymeric materials of specific morphology consisting of touching porous polymer spheres arranged in a fcc lattice, beyond the long-wavelength effective-medium description, is presented. Calculated transmission and absorption spectra of finite slabs of these materials are analyzed by reference to the acoustic modes of the constituent porous spherical grains as well as to relevant dispersion diagrams of corresponding infinite crystals, and a consistent interpretation of the results is provided. In particular, it is shown that resonant modes with very long lifetime, localized in the spheres in the form of slow longitudinal waves, which are peculiar to poroelastic materials, are formed when the viscous length is much shorter than the radius of the inner pores of the spheres. These modes, which can be easily tuned in frequency by adjusting the intrinsic porosity of the spheres, induce some remarkable features in the acoustic behavior of these double-porosity materials, such as narrow dispersionless absorption bands and directional transmission gaps.
Aktionsart, aspect and category change in the history of Greek
Moser A. Aktionsart, aspect and category change in the history of Greek. In: K. Bentein, M. Janse & J. Soltic (eds.) Variation and Change in Ancient Greek Tense, Aspect and Modality. Leiden/Boston: Brill; 2017. pp. 131-157. Publisher's VersionAbstract
Aspect is more or less universally recognized as the defining TMA category of the Greek verbal system. There is a consensus on this in both the philological tradition and the linguistic literature on aspect. It is moreover almost universally accepted that diachronically the Greek verbal system has been extremely conservative, remaining practically unchanged down to the present day.This paper largely accepts the former assumption, but not the latter, which has been increasingly challenged in the last few years. It is argued here that, while there has been little change morphologically, the system has been altered in a fundamental way. More specifically, it takes up the analysis proposed in Moser (2008 and 2009), according to which the history of the Greek verb indicates that the system of three (and later two) stems shifts from the expression of Aktionsart (actionality/lexical aspect) to the expression of (grammatical) aspect, and develops it further, taking a fresh look at the data from a different point of view and in the light of recent studies.
Amphipolitics: archaeological performance and governmentality in Greece under the crisis. In: Greece in Crisis. The Cultural Politics of Austerity. London: I.B. Tauris; 2017. pp. 65-84.
Mazis I. Analyse geopolitique des Antagonismes Russo Americains en termes de politique energetique dans le sous-systeme des Balkans au sein du systeme Mediterraneen. Géographies, Géopolitiques et Géostratégies Régionales. 2017;V(1):25-35.Abstract
Au sein du complexe géopolitique méditerranéen, on observe ces derniers mois des mouvements dangereux de grande ampleur, dans le sous-système des Balkans occidentaux. La Grèce a le funeste privilège de constituer la frontière des deux sous-systèmes du complexe géopolitique méditerranéen:  a. du sous-système des Balkans et, b. du sous-système turco-proche-oriental. Nous allons démontrer d’une part, que ces deux sous-systèmes se trouvent confrontés à des disfonctionnements intenses et instables et d’autre part, que le facteur géopolitique déterminant de l’instabilité est celui de la sécurité énergétique. De surcroit, nous montrerons que les deux principaux pôles de puissances internationales que sont Moscou et Washington, de par leur antagonisme de type néo guerre froide, confèrent une dynamique déstabilisatrice au complexe géopolitique méditerranéen, dont l’épicentre se trouve dans les Balkans de l’ouest (Balkans occidentaux). La notion dite: «de type néo guerre froide» est utilisée pour souligner le fait qu’il existe une grande distance politico idéologique entre ces deux pôles (et bien sur, il en existe une plus grande encore entre Washington et Pékin), comme pendant la période de la guerre froide. La différence idéologique, en l’occurrence, réside entre l’approche cosmopolite et ultra libérale occidentale et l’approche nationale-identitaire conservatrice orientale, avec comme pole dominant Moscou.  Le corpus théorique de la présente analyse est celui de la géopolitique anglo-saxonne classique, issue de l’école de N. Spykman, ayant évolué avec l’approche de Z. Brzezinsky et celui de l’analyse géopolitique systémique contemporaine
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Matsangouras IT, Nastos PT, Bluestein HB, Pytharoulis I, Papachristopoulou K, Miglietta MM. Analysis of waterspout environmental conditions and of parent-storm behaviour based on satellite data over the southern Aegean Sea of Greece. International Journal of Climatology [Internet]. 2017;37:1022-1039. Website
Martzoukou O, Amillis S, Zervakou A, Christoforidis S, Diallinas G. The AP-2 complex has a specialized clathrin-independent role in apical endocytosis and polar growth in fungi. Elife. 2017;6.Abstract
Filamentous fungi provide excellent systems for investigating the role of the AP-2 complex in polar growth. Using Aspergillus nidulans, we show that AP-2 has a clathrin-independent essential role in polarity maintenance and growth. This is in line with a sequence analysis showing that the AP-2 β subunit (β2) of higher fungi lacks a clathrin-binding domain, and experiments showing that AP-2 does not co-localize with clathrin. We provide genetic and cellular evidence that AP-2 interacts with endocytic markers SlaB(End4) and SagA(End3) and the lipid flippases DnfA and DnfB in the sub-apical collar region of hyphae. The role of AP-2 in the maintenance of proper apical membrane lipid and cell wall composition is further supported by its functional interaction with BasA (sphingolipid biosynthesis) and StoA (apical sterol-rich membrane domains), and its essentiality in polar deposition of chitin. Our findings support that the AP-2 complex of dikarya has acquired, in the course of evolution, a specialized clathrin-independent function necessary for fungal polar growth.
Dahl V, Amnå E, Banaji S, Landberg M, Šerek J, Ribeiro N, Beilmann M, Pavlopoulos V, Zani B. Apathy or alienation? Political passivity among youths across eight European Union countries. European Journal of Developmental Psychology [Internet]. 2017:1-18. doi
Veloudis G, Pappas A, Gourgiotis S, Falidas E, Dimitriou N, Karavokiros I, Aggelou A, Komborozos V, Petraki C, Menounos P, et al. Assessing the clinical utility of Wnt pathway markers in colorectal cancer. J BUON. 2017;22(2):431-436.Abstract
PURPOSE: β-catenin and AXIN2 play an important role in the Wnt signaling pathway. The aim of this study was to investigate β-catenin and AXIN2 expression in colorectal cancer (CRC) and relate these findings with patients' clinicopathological features and prognosis. METHODS: 57 consecutive patients with surgically treated CRC were included in this study. Quantitative PCR and immunohistochemistry (IHC) analyses were performed to characterize the expression of the aforementioned markers in CRC tissues. RESULTS: β-catenin overexpression in the nucleus was associated with advanced N stage CRCs (p=0.04). Multivariate Cox regression analysis showed that β-catenin overexpression is an independent prognostic factor for overall survival (OS). A positive correlation between β-catenin location and AXIN2 mRNA was observed. CONCLUSIONS: Nuclear β-catenin is a valuable prognostic factor. AXIN2 is a component of the "Destruction Complex" and also a Wnt target gene. However, the clinical importance of AXIN2 expression in CRC remains unclear.
Kouroutzoglou J, Avgoustoglou E, Flocas HA, Hatzaki M, Skrimizeas P, Lalos A, Keay K, Simmonds I. Assessing the Sensitivity of COSMO/GR Atmospheric Model to Effectively Simulate the Influence of Diabatic Heating on Eastern Mediterranean Explosive Cyclogenesis Under Different Parameterizations of the Model Physics. In: Karacostas T, Bais A, Nastos PT Perspectives on Atmospheric Sciences. 1st ed. Springer International Publishing; 2017. pp. 9–15.
Nastos PT, Vassilakis E, Nastos M-PP, Charalampopoulos I, Matzarakis A. Assessment of continuous sky view factor based on ultra-high resolution natural colour images acquired by remotely piloted airborne systems for applications in an urban area of Athens. International Journal of Remote Sensing. 2017;38:5814-5829.Abstract
The thermal comfort conditions in a complex urban area is influenced by the surrounding structures and obstacles which modify the incoming radiation fluxes. A measure of this modification is the sky view factor (SVF), which could be estimated in each point of a selected area if a high resolution digital elevation model (DEM), or other urban morphological data including the manmade infrastructure, are available. The goal of this study is to model the continuous SVF for a complex building environment in the campus of National and Kapodistrian University of Athens, based on a high resolution DEM (0.09 m). For this purpose, we applied the structure-from-motion (SfM) technique, which takes advantage of the interpretation of ultra-high resolution colour images acquired by remotely piloted airborne systems, also known as drones or unmanned aerial vehicles. A quantitative analysis, by applying statistical metrics, yields perfect agreement between modelled and observed SVF values, over the examined area. The proposed methodology could be applied for human-biometeorology research in micro scale complex urban environments.
Nastos PT, Vassilakis E, Nastos M-PP, Charalampopoulos I, Matzarakis A. Assessment of continuous sky view factor based on ultra-high resolution natural colour images acquired by remotely piloted airborne systems for applications in an urban area of Athens. International Journal of Remote Sensing [Internet]. 2017;38:5814-5829. pdfAbstract
The thermal comfort conditions in a complex urban area is influenced by the surrounding structures and obstacles which modify the incoming radiation fluxes. A measure of this modification is the sky view factor (SVF), which could be estimated in each point of a selected area if a high resolution digital elevation model (DEM), or other urban morphological data including the manmade infrastructure, are available. The goal of this study is to model the continuous SVF for a complex building environment in the campus of National and Kapodistrian University of Athens, based on a high resolution DEM (0.09 m). For this purpose, we applied the structure-from-motion (SfM) technique, which takes advantage of the interpretation of ultra-high resolution colour images acquired by remotely piloted airborne systems, also known as drones or unmanned aerial vehicles. A quantitative analysis, by applying statistical metrics, yields perfect agreement between modelled and observed SVF values, over the examined area. The proposed methodology could be applied for human-biometeorology research in micro scale complex urban environments.
Caprara GV, Vecchione M, Schwartz SH, Schoen H, Bain PG, Silvester J, Cieciuch J, Pavlopoulos V, Bianchi G, Kirmanoglu H. Basic values, ideological self-placement, and voting: A cross-cultural study. Cross-Cultural Research [Internet]. 2017;51(4):388-411. Publisher's Version
Almpanis E, Pantazopoulos PA, Papanikolaou N, Yannopapas V, Stefanou N. A birefringent etalon enhances the Faraday rotation of thin magneto-optical films. Journal of Optics. 2017;19(7):075102 (8 pages).Abstract
The magneto-optical response of a Faraday-active Fabry–Pérot etalon with birefringent mirrors is studied by means of electrodynamic simulations using the finite-element and the scattering-matrix methods. The specific structure under consideration consists of a magnetic garnet film sandwiched between two metallic layers, patterned with periodically spaced parallel grooves on their outer sides. Our results are analyzed by reference to the properties of the individual structural components and a consistent interpretation of the different spectral features observed is provided. It is shown that, by properly adjusting the geometrical parameters involved, strong Faraday rotation enhancement can be obtained through constructive synergy between the Fabry–Pérot resonant mode of the magneto-optical nanocavity and the slot plasmon mode localized in the grooves.
Bakalis E, Mertzimekis TJ, Nomikou P, Zerbetto F. Breathing Modes of Kolumbo underwater volcano (Greece). Nature Sci. Rep. 2017.
Mazis I, Sgouros G. Cable and pipeline corridors under the legal framework of UNCLOS and the Energy Treaty. Geopolitical considerations at the Eastern Mediterranean Sea. Regional Science Inquiry. 2017;IX(1).Abstract
This article is divided in three sections; the first is presenting the plethora of fiber optic and power cable geographical distribution, providing to the reader an insight to underwater infrastructure. Readers can bind together the importance of survey, lay, repair and maintenance of underwater cables and pipelines, based on the legal framework provided by the Energy Treaty and UNCLOS. The second section provides a brief report on notions mentioned in the International Energy Treaty. We also mention the Energy Treaty and the Energy Treaty Charter as a case study for pipeline and power cable installations; At the third section, we focus especially at the genesis of UNCLOS with regards to the EEZ maritime zone regime; At this section, we will present the difference between the terms marine research and cable route study, based on the applicable UNCLOS conventional terminology. The last section of this article will be an effort to carefully examine whether these two Treaties are sufficient to regulate transnational cable surveying and laying operations under the current geopolitical frame in the Eastern Mediterranean Sea; as new oil and gas fields are being developed in the region two factors affect the geopolitical equilibrium: 1) The disputed EEZ's in the Eastern Mediterranean, 2) The role of Turkey based on its destabilizing and revisionist stand as this is highlighted by extreme geopolitical behaviors causing the present instability in the geopolitical environment of the Eastern Mediterranean, mainly with regards to the supply of energy from discovered gas reservoirs in the Eastern Mediterranean.
rsi_june_2017_ix_1.pdf
Papaioannou TG, Vavuranakis M, Tousoulis D. Calibration of noninvasive central blood pressure devices and negative aortic-to-brachial systolic pressure amplification. Kidney International [Internet]. 2017;91(1):253 - 254. Website
Chng W-J, Goldschmidt H, Dimopoulos MA, Moreau P, Joshua D, Palumbo A, Facon T, Ludwig H, Pour L, Niesvizky R, et al. Carfilzomib–dexamethasone vs bortezomib–dexamethasone in relapsed or refractory multiple myeloma by cytogenetic risk in the phase 3 study ENDEAVOR. Leukemia [Internet]. 2017. WebsiteAbstract
The randomized phase 3 study ENDEAVOR demonstrated a statistically significant and clinically meaningful improvement in progression-free survival (PFS) for carfilzomib and dexamethasone (Kd) vs bortezomib and dexamethasone (Vd) in relapsed or refractory multiple myeloma (MM). We conducted a preplanned subgroup analysis of ENDEAVOR to evaluate Kd vs Vd by cytogenetic risk. Of 785 patients with known cytogenetics, 210 (27%) had high-risk cytogenetics (Kd, n=97 (25%); Vd, n=113 (28%)) and 575 (73%) had standard-risk cytogenetics (Kd, n=284 (75%); Vd, n=291 (72%)). Median PFS in the high-risk group was 8.8 months for Kd vs 6.0 months for Vd (hazard ratio (HR), 0.65; 95% confidence interval (CI), 0.45–0.92; P=0.0075). Median PFS in the standard-risk group was not estimable for Kd vs 10.2 months for Vd (HR, 0.44; 95% CI, 0.33–0.58; P<0.0001). Overall response rates were 72.2% (Kd) vs 58.4% (Vd) in the high-risk group and 79.2% (Kd) vs 66.0% (Vd) in the standard-risk group. In the high-risk group, 15.5% (Kd) vs 4.4% (Vd) achieved a complete response (CR) or better. In the standard-risk group, 13.0% (Kd) vs 7.9% (Vd) achieved ⩾CR. This preplanned subgroup analysis found that Kd was superior to Vd in relapsed or refractory MM, regardless of cytogenetic risk.Leukemia advance online publication, 3 February 2017; doi:10.1038/leu.2016.390. © 2017 The Author(s)
Chng W-J, Goldschmidt H, Dimopoulos MA, Moreau P, Joshua D, Palumbo A, Facon T, Ludwig H, Pour L, Niesvizky R, et al. Carfilzomib–dexamethasone vs bortezomib–dexamethasone in relapsed or refractory multiple myeloma by cytogenetic risk in the phase 3 study ENDEAVOR. Leukemia [Internet]. 2017. WebsiteAbstract
The randomized phase 3 study ENDEAVOR demonstrated a statistically significant and clinically meaningful improvement in progression-free survival (PFS) for carfilzomib and dexamethasone (Kd) vs bortezomib and dexamethasone (Vd) in relapsed or refractory multiple myeloma (MM). We conducted a preplanned subgroup analysis of ENDEAVOR to evaluate Kd vs Vd by cytogenetic risk. Of 785 patients with known cytogenetics, 210 (27%) had high-risk cytogenetics (Kd, n=97 (25%); Vd, n=113 (28%)) and 575 (73%) had standard-risk cytogenetics (Kd, n=284 (75%); Vd, n=291 (72%)). Median PFS in the high-risk group was 8.8 months for Kd vs 6.0 months for Vd (hazard ratio (HR), 0.65; 95% confidence interval (CI), 0.45–0.92; P=0.0075). Median PFS in the standard-risk group was not estimable for Kd vs 10.2 months for Vd (HR, 0.44; 95% CI, 0.33–0.58; P<0.0001). Overall response rates were 72.2% (Kd) vs 58.4% (Vd) in the high-risk group and 79.2% (Kd) vs 66.0% (Vd) in the standard-risk group. In the high-risk group, 15.5% (Kd) vs 4.4% (Vd) achieved a complete response (CR) or better. In the standard-risk group, 13.0% (Kd) vs 7.9% (Vd) achieved ⩾CR. This preplanned subgroup analysis found that Kd was superior to Vd in relapsed or refractory MM, regardless of cytogenetic risk.Leukemia advance online publication, 3 February 2017; doi:10.1038/leu.2016.390. © 2017 The Author(s)
Mitsi E. "The Caryatid and the Collector: British Travel Writing and the Material Past in Early Nineteenth-Century Athens". Travelling around Cultures: Collected Essays on Literature and Art. 2017:228-44.
Caryatids lost and regained: rebranding the classical body in contemporary Greece. Journal of Greek Media & Culture [Internet]. 2017;3(1):3-29. Publisher's VersionAbstract
This article examines patterns of reception through which a particular type of classical sculpture – the Caryatid – has been accepted into the cultural life of contemporary Greece. Loved by neoclassical architecture, though also prominent in Modern Greek design, as well as contemporary poetry and drama, the Caryatid serves as a logo for the country and the Greeks at large, especially when referring to their relations with their fellow-Europeans. In contemporary Greek culture, Caryatids are deployed as symbols of Greekness as well as a means to achieve the nation’s cultural emancipation against the supremacy of western, globalised modernity. Often derided as mere symptoms of colonial mimicry, through their inherent qualities of parody and subversiveness, such uses may sometimes prove unexpectedly successful in undermining modernity and its templates.
Krys K, Capaldi CA, Tilburg W, Lipp OV, Bond MH, Vauclair C, Manickam SLS, Domínguez‐Espinosa A, Torres C, Lun VM‐C. Catching up with wonderful women: The women‐are‐wonderful effect is smaller in more gender egalitarian societies. International Journal of Psychology [Internet]. 2017. doi
Melagraki G, Ntougkos E, Rinotas V, Papaneophytou C, Leonis G, Mavromoustakos T, Kontopidis G, Douni E, Afantitis A, Kollias G. Cheminformatics-aided discovery of small-molecule Protein-Protein Interaction (PPI) dual inhibitors of Tumor Necrosis Factor (TNF) and Receptor Activator of NF-κB Ligand (RANKL). PLoS Computational Biology [Internet]. 2017;13(4). Website
Grigori K, Loukas YL, Malenović A, Samara V, Kalaskani A, Dimovasili E, Kalovidouri M, Dotsikas Y. Chemometrically assisted development and validation of LC–MS/MS method for the analysis of potential genotoxic impurities in meropenem active pharmaceutical ingredient. Journal of Pharmaceutical and Biomedical Analysis [Internet]. 2017;145:307-314. Website
Banaji S, Mejias S, Kouts R, Piedade F, Pavlopoulos V, Tzankova I, Mackova A, Amnå E. Citizenship’s tangled web: Associations, gaps and tensions in formulations of European youth active citizenship across disciplines. European Journal of Developmental Psychology [Internet]. 2017:1-20. doi
Schulpis KH, Thodi G, Iakovou K, Chatzidaki M, Dotsikas Y, Molou E, Triantafylli O, Loukas YL. Clinical evaluation and mutational analysis of GALK and GALE genes in patients with galactosemia in Greece: One novel mutation and two rare cases. Journal of Pediatric Endocrinology and Metabolism [Internet]. 2017;30:775-779. Website
Ntountaniotis D, Vanioti Μ, Kordopati GG, Kellici TF, Marousis KD, Mavromoustakos T, Spyroulias GA, Golic Grdadolnik S, Tselios TV. A combined NMR and molecular dynamics simulation study to determine the conformational properties of rat/mouse 35-55 myelin oligodendrocyte glycoprotein epitope implicated in the induction of experimental autoimmune encephalomyelitis. Journal of Biomolecular Structure and Dynamics [Internet]. 2017;35(7):1559 - 1567. Website
de Vries RP, Riley R, Wiebenga A, Aguilar-Osorio G, Amillis S, Uchima CA, Anderluh G, Asadollahi M, Askin M, Barry K, et al. Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus. Genome Biol. 2017;18(1):28.Abstract
BACKGROUND: The fungal genus Aspergillus is of critical importance to humankind. Species include those with industrial applications, important pathogens of humans, animals and crops, a source of potent carcinogenic contaminants of food, and an important genetic model. The genome sequences of eight aspergilli have already been explored to investigate aspects of fungal biology, raising questions about evolution and specialization within this genus. RESULTS: We have generated genome sequences for ten novel, highly diverse Aspergillus species and compared these in detail to sister and more distant genera. Comparative studies of key aspects of fungal biology, including primary and secondary metabolism, stress response, biomass degradation, and signal transduction, revealed both conservation and diversity among the species. Observed genomic differences were validated with experimental studies. This revealed several highlights, such as the potential for sex in asexual species, organic acid production genes being a key feature of black aspergilli, alternative approaches for degrading plant biomass, and indications for the genetic basis of stress response. A genome-wide phylogenetic analysis demonstrated in detail the relationship of the newly genome sequenced species with other aspergilli. CONCLUSIONS: Many aspects of biological differences between fungal species cannot be explained by current knowledge obtained from genome sequences. The comparative genomics and experimental study, presented here, allows for the first time a genus-wide view of the biological diversity of the aspergilli and in many, but not all, cases linked genome differences to phenotype. Insights gained could be exploited for biotechnological and medical applications of fungi.
Vlachou M, Papamichael M, Siamidi A, Fragouli I, Afroudakis PA, Kompogennitaki R, Dotsikas Y. Comparative in vitro controlled release studies on the chronobiotic hormone melatonin from cyclodextrins-containing matrices and cyclodextrin: Melatonin complexes. International Journal of Molecular Sciences [Internet]. 2017;18. Website
Karvelis H, Kouroutzoglou J, Flocas HA, Hatzaki M, Tsiourta K, Lalos A, Keay K, Simmonds I. Comparison of the synoptic environment and mechanisms of two cases of surface cyclogenesis in Greek area associated to strong low-level cold surges. In: Karacostas T, Bais A, Nastos PT Perspectives on Atmospheric Sciences. 1st ed. Springer International Publishing; 2017. pp. 397–402.
Chatzigeorgiou P, Mourelatou A, Pollatos E, Margari D, Zogzas N, Viras K, Mavromoustakos T, Semidalas CE. Comparison of the thermal behavior and conformational changes in partially and fully hydrated dipalmitoylphosphatidylcholine systems. Journal of Thermal Analysis and Calorimetry [Internet]. 2017:1 - 12. Website
Raptopoulos G, Kyriakou K, Mali G, Scarpellini A, Anyfantis G, Mavromoustakos T, Pitsikalis M, Paraskevopoulou P. Copolymerization of Norbornene and Norbornadiene Using a cis-Selective Bimetallic W-Based Catalytic System. Polymers [Internet]. 2017;9:141. Publisher's Version
Raptopoulos G, Kyriakou K, Mali G, Scarpellini A, Anyfantis GC, Mavromoustakos T, Pitsikalis M, Paraskevopoulou P. Copolymerization of Norbornene and Norbornadiene Using a cis-Selective Bimetallic W-Based Catalytic System. Polymers. 2017;9(4):141.
Raptopoulos G, Kyriakou K, Mali G, Scarpellini A, Anyfantis GC, Mavromoustakos T, Pitsikalis M, Paraskevopoulou P. Copolymerization of norbornene and norbornadiene using a cis-selective bimetallic W-based catalytic system. Polymers [Internet]. 2017;9(4). Website
Mazzoni D, Albanesi C, Ferreira PD, Opermann S, Pavlopoulos V, Cicognani E. Cross-border mobility, European identity and participation among European adolescents and young adults. European Journal of Developmental Psychology [Internet]. 2017:1-16. doi
Sioupouli G, Lambrinidis G, Mikros E, Amillis S, Diallinas G. Cryptic purine transporters in Aspergillus nidulans reveal the role of specific residues in the evolution of specificity in the NCS1 family. Mol Microbiol. 2017;103(2):319-332.Abstract
NCS1 proteins are H(+) or Na(+) symporters responsible for the uptake of purines, pyrimidines or related metabolites in bacteria, fungi and some plants. Fungal NCS1 are classified into two evolutionary and structurally distinct subfamilies, known as Fur- and Fcy-like transporters. These subfamilies have expanded and functionally diversified by gene duplications. The Fur subfamily of the model fungus Aspergillus nidulans includes both major and cryptic transporters specific for uracil, 5-fluorouracil, allantoin or/and uric acid. Here we functionally analyse all four A. nidulans Fcy transporters (FcyA, FcyC, FcyD and FcyE) with previously unknown function. Our analysis shows that FcyD is moderate-affinity, low-capacity, highly specific adenine transporter, whereas FcyE contributes to 8-azaguanine uptake. Mutational analysis of FcyD, supported by homology modelling and substrate docking, shows that two variably conserved residues (Leu356 and Ser359) in transmembrane segment 8 (TMS8) are critical for transport kinetics and specificity differences among Fcy transporters, while two conserved residues (Phe167 and Ser171) in TMS3 are also important for function. Importantly, mutation S359N converts FcyD to a promiscuous nucleobase transporter capable of recognizing adenine, xanthine and several nucleobase analogues. Our results reveal the importance of specific residues in the functional evolution of NCS1 transporters.
Kellici TF, Mavromoustakos T, Jendrossek D, Papageorgiou AC. Crystal structure analysis, covalent docking, and molecular dynamics calculations reveal a conformational switch in PhaZ7 PHB depolymerase. Proteins: Structure, Function and Bioinformatics [Internet]. 2017;85(7):1351 - 1361. Website
Gavriatopoulou M, Terpos E, Kastritis E, Dimopoulos MA. Current treatment options and investigational drugs for Waldenstrom’s Macroglobulinemia. Expert Opinion on Investigational Drugs [Internet]. 2017;26(2):197 - 205. WebsiteAbstract
Introduction: Waldenström’s Macroglobulinemia (WM) is a rare, indolent, incurable, low-grade B-cell lymphoplasmacytic neoplasm. This review article provides a modern clinical perspective of the individualized management of patients with symptomatic WM, in the context of the updated treatment guidelines and the currently available trial data. Areas covered: Rituximab-based regimens (such as the dexamethasone, rituximab and cyclophosphamide combination, DRC) are the most widely used in the management of both newly diagnosed and relapsed/refractory patients with WM. Recently, the Bruton’s tyrosine kinase inhibitor ibrutinib has been licensed for use in WM with exciting results. Several investigational single agent and combination regimens are being evaluated for response, efficacy and tolerability in phase II clinical trials, including new generation monoclonal antibodies (ofatumumab), immunomodulatory agents (thalidomide and lenalidomide), proteasome inhibitors (bortezomib and carfilzomib), Bruton’s tyrosine kinase inhibitors (ibrutinib and acalabrutinib), phosphoinositide 3-kinase/protein kinase B (Akt)/mammalian target of rapamycin pathway inhibitors (everolimus and perifosene), and histone deacetylase inhibitors (panobinostat) both in the setting of newly diagnosed and relapsed/refractory disease. Expert opinion: WM therapeutic approach should be individualized for each patient in accordance to the intensity of the disease characteristics, age, comorbidities, efficacy, tolerability and safety profile of each drug. © 2017 Informa UK Limited, trading as Taylor & Francis Group.
Gavriatopoulou M, Terpos E, Kastritis E, Dimopoulos MA. Current treatment options and investigational drugs for Waldenstrom’s Macroglobulinemia. Expert Opinion on Investigational Drugs [Internet]. 2017;26(2):197 - 205. WebsiteAbstract
Introduction: Waldenström’s Macroglobulinemia (WM) is a rare, indolent, incurable, low-grade B-cell lymphoplasmacytic neoplasm. This review article provides a modern clinical perspective of the individualized management of patients with symptomatic WM, in the context of the updated treatment guidelines and the currently available trial data. Areas covered: Rituximab-based regimens (such as the dexamethasone, rituximab and cyclophosphamide combination, DRC) are the most widely used in the management of both newly diagnosed and relapsed/refractory patients with WM. Recently, the Bruton’s tyrosine kinase inhibitor ibrutinib has been licensed for use in WM with exciting results. Several investigational single agent and combination regimens are being evaluated for response, efficacy and tolerability in phase II clinical trials, including new generation monoclonal antibodies (ofatumumab), immunomodulatory agents (thalidomide and lenalidomide), proteasome inhibitors (bortezomib and carfilzomib), Bruton’s tyrosine kinase inhibitors (ibrutinib and acalabrutinib), phosphoinositide 3-kinase/protein kinase B (Akt)/mammalian target of rapamycin pathway inhibitors (everolimus and perifosene), and histone deacetylase inhibitors (panobinostat) both in the setting of newly diagnosed and relapsed/refractory disease. Expert opinion: WM therapeutic approach should be individualized for each patient in accordance to the intensity of the disease characteristics, age, comorbidities, efficacy, tolerability and safety profile of each drug. © 2017 Informa UK Limited, trading as Taylor & Francis Group.
Pikoulis E, Salem KM, Avgerinos ED, Pikouli A, Angelou A, Pikoulis A, Georgopoulos S, Karavokyros I. Damage Control for Vascular Trauma from the Prehospital to the Operating Room Setting. Front Surg. 2017;4:73.Abstract
Early management of vascular injury, starting at the field, is imperative for survival no less than any operative maneuver. Contemporary prehospital management of vascular trauma, including appropriate fluid and volume infusion, tourniquets, and hemostatic agents, has reversed the historically known limb hemorrhage as a leading cause of death. In this context, damage control (DC) surgery has evolved to DC resuscitation (DCR) as an overarching concept that draws together preoperative and operative interventions aiming at rapidly reducing bleeding from vascular disruption, optimizing oxygenation, and clinical outcomes. This review addresses contemporary DCR techniques from the prehospital to the surgical setting, focusing on civilian vascular injuries.
Kostaki E, Magiorkinis G, Psichogiou M, Flampouris A, Iliopoulos P, Papachristou E, Daikos GL, Bonovas S, Otelea D, Friedman SR, et al. Detailed Molecular Surveillance of the HIV-1 Outbreak Among People who Inject Drugs (PWID) in Athens During a Period of Four Years. Curr HIV Res. 2017;15(6):396-404.Abstract
BACKGROUND: New diagnoses of HIV-1 infection among people who inject drugs (PWID) increased significantly during 2011 in Athens. OBJECTIVE: Our aim was to investigate the patterns of HIV epidemic spread among PWID and to estimate the transmission dynamics for the major local transmission networks (LTNs). METHODS: We analyzed sequences from 2,274 HIV-infected subjects sampled in Greece during 01/01/2011-31/10/2014. Of specimens in our sample, 874 sequences were isolated from HIV-infected PWID. Phylodynamic analysis was performed using birth-death serial skyline models. RESULTS: Phylogenetic analysis revealed that the majority of sequences from PWID (N=746, 85.4%) fell within four LTNs: CRF14_BG (N=456, 58.3%), CRF35_AD (N=149, 19.1%), subtype B (N=118, 15.1%) and A1 (N=59, 7.5%). In addition to PWID, we also found that sequences from 36 non-PWID belonged to the LTNs corresponding to cross-group transmissions. Based on the estimated plots of the effective reproductive number (Re) over time, subtype A1 and CRF35_AD LTNs showed a sharp increase before and during 2011 (maximum value of Re=3.0 and Re=4.6, respectively). For subtype B and CRF14_BG LTNs, the Re was increasing until the end of 2012 (maximum value of Re=3.2 and Re=3.0, respectively). CONCLUSION: HIV transmissions within subtype A1 and CRF35_AD LTNs increased sharply during the early stage of the outbreak, in contrast to subtype B and CRF14_BG. A significant reduction in the number of infections was estimated on all transmission networks from the beginning of 2013 onwards. Prevention measures that took place in the Athens metropolitan area at the end of 2012 including also the ARISTOTLE program may explain this decrease.
Zerefos CS, Eleftheratos K, Kapsomenakis J, Solomos S, Inness A, Balis DS, Redondas A, Eskes H, Allaart M, Amiridis V, et al. Detecting volcanic sulfur dioxide plumes in the Northern Hemisphere using the Brewer spectrophotometers, other networks, and satellite observations. Atmospheric Chemistry and Physics [Internet]. 2017;17:551-574. Publisher's Version a30_acp_2017.pdf
Argyrou MD, Bassiakos Y, Tsipouri L. Determinants of the Profitability of Greek Enterprises before and after the Crisis. MIBES Transactions. 2017;10(2):122-139.Abstract
This research project investigates the influence of a number of economic and financial variables on the profitability of Greek enterprises from 2006 to 2013, namely: annual revenue, exports as a binary variable, number of employees, sectoral composition, investments and founding year. Three models were tested using linear stepwise regression as well as logistic regression. The fit to the data is low, indicating that other important factors, in addition to those tested, influence the development of corporate profits more. Running the models for individual years we see that in the years 2010 and 2011 mark a shift in the direction of the relation of several of our variables to profits (such as the age of the enterprise and the number of employees). The full application of austerity policies because of the crisis may be the explanation for that, indicating that the crisis did not have a unified influence on profitability. More importantly statistically significant results are observed in relations which conflict with economic theory, namely exports are negatively correlated to profitability (Model 1) or not correlated at all (Model 2). Our models do not contribute to understanding the determinants of profitability but rather the difficulties to identify smooth profitability patterns at times of crisis and austerity. The research is still in progress as we strive to improve the explanatory power of the models, by expanding the number of variables and using additional statistical methods.
Vrontaki E, Melagraki G, Voskou S, Phylactides MS, Mavromoustakos T, Kleanthous M, Afantitis A. Development of a predictive pharmacophore model and a 3D-QSAR study for an in Silico screening of new potent BCR-ABL kinase inhibit. Mini-Reviews in Medicinal Chemistry [Internet]. 2017;17(3):188 - 204. Website
Rodríguez-Pose A, Boschma R, Tsipouri L, Βonaccorsi, A. The Diffusion Deficit and Economic Convergence. In: Europe's Future: Open innovation, open science, open to the world, reflections of the RISE group. Luxembourg: European Commission, DG Research and Innovation; 2017. pp. 35-46.
Farangitakis G, Christopoulou A, Vassilakis Ε, Papanikolaou I, Arianoutsou Μ. Do landscape properties affect the process of post-fire vegetation recovery? A case study from the Taygetos Mountain, Greece. In: XIV MEDECOS & XIII AEET meeting. Seville, Spain; 2017. pp. 114. posterAbstract
Fires of 2007 have consumed large areas of Black pine and endemic fir forests in Greece. The current research aims at examining the role of geomorphology and lithology that govern the soil properties upon the post-fire vegetation recovery at the landscape level. A case study from Taygetos Mt, a large part of which was burned in 2007, is presented. Based on the interpretation of a high spatial and spectral resolution satellite image (WorldView-3, 4/2015), GIS thematic layers have been created showing unburned and regenerated patches over various lithological types. A network of sites was selected for field sampling representing various combinations of the above. Data on recovery of the main tree species as well as on total vegetation cover were collected. Results prove the relationship between regeneration ability and plant species traits as well as the existence of unburned patches near the burned ones. Black pine had regenerated from seeds dispersed from cones that have remained intact on unburned or scorched trees, close enough to the burned patches, while Greek fir presented remarkably low regeneration, lacking of any response mechanism. Plant species recovery seems to be controlled by the geology as it was found weaker in plots overlying carbonate, permeable, not easily erodible formations as compared to that observed over clastic, impermeable, erodible formations of schists, even for the same species. In conclusion, post-fire vegetation recovery at the landscape level seems to be a complex process controlled not only from species biology but also from the landscape features.
Misiakos EP, Bagias G, Papadopoulos I, Danias N, Patapis P, Machairas N, Karatzas T, Arkadopoulos N, Toutouzas K, Alexakis N, et al. Early Diagnosis and Surgical Treatment for Necrotizing Fasciitis: A Multicenter Study. Frontiers in Surgery [Internet]. 2017;4:5. WebsiteAbstract
Background: Necrotizing fasciitis (NF) is a group of relatively rare infections, usually caused by two or more pathogens. It affects the skin and subcutaneous tissues of lower and upper limbs, perineal area (Fournier’s gangrene) and the abdominal wall. Early diagnosis and aggressive surgical management are of high significance for the management of this potentially lethal disease. Methods: We conducted a retrospective study in patients who presented,during the last decade,at four University Surgical Departments in the area of Athens, Greece, with an admission diagnosis of NF. Demographic, clinical and laboratory data were gathered, and the preoperative and surgical treatment, as well as the postoperative treatment was analyzed for these patients. Results: A total of 62 patients were included in the study. The mean age of patients was 63.7 (47 male patients). Advanced age (over 65 years) (P<0.01) and female sex (P=0.04) correlated significantly with mortality. Perineum was the mostly infected site (46.8%), followed by the lower limbs (35.5%), and the upper limbs and the axillary region (8.1%). Diabetes mellitus was the most common co-existing disease (40.3%), followed by hypertension (25.8%) and obesity (17,7%). The most common symptom was local pain and tenderness (90.3%). Septic shock occurred in 8 patients (12.9%), and strongly correlated with mortality (P<0.01). Laboratory data were used to calculate retrospectively the LRINEC score of every patient; 26 patients (41.9%) had LRINEC score under 6, 20 patients (32.3%) had LRINEC score 6-8 and 16 patients (25.8%) had LRINEC score >9. Surgical debridement was performed in all patients (mean no. of repeated debridement 4.8), and in 16 cases (25.8%) the infected limb was amputated. The mean length of hospital stay was 19.7 days, and the overall mortality rate of our series was 17.7%. Conclusions: Diagnosis of NF requires high suspect among clinicians, as its clinical image is non-specific. Laboratory tests can depict the severity of the disease; therefore they must be carefully evaluated. Urgent surgical debridement is the mainstay of treatment in all patients; the need of repetitive surgical debridement is undisputed.
Moris D, Karavokyros I, Spartalis E, Athanasiou A, Schizas D, Felekouras E. Early prediction of systematic inflammatory response syndrome (SIRS) after major thoracic operation should not be sneezed at, but it is not a panacea. Surgery. 2017;161(5):1462-1463.
Moris D, Schizas D, Karaolanis G, Karavokyros I. eComment: Neutrophil-to-lymphocyte ratio: Ambitious but Ambiguous marker. Interact Cardiovasc Thorac Surg. 2017;24(4):559.
Diakakis M, Nikolopoulos EI, Mavroulis S, Vassilakis E, Korakaki E. The effect of large forest fires on floods and landslides. The case of the 2007 fires in Ileia, Greece. Safe Athens 2017. 2017.Abstract
Although forest fires are considered an integral part of Mediterranean forest ecosystems, they nevertheless constitute one of the most devastating natural hazards. Apart from the direct consequences, fires induce longer term effects in the geomorphological and hydrological processes, influencing environmental factors that in turn can affect the occurrence of other natural hazards, such as floods and mass movement phenomena. This work focuses on the forest fire of 2007 in Peloponnese, Greece that burnt 1773 km2, causing 78 fatalities and very significant damages in property and infrastructure and went down as the largest fire in the country’s record. It examines the occurrence of flood and mass movement phenomena, before and after this mega-fire and studies different influencing factors to investigate the degree to which the 2007 fire and/or other parameters have affected their frequency.Observational evidence based on several data sources collected during the period 1989-2016 show that the 2007 fire has contributed to an increase of average flood and mass movement events frequency by approximately 3.3 and 5.6 times respectively. Fire affected areas record a substantial increase in the occurrence of both phenomena, presenting a noticeably stronger increase compared to neighbouring areas that have not been affected. Examination of the monthly occurrence of events showed an increase even in months of the year were rainfall intensity presented decreasing trends. Although no major land use changes has been identified and chlorophyll is shown to recover 2 years after the fire incident, differences on the type of vegetation as tall forest has been substituted with lower vegetation are considered significant drivers for the observed changes in hydrogeomorphic response of the fire affected basins.
Stefi AL, Margaritis LH, Christodoulakis NS. The effect of the non ionizing radiation on exposed, laboratory cultivated upland cotton (Gossypium hirsutum L.) plants. Flora: Morphology, Distribution, Functional Ecology of Plants [Internet]. 2017;226:55 - 64. WebsiteAbstract
A series of experiments was carried out to investigate possible structural or biochemical alterations in Gossypium hirsutum plants after a long term (21 days) exposure to non ionizing radiation (1882 MHz) emitted from the base unit of a cordless DECT system. Exposed plants, compared to the negative (matched) controls, seem to be seriously affected. Notably lower biomass production for the above ground part and the root was recorded. Reduction of the photosynthetic pigments and severe damage of the chloroplast structure were also observed. It seems that non ionizing radiation can be noxious for plant life functions. © 2016 Elsevier GmbH
Foufopoulos J, Roca V, White KA, Pafilis P, Valakos ED. Effects of island characteristics on parasitism in a Mediterranean lizard (Podarcis erhardii): A role of population size and island history?. North-Western Journal of Zoology [Internet]. 2017;13(1):70 - 76. Website
Diakakis M, Nikolopoulos E, Mavroulis S, Emm. V, Korakaki E. The effects of the 2007 Peloponnese forest fires in rainfall-triggered, flood and mass movement phenomena. A 10-years lasting impact. In: 11th Intern. Hydrogeological Conference. Athens; 2017.Abstract
Apart from direct consequences, forest fires induce water related effects related to geomorphological and hydrological processes, triggering floods and mass movement phenomena. This work focuses on the forest fire of 2007 in Peloponnese, Greece that to date corresponds to the largest fire in the country’s record. It examines the occurrence of flood and mass movement phenomena, before and after this fire and analyses different influencing factors to investigate the degree to which the 2007 fire and/or other parameters have affected their frequency. Observational evidence collected during the period 1989-2016 show that the 2007 fire has contributed to an increase of average flood and mass movement events frequency by approximately 3.3 and 5.6 times respectively. Fire affected areas record a substantial increase in the occurrence of both phenomena, presenting a noticeably stronger increase compared to neighbouring areas that have not been affected. Examination of the monthly occurrence of events showed an increase even in months of the year were rainfall intensity presented decreasing trends. Although no major land use changes has been identified and chlorophyll is shown to recover 2 years after the fire incident, differences on the type of vegetation as tall forest has been substituted with lower vegetation are considered significant drivers for the observed increase in flood and mass movement frequency in the fire affected areas.
Chatoupis C, Vagenas G. Effects of two practice style formats on fifth grade students motor skill performance and task engagement. The Physical Educator [Internet]. 2017;74(2):220-238. Publisher's VersionAbstract
We investigated the effectiveness of two teaching formats that fall under the canopy of Mosston and Ashworth’s (2008) practice style, on fifth grade students’ motor skill performance and task engagement. Both formats are also known as station teaching or learning centers. In the teacher-rotated format (TR), the teacher decides the amount of time apportioned during practice at each station, whereas in the learner-rotated format (LR), each learner decides on task order and the amount of time spent at each station. Ten-year-old children (N = 60) were randomly assigned to the TR group (n = 20), the LR group (n = 25), and a control group (n = 15). A soccer dribbling test was employed to evaluate the soccer dribbling skill prior to and after the instructional intervention. The same soccer dribbling tasks were taught to the learners in both treatment groups in eight 30-min sessions. ANCOVA on the posttest scores showed a significant difference between the experimental groups and the control group (p < .001) and between the two experimental groups, favoring the LR group (p < .001). A 3 × 2 (Group × Test) repeated measures ANOVA showed a significant improvement of the soccer dribbling skill for both teaching formats (p < .001) but not for the control group. An ANOVA on the overall practice trial data yielded significant differences between the two formats, favoring the LR group (p < .001). Both formats were found to be effective, but the results indicate that given the opportunity to reapportion their practice time, learners in the LR format took advantage of this opportunity and improved their performance further.
chatoupis_vagenas_2017_phys.educ_.pdf
Gavriatopoulou M, Terpos E, Kastritis E, Dimopoulos MA. Efficacy and safety of elotuzumab for the treatment of multiple myeloma. Expert Opinion on Drug Safety [Internet]. 2017;16(2):237 - 245. WebsiteAbstract
Introduction: Multiple myeloma (MM) is the second most common hematologic malignancy and despite significant outcome improvements with novel agents, the majority of patients will eventually relapse and develop treatment resistance. Immunotherapy is emerging as a promising therapeutic approach in MM. Areas covered: Elotuzumab is a monoclonal antibody directly targeting the SLAMF7 receptor, expressed on normal and malignant plasma cells. Elotuzumab has no meaningful antimyeloma activity when given as monotherapy to patients with relapsed or refractory MM (RRMM). However, it demonstrated significant antimyeloma activity in preclinical studies and when it is combined with other antimyeloma agents (i.e. bortezomib or lenalidomide) in clinical trials, it improved response and clinical outcomes with no additive toxicity. This review provides a brief description of the elotuzumab mechanism of action and an overview on its efficacy in preclinical and clinical trials, including its safety and toxicity profile. Expert commentary: Based on the results of a phase 3 clinical trial (ELOQUENT-2), which compared lenalidomide and dexamethasone with or without elotuzumab in patients with RRMM, elotuzumab was approved by FDA in November 2015 for MM patients who received 1–3 prior lines of therapy. Studies with combinations of elotuzumab with other anti-myeloma drugs in different phases of MM are ongoing. © 2017 Informa UK Limited, trading as Taylor & Francis Group.
Gavriatopoulou M, Terpos E, Kastritis E, Dimopoulos MA. Efficacy and safety of elotuzumab for the treatment of multiple myeloma. Expert Opinion on Drug Safety [Internet]. 2017;16(2):237 - 245. WebsiteAbstract
Introduction: Multiple myeloma (MM) is the second most common hematologic malignancy and despite significant outcome improvements with novel agents, the majority of patients will eventually relapse and develop treatment resistance. Immunotherapy is emerging as a promising therapeutic approach in MM. Areas covered: Elotuzumab is a monoclonal antibody directly targeting the SLAMF7 receptor, expressed on normal and malignant plasma cells. Elotuzumab has no meaningful antimyeloma activity when given as monotherapy to patients with relapsed or refractory MM (RRMM). However, it demonstrated significant antimyeloma activity in preclinical studies and when it is combined with other antimyeloma agents (i.e. bortezomib or lenalidomide) in clinical trials, it improved response and clinical outcomes with no additive toxicity. This review provides a brief description of the elotuzumab mechanism of action and an overview on its efficacy in preclinical and clinical trials, including its safety and toxicity profile. Expert commentary: Based on the results of a phase 3 clinical trial (ELOQUENT-2), which compared lenalidomide and dexamethasone with or without elotuzumab in patients with RRMM, elotuzumab was approved by FDA in November 2015 for MM patients who received 1–3 prior lines of therapy. Studies with combinations of elotuzumab with other anti-myeloma drugs in different phases of MM are ongoing. © 2017 Informa UK Limited, trading as Taylor & Francis Group.
Estudios y Homenajes Hispanoamericanos V. 1st ed. (Pavlakis EP, Symeonidis H, Pajovic S, Drosos DL, Chandler PM, Papageorgíou A, Kritikou V). Madrid: Ediciones del Orto; 2017 pp. 370. Publisher's Version
Estudios y Homenajes Hispanoamericanos V. 1st ed. (Pavlakis EP, Symeonidis H, Pajovic S, Drosos DL, Chandler PM, Papageorgíou A, Kritikou V). Madrid: Ediciones del Orto; 2017 pp. 370. Publisher's Version
Kritikou V. Santa de Federico Gamboa en su contexto histórico y social. In: Leopoldo Zea. Aproximación a la figura del filósofo mexicano. 1st ed. Madrid: Ediciones del Orto; 2017. pp. 91-102. santa-contexto_historico_social.pdf
Ἰσαῖος. Περὶ τοῦ Πύρρου κλήρου. Εἰσαγωγή, κείμενο, μετάφραση, ἑρμηνευτικὸ ὑπόμνημα. Αθήνα: Ακαδημία Αθηνών; 2017.
Oikonomakos P, Voukoutis L, Tsipouri L. Entrepreneurial quality: some evidence from Greek public policy. MIBES Transactions. 2017;11(1):73-91.Abstract
The present paper tries to devise a rating system for evaluating the likelihood of success of publicly supported companies. In recent literature we encounter quality indexes, composed of variables like name selection, registration location, intellectual property rights etc., which predict fairly accurately startup success. Unfortunately such indexes can only be compiled for countries with open administrations facilitating access and cross-checking of company data. We argue, however, that it is countries with less open administrations that have the highest need of ex ante quality assessment in order to maximise the public return of investment of state support mechanisms. This is why we suggest that, rather than giving up research on the likelihood of company growth because of lack of systematic open data, we can test firm dynamism based on public domain information. Dynamic firms, we assume, will be more likely to grow. The Web and Social Media data, which have until now mostly been used for marketing purposes, can be a valuable source of information for our purpose. We attempted to use the digital footprint as a proxy for the dynamism of SMEs and startups. Using State Aid schemes (i.e. public support to profit-oriented companies) in the period 2007-2013 in Greece we constructed a sample of 2000 companies and rated them individually for their presence (or not) in Facebook, LinkedIn, a site (with or without registered domain name), e-mail with domain name, references, size of the site, sales via web, search function, communication, regular update, FAQs and after sales support availability. Testing for sector, region, type of company and type of support scheme we find a statistically significant result for the more dynamic sectors, type of schemes and type of companies, while the regional level appears to be irrelevant, as companies in all regions demonstrate a fairly unified digital presence.
Pietri P, Papaioannou T, Stefanadis C. Environment: An old clue to the secret of longevity. Nature. 2017;544(7651):416.
Wagner B, Wilke T, Franke A, Albrecht C, Baumgarten H, Bertini A, Combourieu-Nebout N, Cvetkoska A, D'Addabbo M, Donders TH, et al. The environmental and evolutionary history of Lake Ohrid (FYROM/Albania): interim results from the SCOPSCO deep drilling project. Biogeosciencs [Internet]. 2017;14:2033-2054. Publisher's VersionAbstract
This study reviews and synthesises existing information generated within the SCOPSCO (Scientific Collaboration on Past Speciation Conditions in Lake Ohrid) deep drilling project. The four main aims of the project are to infer (i) the age and origin of Lake Ohrid (Former Yugoslav Republic of Macedonia/Republic of Albania), (ii) its regional seismotectonic history, (iii) volcanic activity and climate change in the central northern Mediterranean region, and (iv) the influence of major geological events on the evolution of its endemic species. The Ohrid basin formed by transtension during the Miocene, opened during the Pliocene and Pleistocene, and the lake established de novo in the still relatively narrow valley between 1.9 and 1.3 Ma. The lake history is recorded in a 584 m long sediment sequence, which was recovered within the framework of the International Continental Scientific Drilling Program (ICDP) from the central part (DEEP site) of the lake in spring 2013. To date, 54 tephra and cryptotephra horizons have been found in the upper 460 m of this sequence. Tephrochronology and tuning biogeochemical proxy data to orbital parameters revealed that the upper 247.8 m represent the last 637 kyr. The multi-proxy data set covering these 637 kyr indicates long-term variability. Some proxies show a change from generally cooler and wetter to drier and warmer glacial and interglacial periods around 300 ka. Short-term environmental change caused, for example, by tephra deposition or the climatic impact of millennial-scale Dansgaard–Oeschger and Heinrich events are superimposed on the long-term trends. Evolutionary studies on the extant fauna indicate that Lake Ohrid was not a refugial area for regional freshwater animals. This differs from the surrounding catchment, where the mountainous setting with relatively high water availability provided a refuge for temperate and montane trees during the relatively cold and dry glacial periods. Although Lake Ohrid experienced significant environmental change over the last 637 kyr, preliminary molecular data from extant microgastropod species do not indicate significant changes in diversification rate during this period. The reasons for this constant rate remain largely unknown, but a possible lack of environmentally induced extinction events in Lake Ohrid and/or the high resilience of the ecosystems may have played a role.
Ayouba A, Paraskevis D, Peeters M. Erratum to "Editorial for special issue on Evolution of HIV" [Infect. Genet. Evol., Vol. 46, December 2016, pp. 149]. Infect Genet Evol. 2017;48:164.
Sifnioti D, Soukissian T, Poulos S, Nastos P, Hatzaki M. Evaluation of in-situ wind speed and wave height measurements against reanalysis data for the Greek Seas. Mediterranean Marine Science [Internet]. 2017;13(3). Publisher's VersionAbstract
ERA-Interim, ECMWF’s reanalysis product, includes wave and atmospheric characteristics, with high temporal andspatial scale, providing more information on the marine state. Even though their assimilation process has been validated and verified in numerous studies, their performance in more local scales is still under examination. This research focuses on the evaluation of performance of ERA-Interim reanalysis datasets in the Greek Seas for wind and wave characteristics in comparison to POSEIDON buoy data. The results prove fair to good correlation for wave height (r = 0.67-0.94) and wind speed (r= 0.71-0.83) and different error statistics per sub-region. The upper 10% analysis shows an underestimate of 10-15% for wind speed and wave height from ERA-Interim in relation to the buoy measurements. The ERA-Interim and the buoy monthly means and standard deviations are also presented and discussed according to seasonal patterns. The results of the study are compared to other researches of wave hindcasting and wind reanalysis data for the Greek Seas and globally. It is shown that ERA-Interim products could be regarded as representative for the Greek Seas, although their application should be made with caution regarding the assessment of extreme conditions (i.e. given in analyses of upper percentiles) and especially at nearshore locations due to complex coastline configuration enhanced by the great number of islands
Sifnioti DE, Soukisian TS, Poulos SE, Nastos PT, Hatzaki M. Evaluation of in-situ wind speed and wave height measurements against reanalysis data for the Greek Seas. MEDITERRANEAN MARINE SCIENCE. 2017;18:486-503.Abstract
{ERA-Interim, ECMWF's reanalysis product, includes wave and atmospheric characteristics, with high temporal and spatial scale, providing more information on the marine state. Even though their assimilation process has been validated and verified in numerous studies, their performance in more local scales is still under examination. This research focuses on the evaluation of performance of ERA-Interim reanalysis datasets in the Greek Seas for wind and wave characteristics in comparison to POSEIDON buoy data. The results prove fair to good correlation for wave height (r=0.67-0.94) and wind speed (r=0.71-0.83) and different error statistics per sub-region. The analysis of the upper 10% (90th percentile) shows an underestimate of 10-15% for wind speed and wave height from ERA-Interim in relation to the buoy measurements. The ERA-Interim and the buoy monthly means and standard deviations are also presented and discussed according to seasonal patterns. The results of the study are compared to other researches of wave hindcasting and wind reanalysis data for the Greek Seas and globally. It is shown that ERA-Interim products could be regarded as representative for the Greek Seas, although their application should be made with caution regarding the assessment of extreme conditions (i.e. given in analyses of upper percentiles) and especially at nearshore locations due to complex coastline configuration enhanced by the great number of islands.}
Politi N, Nastos PT, Sfetsos A, Vlachogiannis D, Dalezios NR. Evaluation of the AWR-WRF model configuration at high resolution over the domain of Greece. Atmospheric Research [Internet]. 2017. Website
Nikolopoulos GK, Katsoulidou A, Kantzanou M, Rokka C, Tsiara C, Sypsa V, Paraskevis D, Psichogiou M, Friedman S, Hatzakis A. Evaluation of the limiting antigen avidity EIA (LAg) in people who inject drugs in Greece. Epidemiol Infect. 2017;145(2):401-412.Abstract
This analysis assessed the utility of the limiting antigen avidity assay (LAg). Samples of people who inject drugs (PWID) in Greece with documented duration of HIV-1 infection were tested by LAg. A LAg-normalized optical density (ODn) ⩽1·5 corresponds to a recency window period of 130 days. The proportion true recent (PTR) and proportion false recent (PFR) were estimated in 28 seroconverters and in 366 samples collected >6 months after HIV diagnosis, respectively. The association between LAg ODn and HIV RNA level was evaluated in 232 persons. The PTR was 85·7%. The PFR was 20·8% but fell to 5·9% in samples from treatment-naive individuals with long-standing infection (>1 year), and to 0 in samples with the circulating recombinant form CRF35 AD. A LAg-based algorithm with a PFR of 3·3% estimated a similar incidence trend to that calculated by analyses based on HIV-1 seroconversions. In recently infected persons indicated by LAg, the median log10 HIV RNA level was high (5·30, interquartile range 4·56-5·90). LAg can help identify highly infectious HIV(+) individuals as it accurately identifies recent infections and is correlated with the HIV RNA level. It can also produce reliable estimates of HIV-1 incidence.
Liossi AS, Ntountaniotis D, Kellici TF, Chatziathanasiadou MV, Megariotis G, Mania M, Becker-Baldus J, Kriechbaum M, Krajnc A, Christodoulou E, et al. Exploring the interactions of irbesartan and irbesartan–2-hydroxypropyl-β-cyclodextrin complex with model membranes. Biochimica et Biophysica Acta - Biomembranes [Internet]. 2017;1859(6):1089 - 1098. Website
Liapakis G, Matsoukas M-T, Karageorgos V, Venihaki M, Mavromoustakos T. Family B G protein-coupled receptors and their ligands: From structure to function. Current Medicinal Chemistry [Internet]. 2017;24(31):3323 - 3355. Website
From a "Garden of Disorder to a "Nest of Flames": Charles Henri Ford's Surrealist Inflections. Miranda: Revue pluridisciplinaire du monde anglophone [Internet]. 2017;14. Publisher's VersionAbstract
Virtually omitted from established narratives of American modernism, yet central in the histories of the reception of European Surrealism in the US, Charles Henri Ford’s life and work have been recovered in important queer genealogies within Anglo-American modernism. Yet within this process or recovery, Ford’s poetic work is still largely overlooked, and this may have to do less with its marked Surrealist influences and/or derivative aspects than with the somewhat unclassifiable and composite texture of Ford’s poems. This article revisits Ford’s early poetry as a space of convergence and dialogue between distinct yet interrelated poetics: from the 1938 A Garden of Disorder to the 1949, Sleep in a Nest of Flames, a queer subjectivity assimilates concurrently Surrealist poetics and Djuna Barnes’s equally unclassifiable queer modernism with and against American poetic modernisms.
Revithiadou A, Spyropoulos V, Markopoulos G. From fusion to agglutination: The case of Asia Minor Greek. Transactions of the Philological Society. 2017;115(3):297-335.Abstract
This article examines the nominal inflectional system of a group of Asia Minor Greek dialects (Dawkins 1910, 1916), which developed, in parallel with the fusional inflectional system, an agglutinative one due to language contact with Turkish. We argue that the ‘old’ fusional ending or the theme vowel was reanalyzed as part of the nominal stem. This novel structure was actualized by means of two competing options: in some dialects, the reanalysis was actualized transparently in all inflectional forms rendering an agglutinative pattern of inflection, whereas in dialects with limited agglutination the actualization took the form of a special type of vowel assimilation. More specifically, as part of the nominal stem, the ‘old’ theme vowel signals its merge with the root by allowing it to absorb some or all of its features. Formally, the phonological process is treated as an instance of indirect licensing (Walker 2011), according to which the theme vowel acts as a trigger due to its privileged position as a segment of the categorizer n, i.e. the head of the stem.
Kamberidou I. Gender, Volunteerism and Military Hospitals: War Nurses, Educators and Philanthropists of the Nineteenth-Century. The 14th ERGOMAS Conference: Military and Society: New Models for New Challenges, Working Group “Gender and the Military”. 2017:98-99.Abstract
Thousands of European and American women provided their services, lobbied, raised funds, food supplies and clothing to support the Greek Revolution.  Along with the relief activities of the 1820’s and 1830’s, the great interest in Greece produced a strong desire to send teachers and missionaries to Greece in Bondage.  Women’s 19th century accounts examine the position of the subjugated Greeks in the Aegean Islands and Asia Minor. European and American women—educators and philanthropists—worked for the advancement of female education. They even established schools for the preservation of Hellenic cultural heritage. This paper focuses on the first-hand accounts of 19th century European aristocratic and middle-class women volunteers, and specifically their social contribution during the Crimean War (1853-1856), when the English and French colonial experience encouraged female volunteerism. It spotlights the social service provided by English, French and German nurses and philanthropists—as agents of social change—who cared for the soldiers in the hospitals of Constantinople and its environs, concluding with their invaluable recommendations. The female accounts describe the British military and naval hospitals, hospital huts, nurses duties and difficulties confronted (1,500 patients per 3 volunteers); the Women’s Hospital; the French hospitals; the French military system; the Sisters of Mercy; the Sisters of Charity; the women who followed their husbands to war, including the destitute wives and babies of the English soldiers. Astonishing are the accounts concerning the degrading social status of the English soldier’s wife as opposed to the respect and protection enjoyed by the French soldier’s wife.  
letter_of_acceptance_gender_volunteerism_and_military_hospitals_war_nurses_educators.pdf ergomas_program_full_27_march_2017_ver.1_with_out_abstract.docx abstracts_pp._98-99._ergomas_program_full_17_may_2017._final_program.docx gender_volunteerism_and_military_hospitals.pdf
Gouliotis L, Foumelis M, Vassilakis E, Papanikolaou D, Pavlopoulos K. Geologic, Geomorphic and Geodetic Constraints on Vertical Motion Trends of Itea-Amfissa Basin (Northern Corinth Rift, Central Greece). In: EGU2017-6766. Vol. 19. Vienna, Austria; 2017.Abstract
Combining geological and geomorphological data together with geodetic SAR interferometry (InSAR) measurements an attempt has been made to investigate the vertical deformation of the Itea-Amfissa basin at the northern part of the Corinth rift. The north–south trending basin has been developed normally to the east – west trending Corinth Rift and on the hanging wall of the Itea-Amfissa detachment. In the stratigraphy of the Itea–Amfissa supra-detachment basin, two sequences can be distinguished; the lower marine polymict conglomerate of Early–Middle Miocene age and the upper terrestrial monomict carbonate breccia of Late Miocene age. The unconformity between them has been uplifted to the north of the basin up to the elevation of 1100m and subsided below sea level at its southern part. Remnants of low-relief surfaces are retained on top of the upper terrestrial sequence, that permit to reconstruct the paleo-landscape of the basin and to measure the spatial distribution of its vertical deformation after compensating the erosional isostatic adjustment. The exact delineation of the paleo-landscape, involved detailed mapping as well as quantitative analysis of geomorphological features caused by river incision, based on measurements of several tectonic geomorphology indices. Geodetic InSAR estimates of vertical ground displacements, combining almost 10 years of ascending and descending ENVISAT data, were also utilized both for refinement of delineated surfaces as well as for validation of geology-based deformation trends. Interferometric results were constrained to the geologic time frame, considering the well-defined long-term deformation trend of a doline, proven to be sinking over the last 6000 years. It is shown that over the last 10 years the largest uplift rates are observed within the Itea-Amfissa basin, while the coastline regions follow a more complex spatial deformation pattern of successive submergences and uplifts. The synthesis of geological and geomorphological data indicates that the Itea-Amfissa extensional basin from its development in the Middle-Late Miocene and throughout Plio-Quaternary, has been tilted towards south, while contemporary geodetic measurements from InSAR confirm that the basin is still uplifting with regard to its surrounding mountains and coastal areas.  
Mazis I. Geopolitical analysis of the Russo-American energy antagonism in the sub-system of the Balkans, in the greater system of the Mediterranean. Civitas Gentium [Internet]. 2017;5(4):27-34. Publisher's VersionAbstract
Greece has the ambiguous privilege of forming the intersection of two unstable Sub-systems of the Mediterranean Geopolitical Complex, i.e.: i. the Sub-system of the Balkans and ii. the Sub-system of Turkey and the Near East. We shall demonstrate that these two Sub-systems feature an intense joint function of instability in the present juncture and we shall also emphasize the main Geopolitical Factor that causes the aforementioned instability, i.e. energy security. Furthermore, we shall lay emphasis on the new Cold War-style antagonism between the two fundamental Poles of International Power, i.e. Moscow and Washington, an  antagonism  affecting  in  a  destabilizing  manner  the  Geopolitical  Complex  of  the  Mediterranean and in the Western Balkans regions as a main focal point. The term new Cold War-style is used so as to highlight the fact that there exists a considerable ideological distance between these two Poles (the same applies albeit in a different manner for the relations between Washington and Beijing), as was the case during the Cold War. The ideological difference in this case consists of the contrast between the neoliberal Western approach and the identitarian conservative approach of the East spearheaded by Moscow. Our analysis is based on the classic Anglo-Saxon geopolitical school and especially on N.J. Spykman’s «containment model», as the latter has been modified by Z. Brzesinsky. Our methodological approach is based on Systemic Geopolitical Analysis.
79-1-275-1-10-20171227.pdf
Mazis I. Geopolitics and contemporary international reality: knowledge, interpretation and prediction. Civitas Gentium [Internet]. 2017;5(4):21-26. Publisher's VersionAbstract
Knowledge of the geopolitical reality has been, is and shall be a challenge for political and spiritual leadership. The dominant actors in the globe are equipped with notable centers of research and study concerning the geopolitical reality. In this manner and taking into account the geopolitical models that derive from research they are able to plan their relative hegemonic or dominant international strategies. The current reality, though, is characterized by a tendency of revision concerning those traditional hermeneutic models of the Cold War period, a period during which known and ‘safe’ answers were provided for all social, political, economic and philosophical matters. These traditional ‘holistic’ models, which were applied on specifi c state actors and groups of state actors, were two: i) the socialist model and its dialectic opposite, ii) the liberal model. These two philosophical and ideological axes were complemented by the geopolitical model created by Nicholas J. Spykman (1893-1943), according to which there occurs a worldwide antagonism between Land Powers (Warsaw Pact, Soviet Union and satellite states) and Sea Powers (US, Great Britain, Japan, NATO and satellite states). This division led to the geopolitical, ideological, defensive, economic and therefore geostrategic alignment of the participating states into two clashing worlds, i.e. the Eastern and the Western world. This dominant division was adopted by the relevant elites of the various state actors that were part of the international structures of the International Power Poles. This phenomenon was prevalent throughout the 20th century and was manifested also in the relevant political cultures, dominant ideologies, as well as in the geostrategic approaches of the aforementioned International Power Poles and their respective satellites.
78-1-273-1-10-20171227.pdf
Mitsi E. “Greece ‘Digested in a Play’: Consuming Greek Heroism in The School of Abuse and Troilus and Cressida”. In: Shakespeare and Greece, ed. Alison Findlay and Vassiliki Markidou. Arden Bloomsbury; 2017. pp. 93-115.
Greece in Early English Travel Writing, 1586-1682
Mitsi E. Greece in Early English Travel Writing, 1586-1682. Palgrave Macmillan; 2017. Publisher's VersionAbstract
This book examines the letters, diaries, and published accounts of English and Scottish travelers to Greece in the seventeenth century, a time of growing interest in ancient texts and the Ottoman Empire. Through these early encounters, this book analyzes the travelers’ construction of Greece in the early modern Mediterranean world and shows how travel became a means of collecting and disseminating knowledge about ancient sites. Focusing on the mobility and exchange of people, artifacts, texts, and opinions between the two countries, it argues that the presence of Britons in Greece and of Greeks in England aroused interest not only in Hellenic antiquity, but also in Greece’s contemporary geopolitical role. Exploring myth, perception, and trope with clarity and precision, this book offers new insight into the connections between Greece, the Ottoman Empire, and the West.
Minnema MC, Kimby E, D’Sa S, Fornecker L-M, Poulain S, Snijders TJ, Kastritis E, Kremer S, Fitsiori A, Simon L, et al. Guideline for the diagnosis, treatment and response criteria for Bing-Neel syndrome. Haematologica [Internet]. 2017;102(1):43 - 51. WebsiteAbstract
Bing Neel syndrome is a rare disease manifestation of Waldenström’s macroglobulinemia that results from infiltration of the central nervous system by malignant lymphoplasmacytic cells. In this guideline we describe the clinical symptoms, as well as the appropriate laboratory and radiological studies, that can aid in the diagnosis. The presentation of Bing Neel syndrome may be very diverse, and includes headaches, cognitive deficits, paresis, and psychiatric symptoms. The syndrome can present in patients with known Waldenström’s macroglobulinemia, even in the absence of systemic progression, but also in previously undiagnosed patients. Diagnostic work-up should include cerebral spinal fluid analysis with multiparameter flow cytometry to establish B-cell clonality, protein electrophoresis and immunofixation for the detection and classification of a monoclonal protein as well as molecular diagnostic testing for immunoglobulin gene rearrangement and mutated MYD88. MRI of the brain and spinal cord is also essential. The second challenge is to expand our knowledge of prognosis and treatment outcome. Prospective clinical trials on Bing Neel syndrome patients that employ uniform treatment along with appropriate laboratory cerebral spinal fluid assessments and standardized MRI protocols will be invaluable, constituting a significant step forward in delineating treatment outcome for this intriguing disease manifestation. © 2017 Ferrata Storti Foundation.
Minnema MC, Kimby E, D’Sa S, Fornecker L-M, Poulain S, Snijders TJ, Kastritis E, Kremer S, Fitsiori A, Simon L, et al. Guideline for the diagnosis, treatment and response criteria for Bing-Neel syndrome. Haematologica [Internet]. 2017;102(1):43 - 51. WebsiteAbstract
Bing Neel syndrome is a rare disease manifestation of Waldenström’s macroglobulinemia that results from infiltration of the central nervous system by malignant lymphoplasmacytic cells. In this guideline we describe the clinical symptoms, as well as the appropriate laboratory and radiological studies, that can aid in the diagnosis. The presentation of Bing Neel syndrome may be very diverse, and includes headaches, cognitive deficits, paresis, and psychiatric symptoms. The syndrome can present in patients with known Waldenström’s macroglobulinemia, even in the absence of systemic progression, but also in previously undiagnosed patients. Diagnostic work-up should include cerebral spinal fluid analysis with multiparameter flow cytometry to establish B-cell clonality, protein electrophoresis and immunofixation for the detection and classification of a monoclonal protein as well as molecular diagnostic testing for immunoglobulin gene rearrangement and mutated MYD88. MRI of the brain and spinal cord is also essential. The second challenge is to expand our knowledge of prognosis and treatment outcome. Prospective clinical trials on Bing Neel syndrome patients that employ uniform treatment along with appropriate laboratory cerebral spinal fluid assessments and standardized MRI protocols will be invaluable, constituting a significant step forward in delineating treatment outcome for this intriguing disease manifestation. © 2017 Ferrata Storti Foundation.
Mari S, Volpato C, Papastamou S, Chryssochoou X, Prodromitis G, Pavlopoulos V. How political orientation and vulnerability shape representations of the economic crisis in Greece and Italy. International Review of Social Psychology [Internet]. 2017;30(1). doi
Nastos PT, Bleta AG, Matsangouras IT. Human thermal perception related to Föhn winds due to Saharan dust outbreaks in Crete Island, Greece. Theoretical and Applied Climatology [Internet]. 2017;128:635-647. Website
Panagopoulos P, Maltezos E, Hatzakis A, Paraskevis D. Hyperbilirubinemia in atazanavir treated HIV-infected patients: the impact of the UGT1A1*28 allele. Pharmgenomics Pers Med. 2017;10:205-208.Abstract
Combination antiretroviral treatment (cART) has significantly improved the life expectancy of people living with HIV. The life-long nature of cART increases the risk of side effects, which in some cases may have been caused by specific genetic characteristics. Patients treated with atazanavir (ATV) boosted with ritonavir (rit), which is a protease inhibitor used for the treatment of HIV, present with elevated bilirubin levels, at high proportions. ATV/rit-related hyperbilirubinemia has been previously associated with genetic characteristics in uridine diphosphate glucuronosyltransferase (UGT) enzyme. The prevalence of the UGT1A1*28 variant, which is the most frequent polymorphism in the UGT1A1 superfamily, has been found to range between 9% and ~60% with the highest frequency in Africa. Pharmacokinetics for additional HIV drugs, such as the integrase inhibitors Raltegravir and Elvitegravir, has been also shown to be influenced by UGT1A1 polymorphisms. Pharmacogenetics/pharmacogenomics testing can be useful to identify a patient's susceptibility to drug toxicity and therefore to facilitate selection of the optimal long-term suppressive regimen.
Dimopoulos MA, Trotman J, Tedeschi A, Matous JV, Macdonald D, Tam C, Tournilhac O, Ma S, Oriol A, Heffner LT, et al. Ibrutinib for patients with rituximab-refractory Waldenström's macroglobulinaemia (iNNOVATE): an open-label substudy of an international, multicentre, phase 3 trial. The Lancet Oncology [Internet]. 2017;18(2):241 - 250. WebsiteAbstract
Background In the era of widespread rituximab use for Waldenström's macroglobulinaemia, new treatment options for patients with rituximab-refractory disease are an important clinical need. Ibrutinib has induced durable responses in previously treated patients with Waldenström's macroglobulinaemia. We assessed the efficacy and safety of ibrutinib in a population with rituximab-refractory disease. Methods This multicentre, open-label substudy was done at 19 sites in seven countries in adults aged 18 years and older with confirmed Waldenström's macroglobulinaemia, refractory to rituximab and requiring treatment. Disease refractory to the last rituximab-containing therapy was defined as either relapse less than 12 months since last dose of rituximab or failure to achieve at least a minor response. Key exclusion criteria included: CNS involvement, a stroke or intracranial haemorrhage less than 12 months before enrolment, clinically significant cardiovascular disease, hepatitis B or hepatitis C viral infection, and a known bleeding disorder. Patients received oral ibrutinib 420 mg once daily until progression or unacceptable toxicity. The substudy was not prospectively powered for statistical comparisons, and as such, all the analyses are descriptive in nature. This study objectives were the proportion of patients with an overall response, progression-free survival, overall survival, haematological improvement measured by haemoglobin, time to next treatment, and patient-reported outcomes according to the Functional Assessment of Cancer Therapy-Anemia (FACT-An) and the Euro Qol 5 Dimension Questionnaire (EQ-5D-5L). All analyses were per protocol. The study is registered at ClinicalTrials.gov, number NCT02165397, and follow-up is ongoing but enrolment is complete. Findings Between Aug 18, 2014, and Feb 18, 2015, 31 patients were enrolled. Median age was 67 years (IQR 58–74); 13 (42%) of 31 patients had high-risk disease per the International Prognostic Scoring System Waldenström Macroglobulinaemia, median number of previous therapies was four (IQR 2–6), and all were rituximab-refractory. At a median follow-up of 18·1 months (IQR 17·5–18·9), the proportion of patients with an overall response was 28 [90%] of 31 (22 [71%] of patients had a major response), the estimated 18 month progression-free survival rate was 86% (95% CI 66–94), and the estimated 18 month overall survival rate was 97% (95% CI 79–100). Baseline median haemoglobin of 10·3 g/dL (IQR 9·3–11·7) increased to 11·4 g/dL (10·9–12·4) after 4 weeks of ibrutinib treatment and reached 12·7 g/dL (11·8–13·4) at week 49. A clinically meaningful improvement from baseline in FACT-An score, anaemia subscale score, and the EQ-5D-5L were reported at all post-baseline visits. Time to next treatment will be presented at a later date. Common grade 3 or worse adverse events included neutropenia in four patients (13%), hypertension in three patients (10%), and anaemia, thrombocytopenia, and diarrhoea in two patients each (6%). Serious adverse events occurred in ten patients (32%) and were most often infections. Five (16%) patients discontinued ibrutinib: three due to progression and two due to adverse events, while the remaining 26 [84%] of patients are continuing ibrutinib at the time of this report. Interpretation The sustained responses and median progression-free survival time, combined with a manageable toxicity profile observed with single-agent ibrutinib indicate that this chemotherapy-free approach is a potential new treatment choice for patients who had heavily pretreated, rituximab-refractory Waldenström's macroglobulinaemia. Funding Pharmacyclics LLC, an AbbVie Company. © 2017 Elsevier Ltd
Dimopoulos MA, Trotman J, Tedeschi A, Matous JV, Macdonald D, Tam C, Tournilhac O, Ma S, Oriol A, Heffner LT, et al. Ibrutinib for patients with rituximab-refractory Waldenström's macroglobulinaemia (iNNOVATE): an open-label substudy of an international, multicentre, phase 3 trial. The Lancet Oncology [Internet]. 2017;18(2):241 - 250. WebsiteAbstract
Background In the era of widespread rituximab use for Waldenström's macroglobulinaemia, new treatment options for patients with rituximab-refractory disease are an important clinical need. Ibrutinib has induced durable responses in previously treated patients with Waldenström's macroglobulinaemia. We assessed the efficacy and safety of ibrutinib in a population with rituximab-refractory disease. Methods This multicentre, open-label substudy was done at 19 sites in seven countries in adults aged 18 years and older with confirmed Waldenström's macroglobulinaemia, refractory to rituximab and requiring treatment. Disease refractory to the last rituximab-containing therapy was defined as either relapse less than 12 months since last dose of rituximab or failure to achieve at least a minor response. Key exclusion criteria included: CNS involvement, a stroke or intracranial haemorrhage less than 12 months before enrolment, clinically significant cardiovascular disease, hepatitis B or hepatitis C viral infection, and a known bleeding disorder. Patients received oral ibrutinib 420 mg once daily until progression or unacceptable toxicity. The substudy was not prospectively powered for statistical comparisons, and as such, all the analyses are descriptive in nature. This study objectives were the proportion of patients with an overall response, progression-free survival, overall survival, haematological improvement measured by haemoglobin, time to next treatment, and patient-reported outcomes according to the Functional Assessment of Cancer Therapy-Anemia (FACT-An) and the Euro Qol 5 Dimension Questionnaire (EQ-5D-5L). All analyses were per protocol. The study is registered at ClinicalTrials.gov, number NCT02165397, and follow-up is ongoing but enrolment is complete. Findings Between Aug 18, 2014, and Feb 18, 2015, 31 patients were enrolled. Median age was 67 years (IQR 58–74); 13 (42%) of 31 patients had high-risk disease per the International Prognostic Scoring System Waldenström Macroglobulinaemia, median number of previous therapies was four (IQR 2–6), and all were rituximab-refractory. At a median follow-up of 18·1 months (IQR 17·5–18·9), the proportion of patients with an overall response was 28 [90%] of 31 (22 [71%] of patients had a major response), the estimated 18 month progression-free survival rate was 86% (95% CI 66–94), and the estimated 18 month overall survival rate was 97% (95% CI 79–100). Baseline median haemoglobin of 10·3 g/dL (IQR 9·3–11·7) increased to 11·4 g/dL (10·9–12·4) after 4 weeks of ibrutinib treatment and reached 12·7 g/dL (11·8–13·4) at week 49. A clinically meaningful improvement from baseline in FACT-An score, anaemia subscale score, and the EQ-5D-5L were reported at all post-baseline visits. Time to next treatment will be presented at a later date. Common grade 3 or worse adverse events included neutropenia in four patients (13%), hypertension in three patients (10%), and anaemia, thrombocytopenia, and diarrhoea in two patients each (6%). Serious adverse events occurred in ten patients (32%) and were most often infections. Five (16%) patients discontinued ibrutinib: three due to progression and two due to adverse events, while the remaining 26 [84%] of patients are continuing ibrutinib at the time of this report. Interpretation The sustained responses and median progression-free survival time, combined with a manageable toxicity profile observed with single-agent ibrutinib indicate that this chemotherapy-free approach is a potential new treatment choice for patients who had heavily pretreated, rituximab-refractory Waldenström's macroglobulinaemia. Funding Pharmacyclics LLC, an AbbVie Company. © 2017 Elsevier Ltd
Vavuranakis M, Lavda M, Vrachatis D, Papaioannou TG, Kalogeras K, Kolokathis A-M, Kariori M, Lilly S, Siasos G, Oikonomou E, et al. Impact of balloon aortic valvuloplasty on transcatheter aortic valve implantation with self-expandable valve. Journal of Cardiology [Internet]. 2017;69(1):245 - 252. Website
Moreau P, Joshua D, Chng W-J, Palumbo A, Goldschmidt H, Hájek R, Facon T, Ludwig H, Pour L, Niesvizky R, et al. Impact of prior treatment on patients with relapsed multiple myeloma treated with carfilzomib and dexamethasone vs bortezomib and dexamethasone in the phase 3 ENDEAVOR study. Leukemia [Internet]. 2017;31(1):115 - 122. WebsiteAbstract
The randomized phase 3 ENDEAVOR study (N=929) compared carfilzomib and dexamethasone (Kd) with bortezomib and dexamethasone (Vd) in relapsed multiple myeloma (RMM). We performed a subgroup analysis from ENDEAVOR in patients categorized by number of prior lines of therapy or by prior treatment. Median progression-free survival (PFS) for patients with one prior line was 22.2 months for Kd vs 10.1 months for Vd, and median PFS for patients with ≥2 prior lines was 14.9 months for Kd vs 8.4 months for Vd. For patients with prior bortezomib exposure, the median PFS was 15.6 months for Kd vs 8.1 months for Vd, and for patients with prior lenalidomide exposure the median PFS was 12.9 months for Kd vs 7.3 months for Vd. Overall response rates (Kd vs Vd) were 81.9 vs 65.5% (one prior line), 72.0 vs 59.7% (≥2 prior lines), 71.2 vs 60.3% (prior bortezomib) and 70.1 vs 59.3% (prior lenalidomide). The safety profile in the prior lines subgroups was qualitatively similar to that in the broader ENDEAVOR population. In RMM, outcomes are improved when receiving treatment with carfilzomib compared with bortezomib, regardless of the number of prior therapy lines or prior exposure to bortezomib or lenalidomide. © 2017 Macmillan Publishers Limited, part of Springer Nature.
Moreau P, Joshua D, Chng W-J, Palumbo A, Goldschmidt H, Hájek R, Facon T, Ludwig H, Pour L, Niesvizky R, et al. Impact of prior treatment on patients with relapsed multiple myeloma treated with carfilzomib and dexamethasone vs bortezomib and dexamethasone in the phase 3 ENDEAVOR study. Leukemia [Internet]. 2017;31(1):115 - 122. WebsiteAbstract
The randomized phase 3 ENDEAVOR study (N=929) compared carfilzomib and dexamethasone (Kd) with bortezomib and dexamethasone (Vd) in relapsed multiple myeloma (RMM). We performed a subgroup analysis from ENDEAVOR in patients categorized by number of prior lines of therapy or by prior treatment. Median progression-free survival (PFS) for patients with one prior line was 22.2 months for Kd vs 10.1 months for Vd, and median PFS for patients with ≥2 prior lines was 14.9 months for Kd vs 8.4 months for Vd. For patients with prior bortezomib exposure, the median PFS was 15.6 months for Kd vs 8.1 months for Vd, and for patients with prior lenalidomide exposure the median PFS was 12.9 months for Kd vs 7.3 months for Vd. Overall response rates (Kd vs Vd) were 81.9 vs 65.5% (one prior line), 72.0 vs 59.7% (≥2 prior lines), 71.2 vs 60.3% (prior bortezomib) and 70.1 vs 59.3% (prior lenalidomide). The safety profile in the prior lines subgroups was qualitatively similar to that in the broader ENDEAVOR population. In RMM, outcomes are improved when receiving treatment with carfilzomib compared with bortezomib, regardless of the number of prior therapy lines or prior exposure to bortezomib or lenalidomide. © 2017 Macmillan Publishers Limited, part of Springer Nature.
Gierens K, Eleftheratos K. Improvements to the HIRS channel 12 intercalibration for ice supersaturation studies. GSICS Quarterly Newsletter: Spring Issue 2017 [Internet]. 2017;11(1):6-7. Publisher's Version v11_no1_2017.pdf
In Defense of Pharmaceutically Enhancing Human Morality
Protopapadakis ED. In Defense of Pharmaceutically Enhancing Human Morality. Current Therapeutic Research [Internet]. 2017;86:9-12. Publisher's VersionAbstract
Purpose I will discuss the prospect of pharmaceutically enhancing human morality and decision making in such a way as to eliminate morally unjustifiable choices and promote desirable ones. Background Our species in the relatively short period since it has emerged has enormously advanced in knowledge, science, and technical progress. When it comes to moral development, the distance it has covered is almost negligible. What if we could medically accelerate our moral development? What if we could once and for all render our species totally immune to certain vices? Methodology I will examine whether pharmaceutically intervening in human morality would compromise the autonomy of moral agents. I will argue that the argument from the autonomy of the moral agent is neither stable nor convincing. Conclusions In the light of Kantian ethics we might consider moral enhancement by pharmaceutical means to be a perfect duty for moral agents.
Vlachou M, Siamidi A, Diamantidi E, Iliopoulou A, Papanastasiou I, Ioannidou V, Kourbeli V, Foscolos A-S, Vocat A, Cole ST, et al. In vitro Controlled Release from Solid Pharmaceutical Formulations of two new Adamantane Aminoethers with Antitubercular Activity (I). Drug Research [Internet]. 2017;67(8):447 - 450. Website
Vlachou M, Siamidi A, Spaneas D, Lentzos D, Ladia P, Anastasiou K, Papanastasiou I, Foscolos A-S, Georgiadis M-O, Karalis V, et al. In vitro Controlled Release of two new Tuberculocidal Adamantane Aminoethers from Solid Pharmaceutical Formulations (II). Drug Research [Internet]. 2017. Website
Vrachatis DA, Papaioannou TG, Vavuranakis M, Tousoulis D. In Vivo Assessment of Atherosclerotic Plaque Neovascularization by Contrast-Enhanced Ultrasound: An Unsolved Mystery?. J Am Soc Echocardiogr. 2017.
Karavokyros I, Orfanos S, Angelou A, Meropouli A, Schizas D, Griniatsos J, Pikoulis E. Incidence and Risk Factors for Organ/Space Infection after Radiofrequency-Assisted Hepatectomy or Ablation of Liver Tumors in a Single Center: More than Meets the Eye. Front Surg. 2017;4:17.Abstract
INTRODUCTION: Surgical site infections (SSIs) and especially organ/space infection (O/SI) after resection or ablation of liver tumors are associated with increased morbidity and mortality. A secondary blood stream infection (BSI) is considered an O/SI but the exact prevalence is unknown. We aimed to investigate the incidence of O/SI and BSIs in a cohort of consecutive patients after liver resection or ablation, to seek for a possible connection between them and to search for potential risk factors. MATERIALS AND METHODS: We reviewed all patients who underwent hepatic resection or intraoperative liver ablation between January 2012 and December 2016 in our department. We focused on age, gender, Child-Pugh score, preoperative biliary drainage, indication for surgery, type of resection, resection or ablation of tumor, need for bilioenteric reconstruction, additional procedure to hepatectomy, blood transfusion, operative time, postoperative admission to ICU, and antibiotic chemoprophylaxis. All positive cultures from intra-abdominal fluids and blood were recorded. O/SI and BSIs were diagnosed by the criteria set by Centers for Disease Control. All variables were compared between the group with O/SI and the group without infection. BSIs were associated with these infections also. RESULTS: Eighty-one consecutive patients with a mean age of 64 years were enrolled. Fifteen patients presented a positive culture postoperatively: intra-abdominal fluid in eight, blood cultures in six, and both blood and intra-abdominal fluid in one patient. The directly estimated incidence of O/SI amounted to 11.1%. Four blood cultures were secondary to O/SI, and the remaining two secondary to central line catheter. O/SI was diagnosed indirectly, through the BSI in an additional 4.9% of the patients, raising the incidence of SSI to 16%. Among the factors studied, only admission to the ICU was found to be statistically significant as a risk factor for the development of O/SI ( = 0.026). CONCLUSION: O/SI should be actively seeked for after liver surgery including blood cultures. Patients with affected physical status, comorbidities are in greater risk of developing O/SI.
Kalisperati P, Spanou E, Pateras IS, Korkolopoulou P, Varvarigou A, Karavokyros I, Gorgoulis VG, Vlachoyiannopoulos PG, Sougioultzis S. Inflammation, DNA Damage, and Gastric Tumorigenesis. Front Genet. 2017;8:20.Abstract
is a Gram negative bacterium that colonizes the stomach of almost half human population. It has evolved to escape immune surveillance, establishes lifelong inflammation, predisposing to genomic instability and DNA damage, notably double strand breaks. The epithelial host cell responds by activation of DNA damage repair (DDR) machinery that seems to be compromised by the infection. It is therefore now accepted that genetic damage is a major mechanism operating in cases of induced carcinogenesis. Here, we review the data on the molecular pathways involved in DNA damage and DDR activation during infection.
Tsipouri, L. Innovation Policy in Southern Europe: smart specialisation versus path dependence. In: EU SMART SPECIALIZATION POLICY IN A COMPARATIVE PERSPECTIVE: THE EMERGING ISSUES. Elsevier; 2017.
Gierens K, Eleftheratos K. On the intercalibration of HIRS channel 12 brightness temperatures following the transition from HIRS 2 to HIRS 3/4 for ice saturation studies. Atmospheric Measurement Techniques [Internet]. 2017;10:681-693. Publisher's Version a31_amt_2017.pdf
Pavlopoulos V, Motti-Stefanidi F. Intercultural Relations in Greece. In: Mutual Intercultural Relations. Cambridge, UK: Cambridge University Press; 2017. pp. 187-209. pdf
Paraskevis D. Investigation of Human Immunodeficiency Virus Outbreaks Among People Who Inject Drugs: Timely Diagnosis and Molecular Surveillance are Crucial. J Infect Dis. 2017;216(9):1049-1050.
Mitsi E. "Killing the Humanist in Marlowe's The Massacre at Paris". War on the Human: New Responses to an Ever-Present Debate. 2017:174-190.
Karampela I, Kandri E, Antonakos G, Vogiatzakis E, Christodoulatos GS, Nikolaidou A, Dimopoulos G, Armaganidis A, Dalamaga M. Kinetics of circulating fetuin-A may predict mortality independently from adiponectin, high molecular weight adiponectin and prognostic factors in critically ill patients with sepsis: A prospective study. J Crit Care. 2017;41:78-85.Abstract
PURPOSE: Fetuin-A and adiponectin, major hepatokine and adipokine respectively, have been implicated in systematic inflammation. Our aim was to jointly investigate whether kinetics of circulating fetuin-A, adiponectin and its isoform HMWA predict 28-day mortality in sepsis. MATERIALS AND METHODS: In a prospective study, serum fetuin-A, adiponectin and HMWA were determined in 102 ICU patients fulfilling the diagnostic criteria of SEPSIS-3, at enrollment and one week after, and in 102 healthy controls matched on age and gender. RESULTS: Serum fetuin-A was significantly lower in septic patients than controls (p<0.001). Among septic patients, those with septic shock and nonsurvivors presented lower fetuin-A, but higher adiponectin and HMWA compared to patients with sepsis and survivors respectively, both at baseline and day 7 (p<0.001). Fetuin-A exhibited negative correlations with APACHE II, CRP, procalcitonin, adiponectin and IL-6 but a positive one with albumin. Reduced fetuin-A as well as lower serum kinetics of fetuin-A (HR: 0.55, 95% C.I. 0.34-0.91, p=0.02), adiponectin but not HMWA were independently associated with 28-day mortality adjusting for age, gender, BMI, APACHE II, septic shock and laboratory biomarkers. CONCLUSIONS: Circulating fetuin-A kinetics may be a prognostic biomarker in septic patients. More research is essential to elucidate fetuin-A's ontological role in sepsis pathophysiology.
Kritikou V. La imaginación-fuerza de sobrevivencia en Los ríos profundos de José María Arguedas. In: Estudios y Homenajes Hispanoamericanos V. Vol. 5. 1st ed. Madrid: Ediciones del Orto; 2017. pp. 139-149. kritikou.imaginacion.arguedas.pdf
Konstantinopoulos T, Petkov P, Goasduff A, Arici T, Astier A, Atanasova L, Axiotis M, Bonatsos D, Detistov P, Dewald A, et al. Lifetime measurements in $^{100}\mathrm{Ru}$. Phys. Rev. C. 2017;95:014309.
Panagiotidis P, Spyropoulos V, Revithiadou A. Little v as a categorizing verbal head: Evidence from Greek. In: The Verbal Domain. Oxford: Oxford University Press; 2017. pp. 29-48.Abstract
There is little morphological evidence for little v as a verbalizing head in the literature. Greek, however, exhibits systematic verbalizing morphology and provides us with a strong case study for a robust morphophonological manifestation of the verbalizing v head. Evidence comes from the second-conjugation verbs (e.g., aɣap-ó ‘I love’, ster-ó ‘I deprive’), which display certain distinct morphophonological properties: (a) they take a vocalic extension in certain forms (e.g., aɣáp-i-s-a ‘I loved’) and (b) they exhibit post-root stress, unlike other verb forms (e.g., miní-o ‘I sue’, pal-év-o ‘I fight’). Following Spyropoulos et al. (2015), we argue that both characteristics reflect the morphophonological effects of the exponence of a verbalizing head v by means of an empty vocalic element  V. Furthermore, we provide evidence that a set of verbalizers, almost exclusively identified with a number of derivational suffixes (e.g., -ev, -iz, -(i)az, -on, -ar and -en), are also exponents of this verbalizing v head which is distinct from Voice, is not correlated with agentivity, transitivity and inner aspect / Aktionsart, and, more importantly, do not follow the second conjugation pattern. We propose that the abstract vocalic slot and the verbal derivational suffixes compete for the same morphosyntactic position and that they are both exponents of the verbalizing head v. 
Sagonas K, Kapsalas G, Valakos E, Pafilis P. Living in sympatry: The effect of habitat partitioning on the thermoregulation of three Mediterranean lizards. J Therm Biol. 2017;65:130-137.Abstract
The ability for effective, accurate and precise thermoregulation is of paramount importance for ectotherms. Sympatric lizards often partition their niche and select different microhabitats. These microhabitats, however, usually differ in their thermal conditions and lizards have to adapt their thermoregulation behavior accordingly. Here, we evaluated the impact of habitat partitioning on the thermal biology of three syntopic, congeneric lacertids (Podarcis peloponnesiacus, P. tauricus and P. muralis) from central Peloponnese, Greece. We assessed thermoregulation effectiveness (E) using the three standard thermal parameters: body (Tb), operative (Te) and preferred (Tpref) temperatures. We hypothesized that the microhabitats used by each species would differ in thermal quality. We also predicted that all species would effectively thermoregulate, as they inhabit a thermally challenging mountain habitat. As expected, the partition of the habitat had an effect on the thermoregulation of lizards since microhabitats had different thermal qualities. All three species were effective and accurate thermoregulators but one of them achieved smaller E values as a result of the lower Tb in the field. This discrepancy could be attributed to the cooler (but more benign) thermal microhabitats that this species occupies.
Vassilakis E, Mallinis G, Christopoulou A, Farangitakis GP, Papanikolaou I, Arianoutsou M. Mapping Post-Fire Vegetaτion Recovery at Different Lithologies of Taygetos Mt (Greece) With Multi-Temporal Remote Sensing Data. In: EGU2017-7452. Vol. 19. Vienna, Austria; 2017. posterAbstract
Mt Taygetos (2407m), located at southern Peloponnese (Greece) suffered a large fire during the summer of 2007. The fire burned approximately 45% of the area covered by the endemic Greek fir (Abies cephalonica) and Black Pine (Pinus nigra) forest ecosystems. The aim of the current study is to examine the potential differences on post-fire vegetation recovery imposed by the lithology as well as the geomorphology of the given area over sites of the same climatic and landscape conditions (elevation, aspect, slope etc.). The main lithologies consist of carbonate, permeable, not easily erodible formations (limestones and marbles) and clastic, impermeable (schists, slate and flysch) erodible ones. A time-series of high spatial resolution satellite images were interpreted, analyzed and compared in order to detect changes in vegetation coverage which could prioritize areas of interest for fieldwork campaigns. The remote sensing datasets were acquired before (Ikonos-2), a few months after (Quickbird-2) and some years after (Worldview-3) the 2007 fire. High resolution Digital Elevation Model was used for the ortho-rectification and co-registration of the remote sensing data, but also for the extraction of the mountainous landscape characteristics. The multi-temporal image dataset was analyzed through GEographic-Object Based Image Analysis (GEOBIA). Objects corresponding to different vegetation types through time were identified through spectral and textural features. The classification results were combined with basic layers such as lithological outcrops, pre-fire vegetation, landscape morphology etc., supplementing a spatial geodatabase used for classifying burnt areas with varying post-fire plant community recovery. We validated the results of the classification during fieldwork and found that at a local scale, where the landscape features are quite similar, the bedrock type proves to be an important factor for vegetation recovery, as it clearly defines the soil generation along with its properties. Plant species recovery seems to be controlled by the local lithology as it was found weaker in plots overlying limestones and marbles, comparing to that observed over schists, even for the same species. In conclusion, post-fire vegetation recovery seems to be a complex process controlled not only from species biology, but also from the geological features.
Nastos PT, Karavana Papadimou K, Matsangouras IT. Mediterranean tropical-like cyclones: Impacts and composite daily means and anomalies of synoptic patterns. Atmospheric Research [Internet]. 2017. Website
Karakitsios V, Cornee JJ, Tsourou T, Moissette P, Kontakiotis G, Agiadi K, Manoutsoglou E, Triantaphyllou M, Koskeridou E, DRINIA H, et al. Messinian salinity crisis record under strong freshwater input in marginal, intermediate, and deep environments: The case of the North Aegean. Palaeogeography, Palaeoclimatology, Palaeoecology [Internet]. 2017;485:316-335. Publisher's Version
Mazis I. Methodology for Systemic Geopolitical Analysis according to the Lakatosian model. Global New Positioning: The Importance of Transatlantic Relations, Africa, Near East, Russia and Asia for Greece. 2017.Abstract
The absence of an epistemologically founded geopolitical analysis method that has been internationally observed was the motivation for writing the following contribution. The paper is divided into two parts: i) Definitions and Example analysis and ii) Determination of the Lakatosian Structure of the Systemic Geopolitical Analysis.
lxvi._methodology_for_systemic_geopolitical_analysis_according_to_the_lakatosian_model.pdf
Kontos CK, Tsiakanikas P, Avgeris M, Papadopoulos IN, Scorilas A. miR-15a-5p, A Novel Prognostic Biomarker, Predicting Recurrent Colorectal Adenocarcinoma. Molecular Diagnosis and Therapy. 2017:1-12.
Rapti S-M, Kontos CK, Christodoulou S, Papadopoulos IN, Scorilas A. miR-34a overexpression predicts poor prognostic outcome in colorectal adenocarcinoma, independently of clinicopathological factors with established prognostic value. Clinical Biochemistry [Internet]. 2017:-. WebsiteAbstract
AbstractObjectives MicroRNA-34a (miR-34a) is regulated by \{TP53\} and, in response, downregulates the expression of a gamut of protein-coding genes, including apoptosis regulators, transcription factors, cyclins, and cyclin-dependent kinases. Its upregulation initiates a reprogramming of gene expression and promotes apoptosis. The purpose of this study was the investigation of the potential clinical significance of miR-34a as a molecular prognostic biomarker in colorectal adenocarcinoma using an in-house real-time quantitative \{PCR\} (qPCR) methodology. Design and methods Total \{RNA\} was extracted from 113 primary colorectal adenocarcinoma specimens and 61 paired non-cancerous colorectal tissue samples. After polyadenylation and reverse transcription, miR-34a molecules were determined using qPCR based on \{SYBR\} Green chemistry. Calculations were performed using the comparative \{CT\} method. Finally, extensive biostatistical analysis was performed. Results miR-34a expression does not significantly differ between colorectal adenocarcinoma tissue specimens and adjacent non-cancerous mucosae. However, miR-34a increases progressively as colorectal adenocarcinoma loses its differentiation, being highest in grade İII\} tumors (P = 0.010). Moreover, miR-34a expression is a potential unfavorable prognostic biomarker in colorectal adenocarcinoma, predicting poor disease-free and overall survival (P = 0.002 and P = 0.019, respectively), independently of classical clinicopathological parameters. Most importantly, miR-34a expression stratifies patients without local (N0) and/or distant metastasis (M0) at the time of diagnosis into two groups with substantially different prognosis (P = 0.013 and P = 0.002, respectively). Conclusions High miR-34a levels in colorectal adenocarcinoma predict a rather increased risk for disease recurrence and poor overall survival, particularly in patients at an early \{TNM\} stage. The unfavorable prognostic potential of miR-34a expression is independent of established prognostic features of colorectal adenocarcinoma.
Moschonas IC, Kellici TF, Mavromoustakos T, Stathopoulos P, Tsikaris V, Magafa V, Tzakos AG, Tselepis AD. Molecular requirements involving the human platelet protease-activated receptor-4 mechanism of activation by peptide analogues of its tethered-ligand. Platelets [Internet]. 2017:1 - 10. Website
Paraskevis D, Kostaki E, Nikolopoulos GK, Sypsa V, Psichogiou M, Del Amo J, Hodges-Mameletzis I, Paraskeva D, Skoutelis A, Malliori M, et al. Molecular Tracing of the Geographical Origin of Human Immunodeficiency Virus Type 1 Infection and Patterns of Epidemic Spread Among Migrants Who Inject Drugs in Athens. Clin Infect Dis. 2017;65(12):2078-2084.Abstract
Background: High numbers of human immunodeficiency virus type 1 (HIV-1) infections among people who inject drugs (PWID) have been diagnosed in Athens, Greece, since 2011. We aimed to trace the geographic origin of HIV-1 infection for migrants who inject drugs and to investigate whether transmissions occur more frequently among migrants than among Greek nationals. Methods: Multiple cross-sectional studies were pooled to assemble all persons diagnosed with HIV-1 in Greece between 1 January 2011 and 31 October 2014. Phylogenetic analyses used maximum likelihood estimation. The hypothesis of ethnic compartmentalization was tested by reconstructing ancestral states of characters at the tips using the criterion of parsimony over a set of bootstrap trees. Results: Of 2274 persons, 38.4% were PWID. Phylogenetic analyses showed the existence of 4 major PWID-specific local transmission networks (LTNs): CRF14_BG (437 [58.6%]), CRF35_AD (139 [18.6%]), subtype B (116 [15.6%]), and subtype A (54 [7.2%]). Of 184 non-Greek PWID, 78.3% had been infected within the PWID-LTNs. For 173 (94.3%), the origin of their infection was assumed to be in Greece (postmigration). For PWID infected within LTNs, transmissions for subtype A and CRF14_BG occurred more frequently among migrants than would be expected by chance (phyloethnic study). Conclusions: Our analysis showed that the majority of infections among migrants occurred postmigration. The existence of significant transmission networking among migrants highlights that this population is a priority for HIV prevention. As molecular analysis can estimate the probable country of HIV infection, it can help to inform the design of public health strategies.
Wiessing L, Ferri M, Běláčková V, Carrieri P, Friedman SR, Folch C, Dolan K, Galvin B, Vickerman P, Lazarus JV, et al. Monitoring quality and coverage of harm reduction services for people who use drugs: a consensus study. Harm Reduct J. 2017;14(1):19.Abstract
BACKGROUND AND AIMS: Despite advances in our knowledge of effective services for people who use drugs over the last decades globally, coverage remains poor in most countries, while quality is often unknown. This paper aims to discuss the historical development of successful epidemiological indicators and to present a framework for extending them with additional indicators of coverage and quality of harm reduction services, for monitoring and evaluation at international, national or subnational levels. The ultimate aim is to improve these services in order to reduce health and social problems among people who use drugs, such as human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infection, crime and legal problems, overdose (death) and other morbidity and mortality. METHODS AND RESULTS: The framework was developed collaboratively using consensus methods involving nominal group meetings, review of existing quality standards, repeated email commenting rounds and qualitative analysis of opinions/experiences from a broad range of professionals/experts, including members of civil society and organisations representing people who use drugs. Twelve priority candidate indicators are proposed for opioid agonist therapy (OAT), needle and syringe programmes (NSP) and generic cross-cutting aspects of harm reduction (and potentially other drug) services. Under the specific OAT indicators, priority indicators included 'coverage', 'waiting list time', 'dosage' and 'availability in prisons'. For the specific NSP indicators, the priority indicators included 'coverage', 'number of needles/syringes distributed/collected', 'provision of other drug use paraphernalia' and 'availability in prisons'. Among the generic or cross-cutting indicators the priority indicators were 'infectious diseases counselling and care', 'take away naloxone', 'information on safe use/sex' and 'condoms'. We discuss conditions for the successful development of the suggested indicators and constraints (e.g. funding, ideology). We propose conducting a pilot study to test the feasibility and applicability of the proposed indicators before their scaling up and routine implementation, to evaluate their effectiveness in comparing service coverage and quality across countries. CONCLUSIONS: The establishment of an improved set of validated and internationally agreed upon best practice indicators for monitoring harm reduction service will provide a structural basis for public health and epidemiological studies and support evidence and human rights-based health policies, services and interventions.
Kontakiotis G, Antonarakou A, Mortyn PG, DRINIA H, ANASTASAKIS G, Zarkogiannis S, Möbius  J. Morphological recognition of Globigerinoides ruber morphotypes and their susceptibility to diagenetic alteration in the eastern Mediterranean Sea. Journal of Marine Systems [Internet]. 2017;174:12-24. Publisher's Version
Kamberidou I. The Multiethnic Slavery Institution through the Eyes of Western Women and 'the real position of women in the religious system of Islam' (Second Edition). In: Media, Religion and Gender in Europe. Blanquerna Observatory on Media, Religion and Culture. Faculta de Comunicatio i Relacions Internacionals Blanquerna,Universitat Ramon Llull, Barcelona; 2017. pp. 53-79. 2nd_edition_media_religion_and_gender_in_europe_2017.pdf
Schulpis KH, Thodi G, Iakovou K, Chatzidaki M, Dotsikas Y, Molou E, Triantafylli O, Loukas YL. Mutational analysis of GALT gene in Greek patients with galactosaemia: identification of two novel mutations and clinical evaluation. Scandinavian Journal of Clinical and Laboratory Investigation [Internet]. 2017;77:423-427. Website
Mertzimekis TJ. A New Online Database of Nuclear Electromagnetic Moments. In: ND 2016 International Conference on Nuclear Data for Science and Technology. ; 2017.
Papalampros A, Moris D, Petrou A, Dimitrokallis N, Karavokyros I, Schizas D, Delladetsima I, Pappas TN, Felekouras E. Non-Whipple Operations in the Management of Benign, Premalignant and Early Cancerous Duodenal Lesions. Anticancer Res. 2017;37(3):1443-1452.Abstract
AIM: We reviewed our 20-year experience with non-Whipple operations (pancreas-preserving duodenectomy and transduodenal ampullectomy) for the treatment of benign, premalignant or early-stage malignant duodenal lesions. PATIENTS AND METHODS: Twenty-four patients who underwent non-Whipple operations between January 1996 and December 2015 were identified from an institutional database and retrospectively analyzed. RESULTS: Between 1996 and 2015, 10 patients underwent pancreas-preserving duodenectomy and 14 patients underwent transduodenal ampullectomy. The mean follow-up was 25.8 months (range=6-54 months) and no patient was lost to follow-up. Eighteen patients had preoperative diagnosis of duodenal adenomatosis, three patients had preoperative diagnosis of duodenal adenocarcinoma, one had a bleeding polyp and two had localized inflammation. Average operative time was 145 min (range=127-168 min) for transduodenal ampullectomy and 183 min (range=173-200 min) for pancreas-preserving duodenectomy (p<0.05). The estimated blood loss for transduodenal ampullectomy was 85 vs. 125 ml for pancreas-preserving duodenectomy (p<0.05). Early postoperative complications were noted in 13 cases (54.17%). There were no postoperative (90-day) deaths observed in this series and there were no recurrences during follow-up for the patients operated on with neoplastic lesions. CONCLUSION: For carefully selected patients, transduodenal ampullectomy and pancreas-preserving duodenectomy may be used in place of the Whipple operation for benign and occasionally early-stage malignant (Tis and T1) duodenal and ampullary disease.
Avgoustoglou E, Matsangouras IT, Pytharoulis I, Kamperakis N, Mylonas M, Nastos PT, Bluestein HW. Numerical modeling analysis of the mesoscale environment conducive to two tornado events using the COSMO.Gr model over Greece. Atmospheric Research [Internet]. 2017. Website
Diakakis M, Nikolopoulos E, Mavroulis S, Vassilakis E, Korakaki E. Observational evidence on the effects of mega-fires on the frequency of hydrogeomorphic hazards. The case of the Peloponnese fires of 2007 in Greece. Science of The Total Environment [Internet]. 2017;592:262-276. pdfAbstract
Even though rare, mega-fires raging during very dry and windy conditions, record catastrophic impacts on infrastructure, the environment and human life, as well as extremely high suppression and rehabilitation costs. Apart from the direct consequences, mega-fires induce long-term effects in the geomorphological and hydrological processes, influencing environmental factors that in turn can affect the occurrence of other natural hazards, such as floods and mass movement phenomena. This work focuses on the forest fire of 2007 in Peloponnese, Greece that to date corresponds to the largest fire in the country's record that burnt 1773 km2, causing 78 fatalities and very significant damages in property and infrastructure. Specifically, this work examines the occurrence of flood and mass movement phenomena, before and after this mega-fire and analyses different influencing factors to investigate the degree to which the 2007 fire and/or other parameters have affected their frequency. Observational evidence based on several data sources collected during the period 1989–2016 show that the 2007 fire has contributed to an increase of average flood and mass movement events frequency by approximately 3.3 and 5.6 times respectively. Fire affected areas record a substantial increase in the occurrence of both phenomena, presenting a noticeably stronger increase compared to neighbouring areas that have not been affected. Examination of the monthly occurrence of events showed an increase even in months of the year were rainfall intensity presented decreasing trends. Although no major land use changes has been identified and chlorophyll is shown to recover 2 years after the fire incident, differences on the type of vegetation as tall forest has been substituted with lower vegetation are considered significant drivers for the observed increase in flood and mass movement frequency in the fire affected areas.
Karameta E, Mizan VL, Sagonas K, Sfenthourakis S, Valakos ED, Pafilis P. Ontogenetic shifts in the digestive efficiency of an insectivorous lizard (Squamata: Agamidae). Salamandra [Internet]. 2017;53(2):321 - 326. Website
Mitsopoulos I, Chrysafi I, Mallinis G, Vassilakis E, Arianoutsou M, Lekkas E.

Fire severity estimation using very high spatial resolution satellite imagery: the case of Chios island

. In: 17th Congress of Hellenic Forestry Society. Edessa, Greece; 2017.Abstract
The aim of this study is to spatially assess fire severity and to explore the relationship between the Normalized Vegetation Index (NDVI) derived from WorldView- 2 imagery and the field-based fire severity index “Composite Burn Index” (CBI) on a recent large fire that occurred on the island of Chios, Greece, in 2016. The statistical analysis indicated a relatively strong linear relationship between the NDVI and the CBI (R2 = 0.71). Predictive local thresholds of NDVI values have been determined for accurate thematic classification and mapping of fire severity classes. The overall classification accuracy based on NDVI from WorldView-2 was relatively high (71%), pointing to the potential of using such data for mapping forest fires in the Mediterranean as well as for assessing their severity. The application of the classification thresholds calculated in this study over other forest fire events on similar ecosystem types, could support the rapid assessment of fire severity and hence could enable the decisions needed for proper post-fire management.
Kenourgios D, Dimitriou D, Simos T.

Financial crises, exchange rate linkages and uncovered interest-rate parity: Evidence from G7 markets

. Economic Modelling [Internet]. 2017;66:112-120. Publisher's VersionAbstract
This paper examines the dynamic linkages among major exchange rates during the Global Financial Crisis and Eurozone Sovereign Debt Crisis. We extend the previous literature on volatility spillover linkages among the currencies by taking into account the uncovered interest-rate parity hypothesis for 2004–2015. The results indicate that the Canadian Dollar and Great British Pound were affected mainly by the US Dollar across the two crises due to strong financial and economic ties among the three economies, while the Japanese Yen shows evidence of a safe-haven currency. We also provide evidence of varying vulnerability of currencies to both crises, implying increased portfolio diversification benefits, since holding a portfolio with diverse currencies is less subject to systematic risk. These results show that the policy makers need to adopt a stricter form of monetary policy coordination among central banks, since the different vulnerability of currencies across turbulent periods reveals possible non-cooperative monetary policies.
Pafilis P, Maragou P, Sagonas K, Valakos E. Partitioning thermal habitat on a vertical rock, a herculean task. Journal of Thermal Biology [Internet]. 2017;70:54 - 60. WebsiteAbstract
Abstract Species occurring in sympatry have to effectively segregate their niche in order to co-exist. In the case of ectotherms in particular, the very important parameter of thermal biology has to be taken into account. Here we investigated the thermoregulatory effectiveness (E) of two endemic Greek lizards (Hellenolacerta graeca and Podarcis peloponnesiacus) that live syntopically on a rocky cliff in the Peloponnese. We presumed that the two species would select different microhabitats, to avoid interspecific competition, and follow a similar thermoregulation pattern as they experience the same conditions. We also expected that E values for both species would differ depending on the season. Overall, we found that the two species had similar E values for each season but differentiated partial thermoregulatory attributes. Though they both occurred in the same types of microhabitat, H. graeca selected higher sites (average 99cm above ground) than P. peloponnesiacus (average 44cm). Also, the latter achieved higher preferred temperatures during summer and winter. Finally, the effectiveness of thermoregulation for both species varied interseasonally and received its highest values during summer, in response to the lowest thermal quality that was observed then. Similar studies stress the importance of thermal shifts for ectotherm co-existence.
Mylonas MP, Nastos PT, Matsangouras IT. PBL parameterization schemes sensitivity analysis on WRF modeling of a tornadic event environment in Skala Lakonia in September 2015. Atmospheric Research [Internet]. 2017. Website
Pantazopoulos PA, Stefanou N, Almpanis E, Papanikolaou N. Photomagnonic nanocavities for strong light-spin wave interacton. Physical Review B. 2017;96(10):104425 (9 pages).Abstract
The interaction of visible and near-infrared light with spin waves in appropriately designed dual nanocavities, for both photons and magnons, is investigated by means of rigorous calculations, correct to arbitrary order in the magneto-optical coupling parameter. It is shown that the concurrent localization of the interacting photon and magnon fields in the same region of space for a long period of time enhances their mutual interaction, provided that specific selection rules are fulfilled. Our results provide evidence for the occurrence of strong effects, beyond the linear response approximation, which lead to enhanced modulation of light by spin waves through multimagnon absorption and emission processes by a photon.
Mitsi E. "Picturing the Goddess of Love in Elizabethan Poetry". In: in The Venus Paradox, edited by Loukia Loizou Hadjigavriel, Myrto Hatzaki and Demetra Theodotou Anagnostopoulou. Nicosia: A.G. Leventis Gallery; 2017. pp. 51-59.
Gongaki K. The Platonic myth of Gyges and the concept of justice and injustice in modern-day sport and the contempory world. Electryone [Internet]. 2017;5(2):1-10. Publisher's Version
Oikonomopoulou E-K, Valakos E, Nikita E. Population-specificity of sexual dimorphism in cranial and pelvic traits: evaluation of existing and proposal of new functions for sex assessment in a Greek assemblage. International Journal of Legal Medicine. 2017:1-8.
Peyron O, Combourieu-Nebout N, Brayshaw D, Goring S, Andrieu-Ponel V, Desprat S, Fletcher W, Gambin B, Ioakim C, Joannin S, et al. Precipitation changes in the Mediterranean basin during the Holocene from terrestrial and marine pollen records: a model–data comparison. Climate of the Past [Internet]. 2017;13:249-265. Publisher's VersionAbstract
Climate evolution of the Mediterranean region during the Holocene exhibits strong spatial and temporal variability, which is notoriously difficult for models to reproduce. We propose here a new proxy-based climate synthesis synthesis and its comparison – at a regional (∼ 100 km) level – with a regional climate model to examine (i) opposing northern and southern precipitation regimes and (ii) an east-to-west precipitation dipole during the Holocene across the Mediterranean basin. Using precipitation estimates inferred from marine and terrestrial pollen archives, we focus on the early to mid-Holocene (8000 to 6000 cal yr BP) and the late Holocene (4000 to 2000 cal yr BP), to test these hypotheses on a Mediterranean-wide scale. Special attention was given to the reconstruction of season-specific climate information, notably summer and winter precipitation. The reconstructed climatic trends corroborate the north–south partition of precipitation regimes during the Holocene. During the early Holocene, relatively wet conditions occurred in the south–central and eastern Mediterranean regions, while drier conditions prevailed from 45° N northwards. These patterns then reverse during the late Holocene. With regard to the existence of a west–east precipitation dipole during the Holocene, our results show that the strength of this dipole is strongly linked to the reconstructed seasonal parameter; early-Holocene summers show a clear east–west division, with summer precipitation having been highest in Greece and the eastern Mediterranean and lowest over Italy and the western Mediterranean. Summer precipitation in the east remained above modern values, even during the late-Holocene interval. In contrast, winter precipitation signals are less spatially coherent during the early Holocene but low precipitation is evidenced during the late Holocene. A general drying trend occurred from the early to late Holocene, particularly in the central and eastern Mediterranean.For the same time intervals, pollen-inferred precipitation estimates were compared with model outputs, based on a regional-scale downscaling (HadRM3) of a set of global climate-model simulations (HadAM3). The high-resolution detail achieved through the downscaling is intended to enable a better comparison between site-based paleo-reconstructions and gridded model data in the complex terrain of the Mediterranean; the model outputs and pollen-inferred precipitation estimates show some overall correspondence, though modeled changes are small and at the absolute margins of statistical significance. There are suggestions that the eastern Mediterranean experienced wetter summer conditions than present during the early and late Holocene; the drying trend in winter from the early to the late Holocene also appears to be simulated. The use of this high-resolution regional climate model highlights how the inherently patchy nature of climate signals and paleo-records in the Mediterranean basin may lead to local signals that are much stronger than the large-scale pattern would suggest. Nevertheless, the east-to-west division in summer precipitation seems more marked in the pollen reconstruction than in the model outputs. The footprint of the anomalies (like today, or dry winters and wet summers) has some similarities to modern analogue atmospheric circulation patterns associated with a strong westerly circulation in winter (positive Arctic Oscillation–North Atlantic Oscillation (AO–NAO)) and a weak westerly circulation in summer associated with anticyclonic blocking; however, there also remain important differences between the paleo-simulations and these analogues. The regional climate model, consistent with other global models, does not suggest an extension of the African summer monsoon into the Mediterranean. Therefore, the extent to which summer monsoonal precipitation may have existed in the southern and eastern Mediterranean during the mid-Holocene remains an outstanding question.
Poeschl G, Valentim J, Papastamou S, Chryssochoou X, Prodromitis G, Pavlopoulos V, Mari S, Volpato C. Predictors of the perceived efficacy of actions against austerity measures. International Review of Social Psychology [Internet]. 2017;30(1). doi
Nikolopoulos GK, Christaki E, Paraskevis D, Bonovas S. Pre-Exposure Prophylaxis for HIV: Evidence and Perspectives. Curr Pharm Des. 2017;23(18):2579-2591.Abstract
HIV remains an important public health issue worldwide. However, new prevention approaches have recently been developed and are very promising. Antiretroviral treatment as prevention, or as a prophylaxis after exposure to HIV, has been shown to reduce the likelihood of HIV acquisition. Over the last years, animal studies and randomized clinical trials in humans showed that antiretrovirals can also be efficacious and safe if used once daily, or intermittently, as prophylaxis before an individual is exposed to HIV (Pre-exposure Prophylaxis - PrEP). Fears about development of resistant strains have not been justified insofar given the accumulated evidence from research studies. Demonstration projects are ongoing and first results indicate that interests in the uptake of PrEP are high and adherence is satisfactory. Models suggest that PrEP could be a cost-effective or cost-saving approach under certain provisions including delivery to people at high risk of HIV infection, using less expensive medications, delivery in high HIV prevalence settings, short-term use for periods of higher risk, and evaluation in a longer-term period. The current review summarizes evidence on efficacy, safety and effectiveness of PrEP, and discusses future challenges and perspectives.
Paraskevis D, Kostaki E, Magiorkinis G, Gargalianos P, Xylomenos G, Magiorkinis E, Lazanas M, Chini M, Nikolopoulos G, Skoutelis A, et al. Prevalence of drug resistance among HIV-1 treatment-naive patients in Greece during 2003-2015: Transmitted drug resistance is due to onward transmissions. Infect Genet Evol. 2017;54:183-191.Abstract
BACKGROUND: The prevalence of HIV-1 drug resistance among treatment-naïve patients ranges between 8.3% and 15% in Europe and North America. Previous studies showed that subtypes A and B were the most prevalent in the Greek HIV-1 epidemic. Our aim was to estimate the prevalence of resistance among drug naïve patients in Greece and to investigate the levels of transmission networking among those carrying resistant strains. METHODS: HIV-1 sequences were determined from 3428 drug naïve HIV-1 patients, in Greece sampled during 01/01/2003-30/6/2015. Transmission clusters were estimated by means of phylogenetic analysis including as references sequences from patients failing antiretroviral treatment in Greece and sequences sampled globally. RESULTS: The proportion of sequences with SDRMs was 5.98% (n=205). The most prevalent SDRMs were found for NNRTIs (3.76%), followed by N(t)RTIs (2.28%) and PIs (1.02%). The resistance prevalence was 22.2% based on all mutations associated with resistance estimated using the HIVdb resistance interpretation algorithm. Resistance to NNRTIs was the most common (16.9%) followed by PIs (4.9%) and N(t)RTIs (2.8%). The most frequently observed NNRTI resistant mutations were E138A (7.7%), E138Q (4.0%), K103N (2.3%) and V179D (1.3%). The majority of subtype A sequences (89.7%; 245 out of 273) with the dominant NNRTI resistance mutations (E138A, K103N, E138Q, V179D) were found to belong to monophyletic clusters suggesting regional dispersal. For subtype B, 68.1% (139 out of 204) of resistant strains (E138A, K103N, E138Q V179D) belonged to clusters. For N(t)RTI-resistance, evidence for regional dispersal was found for 27.3% and 21.6% of subtype A and B sequences, respectively. CONCLUSIONS: The TDR rate based on the prevalence of SDRM is lower than the average rate in Europe. However, the prevalence of NNRTI resistance estimated using the HIVdb approach, is high in Greece and it is mostly due to onward transmissions among drug-naïve patients.
Papadavid E, Dalamaga M, Vlami K, Koumaki D, Gyftopoulos S, Christodoulatos GS, Papiris S, Rigopoulos D. Psoriasis is associated with risk of obstructive sleep apnea independently from metabolic parameters and other comorbidities: a large hospital-based case-control study. Sleep Breath. 2017.Abstract
PURPOSE: Obstructive sleep apnea (OSA) represents a breathing disorder during sleep with significant health consequences. Few studies have examined the prevalence of OSA in psoriatic patients and whether OSA may be associated with psoriasis risk. We aimed to explore: (1) the inverse relationship, that is whether psoriasis might represent an independent predictor of OSA and its severity considering important predisposing factors and (2) the psoriatic phenotype related to severe OSA. METHODS: In a large hospital-based case-control study, we examined a total of 253 patients with OSA and a control group of 104 subjects without OSA, who underwent full nocturnal polysomnography and dermatologic examination. RESULTS: The prevalence of psoriasis was significantly greater in OSA patients than in controls (p = 0.03). Psoriasis was associated with OSA risk (p = 0.04) but not severity of OSA, sleepiness severity or sleep efficiency, independently from age, gender, anthropometric features, and significant comorbidities. The phenotype of a psoriatic patient suffering from severe OSA is not different from that of a patient with severe OSA and is not associated with psoriasis severity indexes. OSA psoriatic patients were not compliant with CPAP treatment in comparison with OSA patients without psoriasis. CONCLUSION: Psoriasis may represent an independent risk factor for OSA above and beyond significant comorbidities, anthropometric and metabolic parameters. Physicians should be aware of the bi-directional association of psoriasis and OSA. Managing psoriasis may be a potential target for preventing OSA as well as the potential cardiovascular mortality related to OSA and psoriasis.
Vrontaki E, Mavromoustakos T, Melagraki G, Afantitis A. Quantitative nanostructure-activity relationship models for the risk assessment of nanomaterials. In: Materials Science and Engineering: Concepts, Methodologies, Tools, and Applications. Vol. 1-3. ; 2017. pp. 20 - 44. Website
Hájek R, Masszi T, Petrucci MT, Palumbo A, Rosiñol L, Nagler A, Yong KL, Oriol A, Minarik J, Pour L, et al. A randomized phase III study of carfilzomib vs low-dose corticosteroids with optional cyclophosphamide in relapsed and refractory multiple myeloma (FOCUS). Leukemia [Internet]. 2017;31(1):107 - 114. WebsiteAbstract
This randomized, phase III, open-label, multicenter study compared carfilzomib monotherapy against low-dose corticosteroids and optional cyclophosphamide in relapsed and refractory multiple myeloma (RRMM). Relapsed and refractory multiple myeloma patients were randomized (1:1) to receive carfilzomib (10-min intravenous infusion; 20 mg/m 2 on days 1 and 2 of cycle 1; 27 mg/m 2 thereafter) or a control regimen of low-dose corticosteroids (84 mg of dexamethasone or equivalent corticosteroid) with optional cyclophosphamide (1400 mg) for 28-day cycles. The primary endpoint was overall survival (OS). Three-hundred and fifteen patients were randomized to carfilzomib (n=157) or control (n=158). Both groups had a median of five prior regimens. In the control group, 95% of patients received cyclophosphamide. Median OS was 10.2 (95% confidence interval (CI) 8.4-14.4) vs 10.0 months (95% CI 7.7-12.0) with carfilzomib vs control (hazard ratio=0.975; 95% CI 0.760-1.249; P=0.4172). Progression-free survival was similar between groups; overall response rate was higher with carfilzomib (19.1 vs 11.4%). The most common grade ≥3 adverse events were anemia (25.5 vs 30.7%), thrombocytopenia (24.2 vs 22.2%) and neutropenia (7.6 vs 12.4%) with carfilzomib vs control. Median OS for single-agent carfilzomib was similar to that for an active doublet control regimen in heavily pretreated RRMM patients. © 2017 Macmillan Publishers Limited, part of Springer Nature.
Hájek R, Masszi T, Petrucci MT, Palumbo A, Rosiñol L, Nagler A, Yong KL, Oriol A, Minarik J, Pour L, et al. A randomized phase III study of carfilzomib vs low-dose corticosteroids with optional cyclophosphamide in relapsed and refractory multiple myeloma (FOCUS). Leukemia [Internet]. 2017;31(1):107 - 114. WebsiteAbstract
This randomized, phase III, open-label, multicenter study compared carfilzomib monotherapy against low-dose corticosteroids and optional cyclophosphamide in relapsed and refractory multiple myeloma (RRMM). Relapsed and refractory multiple myeloma patients were randomized (1:1) to receive carfilzomib (10-min intravenous infusion; 20 mg/m 2 on days 1 and 2 of cycle 1; 27 mg/m 2 thereafter) or a control regimen of low-dose corticosteroids (84 mg of dexamethasone or equivalent corticosteroid) with optional cyclophosphamide (1400 mg) for 28-day cycles. The primary endpoint was overall survival (OS). Three-hundred and fifteen patients were randomized to carfilzomib (n=157) or control (n=158). Both groups had a median of five prior regimens. In the control group, 95% of patients received cyclophosphamide. Median OS was 10.2 (95% confidence interval (CI) 8.4-14.4) vs 10.0 months (95% CI 7.7-12.0) with carfilzomib vs control (hazard ratio=0.975; 95% CI 0.760-1.249; P=0.4172). Progression-free survival was similar between groups; overall response rate was higher with carfilzomib (19.1 vs 11.4%). The most common grade ≥3 adverse events were anemia (25.5 vs 30.7%), thrombocytopenia (24.2 vs 22.2%) and neutropenia (7.6 vs 12.4%) with carfilzomib vs control. Median OS for single-agent carfilzomib was similar to that for an active doublet control regimen in heavily pretreated RRMM patients. © 2017 Macmillan Publishers Limited, part of Springer Nature.
Sypsa V, Psichogiou M, Paraskevis D, Nikolopoulos G, Tsiara C, Paraskeva D, Micha K, Malliori M, Pharris A, Wiessing L, et al. Rapid Decline in HIV Incidence Among Persons Who Inject Drugs During a Fast-Track Combination Prevention Program After an HIV Outbreak in Athens. J Infect Dis. 2017;215(10):1496-1505.Abstract
Background.: A "seek-test-treat" intervention (ARISTOTLE) was implemented in response to an outbreak of human immunodeficiency virus (HIV) infection among persons who inject drugs (PWID) in Athens. We assess trends in HIV incidence, prevalence, risk behaviors and access to prevention/treatment. Methods.: Methods included behavioral data collection, provision of injection equipment, HIV testing, linkage to opioid substitution treatment (OST) programs and HIV care during 5 rounds of respondent-driven sampling (2012-2013). HIV incidence was estimated from observed seroconversions. Results.: Estimated coverage of the target population was 88% (71%-100%; 7113 questionnaires/blood samples from 3320 PWID). The prevalence of HIV infection was 16.5%. The incidence per 100 person-years decreased from 7.8 (95% confidence interval, 4.6-13.1) (2012) to 1.7 (0.55-5.31) (2013; P for trend = .001). Risk factors for seroconversion were frequency of injection, homelessness, and history of imprisonment. Injection at least once daily declined from 45.2% to 18.8% (P < .001) and from 36.8% to 26.0% (P = .007) for sharing syringes, and the proportion of undiagnosed HIV infection declined from 84.3% to 15.0% (P < .001). Current OST increased from 12.2% to 27.7% (P < .001), and 48.4% of unlinked seropositive participants were linked to HIV care through 2013. Repeat participants reported higher rates of adequate syringe coverage, linkage to HIV care and OST. Conclusions.: Multiple evidence-based interventions delivered through rapid recruitment in a large proportion of the population of PWID are likely to have helped mitigate this HIV outbreak.
Schulpis KH, Thodi G, Chatzidaki M, Iakovou K, Molou E, Dotsikas Y, Loukas YL. Rare cases of galactose metabolic disorders: Identification of more than two mutations per patient. Journal of Pediatric Endocrinology and Metabolism [Internet]. 2017;30:1119-1120. Website
Kellici TF, Chatziathanasiadou MV, Lee M-S, Sayyad N, Geromichalou EG, Vrettos EI, Tsiailanis AD, Chi S-W, Geromichalos GD, Mavromoustakos T, et al. Rational design and structure-activity relationship studies of quercetin-amino acid hybrids targeting the anti-apoptotic protein Bcl-xL. Organic and Biomolecular Chemistry [Internet]. 2017;15(37):7956 - 7976. Website
Mazis I. The rationale of NATO founding and N.J. Spykman’s geopolitical example. Regional Science Inquiry. 2017;IX(1).Abstract
The foundation of NATO on April 4th, 1949 marked in the most exquisite manner the disintegration of the alliance of the US, Great Britain and USSR which lasted during WWII. At the same time it coincided with the introduction of a new post-war system of power equilibrium, with the Cold War as its main characteristic. This total geopolitical confrontation of the two superpowers and their respective satellites extended around the globe, begun in the ruins of post-war Europe, where the long-standing geopolitical ambitions of both sides manifested themselves, reinforced through the reproduction of established myths and stereotypes, as well as national interests. This power equilibrium was based on the framework of values and principles put forth by the UN Charter in 1945 as the bedrock of the postwar international system. The guiding principles of the UN Charter prescribe the delegitimization of the use of violence in international relations as an accepted way of solving international disputes (Articles 2.3 and 2.4), respect of the domestic jurisdiction of any state (Article 2.7), and the right of self-defense, even in its version of collective self defense, as defined in Article 51 (and thereafter in the corresponding Article 5 of the NATO Charter and the corresponding provisions of the Warsaw Pact). The new post-war world order was built amidst an atmosphere of insecurity, fear, distrust and even hate, emanating from both sides. As a consequence Germany was divided between two states, while the whole of Europe was divided between two blocs. The so-called West and the USSR came to a confrontation through the blockade of Berlin by the Soviets (1948-1949). It was during that period that ΝΑΤΟ was created.
lxv._the_rationale_of_nato_founding_and_n.j._spykmans_geopolitical_example.pdf rsi_june_2017_ix_1.pdf
Oikonomopoulou M, Demetriou VL, Kostrikis LG, Paraskevis D. Re-analysis of unassigned hepatitis C virus (HCV) strain CYHCV025: Evidence of a highly divergent lineage within genotype 1. Mol Phylogenet Evol. 2017;109:362-366.Abstract
HCV global sequences have been classified into 7 genotypes, several subtypes and a number of unassigned sequences. Our aim was to perform an in depth investigation of the taxonomic relationships of the unclassified CYHCV025 strain by means of phylogenetic analysis. Phylogenetic tree reconstructions were performed using ML methods on full-length genomic and partial HCV alignments. Phylogenetic analysis of full-length sequences revealed that CYHCV025 clustered close to the root node of genotype 1, showing distant genetic relationships to all previously classified subtypes and unclassified sequences. Single section analysis using the SSE showed that the distances between the query and all subtypes were much higher than distances within and between subtypes of genotype 1 (p<0.05). Recombination analysis revealed no evidence for intersubtype or genetic mixing between the query and the references from different genotype 1 subtypes. Different analyses revealed that CYHCV025 is the most genetically divergent within genotype 1, showing no high- or low-level clustering with any of the previous subtypes or unclassified sequences. Identification of a single lineage within a genotype without any late branching can be explained by "genetic isolation" until the late stage of HCV epidemic spread.
Psichogiou M, Poulakou G, Basoulis D, Paraskevis D, Markogiannakis A, Daikos GL. Recent Advances in Antiretroviral Agents: Potent Integrase Inhibitors. Curr Pharm Des. 2017;23(18):2552-2567.Abstract
Integrase strand transfer inhibitors (INSTIs) belong to a novel class of antiretroviral agents that have emerged as the new first-line treatments. Three such compounds are currently available, raltegravir, elvitegravir, dolutegravir and two more under development, bictegravir and cabotegravir. These compounds share the same mode of action but exhibit different pharmacokinetic/ pharmacodynamic properties, and drug-drug interactions. A series of studies in the past decade have established their efficacy compared to previous regimens, both in treatment- naïve and experienced patients. INSTIs have demonstrated a favorable safety profile with fewer adverse events and low rates of virological failure. Emergence of resistance to these agents, however, is a worrying concern, particularly for elvitegravir and raltegravir that display a lower genetic barrier than dolutegravir. On-going trials aim at establishing INSTIs as part of dual-drug HIV treatments or even monotherapy. New long-acting, injectable formulations are under investigation for treatment or prevention.
Moris D, Karamagioli E, Karavokyros I, Angelou A, Pikoulis E. Refugee crisis in Greece: The National and Kapodistrian University of Athens paves the way to meet the challenge. Ann Transl Med. 2017;5(15):316.
Papaioannou TG, Karageorgopoulou TD, Sergentanis TN, Protogerou AD, Psaltopoulou T, Sharman JE, Weber T, Blacher J, Daskalopoulou SS, Wassertheurer S, et al. Reply. J Hypertens. 2017;35:894-896.
Aissopou EK, Protogerou AD, Papaioannou TG, Tektonidou M, Tentolouris N, Theodossiadis PG, Stehouwer CDA, Kitas GD, Sfikakis PP. Retinal vascular calibers in contemporary patients with chronic systemic inflammatory diseases: The Greek REtinal Microcirculation (GREM) study. Artery Research [Internet]. 2017;18:1 - 6. Website
Vrontaki E, Melagraki G, Afantitis A, Mavromoustakos T, Kollias G. Searching for novel janus kinase-2 inhibitors using a combination of pharmacophore modeling, 3D-QSAR studies and virtual screening. Mini-Reviews in Medicinal Chemistry [Internet]. 2017;17(3):268 - 294. Website
Pafilis P, Sagonas K, Kapsalas G, Foufopoulos J, Valakos ED. Sex does not affect tail autotomy in lacertid lizards. Acta Herpetologica. 2017;12(1):19-27.
Toumazatou A, Arfanis MK, Pantazopoulos PA, Kontos AG, Falaras P, Stefanou N, Likodimos V. Slow-photon enhancement of dye sensitized TiO2 photocatalysis. Materials Letters. 2017;197:123-126.Abstract
Photonic band gap engineered TiO2 inverse opals were fabricated using self- assembled polystyrene films as sacrificial templates with controlled optical properties, aimed at the identification of the slow-photon effect on dye sensitized TiO2 photocatalysis. The materials’ photocatalytic efficiency was evaluated using Raman spectroscopy, on methylene blue photodegradation following both UVA and monochromatic visible light illumination. Contrary to UVA, where no photonic effect could be traced, laser irradiation within the slow-photon energy range of the TiO2 inverse opals, resulted in a marked increase of the dye photosensitized degradation rate, outperforming not only compact nanocrystalline films but also the benchmark mesoporous Aeroxide® P25 TiO2 films. This effect provides direct evidence for the presence of slow photons that amplify the interaction of visible light with the adsorbed dye molecules on the periodically structured TiO2 film.
Giannopoulos N, Vagenas G, Noutsos K, Barzouka K, Bergeles N. Somatotype, Level of Competition, and Performance in Attack in Elite Male Volleyball. Journal of Human Kinetics [Internet]. 2017;58:131-140. Publisher's VersionAbstract
This study investigated the relationship between somatotype, level of competition, and performance in attack in elite level male volleyball players. The objective was to test for the potential covariation of competition level (Division A1 vs. A2) and playing position (hitters vs. centers vs. opposites) considering performance in attack. Anthropometric, body composition and somatotype variables were measured according to the Heath-Carter method. The attack actions of 144 players from 48 volleyball matches were analyzed and their performance was rated using a 5-point numerical scale. Results showed that players of Division A1 were taller, heavier, more muscular, and less endomorphic compared to those of Division A2. MANOVA and follow-up discriminant function analysis revealed somatotype differences among playing positions with centers and opposites being endomorph-ectomorph and hitters being central. Centers performed constantly better than hitters and opposites regardless of division and somatotype. Multiple linear regression analysis showed that variables defining ectomorph and endomorph players, centers, and players of Division A1 significantly determined the relative performance superiority and were able to explain the variation in performance by almost 25%. These results could be taken into account by coaches when assigning players to particular playing positions or when designing individualized position-specific training programs.
giannop_vagen_bergel_2017.pdf
<span style="font-family: Arial; font-size: small;"><em>Inlerlingual Perspectives<br />Διαγλωσσικές Θεωρήσεις<br /></em></span>
Inlerlingual Perspectives
Διαγλωσσικές Θεωρήσεις
. 1st ed. (Sidiropoulou M). Athens: National and Kapodistrian University of Athens/The Meta-fraseis Translation Programme; 2017 pp. 1-509. Publisher's VersionAbstract
Inlerlingual Perspectives (http://en.metafraseis.enl.uoa.gr/interlingual-perspectives-e-volume/contents-of-the-e-volume.html)/Διαγλωσσικές Θεωρήσεις (http://metafraseis.enl.uoa.gr/metafraseologikos-h-tomos-diaglwssikes-8ewrhseis/periexomena-toy-h-tomoy.html) is a bilingual e-volume comprising occasional research articles (2010- ) focusing on the interaction of Greek with other languages through translation. Ιt invites contributions from various theoretical perspectives in translation studies (and beyond) which may shed light to the study of phenomena that are treated diffrerently cross-culturally.  The volume invites original research papers which highlight socio-cultural features of Greek in juxtaposition to other languages, as traced through translation of any type of genre: political, literary, theatrical, scientific, commercial, technical etc.   It foregrounds the potential of translators to register, in discourse, perspectives which realize dominant (or peripheral) ideological positions or narratives reverberating in a target society, whether public narratives or personal socio-political positions. The e-volume welcomes perspectives drawing on various theoretical approaches in translation studies, which may shed light on aspects of the difference of Greek vs. other languages (not necessarily the hegemonic ones). The e-volume hopes to broaden perception of interlingual variation as it is manifested through translation or interpreting. Highlighting difference in a translation context foregrounds aspects of the character of Greek vs. those of other languages, contriburing to identity awareness, aspects of translators' roles highlighting their potential to affect target culture (and the responsibility this potential assumes), while it develops competencies (professional and/or linguitic) in both languages.
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Arianoutsou Μ, Mitsopoulos Ι, Vallatou Μ, Vassilakis Ε, Mallinis G. A spatial modeling approach to assess fire risk and exposure of biodiversity hotspots in Cephalonia island, Greece. In: XIV MEDECOS & XIII AEET meeting. Seville, Spain; 2017. pp. 16.Abstract
Recent global changes seem to have affected fire regimes by inducing more severe larger fires in the thermomediterranean vegetation zone but also more frequent incidents in territories of higher altitudes. Cephalonia island hosts Mt Ainos, one of the most important National Parks of Greece, focal geographical area of the non-fire adapted endemic fir Abies cephalonica. The island has suffered several fires in the past. The aim of this work is to introduce a framework for assessing spatial fire risk and exposure of biodiversity hot spot areas, using Cephalonia as a pilot case study. Fuel parameters in representative vegetation types were measured across the island for models development as well as for collecting training and validation points for satellite data classification. The Minimum Travel Time algorithm, as it is embedded in FlamMap spatial fire simulation software, was applied in order to assess critical fire behavior parameters and exposure of the island’s biodiversity hotspots under three different meteorological and fuel moisture scenarios simulating predicted climate changes. In addition, the risk of change in the island's ecological value due to biodiversity loss was studied under the same scenarios. According to the analysis, loss of all biodiversity values was found under the severe meteorological and fuel moisture scenario and was estimated to be higher in the endemic fir forests. The outputs of this study may be used as an application of quantitative and probabilistic risk assessment for biodiversity conservation planning, prioritization and management of high value natural and cultural resources.
Burnetas A, Economou A, Vasiliadis G. Strategic customer behavior in a queueing system with delayed observations. Queueing Systems [Internet]. 2017:1-30. WebsiteAbstract
We consider the single-server Markovian queue with infinite waiting space and assume that there exists a certain reward-cost structure that reflects the customers’ desire for service and their dislike for waiting. The system is unobservable for the customers at their arrival instants, but the administrator provides them with periodic announcements of their current positions at rate (Formula presented.), so that they may renege if it is preferable for them to do so. The customers are strategic, and their decision problem is whether to join or not the system upon arrival and whether to stay or renege later. Their strategies are specified by a join probability q and a reneging threshold n. We determine the equilibrium strategies (Formula presented.) and study the socially optimal strategies (Formula presented.). Extensive numerical experiments provide interesting qualitative insight about the model. In particular, the equilibrium throughput of the system is a unimodal function of (Formula presented.). Moreover, despite the fact that we have an avoid-the-crowd situation, it is possible that (Formula presented.), in contrast to the classical unobservable model. © 2017 Springer Science+Business Media New York
Norström E, Katrantsiotis C, Smittenberg RH, Kouli K. Chemotaxonomy in some Mediterranean plants and implications for fossil biomarker records. Geochimica et Cosmochimica Acta [Internet]. 2017;219:96-110. Publisher's VersionAbstract
The increasing utilization of n-alkanes as plant-derived paleo-environmental proxies calls for improved chemotaxonomic control of the modern flora in order to calibrate fossil sediment records to modern analogues. Several recent studies have investigated long-chain n-alkane concentrations and chain-length distributions in species from various vegetation biomes, but up to date, the Mediterranean flora is relatively unexplored in this respect. Here, we analyse the n-alkane concentrations and chain-length distributions in some of the most common species of the modern macchia and phrygana vegetation in south western Peloponnese, Greece. We show that the drought adapted phrygana herbs and shrubs, as well as some of the sclerophyll and gymnosperm macchia components, produce high concentrations of n-alkanes, on average more than double n-alkane production in local wetland reed vegetation. Furthermore, the chain-length distribution in the analysed plants is related to plant functionality, with longer chain lengths associated with higher drought adaptive capacities, probably as a response to long-term evolutionary processes in a moisture limited environment. Furthermore, species with relatively higher average chain lengths (ACL) showed more enriched carbon isotope composition in their tissues (δ13Cplant), suggesting a dual imprint from both physiological and biochemical drought adaptation. The findings have bearings on interpretation of fossil sedimentary biomarker records in the Mediterranean region, which is discussed in relation to a case study from Agios Floros fen, Messenian plain, Peloponnese. The 6000 year long n-alkane record from Agios Floros (ACL, δ13Cwax) is linked to the modern analogue and then evaluated through a comparison with other regional-wide as well as local climate and vegetation proxy-data. The high concentration of long chain n-alkanes in phrygana vegetation suggests a dominating imprint from this vegetation type in sedimentary archives from this ecotone.
Bathrellos GD, Skilodimou HD, Maroukian H, Gaki-Papanastasiou K, Kouli K. Pleistocene glacial and lacustrine activity in the southern part of Mount Olympus (central Greece. Area [Internet]. 2017;49(2):137-147. Publisher's Version
Hatzaki M, Bitsa E, Flocas HA, Kouroutzoglou J, Garde L, Simmonds I. Study of cold anticyclones generating in the Mediterranean. In: Karacostas T, Bais A, Nastos PT Perspectives on Atmospheric Sciences. 1st ed. Springer International Publishing; 2017. pp. 515–520.
Koukoula M, Dotsikas Y, Molou E, Schulpis KH, Thodi G, Chatzidaki M, Triantafylli O, Loukas YL. Study of the effect of CYP2C19 polymorphisms on omeprazole pharmacokinetics by utilizing validated LC–MS/MS and Real Time-PCR methods. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences [Internet]. 2017;1047:173-179. Website
Papadaki GF, Amillis S, Diallinas G. Substrate Specificity of the FurE Transporter Is Determined by Cytoplasmic Terminal Domain Interactions. Genetics. 2017.Abstract
FurE, a member of the NCS1 transporter family in Aspergillus nidulans, is specific for allantoin, uric acid, uracil and related analogues. Herein, we show that C- or N-terminally truncated FurE transporters (FurE-ΔC or FurE-ΔΝ) present increased protein stability, but also inability for uric acid transport. To better understand the role of cytoplasmic terminal regions, we characterized genetic suppressors that restore FurE-ΔC-mediated uric acid transport. Suppressors map in the periphery of the substrate-binding site (Thr133 in TMS3 and Val343 in TMS8), an outward-facing gate (Ser296 in TMS7, Ile371 in TMS9, Tyr392 and Leu394 in TMS10) or in flexible loops (Asp26 in LN, Gly222 in L5, Asn308 in L7). Selected suppressors were shown to also restore the wild-type specificity of FurE-ΔΝ, suggesting that both C- and/or N-terminal domains are involved in intramolecular dynamics critical for substrate selection. A direct, substrate-sensitive, interaction of C- and/or N-terminal domains was supported by bimolecular fluorescence complementation assays. To our knowledge, this is the first case where not only the function, but also, the specificity of a eukaryotic transporter is regulated by its terminal cytoplasmic regions.
Raptopoulos G, Anyfantis GC, Chriti D, Paraskevopoulou P. Synthesis and structural characterization of poly (dicyclopentadiene) gels obtained with a novel ditungsten versus conventional W and Ru mononuclear catalysts. Inorganica Chimica Acta. 2017;460:69-76.
Weisel K, Doyen C, Dimopoulos M, Yee A, Lahuerta JJ, Martin A, Travers K, Druyts E, Toor K, Abildgaard N, et al. A systematic literature review and network meta-analysis of treatments for patients with untreated multiple myeloma not eligible for stem cell transplantation. Leukemia and Lymphoma [Internet]. 2017;58(1):153 - 161. WebsiteAbstract
In newly diagnosed multiple myeloma (MM), patients ineligible for front-line autologous stem cell transplantation (ASCT), melphalan and prednisone (MP) with thalidomide (MPT) or bortezomib (VMP) are standard first-line therapeutic options. Despite new treatment regimens incorporating bortezomib or lenalidomide, MM remains incurable. The FIRST study demonstrated significant improvement in progression-free survival (PFS) and overall survival (OS) for the combination of lenalidomide and low-dose dexamethasone (Rd) until progression vs. MPT in transplant-ineligible ndMM patients. However, to date no head-to-head randomized controlled trials (RCTs) have compared Rd or MPT versus VMP. We conducted a network meta-analysis using RCTs identified through a systematic literature review to evaluate the relative efficacy of Rd versus other regimens on survival endpoints in previously untreated MM patients ineligible for ASCT. In this analysis, Rd was associated with a significant PFS and survival advantage versus other first-line treatments (VMP, MPT, MP), challenging the role of alkylators in this setting. © 2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
Weisel K, Doyen C, Dimopoulos M, Yee A, Lahuerta JJ, Martin A, Travers K, Druyts E, Toor K, Abildgaard N, et al. A systematic literature review and network meta-analysis of treatments for patients with untreated multiple myeloma not eligible for stem cell transplantation. Leukemia and Lymphoma [Internet]. 2017;58(1):153 - 161. WebsiteAbstract
In newly diagnosed multiple myeloma (MM), patients ineligible for front-line autologous stem cell transplantation (ASCT), melphalan and prednisone (MP) with thalidomide (MPT) or bortezomib (VMP) are standard first-line therapeutic options. Despite new treatment regimens incorporating bortezomib or lenalidomide, MM remains incurable. The FIRST study demonstrated significant improvement in progression-free survival (PFS) and overall survival (OS) for the combination of lenalidomide and low-dose dexamethasone (Rd) until progression vs. MPT in transplant-ineligible ndMM patients. However, to date no head-to-head randomized controlled trials (RCTs) have compared Rd or MPT versus VMP. We conducted a network meta-analysis using RCTs identified through a systematic literature review to evaluate the relative efficacy of Rd versus other regimens on survival endpoints in previously untreated MM patients ineligible for ASCT. In this analysis, Rd was associated with a significant PFS and survival advantage versus other first-line treatments (VMP, MPT, MP), challenging the role of alkylators in this setting. © 2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
Sagonas K, Karambotsi N, Bletsa A, Reppa A, Pafilis P, Valakos ED. Tail regeneration affects the digestive performance of a Mediterranean lizard. Naturwissenschaften. 2017;104(3-4):22.Abstract
In caudal autotomy, lizards shed their tail to escape from an attacking predator. Since the tail serves multiple functions, caudal regeneration is of pivotal importance. However, it is a demanding procedure that requires substantial energy and nutrients. Therefore, lizards have to increase energy income to fuel the extraordinary requirements of the regenerating tail. We presumed that autotomized lizards would adjust their digestion to acquire this additional energy. To clarify the effects of tail regeneration on digestion, we compared the digestive performance before autotomy, during regeneration, and after its completion. Tail regeneration indeed increased gut passage time but did not affect digestive performance in a uniform pattern: though protein income was maximized, lipid and sugar acquisition remained stable. This divergence in proteins may be attributed to their particular role in tail reconstruction, as they are the main building blocks for tissue formation.
Despotopoulou A. "Terrible Traps to Memory": National Monuments, Collective Memory, and Women in Henry James. Modern Fiction Studies. 2017;63(3):429-451.
Kamberidou I, Karteroliotis K, Venetsanou F, Dania A. THINKING GLOBALLY AND ACTING LOCALLY: THE POWER OF PLAY AND GAMES. Creating a tech tool to promote European Traditional Sports and Games from an intergenerational and inclusive perspective, ERASMUS PLUS Small Collaborative Partnership-GEO-LUDENS:Discussion-proposals for 1st meeting in Zaragoza Spain, 9-10/2/ 2017. 2017;(GEO-LUDENS partnership, Zaragoza Spain,).Abstract
Creating a tech tool to promote European Traditional Sports and Games from an intergenerational and inclusive perspective, ERASMUS PLUS Small Collaborative Partnership-GEO-LUDENS:  ©Discussion-proposals-Greek team’s contribution for upcoming meetings in Zaragoza Spain, Feb. 9-10, 2017***Also attached: Kick-off MEETING AGENDA, 9-10 February, 2017.  Universidad San Jorge. Campus Villanueva de Gállego (Zaragoza), Spain
thinking_globally_and_acting_locally.pdf geo_ludens_kickoffmeeting_agenda_2017.pdf
Kountouris P, Angelonidis I, Drikos S. Time characteristics of four consecutive Olympic Volleyball Games after the implementation of the new regulations. Journal of Physical Activity, Nutrition and Rehabilitation [Internet]. 2017:190-198. Publisher's VersionAbstract
The purpose of the present study was to investigate the time characteristics four consecutive Olympic Games after the implementation of the new regulations, both in men and women. Data concerns the points and the duration of the set and the match as well and the total match duration, from Olympic volleyball games (Sidney 2000, Athens 2004, Beijing 2008 and London 2012). In total 312 matches were analyzed. Results indicated a continuous significant increase in the set and accordingly match duration's, both in men and women. Overall the mean set duration for each of the first four sets increased from around 22 minutes in Sydney to 26 minutes in London and the fifth sets increased from around 15 minutes to 17.5 minutes respectively. This may be is a consequence of the teams’ primary commitment to performance improvement in the defense tactics and the special attention given to the avoidance of faults. In conclusion, the implementation of the new rules since 2000, especially those related with the change to the rally point system, with each set played to 25 points and the introduction of rule for libero player have forced volleyball coaches and players to reevaluate their strategies and tactics in the goal of winning a rally, a set and a game. The collateral prolongation of the rallies and the increased uncertainty of the outcome have undeniably made the game more spectacular and intriguing to watch.Keywords: Volleyball; Time characteristics; Rules.
panrar_16015.pdf
Papaioannou TG, Protogerou AD, Argyris A, Aissopou E, Georgiopoulos G, Nasothimiou E, Tountas C, Sfikakis PP, Stergiopulos N, Tousoulis D. Total arterial compliance, estimated by a novel method, is better related to left ventricular mass compared to aortic pulse wave velocity: The SAFAR study. Clin Exp Hypertens. 2017;39(3):271-276.Abstract
AIM: The investigation of the association between total arterial compliance (CT)-estimated by a novel technique-with left ventricular mass (LVM) and hypertrophy (LVH). Our hypothesis was that CT may be better related to LVM compared to the gold-standard regional aortic stiffness. Within the frame of the ongoing cross-sectional study "SAFAR," 226 subjects with established hypertension or with suspected hypertension underwent blood pressure (BP) assessment, carotid-to-femoral pulse wave velocity (cf-PWV), and echocardiographic measurement of LVM. LVM index (LVMI) was calculated by the ratio of LVM to body surface area. CT was estimated by a previously proposed and validated formula: CT = 36.7 /cf-PWV2 [ml/mmHg]. LVMI was related to age (r = 0.207, p = 0.002), systolic BP (r = 0.248, p < 0.001), diastolic BP (r = 0.139, p = 0.04), mean BP (r = 0.212, p = 0.002), pulse pressure (r = 0.212, p = 0.002), heart rate (r = -0.172, p = 0.011), cf-PWV (r = 0.268, p < 0.001), and CT (r = -0.317, p < 0.001). The highest correlation was observed for CT that was significantly stronger than the respective correlation of cf-PWV (p < 0.001). In multivariate analysis, CT was a stronger determinant, compared to cf-PWV, of LVMI and LVH. It remains to be further explored whether CT has also a superior prognostic value beyond and above local or regional (segmental) estimates of pulse wave velocity.
Griniatsos J, Moris D, Spartalis E, Gakiopoulou H, Karavokyros I, Apostolou K, Dimitriou N, Felekouras E. Towards a tailored lymphadenectomy for gastric cancer based on the correlation between the primary tumor location and the first lymphatic drain basin: Preliminary data. J BUON. 2017;22(5):1137-1143.Abstract
PURPOSE: The contradictory long-term results following D2 lymphadenectomy have revealed the necessity for a more tailored lymphadenectomy in cases of gastric cancer. Among the patients who had undergone a modified D2 lymphadenectomy for gastric cancer, we further analyzed the subgroup in which histologically and immunohistochemically solitary lymph node metastases were detected. Classifying the primary tumors as towards to the lesser and towards to the grater curvature, we propose possible routes of lymphatic spread and possible clinical implications. METHOD: Between January 2007 and December 2016, 212 patients suffering from gastric adenocarcinoma underwent a modified D2 lymphadenectomy. Solitary lymph node metastases were detected by histology in 14 patients (7 skip metastases) and by immunohistochemistry in an additional 10 patients (5 skip micrometastases). RESULTS: The incidence of the histologically detected solitary lymph node metastases was 6.6% for the whole cohort, increasing to 11.3% with the use of immunohistochemistry. The incidence of the histologically detected skip solitary lymph node metastases was 3.3% for the whole cohort, increasing to 5.7% with the use of immunohistochemistry. Tumors of the lower and middle third of the stomach were equally drained both to the level I and II lymph node stations. However, tumors towards the lesser curvature were mainly drained in the level II lymph node stations (12 out of 19; 63%), while tumors towards the greater curvature were all drained in the level I lymph node stations (5 out of 5; 100%). CONCLUSION: Primary gastric tumors towards the lesser curvature should be treated by a modified D2 lymphadenctomy. However, for tumors towards the greater curvature, a D1(+) lymphadenectomy always including the no. 7 & 9 lymph node stations complex, might be enough.
Paraskevis D, Kostaki E, Gargalianos P, Xylomenos G, Lazanas M, Chini M, Skoutelis A, Papastamopoulos V, Paraskeva D, Antoniadou A, et al. Transmission Dynamics of HIV-1 Drug Resistance among Treatment-Naïve Individuals in Greece: The Added Value of Molecular Epidemiology to Public Health. Genes (Basel). 2017;8(11).Abstract
The presence of human immunodeficiency virus type 1 (HIV-1) drug resistance among drug-naïve patients remains stable, although the proportion of patients with virological failure to therapy is decreasing. The dynamics of transmitted resistance among drug-naïve patients remains largely unknown. The prevalence of non-nucleoside reverse transcriptase inhibitors (NNRTI) resistance was 16.9% among treatment-naïve individuals in Greece. We aimed to investigate the transmission dynamics and the effective reproductive number () of the locally transmitted NNRTI resistance. We analyzed sequences with dominant NNRTI resistance mutations (E138A and K103N) found within monophyletic clusters (local transmission networks (LTNs)) from patients in Greece. For the K103N LTN, thewas >1 between 2008 and the first half of 2013. For all E138A LTNs, thewas >1 between 1998 and 2015, except the most recent one (E138A_4), where thewas >1 between 2006 and 2011 and approximately equal to 1 thereafter. K103N and E138A_4 showed similar characteristics with a more recent origin, higherduring the first years of the sub-epidemics, and a declining trend in the number of transmissions during the last two years. In the remaining LTNs the epidemic was still expanding. Our study highlights the added value of molecular epidemiology to public health.
Macek J, Macková A, Pavlopoulos V, Kalmus V, Elavsky MC, Šerek J. Trust in alternative and professional media: The case of the youth news audiences in three European countries. European Journal of Developmental Psychology [Internet]. 2017:1-15. doi
ATHANASSOPOULOU EKAVI. Turkey's Approach Towards Israel in the 1950s: Not Merely Following US policy. Middle Eastern Studies [Internet]. 2017;53(6):899-914. Publisher's VersionAbstract
Within the context of Turkey's relationship with Israel, the 1950s are remembered largely as the decade when bilateral relations developed dramatically reflecting the US orientation of Adnan Menderes's foreign policy. On closer observation, however, one cannot fail to notice that there was more ebb than flow in Turkey's policy towards Israel which already assumed the double-faced profile (cold or reproachful in public/positive behind closed doors), which is usually associated with the next two decades. Drawing on substantial research in official US and British archives, this article explores the multiple considerations which informed the approach of the Menderes government towards Tel-Aviv. Crucially, it places the Turks’ approach within their broader Middle Eastern policy with the aim of showing that it was shaped not only by their relationship with their powerful ally, the United States, but also by the need to look after relations with neighbourly Arab regimes.
Vrettos EI, Sayyad N, Mavrogiannaki EM, Stylos E, Kostagianni AD, Papas S, Mavromoustakos T, Theodorou V, Tzakos AG. Unveiling and tackling guanidinium peptide coupling reagent side reactions towards the development of peptide-drug conjugates. RSC Advances [Internet]. 2017;7(80):50519 - 50526. Website
Diamantopoulos MA, Kontos CK, Kerimis D, Papadopoulos IN, Scorilas A. Upregulated miR-16 expression is an independent indicator of relapse and poor overall survival of colorectal adenocarcinoma patients. Clinical Chemistry and Laboratory Medicine [Internet]. 2017;55:737-747. Website
Diamantopoulos MA, Kontos CK, Kerimis D, Papadopoulos IN, Scorilas A. Upregulated miR-16 expression is an independent indicator of relapse and poor overall survival of colorectal adenocarcinoma patients. Clinical Chemistry and Laboratory Medicine. 2017;55:737-747.
Kellici TF, Ntountaniotis D, Vanioti M, Golic Grdadolnik S, Simcic M, Michas G, Moutevelis-Minakakis P, Mavromoustakos T. The use of J-coupling as a sole criterion to assign the total absolute stereochemistry of new pyrrolidinone class synthetic analogs, derived from S-pyroglutamic acid. Journal of Molecular Structure [Internet]. 2017;1129:195 - 199. Website
Patsantaras N, Kamberidou I. Virtual Bodies and Sport Activities: The case of the Avatars in Second Life Fitness Club. 13th Conference of the European Sociological Association “Un)Making Europe: Capitalism, Solidarities, Subjectivities” [Internet]. 2017;(European Sociological Association). Publisher's VersionAbstract
RN24_09a_P: Science, Technology, Innovation & Society II (Time: 01/Sep/2017: 11:00am-12:30pm) ABSTRACT:  Virtual environments (VE) are virtual social spaces that provide powerful means for creating, activating and modifying virtual bodies—Avatars—without dependencies on biological factors,formal rules and explicit conventions. VE offer unlimited possibilities to create the desired body and express personal bodily preference in virtual sport spaces without restrictions regarding established roles and behavioural expectations. Such a VE is Second Life (SL) in which the user is represented by an Avatar. This study focuses on a virtual sport space: the Fitness Club of Second Life. It examines the rules and regulations of this virtual space along with the role of 26 Avatars as bodily representations, including their bodily behaviours-exercises-practices in the SL Fitness Club. The data for this study was selected through systematic observation of 26 Avatars (apx. 180 hours) during March, April and May 2015, followed by detailed descriptions of single phenomena. Regarding the structure of space and bodily behavior, the results indicate less differences between sport virtual spaces and sport physical spaces, the opposite of what we had originally assumed. According to the results, the Avatar Fitness Club appears to be a highly individualistic and narcissistic environment. Moreover, every user can perform his/her bodily activities in a rather liberating way, occasionally surpassing biological limitations. When the Avatars exercise they imitate the movements of the physical sport world, namely they mimic the physical body. Further studies are needed to show the influence of an Avatar’s performance-bodily exercises on the real user, the individual behind the computer screen. KEYWORDS: Avatars, Fitness Club, Second Life, bodily exercisesAlso see:https://www.conftool.pro/esa2017/index.php?page=browseSessions&print=head&form_session=1625
virtual_bodies-avatars_and_sport_activities.pdf
Arabatzis T. What’s in It for the Historian of Science? Reflections on the Value of Philosophy of Science for History of Science. International Studies in the Philosophy of Science [Internet]. 2017;31(1):69-82. Publisher's VersionAbstract
In this article, I explore the value of philosophy of science for history of science. I start by introducing a distinction between two ways of integrating history and philosophy of science: historical philosophy of science (HPS) and philosophical history of science (PHS). I then offer a critical discussion of Imre Lakatos’s project to bring philosophy of science to bear on historical interpretation. I point out certain flaws in Lakatos’s project, which I consider indicative of what went wrong with PHS in the past. Finally, I put forward my own attempt to bring out the historiographical potential of philosophy of science. Starting from Norwood Russell Hanson’s insight that historical studies of science involve metascientific concepts, I argue that philosophical reflection on those concepts can be (and, indeed, has been) historiographically fruitful. I focus on four issues (epistemic values, experimentation, scientific discovery and conceptual change) and discuss their significance and utility for historiographical practice.
Ziogas DC, Terpos E, Dimopoulos MA. When to recommend a second autograft in patients with relapsed myeloma?. Leukemia and Lymphoma [Internet]. 2017;58(4):781 - 787. WebsiteAbstract
In the current evolving landscape of myeloma therapies, no recommended salvage strategy exists for patients with relapsed multiple myeloma (MM) after initial successful autologous stem cell transplantation (ASCT) and therapeutic options extend from conventional chemotherapy and novel agents to second autologous and allogeneic transplants. In this article, we summarize the documented evidence about the utilization of second ASCT in patients with relapsed MM after a primary auto-graft and discuss the correct timing for such a salvage approach, the individual characteristics of patients who will benefit more, as well as the therapeutic role of second ASCT in the modern era of forthcoming anti-myeloma treatments. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
Ziogas DC, Terpos E, Dimopoulos MA. When to recommend a second autograft in patients with relapsed myeloma?. Leukemia and Lymphoma [Internet]. 2017;58(4):781 - 787. WebsiteAbstract
In the current evolving landscape of myeloma therapies, no recommended salvage strategy exists for patients with relapsed multiple myeloma (MM) after initial successful autologous stem cell transplantation (ASCT) and therapeutic options extend from conventional chemotherapy and novel agents to second autologous and allogeneic transplants. In this article, we summarize the documented evidence about the utilization of second ASCT in patients with relapsed MM after a primary auto-graft and discuss the correct timing for such a salvage approach, the individual characteristics of patients who will benefit more, as well as the therapeutic role of second ASCT in the modern era of forthcoming anti-myeloma treatments. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
Giovani C, Kamberidou I, Patsantaras N. ΑΝΑΖΗΤΩΝΤΑΣ ΤΟΥΣ ΠΑΡΑΓΟΝΤΕΣ ΠΟΥ ΣΥΜΒΑΛΛΟΥΝ ΣΤΗΝ ΕΚΔΗΛΩΣΗ ΤΟΥ ΦΑΙΝΟΜΕΝΟΥ ΤΟΥ ΕΚΦΟΒΙΣΜΟΥ ΣΤΟ ΜΑΘΗΜΑ ΤΗΣ ΦΥΣΙΚΗΣ ΑΓΩΓΗΣ (Bullying in physical education classes). Πρακτικά του 4ου Συνεδρίου Αθλητικής Επιστήμης «Η Φυσική Αγωγή και ο Αθλητισμός στο Σύγχρονο Κόσμο: Παιδεία - Κοινωνία – Πολιτισμός» σελ. 102. 2017;1(1):102.Abstract
 Ένα από τα σημαντικότερα ζητήματα που έχει να αντιμετωπίσει σήμερα η εκπαιδευτική κοινότητα είναι αυτό του εκφοβισμού (bullying). Ερευνητικά δεδομένα υπογραμμίζουν ότι το φαινόμενο του εκφοβισμού στο σχολικό περιβάλλον ανατροφοδοτείται με έναν περίπλοκο τρόπο και είναι άρρηκτα συνδεδεμένο με εξωσχολικούς παράγοντες όπως οι αλλαγές στη δομή της οικογένειας και στην ποιότητα των ενδο-οικογενειακών και διαπροσωπικών σχέσεων, η συνεχής και αυξανόμενη έκθεση των παιδιών στη βία τόσο αναφορικά με τα ΜΜΕ όσο και κατά την ενασχόλησή τους με συγκεκριμένα ηλεκτρονικά παιχνίδια κ.α. Από ένα μεγάλο αριθμό διερευνητικών προσεγγίσεων επισημαίνεται ότι η ποιότητα του σχολικού κλίματος, η σχολική συνοχή καθώς και ο άμεσα περιβάλλων χώρος του σχολείου παίζουν σημαντικό ρόλο στην εκδήλωση επιθετικών ενεργειών. Στον ελλαδικό χώρο, παρ’ όλο που έχουν πραγματοποιηθεί πολλές έρευνες για τον εκφοβισμό ως μορφή ενδοσχολικής βίας, δεν υπάρχουν ακόμα αρκετές μελέτες, που να διαπραγματεύονται και να διερευνούν το ζήτημα αυτό στις προοπτικές του μαθήματος της Φυσικής Αγωγής (ΦΑ). Η παρούσα μελέτη –ως επιμέρους προσπάθεια μιας εν εξελίξει εμπειρικής έρευνας— βασίζεται σε ανασκόπηση της σύγχρονης ερευνητικής βιβλιογραφίας και έχει σκοπό να αναδείξει και να επισημάνει τους σημαντικότερους  παράγοντες που συμβάλλουν στην εκδήλωση του εκφοβισμού στις προοπτικές του μαθήματος της ΦΑ στον ελληνικό χώρο. Σύμφωνα με τη διεθνή βιβλιογραφία το μάθημα ΦΑ συμβάλλει θετικά στην ομαλή κοινωνικοποίηση και ενσωμάτωση των μαθητών στο σχολείο. Στις προοπτικές αυτές επισημαίνεται ότι οι Καθηγητές/τριες Φυσικής Αγωγής διαδραματίζουν καθοριστικό ρόλο στη δημιουργία θετικού κλίματος εφαρμόζοντας στρατηγικές και προγράμματα διαχείρισης διαπροσωπικών σχέσεων και συγκρούσεων. Ωστόσο από την άλλη πλευρά όπως διαπιστώνεται από τις σχετικές με αυτό το ζήτημα έρευνες που πραγματοποιήθηκαν σε άλλες χώρες, οι αθλητικές ή παιγνιώδεις ομαδικές δραστηριότητες που κατ’ εξοχήν χρησιμοποιούνται ως εκπαιδευτικό εργαλείο στη ΦΑ, δημιουργούν ευκαιρίες για στοχοποίηση κάποιων μαθητών/τριών εξαιτίας, μεταξύ άλλων, κάποιων ατομικών χαρακτηριστικών (π.χ. σωματικό βάρος, σεξουαλικό προσανατολισμό, φύλο, μειωμένο επίπεδο κινητικών δεξιοτήτων)  τόσο από τους συμμαθητές/τριες όσο και από τον εκπαιδευτικό της ΦΑ. Η στοχοποίηση αυτής της μορφής αναδεικνύεται ως ένας καταλυτικός και ουσιαστικός παράγοντας εκδήλωσης εκφοβιστικών συμπεριφορών.  Όπως προκύπτει από τα διεθνή ερευνητικά δεδομένα η ΦΑ αποτελεί ένα μέσον –ανάλογα με τον τρόπο που το οργανώνουμε και το διαχειριζόμαστε— τόσο για την καλλιέργεια και εκδήλωση του φαινομένου του εκφοβισμού όσο και για την άμβλυνσή του.   Βιβλιογραφικές Πηγές Bejerot, S., J. Edgar & B.M. Humble, (2010), “Poor performance in physical education – a risk factor for bully victimization. A case–control study”. In Acta Pædiatrica, 100: 413–419 Hicky, C., H. (2008), “Physical education, sport and hyper-masculinity in schools”. In Sport, Education and Society, 13(2): 147-161 Kamberidou, I. (2012). New Realms of Agency: Promoting Peace Education and Gender Equity through Sport. In Sport Science and Physical Education, [Ed. Luminita Georgescu],  Encyclopedia of Life Support Systems, Eolss Publishers, Oxford ,UK. Developed under the Auspices of UNESCO Oliver, K.L. & M. Hamzeh (2010), “The boys won't let us play” fifth-grade mestizas challenge physical activity discourse at school”. In Research Quarterly for Exercise and Sport81(1): 38-51 
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αναλυτικές οδηγίες με τον τρόπο ψηφιακής υπογραφής. 2017.Abstract
Στην περίπτωση που ο χρήστης διαθέτει adobe acrobat ακολουθούν αναλυτικές οδηγίες με τον τρόπο ψηφιακής υπογραφής (digital sign) ενός pdf εγγράφου και συγκεκριμένα του εξαγόμενου pdf με την απογραφή του ΤΠΕ εξοπλισμού του σχολείου.
Μάζης Ιωάννης. Ἀπὸ τὸν Νikolas J. Spykman στὸν Alexandre Kojève: Τὸ ἄγνωστο ταξεῖδι στὴν ἀντίληψη τῆς ἀσφαλείας τῆς Δύσεως. Ἡμέρα Μνήμης τῶν 72 Χρόνων ἀπὸ τῆς λήξεως τοῦ Μεγάλου Πατριωτικοῦ Πολέμου. 2017.Abstract
Το παρόν κείμενο εξετάζει συγκριτικά τα απαιτήματα-συμπεράσματα της θεωρίας του N. J. Spyman (1943) με την απόρρητη έκθεση (1945) του καθηγητού της Σορβόννης Alexandre Kojève προς τον στρατηγό Charles André Joseph Marie de Gaulle, περί δημιουργίας της ΕΚΑΧ και μετάπειτα ΕΟΚ και ΕΕ, υπό το φως της δημιουργίας μιας "Λατινικής Αυτοκρατορίας" αποτελουμένης από την προεξάρχουσα εις αυτήν Γαλλία, την Ιταλία και την Ισπανία, με τις αποικίες τους, οι οποίες θα λειτουγούσαν ως ενδιάμεση ζώνη ασφαλείας μεταξύ της "Αγγλοσαξωνικής Αυτοκρατορίας" και τις Σλαβοορθοδόξου Σοβιετικής Αυτοκρατορίας.
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Μάζης Ιωάννης. Γεωπολιτικὴ ἀνάλυσις τῶν Ρωσσο-Ἀμερικανικῶν ἐνεργειακῶν ἀνταγωνισμῶν στὸ Ὑποσύστημα τῶν Βαλκανίων ἐντὸς τοῦ Μείζονος Μεσογειακοῦ Συστήματος. Foreign Affairs, Hellenic Edition. 2017;(48).Abstract
Στὸ Γεωπολιτικὸ Σύμπλοκο τῆς Μεσογείου παρατηρεῖται τοὺς τελευταίους μῆνες μιὰ ἔντονη, ὅσο καὶ ἐπικίνδυνη, κινητικότητα στὸ τμῆμα τῶν ∆υτικῶν Βαλκανίων ἐντὸς τοῦ γεωπολιτικοῦ Ὑποσυστήματος τῶν Βαλκανίων. Ἡ χώρα μας ἔχει τὸ θλιβερὸν προνόμιον νὰ ἀποτελεῖ τὴν τομὴν τῶν δύο ἀσταθῶν Ὑποσυστημάτων τοῦ Μεσογειακοῦ Γεωπολιτικοῦ Συμπλόκου: α) τοῦ Ὑποσυστήματος τῶν Βαλκανίων καὶ β) τοῦ Ὑποσυστήματος Τουρκίας-Ἐγγύς Ἀνατολῆς. Θὰ ἀποδείξομε ἀφ' ἐνὸς ὅτι τὰ δύο αὐτὰ Ὑποσυστήματα εὑρίσκονται σὲ ἔντονη ὅσο καὶ ἀσταθῆ συλλειτουργία στὴν παροῦσα συγκυρία, καὶ ἀφ' ἑτέρου θὰ ἀναδειχθεῖ ὁ κύριος γεωπολιτικὸς παράγων, γενεσιουργὸς τῆς ἀσταθείας αὐτῆς, ὁ ὁποῖος εἶναι ἡ Ἐνεργειακὴ Ἀσφάλεια. Ἐπίσης θὰ καταδειχθοῦν οἱ βασικοὶ πόλοι διεθνοῦς ἰσχύος, ἡ Μόσχα καὶ ἡ Οὐάσιγκτων, ὁ νεοψυχροπολεμικοῦ τύπου ἀνταγωνισμὸς τῶν ὁποίων θέτει σὲ ἀποσταθεροποιητικὴ δυναμικὴ τὸ Γεωπολιτικὸ σύμπλοκο τῆς Μεσογείου μὲ κύρια ἑστία τὰ ∆υτικὰ Βαλκάνια. Ὁ ὅρος "νεοψυχροπολεμικοῦ τύπου" χρησιμοποιεῖται γιὰ νὰ τονισθεῖ τὸ γεγονὸς ὅτι ὑπάρχει σημαντικὴ ἰδεολογικὴ ἀπόστασις μεταξὺ τῶν δύο αὐτῶν πόλων (καὶ φυσικὰ —ἀλλὰ περισσότερον συγκεκαλυμμένος— μεταξὺ Οὐάσιγκτων καὶ Πεκίνου), ὅπως κατὰ τὴν περίοδον τοῦ Ψυχροῦ Πολέμου. Ἡ ἰδεολογικὴ διαφορὰ στὴν περίπτωση αὐτὴν ἔγκειται στὴν δυτικὴ κοσμοπολιτικὴ καὶ ἀκραίως νεοφιλελεύθερη δυτικὴ προσέγγιση καὶ τὴν ἐθνο-ταὐτοτικὴ συντηρητικὴ προσέγγιση τῆς Ἀνατολῆς, μὲ προεξάρχοντα πόλο τὴν Μόσχα. Τὸ θεωρητικὸ ὑπόβαθρο τῆς παρούσης ἀναλύσεως εἶναι αὐτὸ τῆς κλασικῆς ἀγγλοσαξωνικῆς γεωπολιτικῆς σχολῆς μὲ ὑπόδειγμα αὐτὸ τοῦ Ν. J. Spykman ὅπως ἐξελίχθηκε ἀπὸ τὶς προσεγγίσεις τοῦ Ζ. Brzezinsky καὶ ἡ μεθοδολογικὴ προσέγγισις αὐτὴ τῆς Συγχρόνου Συστημικῆς Γεωπολιτικῆς Ἀναλύσεως.
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Drikos S, Kountouris P, Somponis G. ΔΙΑΧΡΟΝΙΚΗ ΜΕΛΕΤΗ ΣΥΜΒΟΛΗΣ ΤΩΝ ΤΕΧΝΙΚΩΝ ΔΕΞΙΟΤΗΤΩΝ ΣΤΗΝ ΑΓΩΝΙΣΤΙΚΗ ΕΠΙΤΥΧΙΑ ΤΗΣ ΠΕΤΟΣΦΑΙΡΙΣΗΣ ΑΝΔΡΩΝ. In: 4o Συνέδριο Αθλητικής Επιστήμης, «Η Φυσική Αγωγή και ο Αθλητισμός στο σύγχρονο κόσμο: Παιδεία – Κοινωνία - Πολιτισμός». ΣΕΦΑΑ Αθήνας, 4-7 Μαΐου 2017, Αθήνα. http://sefaacongress.phed.uoa.gr/: School of Physical Education & Sport Science ATHENS; 2017. pp. 77-78. Publisher's VersionAbstract
Εισαγωγή:. Στηv Πετοσφαίριση η αγωνιστική απόδοση εξαρτάται από την επίδοση των αθλητών στις τεχνικές δεξιότητες του παιχνιδιού (Marcelino, Mesquita, & Alfonso, 2008) και η αθλητική επιτυχία μπορεί να ποσοτικοποιηθεί με βάση την αγωνιστική απόδοση (Lobietti, Michele, & Merni, 2006). Με τη χρήση δεδομένων από μία αγωνιστική περίοδο, βρέθηκε υψηλή συσχέτιση μεταξύ της αγωνιστικής επιτυχίας (σύνολο πόντων σε πρωτάθλημα), με το άθροισμα των δεικτών αποτελεσματικότητας σερβίς και επίθεσης (Drikos, Kountouris, Laios, & Laios, 2009). Η παρούσα μελέτη εξετάζει την αγωνιστική επιτυχία (τελική κατάταξη στην 1η τετράδα της κανονικής περιόδου) σε σχέση με την αγωνιστική απόδοση, στη διάρκεια 11 συνεχών αγωνιστικών περιόδων του πρωταθλήματος Πετοσφαίρισης Ανδρών Ελλάδος. Μέθοδος:. Τα δεδομένα προήλθαν από την καταγραφή της αγωνιστικής απόδοσης των ομάδων (Ν=131), που συμμετείχαν στις κανονικές αγωνιστικές περιόδους (2005- 6 έως 2015-16) των πρωταθλημάτων Α1 κατηγορίας Ανδρών, σε τέσσερις βασικές τεχνικές δεξιότητες του παιχνιδιού (επίθεση, σερβίς, υποδοχή σερβίς και μπλοκ). Η αξιολόγηση της εκτέλεσης των τεχνικών δεξιοτήτων πραγματοποιήθηκε με τακτική κλίμακα 6 επιπέδων. Η αξιοπιστία μεταξύ των βαθμολογητών ελέγχθηκε με σταθμισμένο δείκτη Κ Cohen και ήταν Adjusted Κ= .85, πολύ καλή (Altman, 1991). Η στατιστική επεξεργασία των δεδομένων έγινε μέσω πολυμεταβλητής ανάλυσης διακύμανσης και διακριτής ανάλυσης, για τον προσδιορισμό των διαφορών ανάμεσα στις ομάδες των θέσεων 1-4, 5-8 και 9-12 και των δεξιοτήτων που κατατάσσουν με επιτυχία τις παρατηρήσεις. Αποτελέσματα:. Υπήρξε στατιστικά σημαντική διαφορά των μέσων όρων στις ομάδες 1-4 σε σχέση με τις υπόλοιπες, σε όλες τις τεχνικές δεξιότητες, εκτός από την υποδοχή σερβίς και στις ομάδες 5-8 με τις αντίστοιχες 9-12 στην επίθεση μετά από υποδοχή σερβίς και στo μπλοκ. Οι μεταβλητές με συντελεστή συσχέτισης >|.3| με τη διαχωριστική συνάρτηση, ήταν οι δείκτες αποτελεσματικότητας σερβίς (-.42), επίθεσης μετά από υποδοχή σερβίς (.90), επίθεσης μετά από άμυνα (.60) Η διαχωριστική συνάρτηση κατέταξε με επιτυχία για το σύνολο του δείγματος το 72% των παρατηρήσεων Για τις θέσεις 1-4 η επιτυχημένη κατάταξη ήταν 87,5%, ενώ για τα γκρουπ 5-8 και 9-12 ήταν 65% αντίστοιχα.Συμπεράσματα: Οι ομάδες των θέσεων 1-4 αποδίδουν καλύτερα σε όλες τις δεξιότητες που κατακτούν πόντο. Η αγωνιστική επιτυχία μπορεί να ερμηνευθεί με τη χρήση των δεικτών αποτελεσματικότητας, λόγω της καλής προσαρμογής του μοντέλου.
Georgiou Y, Patsantaras N, Kamberidou I. Διευρευνώντας τις σχέσεις μεταξύ δρομικού κινήματος και τυπικά οργανωμένων αθλητικών θεσμών στην Ελληνική επικράτεια. Βιβλίο Πρακτικών (σελ. 97-98, 1η έκδοση) του 4ου Συνεδρίου Αθλητικής Επιστήμης «Η Φυσική Αγωγή και ο Αθλητισμός στο Σύγχρονο Κόσμο: Παιδεία - Κοινωνία- Πολιτισμός. 2017;(1):97-98. running_movememt._authentic_marathon.pdf conference_proceedings._praktika_synedrioy_1st_edition_may_2017.pdf
Εκπαίδευση και εκπαιδευτική μεταρρύθμιση: ιστορικο-συγκριτικές προσεγγίσεις. 1st ed. (Δημήτρης Φωτεινός, κ.α.). Athens, Greece: Gutenberg; 2017.
Μάζης Ιωάννης, Δωματιώτη Ξανθίππη, Δήγκας Άγης. Ἐφαρμογὴ Ἀπλῶν καὶ Σύνθετων Δεικτῶν τῶν Τεσσάρων Γεωπολιτικῶν Πυλώνων στὴν Μεθοδολογία τῆς Συστημικῆς Γεωπολιτικῆς Αναλύσεως: Ἡ Περίπτωση τῆς Συρίας. Civitas Gentium. 2017;5(2).Abstract
Η παρούσα επιστημονική δημοσίευση, αποτελεί εφαρμογή απλών και σύνθετων γεωπολιτικών δεικτών, των τεσσάρων γεωπολιτικών πυλώνων στη μεθοδολογία της συστημικής γεωπολιτικής αναλύσεως. Ως περίπτωση εξετάζεται η Συριακή Κρίση.
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Μάζης Ιωάννης. Ἡ Ἀρμενικὴ γενοκτονία ὡς ἀποτελέσμα τῶν γεωστρατηγικῶν ἀνταγωνισμῶν τῶν μεγάλων δυνάμεων στὴν Εὐρύτερη Μέση Ἀνατολὴ. In: Ἡμέρα Μνήμης τῆς Ἀρμενικῆς Γενοκτονίας, 22 Ἀπριλίου 2017, Ἑταιρεία Μακεδονικῶν Σπουδῶν. Θεσσαλονίκη; 2017.Abstract
Ἡ κατάστασις σήμερα πιέζει γιὰ τὴ δημιουργίαν-πλησίον τῆς ἰσχυρᾶς καὶ εὐημερούσης οἰκονομικῶς Ἀρμενίας-καὶ ἑνὸς ἀνεξαρτήτου πλέον Κουρδιστάν. Τὸ νέο αὐτὸ κράτος λειτουργῶντας ὡς «buffer state/état tampon» μεταξὺ Ἀράβων, Ἰρανῶν, Σύρων καὶ Ἰρακινῶν καὶ ἐν συνδυασμῷ πρὸς μιὰ ἀπαραιτήτως ἰσχυρὰν Ἀρμενία καὶ τὸ ἤδη ἰσχυρὸ καὶ σταθερὸ ὡς πρὸς τὶς διεθνεῖς του σχέσεις Ἰσραήλ, μποροῦν νὰ ἐγγυηθοῦν τὸ ἀπαραίτητο καθεστὼς ἀσφαλείας στὴν Κεντρικὴ Ἀσία. Ἡ Ρωσσία τοῦ Ποῦτιν, ἡ ἀμερικὴ τῶν Ὀμπάμα καὶ Τρὰμπ ἀλλὰ καὶ τὸ Ἰσραὴλ τοῦ Νετανιάχου ἐπιθυμοῦν διακαῶς μιὰν ἀνάλογη λύση. Ἡ  καθεμία πλευρὰ γιὰ τοὺς δικούς της γεωστρατηγικοὺς λόγους. Ἡ Ρωσσία γιὰ νὰ ἀπομακρύνει τὸν ἰσλαμιστικὸν κίνδυνο ἀπὸ τὰ ἐδάφη τοῦ «ἐγγὺς ἐξωτερικοῦ»της στὴν Κεντρικὴ Ἀσία. Οἱ ΗΠΑ γιὰ νὰ ἀποκτήσουν ἕνα φερέγγυο σύμμαχο καὶ προβολέα ἰσχύος στὴν Μέση Ἀνατολή, στὸν Ἀραβοπερσικὸ Κόλπο καὶ τὸ κέντρο τοῦ ∆ρόμου τοῦ Μεταξιοῦ. Τὸ Ἰσραὴλ γιὰ νὰ ἀποκτήσει χερσαῖο στρατηγικὸ βάθος σὲ ἕνα ἐπισφαλὲς ἰρανο-ἀραβικὸ ἰσλαμιστικὸ περιβάλλον. Ἡ ἐγκατάλειψις τῆς εἰρήνης στὰ χέρια μιᾶς παντουρκιστικῆς τουρκικῆς πολιτικῆς, ἀπὸ πλευρᾶς ∆ύσεως, θὰ σημάνει τὴν ἔναρξη μιᾶς σειρᾶς ἁλυσιδωτῶν ἐκρήξεων μεταξὺ τῶν ἀλλοϋποβλεπομένων δρώντων στὴν περιοχή, ὅπως τὸ Ἰράν, τὸ Πακιστάν, ἡ Ρωσσία, ἡ Σ. Ἀραβία, ἡ Αἴγυπτος καὶ τὸ ἀπολύτως ἀσταθὲς Ἀφγανιστάν. Τὰ ἀποτελέσματα θὰ εἶναι δεινὰ γιὰ τὴν εἰρήνη καὶ τὸν δυτικὸ πολιτικὸ πολιτισμὸ εἰς τὴν γεωπολιτικὴν αὐτὴν ζώνη. Καὶ αὐτὸ διότι ὁ προϊὼν ἰσλαμιστικὸς χαρακτὴρ τῆς Ἀγκύρας ὁ ὁποῖος ἔχει ἐνταχθεῖ στὸ εὐρύτερο ριζοσπατικὸ ἰσλαμιστικὸ ὄχημα τῆς «διεθνοῦς» τῶν Ἀδελφῶν Μουσουλμάνων9, σίγουρα θὰ προωθήσει τὴν ἐξαγωγὴ τῆς «ἰσλαμικῆς ἐπαναστάσεως» καὶ τῶν ἱεροπολεμικῶν ἀντιλήψεων καὶ στὴν ζώνη τῶν Βαλκανίων. Στὴν φάση ὅμως αὐτὴν ἡ Τουρκία δὲν θὰ κατωρθώσει νὰ πείσει οὔτε κἂν τὸν ἑαυτόν της εἰς ὅ,τι ἀφορᾷ τὶς δημοκρατικές της πεποιθήσεις, καὶ ὁ Χάρτης τῆς Εὐρυτέρας Μέσης Ἀνατολῆς ἀναδιατάσσεται ἔχοντας αὐτὸ ὡς δεδομένο. Ἴσως τώρα ἦλθε ἡ ὥρα νὰ ἀντιληφθοῦν οἱ «μαθητευόμενοι μάγοι» τῶν διεθνῶν μητροπολιτικῶν ἐπιτελείων τὰ μέχρι σήμερα λάθη τους. Ἐλπίζομε ὅμως νὰ μὴ εἶναι εἶναι ἀργὰ καὶ γι' αὐτούς, ἀλλὰ κυρίως γιὰ ὁλόκληρη τὴν ἀνθρωπότητα. Ὁ συστηματικὸς διωγμὸς τῶν χριστιανικῶν πληθυσμῶν στὴν Μέση Ἀνατολὴ ἀπὸ τὶς ριζοσπαστικὲς ἰσλαμιστικὲς τάσεις καὶ ὀργανώσεις, οἱ ὁποῖες ἐξετράφησαν καὶ ἐξωπλίσθησαν ἀπὸ τὴν ∆ύση καὶ τοὺς συμμάχους τους στὴν Μέση Ἀνατολὴ ἐπιδεικνύουν τὴν κατεύθυνση πρὸς τὴν κεντρικὴ Ἀσία τῶν ἰσλαμιστικῶν βλέψεών τους. Ἀνάχωμα σὲ αὐτὲς τὶς βλέψεις στὸν Καύκασο καὶ τὴν περιοχὴ τῆς Κασπίας καὶ τοῦ Εὐξείνου Πόντου ἀποτελεῖ ἡ Ἀρμενία. Ἂν ἡ Ἀρμενία ὑποχωρήσει, τὰ Βαλκάνια εἶναι μιὰ χαμένη ὑπόθεσις γιὰ τὴν ∆ύση καὶ ἕνα νέο Ἐμιρᾶτο γιὰ τὸ ριζοσπαστικὸ Ἰσλὰμ τοῦ ΙSIS καὶ τῶν παρακλαδιῶν τῆς ἀλ Κάϊντα καὶ τῶν Ἀδελφῶν Μουσουλμάνων.
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Kefi Chatzichamperi E, Kamberidou I, Patsantaras N. Η Φυσική Αγωγή και η Άθληση ως Παράγοντας Ενσωμάτωσης του Γυναικείου Φύλου στις Ανώτατες Στρατιωτικές Σχολές στην Ελλάδα (Gender and the Military in Gre. Πρακτικά του 4ου Συνεδρίου Αθλητικής Επιστήμης «Η Φυσική Αγωγή και ο Αθλητισμός στο Σύγχρονο Κόσμο: Παιδεία - Κοινωνία – Πολιτισμός», σελ. 96-97. 2017;1(1):96-97. 1._gender_and_the_military_by_chatzichamperi_kamberidou_patsantaras.pdf conference_proceedings._praktika_synedrioy_1st_edition_may_2017.pdf
Μάζης Ιωάννης. Ἡ Χρῆσις τῆς Γνώσεως στὶς γεωπολιτικὲς ἐπιδιώξεις τῶν κρατούντων τῆς γῆς. Ἀριστοτέλειον Πανεπιστήμιον Θεσσαλονίκης Ἐπιτροπὴ Κοινωνικῆς Πολιτικῆς καὶ ὑγιείας. 2017.Abstract
Ἡ γνῶσις τῆς γεωπολιτικῆς πραγματικότητος ἀπετέλεσε, ἀποτελεῖ καὶ θὰ ἀποτελεῖ πάντοτε πρόκληση πρὸς τοὺς πολιτικοὺς καὶ πνευματικοὺς ταγούς. Οἱ κρατοῦντες εἰς τὸν Πλανήτη διαθέτουν ἰσχυρὰ κέντρα μελέτης τῆς γεωπολιτικῆς πραγματικότητος, ὥστε λαμβάνοντες ὑπ' ὄψιν τὰ προκύπτοντα γεωπολιτικὰ ὑποδείγματα νὰ προβοῦν στὴν χάραξη τῶν ἀντιστοίχων ἡγεμονικῶν ἢ κυριαρχικῶν διεθνῶν στρατηγικῶν τους. Το παρόν κείμενο αναφέρεται στη χρήση της γνώσεως στις γεωπολιτικές επιδιώξεις των κρατούντων της γης.
1._xvi.pdf
Φωτεινός Δημήτρης. Ιστορία της εκπαίδευσης. Μια προσέγγιση στη γενεαλογία του θεσμού. 1st ed. Athens, Greece: Γρηγόρης; 2017 pp. 335. Publisher's VersionAbstract
Με το εγχείρημά μας αυτό προσπαθήσαμε να δώσουμε μια γενεαλογική διάσταση στην αφήγηση της ιστορίας της εκπαίδευσης. Αναφερθήκαμε σε δομικά ζητήματα (οικονομικοί και κοινωνικοί μετασχηματισμοί), σε θεσμικές ρυθμίσεις (κατασκευή της εκπαίδευσης μέσα από την απόσχισή της από άλλο προϋπάρχοντα θεσμό), σε πολιτικά προβλήματα, σε ιδέες που διαμορφώθηκαν από συγκεκριμένους διανοούμενους, σε συγκεκριμένες συνθήκες (είτε προσωπικές, είτε ευρύτερες). Προφανώς, η ιστορία δεν είναι πλήρης, με την έννοια ότι δεν αναφερθήκαμε σε «όλα» όσα συνέβησαν, δεν αναφέραμε όλους όσοι ενεπλέκησαν, δεν επιμείναμε σε κάθε λεπτομέρεια. Αυτό είναι ούτως ή άλλως αδύνατο. Η ιστορική αφήγηση είναι ένα νοηματικό σχήμα που καλύπτει υπό μία θεώρηση το παρελθόν. Είναι αδύνατο να γράψει κανείς για «όλα» όσα συνέβησαν: αν το κάνει θα είναι μια απλή γεγονοτογραφία. Αν επιχειρήσει να ερμηνεύσει, τότε αναγκαστικά θα περιοριστεί σε κάποια από τα συμβάντα (θα τα αναδείξει, δηλαδή, ως ιστορικά τεκμήρια). Άρα, εκ των πραγμάτων, δεν χρειάζεται να αναφερθεί σε «όλα». Αυτό που μπορούμε να δούμε ως ένα πρώτο συμπέρασμα μέσα από αυτό το αφήγημα της εκπαίδευσης είναι ότι η ανάγκη του ανθρώπου για να προσδιοριστεί είναι σημαντική, και αυτό προσπάθησε να κάνει στο διάβα της ιστορίας. Η εκπαίδευση φαίνεται να δίνει εκείνα τα στοιχεία της ταυτότητάς μας, με τα οποία αναγνωρίζουμε τον εαυτό μας, τους άλλους, το πλαίσιο στο οποίο κινούμαστε. Αυτή η ταυτότητα, ωστόσο, είναι, όπως διαμορφώνεται μέσα από την εκπαίδευση, μια επιβαλλόμενη ταυτότητα: εμπεριέχει προγενέστερες ρυθμίσεις, ρυθμίσεις άλλων σύγχρονών μας. Εμπεριέχει, όμως, και τις δικές μας προθέσεις, προτιμήσεις, ανάγκες, διαθέσεις. Εν κατακλείδι, θα μπορούσαμε να πούμε ότι η εκπαίδευση είναι ο χώρος όπου διαμορφώνεται διαλεκτικά (άρα και συγκρουσιακά) η ταυτότητά μας: είναι ένα διαρκές «γίγνεσθαι», στο οποίο συμμετέχουμε. Όσο πιο πολύ συμμετέχουμε, τόσο περισσότερο ολοκληρώνεται, εμπλουτίζεται, εμβαθύνεται η ταυτότητά μας. Συνεπώς, η εκπαίδευση είναι το ιδανικό πεδίο στο οποίο μπορεί να βρει έκφραση η «πράξη» (praxis), η πολιτική πράξη της διαπραγμάτευσης με τη γνώση.
Karella M, Kamberidou I, Papakostas C. Ο Οικονομικός Χαρακτήρας των Πανηγυριών: Επιτόπια Έρευνα στη Βάρη Αττικής. Ανακοίνωση στα Πρακτικά του 4ου Συνεδρίου Αθλητικής Επιστήμης «Η Φυσική Αγωγή και ο Αθλητισμός στο Σύγχρονο Κόσμο: Παιδεία - Κοινωνία – Πολ. 2017;1(Πρώτη έκδοση):92-93. conference_proceedings._praktika_synedrioy_1st_edition_may_2017.pdf
Κουμαριανός Θεόδωρος Ι. «Οι χοροι τών αγίων». In: ΙΣΤ΄ Πανελλήνιο Λειτουργικό Συμπόσιο Στελεχών Ιερών Mητροπόλεων, Λαμια, Σεπτέμβριος 2016. «Το Αγιολόγιον τής Εκκλησίας». Αποστολικὴ Διακονία τής Εκκλησίας τής Ελλάδος, Αθήναι; 2017. pp. 83-116.
Spenga A, Kamberidou I, Patsantaras N. Παράγοντες που επηρεάζουν τη συμμετοχή των μαθητριών Γυμνασίου και Λυκείου στο μάθημα της Φυσικής Αγωγής / Factors that influence female high school and junior high. Ανακοίνωση στα πρακτικά του 4ου Συνεδρίου Αθλητικής Επιστήμης «Η Φυσική Αγωγή και ο Αθλητισμός στο Σύγχρονο Κόσμο: Παιδεία - Κοινωνία – Πολ. 2017;1(1):99.Abstract
Σπέγγα, Α.,  Καμπερίδου,  Ει.,  & Πατσαντάρας, Ν. (2017).  "Παράγοντες που επηρεάζουν τη συμμετοχή των μαθητριών Γυμνασίου και Λυκείου στο μάθημα της Φυσικής Αγωγής / Factors that influence female high school and junior high school students’ participation in physical education classes". Ανακοίνωση στα πρακτικά του 4ου Συνεδρίου Αθλητικής Επιστήμης «Η Φυσική Αγωγή και ο Αθλητισμός στο Σύγχρονο Κόσμο: Παιδεία - Κοινωνία – Πολιτισμός», σελ. 99. Σχολή Επιστήμης Φυσικής Αγωγής και Αθλητισμού (ΣΕΦΑΑ), Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ).  
factors_that_influence_female_participation_spenga_kamberidou_patsantaras.pdf conference_proceedings._praktika_synedrioy_1st_edition_may_2017.pdf
Georgiou Y, Patsantaras N, Kamberidou I. ΣΤΑΣΕΙΣ ΤΩΝ ΦΟΙΤΗΤΩΝ/ΤΡΙΩΝ ΤΗΣ ΣΕΦΑΑ ΑΠΕΝΑΝΤΙ ΣΤΗΝ ΑΝΔΡΙΚΗ ΚΑΙ ΓΥΝΑΙΚΕΙΑ ΟΜΟΦΥΛΟΦΙΛΙΑ (Student Attitudes concerning Homosexuality, 2nd edition). Δεύτερη Έκδοση, Βιβλίο Πρακτικών του 4ου Συνεδρίου Αθλητικής Επιστήμης «Η Φυσική Αγωγή και ο Αθλητισμός στο Σύγχρονο Κόσμο: Παιδεία - Κοινωνία-Πολιτισμός. 2017;(2):92-93. student_attitudes_on_homosexuality.pdf
Kamberidou I. Το Ανεκμετάλλευτο Κοινωνικό Κεφάλαιο του Αθλητισμού: Η Γυναίκα Αθλήτρια (Δεύτερη Έκδοση), σελ. 33-37. Δεύτερη Έκδοση Βιβλίο Πρακτικών του 4ου Συνεδρίου Αθλητικής Επιστήμης «Η Φυσική Αγωγή και ο Αθλητισμός στο Σύγχρονο Κόσμο: Παιδεία - Κοινων. 2017;(2):33-37.Abstract
Καμπερίδου, Ειρήνη (2017). Το Ανεκμετάλλευτο Κοινωνικό Κεφάλαιο του Αθλητισμού: Η Γυναίκα Αθλήτρια. Δεύτερη Έκδοση Βιβλίο Πρακτικών του 4ου Συνεδρίου Αθλητικής Επιστήμης «Η Φυσική Αγωγή και ο Αθλητισμός στο Σύγχρονο Κόσμο: Παιδεία - Κοινωνία – Πολιτισμός», σελ. 33-37. Σχολή Επιστήμης Φυσικής Αγωγής & Αθλητισμού του Εθνικού και Καποδιστριακού Πανεπιστημίου Αθηνών (ΕΚΠΑ).............................................................:  ΠΕΡΙΛΗΨΗ -- ABSTRACT Οι έρευνες της έμφυλης διάστασης του κοινωνικού κεφαλαίου, μολονότι περιορισμένες, δείχνουν  ότι οι γυναίκες παίζουν σημαντικό ρόλο στην ανάπτυξη και αναπαραγωγή του, αναλαμβάνοντας κυρίως εθελοντικές δράσεις κοινωνικής προσφοράς και δράσεις κοινωνικής επιχειρηματικότητας που συντελούν καταλυτικά στην κοινωνική και οικονομική ευημερία. Επιπρόσθετα τα αποτελέσματα μεγάλου αριθμού ποιοτικών ερευνών, οι οποίες επικεντρώνουν το ενδιαφέρον τους στις αλληλεπιδράσεις μεταξύ  φύλου, αθλητισμού και επιχειρηματικότητας, δείχνουν μια θετική συσχέτιση μεταξύ των παραμέτρων αθλητική εμπειρία και επιτυχημένη ηγεσία. Η διερευνητική αυτή προσπάθεια  προσεγγίζει τον αθλητισμό στις προοπτικές της θεώρησης περί κοινωνικού κεφαλαίου. Βασιζόμενη σε μια ενδελεχή ανασκόπηση της διεθνούς σχετικής βιβλιογραφίας, και στα αποτελέσματα ποιοτικής έρευνας (8 ημι-δομημένες συνεντεύξεις) που διενεργήθηκε το 2016-2017, στοχεύει να εξηγήσει το ζήτημα της υποεκπροσώπησης των γυναικών όσον αφορά στις θέσεις διοικητικής ευθύνης στους αθλητικούς θεσμούς και κυρίως να αναδείξει τα εμπόδια που λειτουργούν καταλυτικά για την εμφάνιση αυτής της υποεκπροσώπησης.  Επικεντρώνει το ενδιαφέρον της στη γυναικεία συμμετοχή, που κατά κανόνα παραμένει μια  ανεκμετάλλευτη πηγή κοινωνικής ενέργειας και η οποία υπό συνθήκες μπορεί να διευκολύνει ποικίλες διαδικασίες κοινωνικής ενσωμάτωσης.  Επίσης διερευνά πιθανούς συσχετισμούς μεταξύ αθλητικής εμπειρίας και επιχειρηματικής δραστηριότητας. Υποκείμενα της έρευνας ήταν οκτώ εν ενεργεία και πρώην Ελληνίδες αθλήτριες, πρωταθλήτριες, ολυμπιονίκες και ακτιβίστριες—που έχουν διαπρέψει στην αθλητική ηγεσία και στο αθλητικό επιχειρείν. Τα αποτελέσματα δείχνουν ότι ο αθλητισμός προάγει δεξιότητες που είναι σημαντικές για την επιχειρηματικότητα και την ανάληψη δραστηριοτήτων διοικητικής μέριμνας και ευθύνης.  Ωστόσο οι γυναίκες που ενεργοποιούνται στο χώρο του αθλητισμού και επιδιώκουν να αναρριχηθούν σε θέσεις διοικητικής ευθύνης ή να ασκήσουν επιχειρηματικότητα στον χώρο αυτό, έχουν να υπερβούν πολλά εμπόδια. Μεταξύ άλλων επισημαίνονται: (1) οι προκαταλήψεις και τα στερεότυπα που ακόμα είναι κυρίαρχα και προκύπτουν από τις ανδροκεντρικές καταβολές του αθλητισμού, (2) η έλλειψη γυναικών μεντόρων, (3) η  έλλειψη γυναικών προτύπων, (4) οι άνισες ευκαιρίες εξέλιξης στην αθλητική ηγεσία σε σύγκριση με τους άνδρες, (5) η  έλλειψη ισορροπίας μεταξύ επαγγελματικής και ιδιωτικής/οικογενειακής ζωής. Απάντηση σε αυτή την υποεκπροσώπηση αποτελούν προγράμματα που προωθούν, προβάλλουν, και δημιουργούν γυναίκες μέντορες και κοινωνικά πρότυπα όπως εκείνο της Ελληνικής Ολυμπιακής Επιτροπής (ΕΟΕ) και του Συλλόγου Ελλήνων Ολυμπιονικών (ΣΕΟ) «Κάνουμε Χώρο για περισσότερες γυναίκες στην Αθλητική Συμμετοχή, την Προπονητική  Καθοδήγηση, και ειδικά τη Διοικητική Στελέχωση». Λέξεις κλειδιά: κοινωνική ενσωμάτωση, φύλο, αθλητισμός, ηγεσία, επιχειρηματικότητα, «έμφυλη κόπωση» (gender fatigue), «σπατάλη εσωτερικού ταλέντου» (wastage of internal talent),  «καμπύλη  ηλιθιότητας» (Stupid Curve), εξισορρόπηση επαγγελματικής και ιδιωτικής ζωής, γεφυρώνοντας το έμφυλο χάσμα     -Βλ. ολόκληρο το άρθρο / full pdf at http://www.tinyurl.com/k69yg56   στις σελίδες  31-40. -UoA scholar:  Το Ανεκμετάλλευτο Κοινωνικό Κεφάλαιο του Αθλητισμού: Η Γυναίκα Αθλήτρια , και στο -RG: https://www.researchgate.net/publication/316990102_To_Anekmetalleuto_Koinoniko_Kephalaio_tou_Athletismou_E_Gynaika_Athletria  
second_edition.defteri_ekdosipraktika_synedrioy_2i_ekdosi.pdf deltio_typoy.pdf
Καμπερίδου Ειρήνη. Το Ανεκμετάλλευτο Κοινωνικό Κεφάλαιο του Αθλητισμού: Η Γυναίκα Αθλήτρια. Πρακτικά του 4ου Συνεδρίου Αθλητικής Επιστήμης «Η Φυσική Αγωγή και ο Αθλητισμός στο Σύγχρονο Κόσμο: Παιδεία - Κοινωνία – Πολιτισμός», σελ. 31-40. 2017;1(1):31-40.Abstract
Οι έρευνες της έμφυλης διάστασης του κοινωνικού κεφαλαίου, μολονότι περιορισμένες, δείχνουν  ότι οι γυναίκες παίζουν σημαντικό ρόλο στην ανάπτυξη και αναπαραγωγή του, αναλαμβάνοντας κυρίως εθελοντικές δράσεις κοινωνικής προσφοράς και δράσεις κοινωνικής επιχειρηματικότητας που συντελούν καταλυτικά στην κοινωνική και οικονομική ευημερία. Επιπρόσθετα τα αποτελέσματα μεγάλου αριθμού ποιοτικών ερευνών, οι οποίες επικεντρώνουν το ενδιαφέρον τους στις αλληλεπιδράσεις μεταξύ  φύλου, αθλητισμού και επιχειρηματικότητας, δείχνουν μια θετική συσχέτιση μεταξύ των παραμέτρων αθλητική εμπειρία και επιτυχημένη ηγεσία. Η διερευνητική αυτή προσπάθεια  προσεγγίζει τον αθλητισμό στις προοπτικές της θεώρησης περί κοινωνικού κεφαλαίου. Βασιζόμενη σε μια ενδελεχή ανασκόπηση της διεθνούς σχετικής βιβλιογραφίας, και στα αποτελέσματα ποιοτικής έρευνας (8 ημι-δομημένες συνεντεύξεις) που διενεργήθηκε το 2016-2017, στοχεύει να εξηγήσει το ζήτημα της υποεκπροσώπησης των γυναικών όσον αφορά στις θέσεις διοικητικής ευθύνης στους αθλητικούς θεσμούς και κυρίως να αναδείξει τα εμπόδια που λειτουργούν καταλυτικά για την εμφάνιση αυτής της υποεκπροσώπησης.  Επικεντρώνει το ενδιαφέρον της στη γυναικεία συμμετοχή, που κατά κανόνα παραμένει μια  ανεκμετάλλευτη πηγή κοινωνικής ενέργειας και η οποία υπό συνθήκες μπορεί να διευκολύνει ποικίλες διαδικασίες κοινωνικής ενσωμάτωσης.  Επίσης διερευνά πιθανούς συσχετισμούς μεταξύ αθλητικής εμπειρίας και επιχειρηματικής δραστηριότητας. Υποκείμενα της έρευνας ήταν οκτώ εν ενεργεία και πρώην Ελληνίδες αθλήτριες, πρωταθλήτριες, ολυμπιονίκες και ακτιβίστριες—που έχουν διαπρέψει στην αθλητική ηγεσία και στο αθλητικό επιχειρείν. Τα αποτελέσματα δείχνουν ότι ο αθλητισμός προάγει δεξιότητες που είναι σημαντικές για την επιχειρηματικότητα και την ανάληψη δραστηριοτήτων διοικητικής μέριμνας και ευθύνης.  Ωστόσο οι γυναίκες που ενεργοποιούνται στο χώρο του αθλητισμού και επιδιώκουν να αναρριχηθούν σε θέσεις διοικητικής ευθύνης ή να ασκήσουν επιχειρηματικότητα στον χώρο αυτό, έχουν να υπερβούν πολλά εμπόδια. Μεταξύ άλλων επισημαίνονται: (1) οι προκαταλήψεις και τα στερεότυπα που ακόμα είναι κυρίαρχα και προκύπτουν από τις ανδροκεντρικές καταβολές του αθλητισμού, (2) η έλλειψη γυναικών μεντόρων, (3) η  έλλειψη γυναικών προτύπων, (4) οι άνισες ευκαιρίες εξέλιξης στην αθλητική ηγεσία σε σύγκριση με τους άνδρες, (5) η  έλλειψη ισορροπίας μεταξύ επαγγελματικής και ιδιωτικής/οικογενειακής ζωής. Απάντηση σε αυτή την υποεκπροσώπηση αποτελούν προγράμματα που προωθούν, προβάλλουν, και δημιουργούν γυναίκες μέντορες και κοινωνικά πρότυπα όπως εκείνο της Ελληνικής Ολυμπιακής Επιτροπής (ΕΟΕ) και του Συλλόγου Ελλήνων Ολυμπιονικών (ΣΕΟ) «Κάνουμε Χώρο για περισσότερες γυναίκες στην Αθλητική Συμμετοχή, την Προπονητική  Καθοδήγηση, και ειδικά τη Διοικητική Στελέχωση».   Λέξεις κλειδιά: κοινωνική ενσωμάτωση, φύλο, αθλητισμός, ηγεσία, επιχειρηματικότητα, «έμφυλη κόπωση» (gender fatigue), «σπατάλη ταλέντου» (wastage of talent),  «καμπύλη  ηλιθιότητας» (Stupid Curve), εξισορρόπηση επαγγελματικής και ιδιωτικής ζωής  
conference_proceedings._praktika_synedrioy_1st_edition_may_2017.pdf letter_of_acceptance_april_14_2017.pdf symposio_koinoniologias_toy_athlitismoy_metaneoterikes_proseggiseis_tis_athlitikis_drastiriotitas_kai_tis_fysikis_agogis.pdf
2016
Antonopoulou G, Magrioti V, Kokotou MG, Nikolaou A, Barbayianni E, Mouchlis VD, Dennis EA, Kokotos G. 2-Oxoamide inhibitors of cytosolic group IVA phospholipase A2 with reduced lipophilicity. Bioorganic and Medicinal Chemistry. 2016;24:4544-4554.Abstract
Cytosolic GIVA phospholipase A2 (GIVA cPLA2) initiates the eicosanoid pathway of inflammation and thus inhibitors of this enzyme constitute novel potential agents for the treatment of inflammatory diseases. Traditionally, GIVA cPLA2 inhibitors have suffered systemically from high lipophilicity. We have developed a variety of long chain 2-oxoamides as inhibitors of GIVA PLA2. Among them, AX048 was found to produce a potent analgesic effect. We have now reduced the lipophilicity of AX048 by replacing the long aliphatic chain with a chain containing an ether linked aromatic ring with in vitro inhibitory activities similar to AX048.
Anagnostaki L, Pavlopoulos V, Obradović J, Masten A, Motti-Stefanidi F. Academic resilience of immigrant youth in Greek schools: Personal and family resources. European Journal of Developmental Psychology. 2016;13(3):377-393.
Papaioannou TG, Karageorgopoulou TD, Sergentanis TN, Protogerou AD, Psaltopoulou T, Sharman JE, Weber T, Blacher J, Daskalopoulou SS, Wassertheurer S, et al. Accuracy of commercial devices and methods for noninvasive estimation of aortic systolic blood pressure a systematic review and meta-analysis of invasive validation studies. Journal of Hypertension [Internet]. 2016;34(7):1237 - 1248. Website
Maniatis S, Kamoutsis A, Chronopoulou-Sereli A, Nastos PT. Air Temperature Estimation Over the Ainos Mountain, Kefallinia Island Using Linear Regression Analysis. In: {Karacostas TS, Bais AF, Nastos PT} PERSPECTIVES ON ATMOSPHERIC SCIENCES. PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS: Aristotle Univ Thessaloniki, Sch Phys, Lab Atmospher Phys; Aristotle Univ Thessaloniki, Sch Geol, Dept Meteorol & Climatol; Hellen Meteorol Soc; Mariolopoulos Kanaginis Fdn Environm Sci; 2016. pp. 349-354.Abstract
Mountain Ainos is the highest mountain of the Ionian Islands with a maximum elevation of 1628 m. Its National Park is characterized by rich flora including endemic species such as Greek fir. In order to exploit fully its touristic potential, it is necessary to examine the mountain climate. However in situ measurements of climatic parameters in mountain areas pose difficulties as far as to access areas of interest. The current study addresses one specific object: Estimating the air temperature at different altitudes of the southeastern side of Mt. Ainos, having air temperature data at the exact same altitudes of the northwestern side which is more easily accessible. We performed linear regression analysis to estimate the mean, maximum and minimum daily air temperature of the southeastern sites from data measured at the northwestern one. The results are considered satisfactory in air temperature estimation at all examined altitudes. More accurate estimations were provided in the case of the mean air temperature at the altitude of 1580 m. Also, linear models indicated noticeable estimations of the minimum temperatures at 1300 and 1580 m.
Rousanoglou E, Noutsos K, Pappas A, Bogdanis G, Vagenas G, Bayios I, Bountolos K. Alterations of vertical jump mechanics after a half-marathon mountain running race. Journal of Sports Science and Medicine [Internet]. 2016;15(2):277-286. Publisher's VersionAbstract
The fatiguing effect of long-distance running has been examined in the context of a variety of parameters. However, there is scarcity of data regarding its effect on the vertical jump mechanics. The purpose of this study was to investigate the alterations of countermovement jump (CMJ) mechanics after a half-marathon mountain race. Twenty-seven runners performed CMJs before the race (Pre), immediately after the race (Post 1) and five minutes after Post 1 (Post 2). Instantaneous and ensemble-average analysis focused on jump height and, the maximum peaks and time-to-maximum peaks of: Displacement, vertical force (Fz), anterior-posterior force (Fx), Velocity and Power, in the eccentric (tECC) and concentric (tCON) phase of the jump, respectively. Repeated measures ANOVAs were used for statistical analysis (p ≤ 0.05). The jump height decrease was significant in Post 2 (-7.9%) but not in Post 1 (-4.1%). Fx and Velocity decreased significantly in both Post 1 (only in tECC) and Post 2 (both tECC and tCON). Α timing shift of the Fz peaks (earlier during tECC and later during tCON) and altered relative peak times (only in tECC) were also observed. Ensemble-average analysis revealed several time intervals of significant post-race alterations and a timing shift in the Fz-Velocity loop. An overall trend of lowered post-race jump output and mechanics was characterised by altered jump timing, restricted anterior-posterior movement and altered force-velocity relations. The specificity of mountain running fatigue to eccentric muscle work, appears to be reflected in the different time order of the post-race reductions, with the eccentric phase reductions preceding those of the concentric one. Thus, those who engage in mountain running should particularly consider downhill training to optimise eccentric muscular action.
rousanoglou_et_al._2016_-_jssm.pdf
Aissopou EK, Argyris AA, Nasothimiou EG, Konstantonis GD, Tampakis K, Tentolouris N, Papathanassiou M, Theodossiadis PG, Papaioannou TG, Stehouwer CDA, et al. Ambulatory Aortic Stiffness Is Associated With Narrow Retinal Arteriolar Caliber in Hypertensives: The SAFAR Study. American Journal of Hypertension [Internet]. 2016;29(5):626 - 633. Website
Weisel KC, Dimopoulos MA, Moreau P, Lacy MQ, Song KW, Delforge M, Karlin L, Goldschmidt H, Banos A, Oriol A, et al. Analysis of renal impairment in MM-003, a phase III study of pomalidomide + low‐dose dexamethasone versus high‐dose dexamethasone in refractory or relapsed and refractory multiple myeloma. Haematologica [Internet]. 2016;101(7):872 - 878. WebsiteAbstract
Pomalidomide + low-dose dexamethasone is effective and well tolerated for refractory or relapsed and refractory multiple myeloma after bortezomib and lenalidomide failure. The phase III trial MM-003 compared pomalidomide + low-dose dexamethasone with high-dose dexamethasone. This subanalysis grouped patients by baseline creatinine clearance ≥ 30 - < 60 mL/min (n=93, pomalidomide + low-dose dexamethasone; n=56, high-dose dexamethasone) or ≥ 60 mL/min (n=205, pomalidomide + low-dose dexamethasone; n=93, high-dose dexamethasone). Median progression-free survival was similar for both subgroups and favored pomalidomide + low-dose dexamethasone versus high-dose dexamethasone: 4.0 versus 1.9 months in the group with baseline creatinine clearance ≥ 30 - < 60 mL/min (P<0.001) and 4.0 versus 2.0 months in the group with baseline creatinine clearance ≥ 60 mL/min (P<0.001). Median overall survival for pomalidomide + low-dose dexamethasone versus high-dose dexamethasone was 10.4 versus 4.9 months (P=0.030) and 15.5 versus 9.2 months (P=0.133), respectively. Improved renal function, defined as an increase in creatinine clearance from < 60 to ≥ 60 mL/min, was similar in pomalidomide + low-dose dexamethasone and high-dose dexamethasone patients (42% and 47%, respectively). Improvement in progression-free and overall survival in these patients was comparable with that in patients without renal impairment. There was no increase in discontinuations of therapy, dose modifications, and adverse events in patients with moderate renal impairment. Pomalidomide at a starting dose of 4 mg + low-dose dexamethasone is well tolerated in patients with refractory or relapsed and refractory multiple myeloma, and of comparable efficacy if moderate renal impairment is present. © 2016 Ferrata Storti Foundation.
Magkoutis NA, Fradi S, Azmoun A, Ramadan R, Ouanes SB, Vavuranakis M, Vrachatis DA, Papaioannou TG, Tousoulis D, Ghostine S. Antiplatelet therapy in TAVI: Current clinical practice and recommendations. Current Pharmaceutical Design [Internet]. 2016;22(13):1888 - 1895. Website
Paraskevis D, Nikolopoulos GK, Magiorkinis G, Hodges-Mameletzis I, Hatzakis A. The application of HIV molecular epidemiology to public health. Infect Genet Evol. 2016;46:159-168.Abstract
HIV is responsible for one of the largest viral pandemics in human history. Despite a concerted global response for prevention and treatment, the virus persists. Thus, urgent public health action, utilizing novel interventions, is needed to prevent future transmission events, critical to eliminating HIV. For public health planning to prove effective and successful, we need to understand the dynamics of regional epidemics and to intervene appropriately. HIV molecular epidemiology tools as implemented in phylogenetic, phylodynamic and phylogeographic analyses have proven to be powerful tools in public health planning across many studies. Numerous applications with HIV suggest that molecular methods alone or in combination with mathematical modelling can provide inferences about the transmission dynamics, critical epidemiological parameters (prevalence, incidence, effective number of infections, Re, generation times, time between infection and diagnosis), or the spatiotemporal characteristics of epidemics. Molecular tools have been used to assess the impact of an intervention and outbreak investigation which are of great public health relevance. In some settings, molecular sequence data may be more readily available than HIV surveillance data, and can therefore allow for molecular analyses to be conducted more easily. Nonetheless, classic methods have an integral role in monitoring and evaluation of public health programmes, and should supplement emerging techniques from the field of molecular epidemiology. Importantly, molecular epidemiology remains a promising approach in responding to viral diseases.
Papaioannou TG, Karatzi K, Psaltopoulou T, Tousoulis D. Arterial ageing: Major nutritional and life-style effects. Ageing Research Reviews [Internet]. 2016. Website
Kontakiotis, G., Mortyn, P.G., Antonarakou, A., Drinia, H. Assessing the reliability of foraminiferal Mg/Ca thermometry by comparing field-samples and culture experiments: a review. Geological Quarterly [Internet]. 2016;60(3). Publisher's Version
Nastos PT, Moustris KP, Charalampopoulos I, Larissi IK, Paliatsos AG. Assessment of the Thermal Comfort Conditions in a University Campus Using a 3D Microscale Climate Model, Utilizing Mobile Measurements. In: {Karacostas TS, Bais AF, Nastos PT} PERSPECTIVES ON ATMOSPHERIC SCIENCES. {PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS}: {Aristotle Univ Thessaloniki, Sch Phys, Lab Atmospher Phys; Aristotle Univ Thessaloniki, Sch Geol, Dept Meteorol & Climatol; Hellen Meteorol Soc; Mariolopoulos Kanaginis Fdn Environm Sci}; 2016. pp. 309-315.Abstract
The objective of the study is to assess the human thermal comfort at a University Campus in the metropolitan area of Athens. The equipment setup consists of all the necessary sensors for human thermal comfort estimation along with a high resolution GPS, mounted on a cargo bicycle. The experiment was carried out for midday and night on July 29, 2015. Besides, long term 5 min measurements from a meteorological station, established on the roof of a building within the University Campus, were also used to quantify the mean thermal environment. The densely carried out bicycle measurements every 5 s was the input data utilized by the ENVI-met model; a three-dimensional microclimate model designed to simulate the surface-plant-air interactions in urban environment. The in situ measurements along with the model's output results reveal the thermal comfort regime of the selected area and the ability of the model to estimate accurately the micrometeorological conditions.
Triantafyllou N, Thoda P, Armeni E, Rizos D, Kaparos G, Augoulea A, Alexandrou A, Creatsa M, Tsivgoulis G, Artemiades A, et al. Association of sex hormones and glucose metabolism with the severity of multiple sclerosis. International Journal of Neuroscience [Internet]. 2016;126:797-804. Website
Burnetas A, Kanavetas O, Katehakis MN. ASYMPTOTICALLY OPTIMAL MULTI-ARMED BANDIT POLICIES UNDER A COST CONSTRAINT. Probability in the Engineering and Informational Sciences [Internet]. 2016:1-27. WebsiteAbstract
We consider the multi-armed bandit problem under a cost constraint. Successive samples from each population are i.i.d. with unknown distribution and each sample incurs a known population-dependent cost. The objective is to design an adaptive sampling policy to maximize the expected sum of n samples such that the average cost does not exceed a given bound sample-path wise. We establish an asymptotic lower bound for the regret of feasible uniformly fast convergent policies, and construct a class of policies, which achieve the bound. We also provide their explicit form under Normal distributions with unknown means and known variances. Copyright © Cambridge University Press 2016
Dimopoulos MA, Sonneveld P, Sun H. The author and colleagues reply: Bueno. New England Journal of Medicine [Internet]. 2016;375(25):2497 - 2498. Website
Dimopoulos MA, Sonneveld P, Sun H. The author and colleagues reply: Bueno. New England Journal of Medicine [Internet]. 2016;375(25):2497 - 2498. Website
Krys K, Vauclair C-M, Capaldi CA, Lun VM-C, Bond MH, Domínguez-Espinosa A, Torres C, Lipp OV, Manickam SLS, Xing C. Be careful where you smile: culture shapes judgments of intelligence and honesty of smiling individuals. Journal of Nonverbal Behavior. 2016;40(2):101-116.
Vrontaki E, Melagraki G, Afantitis A, Mavromoustakos T. Beta-thalassaemia and therapeutic approaches. Pharmakeftiki [Internet]. 2016;28(3):108 - 116. Website
MOISSETTE, P., KOSKERIDOU, E., Drinia, H., Cornee, J.-J. Biofacies in warm-temperate siliciclastic deposits – Insights from the Early Pleistocene of the eastern Mediterranean (Rhodes, Greece). Geological Magazine [Internet]. 2016;153:61-83. Publisher's Version
Koukoulitsa C, Villalonga-Barber C, Csonka R, Alexi X, Leonis G, Dellis D, Hamelink E, Belda O, Steele BR, Micha-Screttas M, et al. Biological and computational evaluation of resveratrol inhibitors against Alzheimers disease. Journal of Enzyme Inhibition and Medicinal Chemistry [Internet]. 2016;31(1):67 - 77. Website
Pafilis P, Meiri S, Sagonas K, Karakasi D, Kourelou E, Valakos ED. Body size affects digestive performance in a Mediterranean lizard. The Herpetological Journal. 2016;26(3):199-205.
Dimopoulos MA, Roussou M, Gavriatopoulou M, Psimenou E, Eleutherakis-Papaiakovou E, Migkou M, Matsouka C, Mparmparousi D, Gika D, Kafantari E, et al. Bortezomib-based triplets are associated with a high probability of dialysis independence and rapid renal recovery in newly diagnosed myeloma patients with severe renal failure or those requiring dialysis. American Journal of Hematology [Internet]. 2016;91(5):499 - 502. WebsiteAbstract
Renal failure (RF) is a common and severe complication of symptomatic myeloma, associated with significant morbidity and mortality. Such patients are commonly excluded from clinical trials. Bortezomib/dexamethasone (VD)-based regimens are the backbone of the treatment of newly diagnosed MM patients who present with severe RF even those requiring dialysis. We analyzed the outcomes of 83 consecutive bortezomib-treated patients with severe RF (eGFR<30 ml/min/1.73 m2), of which 31 (37%) required dialysis. By IMWG renal response criteria, 54 (65%) patients achieved at least MRrenal, including CRrenal in 35% and PRrenal in 12%. Triplet combinations (i.e., VD plus a third agent) versus VD alone were associated with higher rates of renal responses (72 vs. 50%; P=0.06). Fifteen of the 31 (48%) patients became dialysis independent within a median of 217 days (range 11-724). Triplets were associated with a higher probability of dialysis discontinuation (57 vs. 35%). Serum free light chain (sFLC) level ≥11,550 mg/L was associated with lower rates of major renal response, longer time to major renal response, lower probability, and longer time to dialysis discontinuation. Rapid myeloma response (≥PR within the first month) was also associated with higher rates of renal response. Patients who became dialysis-independent had longer survival than those remaining on dialysis. In conclusion, VD-based triplets are associated with a significant probability of renal response and dialysis discontinuation, improving the survival of patients who became dialysis independent. Rapid disease response is important for renal recovery and sFLCs are predictive of the probability and of the time required for renal response. © 2016 Wiley Periodicals, Inc.
Dimopoulos MA, Roussou M, Gavriatopoulou M, Psimenou E, Eleutherakis-Papaiakovou E, Migkou M, Matsouka C, Mparmparousi D, Gika D, Kafantari E, et al. Bortezomib-based triplets are associated with a high probability of dialysis independence and rapid renal recovery in newly diagnosed myeloma patients with severe renal failure or those requiring dialysis. American Journal of Hematology [Internet]. 2016;91(5):499 - 502. WebsiteAbstract
Renal failure (RF) is a common and severe complication of symptomatic myeloma, associated with significant morbidity and mortality. Such patients are commonly excluded from clinical trials. Bortezomib/dexamethasone (VD)-based regimens are the backbone of the treatment of newly diagnosed MM patients who present with severe RF even those requiring dialysis. We analyzed the outcomes of 83 consecutive bortezomib-treated patients with severe RF (eGFR<30 ml/min/1.73 m2), of which 31 (37%) required dialysis. By IMWG renal response criteria, 54 (65%) patients achieved at least MRrenal, including CRrenal in 35% and PRrenal in 12%. Triplet combinations (i.e., VD plus a third agent) versus VD alone were associated with higher rates of renal responses (72 vs. 50%; P=0.06). Fifteen of the 31 (48%) patients became dialysis independent within a median of 217 days (range 11-724). Triplets were associated with a higher probability of dialysis discontinuation (57 vs. 35%). Serum free light chain (sFLC) level ≥11,550 mg/L was associated with lower rates of major renal response, longer time to major renal response, lower probability, and longer time to dialysis discontinuation. Rapid myeloma response (≥PR within the first month) was also associated with higher rates of renal response. Patients who became dialysis-independent had longer survival than those remaining on dialysis. In conclusion, VD-based triplets are associated with a significant probability of renal response and dialysis discontinuation, improving the survival of patients who became dialysis independent. Rapid disease response is important for renal recovery and sFLCs are predictive of the probability and of the time required for renal response. © 2016 Wiley Periodicals, Inc.
Evangelinos M, Martzoukou O, Chorozian K, Amillis S, Diallinas G. BsdA(Bsd2) -dependent vacuolar turnover of a misfolded version of the UapA transporter along the secretory pathway: Prominent role of selective autophagy. Mol Microbiol. 2016.Abstract
Transmembrane proteins translocate co-translationally in the endoplasmic reticulum (ER) membrane and traffic as vesicular cargoes, via the Golgi, in their final membrane destination. Misfolding in the ER leads to protein degradation basically through the ERAD/proteasome system. Here, we use a mutant version of the purine transporter UapA (ΔR481) to show that specific misfolded versions of plasma membrane cargoes undergo vacuolar turnover prior to localization in the plasma membrane. We show that non-endocytic vacuolar turnover of ΔR481 is dependent on BsdA(Bsd2) , an ER transmembrane adaptor of HulA(Rsp5) ubiquitin ligase. We obtain in vivo evidence that BsdA(Bsd2) interacts with HulA(Rsp5) and ΔR481, primarily in the ER. Importantly, accumulation of ΔR481 in the ER triggers delivery of the selective autophagy marker Atg8 in vacuoles along with ΔR481. Genetic block of autophagy (atg9Δ, rabO(ts) ) reduces, but does not abolish, sorting of ΔR481 in the vacuoles, suggesting that a fraction of the misfolded transporter might be redirected for vacuolar degradation via the Golgi. Our results support that multiple routes along the secretory pathway operate for the detoxification of Aspergillus nidulans cells from misfolded membrane proteins, and that BsdA is key factor for marking specific misfolded cargoes. This article is protected by copyright. All rights reserved.
Karakurt S, Kellici TF, Mavromoustakos T, Tzakos AG, Yilmaz M. Calixarenes in lipase biocatalysis and cancer therapy. Current Organic Chemistry [Internet]. 2016;20(10):1043 - 1057. Website
Dimopoulos MA, Moreau P, Palumbo A, Chng W-J, Feng S. Carfilozomib versus bortezomib for relapsed or refractory myeloma – Authors' reply. The Lancet Oncology [Internet]. 2016;17(4):e126. Website
Dimopoulos MA, Moreau P, Palumbo A, Chng W-J, Feng S. Carfilozomib versus bortezomib for relapsed or refractory myeloma – Authors' reply. The Lancet Oncology [Internet]. 2016;17(4):e126. Website
Dimopoulos MA, Moreau P, Palumbo A, Joshua D, Pour L, Hájek R, Facon T, Ludwig H, Oriol A, Goldschmidt H, et al. Carfilzomib and dexamethasone versus bortezomib and dexamethasone for patients with relapsed or refractory multiple myeloma (ENDEAVOR): And randomised, phase 3, open-label, multicentre study. The Lancet Oncology [Internet]. 2016;17(1):27 - 38. WebsiteAbstract
Background: Bortezomib with dexamethasone is a standard treatment option for relapsed or refractory multiple myeloma. Carfilzomib with dexamethasone has shown promising activity in patients in this disease setting. The aim of this study was to compare the combination of carfilzomib and dexamethasone with bortezomib and dexamethasone in patients with relapsed or refractory multiple myeloma. Methods: In this randomised, phase 3, open-label, multicentre study, patients with relapsed or refractory multiple myeloma who had one to three previous treatments were randomly assigned (1:1) using a blocked randomisation scheme (block size of four) to receive carfilzomib with dexamethasone (carfilzomib group) or bortezomib with dexamethasone (bortezomib group). Randomisation was stratified by previous proteasome inhibitor therapy, previous lines of treatment, International Staging System stage, and planned route of bortezomib administration if randomly assigned to bortezomib with dexamethasone. Patients received treatment until progression with carfilzomib (20 mg/m2 on days 1 and 2 of cycle 1; 56 mg/m2 thereafter; 30 min intravenous infusion) and dexamethasone (20 mg oral or intravenous infusion) or bortezomib (1·3 mg/m2; intravenous bolus or subcutaneous injection) and dexamethasone (20 mg oral or intravenous infusion). The primary endpoint was progression-free survival in the intention-to-treat population. All participants who received at least one dose of study drug were included in the safety analyses. The study is ongoing but not enrolling participants; results for the interim analysis of the primary endpoint are presented. The trial is registered at ClinicalTrials.gov, number NCT01568866. Findings: Between June 20, 2012, and June 30, 2014, 929 patients were randomly assigned (464 to the carfilzomib group; 465 to the bortezomib group). Median follow-up was 11·9 months (IQR 9·3-16·1) in the carfilzomib group and 11·1 months (8·2-14·3) in the bortezomib group. Median progression-free survival was 18·7 months (95% CI 15·6-not estimable) in the carfilzomib group versus 9·4 months (8·4-10·4) in the bortezomib group at a preplanned interim analysis (hazard ratio [HR] 0·53 [95% CI 0·44-0·65]; p<0·0001). On-study death due to adverse events occurred in 18 (4%) of 464 patients in the carfilzomib group and in 16 (3%) of 465 patients in the bortezomib group. Serious adverse events were reported in 224 (48%) of 463 patients in the carfilzomib group and in 162 (36%) of 456 patients in the bortezomib group. The most frequent grade 3 or higher adverse events were anaemia (67 [14%] of 463 patients in the carfilzomib group vs 45 [10%] of 456 patients in the bortezomib group), hypertension (41 [9%] vs 12 [3%]), thrombocytopenia (39 [8%] vs 43 [9%]), and pneumonia (32 [7%] vs 36 [8%]). Interpretation: For patients with relapsed or refractory multiple myeloma, carfilzomib with dexamethasone could be considered in cases in which bortezomib with dexamethasone is a potential treatment option. Funding: Onyx Pharmaceuticals, Inc., an Amgen subsidiary. © 2016 Elsevier Ltd.
Ziogas DC, Terpos E, Kastritis E, Dimopoulos MA. Carfilzomib for treating myeloma. Expert Opinion on Orphan Drugs [Internet]. 2016;4(9):989 - 999. WebsiteAbstract
Introduction: Carfilzomib, a second-generation proteasome inhibitor, has been increasingly used in relapsed/refractory multiple myeloma (MM) since its initial approval by the Food and Drug Administration in 2012, either as a single agent or in combination with other known anti-myeloma treatments. Based on its efficacy and safety profile in the relapsed/refractory setting, carfilzomib is currently evaluated in patients with de novo MM. Areas covered: Here, we will shed some light on the introduction of carfilzomib as an effective anti-myeloma treatment, presenting its mechanism of action, its response rates and adverse events, as well as a summary of all clinical trials evaluating current dosage and schedule of administration. We will follow the entire path of drug’s development from the bench of preclinical studies to the market and bedside delivery. Revising the published evidence, we will try to answer all questions raised about the novel drug, expressing in parallel our site experience. Expert opinion: Carfilzomib, alone or in combination with other agents, is a welcome therapeutic option for MM patients with a well-defined toxicity profile. Results of ongoing trials are expected in order to update drug indications and maximize its therapeutic benefits in patients with refractory/relapse MM. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
Ziogas DC, Terpos E, Kastritis E, Dimopoulos MA. Carfilzomib for treating myeloma. Expert Opinion on Orphan Drugs [Internet]. 2016;4(9):989 - 999. WebsiteAbstract
Introduction: Carfilzomib, a second-generation proteasome inhibitor, has been increasingly used in relapsed/refractory multiple myeloma (MM) since its initial approval by the Food and Drug Administration in 2012, either as a single agent or in combination with other known anti-myeloma treatments. Based on its efficacy and safety profile in the relapsed/refractory setting, carfilzomib is currently evaluated in patients with de novo MM. Areas covered: Here, we will shed some light on the introduction of carfilzomib as an effective anti-myeloma treatment, presenting its mechanism of action, its response rates and adverse events, as well as a summary of all clinical trials evaluating current dosage and schedule of administration. We will follow the entire path of drug’s development from the bench of preclinical studies to the market and bedside delivery. Revising the published evidence, we will try to answer all questions raised about the novel drug, expressing in parallel our site experience. Expert opinion: Carfilzomib, alone or in combination with other agents, is a welcome therapeutic option for MM patients with a well-defined toxicity profile. Results of ongoing trials are expected in order to update drug indications and maximize its therapeutic benefits in patients with refractory/relapse MM. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
Avet-Loiseau H, Fonseca R, Siegel D, Dimopoulos MA, Špička I, Masszi T, Hájek R, Rosiñol L, Goranova-Marinova V, Mihaylov G, et al. Carfilzomib significantly improves the progression-free survival of high-risk patients in multiple myeloma. Blood [Internet]. 2016;128(9):1174 - 1180. WebsiteAbstract
The presence of certain high-risk cytogenetic abnormalities, such as translocations (4;14) and (14;16) and deletion (17p), are known to have a negative impact on survival in multiple myeloma (MM). The phase 3 study ASPIRE (N = 792) demonstrated that progression-free survival (PFS) was significantly improved with carfilzomib, lenalidomide, and dexamethasone (KRd), compared with lenalidomide and dexamethasone (Rd) in relapsed MM. This preplanned subgroup analysis of ASPIRE was conducted to evaluate KRd vs Rd by baseline cytogenetics according to fluorescence in situ hybridization. Of 417 patients with known cytogenetic risk status, 100 patients (24%) were categorized with high-risk cytogenetics (KRd, n548; Rd, n552) and 317 (76%) were categorized with standard-risk cytogenetics (KRd, n = 147; Rd, n = 170). For patients with high-risk cytogenetics, treatment with KRd resulted in a median PFS of 23.1 months, a 9-month improvement relative to treatment with Rd. For patients with standard-risk cytogenetics, treatment with KRd led to a 10-month improvement in median PFS vs Rd. The overall response rates for KRd vs Rd were 79.2% vs 59.6% (high-risk cytogenetics) and 91.2% vs 73.5% (standardrisk cytogenetics); approximately fivefold as many patients with high- or standard-risk cytogenetics achieved a complete response or better with KRd vs Rd (29.2% vs 5.8% and 38.1% vs 6.5%, respectively). KRd improved but did not abrogate the poor prognosis associated with high-risk cytogenetics. This regimen had a favorable benefit-risk profile in patients with relapsed MM, irrespective of cytogenetic risk status, and should be considered a standard of care in these patients. Copyright © 2011 by the American Association for the Advancement of Science; all rights reserved.
Avet-Loiseau H, Fonseca R, Siegel D, Dimopoulos MA, Špička I, Masszi T, Hájek R, Rosiñol L, Goranova-Marinova V, Mihaylov G, et al. Carfilzomib significantly improves the progression-free survival of high-risk patients in multiple myeloma. Blood [Internet]. 2016;128(9):1174 - 1180. WebsiteAbstract
The presence of certain high-risk cytogenetic abnormalities, such as translocations (4;14) and (14;16) and deletion (17p), are known to have a negative impact on survival in multiple myeloma (MM). The phase 3 study ASPIRE (N = 792) demonstrated that progression-free survival (PFS) was significantly improved with carfilzomib, lenalidomide, and dexamethasone (KRd), compared with lenalidomide and dexamethasone (Rd) in relapsed MM. This preplanned subgroup analysis of ASPIRE was conducted to evaluate KRd vs Rd by baseline cytogenetics according to fluorescence in situ hybridization. Of 417 patients with known cytogenetic risk status, 100 patients (24%) were categorized with high-risk cytogenetics (KRd, n548; Rd, n552) and 317 (76%) were categorized with standard-risk cytogenetics (KRd, n = 147; Rd, n = 170). For patients with high-risk cytogenetics, treatment with KRd resulted in a median PFS of 23.1 months, a 9-month improvement relative to treatment with Rd. For patients with standard-risk cytogenetics, treatment with KRd led to a 10-month improvement in median PFS vs Rd. The overall response rates for KRd vs Rd were 79.2% vs 59.6% (high-risk cytogenetics) and 91.2% vs 73.5% (standardrisk cytogenetics); approximately fivefold as many patients with high- or standard-risk cytogenetics achieved a complete response or better with KRd vs Rd (29.2% vs 5.8% and 38.1% vs 6.5%, respectively). KRd improved but did not abrogate the poor prognosis associated with high-risk cytogenetics. This regimen had a favorable benefit-risk profile in patients with relapsed MM, irrespective of cytogenetic risk status, and should be considered a standard of care in these patients. Copyright © 2011 by the American Association for the Advancement of Science; all rights reserved.
Lymberakis P, Valakos ED, Sagonas K, Pafilis P. The castaway: characteristic islet features affect the ecology of the most isolated European lizard. Acta Herpetologica. 2016;11(2):161-169.
Rizos D. Catalog of unified nomenclature and coding of laboratory tests. Archives of Hellenic Medicine [Internet]. 2016;33:420-421. Website
Rizos D, Belesi C, Grouzi E, Manolis I, Stylianakis A, Themeli-Digalaki K, Karakitsos P, Tsioli P, Siorenda A, Vrani V, et al. Catalog of uniform nomenclature and coding of laboratory tests. Archives of Hellenic Medicine. 2016;32(6):777 - 788.Abstract
© Athens Medical Society. In March 2013, the Health Procurement Committee of the Greek Ministry of Health appointed a committee consisting of laboratory scientists to compile a list of laboratory tests performed on biological fluids, cells and tissues. This committee compiled a list entitled Catalog of Uniform Nomenclature and Coding of Laboratory Tests (CUNCLT), using as its basis the list of reagents of the European Diagnostics Manufacturers Association (EDMA). The CUNCLT refers to the nomenclature of the laboratory tests and does not include all the materials (reagents, consumables, solutions, calibrators, controls, equipment, etc.) and software that may be necessary for performing the tests. The CUNCLT categorizes the laboratory tests that are performed on biological fluids, cells and tissues into eight main categories, each including subcategories of the 1st and 2nd levels. The eight main categories of the CUNCLT, namely Clinical Chemistry- Biochemistry, Immunochemistry, Hematology, Microbiology (cultures), Infectious Immunology, Molecular Biology and Genetics, Pathology-Cytology, Immunology, generally correspond to the categories of clinical laboratories that operate in public hospitals. The CUNCLT includes a total of 2,403 tests and according to its creation rationale, it is imperative that this list is regularly updated. CUNCLT is an important effort at the recording and classification of the laboratory tests carried out in clinical laboratories on biological fluids, cells and tissues. This list could be the basis for introducing the coding of laboratory tests in the laboratory information systems of public hospitals, for matching with the codes of laboratory tests prescribed by the National Organization for Health Care Services (EOPYY) and for specifications for the purchase of the reagents for laboratory testing.
Vrachatis DA, Papaioannou TG, Protogerou AD. Central blood pressure measurement. In: Hypertension and Cardiovascular Disease. ; 2016. pp. 49 - 58. Website
Liakou CG, Mastorakos G, Makris K, Fatouros IG, Avloniti A, Marketos H, Antoniou JD, Galanos A, Dontas I, Rizos D, et al. Changes of serum sclerostin and Dickkopf-1 levels during the menstrual cycle. A pilot study. Endocrine [Internet]. 2016;54:543-551. Website
Caers J, de Larrea CF, Leleu X, Heusschen R, Zojer N, Decaux O, Kastritis E, Minnema M, Jurczyszyn A, Beguin Y, et al. The changing landscape of smoldering multiple myeloma: A european perspective. Oncologist [Internet]. 2016;21(3):333 - 342. WebsiteAbstract
Smoldering multiple myeloma (SMM) is an asymptomatic clonal plasma cell disorder and bridges monoclonal gammo- pathyof undetermined significance to multiple myeloma (MM), based on higher levels of circulating monoclonal immunoglobulin and bone marrow plasmocytosis without end-organ damage. Until a Spanish study reported fewer MM-related events and better overall survival among patients with high- risk SMM treated with lenalidomide and dexamethasone, prior studies had failed to show improved survival with earlier intervention,although a reduction in skeletal-related events (without any impact on disease progression) has been described with bisphosphonate use. Risk factors have now been defined, and a subset of ultra-high-risk patients have been reclassified by the International Myeloma Working Group as MM, and thus will require optimal MM treatment, based on biomarkers that identify patients with a >80% risk of progression. The number of these redefined patients is small (~10%), but important to unravel, because theirriskof progression to overt MM is substantial ($80% within 2 years). Patients with a high-risk cytogenetic profile are not yet considered for early treatment, because groups are heterogeneous and risk factors other than cytogenetics are deemed to weight higher. Because patients with ultra-high- risk SMM are now considered as MM and may be treated as such, concerns exist that earlier therapy may increase the risk of selecting resistant clones and induce side effects and costs. Therefore, an even more accurate identification of patients who would benefit from interventions needs to be performed, and clinical judgment and careful discussion of pros and cons of treatment initiation need to be undertaken. For the majority of SMM patients, the standard of care remains observation until development of symptomatic MM occurs, encouraging participation in ongoing and upcoming SMM/early MM clinical trials, as well as consideration of bisphosphonate use in patients with early bone loss. © AlphaMed Press 2016.
Caers J, de Larrea CF, Leleu X, Heusschen R, Zojer N, Decaux O, Kastritis E, Minnema M, Jurczyszyn A, Beguin Y, et al. The changing landscape of smoldering multiple myeloma: A european perspective. Oncologist [Internet]. 2016;21(3):333 - 342. WebsiteAbstract
Smoldering multiple myeloma (SMM) is an asymptomatic clonal plasma cell disorder and bridges monoclonal gammo- pathyof undetermined significance to multiple myeloma (MM), based on higher levels of circulating monoclonal immunoglobulin and bone marrow plasmocytosis without end-organ damage. Until a Spanish study reported fewer MM-related events and better overall survival among patients with high- risk SMM treated with lenalidomide and dexamethasone, prior studies had failed to show improved survival with earlier intervention,although a reduction in skeletal-related events (without any impact on disease progression) has been described with bisphosphonate use. Risk factors have now been defined, and a subset of ultra-high-risk patients have been reclassified by the International Myeloma Working Group as MM, and thus will require optimal MM treatment, based on biomarkers that identify patients with a >80% risk of progression. The number of these redefined patients is small (~10%), but important to unravel, because theirriskof progression to overt MM is substantial ($80% within 2 years). Patients with a high-risk cytogenetic profile are not yet considered for early treatment, because groups are heterogeneous and risk factors other than cytogenetics are deemed to weight higher. Because patients with ultra-high- risk SMM are now considered as MM and may be treated as such, concerns exist that earlier therapy may increase the risk of selecting resistant clones and induce side effects and costs. Therefore, an even more accurate identification of patients who would benefit from interventions needs to be performed, and clinical judgment and careful discussion of pros and cons of treatment initiation need to be undertaken. For the majority of SMM patients, the standard of care remains observation until development of symptomatic MM occurs, encouraging participation in ongoing and upcoming SMM/early MM clinical trials, as well as consideration of bisphosphonate use in patients with early bone loss. © AlphaMed Press 2016.
Marouga A, Dalamaga M, Kastania AN, Kroupis C, Lagiou M, Saounatsou K, Dimas K, Vlahakos DV. Circulating resistin is a significant predictor of mortality independently from cardiovascular comorbidities in elderly, non-diabetic subjects with chronic kidney disease. Biomarkers. 2016;21(1):73-9.Abstract
CONTEXT: Resistin is associated with inflammation, atherosclerosis and cardiovascular (CV) disease. OBJECTIVE: To associate circulating resistin with all-cause and CV mortality in chronic kidney disease (CKD) patients. METHODS: Serum resistin was determined in a cohort of 80 elderly, non-diabetic patients with stable CKD at different stages in a follow-up period of 5 years. RESULTS: Circulating resistin was significantly elevated in deceased compared to alive patients. Resistin emerged as an independent biomarker of all-cause and CV mortality after a 5-year follow-up period. CONCLUSION: Elevated circulating resistin was a significant independent predictor of CV and all-cause mortality in elderly, non-diabetic CKD patients.
Gogou A, Triantaphyllou M, Xoplaki E, Izdebski A, Parinos C, Dimiza M, Bouloubassi I, Luterbacher J, Kouli K, Martrat B, et al. Climate variability and socio-environmental changes in the northern Aegean (NE Mediterranean) during the last 1500 years. Quaternary Science Reviews [Internet]. 2016;136:209–228. Publisher's VersionAbstract
AbstractWe provide new evidence on sea surface temperature (SST) variations and paleoceanographic/paleoenvironmental changes over the past 1500 years for the north Aegean Sea (NE Mediterranean). The reconstructions are based on multiproxy analyses, obtained from the high resolution (decadal to multi-decadal) marine record M2 retrieved from the Athos basin. Reconstructed SSTs show an increase from ca. 850 to 950 AD and from ca. 1100 to 1300 AD. A cooling phase of almost 1.5 °C is observed from ca. 1600 AD to 1700 AD. This seems to have been the starting point of a continuous SST warming trend until the end of the reconstructed period, interrupted by two prominent cooling events at 1832 ± 15 AD and 1995 ± 1 AD. Application of an adaptive Kernel smoothing suggests that the current warming in the reconstructed SSTs of the north Aegean might be unprecedented in the context of the past 1500 years. Internal variability in atmospheric/oceanic circulations systems as well as external forcing as solar radiation and volcanic activity could have affected temperature variations in the north Aegean Sea over the past 1500 years. The marked temperature drop of approximately ∼2 °C at 1832 ± 15 yr AD could be related to the 1809 ΑD ‘unknown’ and the 1815 AD Tambora volcanic eruptions. Paleoenvironmental proxy-indices of the M2 record show enhanced riverine/continental inputs in the northern Aegean after ca. 1450 AD. The paleoclimatic evidence derived from the M2 record is combined with a socio-environmental study of the history of the north Aegean region. We show that the cultivation of temperature-sensitive crops, i.e. walnut, vine and olive, co-occurred with stable and warmer temperatures, while its end coincided with a significant episode of cooler temperatures. Periods of agricultural growth in Macedonia coincide with periods of warmer and more stable SSTs, but further exploration is required in order to identify the causal links behind the observed phenomena. The Black Death likely caused major changes in agricultural activity in the north Aegean region, as reflected in the pollen data from land sites of Macedonia and the M2 proxy-reconstructions. Finally, we conclude that the early modern peaks in mountain vegetation in the Rhodope and Macedonia highlands, visible also in the M2 record, were very likely climate-driven.
Gogou A, Triantaphyllou M, Xoplaki E, Izdebski A, Parinos C, Dimiza M, Bouloubassi I, Luterbacher J, Kouli K, Martrat B, et al. Climate variability and socio-environmental changes in the northern Aegean (NE Mediterranean) during the last 1500 years. Quaternary Science Reviews [Internet]. 2016;136:209-228. Publisher's VersionAbstract
We provide new evidence on sea surface temperature (SST) variations and paleoceanographic/paleoenvironmental changes over the past 1500 years for the north Aegean Sea (NE Mediterranean). The reconstructions are based on multiproxy analyses, obtained from the high resolution (decadal to multi-decadal) marine record M2 retrieved from the Athos basin. Reconstructed SSTs show an increase from ca. 850 to 950 AD and from ca. 1100 to 1300 AD. A cooling phase of almost 1.5 °C is observed from ca. 1600 AD to 1700 AD. This seems to have been the starting point of a continuous SST warming trend until the end of the reconstructed period, interrupted by two prominent cooling events at 1832 ± 15 AD and 1995 ± 1 AD. Application of an adaptive Kernel smoothing suggests that the current warming in the reconstructed SSTs of the north Aegean might be unprecedented in the context of the past 1500 years. Internal variability in atmospheric/oceanic circulations systems as well as external forcing as solar radiation and volcanic activity could have affected temperature variations in the north Aegean Sea over the past 1500 years. The marked temperature drop of approximately ∼2 °C at 1832 ± 15 yr AD could be related to the 1809 ΑD ‘unknown’ and the 1815 AD Tambora volcanic eruptions. Paleoenvironmental proxy-indices of the M2 record show enhanced riverine/continental inputs in the northern Aegean after ca. 1450 AD.The paleoclimatic evidence derived from the M2 record is combined with a socio-environmental study of the history of the north Aegean region. We show that the cultivation of temperature-sensitive crops, i.e. walnut, vine and olive, co-occurred with stable and warmer temperatures, while its end coincided with a significant episode of cooler temperatures. Periods of agricultural growth in Macedonia coincide with periods of warmer and more stable SSTs, but further exploration is required in order to identify the causal links behind the observed phenomena. The Black Death likely caused major changes in agricultural activity in the north Aegean region, as reflected in the pollen data from land sites of Macedonia and the M2 proxy-reconstructions. Finally, we conclude that the early modern peaks in mountain vegetation in the Rhodope and Macedonia highlands, visible also in the M2 record, were very likely climate-driven.
Kotsakiozi P, Parmakelis A, Konstantakis A, Valakos ED. Climatic conditions driving a part of changes in the biochemical composition in land snails: Insights from the endangered Codringtonia (Gastropoda: Pulmonata). Biologia. 2016;71(8):903-916.
Philandras CM, Kapsomenakis J, Nastos PT, Repapis C, Zerefos CS. Climatology of Upper Air Temperature Over the Mediterranean. Trends and Variability. In: {Karacostas TS, Bais AF, Nastos PT} PERSPECTIVES ON ATMOSPHERIC SCIENCES. {PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS}: {Aristotle Univ Thessaloniki, Sch Phys, Lab Atmospher Phys; Aristotle Univ Thessaloniki, Sch Geol, Dept Meteorol & Climatol; Hellen Meteorol Soc; Mariolopoulos Kanaginis Fdn Environm Sci}; 2016. pp. 565-576.Abstract
{This study shed light on the long term air temperature changes in the troposphere over the Mediterranean. For this purpose, we utilized the radiosonde datasets for the barometric levels at 850, 700, 500, 300, 200, 150, and 100 hPa from seventeen meteorological stations within the Mediterranean, for the period 1965-2015. Besides, the gridded reanalysis products of upper air temperature for the respective barometric pressure levels from the European Centre for Medium-Range Weather Forecasts (ECMWF, ERA-Interim) and the National Center for Environmental Prediction-National Center for Atmospheric Research (NCEPNCAR) were used and compared to stations' datasets. We analyzed the trends and variability of upper air temperature on seasonal and annual basis. The impact of atmospheric circulation, by means of specific climatic indices such as Mediterranean Oscillation Index (MOI), North Sea Caspian Pattern Index (NCPI) and North Atlantic Oscillation Index (NAOI), was also examined. The results of our analysis indicate the anthropogenic forcing to climate variability, especially in lower/middle troposphere against upper troposphere over the Mediterranean.}
Kastritis E, Papassotiriou I, Terpos E, Roussou M, Gavriatopoulou M, Komitopoulou A, Skevaki C, Eleutherakis-Papaiakovou E, Pamboucas C, Psimenou E, et al. Clinical and prognostic significance of serum levels of von Willebrand factor and ADAMTS-13 antigens in AL amyloidosis. Blood [Internet]. 2016;128(3):405 - 409. WebsiteAbstract
Cardiac dysfunction determines prognosis in amyloid light-chain (AL) amyloidosis. The heart is the central organ of the vascular system in which endothelium function is critical for the circulatory homeostasis, but there are limited data on endothelial function in AL amyloidosis. von Willebrand factor (VWF) has been considered as a marker of endothelial activation and dysfunction, whereas a disintegrin and metalloproteinase with thrombospondin type-1 repeats 13 (ADAMTS-13) cleaves VWF multimers, but both have been associated with prognosis in cardiovascular disease. We measured the serum levels of VWF (VWF:Ag) and ADAMTS-13 antigens in 111 newly diagnosed patients with AL amyloidosis. The levels of VWF:Ag were significantly higher than in healthy controls; 76% of patients with AL had VWF:Ag levels higher than the upper levels of controls. There was no significant association of VWF:Ag levels with patterns of organ involvement, free light-chain levels, the levels of cardiac biomarkers, or renal dysfunction but correlated with low systolic blood pressure. VWF:Ag levels ≥230.0 U/dL were associated with higher probability of early death and poor survival independently of cardiac biomarkers and low systolic blood pressure (SBP). Moreover, among patients with Mayo stage III or stage IIIB (that is stage III with N-terminal pro-brain natriuretic peptide [NTproBNP] >8500 pg/mL) disease, VWF:Ag identified subgroups of patients with very poor outcome. Low ADAMTS-13 levels correlated with high levels of NTproBNP but had no independent prognostic significance. In conclusion, high VWF:Ag levels, probably representing endothelial dysfunction, are associated with prognosis in patients with AL amyloidosis, independently of other features of the disease or cardiac biomarkers. © 2016 by The American Society of Hematology.
Kastritis E, Papassotiriou I, Terpos E, Roussou M, Gavriatopoulou M, Komitopoulou A, Skevaki C, Eleutherakis-Papaiakovou E, Pamboucas C, Psimenou E, et al. Clinical and prognostic significance of serum levels of von Willebrand factor and ADAMTS-13 antigens in AL amyloidosis. Blood [Internet]. 2016;128(3):405 - 409. WebsiteAbstract
Cardiac dysfunction determines prognosis in amyloid light-chain (AL) amyloidosis. The heart is the central organ of the vascular system in which endothelium function is critical for the circulatory homeostasis, but there are limited data on endothelial function in AL amyloidosis. von Willebrand factor (VWF) has been considered as a marker of endothelial activation and dysfunction, whereas a disintegrin and metalloproteinase with thrombospondin type-1 repeats 13 (ADAMTS-13) cleaves VWF multimers, but both have been associated with prognosis in cardiovascular disease. We measured the serum levels of VWF (VWF:Ag) and ADAMTS-13 antigens in 111 newly diagnosed patients with AL amyloidosis. The levels of VWF:Ag were significantly higher than in healthy controls; 76% of patients with AL had VWF:Ag levels higher than the upper levels of controls. There was no significant association of VWF:Ag levels with patterns of organ involvement, free light-chain levels, the levels of cardiac biomarkers, or renal dysfunction but correlated with low systolic blood pressure. VWF:Ag levels ≥230.0 U/dL were associated with higher probability of early death and poor survival independently of cardiac biomarkers and low systolic blood pressure (SBP). Moreover, among patients with Mayo stage III or stage IIIB (that is stage III with N-terminal pro-brain natriuretic peptide [NTproBNP] >8500 pg/mL) disease, VWF:Ag identified subgroups of patients with very poor outcome. Low ADAMTS-13 levels correlated with high levels of NTproBNP but had no independent prognostic significance. In conclusion, high VWF:Ag levels, probably representing endothelial dysfunction, are associated with prognosis in patients with AL amyloidosis, independently of other features of the disease or cardiac biomarkers. © 2016 by The American Society of Hematology.
Sakellariou S, Fragkou P, Levidou G, Gargalionis AN, Piperi C, Dalagiorgou G, Adamopoulos C, Saetta A, Agrogiannis G, Theohari I, et al. Clinical significance of AGE-RAGE axis in colorectal cancer: associations with glyoxalase-I, adiponectin receptor expression and prognosis. BMC Cancer. 2016;16:174.Abstract
BACKGROUND: Advanced glycation end products (AGEs) and their receptor RAGE emerge as important pathogenic contributors in colorectal carcinogenesis. However, their relationship to the detoxification enzyme Glyoxalase (GLO)-I and Adiponectin receptors (AdipoR1, AdipoR2) in colorectal carcinoma (CRC) is currently understudied. In the present study, we investigated the expression levels of the above molecules in CRC compared to adjacent non-tumoral tissue and their potential correlation with clinicopathological characteristics and patients' survival. METHODS: We analyzed the immunohistochemical expression of AGE, RAGE, GLO-1, AdipoR1 and AdipoR2 in 133 primary CRC cases, focusing on GLO-I. The tumour MSI status was further assessed in mucinous carcinomas. Western immunoblotting was employed for validation of immunohistochemical data in normal and tumoral tissues as well in three CRC cell lines. An independent set of 55 patients was also used to validate the results of univariate survival analysis regarding GLO-I. RESULTS: CRC tissue showed higher intensity of both AGE and RAGE expression compared with normal colonic mucosa which was negative for GLO-I in most cases (78 %). Western immunoblotting confirmed AGE, RAGE and GLO-I overexpression in tumoral tissue. GLO-I expression was directly related to RAGE and inversely related to AGE immunolabeling. There was a trend towards higher expression of all markers (except for RAGE) in the subgroup of mucinous carcinomas which, although of borderline significance, seemed to be more prominent for AdipoR1 and AGE. Additionally, AGE, AdipoR1 and Adipo R2 expression was related to tumor grade, whereas GLO-1 and AdipoR1 to T-category. In survival analysis, AdipoR2 and GLO-I overexpression predicted shortened survival in the entire cohort and in early stage cases, an effect which for GLO-I was reproduced in the validation cohort. Moreover, GLO-I emerged as an independent prognosticator of adverse significance in the patients' cohort. CONCLUSIONS: We herein provide novel evidence regarding the possible interactions between the components of AGE-RAGE axis, GLO-I and adiponectin receptors in CRC. AGE and AdipoR1 are possibly involved in colorectal carcinogenesis, whereas AdipoR2 and GLO-I emerged as novel independent prognostic biomarkers of adverse significance for patients with early disease stage. Further studies are warranted to extend our observations and investigate their potential therapeutic significance.
Giaginis C, Alexandrou P, Delladetsima I, Karavokyros I, Danas E, Giagini A, Patsouris E, Theocharis S. Clinical Significance of Hu-Antigen Receptor (HuR) and Cyclooxygenase-2 (COX-2) Expression in Human Malignant and Benign Thyroid Lesions. Pathol Oncol Res. 2016;22(1):189-96.Abstract
Hu-antigen R (HuR) is considered to play a crucial role in tumor formation and growth by binding to mRNAs encoding proteins such as Cyclooxygenase-2 (COX-2) and inducing their expression via mRNA stabilization and/or altered translation. The present study aimed to evaluate the clinical significance of HuR and COX-2 proteins’ expression in human benign and malignant thyroid lesions. HuR and COX-2 proteins’ expression was assessed immunohistochemically on paraffin-embedded thyroid tissues obtained from 98 patients with benign (n = 48) and malignant (n = 50) lesions and was statistically analyzed with clinicopathological parameters, follicular cells’ proliferative capacity and recurrence risk rate. Enhanced HuR and COX-2 expression was significantly more frequently observed in malignant compared to benign thyroid lesions (p = 0.0073 and p = 0.0016, respectively), as well as in papillary carcinomas compared to hyperplastic nodules (p = 0.0039 and p = 0.0009, respectively). Positive associations of both HuR and COX-2 expression with follicular cells’ proliferation rate were also noted (p = 0.0087 and p = 0.0127, respectively). In malignant thyroid lesions, elevated COX-2 expression was significantly associated with female patients’ gender (p = 0.0381) and the presence of lymph node metastases (p = 0.0296). The present data support evidence that both HuR and COX-2 may be involved in the malignant state of thyroid neoplasia and may be utilized in the diagnosis of malignant thyroid tumors.
Matsangouras IT, Nastos PT, Kapsomenakis J. Cloud-to-ground lightning activity over Greece: Spatio-temporal analysis and impacts. Atmospheric Research [Internet]. 2016;169:485-496. Website
Hermans LE, Svicher V, Pas SD, Salpini R, Alvarez M, Ben Ari Z, Boland G, Bruzzone B, Coppola N, Seguin-Devaux C, et al. Combined Analysis of the Prevalence of Drug-Resistant Hepatitis B Virus in Antiviral Therapy-Experienced Patients in Europe (CAPRE). J Infect Dis. 2016;213(1):39-48.Abstract
BACKGROUND: European guidelines recommend treatment of chronic hepatitis B virus infection (CHB) with the nucleos(t)ide analogs (NAs) entecavir or tenofovir. However, many European CHB patients have been exposed to other NAs, which are associated with therapy failure and resistance. The CAPRE study was performed to gain insight in prevalence and characteristics of NA resistance in Europe. METHODS: A survey was performed on genotypic resistance testing results acquired during routine monitoring of CHB patients with detectable serum hepatitis B virus DNA in European tertiary referral centers. RESULTS: Data from 1568 patients were included. The majority (73.8%) were exposed to lamivudine monotherapy. Drug-resistant strains were detected in 52.7%. The most frequently encountered primary mutation was M204V/I (48.7%), followed by A181T/V (3.8%) and N236T (2.6%). In patients exposed to entecavir (n = 102), full resistance was present in 35.3%. Independent risk factors for resistance were age, viral load, and lamivudine exposure (P < .001). CONCLUSIONS: These findings support resistance testing in cases of apparent NA therapy failure. This survey highlights the impact of exposure to lamivudine and adefovir on development of drug resistance and cross-resistance. Continued use of these NAs needs to be reconsidered at a pan-European level.
Politi N, Nastos PT, Sfetsos A, Vlachogiannis D, Dalezios NR, Gounaris N, Cardoso MR, Soares MMP. Comparison and Validation of WRF Model Physics Parameterizations Over the Domain of Greece. In: {Karacostas TS, Bais AF, Nastos PT} PERSPECTIVES ON ATMOSPHERIC SCIENCES. {PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS}: {Aristotle Univ Thessaloniki, Sch Phys, Lab Atmospher Phys; Aristotle Univ Thessaloniki, Sch Geol, Dept Meteorol & Climatol; Hellen Meteorol Soc; Mariolopoulos Kanaginis Fdn Environm Sci}; 2016. pp. 55-61.Abstract
{In the present study, the dynamical downscaling technique was applied in the Advanced Weather Research and Forecasting numerical model WRF-ARW, to investigate and validate the performance of different physics parameterizations. The WRF model, was forced by ERA-INTERIM reanalysis data, for a short period of one year (January 2002-December 2002), over the area of the MED-CORDEX domain of 20 km horizontal resolution, downscaled to the domain of Greece with grid spacing of 5 km. Simulations with the Yonsei University (YSU) and Mellor-Yamada- Janjic (MYJ) schemes for boundary layer parameterizations were chosen, along with the corresponding surface layer schemes, as well as, cumulus physics schemes of Kain-Fitsch and Grell-Devenyi. The results of the model simulations have been compared with all available station measurements from the European Climate Assessment and Dataset (ECA&D) for the daily precipitation and 2-m air temperature, through the computation of statistical metrics. The study led to a more reliable choice of physics configurations schemes for the WRF model, in order to simulate future climate model experiments to assess the impact of climate change over the domain of interest.}
Lantzouraki, D.Z. SZPVJP. Comparison of the Antioxidant and Antiradical Activity of Pomegranate (Punica granatum L.) by Ultrasound-Assisted and Classical Extraction. Analytical Letters [Internet]. 2016;49:969-978. Website
Tzetis M, Konstantinidou A, Sofocleous C, Kosma K, Mitrakos A, Tzannatos C, Kitsiou‐Tzeli S. Compound heterozygosity of a paternal submicroscopic deletion and a maternal missense mutation in POR gene: Antley‐bixler syndrome phenotype in three sibling fetuses. Birth Defects Research Part A: Clinical and Molecular Teratology. 2016;106(7):536-541.
Vrontaki E, Melagraki G, Kaffe E, Mavromoustakos T, Kokotos E, Aidinis V, Afantitis A. Computer Aided Drug Design Approaches for Identification of Novel Autotaxin (ATX) Inhibitors. Current Medicinal Chemistry [Internet]. 2016;23(17):1708 - 1724. Website
Lykiardopoulou E-M, Tsampa K, Mertzimekis TJ. Construction and Ion-Beam Characterization of Nuclear Targets. In: Hellenic Nuclear Physics Society; 2016.
Karamitros T, Paraskevis D, Hatzakis A, Psichogiou M, Elefsiniotis I, Hurst T, Geretti A-M, Beloukas A, Frater J, Klenerman P, et al. A contaminant-free assessment of Endogenous Retroviral RNA in human plasma. Sci Rep. 2016;6:33598.Abstract
Endogenous retroviruses (ERVs) comprise 6-8% of the human genome. HERVs are silenced in most normal tissues, up-regulated in stem cells and in placenta but also in cancer and HIV-1 infection. Crucially, there are conflicting reports on detecting HERV RNA in non-cellular clinical samples such as plasma that suggest the study of HERV RNA can be daunting. Indeed, we find that the use of real-time PCR in a quality assured clinical laboratory setting can be sensitive to low-level proviral contamination. We developed a mathematical model for low-level contamination that allowed us to design a laboratory protocol and standard operating procedures for robust measurement of HERV RNA. We focus on one family, HERV-K HML-2 (HK2) that has been most recently active even though they invaded our ancestral genomes almost 30 millions ago. We extensively validated our experimental design on a model cell culture system showing high sensitivity and specificity, totally eliminating the proviral contamination. We then tested 236 plasma samples from patients infected with HIV-1, HCV or HBV and found them to be negative. The study of HERV RNA for human translational studies should be performed with extensively validated protocols and standard operating procedures to control the widespread low-level human DNA contamination.
Vavuranakis M, Kalogeras K, Lavda M, Kolokathis M-A, Papaioannou T, Oikonomou E, Stasinopoulou M, Vrachatis D, Moldovan C, Kariori M, et al. Correlation of CoreValve implantation ‘true cover index’ with short and mid-term aortic regurgitation: A novel index. International Journal of Cardiology [Internet]. 2016;223:482 - 487. Website
Balios D, Thomadakis S, Tsipouri L. Credit rating model development: An ordered analysis based on accounting data. Research in International Business and Finance. 2016;38(C):122-136.Abstract
In this paper we propose and test a methodology for constructing a credit rating model. We follow a polytomous ordered probit analysis leading to the specification of statistically significant credit rating intervals. We test our model with accounting data of Greek listed firms over the years 2004–2013, a period which includes both the pre-crisis growth and the crisis phase of the Greek economy and the stock market. Using the empirically—based rating categories that the model generates endogenously, we observe not only a clear and timely response of ratings to the changing economic environment, but we also obtain significant predictive ability over a period of one, two and three years.
"Crude and Broken Forms in America: Avant-Garde and Modernist Affinities inWinesburg, Ohio". In: Precious McKenzie (ed.) Sherwood Anderson's Winesburg Ohio. Leiden, The Netherlands ; Boston : Brill: Rodopi; 2016.
Kastritis E, Dimopoulos MA. Current therapy guidelines for Waldenstrom's macroglobulinaemia. Best Practice and Research: Clinical Haematology [Internet]. 2016;29(2):194 - 205. WebsiteAbstract
Waldenstrom's macroglobulinaemia (WM) is a B-cell neoplasm in which bone marrow is infiltrated by lymphoplasmacytic cells that secrete monoclonal immunoglobulin M (IgM). More than a decade ago, specific criteria were agreed to define diagnosis and symptomatic disease requiring therapy; however, treatment recommendations change as new options emerge. Treatment decisions consider specific disease characteristics (burden of disease, IgM levels, presence of cytopenias) and patient characteristics (age, comorbidities, toxicity). Recently, the impact of specific mutations (in MYD88 and CXCR4) in response to specific therapies has been reported, and this may affect treatment decisions in the future. Chemo-immunotherapy combinations based on rituximab with cyclophosphamide/dexamethasone, bendamustine or bortezomib/dexamethasone are indicated for most patients. The BTK inhibitor ibrutinib was recently approved for patients with WM, and is a new option for selected newly diagnosed or relapsing patients. New B-cell receptor inhibitors, second-generation proteasome inhibitors and mammalian target of rapamycin inhibitors are promising; however, more data are needed from high-quality clinical trials. © 2016 Elsevier Ltd
Kastritis E, Dimopoulos MA. Current therapy guidelines for Waldenstrom's macroglobulinaemia. Best Practice and Research: Clinical Haematology [Internet]. 2016;29(2):194 - 205. WebsiteAbstract
Waldenstrom's macroglobulinaemia (WM) is a B-cell neoplasm in which bone marrow is infiltrated by lymphoplasmacytic cells that secrete monoclonal immunoglobulin M (IgM). More than a decade ago, specific criteria were agreed to define diagnosis and symptomatic disease requiring therapy; however, treatment recommendations change as new options emerge. Treatment decisions consider specific disease characteristics (burden of disease, IgM levels, presence of cytopenias) and patient characteristics (age, comorbidities, toxicity). Recently, the impact of specific mutations (in MYD88 and CXCR4) in response to specific therapies has been reported, and this may affect treatment decisions in the future. Chemo-immunotherapy combinations based on rituximab with cyclophosphamide/dexamethasone, bendamustine or bortezomib/dexamethasone are indicated for most patients. The BTK inhibitor ibrutinib was recently approved for patients with WM, and is a new option for selected newly diagnosed or relapsing patients. New B-cell receptor inhibitors, second-generation proteasome inhibitors and mammalian target of rapamycin inhibitors are promising; however, more data are needed from high-quality clinical trials. © 2016 Elsevier Ltd
Gavriatopoulou M, Terpos E, Kastritis E, Dimopoulos MA. Current treatments for renal failure due to multiple myeloma. Expert Opinion on Pharmacotherapy [Internet]. 2016;17(16):2165 - 2177. WebsiteAbstract
Introduction: Renal impairment (RI) is one of the most common complication of multiple myeloma (MM). RI is present in almost 20% of MM patients at diagnosis and in 40%-50% of patients during the course of their disease. Areas covered: Biology along with tools for diagnosis and management of RI are reported in this paper. Papers published in PubMed and reported abstracts up to May 2016 were used. Expert opinion: Moderate and severe RI increases the risk of early death; thus rapid intervention and initiation of anti-myeloma treatment is essential and improves renal outcomes in RI patients. Bortezomib and dexamethasone triplet combinations are the current standard of therapy for MM patients with acute kidney injury due to cast nephropathy; they offer high rates of both anti-myeloma response and renal recovery. Thalidomide and lenalidomide may be used in bortezomib refractory patients. In the relapsed/refractory setting additional treatment options such as carfilzomib, pomalidomide and monoclonal antibodies are available; however, there is limited data for their effects on patients with RI. High dose melphalan with autologous stem cell transplantation should be considered in otherwise eligible patients with RI. Finally, high cut-off hemodialysis membranes do not seem to offer significant additive effects on anti-myeloma therapies. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
Gavriatopoulou M, Terpos E, Kastritis E, Dimopoulos MA. Current treatments for renal failure due to multiple myeloma. Expert Opinion on Pharmacotherapy [Internet]. 2016;17(16):2165 - 2177. WebsiteAbstract
Introduction: Renal impairment (RI) is one of the most common complication of multiple myeloma (MM). RI is present in almost 20% of MM patients at diagnosis and in 40%-50% of patients during the course of their disease. Areas covered: Biology along with tools for diagnosis and management of RI are reported in this paper. Papers published in PubMed and reported abstracts up to May 2016 were used. Expert opinion: Moderate and severe RI increases the risk of early death; thus rapid intervention and initiation of anti-myeloma treatment is essential and improves renal outcomes in RI patients. Bortezomib and dexamethasone triplet combinations are the current standard of therapy for MM patients with acute kidney injury due to cast nephropathy; they offer high rates of both anti-myeloma response and renal recovery. Thalidomide and lenalidomide may be used in bortezomib refractory patients. In the relapsed/refractory setting additional treatment options such as carfilzomib, pomalidomide and monoclonal antibodies are available; however, there is limited data for their effects on patients with RI. High dose melphalan with autologous stem cell transplantation should be considered in otherwise eligible patients with RI. Finally, high cut-off hemodialysis membranes do not seem to offer significant additive effects on anti-myeloma therapies. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
Dimitrakopoulos Y, Burnetas AN. Customer equilibrium and optimal strategies in an M/M/1 queue with dynamic service control. European Journal of Operational Research [Internet]. 2016;252:477-486. WebsiteAbstract
We consider the problem of customer equilibrium strategies in an M/M/1 queue under dynamic service control. The service rate switches between a low and a high value depending on system congestion. Arriving customers do not observe the system state at the moment of arrival. We show that due to service rate variation, the customer equilibrium strategy is not generally unique, and derive an upper bound on the number of possible equilibria. For the problem of social welfare optimization, we numerically analyze the relationship between the optimal and equilibrium arrival rates as a function of various parameter values, and assess the level of inefficiency via the price of anarchy measure. We finally derive analytic solutions for the special case where the service rate switch occurs when the queue ceases to be empty. © 2016 Elsevier B.V. All rights reserved.
Sergentanis TN, Kastritis E, Terpos E, Dimopoulos MA, Psaltopoulou T. Cytogenetics and Survival of Multiple Myeloma: Isolated and Combined Effects. Clinical Lymphoma, Myeloma and Leukemia [Internet]. 2016;16(6):335 - 340. WebsiteAbstract
Background A variety of clinical and laboratory prognostic factors for multiple myeloma (MM) have been addressed in published studies. The prognostic significance of cytogenetic abnormalities is also under investigation. Patients and Methods The present study evaluated the potential prognostic role of cytogenetic events and their combinations in terms of overall survival in a large cohort of unselected patients with MM (n = 432). Multivariate Cox regression analysis was performed, adjusting for age, gender, Chronic Kidney Disease Epidemiology Collaboration Kidney Disease: Improving Global Outcomes classification, International Staging System score, Eastern Cooperative Oncology Group performance status, serum lactate dehydrogenase, serum calcium, platelet count, and blood hemoglobin. Results The presence of del(13q) (adjusted hazard ratio [HR], 1.71; 95% confidence interval [CI], 1.18-2.47), t(4;14) (adjusted HR, 2.00; 95% CI, 1.19-3.35), and/or del(17p) (adjusted HR, 2.03; 95% CI, 1.22-3.37) was independently associated with poorer overall survival. The poor prognosis seemed more pronounced among patients harboring combinations of 2 adverse cytogenetic abnormalities. In contrast, t(14;16), t(11;14), and add(1q21) were not associated with overall survival. The effect of bortezomib seemed rather minimal in the modification of the prognostic role mediated by del(17p). Conclusion The presence of del(13q), t(4;14), and del(17p), singly or in combination, seems to be an independent poor prognostic factor for patients with MM. © 2016 Elsevier Inc.
Sergentanis TN, Kastritis E, Terpos E, Dimopoulos MA, Psaltopoulou T. Cytogenetics and Survival of Multiple Myeloma: Isolated and Combined Effects. Clinical Lymphoma, Myeloma and Leukemia [Internet]. 2016;16(6):335 - 340. WebsiteAbstract
Background A variety of clinical and laboratory prognostic factors for multiple myeloma (MM) have been addressed in published studies. The prognostic significance of cytogenetic abnormalities is also under investigation. Patients and Methods The present study evaluated the potential prognostic role of cytogenetic events and their combinations in terms of overall survival in a large cohort of unselected patients with MM (n = 432). Multivariate Cox regression analysis was performed, adjusting for age, gender, Chronic Kidney Disease Epidemiology Collaboration Kidney Disease: Improving Global Outcomes classification, International Staging System score, Eastern Cooperative Oncology Group performance status, serum lactate dehydrogenase, serum calcium, platelet count, and blood hemoglobin. Results The presence of del(13q) (adjusted hazard ratio [HR], 1.71; 95% confidence interval [CI], 1.18-2.47), t(4;14) (adjusted HR, 2.00; 95% CI, 1.19-3.35), and/or del(17p) (adjusted HR, 2.03; 95% CI, 1.22-3.37) was independently associated with poorer overall survival. The poor prognosis seemed more pronounced among patients harboring combinations of 2 adverse cytogenetic abnormalities. In contrast, t(14;16), t(11;14), and add(1q21) were not associated with overall survival. The effect of bortezomib seemed rather minimal in the modification of the prognostic role mediated by del(17p). Conclusion The presence of del(13q), t(4;14), and del(17p), singly or in combination, seems to be an independent poor prognostic factor for patients with MM. © 2016 Elsevier Inc.
Samara P, Skopeliti M, Tsiatas ML, Georgaki S, Gouloumis C, Voelter W, Dimopoulos A-M, Bamias A, Tsitsilonis OE. A Cytokine cocktail augments the efficacy of adoptive NK-92 cell therapy against mouse xenografts of human cancer. Anticancer Research [Internet]. 2016;36(7):3373 - 3382. WebsiteAbstract
Background/Aim: Peripheral blood mononuclear cells (PBMCs) activated with immobilized monoclonal antibody against cluster of differentiation 3 (CD3) secrete cytokines in their culture supernatant (termed ACD3S). We examined the antitumor efficacy of ACD3S-activated NK-92 cells in vitro and in vivo. Materials and Methods: Interleukin (IL) 2-depleted NK-92 cells were reactivated with ACD3S, analyzed for their phenotype and tested for cytotoxicity, and perforin and interferon (IFN) production. Severe combined immunodeficient (SCID) mice xenografted with human melanoma and breast cancer cells were treated with ACD3S-activated NK-92 cells and tumor growth was monitored. Results: Brief activation of IL2-depleted NK-92 cells with ACD3S fully restored their in vitro cytotoxicity towards tumor cells. ACD3S-activated NK-92 cells were phenotypically similar to standard NK-92 cells, but exhibited prolonged cytotoxicity and produced higher levels of IFN. When adoptively transferred to tumor-bearing SCID mice, these cells retarded the growth of melanoma and breast tumors. Conclusion: Stimulation of NK-92 cells with ACD3S may be useful in clinical cancer therapy, as an alternative method for ex vivo natural killer cell activation.
Dimopoulos MA, Oriol A, Nahi H, San-Miguel J, Bahlis NJ, Usmani SZ, Rabin N, Orlowski RZ, Komarnicki M, Suzuki K, et al. Daratumumab, lenalidomide, and dexamethasone for multiple myeloma. New England Journal of Medicine [Internet]. 2016;375(14):1319 - 1331. WebsiteAbstract
BACKGROUND: Daratumumab showed promising efficacy alone and with lenalidomide and dexamethasone in a phase 1-2 study involving patients with relapsed or refractory multiple myeloma. METHODS: In this phase 3 trial, we randomly assigned 569 patients with multiple myeloma who had received one or more previous lines of therapy to receive lenalidomide and dexamethasone either alone (control group) or in combination with daratumumab (daratumumab group). The primary end point was progression-free survival. RESULTS: At a median follow-up of 13.5 months in a protocol-specified interim analysis, 169 events of disease progression or death were observed (in 53 of 286 patients [18.5%] in the daratumumab group vs. 116 of 283 [41.0%] in the control group; hazard ratio, 0.37; 95% confidence interval [CI], 0.27 to 0.52; P<0.001 by stratified log-rank test). The Kaplan- Meier rate of progression-free survival at 12 months was 83.2% (95% CI, 78.3 to 87.2) in the daratumumab group, as compared with 60.1% (95% CI, 54.0 to 65.7) in the control group. A significantly higher rate of overall response was observed in the daratumumab group than in the control group (92.9% vs. 76.4%, P<0.001), as was a higher rate of complete response or better (43.1% vs. 19.2%, P<0.001). In the daratumumab group, 22.4% of the patients had results below the threshold for minimal residual disease (1 tumor cell per 105 white cells), as compared with 4.6% of those in the control group (P<0.001); results below the threshold for minimal residual disease were associated with improved outcomes. The most common adverse events of grade 3 or 4 during treatment were neutropenia (in 51.9% of the patients in the daratumumab group vs. 37.0% of those in the control group), thrombocytopenia (in 12.7% vs. 13.5%), and anemia (in 12.4% vs. 19.6%). Daratumumab-associated infusion-related reactions occurred in 47.7% of the patients and were mostly of grade 1 or 2. CONCLUSIONS: The addition of daratumumab to lenalidomide and dexamethasone significantly lengthened progression-free survival among patients with relapsed or refractory multiple myeloma. Daratumumab was associated with infusion-related reactions and a higher rate of neutropenia than the control therapy. Copyright © 2016 Massachusetts Medical Society. All rights reserved.
Dimopoulos MA, Oriol A, Nahi H, San-Miguel J, Bahlis NJ, Usmani SZ, Rabin N, Orlowski RZ, Komarnicki M, Suzuki K, et al. Daratumumab, lenalidomide, and dexamethasone for multiple myeloma. New England Journal of Medicine [Internet]. 2016;375(14):1319 - 1331. WebsiteAbstract
BACKGROUND: Daratumumab showed promising efficacy alone and with lenalidomide and dexamethasone in a phase 1-2 study involving patients with relapsed or refractory multiple myeloma. METHODS: In this phase 3 trial, we randomly assigned 569 patients with multiple myeloma who had received one or more previous lines of therapy to receive lenalidomide and dexamethasone either alone (control group) or in combination with daratumumab (daratumumab group). The primary end point was progression-free survival. RESULTS: At a median follow-up of 13.5 months in a protocol-specified interim analysis, 169 events of disease progression or death were observed (in 53 of 286 patients [18.5%] in the daratumumab group vs. 116 of 283 [41.0%] in the control group; hazard ratio, 0.37; 95% confidence interval [CI], 0.27 to 0.52; P<0.001 by stratified log-rank test). The Kaplan- Meier rate of progression-free survival at 12 months was 83.2% (95% CI, 78.3 to 87.2) in the daratumumab group, as compared with 60.1% (95% CI, 54.0 to 65.7) in the control group. A significantly higher rate of overall response was observed in the daratumumab group than in the control group (92.9% vs. 76.4%, P<0.001), as was a higher rate of complete response or better (43.1% vs. 19.2%, P<0.001). In the daratumumab group, 22.4% of the patients had results below the threshold for minimal residual disease (1 tumor cell per 105 white cells), as compared with 4.6% of those in the control group (P<0.001); results below the threshold for minimal residual disease were associated with improved outcomes. The most common adverse events of grade 3 or 4 during treatment were neutropenia (in 51.9% of the patients in the daratumumab group vs. 37.0% of those in the control group), thrombocytopenia (in 12.7% vs. 13.5%), and anemia (in 12.4% vs. 19.6%). Daratumumab-associated infusion-related reactions occurred in 47.7% of the patients and were mostly of grade 1 or 2. CONCLUSIONS: The addition of daratumumab to lenalidomide and dexamethasone significantly lengthened progression-free survival among patients with relapsed or refractory multiple myeloma. Daratumumab was associated with infusion-related reactions and a higher rate of neutropenia than the control therapy. Copyright © 2016 Massachusetts Medical Society. All rights reserved.
Kontogianni VG, Tsoumani ME, Kellici TF, Mavromoustakos T, Gerothanassis IP, Tselepis AD, Tzakos AG. Deconvoluting the dual antiplatelet activity of a plant extract. Journal of Agricultural and Food Chemistry [Internet]. 2016;64(22):4511 - 4521. Website
Lougiakis N, Gavriil E-S, Kairis M, Sioupouli G, Lambrinidis G, Benaki D, Krypotou E, Mikros E, Marakos P, Pouli N, et al. Design and synthesis of purine analogues as highly specific ligands for FcyB, a ubiquitous fungal nucleobase transporter. Bioorg Med Chem. 2016.Abstract
In the course of our study on fungal purine transporters, a number of new 3-deazapurine analogues have been rationally designed, based on the interaction of purine substrates with the Aspergillus nidulans FcyB carrier, and synthesized following an effective synthetic procedure. Certain derivatives have been found to specifically inhibit FcyB-mediated [(3)H]-adenine uptake. Molecular simulations have been performed, suggesting that all active compounds interact with FcyB through the formation of hydrogen bonds with Asn163, while the insertion of hydrophobic fragments at position 9 and N6 of 3-deazaadenine enhanced the inhibition.
Mertzimekis TJ. Development of a dedicated online database for nuclear moments data. INDC(NDS)-0704. 2016.
Vasilakaki S, Barbayianni E, Leonis G, Papadopoulos MG, Mavromoustakos T, Gelb MH, Kokotos G. Development of a potent 2-oxoamide inhibitor of secreted phospholipase A2 guided by molecular docking calculations and molecular dynamics simulations. Bioorganic and Medicinal Chemistry [Internet]. 2016;24(8):1683 - 1695. Website
Hloupis G, Leoussis C, Pagounis V, Tsakiri M, Vassilakis E, Zacharis V. Development of a Wireless Sensor Network System as basis for Early Warning in Slope Monitoring of the Corinth Canal. In: 3rd Joint International Symposium on Deformation Monitoring (JISDM). Vienna; 2016. pdfAbstract
Corinth Canal is an important technical construction with a significant role in marine and land transportation for Greece. Whilst the main highway of the Corinth bridge is well monitored there is no similar monitoring scheme for landslide failures of the canal walls. This work presents an in-house developed real-time early warning landslide triggering system using wireless sensor network (WSN) nodes. Specifically, for the detection of different types of landslide processes (drift, slide and fall) a set of corresponding MEMS (Micro-Electro-Mechanical Systems) sensors (accelerometer, inclinometer, magnetometer) will be used. These sensors along with radio transmission unit and microprocessor comprise a WSN node. The option for in-situ processing (i.e transmitting only alerts) is possible in order to decrease the communication costs. In conjunction with the proposed WSN system, high accuracy geodetic techniques are used with terrestrial laser scanning (TLS) measurements. TLS is augmenting the point-based system to a spatial -based monitoring system. The paper describes the use of WSN node as triggering device in order to alert the users to begin TLS measurements. A description of the network topology is given along with the implementation of the system in selected control points on the canal walls. Real results are shown and the performance of the system is discussed.
Trachana S-P, Pilalis E, Gavalas NG, Tzannis K, Papadodima O, Liontos M, Rodolakis A, Vlachos G, Thomakos N, Haidopoulos D, et al. The development of an angiogenic protein "signature" in ovarian cancer ascites as a tool for biologic and prognostic profiling. PLoS ONE [Internet]. 2016;11(6). WebsiteAbstract
Advanced ovarian cancer (AOC) is one of the leading lethal gynecological cancers in developed countries. Based on the important role of angiogenesis in ovarian cancer oncogenesis and expansion, we hypothesized that the development of an "angiogenic signature" might be helpful in prediction of prognosis and efficacy of anti-angiogenic therapies in this disease. Sixty-nine samples of ascitic fluid- 35 from platinum sensitive and 34 from platinum resistant patients managed with cytoreductive surgery and 1st-line carboplatin-based chemotherapy- were analyzed using the Proteome Profiler™ Human Angiogenesis Array Kit, screening for the presence of 55 soluble angiogenesis-related factors. A protein profile based on the expression of a subset of 25 factors could accurately separate resistant from sensitive patients with a success rate of approximately 90%. The protein profile corresponding to the "sensitive" subset was associated with significantly longer PFS (8 [95% Confidence Interval {CI}: 8-9] vs. 20 months [95% CI: 15-28]; Hazard ratio {HR}: 8.3, p<0.001) and OS (20.5 months [95% CI: 13.5-30] vs. 74 months [95% CI: 36-not reached]; HR: 5.6 [95% CI: 2.8-11.2]; p<0.001). This prognostic performance was superior to that of stage, histology and residual disease after cytoreductive surgery and the levels of vascular endothelial growth factor (VEGF) in ascites. In conclusion, we developed an "angiogenic signature" for patients with AOC, which can be used, after appropriate validation, as a prognostic marker and a tool for selection for anti-angiogenic therapies. © 2016 Trachana et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Trachana S-P, Pilalis E, Gavalas NG, Tzannis K, Papadodima O, Liontos M, Rodolakis A, Vlachos G, Thomakos N, Haidopoulos D, et al. The development of an angiogenic protein "signature" in ovarian cancer ascites as a tool for biologic and prognostic profiling. PLoS ONE [Internet]. 2016;11(6). WebsiteAbstract
Advanced ovarian cancer (AOC) is one of the leading lethal gynecological cancers in developed countries. Based on the important role of angiogenesis in ovarian cancer oncogenesis and expansion, we hypothesized that the development of an "angiogenic signature" might be helpful in prediction of prognosis and efficacy of anti-angiogenic therapies in this disease. Sixty-nine samples of ascitic fluid- 35 from platinum sensitive and 34 from platinum resistant patients managed with cytoreductive surgery and 1st-line carboplatin-based chemotherapy- were analyzed using the Proteome Profiler™ Human Angiogenesis Array Kit, screening for the presence of 55 soluble angiogenesis-related factors. A protein profile based on the expression of a subset of 25 factors could accurately separate resistant from sensitive patients with a success rate of approximately 90%. The protein profile corresponding to the "sensitive" subset was associated with significantly longer PFS (8 [95% Confidence Interval {CI}: 8-9] vs. 20 months [95% CI: 15-28]; Hazard ratio {HR}: 8.3, p<0.001) and OS (20.5 months [95% CI: 13.5-30] vs. 74 months [95% CI: 36-not reached]; HR: 5.6 [95% CI: 2.8-11.2]; p<0.001). This prognostic performance was superior to that of stage, histology and residual disease after cytoreductive surgery and the levels of vascular endothelial growth factor (VEGF) in ascites. In conclusion, we developed an "angiogenic signature" for patients with AOC, which can be used, after appropriate validation, as a prognostic marker and a tool for selection for anti-angiogenic therapies. © 2016 Trachana et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Karavokyros I, Angelou A, Pikoulis E. The devil hides in the details. Int J Surg. 2016;30:175.
Papaioannou TG, Vlachopoulos C, Tousoulis D. Disassociation of aortic pulse wave velocity and augmentation index in patients with metabolic syndrome: should we blame inflammation?. Blood Pressure [Internet]. 2016;25(3):196 - 197. Website
Diallinas G. Dissection of Transporter Function: From Genetics to Structure. Trends Genet. 2016.Abstract
Transporters are transmembrane proteins mediating the selective uptake or efflux of solutes, metabolites, drugs, or ions across cellular membranes. Despite their immense biological importance in cell nutrition, communication, signaling, and homeostasis, their study remains technically difficult mostly due to their lipid-embedded nature. The study of eukaryotic transporters presents additional complexity due to multiple subcellular control mechanisms that operate to ensure proper membrane traffic, membrane localization, and turnover. Model fungi present unique genetic tools to study eukaryotic transporter function. This review highlights how fungal transporter genetics combined with new methodologies for assaying their cellular expression and function as well as recent structural approaches have led to the functional dissection of selected transporter paradigms in Aspergillus nidulans.
Arabatzis T.
The Structure of Scientific Revolutions and History and Philosophy of Science in Historical Perspective.
In: A. Blum, K. Gavroglu, C. Joas, and J. Renn (eds.), Shifting Paradigms: Thomas S. Kuhn and the History of Science. Berlin: Edition Open Access, Max Planck Institute for the History of Science; 2016. pp. 191-201. 2016a.pdf
Nega AD, Pefkianakis EK, Vougioukalakis GC, Glynos E, Sakellariou G.
Synthesis of P3HT-b-PS donor-acceptor diblock copolymer carrying pendant fullerenes at precise positions along the PS block.
 
. European Polymer Journal [Internet]. 2016;83:148-160.
We present a strategy for the synthesis of a well-defined rod-coil block copolymers of regioregular poly(3hexylthiophene) and polystyrene (P3HT-b-PS), carrying pendant fullerenes (C60) at precise positions along the PS block. The synthesis is achieved by combining ‘living’ anionic polymerization, Kumada catalyst-transfer polycondensation, and click chemistry. Azide terminated polystyrene was synthesized via anionic polymerization, while C60 moieties were grafted along the coil block with a [4+2] Diels-Alder cycloaddition reaction. The regioregular poly(3-hexylthiophene) rod donor block was end-capped with alkyne and was coupled with the azide terminated polystyrene via a copper catalyzed alkyne-azide cycloaddition. Size exclusion chromatography (SEC), NMR, and FTIR spectroscopies were employed to confirm the synthesis of the diblock copolymers. Furthermore, the end-capping of the ‘living’ polystyrene (PS) with the diphenylethylene cyclobutene (DPE-CB) end-group was confirmed by matrixassisted laser desorption/ionization time-of-flight mass spectroscopy (MALDI-TOF MS). Thermogravimetric analysis (TGA) was employed for the estimation of the C60 content in the block copolymer. The C60 content at the coil block was 22 wt% and a strong quenching of photoluminescence (PL) was observed as the result of the aggregation and percolation structure of the C60 within the PS phase. This behavior indicates that the bonding of C60 across the PS block may offer new routes to engineering stable morphologies, where the degree of aggregation/crystallization of the acceptor material is of paramount importance for stable and efficient electron transport.
Κουκουνάρας- Λιάγκης Μάριος.
Teaching Religious Education in Schools and Adolescents’ Social and Emotional Development. An Action Research on the Role of Religious Education and School Community in Adolescents’ Lives
. Cultural and Religious Studies. 2016;4(2):121-133. teaching_religious_education_in_schools.pdf
Liontos M, Anastasiou I, Bamias A, Dimopoulos M-A. DNA damage, tumor mutational load and their impact on immune responses against cancer. Annals of Translational Medicine [Internet]. 2016;4(14). WebsiteAbstract
Advances in immunotherapy have changed the therapeutic landscape in many malignancies. Immune checkpoint inhibitors have already received regulatory approval in melanomas, lung, renal and bladder carcinomas. A common feature of these neoplasms is the increased mutational load, related to a possible increase number of tumor neoantigens that are recognized by the immune system. The mechanisms that DNA damage could confer to the mutational load and the formation of neoantigens and how this could be exploited to advance our immunotherapeutic strategies is discussed in this review. © Annals of Translational Medicine.
Liontos M, Anastasiou I, Bamias A, Dimopoulos M-A. DNA damage, tumor mutational load and their impact on immune responses against cancer. Annals of Translational Medicine [Internet]. 2016;4(14). WebsiteAbstract
Advances in immunotherapy have changed the therapeutic landscape in many malignancies. Immune checkpoint inhibitors have already received regulatory approval in melanomas, lung, renal and bladder carcinomas. A common feature of these neoplasms is the increased mutational load, related to a possible increase number of tumor neoantigens that are recognized by the immune system. The mechanisms that DNA damage could confer to the mutational load and the formation of neoantigens and how this could be exploited to advance our immunotherapeutic strategies is discussed in this review. © Annals of Translational Medicine.
Gkotzamanidou M, Terpos E, Bamia C, Munshi NC, Dimopoulos MA, Souliotis VL. DNA repair of myeloma plasma cells correlates with clinical outcome: The effect of the nonhomologous end-joining inhibitor SCR7. Blood [Internet]. 2016;128(9):1214 - 1225. WebsiteAbstract
DNA repair activity of malignant cells seems to influence therapeutic outcome and patients' survival. Herein, we investigated the mechanistic basis for the link between DNA repair efficiency and response to antimyeloma therapy. Nucleotide excision repair (NER), interstrand cross-links repair (ICL/R), double-strand breaks repair (DSB/R), and chromatin structure were evaluated in multiple myeloma (MM) cell lines (melphalan-sensitive RPMI8226; melphalan-resistant LR5) and bone marrow plasma cells (BMPCs) from MM patients who responded (n = 17) or did not respond (n = 9) to subsequent melphalan therapy. The effect of DSB/R inhibition was also evaluated. Responders' BMPCs showed slower rates of NER and DSB/R (P < .0022), similar rates of ICL/R, and more condensed chromatin structure compared with nonresponders. Moreover, apoptosis rates of BMPCs were inversely correlated with individual DNA repair efficiency and were higher in responders' cells compared with those of nonresponders (P = .0011). Similarly, RPMI8226 cells showed slower rates of NER and DSB/R, comparable rates of ICL/R, more condensed chromatin structure, and higher sensitivity than LR5 cells. Interestingly, cotreatment of BMPCs or cell lines with DSB/R inhibitors significantly reduced the rates ofDSB/R and increasedmelphalan sensitivity of the cells, with the nonhomologous end-joining inhibitor SCR7 showing the strongest effect. Together, responders' BMPCs are characterized by lower efficiencies of NER and DSB/R mechanisms, resulting in higher accumulation of the extremely cytotoxic ICLs andDSBs lesions,which in turn triggers the induction of the apoptotic pathway. Moreover, the enhancement of melphalan cytotoxicity by DSB/R inhibition offers a promising strategy toward improvement of existing antimyeloma regimens. © 2016 by The American Society of Hematology.
Gkotzamanidou M, Terpos E, Bamia C, Munshi NC, Dimopoulos MA, Souliotis VL. DNA repair of myeloma plasma cells correlates with clinical outcome: The effect of the nonhomologous end-joining inhibitor SCR7. Blood [Internet]. 2016;128(9):1214 - 1225. WebsiteAbstract
DNA repair activity of malignant cells seems to influence therapeutic outcome and patients' survival. Herein, we investigated the mechanistic basis for the link between DNA repair efficiency and response to antimyeloma therapy. Nucleotide excision repair (NER), interstrand cross-links repair (ICL/R), double-strand breaks repair (DSB/R), and chromatin structure were evaluated in multiple myeloma (MM) cell lines (melphalan-sensitive RPMI8226; melphalan-resistant LR5) and bone marrow plasma cells (BMPCs) from MM patients who responded (n = 17) or did not respond (n = 9) to subsequent melphalan therapy. The effect of DSB/R inhibition was also evaluated. Responders' BMPCs showed slower rates of NER and DSB/R (P < .0022), similar rates of ICL/R, and more condensed chromatin structure compared with nonresponders. Moreover, apoptosis rates of BMPCs were inversely correlated with individual DNA repair efficiency and were higher in responders' cells compared with those of nonresponders (P = .0011). Similarly, RPMI8226 cells showed slower rates of NER and DSB/R, comparable rates of ICL/R, more condensed chromatin structure, and higher sensitivity than LR5 cells. Interestingly, cotreatment of BMPCs or cell lines with DSB/R inhibitors significantly reduced the rates ofDSB/R and increasedmelphalan sensitivity of the cells, with the nonhomologous end-joining inhibitor SCR7 showing the strongest effect. Together, responders' BMPCs are characterized by lower efficiencies of NER and DSB/R mechanisms, resulting in higher accumulation of the extremely cytotoxic ICLs andDSBs lesions,which in turn triggers the induction of the apoptotic pathway. Moreover, the enhancement of melphalan cytotoxicity by DSB/R inhibition offers a promising strategy toward improvement of existing antimyeloma regimens. © 2016 by The American Society of Hematology.
Vavuranakis M, Siasos G, Zografos T, Oikonomou E, Vrachatis D, Kalogeras K, Papaioannou T, Kolokathis M-A, Moldovan C, Tousoulis D. Dual or single antiplatelet therapy after transcatheter aortic valve implantation? A systematic review and meta-analysis. Current Pharmaceutical Design [Internet]. 2016;22(29):4596 - 4603. Website
Papanikolaou N, Almpanis E, Gantzounis G, Christofi A, Athanasekos L, Stefanou N. Dual photonic-phononic nanocavities for tailoring the acousto-optic interaction. Microelecronic Engineering. 2016;159:80-83.Abstract
We report on the influence of elastic waves on the optical response and light emission in simultaneously photonic and phononic resonant cavities. Elastic waves couple with light through the acousto-optic interaction. Concurrent control of both light and sound through simultaneously photonic–phononic, often called phoxonic, band-gap structures is intended to advance both our understanding as well as our ability to manipulate light with sound and vise versa. In particular, co-localization of light and sound in phoxonic cavities could trigger nonlinear absorption and emission processes and lead to enhanced acousto-optic effects. We review our recent work on sound-controlled optical response and light emission in phoxonic cavities and investigate the limits of validity of the photoelastic model that describes light–sound interaction to first-order approximation. Moreover we present some preliminary results on silicon nitride nanobeam phoxonic devices.
Siasos G, Mourouzis K, Oikonomou E, Vavuranakis M, Vogiatzi G, Briasoulis A, Papageorgiou N, Papaioannou TG, Zografos T, Papapanagiotou A, et al. Duration of dual antiplatelet therapy after coronary stenting. Current Pharmaceutical Design [Internet]. 2016;22(29):4583 - 4595. Website
Kellici TF, Ntountaniotis D, Liapakis G, Tzakos AG, Mavromoustakos T. The dynamic properties of angiotensin II type 1 receptor inverse agonists in solution and in the receptor site. Arabian Journal of Chemistry [Internet]. 2016. Website
Johnson KJ, Glynos E, Sakellariou G, Green P. Dynamics of Star-Shaped Polystyrene Molecules: From Arm Retraction to Cooperativity. Macromolecules [Internet]. 2016;49(15):5669-5676. Publisher's VersionAbstract
The frequency ω dependent storage G′(ω) and loss G″(ω) moduli of star-shaped polystyrene (SPS) molecules of a range of functionalities f and molecular weights per arm Ma were measured under small amplitude oscillatory shear conditions. Star-shaped macromolecules are composed of an inner region, core, where the chain segments are stretched and the “packing” density is higher than that of the outer region, corona. The frequency dependencies of G′(ω) and G″(ω) for low functionality molecules (f<8) with long arms Ma are well described by the model of Milner and McLeish, indicating that the translational dynamics are facilitated by an arm retraction mechanism. With increasing values of f and decreasing Ma the model failsthe arm retraction process is no longer validdue largely to the increasing size of the core in relation to the overall size of the molecule. The molecules exhibit evidence of spatial structural order due to entropic, intermolecular interactions, and the translational dynamics of these molecules occur via a cooperative process, akin to that of soft colloids, for sufficiently large values of f and small Ma. The overall dynamics may be summarized in a diagram delineating different mechanisms that facilitate flow as a function of f and Ma. 
Earth as a life-raft and ethics as the raft's axe
Protopapadakis ED. Earth as a life-raft and ethics as the raft's axe. In: Deretić, Irina / Sorgner, Stefan Lorenz (eds.), From Humanism to Meta-, Post- and Transhumanism? Vol. 8. Beyond Humanism: Trans- and Posthumanism. Frankfurt am Main, Berlin, Bern, Bruxelles, New York, Oxford, Wien: Peter Lang; 2016. pp. 227-241. Publisher's Version
Paraskevis D, Ayouba A, Peeters M. Editorial. Infect Genet Evol. 2016;46:149.
van der Geer, A.A.E., van den Bergh, G.D., Lyras, G.A., Prasetyo, U.W., Awe Due, R., Setiyabudi, E., Drinia, H. The effect of area and isolation on insular dwarf proboscideans. Journal of Biogeography [Internet]. 2016. Publisher's Version
Pagida MA, Konstantinidou AE, Korelidou A, Katsika D, Tsekoura E, Patsouris E, Panayotacopoulou MT. The effect of perinatal hypoxic/ischemic injury on tyrosine hydroxylase expression in the locus coeruleus of the human neonate. Developmental neuroscience. 2016;38(1):41-53.
Stefi AL, Margaritis LH, Christodoulakis NS. The effect of the non ionizing radiation on cultivated plants of Arabidopsis thaliana (Col.). Flora: Morphology, Distribution, Functional Ecology of Plants [Internet]. 2016;223:114 - 120. WebsiteAbstract
A series of experiments was carried out to investigate any structural or biochemical alterations on Arabidopsis thaliana (Col.) plants after a long term exposure to non ionizing radiation emitted from the base unit of a cordless DECT system. Exposed plants, compared to their control counterparts, seem to be affected concerning their biomass and leaf structure. Their leaves are thinner and possess fewer chloroplasts. SEM observations of the exposed leaves reveal that the only feature affected is the pubescence which almost disappears while TEM investigation revealed minor structural effects in the chloroplasts. The reduction in the number of chloroplasts as well as the decrease of stroma thylakoids and photosynthetic pigments are probably the main reasons for a weak photosynthetic potential and a consequent reduction of the biomass production. © 2016 Elsevier GmbH.
Dedes A, Karamitros D, Spanos VC. {Effective Theory for Electroweak Doublet Dark Matter}. Phys. Rev. 2016;D94:095008.
Ververis C, Christodoulakis NS, Santas R, Santas P, Georghiou K. Effects of municipal sludge and treated waste water on biomass yield and fiber properties of kenaf (Hibiscus cannabinus L.). Industrial Crops and Products [Internet]. 2016;84:7 - 12. WebsiteAbstract
Kenaf (Hibiscus cannabinus L.) was experimentally cultivated with the use of digested, dried sewage sludge (130 t/ha) and water from a municipal Sewage Treatment Plant (STP) in order to assess their potential to replace conventional fertilization (100 kg N/ha, 75 kg P2O5/ha and 75 kg Κ2O/ha) and irrigation. Tap water and treated wastewater were used for irrigation in quantities corresponding to 6500 m3/ha. Four different treatment combinations were applied as follows: (a) wastewater irrigation and conventional fertilization, (b) wastewater irrigation and sewage sludge fertilization, (c) tap water irrigation and sewage sludge fertilization, and (d) tap water irrigation and conventional fertilization. The dry plant biomass collected in the final harvest (140 days after plant emergence) from the four treatment plots was 12.3 t/ha, 12.6 t/ha, 12.4 t/ha and 12.8 t/ha respectively. These differences were not statistically significant (ANOVA, P = 0.05) and, therefore, it was concluded that the use of municipal wastes had similar effects on dry biomass production with that of conventional fertilization. An earlier harvest (125 days after plant emergence) gave 11.3% lower dry biomass on average in relation to the second harvest, and this difference was statistically significant (ANOVA, P = 0.05). Premature harvest may lead to significant biomass losses, so the plant must be collected during its technological maturity stage. There was not any statistically significant difference among the four treatments and between the two harvests in fiber dimensions and derived values (suitability indices for paper manufacture). On the other hand, cellulose and lignin content in the second harvest were significantly higher compared to the first one, whereas no significant differences were detected among the four treatments. © 2016 Elsevier B.V.
Nikolaou A, Kokotos G, Magrioti V. Efficient microwave-assisted synthesis of hydroxymethyl ketones using NHC organocatalysts. Tetrahedron. 2016;72:7628-7632.Abstract
Hydroxymethyl ketones are useful auxiliaries in organic synthesis and are also found in several medicinal agents. N-Heterocyclic carbenes (NHCs) have been used in the literature in order to introduce the hydroxymethyl group into aromatic aldehydes in good yields, but they are not that successful for aliphatic aldehydes. In the present work, the use of microwave irradiation has been efficiently incorporated into this organocatalytic synthesis of aromatic, but more importantly of aliphatic hydroxymethyl ketones that can be used as precursors for medicinally interesting compounds.
Kritikou V. El ambiente selvático en Cajambre de Armando Romero. In: Perspectivas de la novela hispanoamericana. Madrid: Ediciones del Orto; 2016. pp. 89-97. el_ambiente_selvatico_en_cajambre_de_armando_romero.1-6.89-97.pdf
Kritikou V. El ámbito geográfico boliviano en Aluvión de Fuego de Óscar Cerruto. In: Europa Balcánica y Los Países de la Cuenca del Mar Negro - Mercosur: Escenarios sociopolíticos, culturales e Integracionistas - Posibilidades y Desafíos. 1st ed. Belgrado: Universidad "John Naisbitt"; 2016. pp. 193-201. el_ambito_geografico_boliviano_en_aluvion_de_fuego_de_oscar_cerruto.197-206.pdf
Kerimis D, Kontos CK, Christodoulou S, Papadopoulos IN, Scorilas A. Elevated expression of miR-24-3p is a potentially adverse prognostic factor in colorectal adenocarcinoma. Clinical Biochemistry. 2016.
Zagouri F, Terpos E, Kastritis E, Dimopoulos MA. Emerging antibodies for the treatment of multiple myeloma. Expert Opinion on Emerging Drugs [Internet]. 2016;21(2):225 - 237. WebsiteAbstract
ABSTRACT: Introduction: Monoclonal antibodies mark the beginning of a new era in the context of multiple myeloma (MM) treatment. Numerous antibodies have been tested or are currently in development for patients with MM, in order to improve tolerability and quality of life. Areas covered: This manuscript reviews emerging antibodies for the treatment of MM i.e. elotuzumab, daratumumab, MOR03087, isatuximab, bevacizumab, cetuximab, siltuximab, tocilizumab, elsilimomab, azintrel, rituximab, tositumomab, milatuzumab, lucatumumab, dacetuzumab, figitumumab, dalotuzumab, AVE1642, tabalumab, pembrolizumab, pidilizumab, nivolumab. Expert opinion: Amongst these antibodies, elotuzumab which targets SLAMF-7 and daratumumab which targets CD38, have been recently approved by FDA for patients with relapsed/refractory MM. Both agents are well tolerated. Multiple clinical trials incorporating these monoclonal antibodies in MM treatment are currently ongoing. Of special interest are the anticipated results of phase III clinical trials with elotuzumab [NCT0189164; NCT01335399; NCT02495922] and daratumumab [NCT02252172; NCT02195479] in newly diagnosed MM patients. Moreover, of great interest are the awaited data on pembrolizumabin combination with pomalidomide and dexamethasone in refractory/relapsed MM patients [NCT02576977] and in combination with lenalidomide and dexamethasone in newly diagnosed MM patients. It seems that the incorporation of monoclonal antibodies will change the landscape of myeloma therapy in the near future. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
Zagouri F, Terpos E, Kastritis E, Dimopoulos MA. Emerging antibodies for the treatment of multiple myeloma. Expert Opinion on Emerging Drugs [Internet]. 2016;21(2):225 - 237. WebsiteAbstract
ABSTRACT: Introduction: Monoclonal antibodies mark the beginning of a new era in the context of multiple myeloma (MM) treatment. Numerous antibodies have been tested or are currently in development for patients with MM, in order to improve tolerability and quality of life. Areas covered: This manuscript reviews emerging antibodies for the treatment of MM i.e. elotuzumab, daratumumab, MOR03087, isatuximab, bevacizumab, cetuximab, siltuximab, tocilizumab, elsilimomab, azintrel, rituximab, tositumomab, milatuzumab, lucatumumab, dacetuzumab, figitumumab, dalotuzumab, AVE1642, tabalumab, pembrolizumab, pidilizumab, nivolumab. Expert opinion: Amongst these antibodies, elotuzumab which targets SLAMF-7 and daratumumab which targets CD38, have been recently approved by FDA for patients with relapsed/refractory MM. Both agents are well tolerated. Multiple clinical trials incorporating these monoclonal antibodies in MM treatment are currently ongoing. Of special interest are the anticipated results of phase III clinical trials with elotuzumab [NCT0189164; NCT01335399; NCT02495922] and daratumumab [NCT02252172; NCT02195479] in newly diagnosed MM patients. Moreover, of great interest are the awaited data on pembrolizumabin combination with pomalidomide and dexamethasone in refractory/relapsed MM patients [NCT02576977] and in combination with lenalidomide and dexamethasone in newly diagnosed MM patients. It seems that the incorporation of monoclonal antibodies will change the landscape of myeloma therapy in the near future. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
Alexakis P, Kenourgios D, Dimitriou D. On emerging stock market contagion: the Baltic region. Research in International Business and Finance [Internet]. 2016;36:312-321. Publisher's VersionAbstract
This study provides new evidence on emerging stock market contagion during the Global Financial crisis (GFC) and the Euro zone Sovereign Debt Crisis (ESDC). Focusing on the three emerging Baltic markets and developed European markets, proxied by the EUROSTOXX50 stock index, we explore asymmetric dynamic conditional correlation dynamics across stable and crisis periods. Empirical evidence indicates a diverse contagion pattern for the Baltic region across the two crises. Latvia and Lithuania were contagious during the GFC, while they were insulated from the adverse effects of the ESDC. On the other hand, Estonia decoupled from the negative consequences during the global turmoil period, but recoupled during the ESDC. The results could be attributed to financial and macroeconomic characteristics of the Baltic countries before and after the turmoil periods and the introduction time of the Euro as a national currency.
Estudios y Homenajes Hispanoamericanos IV. 1st ed. (Pavlakis EP, Symeonidis H, Pajovic S, Drosos DL, Kritikou V). Madrid: Ediciones del Orto; 2016 pp. 458. Publisher's Version
Estudios y Homenajes Hispanoamericanos IV. 1st ed. (Pavlakis EP, Symeonidis H, Pajovic S, Drosos DL, Kritikou V). Madrid: Ediciones del Orto; 2016 pp. 458. Publisher's Version
Pavlakis EP. Nuevas perspectivas en los cuentos de Onelio Jorge Cardoso. 1st ed. Madrid: Ediciones del Orto; 2016.
Kritikou V. Perspectivas de la novela hispanoamericana. 1st ed. Madrid: Ediciones del Orto; 2016 pp. 100.
Varytis P, Pantazopoulos PA, Stefanou N. Enhanced Faraday rotation by crystals of core-shell magnetoplasmonic nanoparticles. Physical Review B. 2016;93(21):214423 (7 pages).Abstract
Collective hybridized plasmon modes, which enable strong magnetooptical coupling and consequent enhanced Faraday effect in three-dimensional periodic assemblies of magnetic dielectric nanoparticles coated with a noble-metal shell, are studied by means of rigorous full electrodynamic calculations using an extension of the layer-multiple-scattering method, in conjunction with the effective-medium approximation. A thorough analysis of relevant photonic dispersion diagrams and transmission spectra provides a consistent explanation of the underlying physical mechanisms to a degree that goes beyond existing interpretation. It is shown that properly designed structures of such composite magnetoplasmonic nanoparticles offer a versatile platform for engineering increased and broadband Faraday rotation.
Papageorgiou F, Godelitsas A, Mertzimekis TJ, Xanthos S, Voulgaris N, Katsantonis G. Environmental impact of phosphogypsum stockpile in remediated Schistos waste site (Piraeus, Greece) using a combination of $\gamma$-ray spectrometry with geographic information systems. Environmental Monitoring and Assessment. 2016;188:1–14.Abstract
From 1979 to 1989, ten million tons of phosphogypsum, a waste by-product of the Greek phosphate fertilizer industry, was disposed into an abandoned limestone quarry in Schistos former waste site, Piraeus (Greece). The quarry has been recently closed and remediated using geomembranes and thick soil cover with vegetation. A part of the deposited phosphogypsum has been exposed due to intense rainfall episodes leading to concerns about how could potentially released radioactivity affect the surrounding environment. This study seeks to assess the environmental impact of the phosphogypsum deposited in the Schistos quarry, using laboratory-based $\gamma$-ray spectrometry measurements and geographical information systems. Radioactivity concentrations were mapped onto spatial-data to yield a spatial-distribution of radioactivity in the area. The data indicate elevated 226Ra concentrations in a specific area on the steep south-eastern cliff of the remediated waste site that comprises uncovered phosphogypsum and is known to be affected by local weather conditions. 226Ra concentrations range from 162 to 629 Bq/kg, with an average activity being on the low side, compared to the global averages for phosphogypsum. Nevertheless, the low environmental risk may be minimized by remediating this area with geomembranes and thick soil cover with vegetation, a technique, which has worked successfully over the remainder of the remediated quarry.
Ntourou K, Moustris KP, Giannouli M, Nastos PT, Paliatsos AG. Estimation of Hospital Admissions Respiratory Disease Attributed to PM10 Exposure Using the AirQ Model Within the Greater Athens Area. In: {Karacostas TS, Bais AF, Nastos PT} PERSPECTIVES ON ATMOSPHERIC SCIENCES. {PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS}: {Aristotle Univ Thessaloniki, Sch Phys, Lab Atmospher Phys; Aristotle Univ Thessaloniki, Sch Geol, Dept Meteorol & Climatol; Hellen Meteorol Soc; Mariolopoulos Kanaginis Fdn Environm Sci}; 2016. pp. 1105-1110.Abstract
{The main objective of this work is the assessment of the annual number of hospital admissions for respiratory disease (HARD) due to the exposure to inhalable particulate matter (PM10), within the greater Athens area (GAA), Greece. Towards this aim, the time series of the particulate matter with aerodynamic diameter less than 10 mu m (PM10) recorded in six monitoring stations located in the GAA, for a 13-year period 2001-2013, is used. In this study AirQ2.2.3 software developed by the WHO, was used to evaluate adverse health effects by PM10 in the GAA during the examined period. The results show that, the mean annual HARD cases per 100,000 inhabitants ranged between 20 (suburban location) and 40 (city centre location). Approximately 70 % of the annual HARD cases are due to city centre residents. In all examined locations, a declining trend in the annual number of HARD cases is appeared. Moreover, a strong relation between the annual number of HARD cases and the annual number of days exceeding the European Union daily PM10 threshold value was found.}
Engert A, Balduini C, Brand A, Coiffier B, Cordonnier C, Döhner H, De Wit TD, Eichinger S, Fibbe W, Green T, et al. The european hematology association roadmap for european hematology research: A consensus document. Haematologica [Internet]. 2016;101(2):115 - 208. WebsiteAbstract
The European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better funded, more focused European hematology research. Initiated by the EHA, around 300 experts contributed to the consensus document, which will help European policy makers, research funders, research organizations, researchers, and patient groups make better informed decisions on hematology research. It also aims to raise public awareness of the burden of blood disorders on European society, which purely in economic terms is estimated at ∈ European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better fu treatments, sometimes in revolutionary ways. This progress highlights the potential of focused basic research programs such as this EHA Roadmap. The EHA Roadmap identifies nine ‘sections’ in hematology: normal hematopoiesis, malignant lymphoid and myeloid diseases, anemias and related diseases, platelet disorders, blood coagulation and hemostatic disorders, transfusion medicine, infections in hematology, and hematopoietic stem cell transplantation. These sections span 60 smaller groups of diseases or disorders. The EHA Roadmap identifies priorities and needs across the field of hematology, including those to develop targeted therapies based on genomic profiling and chemical biology, to eradicate minimal residual malignant disease, and to develop cellular immunotherapies, combination treatments, gene therapies, hematopoietic stem cell treatments, and treatments that are better tolerated by elderly patients. © 2016 Ferrata Storti Foundation.
Nastos PT, Kapsomenakis J, Philandras KM. Evaluation of the TRMM 3B43 gridded precipitation estimates over Greece. Atmospheric Research [Internet]. 2016;169:497-514. Website
Sakelliou A, Fatouros IG, Athanailidis I, Tsoukas D, Chatzinikolaou A, Draganidis D, Jamurtas AZ, Liacos C, Papassotiriou I, Mandalidis D, et al. Evidence of a Redox-Dependent Regulation of Immune Responses to Exercise-Induced Inflammation. Oxidative Medicine and Cellular Longevity [Internet]. 2016;2016. WebsiteAbstract
We used thiol-based antioxidant supplementation (n-acetylcysteine, NAC) to determine whether immune mobilisation following skeletal muscle microtrauma induced by exercise is redox-sensitive in healthy humans. According to a two-trial, double-blind, crossover, repeated measures design, 10 young men received either placebo or NAC (20mg/kg/day) immediately after a muscledamaging exercise protocol (300 eccentric contractions) and for eight consecutive days. Blood sampling and performance assessments were performed before exercise, after exercise, and daily throughout recovery. NAC reduced the decline of reduced glutathione in erythrocytes and the increase of plasma protein carbonyls, serum TAC and erythrocyte oxidized glutathione, and TBARS and catalase activity during recovery thereby altering postexercise redox status. The rise of muscle damage and inflammatory markers (muscle strength, creatine kinase activity, CRP, proinflammatory cytokines, and adhesion molecules) was less pronounced in NAC during the first phase of recovery. The rise of leukocyte and neutrophil count was decreased by NAC after exercise. Results on immune cell subpopulations obtained by flow cytometry indicated that NAC ingestion reduced the exerciseinduced rise of total macrophages, HLA+ macrophages, and 11B+ macrophages and abolished the exercise-induced upregulation of B lymphocytes. Natural killer cells declined only in PLA immediately after exercise. These results indicate that thiol-based antioxidant supplementation blunts immune cell mobilisation in response to exercise-induced inflammation suggesting that leukocyte mobilization may be under redox-dependent regulation. Copyright © 2016 Alexandra Sakelliou et al.
Khaliel A, Mertzimekis TJ, Psaltis A, Psyrra I, Lagaki V, Foteinou V, Axiotis M, Harissopulos S. Experimental Investigation of radiative proton-capture reactions relevant to Nucleosynthesis. In: Hellenic Nuclear Physics Society; 2016.
Kritsi E, Matsoukas M-T, Potamitis C, Karageorgos V, Detsi A, Magafa V, Liapakis G, Mavromoustakos T, Zoumpoulakis P. Exploring new scaffolds for angiotensin II receptor antagonism. Bioorganic and Medicinal Chemistry [Internet]. 2016;24(18):4444 - 4451. Website
Papaioannou D, Peroulis S, Mertzimekis TJ. Exploring the feasibility of magnetic moment measurements in the exotic $^{20}$C nucleus using LISE++ calculations. In: Hellenic Nuclear Physics Society; 2016.
Liontos M, Trigka E-A, Korkolopoulou P, Tzannis K, Lainakis G, Koutsoukos K, Kostouros E, Lykka M, Papandreou CN, Karavasilis V, et al. Expression and prognostic significance of VEGF and mTOR pathway proteins in metastatic renal cell carcinoma patients: a prognostic immunohistochemical profile for kidney cancer patients. World Journal of Urology [Internet]. 2016:1 - 9. WebsiteAbstract
Purpose: To identify prognostic molecular profiles in patients with mRCC treated with sunitinib, we performed immunohistochemical analysis for VEGF and PI3K/Akt/mTOR pathway components. Methods: The immunohistochemical expression of VEGF, p85α, p110γ, PTEN, p-Akt, p-mTOR, p-4E-BP1 and p-p70S6K was studied in 79 patients with mRCC who received first-line treatment with sunitinib. Expression was correlated with clinicopathological features and survival. Results: VEGF was highly expressed (median H-Score 150), while positivity for the markers of the PI3K/Akt/mTOR pathway was: p85α 43/66 (65 %), p110γ41/60 (68 %), PTEN 32/64 (50 %), p-Akt57/63 (90 %), p-mTOR48/64 (75 %), p-4E-BP1 58/64 (90 %) and p-p70S6K 60/65 (92 %). No single immunohistochemical marker was found to have prognostic significance. Instead, the combination of increased p-mTOR and low VEGF expression was adversely correlated with overall survival (OS) (3.2 vs. 16.9 months, P = 0.001). Conclusion: Immunohistochemistry for VEGF and p-mTOR proteins may discriminate patients refractory to first-line sunitinib with poor prognosis. Prospective validation of our findings is needed. © 2016 Springer-Verlag Berlin Heidelberg
Liontos M, Trigka E-A, Korkolopoulou P, Tzannis K, Lainakis G, Koutsoukos K, Kostouros E, Lykka M, Papandreou CN, Karavasilis V, et al. Expression and prognostic significance of VEGF and mTOR pathway proteins in metastatic renal cell carcinoma patients: a prognostic immunohistochemical profile for kidney cancer patients. World Journal of Urology [Internet]. 2016:1 - 9. WebsiteAbstract
Purpose: To identify prognostic molecular profiles in patients with mRCC treated with sunitinib, we performed immunohistochemical analysis for VEGF and PI3K/Akt/mTOR pathway components. Methods: The immunohistochemical expression of VEGF, p85α, p110γ, PTEN, p-Akt, p-mTOR, p-4E-BP1 and p-p70S6K was studied in 79 patients with mRCC who received first-line treatment with sunitinib. Expression was correlated with clinicopathological features and survival. Results: VEGF was highly expressed (median H-Score 150), while positivity for the markers of the PI3K/Akt/mTOR pathway was: p85α 43/66 (65 %), p110γ41/60 (68 %), PTEN 32/64 (50 %), p-Akt57/63 (90 %), p-mTOR48/64 (75 %), p-4E-BP1 58/64 (90 %) and p-p70S6K 60/65 (92 %). No single immunohistochemical marker was found to have prognostic significance. Instead, the combination of increased p-mTOR and low VEGF expression was adversely correlated with overall survival (OS) (3.2 vs. 16.9 months, P = 0.001). Conclusion: Immunohistochemistry for VEGF and p-mTOR proteins may discriminate patients refractory to first-line sunitinib with poor prognosis. Prospective validation of our findings is needed. © 2016 Springer-Verlag Berlin Heidelberg
Drivalos A, Chrisofos M, Efstathiou E, Kapranou A, Kollaitis G, Koutlis G, Antoniou N, Karanastasis D, Dimopoulos MA, Bamias A. Expression of α5-integrin, α7-integrin, Ε-cadherin, and N-cadherin in localized prostate cancer. Urologic Oncology: Seminars and Original Investigations [Internet]. 2016;34(4):165.e11 - 165.e18. WebsiteAbstract
Objective: To explore the correlation between the expression of α5-integrin, α7-integrin, Ε-cadherin, and N-cadherin in prostate cancer (PCa) and its clinicopathological data including tumor grade and clinical stage. Methods: The expression of α5-integrin, α7-integrin, Ε-cadherin, and N-cadherin was examined in 157 cases of PCa and adjacent normal prostatic tissue by immunohistochemical assay, and the correlation with clinicopathological features was analyzed. Results: Expressions of α5-integrin, α7-integrin, and Ε-cadherin in PCa were lower than those in normal prostatic tissues (P<0.05). N-cadherin expression was higher in cancer prostatic tissue than in normal prostatic tissues (P<0.05). The reduced expression of α5-integrin, α7-integrin, and Ε-cadherin was related to Gleason score, pathological stage, lymph node metastasis, and prostate-specific antigen level, but it was not associated with positive surgical margins and patient age. The increased expression of N-cadherin was related to Gleason score, pathological stage, lymph node metastasis, and prostate-specific antigen level, but not to age and positive surgical margins. The expression of E-cadherin was highly negatively correlated with that of N-cadherin and also positively correlated with that of α5-integrin and α7-integrin. Conclusion: The reduced expression of α5-integrin, α7-integrin, and Ε-cadherin and abnormal expression of N-cadherin play an important role in the occurrence and development of PCa. The results indicate that these have potential values in the diagnosis and are predictable indices in the proliferation of PCa. © 2016 Elsevier Inc.
Drivalos A, Chrisofos M, Efstathiou E, Kapranou A, Kollaitis G, Koutlis G, Antoniou N, Karanastasis D, Dimopoulos MA, Bamias A. Expression of α5-integrin, α7-integrin, Ε-cadherin, and N-cadherin in localized prostate cancer. Urologic Oncology: Seminars and Original Investigations [Internet]. 2016;34(4):165.e11 - 165.e18. WebsiteAbstract
Objective: To explore the correlation between the expression of α5-integrin, α7-integrin, Ε-cadherin, and N-cadherin in prostate cancer (PCa) and its clinicopathological data including tumor grade and clinical stage. Methods: The expression of α5-integrin, α7-integrin, Ε-cadherin, and N-cadherin was examined in 157 cases of PCa and adjacent normal prostatic tissue by immunohistochemical assay, and the correlation with clinicopathological features was analyzed. Results: Expressions of α5-integrin, α7-integrin, and Ε-cadherin in PCa were lower than those in normal prostatic tissues (P<0.05). N-cadherin expression was higher in cancer prostatic tissue than in normal prostatic tissues (P<0.05). The reduced expression of α5-integrin, α7-integrin, and Ε-cadherin was related to Gleason score, pathological stage, lymph node metastasis, and prostate-specific antigen level, but it was not associated with positive surgical margins and patient age. The increased expression of N-cadherin was related to Gleason score, pathological stage, lymph node metastasis, and prostate-specific antigen level, but not to age and positive surgical margins. The expression of E-cadherin was highly negatively correlated with that of N-cadherin and also positively correlated with that of α5-integrin and α7-integrin. Conclusion: The reduced expression of α5-integrin, α7-integrin, and Ε-cadherin and abnormal expression of N-cadherin play an important role in the occurrence and development of PCa. The results indicate that these have potential values in the diagnosis and are predictable indices in the proliferation of PCa. © 2016 Elsevier Inc.
Maliverno E, Karatsolis B-T, Dimiza M, Lagaria A, Psarra S, Triantaphyllou M. Extant silicoflagellates from the Northeast Aegean (eastern Mediterranean Sea): Morphologies and double skeletons. Revue de micropaléontologie [Internet]. 2016;59:253–265. Publisher's VersionAbstract
Silicoflagellate abundance, vertical distribution and morphology were studied during spring (March 2014) at three sampling stations locatedin the Northeast Aegean Sea adjacent to the Dardanelles Strait and characterized by a variable influx of cold, low-salinity Black Sea water.The silicoflagellate assemblage was dominated by Dictyocha stapedia and Stephanocha speculum with minor contribution of D. aculeata andOctactis pulchra. While specimens of D. stapedia were represented by the typical morphologies described in other areas of the Mediterranean Sea,populations of S. speculum displayed peculiar characters: they were large, predominantly 7-sided, with a small apical ring as well as apical ringspines, concave basal ring sides and non-rotated apical structure. Some of these features have been described for S. speculum at high latitudes, butthe combined characters make these specimens slightly different from the high latitude populations. Similar morphologies have been observed inthe western Black Sea, thus we can infer that the peculiar specimens detected in the Northeast Aegean are associated with the influx of Black Seawater masses.
Papamarinopoulos S, Preka-Papadema P, Gazeas K, Nastos P, Kiriakopoulos KG. Extreme physical phenomena during the Trojan war. Mediterranean Archaeology and Archaeometry [Internet]. 2016;16:135-155. Website
Dalamaga M, Polyzos SA, Karmaniolas K, Chamberland J, Lekka A, Triantafilli M, Migdalis I, Papadavid E, Mantzoros CS. Fetuin-A levels and free leptin index are reduced in patients with chronic lymphocytic leukemia: a hospital-based case-control study. Leuk Lymphoma. 2016;57(3):577-84.Abstract
There are limited data on fetuin-A, soluble leptin receptor (sOB-R) and free leptin index (FLI) in patients with chronic lymphocytic leukemia (CLL). The aim of this study was to compare circulating fetuin-A, sOB-R levels and FLI between 95 patients with CLL and 95 matched controls, as well as among different stages of CLL. Circulating fetuin-A was significantly lower in cases than controls (241.9 ± 99.2 vs. 288.8 ± 127.7 μg/mL; p = 0.005). Although circulating sOB-R levels were similar between groups, FLI was lower in cases than controls (0.45 ± 0.42 vs. 0.67 ± 0.57; p = 0.003). Furthermore, lower fetuin-A or FLI, but not sOB-R, were independently associated with CLL (p < 0.05), particularly among overweight/obese individuals. Fetuin-A, s-OB-R and FLI were similar between different stages of CLL severity, or between symptomatic and asymptomatic disease. In conclusion, circulating fetuin-A and FLI, but not sOB-R, were lower in patients with CLL than controls, a finding warranting further investigation.
Belasen A, Brock K, Li B, Chremou D, Valakos E, Pafilis P, Sinervo B, Foufopoulos J. Fine with heat, problems with water: Microclimate alters water loss in a thermally adapted insular lizard. Oikos [Internet]. 2016. Website
Dimiza, M., Triantaphyllou, M., Koukousioura, O., Hallock, P., Simboura, N., Karageorgis, A.P., Papathanasiou, E. The Foram Stress Index: A new tool for environmental assessment of soft-bottom environments using benthic foraminifera. A case study from the Saronikos Gulf, Greece, Eastern Mediterranean. Ecological Indicators [Internet]. 2016;60:611-621. Publisher's VersionAbstract
Saronikos Gulf, including the industrial zone of Elefsis Bay and the Port of Piraeus, is one of the most anthropogenically impacted coastal regions of Greece. Distinct assemblages of benthic foraminifers in sediment samples, collected from this gulf in February 2012, defined three zones that reflect abiotic parameters of the sediments (e.g., organic carbon, metal content). A low-diversity assemblage, dominated by stress-tolerantAmmonia tepida and Bulimina spp., was characteristic of samples from Elefsis Bay. Samples from the western and central part of Saronikos Gulf were the most variable with respect to both abiotic parameters and the foraminiferal assemblage, characterized by a mix of stress-tolerant and more sensitive taxa, especially Bolivina spp. andNonion fabum. Samples from the coast of Salamis and at the eastern sector of the gulf were characterized by a diverse assemblage that included Peneroplis pertusus, miliolids, and a variety of small, epiphytic rotaliid taxa. A new biotic index, the Foram Stress Index (FSI), is based on the relative percentages of two ecological groups of benthic foraminiferal species, grouped according to their tolerance/sensitivity to organic matter enrichment and weighted proportionately to obtain a formula to define five ecological-status classes. The FSI produced three rankings for these samples (Poor, Moderate and Good), that strongly correlate with the macroinvertebrate-classification tool known as the BENTIX Index. The FSI provides a new tool to assess sediment or substrata quality based upon the benthic foraminiferal assemblages, which are a significant component of living meiobenthic communities that are generally not considered in most biotic benthic indices.
Dimiza, M., Triantaphyllou, M., Koukousioura, O., Hallock, P., Simboura, N., Karageorgis, A.P., Papathanasiou, E. The Foram Stress Index: A new tool for environmental assessment of soft-bottom environments using benthic foraminifera. A case study from the Saronikos Gulf, Greece, Eastern Mediterranean. Ecological Indicators [Internet]. 2016;60:611-621. Publisher's VersionAbstract
Saronikos Gulf, including the industrial zone of Elefsis Bay and the Port of Piraeus, is one of the most anthropogenically impacted coastal regions of Greece. Distinct assemblages of benthic foraminifers in sediment samples, collected from this gulf in February 2012, defined three zones that reflect abiotic parameters of the sediments (e.g., organic carbon, metal content). A low-diversity assemblage, dominated by stress-tolerantAmmonia tepida and Bulimina spp., was characteristic of samples from Elefsis Bay. Samples from the western and central part of Saronikos Gulf were the most variable with respect to both abiotic parameters and the foraminiferal assemblage, characterized by a mix of stress-tolerant and more sensitive taxa, especially Bolivina spp. andNonion fabum. Samples from the coast of Salamis and at the eastern sector of the gulf were characterized by a diverse assemblage that included Peneroplis pertusus, miliolids, and a variety of small, epiphytic rotaliid taxa. A new biotic index, the Foram Stress Index (FSI), is based on the relative percentages of two ecological groups of benthic foraminiferal species, grouped according to their tolerance/sensitivity to organic matter enrichment and weighted proportionately to obtain a formula to define five ecological-status classes. The FSI produced three rankings for these samples (Poor, Moderate and Good), that strongly correlate with the macroinvertebrate-classification tool known as the BENTIX Index. The FSI provides a new tool to assess sediment or substrata quality based upon the benthic foraminiferal assemblages, which are a significant component of living meiobenthic communities that are generally not considered in most biotic benthic indices.
Drinia, H., Antonarakou, A., Tsourou, T., Kontakiotis, G., Psychogiou, M., Anastasakis, G. Foraminifera eco-biostratigraphy of the southern Evoikos outer shelf, central Aegean Sea, during MIS 5 to present. Continental Shelf Research [Internet]. 2016;126:36-49. Publisher's Version
Georgiopoulos GA, Lambrinoudaki I, Athanasouli F, Armeni E, Rizos D, Kazani M, Karamanou M, Manios E, Augoulea A, Stellos K, et al. Free androgen index as a predictor of blood pressure progression and accelerated vascular aging in menopause. Atherosclerosis. 2016;247:177 - 183.Abstract
© 2016 Elsevier Ireland Ltd. Background and aims: We aimed to assess the prognostic value of free androgen index (FAI) and its change over time in arterial stiffness progression, endothelial function and hypertension in postmenopausal women. Methods: Postmenopausal women (n = 180) without clinically overt cardiovascular disease or diabetes were consecutively recruited and followed for a median of 29 months. The main outcome measures were changes over time in endothelial function (FMD), reflected waves, localized and systemic (PWV) arterial stiffness and hypertension. Results: Increased baseline FAI was significantly associated with new onset hypertension (OR for each SD, 2.71, 95% CI 1.14-6.41, p = 0.024), deterioration of pulse wave velocity (PWV) (0.414 m/s per SD), flow-mediated dilation (FMD) (-0.42% per SD), systolic (2.5 mmHg per SD) and pulse pressure progression (2.3 mmHg per SD, p < 0.05 for all). Baseline FAI remained an independent predictor of changes in PWV (p = 0.006), FMD (p = 0.02), peripheral pulse pressure (p = 0.028), transition to new onset hypertension (p = 0.001) and higher BP category (p = 0.012), after adjustment for age, changes in systolic blood pressure, traditional risk factors, vasoactive medication or total testosterone. Baseline FAI improved reclassification for the risk of transition into higher BP category (NRI = 47.5 ± 20.3%, p = 0.02) and abnormal PWV (NRI = 53.4 ± 23.2%, p = 0.021). Similarly, in a subgroup of patients with measured FAI at follow-up, its changes over time predicted changes in PWV, peripheral pulse pressure and hypertension status (p < 0.05 for all). Conclusions: In apparently healthy postmenopausal women, FAI could be a novel biomarker superior to total testosterone for accelerated vascular aging and hypertension status.
Arabatzis T, Gavroglu K. From Discrepancy to Discovery: How Argon Became an Element. In: T. Sauer & R. Scholl (eds), The Philosophy of Historical Case Studies. Dordrecht: Springer; 2016. pp. 203-222. Publisher's VersionAbstract
In this paper, we revisit the discovery of argon by Lord Rayleigh and William Ramsay. We argue that to understand historically how argon was detected, conceptualized, and accommodated into chemical knowledge we need to take into account the philosophical insight that scientific discovery is often an extended process. One of argon’s most intriguing properties was that it did not react with other elements. Reactivity, however, had been a constitutive property of elements. Thus, the discovery of argon could not have been accepted by chemists without a reconceptualization of ‘element’. Furthermore, there were difficulties with the accommodation of argon in the Periodic table, because argon appeared to undermine the conception of matter that underlay the Periodic table. The discovery of argon was complete only after those conceptual difficulties had been removed. This is why it has to be understood as an extended process, rather than as an event. Furthermore, we will suggest that some of the factors that complicated the discovery of argon were related to the legitimization of physical techniques of investigation in chemistry and the emergence of physical chemistry.
Goulas V, Stylos E, Chatziathanasiadou MV, Mavromoustakos T, Tzakos AG. Functional components of carob fruit: Linking the chemical and biological space. International Journal of Molecular Sciences [Internet]. 2016;17(11). Website
Goulas V, Stylos E, Chatziathanasiadou MV, Mavromoustakos T, Tzakos AG. Functional components of carob fruit: Linking the chemical and biological space. International Journal of Molecular Sciences [Internet]. 2016;17(11). Website
Chrysostomou S. Further Perspectives 2A. In: Oxford Handbook of Technology & Music Education. Oxford: Oxford University Press; 2016.
Kamberidou I. "A Futurist and Hybrid Scientist, the result of a Multidisciplinary Education". Irene Kamberidou interviews Eleni Antoniadou, multidisciplinary scientist in Artificial Organ Technology and President of the European Health Parliament. Interview for 1st European Celebration of Women in Computing (ECWC), Brussels, 25-26 April 2016 (womenincomputing.eu), organized by European European Centre for Women and Technology (ECWT):. 2016.Abstract
When citing:  Kamberidou, Irene (2016).  A Futurist and Hybrid Scientist, the result of a Multidisciplinary Education. Irene Kamberidou interviews Eleni Antoniadou, multidisciplinary scientist in Artificial Organ Technology and President of the European Health Parliament, 04/14/2016 - 12:25:  http://www.womenincomputing.eu/blog/470/futurist-and-hybrid-scientist-result-multidisciplinary-education-irene-kamberidou-ecwt    Interview for  1st European Celebration of Women in Computing (ECWC), Brussels, 25-26 April 2016! (womenincomputing.eu), organized by European European Centre for Women and Technology (ECWT): SPONSORS: http://womenincomputing.eu/sponsors Website: www.ecwt.eu
a_futurist_and_hybrid_scientist.pdf a_futurist_and_hybrid_scientist.pdf
Magiorkinis G, Angelis K, Mamais I, Katzourakis A, Hatzakis A, Albert J, Lawyer G, Hamouda O, Struck D, Vercauteren J, et al. The global spread of HIV-1 subtype B epidemic. Infect Genet Evol. 2016;46:169-179.Abstract
Human immunodeficiency virus type 1 (HIV-1) was discovered in the early 1980s when the virus had already established a pandemic. For at least three decades the epidemic in the Western World has been dominated by subtype B infections, as part of a sub-epidemic that traveled from Africa through Haiti to United States. However, the pattern of the subsequent spread still remains poorly understood. Here we analyze a large dataset of globally representative HIV-1 subtype B strains to map their spread around the world over the last 50years and describe significant spread patterns. We show that subtype B travelled from North America to Western Europe in different occasions, while Central/Eastern Europe remained isolated for the most part of the early epidemic. Looking with more detail in European countries we see that the United Kingdom, France and Switzerland exchanged viral isolates with non-European countries than with European ones. The observed pattern is likely to mirror geopolitical landmarks in the post-World War II era, namely the rise and the fall of the Iron Curtain and the European colonialism. In conclusion, HIV-1 spread through specific migration routes which are consistent with geopolitical factors that affected human activities during the last 50years, such as migration, tourism and trade. Our findings support the argument that epidemic control policies should be global and incorporate political and socioeconomic factors.
Charitaki E, Kastritis E, Petraki C, Liapis K, Adamidis K, Apostolou T, Christodoulidou C, Nikolopoulou N, Terpos E, Nakopoulou L, et al. Glomerular expression of matrix metalloproteinases in AL-amyloidosis and association with renal function at the time of kidney biopsy. Clinical Nephrology [Internet]. 2016;85(1):44 - 52. WebsiteAbstract
Background: Matrix metalloproteinases (MMPs) have been implicated in the pathophysiology of various renal diseases, however, there are limited data regarding their role in renal AL-amyloidosis. In the present study, we evaluated the glomerular expression of MMPs in renal-biopsy specimens containing AL-amyloid deposits. We also examined the association of MMPs with renal function at the time of diagnostic renal biopsy. Methods: We performed immunohistochemistry with monoclonal antibodies against MMP-1, MMP-2, MMP-3, MMP-9, and TIMP-1 in 19 kidney-biopsy specimens with AL-amyloidosis and 8 specimens from normal kidney tissue. We used clinical data of the patients at the time of kidney biopsy to evaluate the association between MMP expression and renal function. Results: We found increased MMP-1 and MMP-3 expression within the amyloid deposits and adjacent tissues in > 50% of the amyloid-positive biopsies, whereas MMP-1 and MMP-3 were negative in control samples. In contrast, we found no significant glomerular MMP-2 and TIMP-1 expression in amyloid-containing or normal kidneys. MMP-9 expression was found in the glomerular basement membrane equally in AL-amyloidosis and control specimens. The presence of MMP-1 and MMP-3 in the glomeruli of patients with AL-amyloidosis correlated with worse renal function at the time of kidney biopsy. Conclusion: The findings of this study show increased glomerular expression of MMP-1 and MMP-3 in patients with AL-amyloidosis which is associated with worse renal function at the time of the kidney biopsy. Our results suggest an important role for MMP-1 and MMP-3 in the pathogenesis of renal damage in AL-amyloidosis. © 2016 Dustri-Verlag Dr. K. Feistle.
Greek Art and Archaeology, 1200-30 BC. Atlanta: Lockwood Press; 2016. Publisher's VersionAbstract
Τhis lavishly illustrated book surveys Greek archaeology from the collapse of the Mycenaean palaces to the subordination of the last Hellenistic kingdoms to Rome. Its aim is to study Greek art through the material record, and against its cultural and social backdrop. The book's target audience is archaeology and art students, as well as anyone interested in Greek art and culture. Through concise, systematic covering of the main categories of classical monuments, the reader is taken to a tour of ancient Greece along the most spectacular period in its history, the 1st millennium BC. Architecture and city planning, sculpture, painting, pottery, metallurgy, jewelry, and numismatics are some of the areas covered.
Kamberidou I, Chroni S. The Greek Experience: Outstanding Women in the Social Space of Sport. In: Inspirational Women in Europe: making a difference in Physical Education, Sport and Dance. Juiz de Fora, Brazil.: Rosa Diketmüller (editor). Juiz de Fora : NGIME/UFJF, 2016. 254 p. (IAPESGW Continent Series). Publication of the International Association of Physical Education and Sport for Girls and Women (IAPESGW), ISBN 978-85-67380-55-1; 2016. pp. 224–242.Abstract
The Voices of Six Inspirational Greek Women in Sport: What inspired them to take that leap; the Obstacles they faced; how they moved forward and Tips for Success.  Many inspirational and outstanding women have made a difference in the lives of girls and women in sport, physical education (PE) and physical activity in Greece, despite their invisibility in the mainstream media, the life stories of which would need volumes. They succeeded in making a difference while respecting and celebrating diversity with regard to gender, ethnicity, culture, disability, age and sexual orientation. Beginning with a brief discussion on the underrepresentation of women’s sports and the female athlete in the Greek media, this chapter shares the contributions of some inspiring and motivating Greek women in sport whose achievements have been excluded from the country’s mainstream media. It is through six in-depth interviews and follow-up meetings that we learn how these pioneers influenced the lives of sporting girls and women by daring to disregard social barriers and spread awareness. We conclude the chapter with tips from these successful, namely inspirational women, who all agree that success requires ethos and taking that leap.http://www.ngime.ufjf.br/wp-content/uploads/Europa_opt.pdf
inspirational_women_in_europe_0330_continentes_europa.pdf book_cover_inspiratoinal_women_in_sport.jpg inspirational_women_hardcopy_sample.pdf inspirational_women_in_europe_making_a_difference_in_phys.ed_.sport_and_dance.pdf
Lambrinoudaki I, Augoulea A, Rizos D, Politi M, Tsoltos N, Moros M, Chinou I, Graikou K, Kouskouni E, Kambani S, et al. Greek-origin royal jelly improves the lipid profile of postmenopausal women. Gynecological Endocrinology [Internet]. 2016:1-5. Website
Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2016;12(1):1-222.
Thodi G, Schulpis KH, Dotsikas Y, Pavlides C, Molou E, Chatzidaki M, Triantafylli O, Loukas YL. Hawkinsinuria in two unrelated Greek newborns: Identification of a novel variant, biochemical findings and treatment. Journal of Pediatric Endocrinology and Metabolism [Internet]. 2016;29:15-20. Website
Nikolopoulos GK, Paraskevis D, Psichogiou M, Hatzakis A. HBV-DNA levels predict overall mortality in HIV/HBV coinfected individuals. J Med Virol. 2016;88(3):466-73.Abstract
The coinfection of Hepatitis B virus (HBV) and human immunodeficiency virus (HIV) has been associated with increased death rates. However, the relevant research has mostly relied on serologic HBV testing [HBV surface antigen (HBsAg)]. The aim of this work was to explore the relationship of HBV viraemia with overall mortality among HIV/HBV coinfected individuals. The analysis included 1,609 HIV seropositives of a previously described cohort (1984-2003) with limited exposure to tenofovir (12%) and a median follow-up of approximately 5 years. Those with persistent expression of HBsAg were further tested for HBV-DNA. The data were analyzed using Poisson regression models. Totally, 101 participants were chronic carriers of HBsAg (6.28%). Of these, 81 were tested for HBV-DNA. The median HBV-DNA levels were 3.81 log (base-10) International Units (IU)/ml. A third (31%) of those tested for HBV-DNA had received tenofovir. Before developing acquired immune deficiency syndrome (AIDS), the adjusted incidence rate ratio (IRR) for all-cause mortality of coinfected patients with HBV viraemia above the median value versus the HIV monoinfected group was 3.44 [95% confidence interval (CI): 1.05-11.27]. Multivariable regressions in the coinfected group only (n = 81) showed that one log-10 increase in HBV-DNA levels was associated with an elevated risk for death (IRR: 1.24, 95%CI: 1.03-1.49). HBV-DNA levels predict overall mortality in the setting of HIV/HBV coinfection, especially during the period before developing AIDS, and could thus help prioritize needs and determine the frequency of medical monitoring.
Papachristou E, Tsagkovits A, Zavitsanou A, Hatzakis A, Paraskevis D. HCV dispersal patterns among intravenous drug users (IDUs) in Athens metropolitan area. Infect Genet Evol. 2016;45:415-419.Abstract
BACKGROUND: Most of the HCV transmission the recent years in Greece was among IDUs. Our aim was to estimate the prevalence of HCV genotypes and to investigate the patterns of HCV dispersal among IDUs in Athens using current state of the art molecular epidemiology methods. METHODS: HCV sequences were determined from 238 HIV-negative IDUs collected on the basis of the "ARISTOTLE" prevention program carried out in Athens between 2012 and 2013. Phylogenetic trees were inferred on HCV sequences isolated from IDUs in Athens for the most prevalent HCV clades (subtypes 1a and 3a). Phylogenetic analysis was performed by Neighbor-Joining and Bayesian methods using GTR+G as nucleotide substitution model. HCV dispersal patterns were estimated using as references, all globally available HCV sequences for subtypes 1a and 3a. RESULTS: The prevalence of HCV subtypes was: 3a (59.2%), 1a (21.9%), 4 (13.0%), 1b (5.4%) and 2 (0.5%). Phylogenetic analyses revealed that most sequences (63.5%) οf subtypes 1a and 3a fell within IDU-specific monophyletic groups. The proportion of sequences in monophyletic clades was similar for subtype 3a (62.9%) and 1a (65.3%). For the latter group, monophyletic clades were smaller in size. Multivariable logistic regression analyses showed that monophyletic clustering was marginally associated recent onset of injecting ([AOR]=1.44; 95% CI (0.97-2.13), p=0.068). CONCLUSIONS: The high proportions of HCV sequences within IDU-specific monophyletic clusters suggest that transmissions occurred locally among IDUs in Greece. The numerous clusters for both 1a and 3a provide evidence that both sub-epidemics were the result of multiple introductions among the IDUs. Higher regional clustering was probably associated with a more recent onset of drug use.
Moustris KP, Proias GT, Larissi IK, Nastos PT, Koukouletsos KV, Paliatsos AG. Health impacts due to particulate air pollution in Volos City, Greece. Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering [Internet]. 2016;51:15-20. Website
Stewart AK, Dimopoulos MA, Masszi T, Špička I, Oriol A, Hájek R, Rosiñol L, Siegel DS, Niesvizky R, Jakubowiak AJ, et al. Health-related quality-of-life results from the open-label, randomized, phase III ASPIRE trial evaluating carfilzomib, lenalidomide, and dexamethasone versus lenalidomide and dexamethasone in patientswith relapsed multiple myeloma. Journal of Clinical Oncology [Internet]. 2016;34(32):3921 - 3930. WebsiteAbstract
Purpose To determine the effects of carfilzomib, lenalidomide, and dexamethasone (KRd) versus lenalidomide and dexamethasone (Rd) on health-related quality of life (HR-QoL) in the Carfilzomib, Lenalidomide, and Dexamethasone Versus Lenalidomide and Dexamethasone for the Treatment of Patients With Relapsed Multiple Myeloma (ASPIRE) trial. Methods Patients with relapsed multiple myeloma were randomly assigned to receive KRd or Rd. The European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire C30 and myeloma-specific module were administered at baseline; day 1 of cycles 3, 6, 12, and 18; and after treatment. The Global Health Status/Quality of Life (GHS/QoL) scale and seven subscales (fatigue, nausea and vomiting, pain, physical functioning, role functioning, disease symptoms, and adverse effects of treatment) were compared between groups using a mixed model for repeated measures. The percentages of responders with ≥ 5- or 15-point GHS/QoL improvement at each cycle were compared between groups. Results Baseline questionnaire compliance was excellent (94.1% of randomly assigned patients). KRd patients had higher GHS/QoL scores versus Rd patients over 18 treatment cycles (two-sided P<.001). The minimal important difference was met at cycle 12 (5.6 points) and approached at cycle 18 (4.8 points). There was no difference between groups for the other prespecified subscales from ASPIRE. A higher proportion of KRd patients met the GHS/QoL responder definition (≥ 5-point improvement) with statistical differences at cycle 12 (KRd v Rd patients, 25.5% v 17.4%, respectively) and 18 (KRd v Rd patients, 24.2% v 12.9%, respectively). Conclusion KRd improves GHS/QoL without negatively affecting patient-reported symptoms when compared with Rd. These data further support the benefit of KRd in patients with relapsed multiple myeloma. © 2016 by American Society of Clinical Oncology.
Stewart AK, Dimopoulos MA, Masszi T, Špička I, Oriol A, Hájek R, Rosiñol L, Siegel DS, Niesvizky R, Jakubowiak AJ, et al. Health-related quality-of-life results from the open-label, randomized, phase III ASPIRE trial evaluating carfilzomib, lenalidomide, and dexamethasone versus lenalidomide and dexamethasone in patientswith relapsed multiple myeloma. Journal of Clinical Oncology [Internet]. 2016;34(32):3921 - 3930. WebsiteAbstract
Purpose To determine the effects of carfilzomib, lenalidomide, and dexamethasone (KRd) versus lenalidomide and dexamethasone (Rd) on health-related quality of life (HR-QoL) in the Carfilzomib, Lenalidomide, and Dexamethasone Versus Lenalidomide and Dexamethasone for the Treatment of Pat