Publications

In Press
Chatoupis C, Vagenas G. Effectiveness of the practice style and the reciprocal style of teaching: a meta-analysis. The Physical Educator. In Press.Abstract
The purpose of this meta-analysis was to examine the effectiveness of Mosston and Ashworth’s (2008) practice and reciprocal styles of teaching on motor skill acquisition of school and university students. A systematic search in bibliographical databases led to the identification of 23 relevant studies published in peer-reviewed journals. Using certain methodological and statistical criteria, we retained six studies for further analysis. We estimated proper Effect Size (ES) statistics for each study and each teaching style. Heterogeneity of the ESs was almost negligence for the reciprocal style and moderate to large for the practice style (I2 > 50%). Both teaching styles appear to produce rather large effects, with the practice style (mean d = 1.16) having larger effects than the reciprocal style (mean d = 0.94). This meta-analysis provides an overview and synthesis of relevant studies and highlights both teaching styles for increasing K-12 and university students’ motor skill learning. The results are discussed in light of the Spectrum theory.   Keywords: meta-analysis, Spectrum, practice style, reciprocal style, motor skill
Poutzalis S, Anastasiadou A, Nasopoulou C, Megalemou K, Sioriki E, Zabetakis I. Evaluation of the in vitro anti-atherogenic activities
of goat milk and goat dairy products
. Dairy Science and Technology [Internet]. In Press. Publisher's VersionAbstract
Given that goat milk and dairy products should be consumed daily according to suggestions based on Mediterranean diet, the current study evaluates the anti-atherogenic properties of goat milk and goat dairy products (yogurt and white cheese). Total lipids (TLs) of all three samples were extracted by the method of Bligh and Dyer and further separated into total polar lipids (TPLs) and total neutral lipids (TNLs) by counter current distribution. The fatty acid profiles of TPL and TNL of all three samples were determined by gas chromatography analysis. TL and TPL were tested to determine whether they induce platelet aggregation or inhibit platelet aggregation induced by the platelet-activating factor (PAF). The most active lipids were found in goat white cheese (i.e., since they showed lower IC50 values in both TL and TPL samples than corresponding fractions of goat milk and goat yogurt), so the TPL of goat white cheese were further separated by preparative thin-layer chromatography (TLC). The obtained polar lipid fractions after TLC separation were also tested for their biological activity. All the samples’ lipids, and especially the polar ones, were found to exhibit strong anti-atherogenic activities. This fact highlights the nutritional value of goat dairy products in terms of cardioprotection, as PAF is a crucial inflammatory mediator that is implicated in the mechanism of atherogenesis.
Chatoupis C, Vagenas G. Physical education teachers' use of Moston's teaching styles: a literature review. The Physical Educator. In Press.
Vagenas G, Palaiothodorou D, Knudson D. Thirty-year trends of study design and statistics in applied sports and exercise biomechanics research. International Journal of Exercise Science [Internet]. In Press. Publisher's VersionAbstract
This study documented the change in study design and statistics employed in applied sports and exercise biomechanics research from 1985 to 2014. The sample comprised 676 data based original research reports published in the Journal of Applied Biomechanics (JAB) from 1985 to 2014. Eight design and 10 statistical criteria were extracted from each study. Descriptive statistics were calculated and change in study criteria over time were documented. Design criteria that did not change over time, remaining at relatively low levels of rigor, were widespread (71%) use of small (2-20) sample sizes and examination of numerous dependent variables (26.6% with >13). The number of experimental groups and independent variables also did not change with typically 1 to 2 reported. There was a significant 61% linear increase in randomization of participants into groups, however by 2014 still a minority (39%) of studies were not reporting randomized assignment. Types of statistical analysis showed positive changes over time with a 48% quadratic decrease in descriptive analyses, a 3% linear increase in nonparametric statistics, and a 45% linear increase in reporting parametric statistical analysis. Changes in specific statistical methods included a 9% linear decrease in bivariate correlation and a 73% linear increase in ANOVA. Reporting of assumptions had a 35% linear increase, yet in 2014 sixty-five percent still did not report on meeting statistical assumptions. Changes in test statistics included a linear 56% increase of reporting observed P values and a quadratic 29% increase in reporting effect sizes beginning in the late 1990s. It was concluded there was evidence of small improvements in research design and statistics in JAB over the last 30 years; however, there is still room for improvement to meet higher levels of research rigor and current recommendations on statistical analysis and reporting.
vagenas_palaio_knudson_2018_-_ijes.pdf
Παπαρρηγοπούλου-Πεχλιβανίδη Πατρίνα. Οι επιπτώσεις των “μνημονειακών παρεμβάσεων” στην κοινωνική ασφάλιση. ΕΔΚΑ. In Press. oi_epiptoseis_ton_mnimoneiakon_paremvaseon_stin_koinoniki_asfalisi.pdf
Forthcoming
Archaeological Research in the Kurdistan Region of Iraq and the adjacent areas. Conference Proceedings, Athens, November 1st-3rd 2013. (Kopanias K, MacGinnis J). Oxford: Archaeopress; Forthcoming. Website
Kopanias K. Das Straßennetz der Ostphokis und die Frage nach der Lokalisierung von Abai. In: Niemeier W-D Kalapodi Vorberichte. Berlin: DAI; Forthcoming. Website
Kamberidou I, Pascall N. The Digital Skills Crisis: Engendering Technology – Empowering Women in Cyberspace. In: Gender Gaps and the Social Inclusion Movement in ICT. IGI Global: International Publisher of Information Science and Technology Research (https://www.igi-global.com/ ); Forthcoming. Publisher's VersionAbstract
Invitation to publish Chapter:  ©  Kamberidou, I. & Pascall, N. (2018). The Digital skills crisis: Engendering Technology – Empowering Women in Cyberspace.  Chapter in: Gender Gaps and the Social Inclusion Movement in ICT. IGI Global: International Publisher of Information Science and Technology Research https://www.igi-global.com/    [ ...........MORE ANALYTICALLY, BOOK ENTITLED: Gender Gaps and the Social Inclusion Movement in ICT. Responsible: Idongesit Williams  Aalborg University Denmark, Olga Kretova (Ph.D fellow), , Aalborg University, Copenhagen, Denmark Roslyn Layton (Ph.D), Aalborg Unversity Denmark/ Strand Consult, Denmark Proposal Submission Deadline: December 15, 2017 ICTs have evolved from serving as a means of personal communication and organizational coordination. Today, ICTs serve as an enabler in most aspects of our daily lives. ICT adoption could help women,...  Introduction ICTs have evolved from serving as a means of personal communication and organizational coordination. Today, ICTs serve as an enabler in most aspects of our daily lives. ICT adoption could help women, and frequently their families, enjoy greater literacy, freedom, empowerment, health and so on. ICT adoption patterns in the usage of various forms of ICTS from the advent of the information age vary across gender. This has resulted in different degrees of social exclusion within different societies and different regions of the world. The degree of social exclusion also varies with respect to the adoption ICT technologies and services. Different approaches have been adopted to foster social inclusion using ICTs. In many countries, ICT policies have been proposed and adopted to enable social inclusion. But most of these policies rarely provide specific approaches towards bridging gender gaps in the adoption and usage of ICTs. In the academia, studies on gender gaps in the adoption and usage of ICTs have been ongoing through most of the digital age. There have been studies on gender patterns in the adoption and usage of different ICT and services in different contexts and global regions. Although there has been a revolution in ICT technology, services, and usage patterns, studies show that gender gaps still exist. The nature of the gender gaps differs based on what the ICT service is used for. As ICTs are now delivered via converged technologies and platforms, the divergence on gender gaps in using different services differ.   In this book, the editors will seek academic research dealing with the issues on current gender gaps and how it impacts upon social inclusion. The context of the discussion on ICT includes online and offline access to ICT. Objective This comprehensive and timely publication aims to be an essential reference source, building on the available literature in the field of Gender studies while providing for further research opportunities in this dynamic field. It is hoped that this text will provide the resources necessary for policymakers, academics, researchers, International Governmental organizations, etc, identify current challenges and solutions towards social inclusion with respect to gender. Target Audience Policy makers, academicians, researchers, advanced-level students, technology developers, and government officials will find this text useful in furthering their research exposure to current gender-related issues hampering social inclusion enabled by ICT.
Karavanta M. William V. Spanos’s Onto-Political Criticism: Risky A-filiations and the Call of the Korē’s Meidiama.”. boundary 2. Forthcoming.Abstract
This essay discusses William V. Spanos’s work as the legacy of what can be called “onto-political criticism.” Spanos’s affiliation between texts and the world discloses the overlapping of the history of imperialistic and colonial violence with the politics of ontology, what constitutes the discourses, ideologies and institutions that produce and consolidate the metaphysics of imperialism. Drawing on Martin Heidegger and the poststructuralists, Spanos’s work demonstrates how metaphysics is not inconsequential; it is the discursive and political reproduction of a certain concept of being as a measure for other humans and as a philosophical and political justification for their dispossession, enslavement and extermination that is the very fist act of colonization. His insistence on the poststructuralists’ legacy of an antihumanist practice that desires to articulate the poetics and politics of the ontologies of alterity is not indifferent to politics. Spanos thus unearths the “overlapping territories and intertwined histories” (Said) constitutive of the polis within the histories of colonialism, imperialism and neo-imperialism, the latter being his key focus in his analyses of American exceptionalism in the age of globalization. His onto-political a-filiation establishes the possibility of articulating a kind of criticism that, while recognizing the history of this axiomatics of ontopology, also imagines and articulates the potentiality that is ex-centric (the derivative and negative prefix “a-” signifies this) to its narratives, discourses and politics. Spanos’s legacy opens the possibility for a community of method driven by “the thought of a differential polity,” a constitutive element of a truly democratic politeia.  
Vassiloyannis P. Person's Dominion: Inviolability, Method, and Value.; Forthcoming.
Kopanias K. From the Mythical Atreus to the Ruler Attarissiya. Aegean Kingship in the Late Bronze Age through the Prism of Near Eastern Texts. In: Kaiser I, Kouka O, Panagiotopoulos D Ein Minoer im Exil. Festschrift zum 65. Geburtstag von Wolf-Dietrich Niemeier. Bonn: Habelt; Forthcoming. Website
Kopanias K, Fox S. Headshaping at Tell Nader. In: Mina M, Papadatos Y, Triantaphyllou S Embodied Identities In The Prehistoric Eastern Mediterranean: Convergence Of Theory And Practices. Conference hosted by the University of Cyprus, 10-12 April 2012, Nicosia, Cyprus. Oxford: Oxbow Books; Forthcoming. Website
Coakley J, Dotsis G, Liu H, Zhai J. Investor Sentiment and Value and Growth Stock Index Options. European Journal of Finance. Forthcoming.
Kopanias K. Mycenaean Mercenaries in the Service of Suppiluliuma II?. In: Polychronakou-Sgouritsa P, Palaggia O Proceedings of a Symposion in Memory of Professor Spyridon Iakovides. Athens; Forthcoming.
Karavanta M.

"The Illegal Human: Democracy In-Surgent"

. Journal of Contemporary Thought. Special Issue Speaking Truth to Power, Ed. R.Radhakrishnan. Forthcoming.Abstract
The history of the human as excess that cannot be eliminated and is the body of exappropriation, the body of a différance is repeated in the present. It is the history of the illegal human being written by the multiple crossings of borders by a growing number of peoples who are refugees, exiles, and economic immigrants without documents. This is an old history--as Achille Mbembe reminds us in his analysis of le nègre in Critique de la Raison Négre--but also a new one. The substantive of the nègre is now being replaced by the substantive of the illegal as the people without documents or the boat people are often called. The illegal is a substantive whose repetition registers the stark denotations of danger and threat and is used by the state authorities and the media to vindicate the European policies and practices that separate the immigrant from the human, once again repeating the fate of the stateless human without rights. By drawing on Mbembe’s analysis of   le nègre and the promise of a humanity in-surgent and Jacques Derrida’s “strange syntagma” of a democracy-to-come, this essay demonstrates how this particular story of the illegal human is another twist in the long history of the human as a subject of exappropriation who speaks truth to power while bearing the promise of a humanity that is in-surgent, which is the promise for a democracy radically different from the neoliberal model available in the present. The essay discusses how this “to come” of democracy invokes the discomfort zone of becoming human in the company of those humans whose lives are precarious and are exempted from the present democratic imaginaries as examples of bare life or, even more poignantly called, beastly life.  
Popular religion and ritual in the east Mediterranean from the 3rd millennium BC to the 5th century AD. Proceedings of the International Conference by the Department of History and Archaeology of the University of Athens, December 2013. (Vavouranakis G, Papadatos Y, Kopanias K, Kanellopoulos C). Oxford: Oxbow Books; Forthcoming. Website
sfdsf sdfdf. sfdsfdf. Forthcoming.Abstract
sdfsdf
Blondel J, Aronson J, Bodiou J-Y, Boeuf G. Η Μεσογειακή περιοχή: Βιοποικιλότητα στο χώρο και το χρόνο
. Αθήνα: Παρισιάνου; Forthcoming.
Kopanias K, Beuger C, MacGinnis J, Ur J. The Tell Baqrta Project in the Kurdistan Region of Iraq. In: MacGinnis J Proceedings of the Conference Provincial Archaeology of the Assyrian Empire, December 13-Saturday December 15 2012, organized by the MacDonald Institute for Archaeological Research of the University of Cambridge. Cambridge: McDonald Institute Monographs Series; Forthcoming. Publisher's Version
Kopanias K, MacGinnis J. The Tell Nader Project in the Erbil Province: the Stratigraphy. In: Kopanias K Archaeological Research in the Kurdistan Region of Iraq and the adjacent areas. Conference Proceedings, Athens, November 1st-3rd 2013. Oxford: Archaeopress; Forthcoming.
Kopanias K. Ubaid ‘islands’ in a non-Ubaid ‘sea’: An Attempt to Define the Ubaid and its Cultural Boundaries in Northeastern Mesopotamia. In: Baysal E, Karakatsanis L Bordered Places. Bounded Times. Cross-disciplinary perspectives on Turkey. London: The British Institute at Ankara; Forthcoming. Publisher's Version kopanias_ubaid.pdf
Kopanias K. An Ubaid Kiln at Tell Nader (Kurdistan Region in Iraq). In: Masetti-Rouault MG, Rouault O Proceedings of the International Congress “Archaeology and History of the Empires: Models, projects and work in progress in Northern Mesopotamia. New programs in Iraqi Kurdistan”, Paris, Ecole Pratique des Hautes Etudes, Sorbonne, 14-15 juin 2013. EMMS I. Paris; Forthcoming.
Triantafyllou A, Dotsis G, Sarris AH. Volatility Forecasting and Time-Varying Variance Risk Premiums in Grain Commodity Markets. Journal of Agricultural Economics. Forthcoming.
Kopanias K. Αρχαιολογική έρευνα στις θέσεις Tell Nader και Tell Baqrta στην Κουρδική περιφέρεια του βορείου Ιράκ [=Archaeological Research in Tell Nader and in Tell Baqrta in the Kurdistan Region of I. In: Kousoulis P Πρακτικά Συνεδρίου «{EX} {ORIENTE} {LUX}. 1ο Πανελλήνιο Συμπόσιο για την Ερευνα και Διδασκαλία των Πολιτισμών της Αιγύπτου, Εγγύς Ανατολής και Κύπρο. Athens: Papazisis; Forthcoming. Publisher's Version
Antonio G. Δοκιμή. Forthcoming.
Φωτεινός Δημήτρης, Μπουζάκης Σήφης. Η εκπαιδευτική μεταρρύθμιση του 1964: ο διάλογος μέσα από τον Τύπο.; Forthcoming.
Kopanias K. Συστήματα οικονομικής διαχείρισης στη Μεσοποταμία (4η-2η χιλιετία π.Χ.) [=Systems of economic administration in Mesopotamia (4th – 2nd mill. B.C.]. In: Kalogerakou P, Sgouritsa N Τιμητικός τόμος για τον καθηγητή Γεώργιο Στυλ. Κορρέ. Athens; Forthcoming. Publisher's Version
Submitted
Submitted.
Miletic V, Maniadakis D, Mikac B, Varoutas D. 2014 10th International Conference on the Design of Reliable Communication Networks (DRCN). Submitted.
Tselekounis M, Varoutas D, Martakos D. Access Pricing Under Stackelberg Competition: Results Interpretation and Regulatory Implications. Submitted.
Dracopoulos MC, Vlahos N. Approximate Inverse Preconditioning for Multilevel Finite Element Matrices. Submitted.
Dracopoulos MC. Assigning Coordinates to Graphs for Partitioning. Submitted.
Kakaletris G, Varoutas D, Katsianis D, Sphicopoulos T. Biometric Authentication in Broadband Networks for Location-Based Services. Submitted.
Dracopoulos MC. Damping the Effects of Ill-Conditioning in CG Iterations. Submitted.
Kamalakis T, Varoutas D, Sphicopoulos T, Lancis J, Climent V, Caraquitena J, Saavedra G, Mart{\'ınez-Corral M, Andrés P, Wang C, et al. DC Drift of X-Cut LiNbO3 Modulators............... H. Nagata, Y. Li, WR Bosenberg, and GL Reiff 2233 Transverse Bragg-Resonant Enhancement of Modulation and Switching..... W. Liang, Y. Xu, JM Choi, A. Yariv, and W. Ng 2236 Propagation a. Submitted.
Varoutas D, Michalakelis C, Vavoulas A, Deligiorgi K. Diffusion Forecasting and Price Evolution of Broadband Services in Europe. Submitted.
Deligiorgi C, Vavoulas A, Michalakelis C, Varoutas D, Sphicopoulos T. Factors and characteristics affecting ADSL tariffs in Europe. Submitted.
Katsianis D, Varoutas D, Sphicopoulos T, Loizillon F, Harno J, Kalhagen K-O, Stordahl K, Olsen BT, Welling I. Final results on the economic viability of 3G MVNOs. Submitted.
Vlachogiannis E, Viorres N, Bolis S, Neofytou O. THE GREEK UNIVERSITIES INTO THE DIGITAL WORLD—THE U-PORTAL CASE STUDY. Submitted.
Varoutas D, Kamalakis T, Katsianis D, Sphicopoulos T, Monath T, Athens Greece GR15784. Importance of the Maturity of Photonic Component Industry on the Business Prospects of Optical Access Networks: A Techno-economic Analysis. Submitted.
Konstantinidou AE, Patsouris E, NICOLOPOULOU-STAMATI P. INTRA UTERUS IMPACT OF ENDOCRINE DISRUPTERS. special issue special issue. Submitted:79.
Loizillon F, Harno J, Stordahl K, Welling I, Kalhagen BO, Varoutas D, Katsianis D, Roy J, Borrego DM, de Sousa A. IST-2000-25172 TONIC Deliverable number 11 Final results on seamless mobile IP service provision economics. Submitted.
de Oliveira Duarte M, Stordahl K, Kalhagen KO, Harno J, Elnegaard NK, Olsen BT, Monath T, Ferreira N, Castro E, Pego P, et al. IST-2000-25172 TONIC Deliverable number 8. Submitted.
Chipouras A, CRAIGNOU B, Telecom F, Gavish B, UniZH BS, Zurich ETH, TUM SCMM, Karamti C, Paris ENST, Michalakelis C, et al. Jan Derkacz AGHUniversity of Science and Technology. Submitted.
Michalakelis C, Dede G, Zerva A, Varoutas D, Sphicopoulos T. A methodology for estimating price and diffusion elasticity: an application to telecommunications. Submitted.
Dracopoulos MC. A Multithreaded Finite Element Algorithm with Element-by-Element Preconditioning. Submitted.
Konstantinidou AE. OA CASE REPORTS. Submitted.
Solano F, Pióro M, Pei Y, Zhang X, Xu K, Sun X, Hraimel B, Wu J, Lin J, Marchetto G, et al. Optical Communications and Networking. Submitted.
Coiro A, Listanti M, Valenti A, Matera F, Belmonte A, Kahn JM, Tsubokawa M, Honda N, Azuma Y, Dede G, et al. Optical Communications and Networking. Submitted.
Dracopoulos MC, Glasgow C, Parrott AK, Simkin J. Parallel Performance Prediction for Finite Element Computations. Submitted.
Kouloumentas C, Avramopoulos H, Couris S, Rokkas T, Varoutas D, Vasilopoulou M, Davazoglou D, Pistolis G, Argitis P. Polymer Photonic Technologies for Optical Communications. Submitted.
Varoutas D, Deligiorgi K, Michalakelis C, Sphicopoulos T. Price indexes for telecom market: An application to European market of leased lines. Submitted.
Dracopoulos MC. A Quasi-{N}ewton Approximate Inverse Preconditioner. Submitted.
Patsantaras N, KAMPERIDOU IRENE, PANAGIOTOPOULOS PANAGIOTIS. SOCIAL INCLUSION OR RACISM AND XENOPHOBIA?. Submitted.
Maniadakis D, Varoutas D. Structural properties of urban street networks of varying population density. Proceedings of the 10th European Conference on Complex Systems (ECCS’13) Barcelona. Submitted:1–6.
A System of Systems Framework for the Reliability Assessment of Telecommunications Networks. Submitted.
A System of Systems Framework for the Reliability Assessment of Telecommunications Networks. Submitted.
Stordahl K, Varoutas D. Techno-Economic Evaluation of 3G & WLAN Business Case Feasibility Under Varying Conditions. Submitted.
Katsianis D, Varoutas D, Orfanos I, Sphicopoulos T, Pantelis S. A techno-economic evolutionary path for access technologies. Submitted.
Dede G, Varoutas D, Kamalakis T, Goni G, Javaudin JP. Technological and Socio-Economic Issues Affecting the Deployment of Home Networks: Evidence from the ICT-OMEGA project. Submitted.
Kakaletris G, Varoutas D, Katsianis D, Kouvas G, Zacharopoulos I, Naumanen V, Sarvela H, Zoumpadelis F, Garbi A, Silvennoinen M, et al. User Needs & Market Analysis. M-Guide Deliverable D. Submitted;2.
2917
From a "Garden of Disorder to a "Nest of Flames": Charles Henri Ford's Surrealist Inflections. Miranda: Revue pluridisciplinaire du monde anglophone [Internet]. 2917;14. Publisher's VersionAbstract
Virtually omitted from established narratives of American modernism, yet central in the histories of the reception of European Surrealism in the US, Charles Henri Ford’s life and work have been recovered in important queer genealogies within Anglo-American modernism. Yet within this process or recovery, Ford’s poetic work is still largely overlooked, and this may have to do less with its marked Surrealist influences and/or derivative aspects than with the somewhat unclassifiable and composite texture of Ford’s poems. This article revisits Ford’s early poetry as a space of convergence and dialogue between distinct yet interrelated poetics: from the 1938 A Garden of Disorder to the 1949, Sleep in a Nest of Flames, a queer subjectivity assimilates concurrently Surrealist poetics and Djuna Barnes’s equally unclassifiable queer modernism with and against American poetic modernisms.
2018
Kamberidou I. 365 DIRECT CITATIONS – 365 ΑΝΑΦΟΡΕΣ ΑΠΕΥΘΕΙΑΣ ΣΤΟ ΕΡΓΟ. UoA Scholar: http://scholar.uoa.gr/ikamper/publications, National and Kapodistrian University of Athens]. 2018;(Updated Jan. 10, 2017):1-47.Abstract
  • 365 direct citations since 2003 (updated Jan. 21,  2018): 365 ετεροναφορές/παραπομπές/αναφορές—απευθείας στο έργο— σε επιστημονικά περιοδικά, βιβλία, πρακτικά συνεδρίων, διδακτορικές διατριβές, κ.ά., από το 2003 έως σήμερα 21/1/2018.
365_direct_citations_updated_jan._21_2018.pdf
Iliou K, Malenović A, Loukas YL, Dotsikas Y. Analysis of potential genotoxic impurities in rabeprazole active pharmaceutical ingredient via Liquid Chromatography-tandem Mass Spectrometry, following quality-by-design principles for method development. Journal of Pharmaceutical and Biomedical Analysis [Internet]. 2018;149:410-418. Website
Mirza SB, Lee RCH, Chu JJH, Salmas RE, Mavromoustakos T, Durdagi S. Discovery of selective dengue virus inhibitors using combination of molecular fingerprint-based virtual screening protocols, structure-based pharmacophore model development, molecular dynamics simulations and in vitro studies. Journal of Molecular Graphics and Modelling [Internet]. 2018;79:88 - 102. Website
Kamberidou I. Frédéric Barbier, The Greek Dream by Monsieur de Choiseul: The Travels of a European of the Enlightenment. [Review of the Book: Le rêve grec de Monsieur de Choiseul Les voyages d'un européen des Lumières by Frédéric Barbier]. Journal of Modern Greek Studies (Print ISSN: 0738-1727, Online ISSN: 1086-3265) [Internet]. 2018;35:564–612. Publisher's VersionAbstract
John Hopkins University Press:  (PROJECT MUSE: https://muse.jhu.edu/article/671081) Irene Kamberidou (2017). Journal of Modern Greek StudiesVolume 35, Number 2, October 2017, pp. 564-570 | 10.1353/mgs.2017.0031       [[Praised as "a magnificent scholarly journal" by Choice magazine, Journal of Modern Greek Studies is the only scholarly periodical to focus exclusively on modern Greece. The Journal publishes critical analyses of Greek social, cultural, and political affairs, covering the period from the late Byzantine Empire to the present. Contributors include internationally recognized scholars in the fields of history, literature, anthropology, political science, Byzantine studies, and modern Greece. Journal of Modern Greek Studies is the official publication of the Modern Greek Studies Association (MGSA).]]..............ARTICLE CITATION:  Kamberidou, Irene (2017). Frédéric Barbier, The Greek Dream by Monsieur de Choiseul: The Travels of a European of the Enlightenment. [Review of the Book:  Le rêve grec de Monsieur de Choiseul Les voyages d'un européen des Lumières by Frédéric Barbier] Journal of Modern Greek Studies 35 (2017) 564–612 © 2017 by The Modern Greek Studies Association. Print ISSN: 0738-1727,  Online ISSN:  1086-3265. John Hopkins University Press: https://www.p     ***** The Greek Dream by Monsieur de Choiseul: The Travels of a European of the Enlightenment by Frédéric Barbier Journal Article published 2017 in Journal of Modern Greek Studies volume 35 issue 2 on pages 564 to 570 Author: Irene Kamberidou  https://doi.org/10.1353/mgs.2017.0031  , John Hopkins University Press
the_greek_dream.pdf
Tsokos Α, Kotsi Ε, Petrakis S, Vassilakis E.

Combining series of multi-source high spatial resolution remote sensing datasets for the detection of shoreline displacement rates and the effectiveness of coastal zone protection measures

. Journal of Coastal Conservation [Internet]. 2018. Publisher's VersionAbstract
The long-term change of the shoreline location is a phenomenon, which is highly factored in the design of construction projects along the coastal zone. Especially, beach erosion is characterized as one of the major problems at coastal areas and it is of high importance as a quite significant percentage of social development is concentrated in a relatively narrow zone not far from the waterfront. This study presents a methodology that aims to quantify the shoreline displacement rate by involving the processing of different types of remote sensing datasets such as aerial photographs, satellite images and unmanned aerial system data coupled with in-situ observations and measurements. Several photogrammetric techniques were used in order to orthorectify and homogenize a time series of remotely sensed data acquired from 1945 to 2017, representing a rapidly relocating coastal zone at the southern part of Corinth Gulf (Greece), as a case study. All images were digitally processed and optically optimized in order to produce a highly accurate representation of the shoreline at the time period of each acquisition. The data were imported in a Geographic Information System platform, where they were subjected to comparison and geostatistical analysis. High erosion rates were calculated, reaching the order of 0.18 m/year on average whilst extreme rates of 0.70 m/year were also observed in specific locations leading to the segmentation of the coastal zone according to its vulnerability and consequently the risk for further development as well as the effectiveness of measures already taken by the authorities. 
2017
Kokotou MG, Galiatsatou G, Magrioti V, Koutoulogenis G, Barbayianni E, Limnios D, Mouchlis VD, Satpathy B, Navratil A, Dennis EA, et al. 2-Oxoesters: A Novel Class of Potent and Selective Inhibitors of Cytosolic Group IVA Phospholipase A2. Scientific Reports. 2017;7:7025.Abstract
Cytosolic phospholipase A2 (GIVA cPLA2) is the only PLA2 that exhibits a marked preference for hydrolysis of arachidonic acid containing phospholipid substrates releasing free arachidonic acid and lysophospholipids and giving rise to the generation of diverse lipid mediators involved in inflammatory conditions. Thus, the development of potent and selective GIVA cPLA2 inhibitors is of great importance. We have developed a novel class of such inhibitors based on the 2-oxoester functionality. This functionality in combination with a long aliphatic chain or a chain carrying an appropriate aromatic system, such as the biphenyl system, and a free carboxyl group leads to highly potent and selective GIVA cPLA2 inhibitors (XI(50) values 0.00007–0.00008) and docking studies aid in understanding this selectivity. A methyl 2-oxoester, with a short chain carrying a naphthalene ring, was found to preferentially inhibit the other major intracellular PLA2, the calcium-independent PLA2. In RAW264.7 macrophages, treatment with the most potent 2-oxoester GIVA cPLA2 inhibitor resulted in over 50% decrease in KLA-elicited prostaglandin D2 production. The novel, highly potent and selective GIVA cPLA2 inhibitors provide excellent tools for the study of the role of the enzyme and could contribute to the development of novel therapeutic agents for the treatment of inflammatory diseases.
Alevizaki A, Sainidou R, Rembert P, Morvan B, Stefanou N. Acoustic properties of double-porosity granular polymers. Physical Review B. 2017;95(21):214306 (10 pages).Abstract
Using an extension of the full elastodynamic layer-multiple-scattering method to structures of fluid-saturated poroelastic spherical bodies, a comprehensive theoretical study of the acoustic response of double-porosity submerged liquid-saturated granular polymeric materials of specific morphology consisting of touching porous polymer spheres arranged in a fcc lattice, beyond the long-wavelength effective-medium description, is presented. Calculated transmission and absorption spectra of finite slabs of these materials are analyzed by reference to the acoustic modes of the constituent porous spherical grains as well as to relevant dispersion diagrams of corresponding infinite crystals, and a consistent interpretation of the results is provided. In particular, it is shown that resonant modes with very long lifetime, localized in the spheres in the form of slow longitudinal waves, which are peculiar to poroelastic materials, are formed when the viscous length is much shorter than the radius of the inner pores of the spheres. These modes, which can be easily tuned in frequency by adjusting the intrinsic porosity of the spheres, induce some remarkable features in the acoustic behavior of these double-porosity materials, such as narrow dispersionless absorption bands and directional transmission gaps.
Aktionsart, aspect and category change in the history of Greek
Moser A. Aktionsart, aspect and category change in the history of Greek. In: K. Bentein, M. Janse & J. Soltic (eds.) Variation and Change in Ancient Greek Tense, Aspect and Modality. Leiden/Boston: Brill; 2017. pp. 131-157. Publisher's VersionAbstract
Aspect is more or less universally recognized as the defining TMA category of the Greek verbal system. There is a consensus on this in both the philological tradition and the linguistic literature on aspect. It is moreover almost universally accepted that diachronically the Greek verbal system has been extremely conservative, remaining practically unchanged down to the present day.This paper largely accepts the former assumption, but not the latter, which has been increasingly challenged in the last few years. It is argued here that, while there has been little change morphologically, the system has been altered in a fundamental way. More specifically, it takes up the analysis proposed in Moser (2008 and 2009), according to which the history of the Greek verb indicates that the system of three (and later two) stems shifts from the expression of Aktionsart (actionality/lexical aspect) to the expression of (grammatical) aspect, and develops it further, taking a fresh look at the data from a different point of view and in the light of recent studies.
Amphipolitics: archaeological performance and governmentality in Greece under the crisis. In: Greece in Crisis. The Cultural Politics of Austerity. London: I.B. Tauris; 2017. pp. 65-84.
Martzoukou O, Amillis S, Zervakou A, Christoforidis S, Diallinas G. The AP-2 complex has a specialized clathrin-independent role in apical endocytosis and polar growth in fungi. Elife. 2017;6.Abstract
Filamentous fungi provide excellent systems for investigating the role of the AP-2 complex in polar growth. Using Aspergillus nidulans, we show that AP-2 has a clathrin-independent essential role in polarity maintenance and growth. This is in line with a sequence analysis showing that the AP-2 β subunit (β2) of higher fungi lacks a clathrin-binding domain, and experiments showing that AP-2 does not co-localize with clathrin. We provide genetic and cellular evidence that AP-2 interacts with endocytic markers SlaB(End4) and SagA(End3) and the lipid flippases DnfA and DnfB in the sub-apical collar region of hyphae. The role of AP-2 in the maintenance of proper apical membrane lipid and cell wall composition is further supported by its functional interaction with BasA (sphingolipid biosynthesis) and StoA (apical sterol-rich membrane domains), and its essentiality in polar deposition of chitin. Our findings support that the AP-2 complex of dikarya has acquired, in the course of evolution, a specialized clathrin-independent function necessary for fungal polar growth.
Dahl V, Amnå E, Banaji S, Landberg M, Šerek J, Ribeiro N, Beilmann M, Pavlopoulos V, Zani B. Apathy or alienation? Political passivity among youths across eight European Union countries. European Journal of Developmental Psychology [Internet]. 2017:1-18. doi
Kouroutzoglou J, Avgoustoglou E, Flocas HA, Hatzaki M, Skrimizeas P, Lalos A, Keay K, Simmonds I. Assessing the Sensitivity of COSMO/GR Atmospheric Model to Effectively Simulate the Influence of Diabatic Heating on Eastern Mediterranean Explosive Cyclogenesis Under Different Parameterizations of the Model Physics. In: Karacostas T, Bais A, Nastos PT Perspectives on Atmospheric Sciences. 1st ed. Springer International Publishing; 2017. pp. 9–15.
Nastos PT, Vassilakis E, Nastos M-PP, Charalampopoulos I, Matzarakis A. Assessment of continuous sky view factor based on ultra-high resolution natural colour images acquired by remotely piloted airborne systems for applications in an urban area of Athens. International Journal of Remote Sensing [Internet]. 2017;38:5814-5829. pdfAbstract
The thermal comfort conditions in a complex urban area is influenced by the surrounding structures and obstacles which modify the incoming radiation fluxes. A measure of this modification is the sky view factor (SVF), which could be estimated in each point of a selected area if a high resolution digital elevation model (DEM), or other urban morphological data including the manmade infrastructure, are available. The goal of this study is to model the continuous SVF for a complex building environment in the campus of National and Kapodistrian University of Athens, based on a high resolution DEM (0.09 m). For this purpose, we applied the structure-from-motion (SfM) technique, which takes advantage of the interpretation of ultra-high resolution colour images acquired by remotely piloted airborne systems, also known as drones or unmanned aerial vehicles. A quantitative analysis, by applying statistical metrics, yields perfect agreement between modelled and observed SVF values, over the examined area. The proposed methodology could be applied for human-biometeorology research in micro scale complex urban environments.
Caprara GV, Vecchione M, Schwartz SH, Schoen H, Bain PG, Silvester J, Cieciuch J, Pavlopoulos V, Bianchi G, Kirmanoglu H. Basic values, ideological self-placement, and voting: A cross-cultural study. Cross-Cultural Research [Internet]. 2017;51(4):388-411. Publisher's Version
Almpanis E, Pantazopoulos PA, Papanikolaou N, Yannopapas V, Stefanou N. A birefringent etalon enhances the Faraday rotation of thin magneto-optical films. Journal of Optics. 2017;19(7):075102 (8 pages).Abstract
The magneto-optical response of a Faraday-active Fabry–Pérot etalon with birefringent mirrors is studied by means of electrodynamic simulations using the finite-element and the scattering-matrix methods. The specific structure under consideration consists of a magnetic garnet film sandwiched between two metallic layers, patterned with periodically spaced parallel grooves on their outer sides. Our results are analyzed by reference to the properties of the individual structural components and a consistent interpretation of the different spectral features observed is provided. It is shown that, by properly adjusting the geometrical parameters involved, strong Faraday rotation enhancement can be obtained through constructive synergy between the Fabry–Pérot resonant mode of the magneto-optical nanocavity and the slot plasmon mode localized in the grooves.
Bakalis E, Mertzimekis TJ, Nomikou P, Zerbetto F. Breathing Modes of Kolumbo underwater volcano (Greece). Nature Sci. Rep. 2017.
Mazis I, Sgouros G. Cable and pipeline corridors under the legal framework of UNCLOS and the Energy Treaty. Geopolitical considerations at the Eastern Mediterranean Sea. Regional Science Inquiry. 2017;IX(1).Abstract
This article is divided in three sections; the first is presenting the plethora of fiber optic and power cable geographical distribution, providing to the reader an insight to underwater infrastructure. Readers can bind together the importance of survey, lay, repair and maintenance of underwater cables and pipelines, based on the legal framework provided by the Energy Treaty and UNCLOS. The second section provides a brief report on notions mentioned in the International Energy Treaty. We also mention the Energy Treaty and the Energy Treaty Charter as a case study for pipeline and power cable installations; At the third section, we focus especially at the genesis of UNCLOS with regards to the EEZ maritime zone regime; At this section, we will present the difference between the terms marine research and cable route study, based on the applicable UNCLOS conventional terminology. The last section of this article will be an effort to carefully examine whether these two Treaties are sufficient to regulate transnational cable surveying and laying operations under the current geopolitical frame in the Eastern Mediterranean Sea; as new oil and gas fields are being developed in the region two factors affect the geopolitical equilibrium: 1) The disputed EEZ's in the Eastern Mediterranean, 2) The role of Turkey based on its destabilizing and revisionist stand as this is highlighted by extreme geopolitical behaviors causing the present instability in the geopolitical environment of the Eastern Mediterranean, mainly with regards to the supply of energy from discovered gas reservoirs in the Eastern Mediterranean.
rsi_june_2017_ix_1.pdf
Papaioannou TG, Vavuranakis M, Tousoulis D. Calibration of noninvasive central blood pressure devices and negative aortic-to-brachial systolic pressure amplification. Kidney International [Internet]. 2017;91(1):253 - 254. Website
Chng W-J, Goldschmidt H, Dimopoulos MA, Moreau P, Joshua D, Palumbo A, Facon T, Ludwig H, Pour L, Niesvizky R, et al. Carfilzomib–dexamethasone vs bortezomib–dexamethasone in relapsed or refractory multiple myeloma by cytogenetic risk in the phase 3 study ENDEAVOR. Leukemia [Internet]. 2017. WebsiteAbstract
The randomized phase 3 study ENDEAVOR demonstrated a statistically significant and clinically meaningful improvement in progression-free survival (PFS) for carfilzomib and dexamethasone (Kd) vs bortezomib and dexamethasone (Vd) in relapsed or refractory multiple myeloma (MM). We conducted a preplanned subgroup analysis of ENDEAVOR to evaluate Kd vs Vd by cytogenetic risk. Of 785 patients with known cytogenetics, 210 (27%) had high-risk cytogenetics (Kd, n=97 (25%); Vd, n=113 (28%)) and 575 (73%) had standard-risk cytogenetics (Kd, n=284 (75%); Vd, n=291 (72%)). Median PFS in the high-risk group was 8.8 months for Kd vs 6.0 months for Vd (hazard ratio (HR), 0.65; 95% confidence interval (CI), 0.45–0.92; P=0.0075). Median PFS in the standard-risk group was not estimable for Kd vs 10.2 months for Vd (HR, 0.44; 95% CI, 0.33–0.58; P<0.0001). Overall response rates were 72.2% (Kd) vs 58.4% (Vd) in the high-risk group and 79.2% (Kd) vs 66.0% (Vd) in the standard-risk group. In the high-risk group, 15.5% (Kd) vs 4.4% (Vd) achieved a complete response (CR) or better. In the standard-risk group, 13.0% (Kd) vs 7.9% (Vd) achieved ⩾CR. This preplanned subgroup analysis found that Kd was superior to Vd in relapsed or refractory MM, regardless of cytogenetic risk.Leukemia advance online publication, 3 February 2017; doi:10.1038/leu.2016.390. © 2017 The Author(s)
Chng W-J, Goldschmidt H, Dimopoulos MA, Moreau P, Joshua D, Palumbo A, Facon T, Ludwig H, Pour L, Niesvizky R, et al. Carfilzomib–dexamethasone vs bortezomib–dexamethasone in relapsed or refractory multiple myeloma by cytogenetic risk in the phase 3 study ENDEAVOR. Leukemia [Internet]. 2017. WebsiteAbstract
The randomized phase 3 study ENDEAVOR demonstrated a statistically significant and clinically meaningful improvement in progression-free survival (PFS) for carfilzomib and dexamethasone (Kd) vs bortezomib and dexamethasone (Vd) in relapsed or refractory multiple myeloma (MM). We conducted a preplanned subgroup analysis of ENDEAVOR to evaluate Kd vs Vd by cytogenetic risk. Of 785 patients with known cytogenetics, 210 (27%) had high-risk cytogenetics (Kd, n=97 (25%); Vd, n=113 (28%)) and 575 (73%) had standard-risk cytogenetics (Kd, n=284 (75%); Vd, n=291 (72%)). Median PFS in the high-risk group was 8.8 months for Kd vs 6.0 months for Vd (hazard ratio (HR), 0.65; 95% confidence interval (CI), 0.45–0.92; P=0.0075). Median PFS in the standard-risk group was not estimable for Kd vs 10.2 months for Vd (HR, 0.44; 95% CI, 0.33–0.58; P<0.0001). Overall response rates were 72.2% (Kd) vs 58.4% (Vd) in the high-risk group and 79.2% (Kd) vs 66.0% (Vd) in the standard-risk group. In the high-risk group, 15.5% (Kd) vs 4.4% (Vd) achieved a complete response (CR) or better. In the standard-risk group, 13.0% (Kd) vs 7.9% (Vd) achieved ⩾CR. This preplanned subgroup analysis found that Kd was superior to Vd in relapsed or refractory MM, regardless of cytogenetic risk.Leukemia advance online publication, 3 February 2017; doi:10.1038/leu.2016.390. © 2017 The Author(s)
Mitsi E. "The Caryatid and the Collector: British Travel Writing and the Material Past in Early Nineteenth-Century Athens". Travelling around Cultures: Collected Essays on Literature and Art. 2017:228-44.
Caryatids lost and regained: rebranding the classical body in contemporary Greece. Journal of Greek Media & Culture [Internet]. 2017;3(1):3-29. Publisher's VersionAbstract
This article examines patterns of reception through which a particular type of classical sculpture – the Caryatid – has been accepted into the cultural life of contemporary Greece. Loved by neoclassical architecture, though also prominent in Modern Greek design, as well as contemporary poetry and drama, the Caryatid serves as a logo for the country and the Greeks at large, especially when referring to their relations with their fellow-Europeans. In contemporary Greek culture, Caryatids are deployed as symbols of Greekness as well as a means to achieve the nation’s cultural emancipation against the supremacy of western, globalised modernity. Often derided as mere symptoms of colonial mimicry, through their inherent qualities of parody and subversiveness, such uses may sometimes prove unexpectedly successful in undermining modernity and its templates.
Krys K, Capaldi CA, Tilburg W, Lipp OV, Bond MH, Vauclair C, Manickam SLS, Domínguez‐Espinosa A, Torres C, Lun VM‐C. Catching up with wonderful women: The women‐are‐wonderful effect is smaller in more gender egalitarian societies. International Journal of Psychology [Internet]. 2017. doi
Melagraki G, Ntougkos E, Rinotas V, Papaneophytou C, Leonis G, Mavromoustakos T, Kontopidis G, Douni E, Afantitis A, Kollias G. Cheminformatics-aided discovery of small-molecule Protein-Protein Interaction (PPI) dual inhibitors of Tumor Necrosis Factor (TNF) and Receptor Activator of NF-κB Ligand (RANKL). PLoS Computational Biology [Internet]. 2017;13(4). Website
Grigori K, Loukas YL, Malenović A, Samara V, Kalaskani A, Dimovasili E, Kalovidouri M, Dotsikas Y. Chemometrically assisted development and validation of LC–MS/MS method for the analysis of potential genotoxic impurities in meropenem active pharmaceutical ingredient. Journal of Pharmaceutical and Biomedical Analysis [Internet]. 2017;145:307-314. Website
Banaji S, Mejias S, Kouts R, Piedade F, Pavlopoulos V, Tzankova I, Mackova A, Amnå E. Citizenship’s tangled web: Associations, gaps and tensions in formulations of European youth active citizenship across disciplines. European Journal of Developmental Psychology [Internet]. 2017:1-20. doi
Schulpis KH, Thodi G, Iakovou K, Chatzidaki M, Dotsikas Y, Molou E, Triantafylli O, Loukas YL. Clinical evaluation and mutational analysis of GALK and GALE genes in patients with galactosemia in Greece: One novel mutation and two rare cases. Journal of Pediatric Endocrinology and Metabolism [Internet]. 2017;30:775-779. Website
Ntountaniotis D, Vanioti Μ, Kordopati GG, Kellici TF, Marousis KD, Mavromoustakos T, Spyroulias GA, Golic Grdadolnik S, Tselios TV. A combined NMR and molecular dynamics simulation study to determine the conformational properties of rat/mouse 35-55 myelin oligodendrocyte glycoprotein epitope implicated in the induction of experimental autoimmune encephalomyelitis. Journal of Biomolecular Structure and Dynamics [Internet]. 2017;35(7):1559 - 1567. Website
de Vries RP, Riley R, Wiebenga A, Aguilar-Osorio G, Amillis S, Uchima CA, Anderluh G, Asadollahi M, Askin M, Barry K, et al. Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus. Genome Biol. 2017;18(1):28.Abstract
BACKGROUND: The fungal genus Aspergillus is of critical importance to humankind. Species include those with industrial applications, important pathogens of humans, animals and crops, a source of potent carcinogenic contaminants of food, and an important genetic model. The genome sequences of eight aspergilli have already been explored to investigate aspects of fungal biology, raising questions about evolution and specialization within this genus. RESULTS: We have generated genome sequences for ten novel, highly diverse Aspergillus species and compared these in detail to sister and more distant genera. Comparative studies of key aspects of fungal biology, including primary and secondary metabolism, stress response, biomass degradation, and signal transduction, revealed both conservation and diversity among the species. Observed genomic differences were validated with experimental studies. This revealed several highlights, such as the potential for sex in asexual species, organic acid production genes being a key feature of black aspergilli, alternative approaches for degrading plant biomass, and indications for the genetic basis of stress response. A genome-wide phylogenetic analysis demonstrated in detail the relationship of the newly genome sequenced species with other aspergilli. CONCLUSIONS: Many aspects of biological differences between fungal species cannot be explained by current knowledge obtained from genome sequences. The comparative genomics and experimental study, presented here, allows for the first time a genus-wide view of the biological diversity of the aspergilli and in many, but not all, cases linked genome differences to phenotype. Insights gained could be exploited for biotechnological and medical applications of fungi.
Vlachou M, Papamichael M, Siamidi A, Fragouli I, Afroudakis PA, Kompogennitaki R, Dotsikas Y. Comparative in vitro controlled release studies on the chronobiotic hormone melatonin from cyclodextrins-containing matrices and cyclodextrin: Melatonin complexes. International Journal of Molecular Sciences [Internet]. 2017;18. Website
Karvelis H, Kouroutzoglou J, Flocas HA, Hatzaki M, Tsiourta K, Lalos A, Keay K, Simmonds I. Comparison of the synoptic environment and mechanisms of two cases of surface cyclogenesis in Greek area associated to strong low-level cold surges. In: Karacostas T, Bais A, Nastos PT Perspectives on Atmospheric Sciences. 1st ed. Springer International Publishing; 2017. pp. 397–402.
Chatzigeorgiou P, Mourelatou A, Pollatos E, Margari D, Zogzas N, Viras K, Mavromoustakos T, Semidalas CE. Comparison of the thermal behavior and conformational changes in partially and fully hydrated dipalmitoylphosphatidylcholine systems. Journal of Thermal Analysis and Calorimetry [Internet]. 2017:1 - 12. Website
Raptopoulos G, Kyriakou K, Mali G, Scarpellini A, Anyfantis GC, Mavromoustakos T, Pitsikalis M, Paraskevopoulou P. Copolymerization of norbornene and norbornadiene using a cis-selective bimetallic W-based catalytic system. Polymers [Internet]. 2017;9(4). Website
Mazzoni D, Albanesi C, Ferreira PD, Opermann S, Pavlopoulos V, Cicognani E. Cross-border mobility, European identity and participation among European adolescents and young adults. European Journal of Developmental Psychology [Internet]. 2017:1-16. doi
Sioupouli G, Lambrinidis G, Mikros E, Amillis S, Diallinas G. Cryptic purine transporters in Aspergillus nidulans reveal the role of specific residues in the evolution of specificity in the NCS1 family. Mol Microbiol. 2017;103(2):319-332.Abstract
NCS1 proteins are H(+) or Na(+) symporters responsible for the uptake of purines, pyrimidines or related metabolites in bacteria, fungi and some plants. Fungal NCS1 are classified into two evolutionary and structurally distinct subfamilies, known as Fur- and Fcy-like transporters. These subfamilies have expanded and functionally diversified by gene duplications. The Fur subfamily of the model fungus Aspergillus nidulans includes both major and cryptic transporters specific for uracil, 5-fluorouracil, allantoin or/and uric acid. Here we functionally analyse all four A. nidulans Fcy transporters (FcyA, FcyC, FcyD and FcyE) with previously unknown function. Our analysis shows that FcyD is moderate-affinity, low-capacity, highly specific adenine transporter, whereas FcyE contributes to 8-azaguanine uptake. Mutational analysis of FcyD, supported by homology modelling and substrate docking, shows that two variably conserved residues (Leu356 and Ser359) in transmembrane segment 8 (TMS8) are critical for transport kinetics and specificity differences among Fcy transporters, while two conserved residues (Phe167 and Ser171) in TMS3 are also important for function. Importantly, mutation S359N converts FcyD to a promiscuous nucleobase transporter capable of recognizing adenine, xanthine and several nucleobase analogues. Our results reveal the importance of specific residues in the functional evolution of NCS1 transporters.
Kellici TF, Mavromoustakos T, Jendrossek D, Papageorgiou AC. Crystal structure analysis, covalent docking, and molecular dynamics calculations reveal a conformational switch in PhaZ7 PHB depolymerase. Proteins: Structure, Function and Bioinformatics [Internet]. 2017;85(7):1351 - 1361. Website
Gavriatopoulou M, Terpos E, Kastritis E, Dimopoulos MA. Current treatment options and investigational drugs for Waldenstrom’s Macroglobulinemia. Expert Opinion on Investigational Drugs [Internet]. 2017;26(2):197 - 205. WebsiteAbstract
Introduction: Waldenström’s Macroglobulinemia (WM) is a rare, indolent, incurable, low-grade B-cell lymphoplasmacytic neoplasm. This review article provides a modern clinical perspective of the individualized management of patients with symptomatic WM, in the context of the updated treatment guidelines and the currently available trial data. Areas covered: Rituximab-based regimens (such as the dexamethasone, rituximab and cyclophosphamide combination, DRC) are the most widely used in the management of both newly diagnosed and relapsed/refractory patients with WM. Recently, the Bruton’s tyrosine kinase inhibitor ibrutinib has been licensed for use in WM with exciting results. Several investigational single agent and combination regimens are being evaluated for response, efficacy and tolerability in phase II clinical trials, including new generation monoclonal antibodies (ofatumumab), immunomodulatory agents (thalidomide and lenalidomide), proteasome inhibitors (bortezomib and carfilzomib), Bruton’s tyrosine kinase inhibitors (ibrutinib and acalabrutinib), phosphoinositide 3-kinase/protein kinase B (Akt)/mammalian target of rapamycin pathway inhibitors (everolimus and perifosene), and histone deacetylase inhibitors (panobinostat) both in the setting of newly diagnosed and relapsed/refractory disease. Expert opinion: WM therapeutic approach should be individualized for each patient in accordance to the intensity of the disease characteristics, age, comorbidities, efficacy, tolerability and safety profile of each drug. © 2017 Informa UK Limited, trading as Taylor & Francis Group.
Gavriatopoulou M, Terpos E, Kastritis E, Dimopoulos MA. Current treatment options and investigational drugs for Waldenstrom’s Macroglobulinemia. Expert Opinion on Investigational Drugs [Internet]. 2017;26(2):197 - 205. WebsiteAbstract
Introduction: Waldenström’s Macroglobulinemia (WM) is a rare, indolent, incurable, low-grade B-cell lymphoplasmacytic neoplasm. This review article provides a modern clinical perspective of the individualized management of patients with symptomatic WM, in the context of the updated treatment guidelines and the currently available trial data. Areas covered: Rituximab-based regimens (such as the dexamethasone, rituximab and cyclophosphamide combination, DRC) are the most widely used in the management of both newly diagnosed and relapsed/refractory patients with WM. Recently, the Bruton’s tyrosine kinase inhibitor ibrutinib has been licensed for use in WM with exciting results. Several investigational single agent and combination regimens are being evaluated for response, efficacy and tolerability in phase II clinical trials, including new generation monoclonal antibodies (ofatumumab), immunomodulatory agents (thalidomide and lenalidomide), proteasome inhibitors (bortezomib and carfilzomib), Bruton’s tyrosine kinase inhibitors (ibrutinib and acalabrutinib), phosphoinositide 3-kinase/protein kinase B (Akt)/mammalian target of rapamycin pathway inhibitors (everolimus and perifosene), and histone deacetylase inhibitors (panobinostat) both in the setting of newly diagnosed and relapsed/refractory disease. Expert opinion: WM therapeutic approach should be individualized for each patient in accordance to the intensity of the disease characteristics, age, comorbidities, efficacy, tolerability and safety profile of each drug. © 2017 Informa UK Limited, trading as Taylor & Francis Group.
Zerefos CS, Eleftheratos K, Kapsomenakis J, Solomos S, Inness A, Balis DS, Redondas A, Eskes H, Allaart M, Amiridis V, et al. Detecting volcanic sulfur dioxide plumes in the Northern Hemisphere using the Brewer spectrophotometers, other networks, and satellite observations. Atmospheric Chemistry and Physics [Internet]. 2017;17:551-574. Publisher's Version a30_acp_2017.pdf
Vrontaki E, Melagraki G, Voskou S, Phylactides MS, Mavromoustakos T, Kleanthous M, Afantitis A. Development of a predictive pharmacophore model and a 3D-QSAR study for an in Silico screening of new potent BCR-ABL kinase inhibit. Mini-Reviews in Medicinal Chemistry [Internet]. 2017;17(3):188 - 204. Website
Farangitakis G, Christopoulou A, Vassilakis Ε, Papanikolaou I, Arianoutsou Μ. Do landscape properties affect the process of post-fire vegetation recovery? A case study from the Taygetos Mountain, Greece. In: XIV MEDECOS & XIII AEET meeting. Seville, Spain; 2017. pp. 114. posterAbstract
Fires of 2007 have consumed large areas of Black pine and endemic fir forests in Greece. The current research aims at examining the role of geomorphology and lithology that govern the soil properties upon the post-fire vegetation recovery at the landscape level. A case study from Taygetos Mt, a large part of which was burned in 2007, is presented. Based on the interpretation of a high spatial and spectral resolution satellite image (WorldView-3, 4/2015), GIS thematic layers have been created showing unburned and regenerated patches over various lithological types. A network of sites was selected for field sampling representing various combinations of the above. Data on recovery of the main tree species as well as on total vegetation cover were collected. Results prove the relationship between regeneration ability and plant species traits as well as the existence of unburned patches near the burned ones. Black pine had regenerated from seeds dispersed from cones that have remained intact on unburned or scorched trees, close enough to the burned patches, while Greek fir presented remarkably low regeneration, lacking of any response mechanism. Plant species recovery seems to be controlled by the geology as it was found weaker in plots overlying carbonate, permeable, not easily erodible formations as compared to that observed over clastic, impermeable, erodible formations of schists, even for the same species. In conclusion, post-fire vegetation recovery at the landscape level seems to be a complex process controlled not only from species biology but also from the landscape features.
Misiakos EP, Bagias G, Papadopoulos I, Danias N, Patapis P, Machairas N, Karatzas T, Arkadopoulos N, Toutouzas K, Alexakis N, et al. Early Diagnosis and Surgical Treatment for Necrotizing Fasciitis: A Multicenter Study. Frontiers in Surgery [Internet]. 2017;4:5. WebsiteAbstract
Background: Necrotizing fasciitis (NF) is a group of relatively rare infections, usually caused by two or more pathogens. It affects the skin and subcutaneous tissues of lower and upper limbs, perineal area (Fournier’s gangrene) and the abdominal wall. Early diagnosis and aggressive surgical management are of high significance for the management of this potentially lethal disease. Methods: We conducted a retrospective study in patients who presented,during the last decade,at four University Surgical Departments in the area of Athens, Greece, with an admission diagnosis of NF. Demographic, clinical and laboratory data were gathered, and the preoperative and surgical treatment, as well as the postoperative treatment was analyzed for these patients. Results: A total of 62 patients were included in the study. The mean age of patients was 63.7 (47 male patients). Advanced age (over 65 years) (P<0.01) and female sex (P=0.04) correlated significantly with mortality. Perineum was the mostly infected site (46.8%), followed by the lower limbs (35.5%), and the upper limbs and the axillary region (8.1%). Diabetes mellitus was the most common co-existing disease (40.3%), followed by hypertension (25.8%) and obesity (17,7%). The most common symptom was local pain and tenderness (90.3%). Septic shock occurred in 8 patients (12.9%), and strongly correlated with mortality (P<0.01). Laboratory data were used to calculate retrospectively the LRINEC score of every patient; 26 patients (41.9%) had LRINEC score under 6, 20 patients (32.3%) had LRINEC score 6-8 and 16 patients (25.8%) had LRINEC score >9. Surgical debridement was performed in all patients (mean no. of repeated debridement 4.8), and in 16 cases (25.8%) the infected limb was amputated. The mean length of hospital stay was 19.7 days, and the overall mortality rate of our series was 17.7%. Conclusions: Diagnosis of NF requires high suspect among clinicians, as its clinical image is non-specific. Laboratory tests can depict the severity of the disease; therefore they must be carefully evaluated. Urgent surgical debridement is the mainstay of treatment in all patients; the need of repetitive surgical debridement is undisputed.
Diakakis M, Nikolopoulos EI, Mavroulis S, Vassilakis E, Korakaki E. The effect of large forest fires on floods and landslides. The case of the 2007 fires in Ileia, Greece. Safe Athens 2017. 2017.Abstract
Although forest fires are considered an integral part of Mediterranean forest ecosystems, they nevertheless constitute one of the most devastating natural hazards. Apart from the direct consequences, fires induce longer term effects in the geomorphological and hydrological processes, influencing environmental factors that in turn can affect the occurrence of other natural hazards, such as floods and mass movement phenomena. This work focuses on the forest fire of 2007 in Peloponnese, Greece that burnt 1773 km2, causing 78 fatalities and very significant damages in property and infrastructure and went down as the largest fire in the country’s record. It examines the occurrence of flood and mass movement phenomena, before and after this mega-fire and studies different influencing factors to investigate the degree to which the 2007 fire and/or other parameters have affected their frequency.Observational evidence based on several data sources collected during the period 1989-2016 show that the 2007 fire has contributed to an increase of average flood and mass movement events frequency by approximately 3.3 and 5.6 times respectively. Fire affected areas record a substantial increase in the occurrence of both phenomena, presenting a noticeably stronger increase compared to neighbouring areas that have not been affected. Examination of the monthly occurrence of events showed an increase even in months of the year were rainfall intensity presented decreasing trends. Although no major land use changes has been identified and chlorophyll is shown to recover 2 years after the fire incident, differences on the type of vegetation as tall forest has been substituted with lower vegetation are considered significant drivers for the observed changes in hydrogeomorphic response of the fire affected basins.
Stefi AL, Margaritis LH, Christodoulakis NS. The effect of the non ionizing radiation on exposed, laboratory cultivated upland cotton (Gossypium hirsutum L.) plants. Flora: Morphology, Distribution, Functional Ecology of Plants [Internet]. 2017;226:55 - 64. WebsiteAbstract
A series of experiments was carried out to investigate possible structural or biochemical alterations in Gossypium hirsutum plants after a long term (21 days) exposure to non ionizing radiation (1882 MHz) emitted from the base unit of a cordless DECT system. Exposed plants, compared to the negative (matched) controls, seem to be seriously affected. Notably lower biomass production for the above ground part and the root was recorded. Reduction of the photosynthetic pigments and severe damage of the chloroplast structure were also observed. It seems that non ionizing radiation can be noxious for plant life functions. © 2016 Elsevier GmbH
Foufopoulos J, Roca V, White KA, Pafilis P, Valakos ED. Effects of island characteristics on parasitism in a Mediterranean lizard (Podarcis erhardii): A role of population size and island history?. North-Western Journal of Zoology [Internet]. 2017;13(1):70 - 76. Website
Diakakis M, Nikolopoulos E, Mavroulis S, Emm. V, Korakaki E. The effects of the 2007 Peloponnese forest fires in rainfall-triggered, flood and mass movement phenomena. A 10-years lasting impact. In: 11th Intern. Hydrogeological Conference. Athens; 2017.Abstract
Apart from direct consequences, forest fires induce water related effects related to geomorphological and hydrological processes, triggering floods and mass movement phenomena. This work focuses on the forest fire of 2007 in Peloponnese, Greece that to date corresponds to the largest fire in the country’s record. It examines the occurrence of flood and mass movement phenomena, before and after this fire and analyses different influencing factors to investigate the degree to which the 2007 fire and/or other parameters have affected their frequency. Observational evidence collected during the period 1989-2016 show that the 2007 fire has contributed to an increase of average flood and mass movement events frequency by approximately 3.3 and 5.6 times respectively. Fire affected areas record a substantial increase in the occurrence of both phenomena, presenting a noticeably stronger increase compared to neighbouring areas that have not been affected. Examination of the monthly occurrence of events showed an increase even in months of the year were rainfall intensity presented decreasing trends. Although no major land use changes has been identified and chlorophyll is shown to recover 2 years after the fire incident, differences on the type of vegetation as tall forest has been substituted with lower vegetation are considered significant drivers for the observed increase in flood and mass movement frequency in the fire affected areas.
Chatoupis C, Vagenas G. Effects of two practice style formats on fifth grade students motor skill performance and task engagement. The Physical Educator [Internet]. 2017;74(2):220. Publisher's VersionAbstract
We investigated the effectiveness of two teaching formats that fall under the canopy of Mosston and Ashworth’s (2008) practice style, on fifth grade students’ motor skill performance and task engagement. Both formats are also known as station teaching or learning centers. In the teacher-rotated format (TR), the teacher decides the amount of time apportioned during practice at each station, whereas in the learner-rotated format (LR), each learner decides on task order and the amount of time spent at each station. Ten-year-old children (N = 60) were randomly assigned to the TR group (n = 20), the LR group (n = 25), and a control group (n = 15). A soccer dribbling test was employed to evaluate the soccer dribbling skill prior to and after the instructional intervention. The same soccer dribbling tasks were taught to the learners in both treatment groups in eight 30-min sessions. ANCOVA on the posttest scores showed a significant difference between the experimental groups and the control group (p < .001) and between the two experimental groups, favoring the LR group (p < .001). A 3 × 2 (Group × Test) repeated measures ANOVA showed a significant improvement of the soccer dribbling skill for both teaching formats (p < .001) but not for the control group. An ANOVA on the overall practice trial data yielded significant differences between the two formats, favoring the LR group (p < .001). Both formats were found to be effective, but the results indicate that given the opportunity to reapportion their practice time, learners in the LR format took advantage of this opportunity and improved their performance further.
Gavriatopoulou M, Terpos E, Kastritis E, Dimopoulos MA. Efficacy and safety of elotuzumab for the treatment of multiple myeloma. Expert Opinion on Drug Safety [Internet]. 2017;16(2):237 - 245. WebsiteAbstract
Introduction: Multiple myeloma (MM) is the second most common hematologic malignancy and despite significant outcome improvements with novel agents, the majority of patients will eventually relapse and develop treatment resistance. Immunotherapy is emerging as a promising therapeutic approach in MM. Areas covered: Elotuzumab is a monoclonal antibody directly targeting the SLAMF7 receptor, expressed on normal and malignant plasma cells. Elotuzumab has no meaningful antimyeloma activity when given as monotherapy to patients with relapsed or refractory MM (RRMM). However, it demonstrated significant antimyeloma activity in preclinical studies and when it is combined with other antimyeloma agents (i.e. bortezomib or lenalidomide) in clinical trials, it improved response and clinical outcomes with no additive toxicity. This review provides a brief description of the elotuzumab mechanism of action and an overview on its efficacy in preclinical and clinical trials, including its safety and toxicity profile. Expert commentary: Based on the results of a phase 3 clinical trial (ELOQUENT-2), which compared lenalidomide and dexamethasone with or without elotuzumab in patients with RRMM, elotuzumab was approved by FDA in November 2015 for MM patients who received 1–3 prior lines of therapy. Studies with combinations of elotuzumab with other anti-myeloma drugs in different phases of MM are ongoing. © 2017 Informa UK Limited, trading as Taylor & Francis Group.
Gavriatopoulou M, Terpos E, Kastritis E, Dimopoulos MA. Efficacy and safety of elotuzumab for the treatment of multiple myeloma. Expert Opinion on Drug Safety [Internet]. 2017;16(2):237 - 245. WebsiteAbstract
Introduction: Multiple myeloma (MM) is the second most common hematologic malignancy and despite significant outcome improvements with novel agents, the majority of patients will eventually relapse and develop treatment resistance. Immunotherapy is emerging as a promising therapeutic approach in MM. Areas covered: Elotuzumab is a monoclonal antibody directly targeting the SLAMF7 receptor, expressed on normal and malignant plasma cells. Elotuzumab has no meaningful antimyeloma activity when given as monotherapy to patients with relapsed or refractory MM (RRMM). However, it demonstrated significant antimyeloma activity in preclinical studies and when it is combined with other antimyeloma agents (i.e. bortezomib or lenalidomide) in clinical trials, it improved response and clinical outcomes with no additive toxicity. This review provides a brief description of the elotuzumab mechanism of action and an overview on its efficacy in preclinical and clinical trials, including its safety and toxicity profile. Expert commentary: Based on the results of a phase 3 clinical trial (ELOQUENT-2), which compared lenalidomide and dexamethasone with or without elotuzumab in patients with RRMM, elotuzumab was approved by FDA in November 2015 for MM patients who received 1–3 prior lines of therapy. Studies with combinations of elotuzumab with other anti-myeloma drugs in different phases of MM are ongoing. © 2017 Informa UK Limited, trading as Taylor & Francis Group.
Estudios y Homenajes Hispanoamericanos V. 1st ed. (Pavlakis EP, Symeonidis H, Pajovic S, Drosos DL, Chandler PM, Papageorgíou A, Kritikou V). Madrid: Ediciones del Orto; 2017 pp. 370. Publisher's Version
Estudios y Homenajes Hispanoamericanos V. 1st ed. (Pavlakis EP, Symeonidis H, Pajovic S, Drosos DL, Chandler PM, Papageorgíou A, Kritikou V). Madrid: Ediciones del Orto; 2017 pp. 370. Publisher's Version
Kritikou V. Santa de Federico Gamboa en su contexto histórico y social. In: Leopoldo Zea. Aproximación a la figura del filósofo mexicano. 1st ed. Madrid: Ediciones del Orto; 2017. pp. 91-102. santa-contexto_historico_social.pdf
Ἰσαῖος. Περὶ τοῦ Πύρρου κλήρου. Εἰσαγωγή, κείμενο, μετάφραση, ἑρμηνευτικὸ ὑπόμνημα. Αθήνα: Ακαδημία Αθηνών; 2017.
Pietri P, Papaioannou T, Stefanadis C. Environment: An old clue to the secret of longevity. Nature. 2017;544(7651):416.
Wagner B, Wilke T, Franke A, Albrecht C, Baumgarten H, Bertini A, Combourieu-Nebout N, Cvetkoska A, D'Addabbo M, Donders TH, et al. The environmental and evolutionary history of Lake Ohrid (FYROM/Albania): interim results from the SCOPSCO deep drilling project. Biogeosciencs [Internet]. 2017;14:2033-2054. Publisher's VersionAbstract
This study reviews and synthesises existing information generated within the SCOPSCO (Scientific Collaboration on Past Speciation Conditions in Lake Ohrid) deep drilling project. The four main aims of the project are to infer (i) the age and origin of Lake Ohrid (Former Yugoslav Republic of Macedonia/Republic of Albania), (ii) its regional seismotectonic history, (iii) volcanic activity and climate change in the central northern Mediterranean region, and (iv) the influence of major geological events on the evolution of its endemic species. The Ohrid basin formed by transtension during the Miocene, opened during the Pliocene and Pleistocene, and the lake established de novo in the still relatively narrow valley between 1.9 and 1.3 Ma. The lake history is recorded in a 584 m long sediment sequence, which was recovered within the framework of the International Continental Scientific Drilling Program (ICDP) from the central part (DEEP site) of the lake in spring 2013. To date, 54 tephra and cryptotephra horizons have been found in the upper 460 m of this sequence. Tephrochronology and tuning biogeochemical proxy data to orbital parameters revealed that the upper 247.8 m represent the last 637 kyr. The multi-proxy data set covering these 637 kyr indicates long-term variability. Some proxies show a change from generally cooler and wetter to drier and warmer glacial and interglacial periods around 300 ka. Short-term environmental change caused, for example, by tephra deposition or the climatic impact of millennial-scale Dansgaard–Oeschger and Heinrich events are superimposed on the long-term trends. Evolutionary studies on the extant fauna indicate that Lake Ohrid was not a refugial area for regional freshwater animals. This differs from the surrounding catchment, where the mountainous setting with relatively high water availability provided a refuge for temperate and montane trees during the relatively cold and dry glacial periods. Although Lake Ohrid experienced significant environmental change over the last 637 kyr, preliminary molecular data from extant microgastropod species do not indicate significant changes in diversification rate during this period. The reasons for this constant rate remain largely unknown, but a possible lack of environmentally induced extinction events in Lake Ohrid and/or the high resilience of the ecosystems may have played a role.
Liossi AS, Ntountaniotis D, Kellici TF, Chatziathanasiadou MV, Megariotis G, Mania M, Becker-Baldus J, Kriechbaum M, Krajnc A, Christodoulou E, et al. Exploring the interactions of irbesartan and irbesartan–2-hydroxypropyl-β-cyclodextrin complex with model membranes. Biochimica et Biophysica Acta - Biomembranes [Internet]. 2017;1859(6):1089 - 1098. Website
Liapakis G, Matsoukas M-T, Karageorgos V, Venihaki M, Mavromoustakos T. Family B G protein-coupled receptors and their ligands: From structure to function. Current Medicinal Chemistry [Internet]. 2017;24(31):3323 - 3355. Website
Revithiadou A, Spyropoulos V, Markopoulos G. From fusion to agglutination: The case of Asia Minor Greek. Transactions of the Philological Society. 2017;115(3):297-335.Abstract
This article examines the nominal inflectional system of a group of Asia Minor Greek dialects (Dawkins 1910, 1916), which developed, in parallel with the fusional inflectional system, an agglutinative one due to language contact with Turkish. We argue that the ‘old’ fusional ending or the theme vowel was reanalyzed as part of the nominal stem. This novel structure was actualized by means of two competing options: in some dialects, the reanalysis was actualized transparently in all inflectional forms rendering an agglutinative pattern of inflection, whereas in dialects with limited agglutination the actualization took the form of a special type of vowel assimilation. More specifically, as part of the nominal stem, the ‘old’ theme vowel signals its merge with the root by allowing it to absorb some or all of its features. Formally, the phonological process is treated as an instance of indirect licensing (Walker 2011), according to which the theme vowel acts as a trigger due to its privileged position as a segment of the categorizer n, i.e. the head of the stem.
Kamberidou I. Gender, Volunteerism and Military Hospitals: War Nurses, Educators and Philanthropists of the Nineteenth-Century. The 14th ERGOMAS Conference: Military and Society: New Models for New Challenges, Working Group “Gender and the Military”. 2017:98-99.Abstract
Thousands of European and American women provided their services, lobbied, raised funds, food supplies and clothing to support the Greek Revolution.  Along with the relief activities of the 1820’s and 1830’s, the great interest in Greece produced a strong desire to send teachers and missionaries to Greece in Bondage.  Women’s 19th century accounts examine the position of the subjugated Greeks in the Aegean Islands and Asia Minor. European and American women—educators and philanthropists—worked for the advancement of female education. They even established schools for the preservation of Hellenic cultural heritage. This paper focuses on the first-hand accounts of 19th century European aristocratic and middle-class women volunteers, and specifically their social contribution during the Crimean War (1853-1856), when the English and French colonial experience encouraged female volunteerism. It spotlights the social service provided by English, French and German nurses and philanthropists—as agents of social change—who cared for the soldiers in the hospitals of Constantinople and its environs, concluding with their invaluable recommendations. The female accounts describe the British military and naval hospitals, hospital huts, nurses duties and difficulties confronted (1,500 patients per 3 volunteers); the Women’s Hospital; the French hospitals; the French military system; the Sisters of Mercy; the Sisters of Charity; the women who followed their husbands to war, including the destitute wives and babies of the English soldiers. Astonishing are the accounts concerning the degrading social status of the English soldier’s wife as opposed to the respect and protection enjoyed by the French soldier’s wife.  
letter_of_acceptance_gender_volunteerism_and_military_hospitals_war_nurses_educators.pdf ergomas_program_full_27_march_2017_ver.1_with_out_abstract.docx abstracts_pp._98-99._ergomas_program_full_17_may_2017._final_program.docx gender_volunteerism_and_military_hospitals.pdf
Gouliotis L, Foumelis M, Vassilakis E, Papanikolaou D, Pavlopoulos K. Geologic, Geomorphic and Geodetic Constraints on Vertical Motion Trends of Itea-Amfissa Basin (Northern Corinth Rift, Central Greece). In: EGU2017-6766. Vol. 19. Vienna, Austria; 2017.Abstract
Combining geological and geomorphological data together with geodetic SAR interferometry (InSAR) measurements an attempt has been made to investigate the vertical deformation of the Itea-Amfissa basin at the northern part of the Corinth rift. The north–south trending basin has been developed normally to the east – west trending Corinth Rift and on the hanging wall of the Itea-Amfissa detachment. In the stratigraphy of the Itea–Amfissa supra-detachment basin, two sequences can be distinguished; the lower marine polymict conglomerate of Early–Middle Miocene age and the upper terrestrial monomict carbonate breccia of Late Miocene age. The unconformity between them has been uplifted to the north of the basin up to the elevation of 1100m and subsided below sea level at its southern part. Remnants of low-relief surfaces are retained on top of the upper terrestrial sequence, that permit to reconstruct the paleo-landscape of the basin and to measure the spatial distribution of its vertical deformation after compensating the erosional isostatic adjustment. The exact delineation of the paleo-landscape, involved detailed mapping as well as quantitative analysis of geomorphological features caused by river incision, based on measurements of several tectonic geomorphology indices. Geodetic InSAR estimates of vertical ground displacements, combining almost 10 years of ascending and descending ENVISAT data, were also utilized both for refinement of delineated surfaces as well as for validation of geology-based deformation trends. Interferometric results were constrained to the geologic time frame, considering the well-defined long-term deformation trend of a doline, proven to be sinking over the last 6000 years. It is shown that over the last 10 years the largest uplift rates are observed within the Itea-Amfissa basin, while the coastline regions follow a more complex spatial deformation pattern of successive submergences and uplifts. The synthesis of geological and geomorphological data indicates that the Itea-Amfissa extensional basin from its development in the Middle-Late Miocene and throughout Plio-Quaternary, has been tilted towards south, while contemporary geodetic measurements from InSAR confirm that the basin is still uplifting with regard to its surrounding mountains and coastal areas.  
Mazis I. Geopolitical analysis of the Russo-American energy antagonism in the sub-system of the Balkans, in the greater system of the Mediterranean. Civitas Gentium [Internet]. 2017;5(4):27-34. Publisher's VersionAbstract
Greece has the ambiguous privilege of forming the intersection of two unstable Sub-systems of the Mediterranean Geopolitical Complex, i.e.: i. the Sub-system of the Balkans and ii. the Sub-system of Turkey and the Near East. We shall demonstrate that these two Sub-systems feature an intense joint function of instability in the present juncture and we shall also emphasize the main Geopolitical Factor that causes the aforementioned instability, i.e. energy security. Furthermore, we shall lay emphasis on the new Cold War-style antagonism between the two fundamental Poles of International Power, i.e. Moscow and Washington, an  antagonism  affecting  in  a  destabilizing  manner  the  Geopolitical  Complex  of  the  Mediterranean and in the Western Balkans regions as a main focal point. The term new Cold War-style is used so as to highlight the fact that there exists a considerable ideological distance between these two Poles (the same applies albeit in a different manner for the relations between Washington and Beijing), as was the case during the Cold War. The ideological difference in this case consists of the contrast between the neoliberal Western approach and the identitarian conservative approach of the East spearheaded by Moscow. Our analysis is based on the classic Anglo-Saxon geopolitical school and especially on N.J. Spykman’s «containment model», as the latter has been modified by Z. Brzesinsky. Our methodological approach is based on Systemic Geopolitical Analysis.
79-1-275-1-10-20171227.pdf
Mazis I. Geopolitics and contemporary international reality: knowledge, interpretation and prediction. Civitas Gentium [Internet]. 2017;5(4):21-26. Publisher's VersionAbstract
Knowledge of the geopolitical reality has been, is and shall be a challenge for political and spiritual leadership. The dominant actors in the globe are equipped with notable centers of research and study concerning the geopolitical reality. In this manner and taking into account the geopolitical models that derive from research they are able to plan their relative hegemonic or dominant international strategies. The current reality, though, is characterized by a tendency of revision concerning those traditional hermeneutic models of the Cold War period, a period during which known and ‘safe’ answers were provided for all social, political, economic and philosophical matters. These traditional ‘holistic’ models, which were applied on specifi c state actors and groups of state actors, were two: i) the socialist model and its dialectic opposite, ii) the liberal model. These two philosophical and ideological axes were complemented by the geopolitical model created by Nicholas J. Spykman (1893-1943), according to which there occurs a worldwide antagonism between Land Powers (Warsaw Pact, Soviet Union and satellite states) and Sea Powers (US, Great Britain, Japan, NATO and satellite states). This division led to the geopolitical, ideological, defensive, economic and therefore geostrategic alignment of the participating states into two clashing worlds, i.e. the Eastern and the Western world. This dominant division was adopted by the relevant elites of the various state actors that were part of the international structures of the International Power Poles. This phenomenon was prevalent throughout the 20th century and was manifested also in the relevant political cultures, dominant ideologies, as well as in the geostrategic approaches of the aforementioned International Power Poles and their respective satellites.
78-1-273-1-10-20171227.pdf
Mitsi E. “Greece ‘Digested in a Play’: Consuming Greek Heroism in The School of Abuse and Troilus and Cressida”. In: Shakespeare and Greece, ed. Alison Findlay and Vassiliki Markidou. Arden Bloomsbury; 2017. pp. 93-115.
Mitsi E. Greece in Early English Travel Writing, 1586-1682. Palgrave Macmillan; 2017. Publisher's VersionAbstract
This book examines the letters, diaries, and published accounts of English and Scottish travelers to Greece in the seventeenth century, a time of growing interest in ancient texts and the Ottoman Empire. Through these early encounters, this book analyzes the travelers’ construction of Greece in the early modern Mediterranean world and shows how travel became a means of collecting and disseminating knowledge about ancient sites. Focusing on the mobility and exchange of people, artifacts, texts, and opinions between the two countries, it argues that the presence of Britons in Greece and of Greeks in England aroused interest not only in Hellenic antiquity, but also in Greece’s contemporary geopolitical role. Exploring myth, perception, and trope with clarity and precision, this book offers new insight into the connections between Greece, the Ottoman Empire, and the West.
Minnema MC, Kimby E, D’Sa S, Fornecker L-M, Poulain S, Snijders TJ, Kastritis E, Kremer S, Fitsiori A, Simon L, et al. Guideline for the diagnosis, treatment and response criteria for Bing-Neel syndrome. Haematologica [Internet]. 2017;102(1):43 - 51. WebsiteAbstract
Bing Neel syndrome is a rare disease manifestation of Waldenström’s macroglobulinemia that results from infiltration of the central nervous system by malignant lymphoplasmacytic cells. In this guideline we describe the clinical symptoms, as well as the appropriate laboratory and radiological studies, that can aid in the diagnosis. The presentation of Bing Neel syndrome may be very diverse, and includes headaches, cognitive deficits, paresis, and psychiatric symptoms. The syndrome can present in patients with known Waldenström’s macroglobulinemia, even in the absence of systemic progression, but also in previously undiagnosed patients. Diagnostic work-up should include cerebral spinal fluid analysis with multiparameter flow cytometry to establish B-cell clonality, protein electrophoresis and immunofixation for the detection and classification of a monoclonal protein as well as molecular diagnostic testing for immunoglobulin gene rearrangement and mutated MYD88. MRI of the brain and spinal cord is also essential. The second challenge is to expand our knowledge of prognosis and treatment outcome. Prospective clinical trials on Bing Neel syndrome patients that employ uniform treatment along with appropriate laboratory cerebral spinal fluid assessments and standardized MRI protocols will be invaluable, constituting a significant step forward in delineating treatment outcome for this intriguing disease manifestation. © 2017 Ferrata Storti Foundation.
Minnema MC, Kimby E, D’Sa S, Fornecker L-M, Poulain S, Snijders TJ, Kastritis E, Kremer S, Fitsiori A, Simon L, et al. Guideline for the diagnosis, treatment and response criteria for Bing-Neel syndrome. Haematologica [Internet]. 2017;102(1):43 - 51. WebsiteAbstract
Bing Neel syndrome is a rare disease manifestation of Waldenström’s macroglobulinemia that results from infiltration of the central nervous system by malignant lymphoplasmacytic cells. In this guideline we describe the clinical symptoms, as well as the appropriate laboratory and radiological studies, that can aid in the diagnosis. The presentation of Bing Neel syndrome may be very diverse, and includes headaches, cognitive deficits, paresis, and psychiatric symptoms. The syndrome can present in patients with known Waldenström’s macroglobulinemia, even in the absence of systemic progression, but also in previously undiagnosed patients. Diagnostic work-up should include cerebral spinal fluid analysis with multiparameter flow cytometry to establish B-cell clonality, protein electrophoresis and immunofixation for the detection and classification of a monoclonal protein as well as molecular diagnostic testing for immunoglobulin gene rearrangement and mutated MYD88. MRI of the brain and spinal cord is also essential. The second challenge is to expand our knowledge of prognosis and treatment outcome. Prospective clinical trials on Bing Neel syndrome patients that employ uniform treatment along with appropriate laboratory cerebral spinal fluid assessments and standardized MRI protocols will be invaluable, constituting a significant step forward in delineating treatment outcome for this intriguing disease manifestation. © 2017 Ferrata Storti Foundation.
Mari S, Volpato C, Papastamou S, Chryssochoou X, Prodromitis G, Pavlopoulos V. How political orientation and vulnerability shape representations of the economic crisis in Greece and Italy. International Review of Social Psychology [Internet]. 2017;30(1). doi
Dimopoulos MA, Trotman J, Tedeschi A, Matous JV, Macdonald D, Tam C, Tournilhac O, Ma S, Oriol A, Heffner LT, et al. Ibrutinib for patients with rituximab-refractory Waldenström's macroglobulinaemia (iNNOVATE): an open-label substudy of an international, multicentre, phase 3 trial. The Lancet Oncology [Internet]. 2017;18(2):241 - 250. WebsiteAbstract
Background In the era of widespread rituximab use for Waldenström's macroglobulinaemia, new treatment options for patients with rituximab-refractory disease are an important clinical need. Ibrutinib has induced durable responses in previously treated patients with Waldenström's macroglobulinaemia. We assessed the efficacy and safety of ibrutinib in a population with rituximab-refractory disease. Methods This multicentre, open-label substudy was done at 19 sites in seven countries in adults aged 18 years and older with confirmed Waldenström's macroglobulinaemia, refractory to rituximab and requiring treatment. Disease refractory to the last rituximab-containing therapy was defined as either relapse less than 12 months since last dose of rituximab or failure to achieve at least a minor response. Key exclusion criteria included: CNS involvement, a stroke or intracranial haemorrhage less than 12 months before enrolment, clinically significant cardiovascular disease, hepatitis B or hepatitis C viral infection, and a known bleeding disorder. Patients received oral ibrutinib 420 mg once daily until progression or unacceptable toxicity. The substudy was not prospectively powered for statistical comparisons, and as such, all the analyses are descriptive in nature. This study objectives were the proportion of patients with an overall response, progression-free survival, overall survival, haematological improvement measured by haemoglobin, time to next treatment, and patient-reported outcomes according to the Functional Assessment of Cancer Therapy-Anemia (FACT-An) and the Euro Qol 5 Dimension Questionnaire (EQ-5D-5L). All analyses were per protocol. The study is registered at ClinicalTrials.gov, number NCT02165397, and follow-up is ongoing but enrolment is complete. Findings Between Aug 18, 2014, and Feb 18, 2015, 31 patients were enrolled. Median age was 67 years (IQR 58–74); 13 (42%) of 31 patients had high-risk disease per the International Prognostic Scoring System Waldenström Macroglobulinaemia, median number of previous therapies was four (IQR 2–6), and all were rituximab-refractory. At a median follow-up of 18·1 months (IQR 17·5–18·9), the proportion of patients with an overall response was 28 [90%] of 31 (22 [71%] of patients had a major response), the estimated 18 month progression-free survival rate was 86% (95% CI 66–94), and the estimated 18 month overall survival rate was 97% (95% CI 79–100). Baseline median haemoglobin of 10·3 g/dL (IQR 9·3–11·7) increased to 11·4 g/dL (10·9–12·4) after 4 weeks of ibrutinib treatment and reached 12·7 g/dL (11·8–13·4) at week 49. A clinically meaningful improvement from baseline in FACT-An score, anaemia subscale score, and the EQ-5D-5L were reported at all post-baseline visits. Time to next treatment will be presented at a later date. Common grade 3 or worse adverse events included neutropenia in four patients (13%), hypertension in three patients (10%), and anaemia, thrombocytopenia, and diarrhoea in two patients each (6%). Serious adverse events occurred in ten patients (32%) and were most often infections. Five (16%) patients discontinued ibrutinib: three due to progression and two due to adverse events, while the remaining 26 [84%] of patients are continuing ibrutinib at the time of this report. Interpretation The sustained responses and median progression-free survival time, combined with a manageable toxicity profile observed with single-agent ibrutinib indicate that this chemotherapy-free approach is a potential new treatment choice for patients who had heavily pretreated, rituximab-refractory Waldenström's macroglobulinaemia. Funding Pharmacyclics LLC, an AbbVie Company. © 2017 Elsevier Ltd
Dimopoulos MA, Trotman J, Tedeschi A, Matous JV, Macdonald D, Tam C, Tournilhac O, Ma S, Oriol A, Heffner LT, et al. Ibrutinib for patients with rituximab-refractory Waldenström's macroglobulinaemia (iNNOVATE): an open-label substudy of an international, multicentre, phase 3 trial. The Lancet Oncology [Internet]. 2017;18(2):241 - 250. WebsiteAbstract
Background In the era of widespread rituximab use for Waldenström's macroglobulinaemia, new treatment options for patients with rituximab-refractory disease are an important clinical need. Ibrutinib has induced durable responses in previously treated patients with Waldenström's macroglobulinaemia. We assessed the efficacy and safety of ibrutinib in a population with rituximab-refractory disease. Methods This multicentre, open-label substudy was done at 19 sites in seven countries in adults aged 18 years and older with confirmed Waldenström's macroglobulinaemia, refractory to rituximab and requiring treatment. Disease refractory to the last rituximab-containing therapy was defined as either relapse less than 12 months since last dose of rituximab or failure to achieve at least a minor response. Key exclusion criteria included: CNS involvement, a stroke or intracranial haemorrhage less than 12 months before enrolment, clinically significant cardiovascular disease, hepatitis B or hepatitis C viral infection, and a known bleeding disorder. Patients received oral ibrutinib 420 mg once daily until progression or unacceptable toxicity. The substudy was not prospectively powered for statistical comparisons, and as such, all the analyses are descriptive in nature. This study objectives were the proportion of patients with an overall response, progression-free survival, overall survival, haematological improvement measured by haemoglobin, time to next treatment, and patient-reported outcomes according to the Functional Assessment of Cancer Therapy-Anemia (FACT-An) and the Euro Qol 5 Dimension Questionnaire (EQ-5D-5L). All analyses were per protocol. The study is registered at ClinicalTrials.gov, number NCT02165397, and follow-up is ongoing but enrolment is complete. Findings Between Aug 18, 2014, and Feb 18, 2015, 31 patients were enrolled. Median age was 67 years (IQR 58–74); 13 (42%) of 31 patients had high-risk disease per the International Prognostic Scoring System Waldenström Macroglobulinaemia, median number of previous therapies was four (IQR 2–6), and all were rituximab-refractory. At a median follow-up of 18·1 months (IQR 17·5–18·9), the proportion of patients with an overall response was 28 [90%] of 31 (22 [71%] of patients had a major response), the estimated 18 month progression-free survival rate was 86% (95% CI 66–94), and the estimated 18 month overall survival rate was 97% (95% CI 79–100). Baseline median haemoglobin of 10·3 g/dL (IQR 9·3–11·7) increased to 11·4 g/dL (10·9–12·4) after 4 weeks of ibrutinib treatment and reached 12·7 g/dL (11·8–13·4) at week 49. A clinically meaningful improvement from baseline in FACT-An score, anaemia subscale score, and the EQ-5D-5L were reported at all post-baseline visits. Time to next treatment will be presented at a later date. Common grade 3 or worse adverse events included neutropenia in four patients (13%), hypertension in three patients (10%), and anaemia, thrombocytopenia, and diarrhoea in two patients each (6%). Serious adverse events occurred in ten patients (32%) and were most often infections. Five (16%) patients discontinued ibrutinib: three due to progression and two due to adverse events, while the remaining 26 [84%] of patients are continuing ibrutinib at the time of this report. Interpretation The sustained responses and median progression-free survival time, combined with a manageable toxicity profile observed with single-agent ibrutinib indicate that this chemotherapy-free approach is a potential new treatment choice for patients who had heavily pretreated, rituximab-refractory Waldenström's macroglobulinaemia. Funding Pharmacyclics LLC, an AbbVie Company. © 2017 Elsevier Ltd
Vavuranakis M, Lavda M, Vrachatis D, Papaioannou TG, Kalogeras K, Kolokathis A-M, Kariori M, Lilly S, Siasos G, Oikonomou E, et al. Impact of balloon aortic valvuloplasty on transcatheter aortic valve implantation with self-expandable valve. Journal of Cardiology [Internet]. 2017;69(1):245 - 252. Website
Moreau P, Joshua D, Chng W-J, Palumbo A, Goldschmidt H, Hájek R, Facon T, Ludwig H, Pour L, Niesvizky R, et al. Impact of prior treatment on patients with relapsed multiple myeloma treated with carfilzomib and dexamethasone vs bortezomib and dexamethasone in the phase 3 ENDEAVOR study. Leukemia [Internet]. 2017;31(1):115 - 122. WebsiteAbstract
The randomized phase 3 ENDEAVOR study (N=929) compared carfilzomib and dexamethasone (Kd) with bortezomib and dexamethasone (Vd) in relapsed multiple myeloma (RMM). We performed a subgroup analysis from ENDEAVOR in patients categorized by number of prior lines of therapy or by prior treatment. Median progression-free survival (PFS) for patients with one prior line was 22.2 months for Kd vs 10.1 months for Vd, and median PFS for patients with ≥2 prior lines was 14.9 months for Kd vs 8.4 months for Vd. For patients with prior bortezomib exposure, the median PFS was 15.6 months for Kd vs 8.1 months for Vd, and for patients with prior lenalidomide exposure the median PFS was 12.9 months for Kd vs 7.3 months for Vd. Overall response rates (Kd vs Vd) were 81.9 vs 65.5% (one prior line), 72.0 vs 59.7% (≥2 prior lines), 71.2 vs 60.3% (prior bortezomib) and 70.1 vs 59.3% (prior lenalidomide). The safety profile in the prior lines subgroups was qualitatively similar to that in the broader ENDEAVOR population. In RMM, outcomes are improved when receiving treatment with carfilzomib compared with bortezomib, regardless of the number of prior therapy lines or prior exposure to bortezomib or lenalidomide. © 2017 Macmillan Publishers Limited, part of Springer Nature.
Moreau P, Joshua D, Chng W-J, Palumbo A, Goldschmidt H, Hájek R, Facon T, Ludwig H, Pour L, Niesvizky R, et al. Impact of prior treatment on patients with relapsed multiple myeloma treated with carfilzomib and dexamethasone vs bortezomib and dexamethasone in the phase 3 ENDEAVOR study. Leukemia [Internet]. 2017;31(1):115 - 122. WebsiteAbstract
The randomized phase 3 ENDEAVOR study (N=929) compared carfilzomib and dexamethasone (Kd) with bortezomib and dexamethasone (Vd) in relapsed multiple myeloma (RMM). We performed a subgroup analysis from ENDEAVOR in patients categorized by number of prior lines of therapy or by prior treatment. Median progression-free survival (PFS) for patients with one prior line was 22.2 months for Kd vs 10.1 months for Vd, and median PFS for patients with ≥2 prior lines was 14.9 months for Kd vs 8.4 months for Vd. For patients with prior bortezomib exposure, the median PFS was 15.6 months for Kd vs 8.1 months for Vd, and for patients with prior lenalidomide exposure the median PFS was 12.9 months for Kd vs 7.3 months for Vd. Overall response rates (Kd vs Vd) were 81.9 vs 65.5% (one prior line), 72.0 vs 59.7% (≥2 prior lines), 71.2 vs 60.3% (prior bortezomib) and 70.1 vs 59.3% (prior lenalidomide). The safety profile in the prior lines subgroups was qualitatively similar to that in the broader ENDEAVOR population. In RMM, outcomes are improved when receiving treatment with carfilzomib compared with bortezomib, regardless of the number of prior therapy lines or prior exposure to bortezomib or lenalidomide. © 2017 Macmillan Publishers Limited, part of Springer Nature.
Gierens K, Eleftheratos K. Improvements to the HIRS channel 12 intercalibration for ice supersaturation studies. GSICS Quarterly Newsletter: Spring Issue 2017 [Internet]. 2017;11(1):6-7. Publisher's Version v11_no1_2017.pdf
Vlachou M, Siamidi A, Diamantidi E, Iliopoulou A, Papanastasiou I, Ioannidou V, Kourbeli V, Foscolos A-S, Vocat A, Cole ST, et al. In vitro Controlled Release from Solid Pharmaceutical Formulations of two new Adamantane Aminoethers with Antitubercular Activity (I). Drug Research [Internet]. 2017;67(8):447 - 450. Website
Vlachou M, Siamidi A, Spaneas D, Lentzos D, Ladia P, Anastasiou K, Papanastasiou I, Foscolos A-S, Georgiadis M-O, Karalis V, et al. In vitro Controlled Release of two new Tuberculocidal Adamantane Aminoethers from Solid Pharmaceutical Formulations (II). Drug Research [Internet]. 2017. Website
Vrachatis DA, Papaioannou TG, Vavuranakis M, Tousoulis D. In Vivo Assessment of Atherosclerotic Plaque Neovascularization by Contrast-Enhanced Ultrasound: An Unsolved Mystery?. J Am Soc Echocardiogr. 2017.
Gierens K, Eleftheratos K. On the intercalibration of HIRS channel 12 brightness temperatures following the transition from HIRS 2 to HIRS 3/4 for ice saturation studies. Atmospheric Measurement Techniques [Internet]. 2017;10:681-693. Publisher's Version a31_amt_2017.pdf
Pavlopoulos V, Motti-Stefanidi F. Intercultural Relations in Greece. In: Mutual Intercultural Relations. Cambridge, UK: Cambridge University Press; 2017. pp. 187-209. pdf
Mitsi E. "Killing the Humanist in Marlowe's The Massacre at Paris". War on the Human: New Responses to an Ever-Present Debate. 2017:174-190.
Karampela I, Kandri E, Antonakos G, Vogiatzakis E, Christodoulatos GS, Nikolaidou A, Dimopoulos G, Armaganidis A, Dalamaga M. Kinetics of circulating fetuin-A may predict mortality independently from adiponectin, high molecular weight adiponectin and prognostic factors in critically ill patients with sepsis: A prospective study. J Crit Care. 2017;41:78-85.Abstract
PURPOSE: Fetuin-A and adiponectin, major hepatokine and adipokine respectively, have been implicated in systematic inflammation. Our aim was to jointly investigate whether kinetics of circulating fetuin-A, adiponectin and its isoform HMWA predict 28-day mortality in sepsis. MATERIALS AND METHODS: In a prospective study, serum fetuin-A, adiponectin and HMWA were determined in 102 ICU patients fulfilling the diagnostic criteria of SEPSIS-3, at enrollment and one week after, and in 102 healthy controls matched on age and gender. RESULTS: Serum fetuin-A was significantly lower in septic patients than controls (p<0.001). Among septic patients, those with septic shock and nonsurvivors presented lower fetuin-A, but higher adiponectin and HMWA compared to patients with sepsis and survivors respectively, both at baseline and day 7 (p<0.001). Fetuin-A exhibited negative correlations with APACHE II, CRP, procalcitonin, adiponectin and IL-6 but a positive one with albumin. Reduced fetuin-A as well as lower serum kinetics of fetuin-A (HR: 0.55, 95% C.I. 0.34-0.91, p=0.02), adiponectin but not HMWA were independently associated with 28-day mortality adjusting for age, gender, BMI, APACHE II, septic shock and laboratory biomarkers. CONCLUSIONS: Circulating fetuin-A kinetics may be a prognostic biomarker in septic patients. More research is essential to elucidate fetuin-A's ontological role in sepsis pathophysiology.
Kritikou V. La imaginación-fuerza de sobrevivencia en Los ríos profundos de José María Arguedas. In: Estudios y Homenajes Hispanoamericanos V. Vol. 5. 1st ed. Madrid: Ediciones del Orto; 2017. pp. 139-149. kritikou.imaginacion.arguedas.pdf
Konstantinopoulos T, Petkov P, Goasduff A, Arici T, Astier A, Atanasova L, Axiotis M, Bonatsos D, Detistov P, Dewald A, et al. Lifetime measurements in $^{100}\mathrm{Ru}$. Phys. Rev. C. 2017;95:014309.
Panagiotidis P, Spyropoulos V, Revithiadou A. Little v as a categorizing verbal head: Evidence from Greek. In: The Verbal Domain. Oxford: Oxford University Press; 2017. pp. 29-48.Abstract
There is little morphological evidence for little v as a verbalizing head in the literature. Greek, however, exhibits systematic verbalizing morphology and provides us with a strong case study for a robust morphophonological manifestation of the verbalizing v head. Evidence comes from the second-conjugation verbs (e.g., aɣap-ó ‘I love’, ster-ó ‘I deprive’), which display certain distinct morphophonological properties: (a) they take a vocalic extension in certain forms (e.g., aɣáp-i-s-a ‘I loved’) and (b) they exhibit post-root stress, unlike other verb forms (e.g., miní-o ‘I sue’, pal-év-o ‘I fight’). Following Spyropoulos et al. (2015), we argue that both characteristics reflect the morphophonological effects of the exponence of a verbalizing head v by means of an empty vocalic element  V. Furthermore, we provide evidence that a set of verbalizers, almost exclusively identified with a number of derivational suffixes (e.g., -ev, -iz, -(i)az, -on, -ar and -en), are also exponents of this verbalizing v head which is distinct from Voice, is not correlated with agentivity, transitivity and inner aspect / Aktionsart, and, more importantly, do not follow the second conjugation pattern. We propose that the abstract vocalic slot and the verbal derivational suffixes compete for the same morphosyntactic position and that they are both exponents of the verbalizing head v. 
Sagonas K, Kapsalas G, Valakos E, Pafilis P. Living in sympatry: The effect of habitat partitioning on the thermoregulation of three Mediterranean lizards. J Therm Biol. 2017;65:130-137.Abstract
The ability for effective, accurate and precise thermoregulation is of paramount importance for ectotherms. Sympatric lizards often partition their niche and select different microhabitats. These microhabitats, however, usually differ in their thermal conditions and lizards have to adapt their thermoregulation behavior accordingly. Here, we evaluated the impact of habitat partitioning on the thermal biology of three syntopic, congeneric lacertids (Podarcis peloponnesiacus, P. tauricus and P. muralis) from central Peloponnese, Greece. We assessed thermoregulation effectiveness (E) using the three standard thermal parameters: body (Tb), operative (Te) and preferred (Tpref) temperatures. We hypothesized that the microhabitats used by each species would differ in thermal quality. We also predicted that all species would effectively thermoregulate, as they inhabit a thermally challenging mountain habitat. As expected, the partition of the habitat had an effect on the thermoregulation of lizards since microhabitats had different thermal qualities. All three species were effective and accurate thermoregulators but one of them achieved smaller E values as a result of the lower Tb in the field. This discrepancy could be attributed to the cooler (but more benign) thermal microhabitats that this species occupies.
Vassilakis E, Mallinis G, Christopoulou A, Farangitakis GP, Papanikolaou I, Arianoutsou M. Mapping Post-Fire Vegetaτion Recovery at Different Lithologies of Taygetos Mt (Greece) With Multi-Temporal Remote Sensing Data. In: EGU2017-7452. Vol. 19. Vienna, Austria; 2017. posterAbstract
Mt Taygetos (2407m), located at southern Peloponnese (Greece) suffered a large fire during the summer of 2007. The fire burned approximately 45% of the area covered by the endemic Greek fir (Abies cephalonica) and Black Pine (Pinus nigra) forest ecosystems. The aim of the current study is to examine the potential differences on post-fire vegetation recovery imposed by the lithology as well as the geomorphology of the given area over sites of the same climatic and landscape conditions (elevation, aspect, slope etc.). The main lithologies consist of carbonate, permeable, not easily erodible formations (limestones and marbles) and clastic, impermeable (schists, slate and flysch) erodible ones. A time-series of high spatial resolution satellite images were interpreted, analyzed and compared in order to detect changes in vegetation coverage which could prioritize areas of interest for fieldwork campaigns. The remote sensing datasets were acquired before (Ikonos-2), a few months after (Quickbird-2) and some years after (Worldview-3) the 2007 fire. High resolution Digital Elevation Model was used for the ortho-rectification and co-registration of the remote sensing data, but also for the extraction of the mountainous landscape characteristics. The multi-temporal image dataset was analyzed through GEographic-Object Based Image Analysis (GEOBIA). Objects corresponding to different vegetation types through time were identified through spectral and textural features. The classification results were combined with basic layers such as lithological outcrops, pre-fire vegetation, landscape morphology etc., supplementing a spatial geodatabase used for classifying burnt areas with varying post-fire plant community recovery. We validated the results of the classification during fieldwork and found that at a local scale, where the landscape features are quite similar, the bedrock type proves to be an important factor for vegetation recovery, as it clearly defines the soil generation along with its properties. Plant species recovery seems to be controlled by the local lithology as it was found weaker in plots overlying limestones and marbles, comparing to that observed over schists, even for the same species. In conclusion, post-fire vegetation recovery seems to be a complex process controlled not only from species biology, but also from the geological features.
Karakitsios V, Cornee JJ, Tsourou T, Moissette P, Kontakiotis G, Agiadi K, Manoutsoglou E, Triantaphyllou M, Koskeridou E, DRINIA H, et al. Messinian salinity crisis record under strong freshwater input in marginal, intermediate, and deep environments: The case of the North Aegean. Palaeogeography, Palaeoclimatology, Palaeoecology [Internet]. 2017;485:316-335. Publisher's Version
Mazis I. Methodology for Systemic Geopolitical Analysis according to the Lakatosian model. Global New Positioning: The Importance of Transatlantic Relations, Africa, Near East, Russia and Asia for Greece. 2017.Abstract
The absence of an epistemologically founded geopolitical analysis method that has been internationally observed was the motivation for writing the following contribution. The paper is divided into two parts: i) Definitions and Example analysis and ii) Determination of the Lakatosian Structure of the Systemic Geopolitical Analysis.
lxvi._methodology_for_systemic_geopolitical_analysis_according_to_the_lakatosian_model.pdf
Kontos CK, Tsiakanikas P, Avgeris M, Papadopoulos IN, Scorilas A. miR-15a-5p, A Novel Prognostic Biomarker, Predicting Recurrent Colorectal Adenocarcinoma. Molecular Diagnosis and Therapy. 2017:1-12.
Rapti S-M, Kontos CK, Christodoulou S, Papadopoulos IN, Scorilas A. miR-34a overexpression predicts poor prognostic outcome in colorectal adenocarcinoma, independently of clinicopathological factors with established prognostic value. Clinical Biochemistry [Internet]. 2017:-. WebsiteAbstract
AbstractObjectives MicroRNA-34a (miR-34a) is regulated by \{TP53\} and, in response, downregulates the expression of a gamut of protein-coding genes, including apoptosis regulators, transcription factors, cyclins, and cyclin-dependent kinases. Its upregulation initiates a reprogramming of gene expression and promotes apoptosis. The purpose of this study was the investigation of the potential clinical significance of miR-34a as a molecular prognostic biomarker in colorectal adenocarcinoma using an in-house real-time quantitative \{PCR\} (qPCR) methodology. Design and methods Total \{RNA\} was extracted from 113 primary colorectal adenocarcinoma specimens and 61 paired non-cancerous colorectal tissue samples. After polyadenylation and reverse transcription, miR-34a molecules were determined using qPCR based on \{SYBR\} Green chemistry. Calculations were performed using the comparative \{CT\} method. Finally, extensive biostatistical analysis was performed. Results miR-34a expression does not significantly differ between colorectal adenocarcinoma tissue specimens and adjacent non-cancerous mucosae. However, miR-34a increases progressively as colorectal adenocarcinoma loses its differentiation, being highest in grade İII\} tumors (P = 0.010). Moreover, miR-34a expression is a potential unfavorable prognostic biomarker in colorectal adenocarcinoma, predicting poor disease-free and overall survival (P = 0.002 and P = 0.019, respectively), independently of classical clinicopathological parameters. Most importantly, miR-34a expression stratifies patients without local (N0) and/or distant metastasis (M0) at the time of diagnosis into two groups with substantially different prognosis (P = 0.013 and P = 0.002, respectively). Conclusions High miR-34a levels in colorectal adenocarcinoma predict a rather increased risk for disease recurrence and poor overall survival, particularly in patients at an early \{TNM\} stage. The unfavorable prognostic potential of miR-34a expression is independent of established prognostic features of colorectal adenocarcinoma.
Moschonas IC, Kellici TF, Mavromoustakos T, Stathopoulos P, Tsikaris V, Magafa V, Tzakos AG, Tselepis AD. Molecular requirements involving the human platelet protease-activated receptor-4 mechanism of activation by peptide analogues of its tethered-ligand. Platelets [Internet]. 2017:1 - 10. Website
Kontakiotis G, Antonarakou A, Mortyn PG, DRINIA H, ANASTASAKIS G, Zarkogiannis S, Möbius  J. Morphological recognition of Globigerinoides ruber morphotypes and their susceptibility to diagenetic alteration in the eastern Mediterranean Sea. Journal of Marine Systems [Internet]. 2017;174:12-24. Publisher's Version
Kamberidou I. The Multiethnic Slavery Institution through the Eyes of Western Women and 'the real position of women in the religious system of Islam' (Second Edition). In: Media, Religion and Gender in Europe. Blanquerna Observatory on Media, Religion and Culture. Faculta de Comunicatio i Relacions Internacionals Blanquerna,Universitat Ramon Llull, Barcelona; 2017. pp. 53-79. 2nd_edition_media_religion_and_gender_in_europe_2017.pdf
Schulpis KH, Thodi G, Iakovou K, Chatzidaki M, Dotsikas Y, Molou E, Triantafylli O, Loukas YL. Mutational analysis of GALT gene in Greek patients with galactosaemia: identification of two novel mutations and clinical evaluation. Scandinavian Journal of Clinical and Laboratory Investigation [Internet]. 2017;77:423-427. Website
Mertzimekis TJ. A New Online Database of Nuclear Electromagnetic Moments. In: ND 2016 International Conference on Nuclear Data for Science and Technology. ; 2017.
Diakakis M, Nikolopoulos E, Mavroulis S, Vassilakis E, Korakaki E. Observational evidence on the effects of mega-fires on the frequency of hydrogeomorphic hazards. The case of the Peloponnese fires of 2007 in Greece. Science of The Total Environment [Internet]. 2017;592:262-276. pdfAbstract
Even though rare, mega-fires raging during very dry and windy conditions, record catastrophic impacts on infrastructure, the environment and human life, as well as extremely high suppression and rehabilitation costs. Apart from the direct consequences, mega-fires induce long-term effects in the geomorphological and hydrological processes, influencing environmental factors that in turn can affect the occurrence of other natural hazards, such as floods and mass movement phenomena. This work focuses on the forest fire of 2007 in Peloponnese, Greece that to date corresponds to the largest fire in the country's record that burnt 1773 km2, causing 78 fatalities and very significant damages in property and infrastructure. Specifically, this work examines the occurrence of flood and mass movement phenomena, before and after this mega-fire and analyses different influencing factors to investigate the degree to which the 2007 fire and/or other parameters have affected their frequency. Observational evidence based on several data sources collected during the period 1989–2016 show that the 2007 fire has contributed to an increase of average flood and mass movement events frequency by approximately 3.3 and 5.6 times respectively. Fire affected areas record a substantial increase in the occurrence of both phenomena, presenting a noticeably stronger increase compared to neighbouring areas that have not been affected. Examination of the monthly occurrence of events showed an increase even in months of the year were rainfall intensity presented decreasing trends. Although no major land use changes has been identified and chlorophyll is shown to recover 2 years after the fire incident, differences on the type of vegetation as tall forest has been substituted with lower vegetation are considered significant drivers for the observed increase in flood and mass movement frequency in the fire affected areas.
Karameta E, Mizan VL, Sagonas K, Sfenthourakis S, Valakos ED, Pafilis P. Ontogenetic shifts in the digestive efficiency of an insectivorous lizard (Squamata: Agamidae). Salamandra [Internet]. 2017;53(2):321 - 326. Website
Mitsopoulos I, Chrysafi I, Mallinis G, Vassilakis E, Arianoutsou M, Lekkas E.

Fire severity estimation using very high spatial resolution satellite imagery: the case of Chios island

. In: 17th Congress of Hellenic Forestry Society. Edessa, Greece; 2017.Abstract
The aim of this study is to spatially assess fire severity and to explore the relationship between the Normalized Vegetation Index (NDVI) derived from WorldView- 2 imagery and the field-based fire severity index “Composite Burn Index” (CBI) on a recent large fire that occurred on the island of Chios, Greece, in 2016. The statistical analysis indicated a relatively strong linear relationship between the NDVI and the CBI (R2 = 0.71). Predictive local thresholds of NDVI values have been determined for accurate thematic classification and mapping of fire severity classes. The overall classification accuracy based on NDVI from WorldView-2 was relatively high (71%), pointing to the potential of using such data for mapping forest fires in the Mediterranean as well as for assessing their severity. The application of the classification thresholds calculated in this study over other forest fire events on similar ecosystem types, could support the rapid assessment of fire severity and hence could enable the decisions needed for proper post-fire management.
Kenourgios D, Dimitriou D, Simos T.

Financial crises, exchange rate linkages and uncovered interest-rate parity: Evidence from G7 markets

. Economic Modelling [Internet]. 2017;66:112-120. Publisher's VersionAbstract
This paper examines the dynamic linkages among major exchange rates during the Global Financial Crisis and Eurozone Sovereign Debt Crisis. We extend the previous literature on volatility spillover linkages among the currencies by taking into account the uncovered interest-rate parity hypothesis for 2004–2015. The results indicate that the Canadian Dollar and Great British Pound were affected mainly by the US Dollar across the two crises due to strong financial and economic ties among the three economies, while the Japanese Yen shows evidence of a safe-haven currency. We also provide evidence of varying vulnerability of currencies to both crises, implying increased portfolio diversification benefits, since holding a portfolio with diverse currencies is less subject to systematic risk. These results show that the policy makers need to adopt a stricter form of monetary policy coordination among central banks, since the different vulnerability of currencies across turbulent periods reveals possible non-cooperative monetary policies.
Pafilis P, Maragou P, Sagonas K, Valakos E. Partitioning thermal habitat on a vertical rock, a herculean task. Journal of Thermal Biology [Internet]. 2017;70:54 - 60. WebsiteAbstract
Abstract Species occurring in sympatry have to effectively segregate their niche in order to co-exist. In the case of ectotherms in particular, the very important parameter of thermal biology has to be taken into account. Here we investigated the thermoregulatory effectiveness (E) of two endemic Greek lizards (Hellenolacerta graeca and Podarcis peloponnesiacus) that live syntopically on a rocky cliff in the Peloponnese. We presumed that the two species would select different microhabitats, to avoid interspecific competition, and follow a similar thermoregulation pattern as they experience the same conditions. We also expected that E values for both species would differ depending on the season. Overall, we found that the two species had similar E values for each season but differentiated partial thermoregulatory attributes. Though they both occurred in the same types of microhabitat, H. graeca selected higher sites (average 99cm above ground) than P. peloponnesiacus (average 44cm). Also, the latter achieved higher preferred temperatures during summer and winter. Finally, the effectiveness of thermoregulation for both species varied interseasonally and received its highest values during summer, in response to the lowest thermal quality that was observed then. Similar studies stress the importance of thermal shifts for ectotherm co-existence.
Pantazopoulos PA, Stefanou N, Almpanis E, Papanikolaou N. Photomagnonic nanocavities for strong light-spin wave interacton. Physical Review B. 2017;96(11):104425 (9 pages).Abstract
The interaction of visible and near-infrared light with spin waves in appropriately designed dual nanocavities, for both photons and magnons, is investigated by means of rigorous calculations, correct to arbitrary order in the magneto-optical coupling parameter. It is shown that the concurrent localization of the interacting photon and magnon fields in the same region of space for a long period of time enhances their mutual interaction, provided that specific selection rules are fulfilled. Our results provide evidence for the occurrence of strong effects, beyond the linear response approximation, which lead to enhanced modulation of light by spin waves through multimagnon absorption and emission processes by a photon.
Gongaki K. The Platonic myth of Gyges and the concept of justice and injustice in modern-day sport and the contempory world. Electryone [Internet]. 2017;5(2):1-10. Publisher's Version
Oikonomopoulou E-K, Valakos E, Nikita E. Population-specificity of sexual dimorphism in cranial and pelvic traits: evaluation of existing and proposal of new functions for sex assessment in a Greek assemblage. International Journal of Legal Medicine. 2017:1-8.
Peyron O, Combourieu-Nebout N, Brayshaw D, Goring S, Andrieu-Ponel V, Desprat S, Fletcher W, Gambin B, Ioakim C, Joannin S, et al. Precipitation changes in the Mediterranean basin during the Holocene from terrestrial and marine pollen records: a model–data comparison. Climate of the Past [Internet]. 2017;13:249-265. Publisher's VersionAbstract
Climate evolution of the Mediterranean region during the Holocene exhibits strong spatial and temporal variability, which is notoriously difficult for models to reproduce. We propose here a new proxy-based climate synthesis synthesis and its comparison – at a regional (∼ 100 km) level – with a regional climate model to examine (i) opposing northern and southern precipitation regimes and (ii) an east-to-west precipitation dipole during the Holocene across the Mediterranean basin. Using precipitation estimates inferred from marine and terrestrial pollen archives, we focus on the early to mid-Holocene (8000 to 6000 cal yr BP) and the late Holocene (4000 to 2000 cal yr BP), to test these hypotheses on a Mediterranean-wide scale. Special attention was given to the reconstruction of season-specific climate information, notably summer and winter precipitation. The reconstructed climatic trends corroborate the north–south partition of precipitation regimes during the Holocene. During the early Holocene, relatively wet conditions occurred in the south–central and eastern Mediterranean regions, while drier conditions prevailed from 45° N northwards. These patterns then reverse during the late Holocene. With regard to the existence of a west–east precipitation dipole during the Holocene, our results show that the strength of this dipole is strongly linked to the reconstructed seasonal parameter; early-Holocene summers show a clear east–west division, with summer precipitation having been highest in Greece and the eastern Mediterranean and lowest over Italy and the western Mediterranean. Summer precipitation in the east remained above modern values, even during the late-Holocene interval. In contrast, winter precipitation signals are less spatially coherent during the early Holocene but low precipitation is evidenced during the late Holocene. A general drying trend occurred from the early to late Holocene, particularly in the central and eastern Mediterranean.For the same time intervals, pollen-inferred precipitation estimates were compared with model outputs, based on a regional-scale downscaling (HadRM3) of a set of global climate-model simulations (HadAM3). The high-resolution detail achieved through the downscaling is intended to enable a better comparison between site-based paleo-reconstructions and gridded model data in the complex terrain of the Mediterranean; the model outputs and pollen-inferred precipitation estimates show some overall correspondence, though modeled changes are small and at the absolute margins of statistical significance. There are suggestions that the eastern Mediterranean experienced wetter summer conditions than present during the early and late Holocene; the drying trend in winter from the early to the late Holocene also appears to be simulated. The use of this high-resolution regional climate model highlights how the inherently patchy nature of climate signals and paleo-records in the Mediterranean basin may lead to local signals that are much stronger than the large-scale pattern would suggest. Nevertheless, the east-to-west division in summer precipitation seems more marked in the pollen reconstruction than in the model outputs. The footprint of the anomalies (like today, or dry winters and wet summers) has some similarities to modern analogue atmospheric circulation patterns associated with a strong westerly circulation in winter (positive Arctic Oscillation–North Atlantic Oscillation (AO–NAO)) and a weak westerly circulation in summer associated with anticyclonic blocking; however, there also remain important differences between the paleo-simulations and these analogues. The regional climate model, consistent with other global models, does not suggest an extension of the African summer monsoon into the Mediterranean. Therefore, the extent to which summer monsoonal precipitation may have existed in the southern and eastern Mediterranean during the mid-Holocene remains an outstanding question.
Poeschl G, Valentim J, Papastamou S, Chryssochoou X, Prodromitis G, Pavlopoulos V, Mari S, Volpato C. Predictors of the perceived efficacy of actions against austerity measures. International Review of Social Psychology [Internet]. 2017;30(1). doi
Papadavid E, Dalamaga M, Vlami K, Koumaki D, Gyftopoulos S, Christodoulatos GS, Papiris S, Rigopoulos D. Psoriasis is associated with risk of obstructive sleep apnea independently from metabolic parameters and other comorbidities: a large hospital-based case-control study. Sleep Breath. 2017.Abstract
PURPOSE: Obstructive sleep apnea (OSA) represents a breathing disorder during sleep with significant health consequences. Few studies have examined the prevalence of OSA in psoriatic patients and whether OSA may be associated with psoriasis risk. We aimed to explore: (1) the inverse relationship, that is whether psoriasis might represent an independent predictor of OSA and its severity considering important predisposing factors and (2) the psoriatic phenotype related to severe OSA. METHODS: In a large hospital-based case-control study, we examined a total of 253 patients with OSA and a control group of 104 subjects without OSA, who underwent full nocturnal polysomnography and dermatologic examination. RESULTS: The prevalence of psoriasis was significantly greater in OSA patients than in controls (p = 0.03). Psoriasis was associated with OSA risk (p = 0.04) but not severity of OSA, sleepiness severity or sleep efficiency, independently from age, gender, anthropometric features, and significant comorbidities. The phenotype of a psoriatic patient suffering from severe OSA is not different from that of a patient with severe OSA and is not associated with psoriasis severity indexes. OSA psoriatic patients were not compliant with CPAP treatment in comparison with OSA patients without psoriasis. CONCLUSION: Psoriasis may represent an independent risk factor for OSA above and beyond significant comorbidities, anthropometric and metabolic parameters. Physicians should be aware of the bi-directional association of psoriasis and OSA. Managing psoriasis may be a potential target for preventing OSA as well as the potential cardiovascular mortality related to OSA and psoriasis.
Vrontaki E, Mavromoustakos T, Melagraki G, Afantitis A. Quantitative nanostructure-activity relationship models for the risk assessment of nanomaterials. In: Materials Science and Engineering: Concepts, Methodologies, Tools, and Applications. Vol. 1-3. ; 2017. pp. 20 - 44. Website
Hájek R, Masszi T, Petrucci MT, Palumbo A, Rosiñol L, Nagler A, Yong KL, Oriol A, Minarik J, Pour L, et al. A randomized phase III study of carfilzomib vs low-dose corticosteroids with optional cyclophosphamide in relapsed and refractory multiple myeloma (FOCUS). Leukemia [Internet]. 2017;31(1):107 - 114. WebsiteAbstract
This randomized, phase III, open-label, multicenter study compared carfilzomib monotherapy against low-dose corticosteroids and optional cyclophosphamide in relapsed and refractory multiple myeloma (RRMM). Relapsed and refractory multiple myeloma patients were randomized (1:1) to receive carfilzomib (10-min intravenous infusion; 20 mg/m 2 on days 1 and 2 of cycle 1; 27 mg/m 2 thereafter) or a control regimen of low-dose corticosteroids (84 mg of dexamethasone or equivalent corticosteroid) with optional cyclophosphamide (1400 mg) for 28-day cycles. The primary endpoint was overall survival (OS). Three-hundred and fifteen patients were randomized to carfilzomib (n=157) or control (n=158). Both groups had a median of five prior regimens. In the control group, 95% of patients received cyclophosphamide. Median OS was 10.2 (95% confidence interval (CI) 8.4-14.4) vs 10.0 months (95% CI 7.7-12.0) with carfilzomib vs control (hazard ratio=0.975; 95% CI 0.760-1.249; P=0.4172). Progression-free survival was similar between groups; overall response rate was higher with carfilzomib (19.1 vs 11.4%). The most common grade ≥3 adverse events were anemia (25.5 vs 30.7%), thrombocytopenia (24.2 vs 22.2%) and neutropenia (7.6 vs 12.4%) with carfilzomib vs control. Median OS for single-agent carfilzomib was similar to that for an active doublet control regimen in heavily pretreated RRMM patients. © 2017 Macmillan Publishers Limited, part of Springer Nature.
Hájek R, Masszi T, Petrucci MT, Palumbo A, Rosiñol L, Nagler A, Yong KL, Oriol A, Minarik J, Pour L, et al. A randomized phase III study of carfilzomib vs low-dose corticosteroids with optional cyclophosphamide in relapsed and refractory multiple myeloma (FOCUS). Leukemia [Internet]. 2017;31(1):107 - 114. WebsiteAbstract
This randomized, phase III, open-label, multicenter study compared carfilzomib monotherapy against low-dose corticosteroids and optional cyclophosphamide in relapsed and refractory multiple myeloma (RRMM). Relapsed and refractory multiple myeloma patients were randomized (1:1) to receive carfilzomib (10-min intravenous infusion; 20 mg/m 2 on days 1 and 2 of cycle 1; 27 mg/m 2 thereafter) or a control regimen of low-dose corticosteroids (84 mg of dexamethasone or equivalent corticosteroid) with optional cyclophosphamide (1400 mg) for 28-day cycles. The primary endpoint was overall survival (OS). Three-hundred and fifteen patients were randomized to carfilzomib (n=157) or control (n=158). Both groups had a median of five prior regimens. In the control group, 95% of patients received cyclophosphamide. Median OS was 10.2 (95% confidence interval (CI) 8.4-14.4) vs 10.0 months (95% CI 7.7-12.0) with carfilzomib vs control (hazard ratio=0.975; 95% CI 0.760-1.249; P=0.4172). Progression-free survival was similar between groups; overall response rate was higher with carfilzomib (19.1 vs 11.4%). The most common grade ≥3 adverse events were anemia (25.5 vs 30.7%), thrombocytopenia (24.2 vs 22.2%) and neutropenia (7.6 vs 12.4%) with carfilzomib vs control. Median OS for single-agent carfilzomib was similar to that for an active doublet control regimen in heavily pretreated RRMM patients. © 2017 Macmillan Publishers Limited, part of Springer Nature.
Schulpis KH, Thodi G, Chatzidaki M, Iakovou K, Molou E, Dotsikas Y, Loukas YL. Rare cases of galactose metabolic disorders: Identification of more than two mutations per patient. Journal of Pediatric Endocrinology and Metabolism [Internet]. 2017;30:1119-1120. Website
Kellici TF, Chatziathanasiadou MV, Lee M-S, Sayyad N, Geromichalou EG, Vrettos EI, Tsiailanis AD, Chi S-W, Geromichalos GD, Mavromoustakos T, et al. Rational design and structure-activity relationship studies of quercetin-amino acid hybrids targeting the anti-apoptotic protein Bcl-xL. Organic and Biomolecular Chemistry [Internet]. 2017;15(37):7956 - 7976. Website
Mazis I. The rationale of NATO founding and N.J. Spykman’s geopolitical example. Regional Science Inquiry. 2017;IX(1).Abstract
The foundation of NATO on April 4th, 1949 marked in the most exquisite manner the disintegration of the alliance of the US, Great Britain and USSR which lasted during WWII. At the same time it coincided with the introduction of a new post-war system of power equilibrium, with the Cold War as its main characteristic. This total geopolitical confrontation of the two superpowers and their respective satellites extended around the globe, begun in the ruins of post-war Europe, where the long-standing geopolitical ambitions of both sides manifested themselves, reinforced through the reproduction of established myths and stereotypes, as well as national interests. This power equilibrium was based on the framework of values and principles put forth by the UN Charter in 1945 as the bedrock of the postwar international system. The guiding principles of the UN Charter prescribe the delegitimization of the use of violence in international relations as an accepted way of solving international disputes (Articles 2.3 and 2.4), respect of the domestic jurisdiction of any state (Article 2.7), and the right of self-defense, even in its version of collective self defense, as defined in Article 51 (and thereafter in the corresponding Article 5 of the NATO Charter and the corresponding provisions of the Warsaw Pact). The new post-war world order was built amidst an atmosphere of insecurity, fear, distrust and even hate, emanating from both sides. As a consequence Germany was divided between two states, while the whole of Europe was divided between two blocs. The so-called West and the USSR came to a confrontation through the blockade of Berlin by the Soviets (1948-1949). It was during that period that ΝΑΤΟ was created.
lxv._the_rationale_of_nato_founding_and_n.j._spykmans_geopolitical_example.pdf rsi_june_2017_ix_1.pdf
Papaioannou TG, Karageorgopoulou TD, Sergentanis TN, Protogerou AD, Psaltopoulou T, Sharman JE, Weber T, Blacher J, Daskalopoulou SS, Wassertheurer S, et al. Reply. J Hypertens. 2017;35:894-896.
Aissopou EK, Protogerou AD, Papaioannou TG, Tektonidou M, Tentolouris N, Theodossiadis PG, Stehouwer CDA, Kitas GD, Sfikakis PP. Retinal vascular calibers in contemporary patients with chronic systemic inflammatory diseases: The Greek REtinal Microcirculation (GREM) study. Artery Research [Internet]. 2017;18:1 - 6. Website
Vrontaki E, Melagraki G, Afantitis A, Mavromoustakos T, Kollias G. Searching for novel janus kinase-2 inhibitors using a combination of pharmacophore modeling, 3D-QSAR studies and virtual screening. Mini-Reviews in Medicinal Chemistry [Internet]. 2017;17(3):268 - 294. Website
Pafilis P, Sagonas K, Kapsalas G, Foufopoulos J, Valakos ED. Sex does not affect tail autotomy in lacertid lizards. Acta Herpetologica. 2017;12(1):19-27.
Toumazatou A, Arfanis MK, Pantazopoulos PA, Kontos AG, Falaras P, Stefanou N, Likodimos V. Slow-photon enhancement of dye sensitized TiO2 photocatalysis. Materials Letters. 2017;197:123-126.Abstract
Photonic band gap engineered TiO2 inverse opals were fabricated using self- assembled polystyrene films as sacrificial templates with controlled optical properties, aimed at the identification of the slow-photon effect on dye sensitized TiO2 photocatalysis. The materials’ photocatalytic efficiency was evaluated using Raman spectroscopy, on methylene blue photodegradation following both UVA and monochromatic visible light illumination. Contrary to UVA, where no photonic effect could be traced, laser irradiation within the slow-photon energy range of the TiO2 inverse opals, resulted in a marked increase of the dye photosensitized degradation rate, outperforming not only compact nanocrystalline films but also the benchmark mesoporous Aeroxide® P25 TiO2 films. This effect provides direct evidence for the presence of slow photons that amplify the interaction of visible light with the adsorbed dye molecules on the periodically structured TiO2 film.
Giannopoulos N, Vagenas G, Noutsos K, Barzouka K, Bergeles N. Somatotype, Level of Competition, and Performance in Attack in Elite Male Volleyball. Journal of Human Kinetics [Internet]. 2017;58:131-140. Publisher's VersionAbstract
This study investigated the relationship between somatotype, level of competition, and performance in attack in elite level male volleyball players. The objective was to test for the potential covariation of competition level (Division A1 vs. A2) and playing position (hitters vs. centers vs. opposites) considering performance in attack. Anthropometric, body composition and somatotype variables were measured according to the Heath-Carter method. The attack actions of 144 players from 48 volleyball matches were analyzed and their performance was rated using a 5-point numerical scale. Results showed that players of Division A1 were taller, heavier, more muscular, and less endomorphic compared to those of Division A2. MANOVA and follow-up discriminant function analysis revealed somatotype differences among playing positions with centers and opposites being endomorph-ectomorph and hitters being central. Centers performed constantly better than hitters and opposites regardless of division and somatotype. Multiple linear regression analysis showed that variables defining ectomorph and endomorph players, centers, and players of Division A1 significantly determined the relative performance superiority and were able to explain the variation in performance by almost 25%. These results could be taken into account by coaches when assigning players to particular playing positions or when designing individualized position-specific training programs.
<span style="font-family: Arial; font-size: small;"><em>Inlerlingual Perspectives<br />Διαγλωσσικές Θεωρήσεις<br /></em></span>
Inlerlingual Perspectives
Διαγλωσσικές Θεωρήσεις
. 1st ed. (Sidiropoulou M). Athens: National and Kapodistrian University of Athens/The Meta-fraseis Translation Programme; 2017 pp. 1-509. Publisher's VersionAbstract
Inlerlingual Perspectives (http://en.metafraseis.enl.uoa.gr/interlingual-perspectives-e-volume/contents-of-the-e-volume.html)/Διαγλωσσικές Θεωρήσεις (http://metafraseis.enl.uoa.gr/metafraseologikos-h-tomos-diaglwssikes-8ewrhseis/periexomena-toy-h-tomoy.html) is a bilingual e-volume comprising occasional research articles (2010- ) focusing on the interaction of Greek with other languages through translation. Ιt invites contributions from various theoretical perspectives in translation studies (and beyond) which may shed light to the study of phenomena that are treated diffrerently cross-culturally.  The volume invites original research papers which highlight socio-cultural features of Greek in juxtaposition to other languages, as traced through translation of any type of genre: political, literary, theatrical, scientific, commercial, technical etc.   It foregrounds the potential of translators to register, in discourse, perspectives which realize dominant (or peripheral) ideological positions or narratives reverberating in a target society, whether public narratives or personal socio-political positions. The e-volume welcomes perspectives drawing on various theoretical approaches in translation studies, which may shed light on aspects of the difference of Greek vs. other languages (not necessarily the hegemonic ones). The e-volume hopes to broaden perception of interlingual variation as it is manifested through translation or interpreting. Highlighting difference in a translation context foregrounds aspects of the character of Greek vs. those of other languages, contriburing to identity awareness, aspects of translators' roles highlighting their potential to affect target culture (and the responsibility this potential assumes), while it develops competencies (professional and/or linguitic) in both languages.
slide2.jpg
Arianoutsou Μ, Mitsopoulos Ι, Vallatou Μ, Vassilakis Ε, Mallinis G. A spatial modeling approach to assess fire risk and exposure of biodiversity hotspots in Cephalonia island, Greece. In: XIV MEDECOS & XIII AEET meeting. Seville, Spain; 2017. pp. 16.Abstract
Recent global changes seem to have affected fire regimes by inducing more severe larger fires in the thermomediterranean vegetation zone but also more frequent incidents in territories of higher altitudes. Cephalonia island hosts Mt Ainos, one of the most important National Parks of Greece, focal geographical area of the non-fire adapted endemic fir Abies cephalonica. The island has suffered several fires in the past. The aim of this work is to introduce a framework for assessing spatial fire risk and exposure of biodiversity hot spot areas, using Cephalonia as a pilot case study. Fuel parameters in representative vegetation types were measured across the island for models development as well as for collecting training and validation points for satellite data classification. The Minimum Travel Time algorithm, as it is embedded in FlamMap spatial fire simulation software, was applied in order to assess critical fire behavior parameters and exposure of the island’s biodiversity hotspots under three different meteorological and fuel moisture scenarios simulating predicted climate changes. In addition, the risk of change in the island's ecological value due to biodiversity loss was studied under the same scenarios. According to the analysis, loss of all biodiversity values was found under the severe meteorological and fuel moisture scenario and was estimated to be higher in the endemic fir forests. The outputs of this study may be used as an application of quantitative and probabilistic risk assessment for biodiversity conservation planning, prioritization and management of high value natural and cultural resources.
Vagenas G. Statistical Applications in Sport Science With Examples in SPSS (in Greek). 5th ed. Athens (ISBN: 960-90200-2-x): Vagenas G; 2017 pp. 464.
Burnetas A, Economou A, Vasiliadis G. Strategic customer behavior in a queueing system with delayed observations. Queueing Systems [Internet]. 2017:1-30. WebsiteAbstract
We consider the single-server Markovian queue with infinite waiting space and assume that there exists a certain reward-cost structure that reflects the customers’ desire for service and their dislike for waiting. The system is unobservable for the customers at their arrival instants, but the administrator provides them with periodic announcements of their current positions at rate (Formula presented.), so that they may renege if it is preferable for them to do so. The customers are strategic, and their decision problem is whether to join or not the system upon arrival and whether to stay or renege later. Their strategies are specified by a join probability q and a reneging threshold n. We determine the equilibrium strategies (Formula presented.) and study the socially optimal strategies (Formula presented.). Extensive numerical experiments provide interesting qualitative insight about the model. In particular, the equilibrium throughput of the system is a unimodal function of (Formula presented.). Moreover, despite the fact that we have an avoid-the-crowd situation, it is possible that (Formula presented.), in contrast to the classical unobservable model. © 2017 Springer Science+Business Media New York
Norström E, Katrantsiotis C, Smittenberg RH, Kouli K. Chemotaxonomy in some Mediterranean plants and implications for fossil biomarker records. Geochimica et Cosmochimica Acta [Internet]. 2017;219:96-110. Publisher's VersionAbstract
The increasing utilization of n-alkanes as plant-derived paleo-environmental proxies calls for improved chemotaxonomic control of the modern flora in order to calibrate fossil sediment records to modern analogues. Several recent studies have investigated long-chain n-alkane concentrations and chain-length distributions in species from various vegetation biomes, but up to date, the Mediterranean flora is relatively unexplored in this respect. Here, we analyse the n-alkane concentrations and chain-length distributions in some of the most common species of the modern macchia and phrygana vegetation in south western Peloponnese, Greece. We show that the drought adapted phrygana herbs and shrubs, as well as some of the sclerophyll and gymnosperm macchia components, produce high concentrations of n-alkanes, on average more than double n-alkane production in local wetland reed vegetation. Furthermore, the chain-length distribution in the analysed plants is related to plant functionality, with longer chain lengths associated with higher drought adaptive capacities, probably as a response to long-term evolutionary processes in a moisture limited environment. Furthermore, species with relatively higher average chain lengths (ACL) showed more enriched carbon isotope composition in their tissues (δ13Cplant), suggesting a dual imprint from both physiological and biochemical drought adaptation. The findings have bearings on interpretation of fossil sedimentary biomarker records in the Mediterranean region, which is discussed in relation to a case study from Agios Floros fen, Messenian plain, Peloponnese. The 6000 year long n-alkane record from Agios Floros (ACL, δ13Cwax) is linked to the modern analogue and then evaluated through a comparison with other regional-wide as well as local climate and vegetation proxy-data. The high concentration of long chain n-alkanes in phrygana vegetation suggests a dominating imprint from this vegetation type in sedimentary archives from this ecotone.
Bathrellos GD, Skilodimou HD, Maroukian H, Gaki-Papanastasiou K, Kouli K. Pleistocene glacial and lacustrine activity in the southern part of Mount Olympus (central Greece. Area [Internet]. 2017;49(2):137-147. Publisher's Version
Hatzaki M, Bitsa E, Flocas HA, Kouroutzoglou J, Garde L, Simmonds I. Study of cold anticyclones generating in the Mediterranean. In: Karacostas T, Bais A, Nastos PT Perspectives on Atmospheric Sciences. 1st ed. Springer International Publishing; 2017. pp. 515–520.
Koukoula M, Dotsikas Y, Molou E, Schulpis KH, Thodi G, Chatzidaki M, Triantafylli O, Loukas YL. Study of the effect of CYP2C19 polymorphisms on omeprazole pharmacokinetics by utilizing validated LC–MS/MS and Real Time-PCR methods. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences [Internet]. 2017;1047:173-179. Website
Papadaki GF, Amillis S, Diallinas G. Substrate Specificity of the FurE Transporter Is Determined by Cytoplasmic Terminal Domain Interactions. Genetics. 2017.Abstract
FurE, a member of the NCS1 transporter family in Aspergillus nidulans, is specific for allantoin, uric acid, uracil and related analogues. Herein, we show that C- or N-terminally truncated FurE transporters (FurE-ΔC or FurE-ΔΝ) present increased protein stability, but also inability for uric acid transport. To better understand the role of cytoplasmic terminal regions, we characterized genetic suppressors that restore FurE-ΔC-mediated uric acid transport. Suppressors map in the periphery of the substrate-binding site (Thr133 in TMS3 and Val343 in TMS8), an outward-facing gate (Ser296 in TMS7, Ile371 in TMS9, Tyr392 and Leu394 in TMS10) or in flexible loops (Asp26 in LN, Gly222 in L5, Asn308 in L7). Selected suppressors were shown to also restore the wild-type specificity of FurE-ΔΝ, suggesting that both C- and/or N-terminal domains are involved in intramolecular dynamics critical for substrate selection. A direct, substrate-sensitive, interaction of C- and/or N-terminal domains was supported by bimolecular fluorescence complementation assays. To our knowledge, this is the first case where not only the function, but also, the specificity of a eukaryotic transporter is regulated by its terminal cytoplasmic regions.
Weisel K, Doyen C, Dimopoulos M, Yee A, Lahuerta JJ, Martin A, Travers K, Druyts E, Toor K, Abildgaard N, et al. A systematic literature review and network meta-analysis of treatments for patients with untreated multiple myeloma not eligible for stem cell transplantation. Leukemia and Lymphoma [Internet]. 2017;58(1):153 - 161. WebsiteAbstract
In newly diagnosed multiple myeloma (MM), patients ineligible for front-line autologous stem cell transplantation (ASCT), melphalan and prednisone (MP) with thalidomide (MPT) or bortezomib (VMP) are standard first-line therapeutic options. Despite new treatment regimens incorporating bortezomib or lenalidomide, MM remains incurable. The FIRST study demonstrated significant improvement in progression-free survival (PFS) and overall survival (OS) for the combination of lenalidomide and low-dose dexamethasone (Rd) until progression vs. MPT in transplant-ineligible ndMM patients. However, to date no head-to-head randomized controlled trials (RCTs) have compared Rd or MPT versus VMP. We conducted a network meta-analysis using RCTs identified through a systematic literature review to evaluate the relative efficacy of Rd versus other regimens on survival endpoints in previously untreated MM patients ineligible for ASCT. In this analysis, Rd was associated with a significant PFS and survival advantage versus other first-line treatments (VMP, MPT, MP), challenging the role of alkylators in this setting. © 2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
Weisel K, Doyen C, Dimopoulos M, Yee A, Lahuerta JJ, Martin A, Travers K, Druyts E, Toor K, Abildgaard N, et al. A systematic literature review and network meta-analysis of treatments for patients with untreated multiple myeloma not eligible for stem cell transplantation. Leukemia and Lymphoma [Internet]. 2017;58(1):153 - 161. WebsiteAbstract
In newly diagnosed multiple myeloma (MM), patients ineligible for front-line autologous stem cell transplantation (ASCT), melphalan and prednisone (MP) with thalidomide (MPT) or bortezomib (VMP) are standard first-line therapeutic options. Despite new treatment regimens incorporating bortezomib or lenalidomide, MM remains incurable. The FIRST study demonstrated significant improvement in progression-free survival (PFS) and overall survival (OS) for the combination of lenalidomide and low-dose dexamethasone (Rd) until progression vs. MPT in transplant-ineligible ndMM patients. However, to date no head-to-head randomized controlled trials (RCTs) have compared Rd or MPT versus VMP. We conducted a network meta-analysis using RCTs identified through a systematic literature review to evaluate the relative efficacy of Rd versus other regimens on survival endpoints in previously untreated MM patients ineligible for ASCT. In this analysis, Rd was associated with a significant PFS and survival advantage versus other first-line treatments (VMP, MPT, MP), challenging the role of alkylators in this setting. © 2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
Sagonas K, Karambotsi N, Bletsa A, Reppa A, Pafilis P, Valakos ED. Tail regeneration affects the digestive performance of a Mediterranean lizard. Naturwissenschaften. 2017;104(3-4):22.Abstract
In caudal autotomy, lizards shed their tail to escape from an attacking predator. Since the tail serves multiple functions, caudal regeneration is of pivotal importance. However, it is a demanding procedure that requires substantial energy and nutrients. Therefore, lizards have to increase energy income to fuel the extraordinary requirements of the regenerating tail. We presumed that autotomized lizards would adjust their digestion to acquire this additional energy. To clarify the effects of tail regeneration on digestion, we compared the digestive performance before autotomy, during regeneration, and after its completion. Tail regeneration indeed increased gut passage time but did not affect digestive performance in a uniform pattern: though protein income was maximized, lipid and sugar acquisition remained stable. This divergence in proteins may be attributed to their particular role in tail reconstruction, as they are the main building blocks for tissue formation.
Despotopoulou A. "Terrible Traps to Memory": National Monuments, Collective Memory, and Women in Henry James. Modern Fiction Studies. 2017;63(3):429-451.
Kamberidou I, Karteroliotis K, Venetsanou F, Dania A. THINKING GLOBALLY AND ACTING LOCALLY: THE POWER OF PLAY AND GAMES. Creating a tech tool to promote European Traditional Sports and Games from an intergenerational and inclusive perspective, ERASMUS PLUS Small Collaborative Partnership-GEO-LUDENS:Discussion-proposals for 1st meeting in Zaragoza Spain, 9-10/2/ 2017. 2017;(GEO-LUDENS partnership, Zaragoza Spain,).Abstract
Creating a tech tool to promote European Traditional Sports and Games from an intergenerational and inclusive perspective, ERASMUS PLUS Small Collaborative Partnership-GEO-LUDENS:  ©Discussion-proposals-Greek team’s contribution for upcoming meetings in Zaragoza Spain, Feb. 9-10, 2017***Also attached: Kick-off MEETING AGENDA, 9-10 February, 2017.  Universidad San Jorge. Campus Villanueva de Gállego (Zaragoza), Spain
thinking_globally_and_acting_locally.pdf geo_ludens_kickoffmeeting_agenda_2017.pdf
Kountouris P, Angelonidis I, Drikos S. Time characteristics of four consecutive Olympic Volleyball Games after the implementation of the new regulations. Journal of Physical Activity, Nutrition and Rehabilitation [Internet]. 2017:190-198. Publisher's VersionAbstract
The purpose of the present study was to investigate the time characteristics four consecutive Olympic Games after the implementation of the new regulations, both in men and women. Data concerns the points and the duration of the set and the match as well and the total match duration, from Olympic volleyball games (Sidney 2000, Athens 2004, Beijing 2008 and London 2012). In total 312 matches were analyzed. Results indicated a continuous significant increase in the set and accordingly match duration's, both in men and women. Overall the mean set duration for each of the first four sets increased from around 22 minutes in Sydney to 26 minutes in London and the fifth sets increased from around 15 minutes to 17.5 minutes respectively. This may be is a consequence of the teams’ primary commitment to performance improvement in the defense tactics and the special attention given to the avoidance of faults. In conclusion, the implementation of the new rules since 2000, especially those related with the change to the rally point system, with each set played to 25 points and the introduction of rule for libero player have forced volleyball coaches and players to reevaluate their strategies and tactics in the goal of winning a rally, a set and a game. The collateral prolongation of the rallies and the increased uncertainty of the outcome have undeniably made the game more spectacular and intriguing to watch.Keywords: Volleyball; Time characteristics; Rules.
panrar_16015.pdf
Papaioannou TG, Protogerou AD, Argyris A, Aissopou E, Georgiopoulos G, Nasothimiou E, Tountas C, Sfikakis PP, Stergiopulos N, Tousoulis D. Total arterial compliance, estimated by a novel method, is better related to left ventricular mass compared to aortic pulse wave velocity: The SAFAR study. Clin Exp Hypertens. 2017;39(3):271-276.Abstract
AIM: The investigation of the association between total arterial compliance (CT)-estimated by a novel technique-with left ventricular mass (LVM) and hypertrophy (LVH). Our hypothesis was that CT may be better related to LVM compared to the gold-standard regional aortic stiffness. Within the frame of the ongoing cross-sectional study "SAFAR," 226 subjects with established hypertension or with suspected hypertension underwent blood pressure (BP) assessment, carotid-to-femoral pulse wave velocity (cf-PWV), and echocardiographic measurement of LVM. LVM index (LVMI) was calculated by the ratio of LVM to body surface area. CT was estimated by a previously proposed and validated formula: CT = 36.7 /cf-PWV2 [ml/mmHg]. LVMI was related to age (r = 0.207, p = 0.002), systolic BP (r = 0.248, p < 0.001), diastolic BP (r = 0.139, p = 0.04), mean BP (r = 0.212, p = 0.002), pulse pressure (r = 0.212, p = 0.002), heart rate (r = -0.172, p = 0.011), cf-PWV (r = 0.268, p < 0.001), and CT (r = -0.317, p < 0.001). The highest correlation was observed for CT that was significantly stronger than the respective correlation of cf-PWV (p < 0.001). In multivariate analysis, CT was a stronger determinant, compared to cf-PWV, of LVMI and LVH. It remains to be further explored whether CT has also a superior prognostic value beyond and above local or regional (segmental) estimates of pulse wave velocity.
Macek J, Macková A, Pavlopoulos V, Kalmus V, Elavsky MC, Šerek J. Trust in alternative and professional media: The case of the youth news audiences in three European countries. European Journal of Developmental Psychology [Internet]. 2017:1-15. doi
ATHANASSOPOULOU EKAVI. Turkey's Approach Towards Israel in the 1950s: Not Merely Following US policy. Middle Eastern Studies [Internet]. 2017;53(6):899-914. Publisher's VersionAbstract
Within the context of Turkey's relationship with Israel, the 1950s are remembered largely as the decade when bilateral relations developed dramatically reflecting the US orientation of Adnan Menderes's foreign policy. On closer observation, however, one cannot fail to notice that there was more ebb than flow in Turkey's policy towards Israel which already assumed the double-faced profile (cold or reproachful in public/positive behind closed doors), which is usually associated with the next two decades. Drawing on substantial research in official US and British archives, this article explores the multiple considerations which informed the approach of the Menderes government towards Tel-Aviv. Crucially, it places the Turks’ approach within their broader Middle Eastern policy with the aim of showing that it was shaped not only by their relationship with their powerful ally, the United States, but also by the need to look after relations with neighbourly Arab regimes.
Vrettos EI, Sayyad N, Mavrogiannaki EM, Stylos E, Kostagianni AD, Papas S, Mavromoustakos T, Theodorou V, Tzakos AG. Unveiling and tackling guanidinium peptide coupling reagent side reactions towards the development of peptide-drug conjugates. RSC Advances [Internet]. 2017;7(80):50519 - 50526. Website
Diamantopoulos MA, Kontos CK, Kerimis D, Papadopoulos IN, Scorilas A. Upregulated miR-16 expression is an independent indicator of relapse and poor overall survival of colorectal adenocarcinoma patients. Clinical Chemistry and Laboratory Medicine [Internet]. 2017;55:737-747. Website
Diamantopoulos MA, Kontos CK, Kerimis D, Papadopoulos IN, Scorilas A. Upregulated miR-16 expression is an independent indicator of relapse and poor overall survival of colorectal adenocarcinoma patients. Clinical Chemistry and Laboratory Medicine. 2017;55:737-747.
Kellici TF, Ntountaniotis D, Vanioti M, Golic Grdadolnik S, Simcic M, Michas G, Moutevelis-Minakakis P, Mavromoustakos T. The use of J-coupling as a sole criterion to assign the total absolute stereochemistry of new pyrrolidinone class synthetic analogs, derived from S-pyroglutamic acid. Journal of Molecular Structure [Internet]. 2017;1129:195 - 199. Website
Patsantaras N, Kamberidou I. Virtual Bodies and Sport Activities: The case of the Avatars in Second Life Fitness Club. 13th Conference of the European Sociological Association “Un)Making Europe: Capitalism, Solidarities, Subjectivities” [Internet]. 2017;(European Sociological Association). Publisher's VersionAbstract
RN24_09a_P: Science, Technology, Innovation & Society II (Time: 01/Sep/2017: 11:00am-12:30pm) ABSTRACT:  Virtual environments (VE) are virtual social spaces that provide powerful means for creating, activating and modifying virtual bodies—Avatars—without dependencies on biological factors,formal rules and explicit conventions. VE offer unlimited possibilities to create the desired body and express personal bodily preference in virtual sport spaces without restrictions regarding established roles and behavioural expectations. Such a VE is Second Life (SL) in which the user is represented by an Avatar. This study focuses on a virtual sport space: the Fitness Club of Second Life. It examines the rules and regulations of this virtual space along with the role of 26 Avatars as bodily representations, including their bodily behaviours-exercises-practices in the SL Fitness Club. The data for this study was selected through systematic observation of 26 Avatars (apx. 180 hours) during March, April and May 2015, followed by detailed descriptions of single phenomena. Regarding the structure of space and bodily behavior, the results indicate less differences between sport virtual spaces and sport physical spaces, the opposite of what we had originally assumed. According to the results, the Avatar Fitness Club appears to be a highly individualistic and narcissistic environment. Moreover, every user can perform his/her bodily activities in a rather liberating way, occasionally surpassing biological limitations. When the Avatars exercise they imitate the movements of the physical sport world, namely they mimic the physical body. Further studies are needed to show the influence of an Avatar’s performance-bodily exercises on the real user, the individual behind the computer screen. KEYWORDS: Avatars, Fitness Club, Second Life, bodily exercisesAlso see:https://www.conftool.pro/esa2017/index.php?page=browseSessions&print=head&form_session=1625
Arabatzis T. What’s in It for the Historian of Science? Reflections on the Value of Philosophy of Science for History of Science. International Studies in the Philosophy of Science [Internet]. 2017;31(1):69-82. Publisher's VersionAbstract
In this article, I explore the value of philosophy of science for history of science. I start by introducing a distinction between two ways of integrating history and philosophy of science: historical philosophy of science (HPS) and philosophical history of science (PHS). I then offer a critical discussion of Imre Lakatos’s project to bring philosophy of science to bear on historical interpretation. I point out certain flaws in Lakatos’s project, which I consider indicative of what went wrong with PHS in the past. Finally, I put forward my own attempt to bring out the historiographical potential of philosophy of science. Starting from Norwood Russell Hanson’s insight that historical studies of science involve metascientific concepts, I argue that philosophical reflection on those concepts can be (and, indeed, has been) historiographically fruitful. I focus on four issues (epistemic values, experimentation, scientific discovery and conceptual change) and discuss their significance and utility for historiographical practice.
Ziogas DC, Terpos E, Dimopoulos MA. When to recommend a second autograft in patients with relapsed myeloma?. Leukemia and Lymphoma [Internet]. 2017;58(4):781 - 787. WebsiteAbstract
In the current evolving landscape of myeloma therapies, no recommended salvage strategy exists for patients with relapsed multiple myeloma (MM) after initial successful autologous stem cell transplantation (ASCT) and therapeutic options extend from conventional chemotherapy and novel agents to second autologous and allogeneic transplants. In this article, we summarize the documented evidence about the utilization of second ASCT in patients with relapsed MM after a primary auto-graft and discuss the correct timing for such a salvage approach, the individual characteristics of patients who will benefit more, as well as the therapeutic role of second ASCT in the modern era of forthcoming anti-myeloma treatments. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
Ziogas DC, Terpos E, Dimopoulos MA. When to recommend a second autograft in patients with relapsed myeloma?. Leukemia and Lymphoma [Internet]. 2017;58(4):781 - 787. WebsiteAbstract
In the current evolving landscape of myeloma therapies, no recommended salvage strategy exists for patients with relapsed multiple myeloma (MM) after initial successful autologous stem cell transplantation (ASCT) and therapeutic options extend from conventional chemotherapy and novel agents to second autologous and allogeneic transplants. In this article, we summarize the documented evidence about the utilization of second ASCT in patients with relapsed MM after a primary auto-graft and discuss the correct timing for such a salvage approach, the individual characteristics of patients who will benefit more, as well as the therapeutic role of second ASCT in the modern era of forthcoming anti-myeloma treatments. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
Giovani C, Kamberidou I, Patsantaras N. ΑΝΑΖΗΤΩΝΤΑΣ ΤΟΥΣ ΠΑΡΑΓΟΝΤΕΣ ΠΟΥ ΣΥΜΒΑΛΛΟΥΝ ΣΤΗΝ ΕΚΔΗΛΩΣΗ ΤΟΥ ΦΑΙΝΟΜΕΝΟΥ ΤΟΥ ΕΚΦΟΒΙΣΜΟΥ ΣΤΟ ΜΑΘΗΜΑ ΤΗΣ ΦΥΣΙΚΗΣ ΑΓΩΓΗΣ (Bullying in physical education classes). Πρακτικά του 4ου Συνεδρίου Αθλητικής Επιστήμης «Η Φυσική Αγωγή και ο Αθλητισμός στο Σύγχρονο Κόσμο: Παιδεία - Κοινωνία – Πολιτισμός» σελ. 102. 2017;1(1):102.Abstract
 Ένα από τα σημαντικότερα ζητήματα που έχει να αντιμετωπίσει σήμερα η εκπαιδευτική κοινότητα είναι αυτό του εκφοβισμού (bullying). Ερευνητικά δεδομένα υπογραμμίζουν ότι το φαινόμενο του εκφοβισμού στο σχολικό περιβάλλον ανατροφοδοτείται με έναν περίπλοκο τρόπο και είναι άρρηκτα συνδεδεμένο με εξωσχολικούς παράγοντες όπως οι αλλαγές στη δομή της οικογένειας και στην ποιότητα των ενδο-οικογενειακών και διαπροσωπικών σχέσεων, η συνεχής και αυξανόμενη έκθεση των παιδιών στη βία τόσο αναφορικά με τα ΜΜΕ όσο και κατά την ενασχόλησή τους με συγκεκριμένα ηλεκτρονικά παιχνίδια κ.α. Από ένα μεγάλο αριθμό διερευνητικών προσεγγίσεων επισημαίνεται ότι η ποιότητα του σχολικού κλίματος, η σχολική συνοχή καθώς και ο άμεσα περιβάλλων χώρος του σχολείου παίζουν σημαντικό ρόλο στην εκδήλωση επιθετικών ενεργειών. Στον ελλαδικό χώρο, παρ’ όλο που έχουν πραγματοποιηθεί πολλές έρευνες για τον εκφοβισμό ως μορφή ενδοσχολικής βίας, δεν υπάρχουν ακόμα αρκετές μελέτες, που να διαπραγματεύονται και να διερευνούν το ζήτημα αυτό στις προοπτικές του μαθήματος της Φυσικής Αγωγής (ΦΑ). Η παρούσα μελέτη –ως επιμέρους προσπάθεια μιας εν εξελίξει εμπειρικής έρευνας— βασίζεται σε ανασκόπηση της σύγχρονης ερευνητικής βιβλιογραφίας και έχει σκοπό να αναδείξει και να επισημάνει τους σημαντικότερους  παράγοντες που συμβάλλουν στην εκδήλωση του εκφοβισμού στις προοπτικές του μαθήματος της ΦΑ στον ελληνικό χώρο. Σύμφωνα με τη διεθνή βιβλιογραφία το μάθημα ΦΑ συμβάλλει θετικά στην ομαλή κοινωνικοποίηση και ενσωμάτωση των μαθητών στο σχολείο. Στις προοπτικές αυτές επισημαίνεται ότι οι Καθηγητές/τριες Φυσικής Αγωγής διαδραματίζουν καθοριστικό ρόλο στη δημιουργία θετικού κλίματος εφαρμόζοντας στρατηγικές και προγράμματα διαχείρισης διαπροσωπικών σχέσεων και συγκρούσεων. Ωστόσο από την άλλη πλευρά όπως διαπιστώνεται από τις σχετικές με αυτό το ζήτημα έρευνες που πραγματοποιήθηκαν σε άλλες χώρες, οι αθλητικές ή παιγνιώδεις ομαδικές δραστηριότητες που κατ’ εξοχήν χρησιμοποιούνται ως εκπαιδευτικό εργαλείο στη ΦΑ, δημιουργούν ευκαιρίες για στοχοποίηση κάποιων μαθητών/τριών εξαιτίας, μεταξύ άλλων, κάποιων ατομικών χαρακτηριστικών (π.χ. σωματικό βάρος, σεξουαλικό προσανατολισμό, φύλο, μειωμένο επίπεδο κινητικών δεξιοτήτων)  τόσο από τους συμμαθητές/τριες όσο και από τον εκπαιδευτικό της ΦΑ. Η στοχοποίηση αυτής της μορφής αναδεικνύεται ως ένας καταλυτικός και ουσιαστικός παράγοντας εκδήλωσης εκφοβιστικών συμπεριφορών.  Όπως προκύπτει από τα διεθνή ερευνητικά δεδομένα η ΦΑ αποτελεί ένα μέσον –ανάλογα με τον τρόπο που το οργανώνουμε και το διαχειριζόμαστε— τόσο για την καλλιέργεια και εκδήλωση του φαινομένου του εκφοβισμού όσο και για την άμβλυνσή του.   Βιβλιογραφικές Πηγές Bejerot, S., J. Edgar & B.M. Humble, (2010), “Poor performance in physical education – a risk factor for bully victimization. A case–control study”. In Acta Pædiatrica, 100: 413–419 Hicky, C., H. (2008), “Physical education, sport and hyper-masculinity in schools”. In Sport, Education and Society, 13(2): 147-161 Kamberidou, I. (2012). New Realms of Agency: Promoting Peace Education and Gender Equity through Sport. In Sport Science and Physical Education, [Ed. Luminita Georgescu],  Encyclopedia of Life Support Systems, Eolss Publishers, Oxford ,UK. Developed under the Auspices of UNESCO Oliver, K.L. & M. Hamzeh (2010), “The boys won't let us play” fifth-grade mestizas challenge physical activity discourse at school”. In Research Quarterly for Exercise and Sport81(1): 38-51 
bullying_in_physical_education_by_giovani_kamberidou_patsantaras.pdf
αναλυτικές οδηγίες με τον τρόπο ψηφιακής υπογραφής. 2017.Abstract
Στην περίπτωση που ο χρήστης διαθέτει adobe acrobat ακολουθούν αναλυτικές οδηγίες με τον τρόπο ψηφιακής υπογραφής (digital sign) ενός pdf εγγράφου και συγκεκριμένα του εξαγόμενου pdf με την απογραφή του ΤΠΕ εξοπλισμού του σχολείου.
Μάζης Ιωάννης. Ἀπὸ τὸν Νikolas J. Spykman στὸν Alexandre Kojève: Τὸ ἄγνωστο ταξεῖδι στὴν ἀντίληψη τῆς ἀσφαλείας τῆς Δύσεως. Ἡμέρα Μνήμης τῶν 72 Χρόνων ἀπὸ τῆς λήξεως τοῦ Μεγάλου Πατριωτικοῦ Πολέμου. 2017.Abstract
Το παρόν κείμενο εξετάζει συγκριτικά τα απαιτήματα-συμπεράσματα της θεωρίας του N. J. Spyman (1943) με την απόρρητη έκθεση (1945) του καθηγητού της Σορβόννης Alexandre Kojève προς τον στρατηγό Charles André Joseph Marie de Gaulle, περί δημιουργίας της ΕΚΑΧ και μετάπειτα ΕΟΚ και ΕΕ, υπό το φως της δημιουργίας μιας "Λατινικής Αυτοκρατορίας" αποτελουμένης από την προεξάρχουσα εις αυτήν Γαλλία, την Ιταλία και την Ισπανία, με τις αποικίες τους, οι οποίες θα λειτουγούσαν ως ενδιάμεση ζώνη ασφαλείας μεταξύ της "Αγγλοσαξωνικής Αυτοκρατορίας" και τις Σλαβοορθοδόξου Σοβιετικής Αυτοκρατορίας.
1_xvii.pdf
Μάζης Ιωάννης. Γεωπολιτικὴ ἀνάλυσις τῶν Ρωσσο-Ἀμερικανικῶν ἐνεργειακῶν ἀνταγωνισμῶν στὸ Ὑποσύστημα τῶν Βαλκανίων ἐντὸς τοῦ Μείζονος Μεσογειακοῦ Συστήματος. Foreign Affairs, Hellenic Edition. 2017;(48).Abstract
Στὸ Γεωπολιτικὸ Σύμπλοκο τῆς Μεσογείου παρατηρεῖται τοὺς τελευταίους μῆνες μιὰ ἔντονη, ὅσο καὶ ἐπικίνδυνη, κινητικότητα στὸ τμῆμα τῶν ∆υτικῶν Βαλκανίων ἐντὸς τοῦ γεωπολιτικοῦ Ὑποσυστήματος τῶν Βαλκανίων. Ἡ χώρα μας ἔχει τὸ θλιβερὸν προνόμιον νὰ ἀποτελεῖ τὴν τομὴν τῶν δύο ἀσταθῶν Ὑποσυστημάτων τοῦ Μεσογειακοῦ Γεωπολιτικοῦ Συμπλόκου: α) τοῦ Ὑποσυστήματος τῶν Βαλκανίων καὶ β) τοῦ Ὑποσυστήματος Τουρκίας-Ἐγγύς Ἀνατολῆς. Θὰ ἀποδείξομε ἀφ' ἐνὸς ὅτι τὰ δύο αὐτὰ Ὑποσυστήματα εὑρίσκονται σὲ ἔντονη ὅσο καὶ ἀσταθῆ συλλειτουργία στὴν παροῦσα συγκυρία, καὶ ἀφ' ἑτέρου θὰ ἀναδειχθεῖ ὁ κύριος γεωπολιτικὸς παράγων, γενεσιουργὸς τῆς ἀσταθείας αὐτῆς, ὁ ὁποῖος εἶναι ἡ Ἐνεργειακὴ Ἀσφάλεια. Ἐπίσης θὰ καταδειχθοῦν οἱ βασικοὶ πόλοι διεθνοῦς ἰσχύος, ἡ Μόσχα καὶ ἡ Οὐάσιγκτων, ὁ νεοψυχροπολεμικοῦ τύπου ἀνταγωνισμὸς τῶν ὁποίων θέτει σὲ ἀποσταθεροποιητικὴ δυναμικὴ τὸ Γεωπολιτικὸ σύμπλοκο τῆς Μεσογείου μὲ κύρια ἑστία τὰ ∆υτικὰ Βαλκάνια. Ὁ ὅρος "νεοψυχροπολεμικοῦ τύπου" χρησιμοποιεῖται γιὰ νὰ τονισθεῖ τὸ γεγονὸς ὅτι ὑπάρχει σημαντικὴ ἰδεολογικὴ ἀπόστασις μεταξὺ τῶν δύο αὐτῶν πόλων (καὶ φυσικὰ —ἀλλὰ περισσότερον συγκεκαλυμμένος— μεταξὺ Οὐάσιγκτων καὶ Πεκίνου), ὅπως κατὰ τὴν περίοδον τοῦ Ψυχροῦ Πολέμου. Ἡ ἰδεολογικὴ διαφορὰ στὴν περίπτωση αὐτὴν ἔγκειται στὴν δυτικὴ κοσμοπολιτικὴ καὶ ἀκραίως νεοφιλελεύθερη δυτικὴ προσέγγιση καὶ τὴν ἐθνο-ταὐτοτικὴ συντηρητικὴ προσέγγιση τῆς Ἀνατολῆς, μὲ προεξάρχοντα πόλο τὴν Μόσχα. Τὸ θεωρητικὸ ὑπόβαθρο τῆς παρούσης ἀναλύσεως εἶναι αὐτὸ τῆς κλασικῆς ἀγγλοσαξωνικῆς γεωπολιτικῆς σχολῆς μὲ ὑπόδειγμα αὐτὸ τοῦ Ν. J. Spykman ὅπως ἐξελίχθηκε ἀπὸ τὶς προσεγγίσεις τοῦ Ζ. Brzezinsky καὶ ἡ μεθοδολογικὴ προσέγγισις αὐτὴ τῆς Συγχρόνου Συστημικῆς Γεωπολιτικῆς Ἀναλύσεως.
2._xix.pdf
Drikos S, Kountouris P, Somponis G. ΔΙΑΧΡΟΝΙΚΗ ΜΕΛΕΤΗ ΣΥΜΒΟΛΗΣ ΤΩΝ ΤΕΧΝΙΚΩΝ ΔΕΞΙΟΤΗΤΩΝ ΣΤΗΝ ΑΓΩΝΙΣΤΙΚΗ ΕΠΙΤΥΧΙΑ ΤΗΣ ΠΕΤΟΣΦΑΙΡΙΣΗΣ ΑΝΔΡΩΝ. In: 4o Συνέδριο Αθλητικής Επιστήμης, «Η Φυσική Αγωγή και ο Αθλητισμός στο σύγχρονο κόσμο: Παιδεία – Κοινωνία - Πολιτισμός». ΣΕΦΑΑ Αθήνας, 4-7 Μαΐου 2017, Αθήνα. http://sefaacongress.phed.uoa.gr/: School of Physical Education & Sport Science ATHENS; 2017. pp. 77-78. Publisher's VersionAbstract
Εισαγωγή:. Στηv Πετοσφαίριση η αγωνιστική απόδοση εξαρτάται από την επίδοση των αθλητών στις τεχνικές δεξιότητες του παιχνιδιού (Marcelino, Mesquita, & Alfonso, 2008) και η αθλητική επιτυχία μπορεί να ποσοτικοποιηθεί με βάση την αγωνιστική απόδοση (Lobietti, Michele, & Merni, 2006). Με τη χρήση δεδομένων από μία αγωνιστική περίοδο, βρέθηκε υψηλή συσχέτιση μεταξύ της αγωνιστικής επιτυχίας (σύνολο πόντων σε πρωτάθλημα), με το άθροισμα των δεικτών αποτελεσματικότητας σερβίς και επίθεσης (Drikos, Kountouris, Laios, & Laios, 2009). Η παρούσα μελέτη εξετάζει την αγωνιστική επιτυχία (τελική κατάταξη στην 1η τετράδα της κανονικής περιόδου) σε σχέση με την αγωνιστική απόδοση, στη διάρκεια 11 συνεχών αγωνιστικών περιόδων του πρωταθλήματος Πετοσφαίρισης Ανδρών Ελλάδος. Μέθοδος:. Τα δεδομένα προήλθαν από την καταγραφή της αγωνιστικής απόδοσης των ομάδων (Ν=131), που συμμετείχαν στις κανονικές αγωνιστικές περιόδους (2005- 6 έως 2015-16) των πρωταθλημάτων Α1 κατηγορίας Ανδρών, σε τέσσερις βασικές τεχνικές δεξιότητες του παιχνιδιού (επίθεση, σερβίς, υποδοχή σερβίς και μπλοκ). Η αξιολόγηση της εκτέλεσης των τεχνικών δεξιοτήτων πραγματοποιήθηκε με τακτική κλίμακα 6 επιπέδων. Η αξιοπιστία μεταξύ των βαθμολογητών ελέγχθηκε με σταθμισμένο δείκτη Κ Cohen και ήταν Adjusted Κ= .85, πολύ καλή (Altman, 1991). Η στατιστική επεξεργασία των δεδομένων έγινε μέσω πολυμεταβλητής ανάλυσης διακύμανσης και διακριτής ανάλυσης, για τον προσδιορισμό των διαφορών ανάμεσα στις ομάδες των θέσεων 1-4, 5-8 και 9-12 και των δεξιοτήτων που κατατάσσουν με επιτυχία τις παρατηρήσεις. Αποτελέσματα:. Υπήρξε στατιστικά σημαντική διαφορά των μέσων όρων στις ομάδες 1-4 σε σχέση με τις υπόλοιπες, σε όλες τις τεχνικές δεξιότητες, εκτός από την υποδοχή σερβίς και στις ομάδες 5-8 με τις αντίστοιχες 9-12 στην επίθεση μετά από υποδοχή σερβίς και στo μπλοκ. Οι μεταβλητές με συντελεστή συσχέτισης >|.3| με τη διαχωριστική συνάρτηση, ήταν οι δείκτες αποτελεσματικότητας σερβίς (-.42), επίθεσης μετά από υποδοχή σερβίς (.90), επίθεσης μετά από άμυνα (.60) Η διαχωριστική συνάρτηση κατέταξε με επιτυχία για το σύνολο του δείγματος το 72% των παρατηρήσεων Για τις θέσεις 1-4 η επιτυχημένη κατάταξη ήταν 87,5%, ενώ για τα γκρουπ 5-8 και 9-12 ήταν 65% αντίστοιχα.Συμπεράσματα: Οι ομάδες των θέσεων 1-4 αποδίδουν καλύτερα σε όλες τις δεξιότητες που κατακτούν πόντο. Η αγωνιστική επιτυχία μπορεί να ερμηνευθεί με τη χρήση των δεικτών αποτελεσματικότητας, λόγω της καλής προσαρμογής του μοντέλου.
Georgiou Y, Patsantaras N, Kamberidou I. Διευρευνώντας τις σχέσεις μεταξύ δρομικού κινήματος και τυπικά οργανωμένων αθλητικών θεσμών στην Ελληνική επικράτεια. Βιβλίο Πρακτικών (σελ. 97-98, 1η έκδοση) του 4ου Συνεδρίου Αθλητικής Επιστήμης «Η Φυσική Αγωγή και ο Αθλητισμός στο Σύγχρονο Κόσμο: Παιδεία - Κοινωνία- Πολιτισμός. 2017;(1):97-98. running_movememt._authentic_marathon.pdf conference_proceedings._praktika_synedrioy_1st_edition_may_2017.pdf
Εκπαίδευση και εκπαιδευτική μεταρρύθμιση: ιστορικο-συγκριτικές προσεγγίσεις. 1st ed. (Δημήτρης Φωτεινός, κ.α.). Athens, Greece: Gutenberg; 2017.
Μάζης Ιωάννης, Δωματιώτη Ξανθίππη, Δήγκας Άγης. Ἐφαρμογὴ Ἀπλῶν καὶ Σύνθετων Δεικτῶν τῶν Τεσσάρων Γεωπολιτικῶν Πυλώνων στὴν Μεθοδολογία τῆς Συστημικῆς Γεωπολιτικῆς Αναλύσεως: Ἡ Περίπτωση τῆς Συρίας. Civitas Gentium. 2017;5(2).Abstract
Η παρούσα επιστημονική δημοσίευση, αποτελεί εφαρμογή απλών και σύνθετων γεωπολιτικών δεικτών, των τεσσάρων γεωπολιτικών πυλώνων στη μεθοδολογία της συστημικής γεωπολιτικής αναλύσεως. Ως περίπτωση εξετάζεται η Συριακή Κρίση.
1._xviii.pdf
Μάζης Ιωάννης. Ἡ Ἀρμενικὴ γενοκτονία ὡς ἀποτελέσμα τῶν γεωστρατηγικῶν ἀνταγωνισμῶν τῶν μεγάλων δυνάμεων στὴν Εὐρύτερη Μέση Ἀνατολὴ. In: Ἡμέρα Μνήμης τῆς Ἀρμενικῆς Γενοκτονίας, 22 Ἀπριλίου 2017, Ἑταιρεία Μακεδονικῶν Σπουδῶν. Θεσσαλονίκη; 2017.Abstract
Ἡ κατάστασις σήμερα πιέζει γιὰ τὴ δημιουργίαν-πλησίον τῆς ἰσχυρᾶς καὶ εὐημερούσης οἰκονομικῶς Ἀρμενίας-καὶ ἑνὸς ἀνεξαρτήτου πλέον Κουρδιστάν. Τὸ νέο αὐτὸ κράτος λειτουργῶντας ὡς «buffer state/état tampon» μεταξὺ Ἀράβων, Ἰρανῶν, Σύρων καὶ Ἰρακινῶν καὶ ἐν συνδυασμῷ πρὸς μιὰ ἀπαραιτήτως ἰσχυρὰν Ἀρμενία καὶ τὸ ἤδη ἰσχυρὸ καὶ σταθερὸ ὡς πρὸς τὶς διεθνεῖς του σχέσεις Ἰσραήλ, μποροῦν νὰ ἐγγυηθοῦν τὸ ἀπαραίτητο καθεστὼς ἀσφαλείας στὴν Κεντρικὴ Ἀσία. Ἡ Ρωσσία τοῦ Ποῦτιν, ἡ ἀμερικὴ τῶν Ὀμπάμα καὶ Τρὰμπ ἀλλὰ καὶ τὸ Ἰσραὴλ τοῦ Νετανιάχου ἐπιθυμοῦν διακαῶς μιὰν ἀνάλογη λύση. Ἡ  καθεμία πλευρὰ γιὰ τοὺς δικούς της γεωστρατηγικοὺς λόγους. Ἡ Ρωσσία γιὰ νὰ ἀπομακρύνει τὸν ἰσλαμιστικὸν κίνδυνο ἀπὸ τὰ ἐδάφη τοῦ «ἐγγὺς ἐξωτερικοῦ»της στὴν Κεντρικὴ Ἀσία. Οἱ ΗΠΑ γιὰ νὰ ἀποκτήσουν ἕνα φερέγγυο σύμμαχο καὶ προβολέα ἰσχύος στὴν Μέση Ἀνατολή, στὸν Ἀραβοπερσικὸ Κόλπο καὶ τὸ κέντρο τοῦ ∆ρόμου τοῦ Μεταξιοῦ. Τὸ Ἰσραὴλ γιὰ νὰ ἀποκτήσει χερσαῖο στρατηγικὸ βάθος σὲ ἕνα ἐπισφαλὲς ἰρανο-ἀραβικὸ ἰσλαμιστικὸ περιβάλλον. Ἡ ἐγκατάλειψις τῆς εἰρήνης στὰ χέρια μιᾶς παντουρκιστικῆς τουρκικῆς πολιτικῆς, ἀπὸ πλευρᾶς ∆ύσεως, θὰ σημάνει τὴν ἔναρξη μιᾶς σειρᾶς ἁλυσιδωτῶν ἐκρήξεων μεταξὺ τῶν ἀλλοϋποβλεπομένων δρώντων στὴν περιοχή, ὅπως τὸ Ἰράν, τὸ Πακιστάν, ἡ Ρωσσία, ἡ Σ. Ἀραβία, ἡ Αἴγυπτος καὶ τὸ ἀπολύτως ἀσταθὲς Ἀφγανιστάν. Τὰ ἀποτελέσματα θὰ εἶναι δεινὰ γιὰ τὴν εἰρήνη καὶ τὸν δυτικὸ πολιτικὸ πολιτισμὸ εἰς τὴν γεωπολιτικὴν αὐτὴν ζώνη. Καὶ αὐτὸ διότι ὁ προϊὼν ἰσλαμιστικὸς χαρακτὴρ τῆς Ἀγκύρας ὁ ὁποῖος ἔχει ἐνταχθεῖ στὸ εὐρύτερο ριζοσπατικὸ ἰσλαμιστικὸ ὄχημα τῆς «διεθνοῦς» τῶν Ἀδελφῶν Μουσουλμάνων9, σίγουρα θὰ προωθήσει τὴν ἐξαγωγὴ τῆς «ἰσλαμικῆς ἐπαναστάσεως» καὶ τῶν ἱεροπολεμικῶν ἀντιλήψεων καὶ στὴν ζώνη τῶν Βαλκανίων. Στὴν φάση ὅμως αὐτὴν ἡ Τουρκία δὲν θὰ κατωρθώσει νὰ πείσει οὔτε κἂν τὸν ἑαυτόν της εἰς ὅ,τι ἀφορᾷ τὶς δημοκρατικές της πεποιθήσεις, καὶ ὁ Χάρτης τῆς Εὐρυτέρας Μέσης Ἀνατολῆς ἀναδιατάσσεται ἔχοντας αὐτὸ ὡς δεδομένο. Ἴσως τώρα ἦλθε ἡ ὥρα νὰ ἀντιληφθοῦν οἱ «μαθητευόμενοι μάγοι» τῶν διεθνῶν μητροπολιτικῶν ἐπιτελείων τὰ μέχρι σήμερα λάθη τους. Ἐλπίζομε ὅμως νὰ μὴ εἶναι εἶναι ἀργὰ καὶ γι' αὐτούς, ἀλλὰ κυρίως γιὰ ὁλόκληρη τὴν ἀνθρωπότητα. Ὁ συστηματικὸς διωγμὸς τῶν χριστιανικῶν πληθυσμῶν στὴν Μέση Ἀνατολὴ ἀπὸ τὶς ριζοσπαστικὲς ἰσλαμιστικὲς τάσεις καὶ ὀργανώσεις, οἱ ὁποῖες ἐξετράφησαν καὶ ἐξωπλίσθησαν ἀπὸ τὴν ∆ύση καὶ τοὺς συμμάχους τους στὴν Μέση Ἀνατολὴ ἐπιδεικνύουν τὴν κατεύθυνση πρὸς τὴν κεντρικὴ Ἀσία τῶν ἰσλαμιστικῶν βλέψεών τους. Ἀνάχωμα σὲ αὐτὲς τὶς βλέψεις στὸν Καύκασο καὶ τὴν περιοχὴ τῆς Κασπίας καὶ τοῦ Εὐξείνου Πόντου ἀποτελεῖ ἡ Ἀρμενία. Ἂν ἡ Ἀρμενία ὑποχωρήσει, τὰ Βαλκάνια εἶναι μιὰ χαμένη ὑπόθεσις γιὰ τὴν ∆ύση καὶ ἕνα νέο Ἐμιρᾶτο γιὰ τὸ ριζοσπαστικὸ Ἰσλὰμ τοῦ ΙSIS καὶ τῶν παρακλαδιῶν τῆς ἀλ Κάϊντα καὶ τῶν Ἀδελφῶν Μουσουλμάνων.
2._xviii.pdf
Kefi Chatzichamperi E, Kamberidou I, Patsantaras N. Η Φυσική Αγωγή και η Άθληση ως Παράγοντας Ενσωμάτωσης του Γυναικείου Φύλου στις Ανώτατες Στρατιωτικές Σχολές στην Ελλάδα (Gender and the Military in Gre. Πρακτικά του 4ου Συνεδρίου Αθλητικής Επιστήμης «Η Φυσική Αγωγή και ο Αθλητισμός στο Σύγχρονο Κόσμο: Παιδεία - Κοινωνία – Πολιτισμός», σελ. 96-97. 2017;1(1):96-97. 1._gender_and_the_military_by_chatzichamperi_kamberidou_patsantaras.pdf conference_proceedings._praktika_synedrioy_1st_edition_may_2017.pdf
Μάζης Ιωάννης. Ἡ Χρῆσις τῆς Γνώσεως στὶς γεωπολιτικὲς ἐπιδιώξεις τῶν κρατούντων τῆς γῆς. Ἀριστοτέλειον Πανεπιστήμιον Θεσσαλονίκης Ἐπιτροπὴ Κοινωνικῆς Πολιτικῆς καὶ ὑγιείας. 2017.Abstract
Ἡ γνῶσις τῆς γεωπολιτικῆς πραγματικότητος ἀπετέλεσε, ἀποτελεῖ καὶ θὰ ἀποτελεῖ πάντοτε πρόκληση πρὸς τοὺς πολιτικοὺς καὶ πνευματικοὺς ταγούς. Οἱ κρατοῦντες εἰς τὸν Πλανήτη διαθέτουν ἰσχυρὰ κέντρα μελέτης τῆς γεωπολιτικῆς πραγματικότητος, ὥστε λαμβάνοντες ὑπ' ὄψιν τὰ προκύπτοντα γεωπολιτικὰ ὑποδείγματα νὰ προβοῦν στὴν χάραξη τῶν ἀντιστοίχων ἡγεμονικῶν ἢ κυριαρχικῶν διεθνῶν στρατηγικῶν τους. Το παρόν κείμενο αναφέρεται στη χρήση της γνώσεως στις γεωπολιτικές επιδιώξεις των κρατούντων της γης.
1._xvi.pdf
Φωτεινός Δημήτρης. Ιστορία της εκπαίδευσης. Μια προσέγγιση στη γενεαλογία του θεσμού. 1st ed. Athens, Greece: Γρηγόρης; 2017 pp. 335. Publisher's VersionAbstract
Με το εγχείρημά μας αυτό προσπαθήσαμε να δώσουμε μια γενεαλογική διάσταση στην αφήγηση της ιστορίας της εκπαίδευσης. Αναφερθήκαμε σε δομικά ζητήματα (οικονομικοί και κοινωνικοί μετασχηματισμοί), σε θεσμικές ρυθμίσεις (κατασκευή της εκπαίδευσης μέσα από την απόσχισή της από άλλο προϋπάρχοντα θεσμό), σε πολιτικά προβλήματα, σε ιδέες που διαμορφώθηκαν από συγκεκριμένους διανοούμενους, σε συγκεκριμένες συνθήκες (είτε προσωπικές, είτε ευρύτερες). Προφανώς, η ιστορία δεν είναι πλήρης, με την έννοια ότι δεν αναφερθήκαμε σε «όλα» όσα συνέβησαν, δεν αναφέραμε όλους όσοι ενεπλέκησαν, δεν επιμείναμε σε κάθε λεπτομέρεια. Αυτό είναι ούτως ή άλλως αδύνατο. Η ιστορική αφήγηση είναι ένα νοηματικό σχήμα που καλύπτει υπό μία θεώρηση το παρελθόν. Είναι αδύνατο να γράψει κανείς για «όλα» όσα συνέβησαν: αν το κάνει θα είναι μια απλή γεγονοτογραφία. Αν επιχειρήσει να ερμηνεύσει, τότε αναγκαστικά θα περιοριστεί σε κάποια από τα συμβάντα (θα τα αναδείξει, δηλαδή, ως ιστορικά τεκμήρια). Άρα, εκ των πραγμάτων, δεν χρειάζεται να αναφερθεί σε «όλα». Αυτό που μπορούμε να δούμε ως ένα πρώτο συμπέρασμα μέσα από αυτό το αφήγημα της εκπαίδευσης είναι ότι η ανάγκη του ανθρώπου για να προσδιοριστεί είναι σημαντική, και αυτό προσπάθησε να κάνει στο διάβα της ιστορίας. Η εκπαίδευση φαίνεται να δίνει εκείνα τα στοιχεία της ταυτότητάς μας, με τα οποία αναγνωρίζουμε τον εαυτό μας, τους άλλους, το πλαίσιο στο οποίο κινούμαστε. Αυτή η ταυτότητα, ωστόσο, είναι, όπως διαμορφώνεται μέσα από την εκπαίδευση, μια επιβαλλόμενη ταυτότητα: εμπεριέχει προγενέστερες ρυθμίσεις, ρυθμίσεις άλλων σύγχρονών μας. Εμπεριέχει, όμως, και τις δικές μας προθέσεις, προτιμήσεις, ανάγκες, διαθέσεις. Εν κατακλείδι, θα μπορούσαμε να πούμε ότι η εκπαίδευση είναι ο χώρος όπου διαμορφώνεται διαλεκτικά (άρα και συγκρουσιακά) η ταυτότητά μας: είναι ένα διαρκές «γίγνεσθαι», στο οποίο συμμετέχουμε. Όσο πιο πολύ συμμετέχουμε, τόσο περισσότερο ολοκληρώνεται, εμπλουτίζεται, εμβαθύνεται η ταυτότητά μας. Συνεπώς, η εκπαίδευση είναι το ιδανικό πεδίο στο οποίο μπορεί να βρει έκφραση η «πράξη» (praxis), η πολιτική πράξη της διαπραγμάτευσης με τη γνώση.
Karella M, Kamberidou I, Papakostas C. Ο Οικονομικός Χαρακτήρας των Πανηγυριών: Επιτόπια Έρευνα στη Βάρη Αττικής. Ανακοίνωση στα Πρακτικά του 4ου Συνεδρίου Αθλητικής Επιστήμης «Η Φυσική Αγωγή και ο Αθλητισμός στο Σύγχρονο Κόσμο: Παιδεία - Κοινωνία – Πολ. 2017;1(Πρώτη έκδοση):92-93. conference_proceedings._praktika_synedrioy_1st_edition_may_2017.pdf
Κουμαριανός Θεόδωρος Ι. «Οι χοροι τών αγίων». In: ΙΣΤ΄ Πανελλήνιο Λειτουργικό Συμπόσιο Στελεχών Ιερών Mητροπόλεων, Λαμια, Σεπτέμβριος 2016. «Το Αγιολόγιον τής Εκκλησίας». Αποστολικὴ Διακονία τής Εκκλησίας τής Ελλάδος, Αθήναι; 2017. pp. 83-116.
Spenga A, Kamberidou I, Patsantaras N. Παράγοντες που επηρεάζουν τη συμμετοχή των μαθητριών Γυμνασίου και Λυκείου στο μάθημα της Φυσικής Αγωγής / Factors that influence female high school and junior high. Ανακοίνωση στα πρακτικά του 4ου Συνεδρίου Αθλητικής Επιστήμης «Η Φυσική Αγωγή και ο Αθλητισμός στο Σύγχρονο Κόσμο: Παιδεία - Κοινωνία – Πολ. 2017;1(1):99.Abstract
Σπέγγα, Α.,  Καμπερίδου,  Ει.,  & Πατσαντάρας, Ν. (2017).  "Παράγοντες που επηρεάζουν τη συμμετοχή των μαθητριών Γυμνασίου και Λυκείου στο μάθημα της Φυσικής Αγωγής / Factors that influence female high school and junior high school students’ participation in physical education classes". Ανακοίνωση στα πρακτικά του 4ου Συνεδρίου Αθλητικής Επιστήμης «Η Φυσική Αγωγή και ο Αθλητισμός στο Σύγχρονο Κόσμο: Παιδεία - Κοινωνία – Πολιτισμός», σελ. 99. Σχολή Επιστήμης Φυσικής Αγωγής και Αθλητισμού (ΣΕΦΑΑ), Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ).  
factors_that_influence_female_participation_spenga_kamberidou_patsantaras.pdf conference_proceedings._praktika_synedrioy_1st_edition_may_2017.pdf
Georgiou Y, Patsantaras N, Kamberidou I. ΣΤΑΣΕΙΣ ΤΩΝ ΦΟΙΤΗΤΩΝ/ΤΡΙΩΝ ΤΗΣ ΣΕΦΑΑ ΑΠΕΝΑΝΤΙ ΣΤΗΝ ΑΝΔΡΙΚΗ ΚΑΙ ΓΥΝΑΙΚΕΙΑ ΟΜΟΦΥΛΟΦΙΛΙΑ (Student Attitudes concerning Homosexuality, 2nd edition). Δεύτερη Έκδοση, Βιβλίο Πρακτικών του 4ου Συνεδρίου Αθλητικής Επιστήμης «Η Φυσική Αγωγή και ο Αθλητισμός στο Σύγχρονο Κόσμο: Παιδεία - Κοινωνία-Πολιτισμός. 2017;(2):92-93. student_attitudes_on_homosexuality.pdf
Kamberidou I. Το Ανεκμετάλλευτο Κοινωνικό Κεφάλαιο του Αθλητισμού: Η Γυναίκα Αθλήτρια (Δεύτερη Έκδοση), σελ. 33-37. Δεύτερη Έκδοση Βιβλίο Πρακτικών του 4ου Συνεδρίου Αθλητικής Επιστήμης «Η Φυσική Αγωγή και ο Αθλητισμός στο Σύγχρονο Κόσμο: Παιδεία - Κοινων. 2017;(2):33-37.Abstract
Καμπερίδου, Ειρήνη (2017). Το Ανεκμετάλλευτο Κοινωνικό Κεφάλαιο του Αθλητισμού: Η Γυναίκα Αθλήτρια. Δεύτερη Έκδοση Βιβλίο Πρακτικών του 4ου Συνεδρίου Αθλητικής Επιστήμης «Η Φυσική Αγωγή και ο Αθλητισμός στο Σύγχρονο Κόσμο: Παιδεία - Κοινωνία – Πολιτισμός», σελ. 33-37. Σχολή Επιστήμης Φυσικής Αγωγής & Αθλητισμού του Εθνικού και Καποδιστριακού Πανεπιστημίου Αθηνών (ΕΚΠΑ).............................................................:  ΠΕΡΙΛΗΨΗ -- ABSTRACT Οι έρευνες της έμφυλης διάστασης του κοινωνικού κεφαλαίου, μολονότι περιορισμένες, δείχνουν  ότι οι γυναίκες παίζουν σημαντικό ρόλο στην ανάπτυξη και αναπαραγωγή του, αναλαμβάνοντας κυρίως εθελοντικές δράσεις κοινωνικής προσφοράς και δράσεις κοινωνικής επιχειρηματικότητας που συντελούν καταλυτικά στην κοινωνική και οικονομική ευημερία. Επιπρόσθετα τα αποτελέσματα μεγάλου αριθμού ποιοτικών ερευνών, οι οποίες επικεντρώνουν το ενδιαφέρον τους στις αλληλεπιδράσεις μεταξύ  φύλου, αθλητισμού και επιχειρηματικότητας, δείχνουν μια θετική συσχέτιση μεταξύ των παραμέτρων αθλητική εμπειρία και επιτυχημένη ηγεσία. Η διερευνητική αυτή προσπάθεια  προσεγγίζει τον αθλητισμό στις προοπτικές της θεώρησης περί κοινωνικού κεφαλαίου. Βασιζόμενη σε μια ενδελεχή ανασκόπηση της διεθνούς σχετικής βιβλιογραφίας, και στα αποτελέσματα ποιοτικής έρευνας (8 ημι-δομημένες συνεντεύξεις) που διενεργήθηκε το 2016-2017, στοχεύει να εξηγήσει το ζήτημα της υποεκπροσώπησης των γυναικών όσον αφορά στις θέσεις διοικητικής ευθύνης στους αθλητικούς θεσμούς και κυρίως να αναδείξει τα εμπόδια που λειτουργούν καταλυτικά για την εμφάνιση αυτής της υποεκπροσώπησης.  Επικεντρώνει το ενδιαφέρον της στη γυναικεία συμμετοχή, που κατά κανόνα παραμένει μια  ανεκμετάλλευτη πηγή κοινωνικής ενέργειας και η οποία υπό συνθήκες μπορεί να διευκολύνει ποικίλες διαδικασίες κοινωνικής ενσωμάτωσης.  Επίσης διερευνά πιθανούς συσχετισμούς μεταξύ αθλητικής εμπειρίας και επιχειρηματικής δραστηριότητας. Υποκείμενα της έρευνας ήταν οκτώ εν ενεργεία και πρώην Ελληνίδες αθλήτριες, πρωταθλήτριες, ολυμπιονίκες και ακτιβίστριες—που έχουν διαπρέψει στην αθλητική ηγεσία και στο αθλητικό επιχειρείν. Τα αποτελέσματα δείχνουν ότι ο αθλητισμός προάγει δεξιότητες που είναι σημαντικές για την επιχειρηματικότητα και την ανάληψη δραστηριοτήτων διοικητικής μέριμνας και ευθύνης.  Ωστόσο οι γυναίκες που ενεργοποιούνται στο χώρο του αθλητισμού και επιδιώκουν να αναρριχηθούν σε θέσεις διοικητικής ευθύνης ή να ασκήσουν επιχειρηματικότητα στον χώρο αυτό, έχουν να υπερβούν πολλά εμπόδια. Μεταξύ άλλων επισημαίνονται: (1) οι προκαταλήψεις και τα στερεότυπα που ακόμα είναι κυρίαρχα και προκύπτουν από τις ανδροκεντρικές καταβολές του αθλητισμού, (2) η έλλειψη γυναικών μεντόρων, (3) η  έλλειψη γυναικών προτύπων, (4) οι άνισες ευκαιρίες εξέλιξης στην αθλητική ηγεσία σε σύγκριση με τους άνδρες, (5) η  έλλειψη ισορροπίας μεταξύ επαγγελματικής και ιδιωτικής/οικογενειακής ζωής. Απάντηση σε αυτή την υποεκπροσώπηση αποτελούν προγράμματα που προωθούν, προβάλλουν, και δημιουργούν γυναίκες μέντορες και κοινωνικά πρότυπα όπως εκείνο της Ελληνικής Ολυμπιακής Επιτροπής (ΕΟΕ) και του Συλλόγου Ελλήνων Ολυμπιονικών (ΣΕΟ) «Κάνουμε Χώρο για περισσότερες γυναίκες στην Αθλητική Συμμετοχή, την Προπονητική  Καθοδήγηση, και ειδικά τη Διοικητική Στελέχωση». Λέξεις κλειδιά: κοινωνική ενσωμάτωση, φύλο, αθλητισμός, ηγεσία, επιχειρηματικότητα, «έμφυλη κόπωση» (gender fatigue), «σπατάλη εσωτερικού ταλέντου» (wastage of internal talent),  «καμπύλη  ηλιθιότητας» (Stupid Curve), εξισορρόπηση επαγγελματικής και ιδιωτικής ζωής, γεφυρώνοντας το έμφυλο χάσμα     -Βλ. ολόκληρο το άρθρο / full pdf at http://www.tinyurl.com/k69yg56   στις σελίδες  31-40. -UoA scholar:  Το Ανεκμετάλλευτο Κοινωνικό Κεφάλαιο του Αθλητισμού: Η Γυναίκα Αθλήτρια , και στο -RG: https://www.researchgate.net/publication/316990102_To_Anekmetalleuto_Koinoniko_Kephalaio_tou_Athletismou_E_Gynaika_Athletria  
second_edition.defteri_ekdosipraktika_synedrioy_2i_ekdosi.pdf deltio_typoy.pdf
Καμπερίδου Ειρήνη. Το Ανεκμετάλλευτο Κοινωνικό Κεφάλαιο του Αθλητισμού: Η Γυναίκα Αθλήτρια. Πρακτικά του 4ου Συνεδρίου Αθλητικής Επιστήμης «Η Φυσική Αγωγή και ο Αθλητισμός στο Σύγχρονο Κόσμο: Παιδεία - Κοινωνία – Πολιτισμός», σελ. 31-40. 2017;1(1):31-40.Abstract
Οι έρευνες της έμφυλης διάστασης του κοινωνικού κεφαλαίου, μολονότι περιορισμένες, δείχνουν  ότι οι γυναίκες παίζουν σημαντικό ρόλο στην ανάπτυξη και αναπαραγωγή του, αναλαμβάνοντας κυρίως εθελοντικές δράσεις κοινωνικής προσφοράς και δράσεις κοινωνικής επιχειρηματικότητας που συντελούν καταλυτικά στην κοινωνική και οικονομική ευημερία. Επιπρόσθετα τα αποτελέσματα μεγάλου αριθμού ποιοτικών ερευνών, οι οποίες επικεντρώνουν το ενδιαφέρον τους στις αλληλεπιδράσεις μεταξύ  φύλου, αθλητισμού και επιχειρηματικότητας, δείχνουν μια θετική συσχέτιση μεταξύ των παραμέτρων αθλητική εμπειρία και επιτυχημένη ηγεσία. Η διερευνητική αυτή προσπάθεια  προσεγγίζει τον αθλητισμό στις προοπτικές της θεώρησης περί κοινωνικού κεφαλαίου. Βασιζόμενη σε μια ενδελεχή ανασκόπηση της διεθνούς σχετικής βιβλιογραφίας, και στα αποτελέσματα ποιοτικής έρευνας (8 ημι-δομημένες συνεντεύξεις) που διενεργήθηκε το 2016-2017, στοχεύει να εξηγήσει το ζήτημα της υποεκπροσώπησης των γυναικών όσον αφορά στις θέσεις διοικητικής ευθύνης στους αθλητικούς θεσμούς και κυρίως να αναδείξει τα εμπόδια που λειτουργούν καταλυτικά για την εμφάνιση αυτής της υποεκπροσώπησης.  Επικεντρώνει το ενδιαφέρον της στη γυναικεία συμμετοχή, που κατά κανόνα παραμένει μια  ανεκμετάλλευτη πηγή κοινωνικής ενέργειας και η οποία υπό συνθήκες μπορεί να διευκολύνει ποικίλες διαδικασίες κοινωνικής ενσωμάτωσης.  Επίσης διερευνά πιθανούς συσχετισμούς μεταξύ αθλητικής εμπειρίας και επιχειρηματικής δραστηριότητας. Υποκείμενα της έρευνας ήταν οκτώ εν ενεργεία και πρώην Ελληνίδες αθλήτριες, πρωταθλήτριες, ολυμπιονίκες και ακτιβίστριες—που έχουν διαπρέψει στην αθλητική ηγεσία και στο αθλητικό επιχειρείν. Τα αποτελέσματα δείχνουν ότι ο αθλητισμός προάγει δεξιότητες που είναι σημαντικές για την επιχειρηματικότητα και την ανάληψη δραστηριοτήτων διοικητικής μέριμνας και ευθύνης.  Ωστόσο οι γυναίκες που ενεργοποιούνται στο χώρο του αθλητισμού και επιδιώκουν να αναρριχηθούν σε θέσεις διοικητικής ευθύνης ή να ασκήσουν επιχειρηματικότητα στον χώρο αυτό, έχουν να υπερβούν πολλά εμπόδια. Μεταξύ άλλων επισημαίνονται: (1) οι προκαταλήψεις και τα στερεότυπα που ακόμα είναι κυρίαρχα και προκύπτουν από τις ανδροκεντρικές καταβολές του αθλητισμού, (2) η έλλειψη γυναικών μεντόρων, (3) η  έλλειψη γυναικών προτύπων, (4) οι άνισες ευκαιρίες εξέλιξης στην αθλητική ηγεσία σε σύγκριση με τους άνδρες, (5) η  έλλειψη ισορροπίας μεταξύ επαγγελματικής και ιδιωτικής/οικογενειακής ζωής. Απάντηση σε αυτή την υποεκπροσώπηση αποτελούν προγράμματα που προωθούν, προβάλλουν, και δημιουργούν γυναίκες μέντορες και κοινωνικά πρότυπα όπως εκείνο της Ελληνικής Ολυμπιακής Επιτροπής (ΕΟΕ) και του Συλλόγου Ελλήνων Ολυμπιονικών (ΣΕΟ) «Κάνουμε Χώρο για περισσότερες γυναίκες στην Αθλητική Συμμετοχή, την Προπονητική  Καθοδήγηση, και ειδικά τη Διοικητική Στελέχωση».   Λέξεις κλειδιά: κοινωνική ενσωμάτωση, φύλο, αθλητισμός, ηγεσία, επιχειρηματικότητα, «έμφυλη κόπωση» (gender fatigue), «σπατάλη ταλέντου» (wastage of talent),  «καμπύλη  ηλιθιότητας» (Stupid Curve), εξισορρόπηση επαγγελματικής και ιδιωτικής ζωής  
conference_proceedings._praktika_synedrioy_1st_edition_may_2017.pdf letter_of_acceptance_april_14_2017.pdf symposio_koinoniologias_toy_athlitismoy_metaneoterikes_proseggiseis_tis_athlitikis_drastiriotitas_kai_tis_fysikis_agogis.pdf
2016
Antonopoulou G, Magrioti V, Kokotou MG, Nikolaou A, Barbayianni E, Mouchlis VD, Dennis EA, Kokotos G. 2-Oxoamide inhibitors of cytosolic group IVA phospholipase A2 with reduced lipophilicity. Bioorganic and Medicinal Chemistry. 2016;24:4544-4554.Abstract
Cytosolic GIVA phospholipase A2 (GIVA cPLA2) initiates the eicosanoid pathway of inflammation and thus inhibitors of this enzyme constitute novel potential agents for the treatment of inflammatory diseases. Traditionally, GIVA cPLA2 inhibitors have suffered systemically from high lipophilicity. We have developed a variety of long chain 2-oxoamides as inhibitors of GIVA PLA2. Among them, AX048 was found to produce a potent analgesic effect. We have now reduced the lipophilicity of AX048 by replacing the long aliphatic chain with a chain containing an ether linked aromatic ring with in vitro inhibitory activities similar to AX048.
Anagnostaki L, Pavlopoulos V, Obradović J, Masten A, Motti-Stefanidi F. Academic resilience of immigrant youth in Greek schools: Personal and family resources. European Journal of Developmental Psychology. 2016;13(3):377-393.
Papaioannou TG, Karageorgopoulou TD, Sergentanis TN, Protogerou AD, Psaltopoulou T, Sharman JE, Weber T, Blacher J, Daskalopoulou SS, Wassertheurer S, et al. Accuracy of commercial devices and methods for noninvasive estimation of aortic systolic blood pressure a systematic review and meta-analysis of invasive validation studies. Journal of Hypertension [Internet]. 2016;34(7):1237 - 1248. Website
Rousanoglou E, Noutsos K, Pappas A, Bogdanis G, Vagenas G, Bayios I, Bountolos K. Alterations of vertical jump mechanics after a half-marathon mountain running race. Journal of Sports Science and Medicine [Internet]. 2016;15(2):277-286. Publisher's VersionAbstract
The fatiguing effect of long-distance running has been examined in the context of a variety of parameters. However, there is scarcity of data regarding its effect on the vertical jump mechanics. The purpose of this study was to investigate the alterations of countermovement jump (CMJ) mechanics after a half-marathon mountain race. Twenty-seven runners performed CMJs before the race (Pre), immediately after the race (Post 1) and five minutes after Post 1 (Post 2). Instantaneous and ensemble-average analysis focused on jump height and, the maximum peaks and time-to-maximum peaks of: Displacement, vertical force (Fz), anterior-posterior force (Fx), Velocity and Power, in the eccentric (tECC) and concentric (tCON) phase of the jump, respectively. Repeated measures ANOVAs were used for statistical analysis (p ≤ 0.05). The jump height decrease was significant in Post 2 (-7.9%) but not in Post 1 (-4.1%). Fx and Velocity decreased significantly in both Post 1 (only in tECC) and Post 2 (both tECC and tCON). Α timing shift of the Fz peaks (earlier during tECC and later during tCON) and altered relative peak times (only in tECC) were also observed. Ensemble-average analysis revealed several time intervals of significant post-race alterations and a timing shift in the Fz-Velocity loop. An overall trend of lowered post-race jump output and mechanics was characterised by altered jump timing, restricted anterior-posterior movement and altered force-velocity relations. The specificity of mountain running fatigue to eccentric muscle work, appears to be reflected in the different time order of the post-race reductions, with the eccentric phase reductions preceding those of the concentric one. Thus, those who engage in mountain running should particularly consider downhill training to optimise eccentric muscular action.
rousanoglou_et_al._2016_-_jssm.pdf
Aissopou EK, Argyris AA, Nasothimiou EG, Konstantonis GD, Tampakis K, Tentolouris N, Papathanassiou M, Theodossiadis PG, Papaioannou TG, Stehouwer CDA, et al. Ambulatory Aortic Stiffness Is Associated With Narrow Retinal Arteriolar Caliber in Hypertensives: The SAFAR Study. American Journal of Hypertension [Internet]. 2016;29(5):626 - 633. Website
Weisel KC, Dimopoulos MA, Moreau P, Lacy MQ, Song KW, Delforge M, Karlin L, Goldschmidt H, Banos A, Oriol A, et al. Analysis of renal impairment in MM-003, a phase III study of pomalidomide + low‐dose dexamethasone versus high‐dose dexamethasone in refractory or relapsed and refractory multiple myeloma. Haematologica [Internet]. 2016;101(7):872 - 878. WebsiteAbstract
Pomalidomide + low-dose dexamethasone is effective and well tolerated for refractory or relapsed and refractory multiple myeloma after bortezomib and lenalidomide failure. The phase III trial MM-003 compared pomalidomide + low-dose dexamethasone with high-dose dexamethasone. This subanalysis grouped patients by baseline creatinine clearance ≥ 30 - < 60 mL/min (n=93, pomalidomide + low-dose dexamethasone; n=56, high-dose dexamethasone) or ≥ 60 mL/min (n=205, pomalidomide + low-dose dexamethasone; n=93, high-dose dexamethasone). Median progression-free survival was similar for both subgroups and favored pomalidomide + low-dose dexamethasone versus high-dose dexamethasone: 4.0 versus 1.9 months in the group with baseline creatinine clearance ≥ 30 - < 60 mL/min (P<0.001) and 4.0 versus 2.0 months in the group with baseline creatinine clearance ≥ 60 mL/min (P<0.001). Median overall survival for pomalidomide + low-dose dexamethasone versus high-dose dexamethasone was 10.4 versus 4.9 months (P=0.030) and 15.5 versus 9.2 months (P=0.133), respectively. Improved renal function, defined as an increase in creatinine clearance from < 60 to ≥ 60 mL/min, was similar in pomalidomide + low-dose dexamethasone and high-dose dexamethasone patients (42% and 47%, respectively). Improvement in progression-free and overall survival in these patients was comparable with that in patients without renal impairment. There was no increase in discontinuations of therapy, dose modifications, and adverse events in patients with moderate renal impairment. Pomalidomide at a starting dose of 4 mg + low-dose dexamethasone is well tolerated in patients with refractory or relapsed and refractory multiple myeloma, and of comparable efficacy if moderate renal impairment is present. © 2016 Ferrata Storti Foundation.
Matsangouras IT, Nastos PT, Bluestein HB, Pytharoulis I, Papachristopoulou K, Miglietta MM. Analysis of waterspout environmental conditions and of parent-storm behaviour based on satellite data over the southern Aegean Sea of Greece. International Journal of Climatology [Internet]. 2016. Website
Magkoutis NA, Fradi S, Azmoun A, Ramadan R, Ouanes SB, Vavuranakis M, Vrachatis DA, Papaioannou TG, Tousoulis D, Ghostine S. Antiplatelet therapy in TAVI: Current clinical practice and recommendations. Current Pharmaceutical Design [Internet]. 2016;22(13):1888 - 1895. Website
Papaioannou TG, Karatzi K, Psaltopoulou T, Tousoulis D. Arterial ageing: Major nutritional and life-style effects. Ageing Research Reviews [Internet]. 2016. Website
Kontakiotis, G., Mortyn, P.G., Antonarakou, A., Drinia, H. Assessing the reliability of foraminiferal Mg/Ca thermometry by comparing field-samples and culture experiments: a review. Geological Quarterly [Internet]. 2016;60(3). Publisher's Version
Triantafyllou N, Thoda P, Armeni E, Rizos D, Kaparos G, Augoulea A, Alexandrou A, Creatsa M, Tsivgoulis G, Artemiades A, et al. Association of sex hormones and glucose metabolism with the severity of multiple sclerosis. International Journal of Neuroscience [Internet]. 2016;126:797-804. Website
Burnetas A, Kanavetas O, Katehakis MN. ASYMPTOTICALLY OPTIMAL MULTI-ARMED BANDIT POLICIES UNDER A COST CONSTRAINT. Probability in the Engineering and Informational Sciences [Internet]. 2016:1-27. WebsiteAbstract
We consider the multi-armed bandit problem under a cost constraint. Successive samples from each population are i.i.d. with unknown distribution and each sample incurs a known population-dependent cost. The objective is to design an adaptive sampling policy to maximize the expected sum of n samples such that the average cost does not exceed a given bound sample-path wise. We establish an asymptotic lower bound for the regret of feasible uniformly fast convergent policies, and construct a class of policies, which achieve the bound. We also provide their explicit form under Normal distributions with unknown means and known variances. Copyright © Cambridge University Press 2016
Dimopoulos MA, Sonneveld P, Sun H. The author and colleagues reply: Bueno. New England Journal of Medicine [Internet]. 2016;375(25):2497 - 2498. Website
Dimopoulos MA, Sonneveld P, Sun H. The author and colleagues reply: Bueno. New England Journal of Medicine [Internet]. 2016;375(25):2497 - 2498. Website
Krys K, Vauclair C-M, Capaldi CA, Lun VM-C, Bond MH, Domínguez-Espinosa A, Torres C, Lipp OV, Manickam SLS, Xing C. Be careful where you smile: culture shapes judgments of intelligence and honesty of smiling individuals. Journal of Nonverbal Behavior. 2016;40(2):101-116.
Vrontaki E, Melagraki G, Afantitis A, Mavromoustakos T. Beta-thalassaemia and therapeutic approaches. Pharmakeftiki [Internet]. 2016;28(3):108 - 116. Website
MOISSETTE, P., KOSKERIDOU, E., Drinia, H., Cornee, J.-J. Biofacies in warm-temperate siliciclastic deposits – Insights from the Early Pleistocene of the eastern Mediterranean (Rhodes, Greece). Geological Magazine [Internet]. 2016;153:61-83. Publisher's Version
Koukoulitsa C, Villalonga-Barber C, Csonka R, Alexi X, Leonis G, Dellis D, Hamelink E, Belda O, Steele BR, Micha-Screttas M, et al. Biological and computational evaluation of resveratrol inhibitors against Alzheimers disease. Journal of Enzyme Inhibition and Medicinal Chemistry [Internet]. 2016;31(1):67 - 77. Website
Pafilis P, Meiri S, Sagonas K, Karakasi D, Kourelou E, Valakos ED. Body size affects digestive performance in a Mediterranean lizard. The Herpetological Journal. 2016;26(3):199-205.
Dimopoulos MA, Roussou M, Gavriatopoulou M, Psimenou E, Eleutherakis-Papaiakovou E, Migkou M, Matsouka C, Mparmparousi D, Gika D, Kafantari E, et al. Bortezomib-based triplets are associated with a high probability of dialysis independence and rapid renal recovery in newly diagnosed myeloma patients with severe renal failure or those requiring dialysis. American Journal of Hematology [Internet]. 2016;91(5):499 - 502. WebsiteAbstract
Renal failure (RF) is a common and severe complication of symptomatic myeloma, associated with significant morbidity and mortality. Such patients are commonly excluded from clinical trials. Bortezomib/dexamethasone (VD)-based regimens are the backbone of the treatment of newly diagnosed MM patients who present with severe RF even those requiring dialysis. We analyzed the outcomes of 83 consecutive bortezomib-treated patients with severe RF (eGFR<30 ml/min/1.73 m2), of which 31 (37%) required dialysis. By IMWG renal response criteria, 54 (65%) patients achieved at least MRrenal, including CRrenal in 35% and PRrenal in 12%. Triplet combinations (i.e., VD plus a third agent) versus VD alone were associated with higher rates of renal responses (72 vs. 50%; P=0.06). Fifteen of the 31 (48%) patients became dialysis independent within a median of 217 days (range 11-724). Triplets were associated with a higher probability of dialysis discontinuation (57 vs. 35%). Serum free light chain (sFLC) level ≥11,550 mg/L was associated with lower rates of major renal response, longer time to major renal response, lower probability, and longer time to dialysis discontinuation. Rapid myeloma response (≥PR within the first month) was also associated with higher rates of renal response. Patients who became dialysis-independent had longer survival than those remaining on dialysis. In conclusion, VD-based triplets are associated with a significant probability of renal response and dialysis discontinuation, improving the survival of patients who became dialysis independent. Rapid disease response is important for renal recovery and sFLCs are predictive of the probability and of the time required for renal response. © 2016 Wiley Periodicals, Inc.
Dimopoulos MA, Roussou M, Gavriatopoulou M, Psimenou E, Eleutherakis-Papaiakovou E, Migkou M, Matsouka C, Mparmparousi D, Gika D, Kafantari E, et al. Bortezomib-based triplets are associated with a high probability of dialysis independence and rapid renal recovery in newly diagnosed myeloma patients with severe renal failure or those requiring dialysis. American Journal of Hematology [Internet]. 2016;91(5):499 - 502. WebsiteAbstract
Renal failure (RF) is a common and severe complication of symptomatic myeloma, associated with significant morbidity and mortality. Such patients are commonly excluded from clinical trials. Bortezomib/dexamethasone (VD)-based regimens are the backbone of the treatment of newly diagnosed MM patients who present with severe RF even those requiring dialysis. We analyzed the outcomes of 83 consecutive bortezomib-treated patients with severe RF (eGFR<30 ml/min/1.73 m2), of which 31 (37%) required dialysis. By IMWG renal response criteria, 54 (65%) patients achieved at least MRrenal, including CRrenal in 35% and PRrenal in 12%. Triplet combinations (i.e., VD plus a third agent) versus VD alone were associated with higher rates of renal responses (72 vs. 50%; P=0.06). Fifteen of the 31 (48%) patients became dialysis independent within a median of 217 days (range 11-724). Triplets were associated with a higher probability of dialysis discontinuation (57 vs. 35%). Serum free light chain (sFLC) level ≥11,550 mg/L was associated with lower rates of major renal response, longer time to major renal response, lower probability, and longer time to dialysis discontinuation. Rapid myeloma response (≥PR within the first month) was also associated with higher rates of renal response. Patients who became dialysis-independent had longer survival than those remaining on dialysis. In conclusion, VD-based triplets are associated with a significant probability of renal response and dialysis discontinuation, improving the survival of patients who became dialysis independent. Rapid disease response is important for renal recovery and sFLCs are predictive of the probability and of the time required for renal response. © 2016 Wiley Periodicals, Inc.
Evangelinos M, Martzoukou O, Chorozian K, Amillis S, Diallinas G. BsdA(Bsd2) -dependent vacuolar turnover of a misfolded version of the UapA transporter along the secretory pathway: Prominent role of selective autophagy. Mol Microbiol. 2016.Abstract
Transmembrane proteins translocate co-translationally in the endoplasmic reticulum (ER) membrane and traffic as vesicular cargoes, via the Golgi, in their final membrane destination. Misfolding in the ER leads to protein degradation basically through the ERAD/proteasome system. Here, we use a mutant version of the purine transporter UapA (ΔR481) to show that specific misfolded versions of plasma membrane cargoes undergo vacuolar turnover prior to localization in the plasma membrane. We show that non-endocytic vacuolar turnover of ΔR481 is dependent on BsdA(Bsd2) , an ER transmembrane adaptor of HulA(Rsp5) ubiquitin ligase. We obtain in vivo evidence that BsdA(Bsd2) interacts with HulA(Rsp5) and ΔR481, primarily in the ER. Importantly, accumulation of ΔR481 in the ER triggers delivery of the selective autophagy marker Atg8 in vacuoles along with ΔR481. Genetic block of autophagy (atg9Δ, rabO(ts) ) reduces, but does not abolish, sorting of ΔR481 in the vacuoles, suggesting that a fraction of the misfolded transporter might be redirected for vacuolar degradation via the Golgi. Our results support that multiple routes along the secretory pathway operate for the detoxification of Aspergillus nidulans cells from misfolded membrane proteins, and that BsdA is key factor for marking specific misfolded cargoes. This article is protected by copyright. All rights reserved.
Karakurt S, Kellici TF, Mavromoustakos T, Tzakos AG, Yilmaz M. Calixarenes in lipase biocatalysis and cancer therapy. Current Organic Chemistry [Internet]. 2016;20(10):1043 - 1057. Website
Dimopoulos MA, Moreau P, Palumbo A, Chng W-J, Feng S. Carfilozomib versus bortezomib for relapsed or refractory myeloma – Authors' reply. The Lancet Oncology [Internet]. 2016;17(4):e126. Website
Dimopoulos MA, Moreau P, Palumbo A, Chng W-J, Feng S. Carfilozomib versus bortezomib for relapsed or refractory myeloma – Authors' reply. The Lancet Oncology [Internet]. 2016;17(4):e126. Website
Dimopoulos MA, Moreau P, Palumbo A, Joshua D, Pour L, Hájek R, Facon T, Ludwig H, Oriol A, Goldschmidt H, et al. Carfilzomib and dexamethasone versus bortezomib and dexamethasone for patients with relapsed or refractory multiple myeloma (ENDEAVOR): And randomised, phase 3, open-label, multicentre study. The Lancet Oncology [Internet]. 2016;17(1):27 - 38. WebsiteAbstract
Background: Bortezomib with dexamethasone is a standard treatment option for relapsed or refractory multiple myeloma. Carfilzomib with dexamethasone has shown promising activity in patients in this disease setting. The aim of this study was to compare the combination of carfilzomib and dexamethasone with bortezomib and dexamethasone in patients with relapsed or refractory multiple myeloma. Methods: In this randomised, phase 3, open-label, multicentre study, patients with relapsed or refractory multiple myeloma who had one to three previous treatments were randomly assigned (1:1) using a blocked randomisation scheme (block size of four) to receive carfilzomib with dexamethasone (carfilzomib group) or bortezomib with dexamethasone (bortezomib group). Randomisation was stratified by previous proteasome inhibitor therapy, previous lines of treatment, International Staging System stage, and planned route of bortezomib administration if randomly assigned to bortezomib with dexamethasone. Patients received treatment until progression with carfilzomib (20 mg/m2 on days 1 and 2 of cycle 1; 56 mg/m2 thereafter; 30 min intravenous infusion) and dexamethasone (20 mg oral or intravenous infusion) or bortezomib (1·3 mg/m2; intravenous bolus or subcutaneous injection) and dexamethasone (20 mg oral or intravenous infusion). The primary endpoint was progression-free survival in the intention-to-treat population. All participants who received at least one dose of study drug were included in the safety analyses. The study is ongoing but not enrolling participants; results for the interim analysis of the primary endpoint are presented. The trial is registered at ClinicalTrials.gov, number NCT01568866. Findings: Between June 20, 2012, and June 30, 2014, 929 patients were randomly assigned (464 to the carfilzomib group; 465 to the bortezomib group). Median follow-up was 11·9 months (IQR 9·3-16·1) in the carfilzomib group and 11·1 months (8·2-14·3) in the bortezomib group. Median progression-free survival was 18·7 months (95% CI 15·6-not estimable) in the carfilzomib group versus 9·4 months (8·4-10·4) in the bortezomib group at a preplanned interim analysis (hazard ratio [HR] 0·53 [95% CI 0·44-0·65]; p<0·0001). On-study death due to adverse events occurred in 18 (4%) of 464 patients in the carfilzomib group and in 16 (3%) of 465 patients in the bortezomib group. Serious adverse events were reported in 224 (48%) of 463 patients in the carfilzomib group and in 162 (36%) of 456 patients in the bortezomib group. The most frequent grade 3 or higher adverse events were anaemia (67 [14%] of 463 patients in the carfilzomib group vs 45 [10%] of 456 patients in the bortezomib group), hypertension (41 [9%] vs 12 [3%]), thrombocytopenia (39 [8%] vs 43 [9%]), and pneumonia (32 [7%] vs 36 [8%]). Interpretation: For patients with relapsed or refractory multiple myeloma, carfilzomib with dexamethasone could be considered in cases in which bortezomib with dexamethasone is a potential treatment option. Funding: Onyx Pharmaceuticals, Inc., an Amgen subsidiary. © 2016 Elsevier Ltd.
Ziogas DC, Terpos E, Kastritis E, Dimopoulos MA. Carfilzomib for treating myeloma. Expert Opinion on Orphan Drugs [Internet]. 2016;4(9):989 - 999. WebsiteAbstract
Introduction: Carfilzomib, a second-generation proteasome inhibitor, has been increasingly used in relapsed/refractory multiple myeloma (MM) since its initial approval by the Food and Drug Administration in 2012, either as a single agent or in combination with other known anti-myeloma treatments. Based on its efficacy and safety profile in the relapsed/refractory setting, carfilzomib is currently evaluated in patients with de novo MM. Areas covered: Here, we will shed some light on the introduction of carfilzomib as an effective anti-myeloma treatment, presenting its mechanism of action, its response rates and adverse events, as well as a summary of all clinical trials evaluating current dosage and schedule of administration. We will follow the entire path of drug’s development from the bench of preclinical studies to the market and bedside delivery. Revising the published evidence, we will try to answer all questions raised about the novel drug, expressing in parallel our site experience. Expert opinion: Carfilzomib, alone or in combination with other agents, is a welcome therapeutic option for MM patients with a well-defined toxicity profile. Results of ongoing trials are expected in order to update drug indications and maximize its therapeutic benefits in patients with refractory/relapse MM. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
Ziogas DC, Terpos E, Kastritis E, Dimopoulos MA. Carfilzomib for treating myeloma. Expert Opinion on Orphan Drugs [Internet]. 2016;4(9):989 - 999. WebsiteAbstract
Introduction: Carfilzomib, a second-generation proteasome inhibitor, has been increasingly used in relapsed/refractory multiple myeloma (MM) since its initial approval by the Food and Drug Administration in 2012, either as a single agent or in combination with other known anti-myeloma treatments. Based on its efficacy and safety profile in the relapsed/refractory setting, carfilzomib is currently evaluated in patients with de novo MM. Areas covered: Here, we will shed some light on the introduction of carfilzomib as an effective anti-myeloma treatment, presenting its mechanism of action, its response rates and adverse events, as well as a summary of all clinical trials evaluating current dosage and schedule of administration. We will follow the entire path of drug’s development from the bench of preclinical studies to the market and bedside delivery. Revising the published evidence, we will try to answer all questions raised about the novel drug, expressing in parallel our site experience. Expert opinion: Carfilzomib, alone or in combination with other agents, is a welcome therapeutic option for MM patients with a well-defined toxicity profile. Results of ongoing trials are expected in order to update drug indications and maximize its therapeutic benefits in patients with refractory/relapse MM. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
Avet-Loiseau H, Fonseca R, Siegel D, Dimopoulos MA, Špička I, Masszi T, Hájek R, Rosiñol L, Goranova-Marinova V, Mihaylov G, et al. Carfilzomib significantly improves the progression-free survival of high-risk patients in multiple myeloma. Blood [Internet]. 2016;128(9):1174 - 1180. WebsiteAbstract
The presence of certain high-risk cytogenetic abnormalities, such as translocations (4;14) and (14;16) and deletion (17p), are known to have a negative impact on survival in multiple myeloma (MM). The phase 3 study ASPIRE (N = 792) demonstrated that progression-free survival (PFS) was significantly improved with carfilzomib, lenalidomide, and dexamethasone (KRd), compared with lenalidomide and dexamethasone (Rd) in relapsed MM. This preplanned subgroup analysis of ASPIRE was conducted to evaluate KRd vs Rd by baseline cytogenetics according to fluorescence in situ hybridization. Of 417 patients with known cytogenetic risk status, 100 patients (24%) were categorized with high-risk cytogenetics (KRd, n548; Rd, n552) and 317 (76%) were categorized with standard-risk cytogenetics (KRd, n = 147; Rd, n = 170). For patients with high-risk cytogenetics, treatment with KRd resulted in a median PFS of 23.1 months, a 9-month improvement relative to treatment with Rd. For patients with standard-risk cytogenetics, treatment with KRd led to a 10-month improvement in median PFS vs Rd. The overall response rates for KRd vs Rd were 79.2% vs 59.6% (high-risk cytogenetics) and 91.2% vs 73.5% (standardrisk cytogenetics); approximately fivefold as many patients with high- or standard-risk cytogenetics achieved a complete response or better with KRd vs Rd (29.2% vs 5.8% and 38.1% vs 6.5%, respectively). KRd improved but did not abrogate the poor prognosis associated with high-risk cytogenetics. This regimen had a favorable benefit-risk profile in patients with relapsed MM, irrespective of cytogenetic risk status, and should be considered a standard of care in these patients. Copyright © 2011 by the American Association for the Advancement of Science; all rights reserved.
Avet-Loiseau H, Fonseca R, Siegel D, Dimopoulos MA, Špička I, Masszi T, Hájek R, Rosiñol L, Goranova-Marinova V, Mihaylov G, et al. Carfilzomib significantly improves the progression-free survival of high-risk patients in multiple myeloma. Blood [Internet]. 2016;128(9):1174 - 1180. WebsiteAbstract
The presence of certain high-risk cytogenetic abnormalities, such as translocations (4;14) and (14;16) and deletion (17p), are known to have a negative impact on survival in multiple myeloma (MM). The phase 3 study ASPIRE (N = 792) demonstrated that progression-free survival (PFS) was significantly improved with carfilzomib, lenalidomide, and dexamethasone (KRd), compared with lenalidomide and dexamethasone (Rd) in relapsed MM. This preplanned subgroup analysis of ASPIRE was conducted to evaluate KRd vs Rd by baseline cytogenetics according to fluorescence in situ hybridization. Of 417 patients with known cytogenetic risk status, 100 patients (24%) were categorized with high-risk cytogenetics (KRd, n548; Rd, n552) and 317 (76%) were categorized with standard-risk cytogenetics (KRd, n = 147; Rd, n = 170). For patients with high-risk cytogenetics, treatment with KRd resulted in a median PFS of 23.1 months, a 9-month improvement relative to treatment with Rd. For patients with standard-risk cytogenetics, treatment with KRd led to a 10-month improvement in median PFS vs Rd. The overall response rates for KRd vs Rd were 79.2% vs 59.6% (high-risk cytogenetics) and 91.2% vs 73.5% (standardrisk cytogenetics); approximately fivefold as many patients with high- or standard-risk cytogenetics achieved a complete response or better with KRd vs Rd (29.2% vs 5.8% and 38.1% vs 6.5%, respectively). KRd improved but did not abrogate the poor prognosis associated with high-risk cytogenetics. This regimen had a favorable benefit-risk profile in patients with relapsed MM, irrespective of cytogenetic risk status, and should be considered a standard of care in these patients. Copyright © 2011 by the American Association for the Advancement of Science; all rights reserved.
Lymberakis P, Valakos ED, Sagonas K, Pafilis P. The castaway: characteristic islet features affect the ecology of the most isolated European lizard. Acta Herpetologica. 2016;11(2):161-169.
Rizos D. Catalog of unified nomenclature and coding of laboratory tests. Archives of Hellenic Medicine [Internet]. 2016;33:420-421. Website
Rizos D, Belesi C, Grouzi E, Manolis I, Stylianakis A, Themeli-Digalaki K, Karakitsos P, Tsioli P, Siorenda A, Vrani V, et al. Catalog of uniform nomenclature and coding of laboratory tests. Archives of Hellenic Medicine. 2016;32(6):777 - 788.Abstract
© Athens Medical Society. In March 2013, the Health Procurement Committee of the Greek Ministry of Health appointed a committee consisting of laboratory scientists to compile a list of laboratory tests performed on biological fluids, cells and tissues. This committee compiled a list entitled Catalog of Uniform Nomenclature and Coding of Laboratory Tests (CUNCLT), using as its basis the list of reagents of the European Diagnostics Manufacturers Association (EDMA). The CUNCLT refers to the nomenclature of the laboratory tests and does not include all the materials (reagents, consumables, solutions, calibrators, controls, equipment, etc.) and software that may be necessary for performing the tests. The CUNCLT categorizes the laboratory tests that are performed on biological fluids, cells and tissues into eight main categories, each including subcategories of the 1st and 2nd levels. The eight main categories of the CUNCLT, namely Clinical Chemistry- Biochemistry, Immunochemistry, Hematology, Microbiology (cultures), Infectious Immunology, Molecular Biology and Genetics, Pathology-Cytology, Immunology, generally correspond to the categories of clinical laboratories that operate in public hospitals. The CUNCLT includes a total of 2,403 tests and according to its creation rationale, it is imperative that this list is regularly updated. CUNCLT is an important effort at the recording and classification of the laboratory tests carried out in clinical laboratories on biological fluids, cells and tissues. This list could be the basis for introducing the coding of laboratory tests in the laboratory information systems of public hospitals, for matching with the codes of laboratory tests prescribed by the National Organization for Health Care Services (EOPYY) and for specifications for the purchase of the reagents for laboratory testing.
Vrachatis DA, Papaioannou TG, Protogerou AD. Central blood pressure measurement. In: Hypertension and Cardiovascular Disease. ; 2016. pp. 49 - 58. Website
Liakou CG, Mastorakos G, Makris K, Fatouros IG, Avloniti A, Marketos H, Antoniou JD, Galanos A, Dontas I, Rizos D, et al. Changes of serum sclerostin and Dickkopf-1 levels during the menstrual cycle. A pilot study. Endocrine [Internet]. 2016;54:543-551. Website
Caers J, de Larrea CF, Leleu X, Heusschen R, Zojer N, Decaux O, Kastritis E, Minnema M, Jurczyszyn A, Beguin Y, et al. The changing landscape of smoldering multiple myeloma: A european perspective. Oncologist [Internet]. 2016;21(3):333 - 342. WebsiteAbstract
Smoldering multiple myeloma (SMM) is an asymptomatic clonal plasma cell disorder and bridges monoclonal gammo- pathyof undetermined significance to multiple myeloma (MM), based on higher levels of circulating monoclonal immunoglobulin and bone marrow plasmocytosis without end-organ damage. Until a Spanish study reported fewer MM-related events and better overall survival among patients with high- risk SMM treated with lenalidomide and dexamethasone, prior studies had failed to show improved survival with earlier intervention,although a reduction in skeletal-related events (without any impact on disease progression) has been described with bisphosphonate use. Risk factors have now been defined, and a subset of ultra-high-risk patients have been reclassified by the International Myeloma Working Group as MM, and thus will require optimal MM treatment, based on biomarkers that identify patients with a >80% risk of progression. The number of these redefined patients is small (~10%), but important to unravel, because theirriskof progression to overt MM is substantial ($80% within 2 years). Patients with a high-risk cytogenetic profile are not yet considered for early treatment, because groups are heterogeneous and risk factors other than cytogenetics are deemed to weight higher. Because patients with ultra-high- risk SMM are now considered as MM and may be treated as such, concerns exist that earlier therapy may increase the risk of selecting resistant clones and induce side effects and costs. Therefore, an even more accurate identification of patients who would benefit from interventions needs to be performed, and clinical judgment and careful discussion of pros and cons of treatment initiation need to be undertaken. For the majority of SMM patients, the standard of care remains observation until development of symptomatic MM occurs, encouraging participation in ongoing and upcoming SMM/early MM clinical trials, as well as consideration of bisphosphonate use in patients with early bone loss. © AlphaMed Press 2016.
Caers J, de Larrea CF, Leleu X, Heusschen R, Zojer N, Decaux O, Kastritis E, Minnema M, Jurczyszyn A, Beguin Y, et al. The changing landscape of smoldering multiple myeloma: A european perspective. Oncologist [Internet]. 2016;21(3):333 - 342. WebsiteAbstract
Smoldering multiple myeloma (SMM) is an asymptomatic clonal plasma cell disorder and bridges monoclonal gammo- pathyof undetermined significance to multiple myeloma (MM), based on higher levels of circulating monoclonal immunoglobulin and bone marrow plasmocytosis without end-organ damage. Until a Spanish study reported fewer MM-related events and better overall survival among patients with high- risk SMM treated with lenalidomide and dexamethasone, prior studies had failed to show improved survival with earlier intervention,although a reduction in skeletal-related events (without any impact on disease progression) has been described with bisphosphonate use. Risk factors have now been defined, and a subset of ultra-high-risk patients have been reclassified by the International Myeloma Working Group as MM, and thus will require optimal MM treatment, based on biomarkers that identify patients with a >80% risk of progression. The number of these redefined patients is small (~10%), but important to unravel, because theirriskof progression to overt MM is substantial ($80% within 2 years). Patients with a high-risk cytogenetic profile are not yet considered for early treatment, because groups are heterogeneous and risk factors other than cytogenetics are deemed to weight higher. Because patients with ultra-high- risk SMM are now considered as MM and may be treated as such, concerns exist that earlier therapy may increase the risk of selecting resistant clones and induce side effects and costs. Therefore, an even more accurate identification of patients who would benefit from interventions needs to be performed, and clinical judgment and careful discussion of pros and cons of treatment initiation need to be undertaken. For the majority of SMM patients, the standard of care remains observation until development of symptomatic MM occurs, encouraging participation in ongoing and upcoming SMM/early MM clinical trials, as well as consideration of bisphosphonate use in patients with early bone loss. © AlphaMed Press 2016.
Marouga A, Dalamaga M, Kastania AN, Kroupis C, Lagiou M, Saounatsou K, Dimas K, Vlahakos DV. Circulating resistin is a significant predictor of mortality independently from cardiovascular comorbidities in elderly, non-diabetic subjects with chronic kidney disease. Biomarkers. 2016;21(1):73-9.Abstract
CONTEXT: Resistin is associated with inflammation, atherosclerosis and cardiovascular (CV) disease. OBJECTIVE: To associate circulating resistin with all-cause and CV mortality in chronic kidney disease (CKD) patients. METHODS: Serum resistin was determined in a cohort of 80 elderly, non-diabetic patients with stable CKD at different stages in a follow-up period of 5 years. RESULTS: Circulating resistin was significantly elevated in deceased compared to alive patients. Resistin emerged as an independent biomarker of all-cause and CV mortality after a 5-year follow-up period. CONCLUSION: Elevated circulating resistin was a significant independent predictor of CV and all-cause mortality in elderly, non-diabetic CKD patients.
Gogou A, Triantaphyllou M, Xoplaki E, Izdebski A, Parinos C, Dimiza M, Bouloubassi I, Luterbacher J, Kouli K, Martrat B, et al. Climate variability and socio-environmental changes in the northern Aegean (NE Mediterranean) during the last 1500 years. Quaternary Science Reviews [Internet]. 2016;136:209-228. Publisher's VersionAbstract
We provide new evidence on sea surface temperature (SST) variations and paleoceanographic/paleoenvironmental changes over the past 1500 years for the north Aegean Sea (NE Mediterranean). The reconstructions are based on multiproxy analyses, obtained from the high resolution (decadal to multi-decadal) marine record M2 retrieved from the Athos basin. Reconstructed SSTs show an increase from ca. 850 to 950 AD and from ca. 1100 to 1300 AD. A cooling phase of almost 1.5 °C is observed from ca. 1600 AD to 1700 AD. This seems to have been the starting point of a continuous SST warming trend until the end of the reconstructed period, interrupted by two prominent cooling events at 1832 ± 15 AD and 1995 ± 1 AD. Application of an adaptive Kernel smoothing suggests that the current warming in the reconstructed SSTs of the north Aegean might be unprecedented in the context of the past 1500 years. Internal variability in atmospheric/oceanic circulations systems as well as external forcing as solar radiation and volcanic activity could have affected temperature variations in the north Aegean Sea over the past 1500 years. The marked temperature drop of approximately ∼2 °C at 1832 ± 15 yr AD could be related to the 1809 ΑD ‘unknown’ and the 1815 AD Tambora volcanic eruptions. Paleoenvironmental proxy-indices of the M2 record show enhanced riverine/continental inputs in the northern Aegean after ca. 1450 AD.The paleoclimatic evidence derived from the M2 record is combined with a socio-environmental study of the history of the north Aegean region. We show that the cultivation of temperature-sensitive crops, i.e. walnut, vine and olive, co-occurred with stable and warmer temperatures, while its end coincided with a significant episode of cooler temperatures. Periods of agricultural growth in Macedonia coincide with periods of warmer and more stable SSTs, but further exploration is required in order to identify the causal links behind the observed phenomena. The Black Death likely caused major changes in agricultural activity in the north Aegean region, as reflected in the pollen data from land sites of Macedonia and the M2 proxy-reconstructions. Finally, we conclude that the early modern peaks in mountain vegetation in the Rhodope and Macedonia highlands, visible also in the M2 record, were very likely climate-driven.
Gogou A, Triantaphyllou M, Xoplaki E, Izdebski A, Parinos C, Dimiza M, Bouloubassi I, Luterbacher J, Kouli K, Martrat B, et al. Climate variability and socio-environmental changes in the northern Aegean (NE Mediterranean) during the last 1500 years. Quaternary Science Reviews [Internet]. 2016;136:209–228. Publisher's VersionAbstract
AbstractWe provide new evidence on sea surface temperature (SST) variations and paleoceanographic/paleoenvironmental changes over the past 1500 years for the north Aegean Sea (NE Mediterranean). The reconstructions are based on multiproxy analyses, obtained from the high resolution (decadal to multi-decadal) marine record M2 retrieved from the Athos basin. Reconstructed SSTs show an increase from ca. 850 to 950 AD and from ca. 1100 to 1300 AD. A cooling phase of almost 1.5 °C is observed from ca. 1600 AD to 1700 AD. This seems to have been the starting point of a continuous SST warming trend until the end of the reconstructed period, interrupted by two prominent cooling events at 1832 ± 15 AD and 1995 ± 1 AD. Application of an adaptive Kernel smoothing suggests that the current warming in the reconstructed SSTs of the north Aegean might be unprecedented in the context of the past 1500 years. Internal variability in atmospheric/oceanic circulations systems as well as external forcing as solar radiation and volcanic activity could have affected temperature variations in the north Aegean Sea over the past 1500 years. The marked temperature drop of approximately ∼2 °C at 1832 ± 15 yr AD could be related to the 1809 ΑD ‘unknown’ and the 1815 AD Tambora volcanic eruptions. Paleoenvironmental proxy-indices of the M2 record show enhanced riverine/continental inputs in the northern Aegean after ca. 1450 AD. The paleoclimatic evidence derived from the M2 record is combined with a socio-environmental study of the history of the north Aegean region. We show that the cultivation of temperature-sensitive crops, i.e. walnut, vine and olive, co-occurred with stable and warmer temperatures, while its end coincided with a significant episode of cooler temperatures. Periods of agricultural growth in Macedonia coincide with periods of warmer and more stable SSTs, but further exploration is required in order to identify the causal links behind the observed phenomena. The Black Death likely caused major changes in agricultural activity in the north Aegean region, as reflected in the pollen data from land sites of Macedonia and the M2 proxy-reconstructions. Finally, we conclude that the early modern peaks in mountain vegetation in the Rhodope and Macedonia highlands, visible also in the M2 record, were very likely climate-driven.
Kotsakiozi P, Parmakelis A, Konstantakis A, Valakos ED. Climatic conditions driving a part of changes in the biochemical composition in land snails: Insights from the endangered Codringtonia (Gastropoda: Pulmonata). Biologia. 2016;71(8):903-916.
Kastritis E, Papassotiriou I, Terpos E, Roussou M, Gavriatopoulou M, Komitopoulou A, Skevaki C, Eleutherakis-Papaiakovou E, Pamboucas C, Psimenou E, et al. Clinical and prognostic significance of serum levels of von Willebrand factor and ADAMTS-13 antigens in AL amyloidosis. Blood [Internet]. 2016;128(3):405 - 409. WebsiteAbstract
Cardiac dysfunction determines prognosis in amyloid light-chain (AL) amyloidosis. The heart is the central organ of the vascular system in which endothelium function is critical for the circulatory homeostasis, but there are limited data on endothelial function in AL amyloidosis. von Willebrand factor (VWF) has been considered as a marker of endothelial activation and dysfunction, whereas a disintegrin and metalloproteinase with thrombospondin type-1 repeats 13 (ADAMTS-13) cleaves VWF multimers, but both have been associated with prognosis in cardiovascular disease. We measured the serum levels of VWF (VWF:Ag) and ADAMTS-13 antigens in 111 newly diagnosed patients with AL amyloidosis. The levels of VWF:Ag were significantly higher than in healthy controls; 76% of patients with AL had VWF:Ag levels higher than the upper levels of controls. There was no significant association of VWF:Ag levels with patterns of organ involvement, free light-chain levels, the levels of cardiac biomarkers, or renal dysfunction but correlated with low systolic blood pressure. VWF:Ag levels ≥230.0 U/dL were associated with higher probability of early death and poor survival independently of cardiac biomarkers and low systolic blood pressure (SBP). Moreover, among patients with Mayo stage III or stage IIIB (that is stage III with N-terminal pro-brain natriuretic peptide [NTproBNP] >8500 pg/mL) disease, VWF:Ag identified subgroups of patients with very poor outcome. Low ADAMTS-13 levels correlated with high levels of NTproBNP but had no independent prognostic significance. In conclusion, high VWF:Ag levels, probably representing endothelial dysfunction, are associated with prognosis in patients with AL amyloidosis, independently of other features of the disease or cardiac biomarkers. © 2016 by The American Society of Hematology.
Kastritis E, Papassotiriou I, Terpos E, Roussou M, Gavriatopoulou M, Komitopoulou A, Skevaki C, Eleutherakis-Papaiakovou E, Pamboucas C, Psimenou E, et al. Clinical and prognostic significance of serum levels of von Willebrand factor and ADAMTS-13 antigens in AL amyloidosis. Blood [Internet]. 2016;128(3):405 - 409. WebsiteAbstract
Cardiac dysfunction determines prognosis in amyloid light-chain (AL) amyloidosis. The heart is the central organ of the vascular system in which endothelium function is critical for the circulatory homeostasis, but there are limited data on endothelial function in AL amyloidosis. von Willebrand factor (VWF) has been considered as a marker of endothelial activation and dysfunction, whereas a disintegrin and metalloproteinase with thrombospondin type-1 repeats 13 (ADAMTS-13) cleaves VWF multimers, but both have been associated with prognosis in cardiovascular disease. We measured the serum levels of VWF (VWF:Ag) and ADAMTS-13 antigens in 111 newly diagnosed patients with AL amyloidosis. The levels of VWF:Ag were significantly higher than in healthy controls; 76% of patients with AL had VWF:Ag levels higher than the upper levels of controls. There was no significant association of VWF:Ag levels with patterns of organ involvement, free light-chain levels, the levels of cardiac biomarkers, or renal dysfunction but correlated with low systolic blood pressure. VWF:Ag levels ≥230.0 U/dL were associated with higher probability of early death and poor survival independently of cardiac biomarkers and low systolic blood pressure (SBP). Moreover, among patients with Mayo stage III or stage IIIB (that is stage III with N-terminal pro-brain natriuretic peptide [NTproBNP] >8500 pg/mL) disease, VWF:Ag identified subgroups of patients with very poor outcome. Low ADAMTS-13 levels correlated with high levels of NTproBNP but had no independent prognostic significance. In conclusion, high VWF:Ag levels, probably representing endothelial dysfunction, are associated with prognosis in patients with AL amyloidosis, independently of other features of the disease or cardiac biomarkers. © 2016 by The American Society of Hematology.
Matsangouras IT, Nastos PT, Kapsomenakis J. Cloud-to-ground lightning activity over Greece: Spatio-temporal analysis and impacts. Atmospheric Research [Internet]. 2016;169:485 - 496. Website
Lantzouraki, D.Z. SZPVJP. Comparison of the Antioxidant and Antiradical Activity of Pomegranate (Punica granatum L.) by Ultrasound-Assisted and Classical Extraction. Analytical Letters [Internet]. 2016;49:969-978. Website
Tzetis M, Konstantinidou A, Sofocleous C, Kosma K, Mitrakos A, Tzannatos C, Kitsiou‐Tzeli S. Compound heterozygosity of a paternal submicroscopic deletion and a maternal missense mutation in POR gene: Antley‐bixler syndrome phenotype in three sibling fetuses. Birth Defects Research Part A: Clinical and Molecular Teratology. 2016;106(7):536-541.
Vrontaki E, Melagraki G, Kaffe E, Mavromoustakos T, Kokotos E, Aidinis V, Afantitis A. Computer Aided Drug Design Approaches for Identification of Novel Autotaxin (ATX) Inhibitors. Current Medicinal Chemistry [Internet]. 2016;23(17):1708 - 1724. Website
Lykiardopoulou E-M, Tsampa K, Mertzimekis TJ. Construction and Ion-Beam Characterization of Nuclear Targets. In: Hellenic Nuclear Physics Society; 2016.
Vavuranakis M, Kalogeras K, Lavda M, Kolokathis M-A, Papaioannou T, Oikonomou E, Stasinopoulou M, Vrachatis D, Moldovan C, Kariori M, et al. Correlation of CoreValve implantation ‘true cover index’ with short and mid-term aortic regurgitation: A novel index. International Journal of Cardiology [Internet]. 2016;223:482 - 487. Website
Kastritis E, Dimopoulos MA. Current therapy guidelines for Waldenstrom's macroglobulinaemia. Best Practice and Research: Clinical Haematology [Internet]. 2016;29(2):194 - 205. WebsiteAbstract
Waldenstrom's macroglobulinaemia (WM) is a B-cell neoplasm in which bone marrow is infiltrated by lymphoplasmacytic cells that secrete monoclonal immunoglobulin M (IgM). More than a decade ago, specific criteria were agreed to define diagnosis and symptomatic disease requiring therapy; however, treatment recommendations change as new options emerge. Treatment decisions consider specific disease characteristics (burden of disease, IgM levels, presence of cytopenias) and patient characteristics (age, comorbidities, toxicity). Recently, the impact of specific mutations (in MYD88 and CXCR4) in response to specific therapies has been reported, and this may affect treatment decisions in the future. Chemo-immunotherapy combinations based on rituximab with cyclophosphamide/dexamethasone, bendamustine or bortezomib/dexamethasone are indicated for most patients. The BTK inhibitor ibrutinib was recently approved for patients with WM, and is a new option for selected newly diagnosed or relapsing patients. New B-cell receptor inhibitors, second-generation proteasome inhibitors and mammalian target of rapamycin inhibitors are promising; however, more data are needed from high-quality clinical trials. © 2016 Elsevier Ltd
Kastritis E, Dimopoulos MA. Current therapy guidelines for Waldenstrom's macroglobulinaemia. Best Practice and Research: Clinical Haematology [Internet]. 2016;29(2):194 - 205. WebsiteAbstract
Waldenstrom's macroglobulinaemia (WM) is a B-cell neoplasm in which bone marrow is infiltrated by lymphoplasmacytic cells that secrete monoclonal immunoglobulin M (IgM). More than a decade ago, specific criteria were agreed to define diagnosis and symptomatic disease requiring therapy; however, treatment recommendations change as new options emerge. Treatment decisions consider specific disease characteristics (burden of disease, IgM levels, presence of cytopenias) and patient characteristics (age, comorbidities, toxicity). Recently, the impact of specific mutations (in MYD88 and CXCR4) in response to specific therapies has been reported, and this may affect treatment decisions in the future. Chemo-immunotherapy combinations based on rituximab with cyclophosphamide/dexamethasone, bendamustine or bortezomib/dexamethasone are indicated for most patients. The BTK inhibitor ibrutinib was recently approved for patients with WM, and is a new option for selected newly diagnosed or relapsing patients. New B-cell receptor inhibitors, second-generation proteasome inhibitors and mammalian target of rapamycin inhibitors are promising; however, more data are needed from high-quality clinical trials. © 2016 Elsevier Ltd
Gavriatopoulou M, Terpos E, Kastritis E, Dimopoulos MA. Current treatments for renal failure due to multiple myeloma. Expert Opinion on Pharmacotherapy [Internet]. 2016;17(16):2165 - 2177. WebsiteAbstract
Introduction: Renal impairment (RI) is one of the most common complication of multiple myeloma (MM). RI is present in almost 20% of MM patients at diagnosis and in 40%-50% of patients during the course of their disease. Areas covered: Biology along with tools for diagnosis and management of RI are reported in this paper. Papers published in PubMed and reported abstracts up to May 2016 were used. Expert opinion: Moderate and severe RI increases the risk of early death; thus rapid intervention and initiation of anti-myeloma treatment is essential and improves renal outcomes in RI patients. Bortezomib and dexamethasone triplet combinations are the current standard of therapy for MM patients with acute kidney injury due to cast nephropathy; they offer high rates of both anti-myeloma response and renal recovery. Thalidomide and lenalidomide may be used in bortezomib refractory patients. In the relapsed/refractory setting additional treatment options such as carfilzomib, pomalidomide and monoclonal antibodies are available; however, there is limited data for their effects on patients with RI. High dose melphalan with autologous stem cell transplantation should be considered in otherwise eligible patients with RI. Finally, high cut-off hemodialysis membranes do not seem to offer significant additive effects on anti-myeloma therapies. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
Gavriatopoulou M, Terpos E, Kastritis E, Dimopoulos MA. Current treatments for renal failure due to multiple myeloma. Expert Opinion on Pharmacotherapy [Internet]. 2016;17(16):2165 - 2177. WebsiteAbstract
Introduction: Renal impairment (RI) is one of the most common complication of multiple myeloma (MM). RI is present in almost 20% of MM patients at diagnosis and in 40%-50% of patients during the course of their disease. Areas covered: Biology along with tools for diagnosis and management of RI are reported in this paper. Papers published in PubMed and reported abstracts up to May 2016 were used. Expert opinion: Moderate and severe RI increases the risk of early death; thus rapid intervention and initiation of anti-myeloma treatment is essential and improves renal outcomes in RI patients. Bortezomib and dexamethasone triplet combinations are the current standard of therapy for MM patients with acute kidney injury due to cast nephropathy; they offer high rates of both anti-myeloma response and renal recovery. Thalidomide and lenalidomide may be used in bortezomib refractory patients. In the relapsed/refractory setting additional treatment options such as carfilzomib, pomalidomide and monoclonal antibodies are available; however, there is limited data for their effects on patients with RI. High dose melphalan with autologous stem cell transplantation should be considered in otherwise eligible patients with RI. Finally, high cut-off hemodialysis membranes do not seem to offer significant additive effects on anti-myeloma therapies. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
Dimitrakopoulos Y, Burnetas AN. Customer equilibrium and optimal strategies in an M/M/1 queue with dynamic service control. European Journal of Operational Research [Internet]. 2016;252:477-486. WebsiteAbstract
We consider the problem of customer equilibrium strategies in an M/M/1 queue under dynamic service control. The service rate switches between a low and a high value depending on system congestion. Arriving customers do not observe the system state at the moment of arrival. We show that due to service rate variation, the customer equilibrium strategy is not generally unique, and derive an upper bound on the number of possible equilibria. For the problem of social welfare optimization, we numerically analyze the relationship between the optimal and equilibrium arrival rates as a function of various parameter values, and assess the level of inefficiency via the price of anarchy measure. We finally derive analytic solutions for the special case where the service rate switch occurs when the queue ceases to be empty. © 2016 Elsevier B.V. All rights reserved.
Sergentanis TN, Kastritis E, Terpos E, Dimopoulos MA, Psaltopoulou T. Cytogenetics and Survival of Multiple Myeloma: Isolated and Combined Effects. Clinical Lymphoma, Myeloma and Leukemia [Internet]. 2016;16(6):335 - 340. WebsiteAbstract
Background A variety of clinical and laboratory prognostic factors for multiple myeloma (MM) have been addressed in published studies. The prognostic significance of cytogenetic abnormalities is also under investigation. Patients and Methods The present study evaluated the potential prognostic role of cytogenetic events and their combinations in terms of overall survival in a large cohort of unselected patients with MM (n = 432). Multivariate Cox regression analysis was performed, adjusting for age, gender, Chronic Kidney Disease Epidemiology Collaboration Kidney Disease: Improving Global Outcomes classification, International Staging System score, Eastern Cooperative Oncology Group performance status, serum lactate dehydrogenase, serum calcium, platelet count, and blood hemoglobin. Results The presence of del(13q) (adjusted hazard ratio [HR], 1.71; 95% confidence interval [CI], 1.18-2.47), t(4;14) (adjusted HR, 2.00; 95% CI, 1.19-3.35), and/or del(17p) (adjusted HR, 2.03; 95% CI, 1.22-3.37) was independently associated with poorer overall survival. The poor prognosis seemed more pronounced among patients harboring combinations of 2 adverse cytogenetic abnormalities. In contrast, t(14;16), t(11;14), and add(1q21) were not associated with overall survival. The effect of bortezomib seemed rather minimal in the modification of the prognostic role mediated by del(17p). Conclusion The presence of del(13q), t(4;14), and del(17p), singly or in combination, seems to be an independent poor prognostic factor for patients with MM. © 2016 Elsevier Inc.
Sergentanis TN, Kastritis E, Terpos E, Dimopoulos MA, Psaltopoulou T. Cytogenetics and Survival of Multiple Myeloma: Isolated and Combined Effects. Clinical Lymphoma, Myeloma and Leukemia [Internet]. 2016;16(6):335 - 340. WebsiteAbstract
Background A variety of clinical and laboratory prognostic factors for multiple myeloma (MM) have been addressed in published studies. The prognostic significance of cytogenetic abnormalities is also under investigation. Patients and Methods The present study evaluated the potential prognostic role of cytogenetic events and their combinations in terms of overall survival in a large cohort of unselected patients with MM (n = 432). Multivariate Cox regression analysis was performed, adjusting for age, gender, Chronic Kidney Disease Epidemiology Collaboration Kidney Disease: Improving Global Outcomes classification, International Staging System score, Eastern Cooperative Oncology Group performance status, serum lactate dehydrogenase, serum calcium, platelet count, and blood hemoglobin. Results The presence of del(13q) (adjusted hazard ratio [HR], 1.71; 95% confidence interval [CI], 1.18-2.47), t(4;14) (adjusted HR, 2.00; 95% CI, 1.19-3.35), and/or del(17p) (adjusted HR, 2.03; 95% CI, 1.22-3.37) was independently associated with poorer overall survival. The poor prognosis seemed more pronounced among patients harboring combinations of 2 adverse cytogenetic abnormalities. In contrast, t(14;16), t(11;14), and add(1q21) were not associated with overall survival. The effect of bortezomib seemed rather minimal in the modification of the prognostic role mediated by del(17p). Conclusion The presence of del(13q), t(4;14), and del(17p), singly or in combination, seems to be an independent poor prognostic factor for patients with MM. © 2016 Elsevier Inc.
Samara P, Skopeliti M, Tsiatas ML, Georgaki S, Gouloumis C, Voelter W, Dimopoulos A-M, Bamias A, Tsitsilonis OE. A Cytokine cocktail augments the efficacy of adoptive NK-92 cell therapy against mouse xenografts of human cancer. Anticancer Research [Internet]. 2016;36(7):3373 - 3382. WebsiteAbstract
Background/Aim: Peripheral blood mononuclear cells (PBMCs) activated with immobilized monoclonal antibody against cluster of differentiation 3 (CD3) secrete cytokines in their culture supernatant (termed ACD3S). We examined the antitumor efficacy of ACD3S-activated NK-92 cells in vitro and in vivo. Materials and Methods: Interleukin (IL) 2-depleted NK-92 cells were reactivated with ACD3S, analyzed for their phenotype and tested for cytotoxicity, and perforin and interferon (IFN) production. Severe combined immunodeficient (SCID) mice xenografted with human melanoma and breast cancer cells were treated with ACD3S-activated NK-92 cells and tumor growth was monitored. Results: Brief activation of IL2-depleted NK-92 cells with ACD3S fully restored their in vitro cytotoxicity towards tumor cells. ACD3S-activated NK-92 cells were phenotypically similar to standard NK-92 cells, but exhibited prolonged cytotoxicity and produced higher levels of IFN. When adoptively transferred to tumor-bearing SCID mice, these cells retarded the growth of melanoma and breast tumors. Conclusion: Stimulation of NK-92 cells with ACD3S may be useful in clinical cancer therapy, as an alternative method for ex vivo natural killer cell activation.
Dimopoulos MA, Oriol A, Nahi H, San-Miguel J, Bahlis NJ, Usmani SZ, Rabin N, Orlowski RZ, Komarnicki M, Suzuki K, et al. Daratumumab, lenalidomide, and dexamethasone for multiple myeloma. New England Journal of Medicine [Internet]. 2016;375(14):1319 - 1331. WebsiteAbstract
BACKGROUND: Daratumumab showed promising efficacy alone and with lenalidomide and dexamethasone in a phase 1-2 study involving patients with relapsed or refractory multiple myeloma. METHODS: In this phase 3 trial, we randomly assigned 569 patients with multiple myeloma who had received one or more previous lines of therapy to receive lenalidomide and dexamethasone either alone (control group) or in combination with daratumumab (daratumumab group). The primary end point was progression-free survival. RESULTS: At a median follow-up of 13.5 months in a protocol-specified interim analysis, 169 events of disease progression or death were observed (in 53 of 286 patients [18.5%] in the daratumumab group vs. 116 of 283 [41.0%] in the control group; hazard ratio, 0.37; 95% confidence interval [CI], 0.27 to 0.52; P<0.001 by stratified log-rank test). The Kaplan- Meier rate of progression-free survival at 12 months was 83.2% (95% CI, 78.3 to 87.2) in the daratumumab group, as compared with 60.1% (95% CI, 54.0 to 65.7) in the control group. A significantly higher rate of overall response was observed in the daratumumab group than in the control group (92.9% vs. 76.4%, P<0.001), as was a higher rate of complete response or better (43.1% vs. 19.2%, P<0.001). In the daratumumab group, 22.4% of the patients had results below the threshold for minimal residual disease (1 tumor cell per 105 white cells), as compared with 4.6% of those in the control group (P<0.001); results below the threshold for minimal residual disease were associated with improved outcomes. The most common adverse events of grade 3 or 4 during treatment were neutropenia (in 51.9% of the patients in the daratumumab group vs. 37.0% of those in the control group), thrombocytopenia (in 12.7% vs. 13.5%), and anemia (in 12.4% vs. 19.6%). Daratumumab-associated infusion-related reactions occurred in 47.7% of the patients and were mostly of grade 1 or 2. CONCLUSIONS: The addition of daratumumab to lenalidomide and dexamethasone significantly lengthened progression-free survival among patients with relapsed or refractory multiple myeloma. Daratumumab was associated with infusion-related reactions and a higher rate of neutropenia than the control therapy. Copyright © 2016 Massachusetts Medical Society. All rights reserved.
Dimopoulos MA, Oriol A, Nahi H, San-Miguel J, Bahlis NJ, Usmani SZ, Rabin N, Orlowski RZ, Komarnicki M, Suzuki K, et al. Daratumumab, lenalidomide, and dexamethasone for multiple myeloma. New England Journal of Medicine [Internet]. 2016;375(14):1319 - 1331. WebsiteAbstract
BACKGROUND: Daratumumab showed promising efficacy alone and with lenalidomide and dexamethasone in a phase 1-2 study involving patients with relapsed or refractory multiple myeloma. METHODS: In this phase 3 trial, we randomly assigned 569 patients with multiple myeloma who had received one or more previous lines of therapy to receive lenalidomide and dexamethasone either alone (control group) or in combination with daratumumab (daratumumab group). The primary end point was progression-free survival. RESULTS: At a median follow-up of 13.5 months in a protocol-specified interim analysis, 169 events of disease progression or death were observed (in 53 of 286 patients [18.5%] in the daratumumab group vs. 116 of 283 [41.0%] in the control group; hazard ratio, 0.37; 95% confidence interval [CI], 0.27 to 0.52; P<0.001 by stratified log-rank test). The Kaplan- Meier rate of progression-free survival at 12 months was 83.2% (95% CI, 78.3 to 87.2) in the daratumumab group, as compared with 60.1% (95% CI, 54.0 to 65.7) in the control group. A significantly higher rate of overall response was observed in the daratumumab group than in the control group (92.9% vs. 76.4%, P<0.001), as was a higher rate of complete response or better (43.1% vs. 19.2%, P<0.001). In the daratumumab group, 22.4% of the patients had results below the threshold for minimal residual disease (1 tumor cell per 105 white cells), as compared with 4.6% of those in the control group (P<0.001); results below the threshold for minimal residual disease were associated with improved outcomes. The most common adverse events of grade 3 or 4 during treatment were neutropenia (in 51.9% of the patients in the daratumumab group vs. 37.0% of those in the control group), thrombocytopenia (in 12.7% vs. 13.5%), and anemia (in 12.4% vs. 19.6%). Daratumumab-associated infusion-related reactions occurred in 47.7% of the patients and were mostly of grade 1 or 2. CONCLUSIONS: The addition of daratumumab to lenalidomide and dexamethasone significantly lengthened progression-free survival among patients with relapsed or refractory multiple myeloma. Daratumumab was associated with infusion-related reactions and a higher rate of neutropenia than the control therapy. Copyright © 2016 Massachusetts Medical Society. All rights reserved.
Kontogianni VG, Tsoumani ME, Kellici TF, Mavromoustakos T, Gerothanassis IP, Tselepis AD, Tzakos AG. Deconvoluting the dual antiplatelet activity of a plant extract. Journal of Agricultural and Food Chemistry [Internet]. 2016;64(22):4511 - 4521. Website
Lougiakis N, Gavriil E-S, Kairis M, Sioupouli G, Lambrinidis G, Benaki D, Krypotou E, Mikros E, Marakos P, Pouli N, et al. Design and synthesis of purine analogues as highly specific ligands for FcyB, a ubiquitous fungal nucleobase transporter. Bioorg Med Chem. 2016.Abstract
In the course of our study on fungal purine transporters, a number of new 3-deazapurine analogues have been rationally designed, based on the interaction of purine substrates with the Aspergillus nidulans FcyB carrier, and synthesized following an effective synthetic procedure. Certain derivatives have been found to specifically inhibit FcyB-mediated [(3)H]-adenine uptake. Molecular simulations have been performed, suggesting that all active compounds interact with FcyB through the formation of hydrogen bonds with Asn163, while the insertion of hydrophobic fragments at position 9 and N6 of 3-deazaadenine enhanced the inhibition.
Mertzimekis TJ. Development of a dedicated online database for nuclear moments data. INDC(NDS)-0704. 2016.
Vasilakaki S, Barbayianni E, Leonis G, Papadopoulos MG, Mavromoustakos T, Gelb MH, Kokotos G. Development of a potent 2-oxoamide inhibitor of secreted phospholipase A2 guided by molecular docking calculations and molecular dynamics simulations. Bioorganic and Medicinal Chemistry [Internet]. 2016;24(8):1683 - 1695. Website
Hloupis G, Leoussis C, Pagounis V, Tsakiri M, Vassilakis E, Zacharis V. Development of a Wireless Sensor Network System as basis for Early Warning in Slope Monitoring of the Corinth Canal. In: 3rd Joint International Symposium on Deformation Monitoring (JISDM). Vienna; 2016. pdfAbstract
Corinth Canal is an important technical construction with a significant role in marine and land transportation for Greece. Whilst the main highway of the Corinth bridge is well monitored there is no similar monitoring scheme for landslide failures of the canal walls. This work presents an in-house developed real-time early warning landslide triggering system using wireless sensor network (WSN) nodes. Specifically, for the detection of different types of landslide processes (drift, slide and fall) a set of corresponding MEMS (Micro-Electro-Mechanical Systems) sensors (accelerometer, inclinometer, magnetometer) will be used. These sensors along with radio transmission unit and microprocessor comprise a WSN node. The option for in-situ processing (i.e transmitting only alerts) is possible in order to decrease the communication costs. In conjunction with the proposed WSN system, high accuracy geodetic techniques are used with terrestrial laser scanning (TLS) measurements. TLS is augmenting the point-based system to a spatial -based monitoring system. The paper describes the use of WSN node as triggering device in order to alert the users to begin TLS measurements. A description of the network topology is given along with the implementation of the system in selected control points on the canal walls. Real results are shown and the performance of the system is discussed.
Trachana S-P, Pilalis E, Gavalas NG, Tzannis K, Papadodima O, Liontos M, Rodolakis A, Vlachos G, Thomakos N, Haidopoulos D, et al. The development of an angiogenic protein "signature" in ovarian cancer ascites as a tool for biologic and prognostic profiling. PLoS ONE [Internet]. 2016;11(6). WebsiteAbstract
Advanced ovarian cancer (AOC) is one of the leading lethal gynecological cancers in developed countries. Based on the important role of angiogenesis in ovarian cancer oncogenesis and expansion, we hypothesized that the development of an "angiogenic signature" might be helpful in prediction of prognosis and efficacy of anti-angiogenic therapies in this disease. Sixty-nine samples of ascitic fluid- 35 from platinum sensitive and 34 from platinum resistant patients managed with cytoreductive surgery and 1st-line carboplatin-based chemotherapy- were analyzed using the Proteome Profiler™ Human Angiogenesis Array Kit, screening for the presence of 55 soluble angiogenesis-related factors. A protein profile based on the expression of a subset of 25 factors could accurately separate resistant from sensitive patients with a success rate of approximately 90%. The protein profile corresponding to the "sensitive" subset was associated with significantly longer PFS (8 [95% Confidence Interval {CI}: 8-9] vs. 20 months [95% CI: 15-28]; Hazard ratio {HR}: 8.3, p<0.001) and OS (20.5 months [95% CI: 13.5-30] vs. 74 months [95% CI: 36-not reached]; HR: 5.6 [95% CI: 2.8-11.2]; p<0.001). This prognostic performance was superior to that of stage, histology and residual disease after cytoreductive surgery and the levels of vascular endothelial growth factor (VEGF) in ascites. In conclusion, we developed an "angiogenic signature" for patients with AOC, which can be used, after appropriate validation, as a prognostic marker and a tool for selection for anti-angiogenic therapies. © 2016 Trachana et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Trachana S-P, Pilalis E, Gavalas NG, Tzannis K, Papadodima O, Liontos M, Rodolakis A, Vlachos G, Thomakos N, Haidopoulos D, et al. The development of an angiogenic protein "signature" in ovarian cancer ascites as a tool for biologic and prognostic profiling. PLoS ONE [Internet]. 2016;11(6). WebsiteAbstract
Advanced ovarian cancer (AOC) is one of the leading lethal gynecological cancers in developed countries. Based on the important role of angiogenesis in ovarian cancer oncogenesis and expansion, we hypothesized that the development of an "angiogenic signature" might be helpful in prediction of prognosis and efficacy of anti-angiogenic therapies in this disease. Sixty-nine samples of ascitic fluid- 35 from platinum sensitive and 34 from platinum resistant patients managed with cytoreductive surgery and 1st-line carboplatin-based chemotherapy- were analyzed using the Proteome Profiler™ Human Angiogenesis Array Kit, screening for the presence of 55 soluble angiogenesis-related factors. A protein profile based on the expression of a subset of 25 factors could accurately separate resistant from sensitive patients with a success rate of approximately 90%. The protein profile corresponding to the "sensitive" subset was associated with significantly longer PFS (8 [95% Confidence Interval {CI}: 8-9] vs. 20 months [95% CI: 15-28]; Hazard ratio {HR}: 8.3, p<0.001) and OS (20.5 months [95% CI: 13.5-30] vs. 74 months [95% CI: 36-not reached]; HR: 5.6 [95% CI: 2.8-11.2]; p<0.001). This prognostic performance was superior to that of stage, histology and residual disease after cytoreductive surgery and the levels of vascular endothelial growth factor (VEGF) in ascites. In conclusion, we developed an "angiogenic signature" for patients with AOC, which can be used, after appropriate validation, as a prognostic marker and a tool for selection for anti-angiogenic therapies. © 2016 Trachana et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Papaioannou TG, Vlachopoulos C, Tousoulis D. Disassociation of aortic pulse wave velocity and augmentation index in patients with metabolic syndrome: should we blame inflammation?. Blood Pressure [Internet]. 2016;25(3):196 - 197. Website
Diallinas G. Dissection of Transporter Function: From Genetics to Structure. Trends Genet. 2016.Abstract
Transporters are transmembrane proteins mediating the selective uptake or efflux of solutes, metabolites, drugs, or ions across cellular membranes. Despite their immense biological importance in cell nutrition, communication, signaling, and homeostasis, their study remains technically difficult mostly due to their lipid-embedded nature. The study of eukaryotic transporters presents additional complexity due to multiple subcellular control mechanisms that operate to ensure proper membrane traffic, membrane localization, and turnover. Model fungi present unique genetic tools to study eukaryotic transporter function. This review highlights how fungal transporter genetics combined with new methodologies for assaying their cellular expression and function as well as recent structural approaches have led to the functional dissection of selected transporter paradigms in Aspergillus nidulans.
Arabatzis T.
The Structure of Scientific Revolutions and History and Philosophy of Science in Historical Perspective.
In: A. Blum, K. Gavroglu, C. Joas, and J. Renn (eds.), Shifting Paradigms: Thomas S. Kuhn and the History of Science. Berlin: Edition Open Access, Max Planck Institute for the History of Science; 2016. pp. 191-201. 2016a.pdf
Nega AD, Pefkianakis EK, Vougioukalakis GC, Glynos E, Sakellariou G.
Synthesis of P3HT-b-PS donor-acceptor diblock copolymer carrying pendant fullerenes at precise positions along the PS block.
 
. European Polymer Journal [Internet]. 2016;83:148-160.
We present a strategy for the synthesis of a well-defined rod-coil block copolymers of regioregular poly(3hexylthiophene) and polystyrene (P3HT-b-PS), carrying pendant fullerenes (C60) at precise positions along the PS block. The synthesis is achieved by combining ‘living’ anionic polymerization, Kumada catalyst-transfer polycondensation, and click chemistry. Azide terminated polystyrene was synthesized via anionic polymerization, while C60 moieties were grafted along the coil block with a [4+2] Diels-Alder cycloaddition reaction. The regioregular poly(3-hexylthiophene) rod donor block was end-capped with alkyne and was coupled with the azide terminated polystyrene via a copper catalyzed alkyne-azide cycloaddition. Size exclusion chromatography (SEC), NMR, and FTIR spectroscopies were employed to confirm the synthesis of the diblock copolymers. Furthermore, the end-capping of the ‘living’ polystyrene (PS) with the diphenylethylene cyclobutene (DPE-CB) end-group was confirmed by matrixassisted laser desorption/ionization time-of-flight mass spectroscopy (MALDI-TOF MS). Thermogravimetric analysis (TGA) was employed for the estimation of the C60 content in the block copolymer. The C60 content at the coil block was 22 wt% and a strong quenching of photoluminescence (PL) was observed as the result of the aggregation and percolation structure of the C60 within the PS phase. This behavior indicates that the bonding of C60 across the PS block may offer new routes to engineering stable morphologies, where the degree of aggregation/crystallization of the acceptor material is of paramount importance for stable and efficient electron transport.
Κουκουνάρας- Λιάγκης Μάριος.
Teaching Religious Education in Schools and Adolescents’ Social and Emotional Development. An Action Research on the Role of Religious Education and School Community in Adolescents’ Lives
. Cultural and Religious Studies. 2016;4(2):121-133. teaching_religious_education_in_schools.pdf
Liontos M, Anastasiou I, Bamias A, Dimopoulos M-A. DNA damage, tumor mutational load and their impact on immune responses against cancer. Annals of Translational Medicine [Internet]. 2016;4(14). WebsiteAbstract
Advances in immunotherapy have changed the therapeutic landscape in many malignancies. Immune checkpoint inhibitors have already received regulatory approval in melanomas, lung, renal and bladder carcinomas. A common feature of these neoplasms is the increased mutational load, related to a possible increase number of tumor neoantigens that are recognized by the immune system. The mechanisms that DNA damage could confer to the mutational load and the formation of neoantigens and how this could be exploited to advance our immunotherapeutic strategies is discussed in this review. © Annals of Translational Medicine.
Liontos M, Anastasiou I, Bamias A, Dimopoulos M-A. DNA damage, tumor mutational load and their impact on immune responses against cancer. Annals of Translational Medicine [Internet]. 2016;4(14). WebsiteAbstract
Advances in immunotherapy have changed the therapeutic landscape in many malignancies. Immune checkpoint inhibitors have already received regulatory approval in melanomas, lung, renal and bladder carcinomas. A common feature of these neoplasms is the increased mutational load, related to a possible increase number of tumor neoantigens that are recognized by the immune system. The mechanisms that DNA damage could confer to the mutational load and the formation of neoantigens and how this could be exploited to advance our immunotherapeutic strategies is discussed in this review. © Annals of Translational Medicine.
Gkotzamanidou M, Terpos E, Bamia C, Munshi NC, Dimopoulos MA, Souliotis VL. DNA repair of myeloma plasma cells correlates with clinical outcome: The effect of the nonhomologous end-joining inhibitor SCR7. Blood [Internet]. 2016;128(9):1214 - 1225. WebsiteAbstract
DNA repair activity of malignant cells seems to influence therapeutic outcome and patients' survival. Herein, we investigated the mechanistic basis for the link between DNA repair efficiency and response to antimyeloma therapy. Nucleotide excision repair (NER), interstrand cross-links repair (ICL/R), double-strand breaks repair (DSB/R), and chromatin structure were evaluated in multiple myeloma (MM) cell lines (melphalan-sensitive RPMI8226; melphalan-resistant LR5) and bone marrow plasma cells (BMPCs) from MM patients who responded (n = 17) or did not respond (n = 9) to subsequent melphalan therapy. The effect of DSB/R inhibition was also evaluated. Responders' BMPCs showed slower rates of NER and DSB/R (P < .0022), similar rates of ICL/R, and more condensed chromatin structure compared with nonresponders. Moreover, apoptosis rates of BMPCs were inversely correlated with individual DNA repair efficiency and were higher in responders' cells compared with those of nonresponders (P = .0011). Similarly, RPMI8226 cells showed slower rates of NER and DSB/R, comparable rates of ICL/R, more condensed chromatin structure, and higher sensitivity than LR5 cells. Interestingly, cotreatment of BMPCs or cell lines with DSB/R inhibitors significantly reduced the rates ofDSB/R and increasedmelphalan sensitivity of the cells, with the nonhomologous end-joining inhibitor SCR7 showing the strongest effect. Together, responders' BMPCs are characterized by lower efficiencies of NER and DSB/R mechanisms, resulting in higher accumulation of the extremely cytotoxic ICLs andDSBs lesions,which in turn triggers the induction of the apoptotic pathway. Moreover, the enhancement of melphalan cytotoxicity by DSB/R inhibition offers a promising strategy toward improvement of existing antimyeloma regimens. © 2016 by The American Society of Hematology.
Gkotzamanidou M, Terpos E, Bamia C, Munshi NC, Dimopoulos MA, Souliotis VL. DNA repair of myeloma plasma cells correlates with clinical outcome: The effect of the nonhomologous end-joining inhibitor SCR7. Blood [Internet]. 2016;128(9):1214 - 1225. WebsiteAbstract
DNA repair activity of malignant cells seems to influence therapeutic outcome and patients' survival. Herein, we investigated the mechanistic basis for the link between DNA repair efficiency and response to antimyeloma therapy. Nucleotide excision repair (NER), interstrand cross-links repair (ICL/R), double-strand breaks repair (DSB/R), and chromatin structure were evaluated in multiple myeloma (MM) cell lines (melphalan-sensitive RPMI8226; melphalan-resistant LR5) and bone marrow plasma cells (BMPCs) from MM patients who responded (n = 17) or did not respond (n = 9) to subsequent melphalan therapy. The effect of DSB/R inhibition was also evaluated. Responders' BMPCs showed slower rates of NER and DSB/R (P < .0022), similar rates of ICL/R, and more condensed chromatin structure compared with nonresponders. Moreover, apoptosis rates of BMPCs were inversely correlated with individual DNA repair efficiency and were higher in responders' cells compared with those of nonresponders (P = .0011). Similarly, RPMI8226 cells showed slower rates of NER and DSB/R, comparable rates of ICL/R, more condensed chromatin structure, and higher sensitivity than LR5 cells. Interestingly, cotreatment of BMPCs or cell lines with DSB/R inhibitors significantly reduced the rates ofDSB/R and increasedmelphalan sensitivity of the cells, with the nonhomologous end-joining inhibitor SCR7 showing the strongest effect. Together, responders' BMPCs are characterized by lower efficiencies of NER and DSB/R mechanisms, resulting in higher accumulation of the extremely cytotoxic ICLs andDSBs lesions,which in turn triggers the induction of the apoptotic pathway. Moreover, the enhancement of melphalan cytotoxicity by DSB/R inhibition offers a promising strategy toward improvement of existing antimyeloma regimens. © 2016 by The American Society of Hematology.
Vavuranakis M, Siasos G, Zografos T, Oikonomou E, Vrachatis D, Kalogeras K, Papaioannou T, Kolokathis M-A, Moldovan C, Tousoulis D. Dual or single antiplatelet therapy after transcatheter aortic valve implantation? A systematic review and meta-analysis. Current Pharmaceutical Design [Internet]. 2016;22(29):4596 - 4603. Website
Papanikolaou N, Almpanis E, Gantzounis G, Christofi A, Athanasekos L, Stefanou N. Dual photonic-phononic nanocavities for tailoring the acousto-optic interaction. Microelecronic Engineering. 2016;159:80-83.Abstract
We report on the influence of elastic waves on the optical response and light emission in simultaneously photonic and phononic resonant cavities. Elastic waves couple with light through the acousto-optic interaction. Concurrent control of both light and sound through simultaneously photonic–phononic, often called phoxonic, band-gap structures is intended to advance both our understanding as well as our ability to manipulate light with sound and vise versa. In particular, co-localization of light and sound in phoxonic cavities could trigger nonlinear absorption and emission processes and lead to enhanced acousto-optic effects. We review our recent work on sound-controlled optical response and light emission in phoxonic cavities and investigate the limits of validity of the photoelastic model that describes light–sound interaction to first-order approximation. Moreover we present some preliminary results on silicon nitride nanobeam phoxonic devices.
Siasos G, Mourouzis K, Oikonomou E, Vavuranakis M, Vogiatzi G, Briasoulis A, Papageorgiou N, Papaioannou TG, Zografos T, Papapanagiotou A, et al. Duration of dual antiplatelet therapy after coronary stenting. Current Pharmaceutical Design [Internet]. 2016;22(29):4583 - 4595. Website
Kellici TF, Ntountaniotis D, Liapakis G, Tzakos AG, Mavromoustakos T. The dynamic properties of angiotensin II type 1 receptor inverse agonists in solution and in the receptor site. Arabian Journal of Chemistry [Internet]. 2016. Website
Johnson KJ, Glynos E, Sakellariou G, Green P. Dynamics of Star-Shaped Polystyrene Molecules: From Arm Retraction to Cooperativity. Macromolecules [Internet]. 2016;49(15):5669-5676. Publisher's VersionAbstract
The frequency ω dependent storage G′(ω) and loss G″(ω) moduli of star-shaped polystyrene (SPS) molecules of a range of functionalities f and molecular weights per arm Ma were measured under small amplitude oscillatory shear conditions. Star-shaped macromolecules are composed of an inner region, core, where the chain segments are stretched and the “packing” density is higher than that of the outer region, corona. The frequency dependencies of G′(ω) and G″(ω) for low functionality molecules (f<8) with long arms Ma are well described by the model of Milner and McLeish, indicating that the translational dynamics are facilitated by an arm retraction mechanism. With increasing values of f and decreasing Ma the model failsthe arm retraction process is no longer validdue largely to the increasing size of the core in relation to the overall size of the molecule. The molecules exhibit evidence of spatial structural order due to entropic, intermolecular interactions, and the translational dynamics of these molecules occur via a cooperative process, akin to that of soft colloids, for sufficiently large values of f and small Ma. The overall dynamics may be summarized in a diagram delineating different mechanisms that facilitate flow as a function of f and Ma. 
van der Geer, A.A.E., van den Bergh, G.D., Lyras, G.A., Prasetyo, U.W., Awe Due, R., Setiyabudi, E., Drinia, H. The effect of area and isolation on insular dwarf proboscideans. Journal of Biogeography [Internet]. 2016. Publisher's Version
Pagida MA, Konstantinidou AE, Korelidou A, Katsika D, Tsekoura E, Patsouris E, Panayotacopoulou MT. The effect of perinatal hypoxic/ischemic injury on tyrosine hydroxylase expression in the locus coeruleus of the human neonate. Developmental neuroscience. 2016;38(1):41-53.
Stefi AL, Margaritis LH, Christodoulakis NS. The effect of the non ionizing radiation on cultivated plants of Arabidopsis thaliana (Col.). Flora: Morphology, Distribution, Functional Ecology of Plants [Internet]. 2016;223:114 - 120. WebsiteAbstract
A series of experiments was carried out to investigate any structural or biochemical alterations on Arabidopsis thaliana (Col.) plants after a long term exposure to non ionizing radiation emitted from the base unit of a cordless DECT system. Exposed plants, compared to their control counterparts, seem to be affected concerning their biomass and leaf structure. Their leaves are thinner and possess fewer chloroplasts. SEM observations of the exposed leaves reveal that the only feature affected is the pubescence which almost disappears while TEM investigation revealed minor structural effects in the chloroplasts. The reduction in the number of chloroplasts as well as the decrease of stroma thylakoids and photosynthetic pigments are probably the main reasons for a weak photosynthetic potential and a consequent reduction of the biomass production. © 2016 Elsevier GmbH.
Dedes A, Karamitros D, Spanos VC. {Effective Theory for Electroweak Doublet Dark Matter}. Phys. Rev. 2016;D94:095008.
Ververis C, Christodoulakis NS, Santas R, Santas P, Georghiou K. Effects of municipal sludge and treated waste water on biomass yield and fiber properties of kenaf (Hibiscus cannabinus L.). Industrial Crops and Products [Internet]. 2016;84:7 - 12. WebsiteAbstract
Kenaf (Hibiscus cannabinus L.) was experimentally cultivated with the use of digested, dried sewage sludge (130 t/ha) and water from a municipal Sewage Treatment Plant (STP) in order to assess their potential to replace conventional fertilization (100 kg N/ha, 75 kg P2O5/ha and 75 kg Κ2O/ha) and irrigation. Tap water and treated wastewater were used for irrigation in quantities corresponding to 6500 m3/ha. Four different treatment combinations were applied as follows: (a) wastewater irrigation and conventional fertilization, (b) wastewater irrigation and sewage sludge fertilization, (c) tap water irrigation and sewage sludge fertilization, and (d) tap water irrigation and conventional fertilization. The dry plant biomass collected in the final harvest (140 days after plant emergence) from the four treatment plots was 12.3 t/ha, 12.6 t/ha, 12.4 t/ha and 12.8 t/ha respectively. These differences were not statistically significant (ANOVA, P = 0.05) and, therefore, it was concluded that the use of municipal wastes had similar effects on dry biomass production with that of conventional fertilization. An earlier harvest (125 days after plant emergence) gave 11.3% lower dry biomass on average in relation to the second harvest, and this difference was statistically significant (ANOVA, P = 0.05). Premature harvest may lead to significant biomass losses, so the plant must be collected during its technological maturity stage. There was not any statistically significant difference among the four treatments and between the two harvests in fiber dimensions and derived values (suitability indices for paper manufacture). On the other hand, cellulose and lignin content in the second harvest were significantly higher compared to the first one, whereas no significant differences were detected among the four treatments. © 2016 Elsevier B.V.
Nikolaou A, Kokotos G, Magrioti V. Efficient microwave-assisted synthesis of hydroxymethyl ketones using NHC organocatalysts. Tetrahedron. 2016;72:7628-7632.Abstract
Hydroxymethyl ketones are useful auxiliaries in organic synthesis and are also found in several medicinal agents. N-Heterocyclic carbenes (NHCs) have been used in the literature in order to introduce the hydroxymethyl group into aromatic aldehydes in good yields, but they are not that successful for aliphatic aldehydes. In the present work, the use of microwave irradiation has been efficiently incorporated into this organocatalytic synthesis of aromatic, but more importantly of aliphatic hydroxymethyl ketones that can be used as precursors for medicinally interesting compounds.
Kritikou V. El ambiente selvático en Cajambre de Armando Romero. In: Perspectivas de la novela hispanoamericana. Madrid: Ediciones del Orto; 2016. pp. 89-97. el_ambiente_selvatico_en_cajambre_de_armando_romero.1-6.89-97.pdf
Kritikou V. El ámbito geográfico boliviano en Aluvión de Fuego de Óscar Cerruto. In: Europa Balcánica y Los Países de la Cuenca del Mar Negro - Mercosur: Escenarios sociopolíticos, culturales e Integracionistas - Posibilidades y Desafíos. 1st ed. Belgrado: Universidad "John Naisbitt"; 2016. pp. 193-201. el_ambito_geografico_boliviano_en_aluvion_de_fuego_de_oscar_cerruto.197-206.pdf
Kerimis D, Kontos CK, Christodoulou S, Papadopoulos IN, Scorilas A. Elevated expression of miR-24-3p is a potentially adverse prognostic factor in colorectal adenocarcinoma. Clinical Biochemistry. 2016.
Zagouri F, Terpos E, Kastritis E, Dimopoulos MA. Emerging antibodies for the treatment of multiple myeloma. Expert Opinion on Emerging Drugs [Internet]. 2016;21(2):225 - 237. WebsiteAbstract
ABSTRACT: Introduction: Monoclonal antibodies mark the beginning of a new era in the context of multiple myeloma (MM) treatment. Numerous antibodies have been tested or are currently in development for patients with MM, in order to improve tolerability and quality of life. Areas covered: This manuscript reviews emerging antibodies for the treatment of MM i.e. elotuzumab, daratumumab, MOR03087, isatuximab, bevacizumab, cetuximab, siltuximab, tocilizumab, elsilimomab, azintrel, rituximab, tositumomab, milatuzumab, lucatumumab, dacetuzumab, figitumumab, dalotuzumab, AVE1642, tabalumab, pembrolizumab, pidilizumab, nivolumab. Expert opinion: Amongst these antibodies, elotuzumab which targets SLAMF-7 and daratumumab which targets CD38, have been recently approved by FDA for patients with relapsed/refractory MM. Both agents are well tolerated. Multiple clinical trials incorporating these monoclonal antibodies in MM treatment are currently ongoing. Of special interest are the anticipated results of phase III clinical trials with elotuzumab [NCT0189164; NCT01335399; NCT02495922] and daratumumab [NCT02252172; NCT02195479] in newly diagnosed MM patients. Moreover, of great interest are the awaited data on pembrolizumabin combination with pomalidomide and dexamethasone in refractory/relapsed MM patients [NCT02576977] and in combination with lenalidomide and dexamethasone in newly diagnosed MM patients. It seems that the incorporation of monoclonal antibodies will change the landscape of myeloma therapy in the near future. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
Zagouri F, Terpos E, Kastritis E, Dimopoulos MA. Emerging antibodies for the treatment of multiple myeloma. Expert Opinion on Emerging Drugs [Internet]. 2016;21(2):225 - 237. WebsiteAbstract
ABSTRACT: Introduction: Monoclonal antibodies mark the beginning of a new era in the context of multiple myeloma (MM) treatment. Numerous antibodies have been tested or are currently in development for patients with MM, in order to improve tolerability and quality of life. Areas covered: This manuscript reviews emerging antibodies for the treatment of MM i.e. elotuzumab, daratumumab, MOR03087, isatuximab, bevacizumab, cetuximab, siltuximab, tocilizumab, elsilimomab, azintrel, rituximab, tositumomab, milatuzumab, lucatumumab, dacetuzumab, figitumumab, dalotuzumab, AVE1642, tabalumab, pembrolizumab, pidilizumab, nivolumab. Expert opinion: Amongst these antibodies, elotuzumab which targets SLAMF-7 and daratumumab which targets CD38, have been recently approved by FDA for patients with relapsed/refractory MM. Both agents are well tolerated. Multiple clinical trials incorporating these monoclonal antibodies in MM treatment are currently ongoing. Of special interest are the anticipated results of phase III clinical trials with elotuzumab [NCT0189164; NCT01335399; NCT02495922] and daratumumab [NCT02252172; NCT02195479] in newly diagnosed MM patients. Moreover, of great interest are the awaited data on pembrolizumabin combination with pomalidomide and dexamethasone in refractory/relapsed MM patients [NCT02576977] and in combination with lenalidomide and dexamethasone in newly diagnosed MM patients. It seems that the incorporation of monoclonal antibodies will change the landscape of myeloma therapy in the near future. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
Alexakis P, Kenourgios D, Dimitriou D. On emerging stock market contagion: the Baltic region. Research in International Business and Finance [Internet]. 2016;36:312-321. Publisher's VersionAbstract
This study provides new evidence on emerging stock market contagion during the Global Financial crisis (GFC) and the Euro zone Sovereign Debt Crisis (ESDC). Focusing on the three emerging Baltic markets and developed European markets, proxied by the EUROSTOXX50 stock index, we explore asymmetric dynamic conditional correlation dynamics across stable and crisis periods. Empirical evidence indicates a diverse contagion pattern for the Baltic region across the two crises. Latvia and Lithuania were contagious during the GFC, while they were insulated from the adverse effects of the ESDC. On the other hand, Estonia decoupled from the negative consequences during the global turmoil period, but recoupled during the ESDC. The results could be attributed to financial and macroeconomic characteristics of the Baltic countries before and after the turmoil periods and the introduction time of the Euro as a national currency.
Estudios y Homenajes Hispanoamericanos IV. 1st ed. (Pavlakis EP, Symeonidis H, Pajovic S, Drosos DL, Kritikou V). Madrid: Ediciones del Orto; 2016 pp. 458. Publisher's Version
Estudios y Homenajes Hispanoamericanos IV. 1st ed. (Pavlakis EP, Symeonidis H, Pajovic S, Drosos DL, Kritikou V). Madrid: Ediciones del Orto; 2016 pp. 458. Publisher's Version
Pavlakis EP. Nuevas perspectivas en los cuentos de Onelio Jorge Cardoso. 1st ed. Madrid: Ediciones del Orto; 2016.
Kritikou V. Perspectivas de la novela hispanoamericana. 1st ed. Madrid: Ediciones del Orto; 2016 pp. 100.
Varytis P, Pantazopoulos PA, Stefanou N. Enhanced Faraday rotation by crystals of core-shell magnetoplasmonic nanoparticles. Physical Review B. 2016;93(21):214423 (7 pages).Abstract
Collective hybridized plasmon modes, which enable strong magnetooptical coupling and consequent enhanced Faraday effect in three-dimensional periodic assemblies of magnetic dielectric nanoparticles coated with a noble-metal shell, are studied by means of rigorous full electrodynamic calculations using an extension of the layer-multiple-scattering method, in conjunction with the effective-medium approximation. A thorough analysis of relevant photonic dispersion diagrams and transmission spectra provides a consistent explanation of the underlying physical mechanisms to a degree that goes beyond existing interpretation. It is shown that properly designed structures of such composite magnetoplasmonic nanoparticles offer a versatile platform for engineering increased and broadband Faraday rotation.
Papageorgiou F, Godelitsas A, Mertzimekis TJ, Xanthos S, Voulgaris N, Katsantonis G. Environmental impact of phosphogypsum stockpile in remediated Schistos waste site (Piraeus, Greece) using a combination of $\gamma$-ray spectrometry with geographic information systems. Environmental Monitoring and Assessment. 2016;188:1–14.Abstract
From 1979 to 1989, ten million tons of phosphogypsum, a waste by-product of the Greek phosphate fertilizer industry, was disposed into an abandoned limestone quarry in Schistos former waste site, Piraeus (Greece). The quarry has been recently closed and remediated using geomembranes and thick soil cover with vegetation. A part of the deposited phosphogypsum has been exposed due to intense rainfall episodes leading to concerns about how could potentially released radioactivity affect the surrounding environment. This study seeks to assess the environmental impact of the phosphogypsum deposited in the Schistos quarry, using laboratory-based $\gamma$-ray spectrometry measurements and geographical information systems. Radioactivity concentrations were mapped onto spatial-data to yield a spatial-distribution of radioactivity in the area. The data indicate elevated 226Ra concentrations in a specific area on the steep south-eastern cliff of the remediated waste site that comprises uncovered phosphogypsum and is known to be affected by local weather conditions. 226Ra concentrations range from 162 to 629 Bq/kg, with an average activity being on the low side, compared to the global averages for phosphogypsum. Nevertheless, the low environmental risk may be minimized by remediating this area with geomembranes and thick soil cover with vegetation, a technique, which has worked successfully over the remainder of the remediated quarry.
Engert A, Balduini C, Brand A, Coiffier B, Cordonnier C, Döhner H, De Wit TD, Eichinger S, Fibbe W, Green T, et al. The european hematology association roadmap for european hematology research: A consensus document. Haematologica [Internet]. 2016;101(2):115 - 208. WebsiteAbstract
The European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better funded, more focused European hematology research. Initiated by the EHA, around 300 experts contributed to the consensus document, which will help European policy makers, research funders, research organizations, researchers, and patient groups make better informed decisions on hematology research. It also aims to raise public awareness of the burden of blood disorders on European society, which purely in economic terms is estimated at ∈ European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better fu treatments, sometimes in revolutionary ways. This progress highlights the potential of focused basic research programs such as this EHA Roadmap. The EHA Roadmap identifies nine ‘sections’ in hematology: normal hematopoiesis, malignant lymphoid and myeloid diseases, anemias and related diseases, platelet disorders, blood coagulation and hemostatic disorders, transfusion medicine, infections in hematology, and hematopoietic stem cell transplantation. These sections span 60 smaller groups of diseases or disorders. The EHA Roadmap identifies priorities and needs across the field of hematology, including those to develop targeted therapies based on genomic profiling and chemical biology, to eradicate minimal residual malignant disease, and to develop cellular immunotherapies, combination treatments, gene therapies, hematopoietic stem cell treatments, and treatments that are better tolerated by elderly patients. © 2016 Ferrata Storti Foundation.
Nastos PT, Kapsomenakis J, Philandras KM. Evaluation of the TRMM 3B43 gridded precipitation estimates over Greece. Atmospheric Research [Internet]. 2016;169:497 - 514. Website
Sakelliou A, Fatouros IG, Athanailidis I, Tsoukas D, Chatzinikolaou A, Draganidis D, Jamurtas AZ, Liacos C, Papassotiriou I, Mandalidis D, et al. Evidence of a Redox-Dependent Regulation of Immune Responses to Exercise-Induced Inflammation. Oxidative Medicine and Cellular Longevity [Internet]. 2016;2016. WebsiteAbstract
We used thiol-based antioxidant supplementation (n-acetylcysteine, NAC) to determine whether immune mobilisation following skeletal muscle microtrauma induced by exercise is redox-sensitive in healthy humans. According to a two-trial, double-blind, crossover, repeated measures design, 10 young men received either placebo or NAC (20mg/kg/day) immediately after a muscledamaging exercise protocol (300 eccentric contractions) and for eight consecutive days. Blood sampling and performance assessments were performed before exercise, after exercise, and daily throughout recovery. NAC reduced the decline of reduced glutathione in erythrocytes and the increase of plasma protein carbonyls, serum TAC and erythrocyte oxidized glutathione, and TBARS and catalase activity during recovery thereby altering postexercise redox status. The rise of muscle damage and inflammatory markers (muscle strength, creatine kinase activity, CRP, proinflammatory cytokines, and adhesion molecules) was less pronounced in NAC during the first phase of recovery. The rise of leukocyte and neutrophil count was decreased by NAC after exercise. Results on immune cell subpopulations obtained by flow cytometry indicated that NAC ingestion reduced the exerciseinduced rise of total macrophages, HLA+ macrophages, and 11B+ macrophages and abolished the exercise-induced upregulation of B lymphocytes. Natural killer cells declined only in PLA immediately after exercise. These results indicate that thiol-based antioxidant supplementation blunts immune cell mobilisation in response to exercise-induced inflammation suggesting that leukocyte mobilization may be under redox-dependent regulation. Copyright © 2016 Alexandra Sakelliou et al.
Khaliel A, Mertzimekis TJ, Psaltis A, Psyrra I, Lagaki V, Foteinou V, Axiotis M, Harissopulos S. Experimental Investigation of radiative proton-capture reactions relevant to Nucleosynthesis. In: Hellenic Nuclear Physics Society; 2016.
Kritsi E, Matsoukas M-T, Potamitis C, Karageorgos V, Detsi A, Magafa V, Liapakis G, Mavromoustakos T, Zoumpoulakis P. Exploring new scaffolds for angiotensin II receptor antagonism. Bioorganic and Medicinal Chemistry [Internet]. 2016;24(18):4444 - 4451. Website
Papaioannou D, Peroulis S, Mertzimekis TJ. Exploring the feasibility of magnetic moment measurements in the exotic $^{20}$C nucleus using LISE++ calculations. In: Hellenic Nuclear Physics Society; 2016.
Liontos M, Trigka E-A, Korkolopoulou P, Tzannis K, Lainakis G, Koutsoukos K, Kostouros E, Lykka M, Papandreou CN, Karavasilis V, et al. Expression and prognostic significance of VEGF and mTOR pathway proteins in metastatic renal cell carcinoma patients: a prognostic immunohistochemical profile for kidney cancer patients. World Journal of Urology [Internet]. 2016:1 - 9. WebsiteAbstract
Purpose: To identify prognostic molecular profiles in patients with mRCC treated with sunitinib, we performed immunohistochemical analysis for VEGF and PI3K/Akt/mTOR pathway components. Methods: The immunohistochemical expression of VEGF, p85α, p110γ, PTEN, p-Akt, p-mTOR, p-4E-BP1 and p-p70S6K was studied in 79 patients with mRCC who received first-line treatment with sunitinib. Expression was correlated with clinicopathological features and survival. Results: VEGF was highly expressed (median H-Score 150), while positivity for the markers of the PI3K/Akt/mTOR pathway was: p85α 43/66 (65 %), p110γ41/60 (68 %), PTEN 32/64 (50 %), p-Akt57/63 (90 %), p-mTOR48/64 (75 %), p-4E-BP1 58/64 (90 %) and p-p70S6K 60/65 (92 %). No single immunohistochemical marker was found to have prognostic significance. Instead, the combination of increased p-mTOR and low VEGF expression was adversely correlated with overall survival (OS) (3.2 vs. 16.9 months, P = 0.001). Conclusion: Immunohistochemistry for VEGF and p-mTOR proteins may discriminate patients refractory to first-line sunitinib with poor prognosis. Prospective validation of our findings is needed. © 2016 Springer-Verlag Berlin Heidelberg
Liontos M, Trigka E-A, Korkolopoulou P, Tzannis K, Lainakis G, Koutsoukos K, Kostouros E, Lykka M, Papandreou CN, Karavasilis V, et al. Expression and prognostic significance of VEGF and mTOR pathway proteins in metastatic renal cell carcinoma patients: a prognostic immunohistochemical profile for kidney cancer patients. World Journal of Urology [Internet]. 2016:1 - 9. WebsiteAbstract
Purpose: To identify prognostic molecular profiles in patients with mRCC treated with sunitinib, we performed immunohistochemical analysis for VEGF and PI3K/Akt/mTOR pathway components. Methods: The immunohistochemical expression of VEGF, p85α, p110γ, PTEN, p-Akt, p-mTOR, p-4E-BP1 and p-p70S6K was studied in 79 patients with mRCC who received first-line treatment with sunitinib. Expression was correlated with clinicopathological features and survival. Results: VEGF was highly expressed (median H-Score 150), while positivity for the markers of the PI3K/Akt/mTOR pathway was: p85α 43/66 (65 %), p110γ41/60 (68 %), PTEN 32/64 (50 %), p-Akt57/63 (90 %), p-mTOR48/64 (75 %), p-4E-BP1 58/64 (90 %) and p-p70S6K 60/65 (92 %). No single immunohistochemical marker was found to have prognostic significance. Instead, the combination of increased p-mTOR and low VEGF expression was adversely correlated with overall survival (OS) (3.2 vs. 16.9 months, P = 0.001). Conclusion: Immunohistochemistry for VEGF and p-mTOR proteins may discriminate patients refractory to first-line sunitinib with poor prognosis. Prospective validation of our findings is needed. © 2016 Springer-Verlag Berlin Heidelberg
Drivalos A, Chrisofos M, Efstathiou E, Kapranou A, Kollaitis G, Koutlis G, Antoniou N, Karanastasis D, Dimopoulos MA, Bamias A. Expression of α5-integrin, α7-integrin, Ε-cadherin, and N-cadherin in localized prostate cancer. Urologic Oncology: Seminars and Original Investigations [Internet]. 2016;34(4):165.e11 - 165.e18. WebsiteAbstract
Objective: To explore the correlation between the expression of α5-integrin, α7-integrin, Ε-cadherin, and N-cadherin in prostate cancer (PCa) and its clinicopathological data including tumor grade and clinical stage. Methods: The expression of α5-integrin, α7-integrin, Ε-cadherin, and N-cadherin was examined in 157 cases of PCa and adjacent normal prostatic tissue by immunohistochemical assay, and the correlation with clinicopathological features was analyzed. Results: Expressions of α5-integrin, α7-integrin, and Ε-cadherin in PCa were lower than those in normal prostatic tissues (P<0.05). N-cadherin expression was higher in cancer prostatic tissue than in normal prostatic tissues (P<0.05). The reduced expression of α5-integrin, α7-integrin, and Ε-cadherin was related to Gleason score, pathological stage, lymph node metastasis, and prostate-specific antigen level, but it was not associated with positive surgical margins and patient age. The increased expression of N-cadherin was related to Gleason score, pathological stage, lymph node metastasis, and prostate-specific antigen level, but not to age and positive surgical margins. The expression of E-cadherin was highly negatively correlated with that of N-cadherin and also positively correlated with that of α5-integrin and α7-integrin. Conclusion: The reduced expression of α5-integrin, α7-integrin, and Ε-cadherin and abnormal expression of N-cadherin play an important role in the occurrence and development of PCa. The results indicate that these have potential values in the diagnosis and are predictable indices in the proliferation of PCa. © 2016 Elsevier Inc.
Drivalos A, Chrisofos M, Efstathiou E, Kapranou A, Kollaitis G, Koutlis G, Antoniou N, Karanastasis D, Dimopoulos MA, Bamias A. Expression of α5-integrin, α7-integrin, Ε-cadherin, and N-cadherin in localized prostate cancer. Urologic Oncology: Seminars and Original Investigations [Internet]. 2016;34(4):165.e11 - 165.e18. WebsiteAbstract
Objective: To explore the correlation between the expression of α5-integrin, α7-integrin, Ε-cadherin, and N-cadherin in prostate cancer (PCa) and its clinicopathological data including tumor grade and clinical stage. Methods: The expression of α5-integrin, α7-integrin, Ε-cadherin, and N-cadherin was examined in 157 cases of PCa and adjacent normal prostatic tissue by immunohistochemical assay, and the correlation with clinicopathological features was analyzed. Results: Expressions of α5-integrin, α7-integrin, and Ε-cadherin in PCa were lower than those in normal prostatic tissues (P<0.05). N-cadherin expression was higher in cancer prostatic tissue than in normal prostatic tissues (P<0.05). The reduced expression of α5-integrin, α7-integrin, and Ε-cadherin was related to Gleason score, pathological stage, lymph node metastasis, and prostate-specific antigen level, but it was not associated with positive surgical margins and patient age. The increased expression of N-cadherin was related to Gleason score, pathological stage, lymph node metastasis, and prostate-specific antigen level, but not to age and positive surgical margins. The expression of E-cadherin was highly negatively correlated with that of N-cadherin and also positively correlated with that of α5-integrin and α7-integrin. Conclusion: The reduced expression of α5-integrin, α7-integrin, and Ε-cadherin and abnormal expression of N-cadherin play an important role in the occurrence and development of PCa. The results indicate that these have potential values in the diagnosis and are predictable indices in the proliferation of PCa. © 2016 Elsevier Inc.
Maliverno E, Karatsolis B-T, Dimiza M, Lagaria A, Psarra S, Triantaphyllou M. Extant silicoflagellates from the Northeast Aegean (eastern Mediterranean Sea): Morphologies and double skeletons. Revue de micropaléontologie [Internet]. 2016;59:253–265. Publisher's VersionAbstract
Silicoflagellate abundance, vertical distribution and morphology were studied during spring (March 2014) at three sampling stations locatedin the Northeast Aegean Sea adjacent to the Dardanelles Strait and characterized by a variable influx of cold, low-salinity Black Sea water.The silicoflagellate assemblage was dominated by Dictyocha stapedia and Stephanocha speculum with minor contribution of D. aculeata andOctactis pulchra. While specimens of D. stapedia were represented by the typical morphologies described in other areas of the Mediterranean Sea,populations of S. speculum displayed peculiar characters: they were large, predominantly 7-sided, with a small apical ring as well as apical ringspines, concave basal ring sides and non-rotated apical structure. Some of these features have been described for S. speculum at high latitudes, butthe combined characters make these specimens slightly different from the high latitude populations. Similar morphologies have been observed inthe western Black Sea, thus we can infer that the peculiar specimens detected in the Northeast Aegean are associated with the influx of Black Seawater masses.
Dalamaga M, Polyzos SA, Karmaniolas K, Chamberland J, Lekka A, Triantafilli M, Migdalis I, Papadavid E, Mantzoros CS. Fetuin-A levels and free leptin index are reduced in patients with chronic lymphocytic leukemia: a hospital-based case-control study. Leuk Lymphoma. 2016;57(3):577-84.Abstract
There are limited data on fetuin-A, soluble leptin receptor (sOB-R) and free leptin index (FLI) in patients with chronic lymphocytic leukemia (CLL). The aim of this study was to compare circulating fetuin-A, sOB-R levels and FLI between 95 patients with CLL and 95 matched controls, as well as among different stages of CLL. Circulating fetuin-A was significantly lower in cases than controls (241.9 ± 99.2 vs. 288.8 ± 127.7 μg/mL; p = 0.005). Although circulating sOB-R levels were similar between groups, FLI was lower in cases than controls (0.45 ± 0.42 vs. 0.67 ± 0.57; p = 0.003). Furthermore, lower fetuin-A or FLI, but not sOB-R, were independently associated with CLL (p < 0.05), particularly among overweight/obese individuals. Fetuin-A, s-OB-R and FLI were similar between different stages of CLL severity, or between symptomatic and asymptomatic disease. In conclusion, circulating fetuin-A and FLI, but not sOB-R, were lower in patients with CLL than controls, a finding warranting further investigation.
Belasen A, Brock K, Li B, Chremou D, Valakos E, Pafilis P, Sinervo B, Foufopoulos J. Fine with heat, problems with water: Microclimate alters water loss in a thermally adapted insular lizard. Oikos [Internet]. 2016. Website
Dimiza, M., Triantaphyllou, M., Koukousioura, O., Hallock, P., Simboura, N., Karageorgis, A.P., Papathanasiou, E. The Foram Stress Index: A new tool for environmental assessment of soft-bottom environments using benthic foraminifera. A case study from the Saronikos Gulf, Greece, Eastern Mediterranean. Ecological Indicators [Internet]. 2016;60:611-621. Publisher's VersionAbstract
Saronikos Gulf, including the industrial zone of Elefsis Bay and the Port of Piraeus, is one of the most anthropogenically impacted coastal regions of Greece. Distinct assemblages of benthic foraminifers in sediment samples, collected from this gulf in February 2012, defined three zones that reflect abiotic parameters of the sediments (e.g., organic carbon, metal content). A low-diversity assemblage, dominated by stress-tolerantAmmonia tepida and Bulimina spp., was characteristic of samples from Elefsis Bay. Samples from the western and central part of Saronikos Gulf were the most variable with respect to both abiotic parameters and the foraminiferal assemblage, characterized by a mix of stress-tolerant and more sensitive taxa, especially Bolivina spp. andNonion fabum. Samples from the coast of Salamis and at the eastern sector of the gulf were characterized by a diverse assemblage that included Peneroplis pertusus, miliolids, and a variety of small, epiphytic rotaliid taxa. A new biotic index, the Foram Stress Index (FSI), is based on the relative percentages of two ecological groups of benthic foraminiferal species, grouped according to their tolerance/sensitivity to organic matter enrichment and weighted proportionately to obtain a formula to define five ecological-status classes. The FSI produced three rankings for these samples (Poor, Moderate and Good), that strongly correlate with the macroinvertebrate-classification tool known as the BENTIX Index. The FSI provides a new tool to assess sediment or substrata quality based upon the benthic foraminiferal assemblages, which are a significant component of living meiobenthic communities that are generally not considered in most biotic benthic indices.
Dimiza, M., Triantaphyllou, M., Koukousioura, O., Hallock, P., Simboura, N., Karageorgis, A.P., Papathanasiou, E. The Foram Stress Index: A new tool for environmental assessment of soft-bottom environments using benthic foraminifera. A case study from the Saronikos Gulf, Greece, Eastern Mediterranean. Ecological Indicators [Internet]. 2016;60:611-621. Publisher's VersionAbstract
Saronikos Gulf, including the industrial zone of Elefsis Bay and the Port of Piraeus, is one of the most anthropogenically impacted coastal regions of Greece. Distinct assemblages of benthic foraminifers in sediment samples, collected from this gulf in February 2012, defined three zones that reflect abiotic parameters of the sediments (e.g., organic carbon, metal content). A low-diversity assemblage, dominated by stress-tolerantAmmonia tepida and Bulimina spp., was characteristic of samples from Elefsis Bay. Samples from the western and central part of Saronikos Gulf were the most variable with respect to both abiotic parameters and the foraminiferal assemblage, characterized by a mix of stress-tolerant and more sensitive taxa, especially Bolivina spp. andNonion fabum. Samples from the coast of Salamis and at the eastern sector of the gulf were characterized by a diverse assemblage that included Peneroplis pertusus, miliolids, and a variety of small, epiphytic rotaliid taxa. A new biotic index, the Foram Stress Index (FSI), is based on the relative percentages of two ecological groups of benthic foraminiferal species, grouped according to their tolerance/sensitivity to organic matter enrichment and weighted proportionately to obtain a formula to define five ecological-status classes. The FSI produced three rankings for these samples (Poor, Moderate and Good), that strongly correlate with the macroinvertebrate-classification tool known as the BENTIX Index. The FSI provides a new tool to assess sediment or substrata quality based upon the benthic foraminiferal assemblages, which are a significant component of living meiobenthic communities that are generally not considered in most biotic benthic indices.
Drinia, H., Antonarakou, A., Tsourou, T., Kontakiotis, G., Psychogiou, M., Anastasakis, G. Foraminifera eco-biostratigraphy of the southern Evoikos outer shelf, central Aegean Sea, during MIS 5 to present. Continental Shelf Research [Internet]. 2016;126:36-49. Publisher's Version
Georgiopoulos GA, Lambrinoudaki I, Athanasouli F, Armeni E, Rizos D, Kazani M, Karamanou M, Manios E, Augoulea A, Stellos K, et al. Free androgen index as a predictor of blood pressure progression and accelerated vascular aging in menopause. Atherosclerosis. 2016;247:177 - 183.Abstract
© 2016 Elsevier Ireland Ltd. Background and aims: We aimed to assess the prognostic value of free androgen index (FAI) and its change over time in arterial stiffness progression, endothelial function and hypertension in postmenopausal women. Methods: Postmenopausal women (n = 180) without clinically overt cardiovascular disease or diabetes were consecutively recruited and followed for a median of 29 months. The main outcome measures were changes over time in endothelial function (FMD), reflected waves, localized and systemic (PWV) arterial stiffness and hypertension. Results: Increased baseline FAI was significantly associated with new onset hypertension (OR for each SD, 2.71, 95% CI 1.14-6.41, p = 0.024), deterioration of pulse wave velocity (PWV) (0.414 m/s per SD), flow-mediated dilation (FMD) (-0.42% per SD), systolic (2.5 mmHg per SD) and pulse pressure progression (2.3 mmHg per SD, p < 0.05 for all). Baseline FAI remained an independent predictor of changes in PWV (p = 0.006), FMD (p = 0.02), peripheral pulse pressure (p = 0.028), transition to new onset hypertension (p = 0.001) and higher BP category (p = 0.012), after adjustment for age, changes in systolic blood pressure, traditional risk factors, vasoactive medication or total testosterone. Baseline FAI improved reclassification for the risk of transition into higher BP category (NRI = 47.5 ± 20.3%, p = 0.02) and abnormal PWV (NRI = 53.4 ± 23.2%, p = 0.021). Similarly, in a subgroup of patients with measured FAI at follow-up, its changes over time predicted changes in PWV, peripheral pulse pressure and hypertension status (p < 0.05 for all). Conclusions: In apparently healthy postmenopausal women, FAI could be a novel biomarker superior to total testosterone for accelerated vascular aging and hypertension status.
Arabatzis T, Gavroglu K. From Discrepancy to Discovery: How Argon Became an Element. In: T. Sauer & R. Scholl (eds), The Philosophy of Historical Case Studies. Dordrecht: Springer; 2016. pp. 203-222. Publisher's VersionAbstract
In this paper, we revisit the discovery of argon by Lord Rayleigh and William Ramsay. We argue that to understand historically how argon was detected, conceptualized, and accommodated into chemical knowledge we need to take into account the philosophical insight that scientific discovery is often an extended process. One of argon’s most intriguing properties was that it did not react with other elements. Reactivity, however, had been a constitutive property of elements. Thus, the discovery of argon could not have been accepted by chemists without a reconceptualization of ‘element’. Furthermore, there were difficulties with the accommodation of argon in the Periodic table, because argon appeared to undermine the conception of matter that underlay the Periodic table. The discovery of argon was complete only after those conceptual difficulties had been removed. This is why it has to be understood as an extended process, rather than as an event. Furthermore, we will suggest that some of the factors that complicated the discovery of argon were related to the legitimization of physical techniques of investigation in chemistry and the emergence of physical chemistry.
Goulas V, Stylos E, Chatziathanasiadou MV, Mavromoustakos T, Tzakos AG. Functional components of carob fruit: Linking the chemical and biological space. International Journal of Molecular Sciences [Internet]. 2016;17(11). Website
Goulas V, Stylos E, Chatziathanasiadou MV, Mavromoustakos T, Tzakos AG. Functional components of carob fruit: Linking the chemical and biological space. International Journal of Molecular Sciences [Internet]. 2016;17(11). Website
Chrysostomou S. Further Perspectives 2A. In: Oxford Handbook of Technology & Music Education. Oxford: Oxford University Press; 2016.
Kamberidou I. "A Futurist and Hybrid Scientist, the result of a Multidisciplinary Education". Irene Kamberidou interviews Eleni Antoniadou, multidisciplinary scientist in Artificial Organ Technology and President of the European Health Parliament. Interview for 1st European Celebration of Women in Computing (ECWC), Brussels, 25-26 April 2016 (womenincomputing.eu), organized by European European Centre for Women and Technology (ECWT):. 2016.Abstract
When citing:  Kamberidou, Irene (2016).  A Futurist and Hybrid Scientist, the result of a Multidisciplinary Education. Irene Kamberidou interviews Eleni Antoniadou, multidisciplinary scientist in Artificial Organ Technology and President of the European Health Parliament, 04/14/2016 - 12:25:  http://www.womenincomputing.eu/blog/470/futurist-and-hybrid-scientist-result-multidisciplinary-education-irene-kamberidou-ecwt    Interview for  1st European Celebration of Women in Computing (ECWC), Brussels, 25-26 April 2016! (womenincomputing.eu), organized by European European Centre for Women and Technology (ECWT): SPONSORS: http://womenincomputing.eu/sponsors Website: www.ecwt.eu
a_futurist_and_hybrid_scientist.pdf a_futurist_and_hybrid_scientist.pdf
Charitaki E, Kastritis E, Petraki C, Liapis K, Adamidis K, Apostolou T, Christodoulidou C, Nikolopoulou N, Terpos E, Nakopoulou L, et al. Glomerular expression of matrix metalloproteinases in AL-amyloidosis and association with renal function at the time of kidney biopsy. Clinical Nephrology [Internet]. 2016;85(1):44 - 52. WebsiteAbstract
Background: Matrix metalloproteinases (MMPs) have been implicated in the pathophysiology of various renal diseases, however, there are limited data regarding their role in renal AL-amyloidosis. In the present study, we evaluated the glomerular expression of MMPs in renal-biopsy specimens containing AL-amyloid deposits. We also examined the association of MMPs with renal function at the time of diagnostic renal biopsy. Methods: We performed immunohistochemistry with monoclonal antibodies against MMP-1, MMP-2, MMP-3, MMP-9, and TIMP-1 in 19 kidney-biopsy specimens with AL-amyloidosis and 8 specimens from normal kidney tissue. We used clinical data of the patients at the time of kidney biopsy to evaluate the association between MMP expression and renal function. Results: We found increased MMP-1 and MMP-3 expression within the amyloid deposits and adjacent tissues in > 50% of the amyloid-positive biopsies, whereas MMP-1 and MMP-3 were negative in control samples. In contrast, we found no significant glomerular MMP-2 and TIMP-1 expression in amyloid-containing or normal kidneys. MMP-9 expression was found in the glomerular basement membrane equally in AL-amyloidosis and control specimens. The presence of MMP-1 and MMP-3 in the glomeruli of patients with AL-amyloidosis correlated with worse renal function at the time of kidney biopsy. Conclusion: The findings of this study show increased glomerular expression of MMP-1 and MMP-3 in patients with AL-amyloidosis which is associated with worse renal function at the time of the kidney biopsy. Our results suggest an important role for MMP-1 and MMP-3 in the pathogenesis of renal damage in AL-amyloidosis. © 2016 Dustri-Verlag Dr. K. Feistle.
Greek Art and Archaeology, 1200-30 BC. Atlanta: Lockwood Press; 2016. Publisher's VersionAbstract
Τhis lavishly illustrated book surveys Greek archaeology from the collapse of the Mycenaean palaces to the subordination of the last Hellenistic kingdoms to Rome. Its aim is to study Greek art through the material record, and against its cultural and social backdrop. The book's target audience is archaeology and art students, as well as anyone interested in Greek art and culture. Through concise, systematic covering of the main categories of classical monuments, the reader is taken to a tour of ancient Greece along the most spectacular period in its history, the 1st millennium BC. Architecture and city planning, sculpture, painting, pottery, metallurgy, jewelry, and numismatics are some of the areas covered.
Kamberidou I, Chroni S. The Greek Experience: Outstanding Women in the Social Space of Sport. In: Inspirational Women in Europe: making a difference in Physical Education, Sport and Dance. Juiz de Fora, Brazil.: Rosa Diketmüller (editor). Juiz de Fora : NGIME/UFJF, 2016. 254 p. (IAPESGW Continent Series). Publication of the International Association of Physical Education and Sport for Girls and Women (IAPESGW), ISBN 978-85-67380-55-1; 2016. pp. 224–242.Abstract
The Voices of Six Inspirational Greek Women in Sport: What inspired them to take that leap; the Obstacles they faced; how they moved forward and Tips for Success.  Many inspirational and outstanding women have made a difference in the lives of girls and women in sport, physical education (PE) and physical activity in Greece, despite their invisibility in the mainstream media, the life stories of which would need volumes. They succeeded in making a difference while respecting and celebrating diversity with regard to gender, ethnicity, culture, disability, age and sexual orientation. Beginning with a brief discussion on the underrepresentation of women’s sports and the female athlete in the Greek media, this chapter shares the contributions of some inspiring and motivating Greek women in sport whose achievements have been excluded from the country’s mainstream media. It is through six in-depth interviews and follow-up meetings that we learn how these pioneers influenced the lives of sporting girls and women by daring to disregard social barriers and spread awareness. We conclude the chapter with tips from these successful, namely inspirational women, who all agree that success requires ethos and taking that leap.http://www.ngime.ufjf.br/wp-content/uploads/Europa_opt.pdf
inspirational_women_in_europe_0330_continentes_europa.pdf book_cover_inspiratoinal_women_in_sport.jpg inspirational_women_hardcopy_sample.pdf inspirational_women_in_europe_making_a_difference_in_phys.ed_.sport_and_dance.pdf
Lambrinoudaki I, Augoulea A, Rizos D, Politi M, Tsoltos N, Moros M, Chinou I, Graikou K, Kouskouni E, Kambani S, et al. Greek-origin royal jelly improves the lipid profile of postmenopausal women. Gynecological Endocrinology [Internet]. 2016:1-5. Website
Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2016;12(1):1-222.
Thodi G, Schulpis KH, Dotsikas Y, Pavlides C, Molou E, Chatzidaki M, Triantafylli O, Loukas YL. Hawkinsinuria in two unrelated Greek newborns: Identification of a novel variant, biochemical findings and treatment. Journal of Pediatric Endocrinology and Metabolism [Internet]. 2016;29:15-20. Website
Moustris KP, Proias GT, Larissi IK, Nastos PT, Koukouletsos KV, Paliatsos AG. Health impacts due to particulate air pollution in Volos City, Greece. Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering [Internet]. 2016;51(1):15 - 20. Website
Stewart AK, Dimopoulos MA, Masszi T, Špička I, Oriol A, Hájek R, Rosiñol L, Siegel DS, Niesvizky R, Jakubowiak AJ, et al. Health-related quality-of-life results from the open-label, randomized, phase III ASPIRE trial evaluating carfilzomib, lenalidomide, and dexamethasone versus lenalidomide and dexamethasone in patientswith relapsed multiple myeloma. Journal of Clinical Oncology [Internet]. 2016;34(32):3921 - 3930. WebsiteAbstract
Purpose To determine the effects of carfilzomib, lenalidomide, and dexamethasone (KRd) versus lenalidomide and dexamethasone (Rd) on health-related quality of life (HR-QoL) in the Carfilzomib, Lenalidomide, and Dexamethasone Versus Lenalidomide and Dexamethasone for the Treatment of Patients With Relapsed Multiple Myeloma (ASPIRE) trial. Methods Patients with relapsed multiple myeloma were randomly assigned to receive KRd or Rd. The European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire C30 and myeloma-specific module were administered at baseline; day 1 of cycles 3, 6, 12, and 18; and after treatment. The Global Health Status/Quality of Life (GHS/QoL) scale and seven subscales (fatigue, nausea and vomiting, pain, physical functioning, role functioning, disease symptoms, and adverse effects of treatment) were compared between groups using a mixed model for repeated measures. The percentages of responders with ≥ 5- or 15-point GHS/QoL improvement at each cycle were compared between groups. Results Baseline questionnaire compliance was excellent (94.1% of randomly assigned patients). KRd patients had higher GHS/QoL scores versus Rd patients over 18 treatment cycles (two-sided P<.001). The minimal important difference was met at cycle 12 (5.6 points) and approached at cycle 18 (4.8 points). There was no difference between groups for the other prespecified subscales from ASPIRE. A higher proportion of KRd patients met the GHS/QoL responder definition (≥ 5-point improvement) with statistical differences at cycle 12 (KRd v Rd patients, 25.5% v 17.4%, respectively) and 18 (KRd v Rd patients, 24.2% v 12.9%, respectively). Conclusion KRd improves GHS/QoL without negatively affecting patient-reported symptoms when compared with Rd. These data further support the benefit of KRd in patients with relapsed multiple myeloma. © 2016 by American Society of Clinical Oncology.
Stewart AK, Dimopoulos MA, Masszi T, Špička I, Oriol A, Hájek R, Rosiñol L, Siegel DS, Niesvizky R, Jakubowiak AJ, et al. Health-related quality-of-life results from the open-label, randomized, phase III ASPIRE trial evaluating carfilzomib, lenalidomide, and dexamethasone versus lenalidomide and dexamethasone in patientswith relapsed multiple myeloma. Journal of Clinical Oncology [Internet]. 2016;34(32):3921 - 3930. WebsiteAbstract
Purpose To determine the effects of carfilzomib, lenalidomide, and dexamethasone (KRd) versus lenalidomide and dexamethasone (Rd) on health-related quality of life (HR-QoL) in the Carfilzomib, Lenalidomide, and Dexamethasone Versus Lenalidomide and Dexamethasone for the Treatment of Patients With Relapsed Multiple Myeloma (ASPIRE) trial. Methods Patients with relapsed multiple myeloma were randomly assigned to receive KRd or Rd. The European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire C30 and myeloma-specific module were administered at baseline; day 1 of cycles 3, 6, 12, and 18; and after treatment. The Global Health Status/Quality of Life (GHS/QoL) scale and seven subscales (fatigue, nausea and vomiting, pain, physical functioning, role functioning, disease symptoms, and adverse effects of treatment) were compared between groups using a mixed model for repeated measures. The percentages of responders with ≥ 5- or 15-point GHS/QoL improvement at each cycle were compared between groups. Results Baseline questionnaire compliance was excellent (94.1% of randomly assigned patients). KRd patients had higher GHS/QoL scores versus Rd patients over 18 treatment cycles (two-sided P<.001). The minimal important difference was met at cycle 12 (5.6 points) and approached at cycle 18 (4.8 points). There was no difference between groups for the other prespecified subscales from ASPIRE. A higher proportion of KRd patients met the GHS/QoL responder definition (≥ 5-point improvement) with statistical differences at cycle 12 (KRd v Rd patients, 25.5% v 17.4%, respectively) and 18 (KRd v Rd patients, 24.2% v 12.9%, respectively). Conclusion KRd improves GHS/QoL without negatively affecting patient-reported symptoms when compared with Rd. These data further support the benefit of KRd in patients with relapsed multiple myeloma. © 2016 by American Society of Clinical Oncology.
Papaioannou TG, Karamanou M, Protogerou AD, Tousoulis D. Heat therapy: an ancient concept re-examined in the era of advanced biomedical technologies. Journal of Physiology [Internet]. 2016;594(23):7141 - 7142. Website
Ziogas DC, Kastritis E, Terpos E, Roussou M, Migkou M, Gavriatopoulou M, Spanomichou D, Eleutherakis-Papaiakovou E, Fotiou D, Panagiotidis I, et al. Hematologic and renal improvement of monoclonal immunoglobulin deposition disease after treatment with bortezomib-based regimens. Leukemia and Lymphoma [Internet]. 2016:1 - 8. WebsiteAbstract
Monoclonal immunoglobulin deposition disease (MIDD) is characterized by non-organized immunoglobulin-fragments along renal basement membranes with subsequent organ deterioration. Treatment is directed against the immunoglobulin-producing clone. We treated 18 MIDD patients with bortezomib-based regimens (12 received bortezomib-dexamethasone, 6 bortezomib-dexamethasone with cyclophosphamide). Eleven (61%) patients achieved a hematologic response, but only 6 (33.3%) reached to a complete (CR) or very good partial response (VGPR). Regarding renal outcomes 77.8 and 55.6% had ≥30 and ≥50% reduction of proteinuria, respectively, but 33.3% ended up in end-stage renal disease (ESRD). Among patients with CR or VGPR, median eGFR improvement was 7.7 ml/min/1.73 m2 and none progressed to ESRD, but no significant renal recovery was observed in patients achieving a partial response or less, with 50% progressing to dialysis. Pretreatment eGFR seems to influence renal prognosis. Bortezomib-based treatment is considered an effective approach in MIDD and reaching to a deep hematologic response (≥VGPR) conditionally controls further renal declining. © 2016 Informa UK Limited, trading as Taylor & Francis Group
Ziogas DC, Kastritis E, Terpos E, Roussou M, Migkou M, Gavriatopoulou M, Spanomichou D, Eleutherakis-Papaiakovou E, Fotiou D, Panagiotidis I, et al. Hematologic and renal improvement of monoclonal immunoglobulin deposition disease after treatment with bortezomib-based regimens. Leukemia and Lymphoma [Internet]. 2016:1 - 8. WebsiteAbstract
Monoclonal immunoglobulin deposition disease (MIDD) is characterized by non-organized immunoglobulin-fragments along renal basement membranes with subsequent organ deterioration. Treatment is directed against the immunoglobulin-producing clone. We treated 18 MIDD patients with bortezomib-based regimens (12 received bortezomib-dexamethasone, 6 bortezomib-dexamethasone with cyclophosphamide). Eleven (61%) patients achieved a hematologic response, but only 6 (33.3%) reached to a complete (CR) or very good partial response (VGPR). Regarding renal outcomes 77.8 and 55.6% had ≥30 and ≥50% reduction of proteinuria, respectively, but 33.3% ended up in end-stage renal disease (ESRD). Among patients with CR or VGPR, median eGFR improvement was 7.7 ml/min/1.73 m2 and none progressed to ESRD, but no significant renal recovery was observed in patients achieving a partial response or less, with 50% progressing to dialysis. Pretreatment eGFR seems to influence renal prognosis. Bortezomib-based treatment is considered an effective approach in MIDD and reaching to a deep hematologic response (≥VGPR) conditionally controls further renal declining. © 2016 Informa UK Limited, trading as Taylor & Francis Group
Paparizos P, Dimitriou D, Kenourgios D, Simos T. On high frequency dynamics between information asymmetry and volatility for securities. Journal of Economic Asymmetries [Internet]. 2016;13:21-34. Publisher's VersionAbstract
This paper investigates the relationship between the volatility of Volume Synchronized Probability of Informed Trading (VPIN) and future short-term volatility of stock returns. We construct a transaction-signed version of VPIN (TR-VPIN) based on tick by tick data on securities traded in the Athens Stock Exchange (ASE) during the Greek sovereign debt crisis. The results show a positive and statistically significant correlation between the volatility of TR-VPIN and future short-term volatility for securities that are exposed to asymmetric information during the period under examination. This evidence expands the existent literature which shows that the absolute order imbalance forecasts absolute returns, suggesting that TR-VPIN is a real-time informative indicator of the Probability of Informed Trading (PIN) in the high frequency domain. Further, the long-range dependence between the conditional volatilities of TR-VPIN and stock returns becomes more significant as we move towards securities which display stronger long memory. This is perfectly in line with the recent empirical evidence in microstructure literature that large past shocks of flow toxicity can lead to volatility through liquidity shortages.
Terpos E, Christoulas D, Kastritis E, Bagratuni T, Gavriatopoulou M, Roussou M, Papatheodorou A, Eleutherakis-Papaiakovou E, Kanellias N, Liakou C, et al. High levels of periostin correlate with increased fracture rate, diffuse MRI pattern, abnormal bone remodeling and advanced disease stage in patients with newly diagnosed symptomatic multiple myeloma. Blood Cancer Journal [Internet]. 2016;6(10):e482. WebsiteAbstract
Periostin is an extracellular matrix protein that is implicated in the biology of normal bone remodeling and in different cancer cell growth and metastasis. However, there is no information on the role of periostin in multiple myeloma (MM). Thus, we evaluated periostin in six myeloma cell lines in vitro; in the bone marrow plasma and serum of 105 newly diagnosed symptomatic MM (NDMM) patients and in the serum of 23 monoclonal gammopathy of undetermined significance (MGUS), 33 smoldering MM (SMM) patients, 30 patients at the plateau phase post-first-line therapy, 30 patients at first relapse and 30 healthy controls. We found high levels of periostin in the supernatants of myeloma cell lines compared with ovarian cancer cell lines that were not influenced by the incubation with the stromal cell line HS5. In NDMM patients the bone marrow plasma periostin was almost fourfold higher compared with the serum levels of periostin and correlated with the presence of fractures and of diffuse magnetic resonance imaging pattern of marrow infiltration. Serum periostin was elevated in NDMM patients compared with healthy controls, MGUS and SMM patients and correlated with advanced disease stage, high lactate dehydrogenase, increased activin-A, increased bone resorption and reduced bone formation. Patients at first relapse had also elevated periostin compared with healthy controls, MGUS and SMM patients, while even patients at the plateau phase had elevated serum periostin compared with healthy controls. These results support an important role of periostin in the biology of myeloma and reveal periostin as a possible target for the development of antimyeloma drugs. © 2016 The Author(s).
Terpos E, Christoulas D, Kastritis E, Bagratuni T, Gavriatopoulou M, Roussou M, Papatheodorou A, Eleutherakis-Papaiakovou E, Kanellias N, Liakou C, et al. High levels of periostin correlate with increased fracture rate, diffuse MRI pattern, abnormal bone remodeling and advanced disease stage in patients with newly diagnosed symptomatic multiple myeloma. Blood Cancer Journal [Internet]. 2016;6(10):e482. WebsiteAbstract
Periostin is an extracellular matrix protein that is implicated in the biology of normal bone remodeling and in different cancer cell growth and metastasis. However, there is no information on the role of periostin in multiple myeloma (MM). Thus, we evaluated periostin in six myeloma cell lines in vitro; in the bone marrow plasma and serum of 105 newly diagnosed symptomatic MM (NDMM) patients and in the serum of 23 monoclonal gammopathy of undetermined significance (MGUS), 33 smoldering MM (SMM) patients, 30 patients at the plateau phase post-first-line therapy, 30 patients at first relapse and 30 healthy controls. We found high levels of periostin in the supernatants of myeloma cell lines compared with ovarian cancer cell lines that were not influenced by the incubation with the stromal cell line HS5. In NDMM patients the bone marrow plasma periostin was almost fourfold higher compared with the serum levels of periostin and correlated with the presence of fractures and of diffuse magnetic resonance imaging pattern of marrow infiltration. Serum periostin was elevated in NDMM patients compared with healthy controls, MGUS and SMM patients and correlated with advanced disease stage, high lactate dehydrogenase, increased activin-A, increased bone resorption and reduced bone formation. Patients at first relapse had also elevated periostin compared with healthy controls, MGUS and SMM patients, while even patients at the plateau phase had elevated serum periostin compared with healthy controls. These results support an important role of periostin in the biology of myeloma and reveal periostin as a possible target for the development of antimyeloma drugs. © 2016 The Author(s).
Rapti S-M, Kontos CK, Papadopoulos IN, Scorilas A. High miR-96 levels in colorectal adenocarcinoma predict poor prognosis, particularly in patients without distant metastasis at the time of initial diagnosis. Tumor Biology. 2016;37:11815-11824.
Heylen H, De Rydt M, Neyens G, Bissell ML, Caceres L, Chevrier R, Daugas JM, Ichikawa Y, Ishibashi Y, Kamalou O, et al. High-precision quadrupole moment reveals significant intruder component in $_{13}^{33}\mathrm{Al}_{20}$ ground state. Phys. Rev. C. 2016;94:034312.
Tsoucalas G, Chevallier J, Karamanou M, Papaioannou T, Sgantzos M, Androutsos G. Historical hallmarks of anticoagulation and antiplatelet agents. Current Pharmaceutical Design [Internet]. 2016;22(13):1857 - 1861. Website
Triantaphyllou, M.  , Gogou, A., Dimiza, M., Kostopoulou, S.  , Parinos, C., Roussakis, G., Geraga, M., Bouloubassi, I., Fleitmann, D., Zervakis, V., et al. Holocene Climate Optimum centennial-scale paleoceanography in the NE Aegean Sea (Mediterranean Sea). Geo-Marine Letters [Internet]. 2016;36:51-66. Publisher's VersionAbstract
Combined micropaleontological and geochemical analyses of the high-sedimentation gravity core M-4G provided new centennial-scale paleoceanographic data for sapropel S1 deposition in the NE Aegean Sea during the Holocene Climatic Optimum. Sapropel layer S1a (10.2–8.0 ka) was deposited in dysoxic to oxic bottom waters characterized by a high abundance of benthic foraminiferal species tolerating surface sediment and/or pore water oxygen depletion (e.g.,Chilostomella mediterranensis, Globobulimina affinis), and the presence of Uvigerina mediterranea, which thrives in oxic mesotrophic-eutrophic environments. Preservation of organic matter (OM) is inferred based on high organic carbon as well as loliolide and isololiolide contents, while the biomarker record and the abundances of eutrophic planktonic foraminifera document enhanced productivity. High inputs of terrigenous OM are attributed to north Aegean borderland riverine inputs. Both alkenone-based sea surface temperatures (SSTs) and δO18 G. bulloides records indicate cooling at 8.2 ka (S1a) and ~7.8 ka (S1 interruption). Sapropelic layer S1b (7.7–6.4 ka) is characterized by rather oxic conditions; abundances of foraminiferal species tolerant to oxygen depletion are very low compared with the U. mediterranea rise. Strongly fluctuating SSTs demonstrate repeated cooling and associated dense water formation, with a major event at 7.4 ka followed by cold spells at 7.0, 6.8, and 6.5 ka. The prominent rise of the carbon preference index within the S1b layer indicates the delivery of less degraded terrestrial OM. The increase of algal biomarkers, labile OM-feeding foraminifera and eutrophic planktonic species pinpoints an enhanced in situ marine productivity, promoted by more efficient vertical convection due to repeated cold events. The associated contributions of labile marine OM along with fresher terrestrial OM inputs after ~7.7 ka imply sources alternative/additional to the north Aegean riverine borderland sources for the influx of organic matter in the south Limnos Basin, plausibly related to the inflow of highly productive Marmara/Black Sea waters.
Triantaphyllou, M., Gogou, A., Dimiza, M., Kostopoulou, S., Parinos, C., Roussakis, G., Geraga, M., Bouloubassi, I., Fleitmann, D., Zervakis, V., et al. Holocene Climate Optimum centennial-scale paleoceanography in the NE Aegean Sea (Mediterranean Sea). Geo-Marine Letters [Internet]. 2016;36:51-66. Publisher's VersionAbstract
Combined micropaleontological and geochemical analyses of the high-sedimentation gravity core M-4G provided new centennial-scale paleoceanographic data for sapropel S1 deposition in the NE Aegean Sea during the Holocene Climatic Optimum. Sapropel layer S1a (10.2–8.0 ka) was deposited in dysoxic to oxic bottom waters characterized by a high abundance of benthic foraminiferal species tolerating surface sediment and/or pore water oxygen depletion (e.g.,Chilostomella mediterranensis, Globobulimina affinis), and the presence of Uvigerina mediterranea, which thrives in oxic mesotrophic-eutrophic environments. Preservation of organic matter (OM) is inferred based on high organic carbon as well as loliolide and isololiolide contents, while the biomarker record and the abundances of eutrophic planktonic foraminifera document enhanced productivity. High inputs of terrigenous OM are attributed to north Aegean borderland riverine inputs. Both alkenone-based sea surface temperatures (SSTs) and δO18 G. bulloides records indicate cooling at 8.2 ka (S1a) and ~7.8 ka (S1 interruption). Sapropelic layer S1b (7.7–6.4 ka) is characterized by rather oxic conditions; abundances of foraminiferal species tolerant to oxygen depletion are very low compared with the U. mediterranea rise. Strongly fluctuating SSTs demonstrate repeated cooling and associated dense water formation, with a major event at 7.4 ka followed by cold spells at 7.0, 6.8, and 6.5 ka. The prominent rise of the carbon preference index within the S1b layer indicates the delivery of less degraded terrestrial OM. The increase of algal biomarkers, labile OM-feeding foraminifera and eutrophic planktonic species pinpoints an enhanced in situ marine productivity, promoted by more efficient vertical convection due to repeated cold events. The associated contributions of labile marine OM along with fresher terrestrial OM inputs after ~7.7 ka imply sources alternative/additional to the north Aegean riverine borderland sources for the influx of organic matter in the south Limnos Basin, plausibly related to the inflow of highly productive Marmara/Black Sea waters.
Nastos PT, Bleta AG, Matsangouras IT. Human thermal perception related to Föhn winds due to Saharan dust outbreaks in Crete Island, Greece. Theoretical and Applied Climatology [Internet]. 2016:1 - 13. Website
Anoussis M, Katavolos A, Todorov IG. Ideals of the {F}ourier algebra, supports and harmonic operators. Math. Proc. Cambridge Philos. Soc. [Internet]. 2016;161:223–235. Website
Mina D, Sagonas K, Fragopoulou AF, Pafilis P, Skouroliakou A, Margaritis LH, Tsitsilonis OE, Valakos ED. Immune responses of a wall lizard to whole-body exposure to radiofrequency electromagnetic radiation. Int J Radiat Biol. 2016;92(3):162-8.Abstract
PURPOSE: During the last three decades, the number of devices that emit non-ionizing electromagnetic radiation (EMR) at the wireless communication spectrum has rapidly increased and possible effects on living organisms have become a major concern. The purpose of this study was to investigate the effects of radiofrequency EMR emitted by a widely used wireless communication device, namely the Digital Enhanced Communication Telephony (DECT) base, on the immune responses of the Aegean wall lizard (Podarcis erhardii). MATERIALS AND METHODS: Adult male lizards were exposed 24 h/day for 8 weeks to 1880-1900 MHz DECT base radiation at average electric field intensity of 3.2 V/m. Immune reactivity was assessed using the phytohemagglutinin (PHA) skin swelling and mixed lymphocyte reaction (MLR) tests. RESULTS: Our results revealed a noticeable suppression (approximately 45%) of inflammatory responses in EMR-exposed lizards compared to sham-exposed animals. T cell-mediated responses were marginally affected. CONCLUSION: Daily radiofrequency EMR exposure seems to affect, at least partially, the immunocompetence of the Aegean wall lizard.
Vavuranakis M, Papaioannou TG, Katsarou OA, Vrachatis DA, Sanidas EA, Siasos G, Kalogeras KI, Schizas D, Stefanadis CI, Tousoulis D. Impact of atherosclerotic plaque components and their distribution on stent deployment: An intravascular-ultrasound virtual histology observational study. Minerva Cardioangiologica [Internet]. 2016;64(5):507 - 516. Website
Papaioannou, C.D. SSPKLVJIF. Impact of different preservation treatments on lipids of the smooth clam Callista chione. International Journal of Food Science and Technology [Internet]. 2016;51:325-332. Website
Dimopoulos MA, Cheung MC, Roussel M, Liu T, Gamberi B, Kolb B, Derigs HG, Eom HS, Belhadj K, Lenain P, et al. Impact of renal impairment on outcomes with lenalidomide and dexamethasone treatment in the FIRST trial, a randomized, open-label phase 3 trial in transplant-ineligible patients with multiple myeloma. Haematologica [Internet]. 2016;101(3):363 - 370. WebsiteAbstract
Renal impairment is associated with poor prognosis in myeloma. This analysis of the pivotal phase 3 FIRST trial examined the impact of renally adapted dosing of lenalidomide and dexamethasone on outcomes of patients with different degrees of renal impairment. Transplant-ineligible patients not requiring dialysis were randomized 1:1:1 to receive continuous lenalidomide and dexamethasone until disease progression (n=535) or for 18 cycles (72 weeks; n=541), or melphalan, prednisone, and thalidomide for 12 cycles (72 weeks; n=547). Follow-up is ongoing. Patients were grouped by baseline creatinine clearance into no (≥ 80 mL/min [n=389]), mild (≥ 50 to < 80 mL/min [n=715]), moderate (≥ 30 to < 50 mL/min [n=372]), and severe impairment (< 30 mL/min [n=147]) subgroups. Continuous lenalidomide and dexamethasone therapy reduced the risk of progression or death in no, mild, and moderate renal impairment subgroups vs. melphalan, prednisone, and thalidomide therapy (HR = 0.67, 0.70, and 0.65, respectively). Overall survival benefits were observed with continuous lenalidomide and dexamethasone treatment vs.melphalan, prednisone, and thalidomide treatment in no or mild renal impairment subgroups. Renal function improved from baseline in 52.6% of lenalidomide and dexamethasone–treated patients. The safety profile of continuous lenalidomide and dexamethasone was consistent across renal subgroups, except for grade 3/4 anemia and rash, which increased with increasing severity of renal impairment. Continuous lenalidomide and dexamethasone treatment, with renally adapted lenalidomide dosing, was effective for most transplant-ineligible patients with myeloma and renal impairment. Trial registration: ClinicalTrials.gov (NCT00689936); EudraCT (2007- 004823-39). Funding: Intergroupe Francophone du Myélome and the Celgene Corporation. © 2016 Ferrata Storti Foundation.
Sagonas K, Rota IA, Tsitsilonis OE, Pafilis P, Valakos ED. Infection risk dictates immunological divergence among populations in a Mediterranean lizard. J Evol Biol. 2016;29(9):1680-8.Abstract
The ability of vertebrates to evolve different defence strategies in response to varying parasitism regimes remains poorly understood. Hosts may adopt two different strategies to defend themselves against parasites: tolerance (hosts alleviate the negative fitness consequences of parasite infection) and resistance (hosts strengthen their immune response as parasite burden increases). Both strategies are effective, but fitness has been reported to decline faster in less-tolerant individuals. Here, we assessed the number of splenocytes and the cell-mediated response (proxies for resistance) and body condition (a proxy for tolerance) in four populations of a Greek endemic lizard (Podarcis gaigeae), each exposed to different infection risks (defined as the cumulative effect of parasite burden and duration of exposure). We anticipated that populations with heavy parasite burden would enhance the efficacy of their immune response (resistance) compared to lizards deriving from parasite-poor habitats. We also predicted that populations with longer exposure to parasites would be adopted and be more tolerant. Each factor (duration of exposure and parasite burden) had a distinct effect on the immune response, and thus, our results were rather complicated. Lizards with heavy parasite burden and aperiodic exposure demonstrated resistance, whereas lizards with heavy parasite burden and chronic exposure were more tolerant. Populations with low parasite burden and minimal exposure were more resistant. Our results suggest that the development of some immunological strategies may be differentiated under different infection risks, even within the same species.
Vasilakaki S, Barbayianni E, Magrioti V, Pastukhov O, Constantinou-Kokotou V, Huwiler A, Kokotos G. Inhibitors of secreted phospholipase A2 suppress the release of PGE2 in renal mesangial cells. Bioorganic and Medicinal Chemistry. 2016;24:3029-3034.Abstract
The upregulation of PGE2 by mesangial cells has been observed under chronic inflammation condition. In the present work, renal mesangial cells were stimulated to trigger a huge increase of PGE2 synthesis and were treated in the absence or presence of known PLA2 inhibitors. A variety of synthetic inhibitors, mainly developed in our labs, which are known to selectively inhibit each of GIVA cPLA2, GVIA iPLA2, and GIIA/GV sPLA2, were used as tools in this study. Synthetic sPLA2 inhibitors, such as GK115 (an amide derivative based on the non-natural amino acid (R)-γ-norleucine) as well as GK126 and GK241 (2-oxoamides based on the natural (S)-α-amino acid leucine and valine, respectively) presented an interesting effect on the suppression of PGE2 formation.
Triantafyllou N, Armeni E, Christidi F, Rizos D, Kaparos G, Palaiologou A, Augoulea A, Alexandrou A, Zalonis I, Tzivgoulis G, et al. The intensity of menopausal symptoms is associated with episodic memory in postmenopausal women. Climacteric [Internet]. 2016;19:393-399. Website
Kamberidou I. Interacting, sharing and bonding: ‘notes of personal experience’ by nineteenth-century women travellers. Gender, Place and Culture - A Journal of Feminist Geography. 2016;23(17):381-397.Abstract
As early as the seventeenth century, women have been going from one corner of the world to the other recording their experiences and reasons for publishing. Exploring, working and residing in regions of the East considered ‘safe for dynamic men only’ (Smith 1887, Through Cyprus, Author of ‘Glimpses of Greek life and Scenery, etc’. London: Hurst and Blacket), western women interacted with the peoples of Ottoman society, enjoying their warm and generous hospitality. Their gender allowed them to study, learn and become experts in areas where men had no access: the Ottoman harems, women's daily life, social gatherings and celebrations. Western and eastern women discuss harem slavery, marriage, adultery, childbirth, abortion, divorce, religion and women's rights. In reconsulting primary sources and focusing on the writings of nineteenth-century British women in Asia Minor (Turkey), this article contributes additional evidence on women's alternative representations or less degrading gaze, while revealing a patriarchal system's domestic-social reality that was founded on the institution of slavery. In other words, it differs from other studies in spotlighting the accounts that are illustrative of the polyethnic synthesis of the Ottoman households, i.e. the discourse on the multiethnic harem slavery institution, which distinguished Ottoman society, so as to provide a bigger picture and inspire new discussions.
gender_place_and_culture.pdf
Kamberidou I. Interacting, sharing and bonding: ‘notes of personal experience’ by nineteenth-century women travellers. Gender, Place & CultureGender, Place & Culture [Internet]. 2016;23(3):381 - 397. Publisher's VersionAbstract
Alexandris S, Papadopoulos P, Sakellariou G, Steinhart M, Butt H-J, Floudas G. Interfacial Energy and Glass Temperature of Polymers Confined to Nanoporous Alumina. Macromolecules [Internet]. 2016;49(19):7400-7414. Publisher's VersionAbstract
We report on the effect of interfacial energy on the glass temperature, Tg, of several amorphous polymers with various glass temperatures and polymer/substrate interactions confined within self-ordered nanoporous alumina (AAO). The polymers studied include poly(phenylmethylsiloxane) (PMPS), poly(vinyl acetate) (PVAc), 1,4-polybutadiene (PB), oligostyrene (PS), and poly(dimethylsiloxane) (PDMS). The segmental dynamics and associated Tg’s are studied by means of dielectric spectroscopy. The interfacial energy for the polymer/substrate interface, γSL, is calculated with Young’s equation whereas the AAO membrane surface energy is obtained by measuring contact angles for several reference liquids. We find that interfacial energy plays a significant role in the segmental dynamics of polymers under confinement within AAO. There is a trend for a decreasing glass temperature relative to the bulk with increasing interfacial energy. PDMS exhibits the highest interfacial energy and the highest reduction in glass temperature within AAO. Other effects that may also contribute to changes in Tg are discussed.
Kumar S, Paiva B, Anderson KC, Durie B, Landgren O, Moreau P, Munshi N, Lonial S, Bladé J, Mateos M-V, et al. International Myeloma Working Group consensus criteria for response and minimal residual disease assessment in multiple myeloma. The Lancet Oncology [Internet]. 2016;17(8):e328 - e346. WebsiteAbstract
Treatment of multiple myeloma has substantially changed over the past decade with the introduction of several classes of new effective drugs that have greatly improved the rates and depth of response. Response criteria in multiple myeloma were developed to use serum and urine assessment of monoclonal proteins and bone marrow assessment (which is relatively insensitive). Given the high rates of complete response seen in patients with multiple myeloma with new treatment approaches, new response categories need to be defined that can identify responses that are deeper than those conventionally defined as complete response. Recent attempts have focused on the identification of residual tumour cells in the bone marrow using flow cytometry or gene sequencing. Furthermore, sensitive imaging techniques can be used to detect the presence of residual disease outside of the bone marrow. Combining these new methods, the International Myeloma Working Group has defined new response categories of minimal residual disease negativity, with or without imaging-based absence of extramedullary disease, to allow uniform reporting within and outside clinical trials. In this Review, we clarify several aspects of disease response assessment, along with endpoints for clinical trials, and highlight future directions for disease response assessments. © 2016 Elsevier Ltd
Kumar S, Paiva B, Anderson KC, Durie B, Landgren O, Moreau P, Munshi N, Lonial S, Bladé J, Mateos M-V, et al. International Myeloma Working Group consensus criteria for response and minimal residual disease assessment in multiple myeloma. The Lancet Oncology [Internet]. 2016;17(8):e328 - e346. WebsiteAbstract
Treatment of multiple myeloma has substantially changed over the past decade with the introduction of several classes of new effective drugs that have greatly improved the rates and depth of response. Response criteria in multiple myeloma were developed to use serum and urine assessment of monoclonal proteins and bone marrow assessment (which is relatively insensitive). Given the high rates of complete response seen in patients with multiple myeloma with new treatment approaches, new response categories need to be defined that can identify responses that are deeper than those conventionally defined as complete response. Recent attempts have focused on the identification of residual tumour cells in the bone marrow using flow cytometry or gene sequencing. Furthermore, sensitive imaging techniques can be used to detect the presence of residual disease outside of the bone marrow. Combining these new methods, the International Myeloma Working Group has defined new response categories of minimal residual disease negativity, with or without imaging-based absence of extramedullary disease, to allow uniform reporting within and outside clinical trials. In this Review, we clarify several aspects of disease response assessment, along with endpoints for clinical trials, and highlight future directions for disease response assessments. © 2016 Elsevier Ltd
Dimopoulos MA, Sonneveld P, Leung N, Merlini G, Ludwig H, Kastritis E, Goldschmidt H, Joshua D, Orlowski RZ, Powles R, et al. International Myeloma working group recommendations for the diagnosis and management of Myeloma-Related Renal Impairment. Journal of Clinical Oncology [Internet]. 2016;34(13):1544 - 1557. WebsiteAbstract
Purpose The aim of the International Myeloma Working Group was to develop practical recommendations for the diagnosis and management of multiple myeloma-related renal impairment (RI). Methods Recommendations were based on published data through December 2015, and were developed using the system developed by the Grading of Recommendation, Assessment, Development, and Evaluation Working Group. Recommendations All patients with myeloma at diagnosis and at disease assessment should have serum creatinine, estimated glomerular filtration rate, and electrolytes measurements as well as free light chain, if available, and urine electrophoresis of a sample from a 24-hour urine collection (grade A). The Chronic Kidney Disease Epidemiology Collaboration, preferably, or the Modification of Diet in Renal Disease formula should be used for the evaluation of estimated glomerular filtration rate in patients with stabilized serum creatinine (grade A). International Myeloma Working Group criteria for renal reversibility should be used (grade B). For themanagement of RI in patientswithmultiplemyeloma, high fluid intake is indicated along with antimyeloma therapy (grade B). The use of high-cutoff hemodialysis membranes in combination with antimyeloma therapy can be considered (grade B). Bortezomib-based regimens remain the cornerstone of the management of myeloma-related RI (grade A). High-dose dexamethasone should be administered at least for the first month of therapy (grade B). Thalidomide is effective in patients with myeloma with RI, and no dose modifications are needed (grade B). Lenalidomide is effective and safe, mainly in patients with mild to moderate RI (grade B); for patients with severe RI or on dialysis, lenalidomide should be given with closemonitoring for hematologic toxicity (grade B) with dose reduction as needed. High-dose therapy with autologous stem cell transplantation (with melphalan 100 mg/m2 to 140 mg/m2) is feasible in patients with RI (grade C). Carfilzomib can be safely administered to patients with creatinine clearance . 15 mL/min, whereas ixazomib in combination with lenalidomide and dexamethasone can be safely administered to patients with creatinine clearance . 30 mL/min (grade A). © 2016 by American Society of Clinical Oncology.
Dimopoulos MA, Sonneveld P, Leung N, Merlini G, Ludwig H, Kastritis E, Goldschmidt H, Joshua D, Orlowski RZ, Powles R, et al. International Myeloma working group recommendations for the diagnosis and management of Myeloma-Related Renal Impairment. Journal of Clinical Oncology [Internet]. 2016;34(13):1544 - 1557. WebsiteAbstract
Purpose The aim of the International Myeloma Working Group was to develop practical recommendations for the diagnosis and management of multiple myeloma-related renal impairment (RI). Methods Recommendations were based on published data through December 2015, and were developed using the system developed by the Grading of Recommendation, Assessment, Development, and Evaluation Working Group. Recommendations All patients with myeloma at diagnosis and at disease assessment should have serum creatinine, estimated glomerular filtration rate, and electrolytes measurements as well as free light chain, if available, and urine electrophoresis of a sample from a 24-hour urine collection (grade A). The Chronic Kidney Disease Epidemiology Collaboration, preferably, or the Modification of Diet in Renal Disease formula should be used for the evaluation of estimated glomerular filtration rate in patients with stabilized serum creatinine (grade A). International Myeloma Working Group criteria for renal reversibility should be used (grade B). For themanagement of RI in patientswithmultiplemyeloma, high fluid intake is indicated along with antimyeloma therapy (grade B). The use of high-cutoff hemodialysis membranes in combination with antimyeloma therapy can be considered (grade B). Bortezomib-based regimens remain the cornerstone of the management of myeloma-related RI (grade A). High-dose dexamethasone should be administered at least for the first month of therapy (grade B). Thalidomide is effective in patients with myeloma with RI, and no dose modifications are needed (grade B). Lenalidomide is effective and safe, mainly in patients with mild to moderate RI (grade B); for patients with severe RI or on dialysis, lenalidomide should be given with closemonitoring for hematologic toxicity (grade B) with dose reduction as needed. High-dose therapy with autologous stem cell transplantation (with melphalan 100 mg/m2 to 140 mg/m2) is feasible in patients with RI (grade C). Carfilzomib can be safely administered to patients with creatinine clearance . 15 mL/min, whereas ixazomib in combination with lenalidomide and dexamethasone can be safely administered to patients with creatinine clearance . 30 mL/min (grade A). © 2016 by American Society of Clinical Oncology.
Kritikou V. Interpretaciones acerca de las formas del poder en la novela Aluvión de Fuego de Óscar Cerruto. In: ΠΟΛΥΠΡΑΓΜΟΣΥΝΗ: Homenaje al Profesor Alfonso Martínez Díez. 1st ed. Madrid: Ediciones Clásicas; 2016. pp. 389-394. homenaje_amd.kritikou.formasdelpoder.aluvion_de_fuego.pdf
Arianoutsou M, Christopoulou A, Vassilakis E, Papanikolaou I, Farangitakis GP. Investigating the Role of Bedrock Geology on the Process of Post-Fire Vegetation Recovery: A Case Study from the Taygetos Mountain. In: 8th Panhellenic Conference of Ecology (HELECOS). Thessaloniki; 2016.Abstract
Fires of 2007 have consumed large areas of Black pine and Greek fir forests in Peloponnese, Euboea and Attica. Most studies that followed, focused on the natural regeneration potential or the need for reforestation. The current research aims at examining the role of geomorphology and lithology that govern the soil properties upon the post-fire vegetation recovery at the landscape level. A case study from Taygetos Mt, a large part of which was burned in 2007, is presented. Based on the interpretation of a high spatial and spectral resolution satellite image (WorldView-3, 4/2015), several GIS thematic layers have been created showing unburned and regenerated patches over various lithological types. A network of sites was selected for field sampling representing various combinations of the above. Data on vegetation cover and recovery of the main tree species were collected. Results prove the interrelationship between regeneration and species traits as well as the existence of unburned patches near the burned ones. Recovery seems to be controlled by the geology of the plots as it was found weaker in plots overlying carbonate, permeable, not easily erodible formations as compared to that observed over clastic, impermeable, erodible formations of schists, even for the same species. In conclusion, post-fire vegetation recovery at the landscape level seems to be a complex process controlled not only from species biology but also from the landscape features and its fire history.
Kenourgios D, Nader N, Dimitriou D. Islamic financial markets and global crises: Contagion or decoupling. Economic Modelling [Internet]. 2016;57:36-46. WebsiteAbstract
This paper investigates the contagion effects of the global financial crisis (GFC) and Eurozone sovereign debt crisis (ESDC) on Islamic equity and bond markets. Using a sample of Islamic stock indices from various developed and emerging markets and the global Islamic stock and bond (sukuk) indices, we explore asymmetric conditional correlation dynamics across stable and crisis periods and across the two crises. The results fail to provide strong contagion evidence between conventional and Islamic equity and bond indices, supporting the decoupling hypothesis of the Islamic securities. Our findings imply that Islamic equities and bonds may provide a cushion against risk and instability, particularly in periods of turmoil. The small number of contagion cases mostly relates to the ESDC and developed Islamic stock indices. The findings also show that the Islamic emerging stock indices in the BRICS provide the most effective international portfolio diversification benefits compared to the Islamic developed indices.
Kritikou V. La muerte en "Nino", "Leonela" y "En la ciénaga" de Onelio Jorge Cardoso. In: Nuevas perspectivas en los cuentos de Onelio Jorge Cardoso. 1st ed. Madrid: Ediciones del Orto; 2016. pp. 23-31. kritikou-muerte-ojcardoso.pdf
Achalhi, M., Munch, Ph., Cornee, J.-J., Azdimousa, A., Melinte-Dobrinescu, M., Quillévéré, F., Drinia, H., Fauquette, S., Jiménez-Moreno, G., Merzeraud, G., et al. The late Miocene Mediterranean-Atlantic connections through the North Rifian Corridor: New insights from the Boudinar and Arbaa Taourirt basins (northeastern Rif, Morocco). Palaeogeography, Palaeoclimatology, Palaeoecology [Internet]. 2016;459:131-152. Publisher's Version
Mamoucha S, Fokialakis N, Christodoulakis NS. Leaf structure and histochemistry of Ficus carica (Moraceae), the fig tree. Flora: Morphology, Distribution, Functional Ecology of Plants [Internet]. 2016;218:24 - 34. WebsiteAbstract
Heavily "armed" with trichomes, the hypostomatic leaf of Ficus carica L. is investigated with light and scanning electron microscopy. Histochemical tests were also applied to trace the secondary matabolites produced in the leaf of this well known, Mediterranean tree with the delicious fruits. Numerous idioblasts with crystals, laticifers and sized lythocysts appear within the compact mesophyll. Protective trichomes are located on both surfaces while capitate secretive hairs and stomata appear only abaxially. Stomata, concerning their magnitude, can be assembled in three size-groups in which the arrangement of their parastomatal cells differs as well. Histochemical reactions proved positive only for alkaloids within the laticifers and phenolic compounds, especially for the condensed tannins accumulated within the vacuole of the epidermal cells of this simply constructed leaf with unique features among the Mediterranean herbs. Comparison of GC-MS and LC-HRMS spectra of different extracts of the nerves and, separately, the rest of the leaf, revealed that coumarines such as umbeliferone, psoralen, bergapten and xanthotoxol are probably biosynthetically produced within the nerve area where the highly differentiated, main secretive apparatus of the leaf (laticifers) resides. That is why, these metabolites, are absent from the extracts of the undifferentiated cells derived from in vitro cultures. © 2015 Elsevier GmbH.
Mamoucha S, Christodoulakis NS. Leaf tissue arrangement, preliminary phytochemical investigation and callus induction from the medicinal hemi-parasite Osyris alba L. International Journal of Pharmacognosy and Phytochemical Research [Internet]. 2016;8(9):1437 - 1443. WebsiteAbstract
Osyris alba is a dioecious shrub used in traditional medicine for its bioactive secondary metabolites. It is used for its antiparasitic, antimicrobial and anti-bleeding properties. In the present study the leaf tissue arrangement, histochemsitry and callus formation of Osyris alba L. were investigated. Leaves (fresh and fixed) were observed by light, polarized oight and electron microscopy. Fresh stem was also observed by light microscopy. The sub-cellular localization of secondary metabolites was detected. Furthermore, in vitro production of its secondary metabolite, by using cell cultures, was also preformed. The compact leaves are amphistomatic, with a single layer of epidermal cells and contain idioblasts cells with crystals. They react positively to histochemical reagents for the major groups of secondary metabolites. In the preliminary histochemical screening, in vitro cultured cells also gave positive results. In conclusion, the medicinal nature of the plant is attributed to its phytochemical profile. Plant cell culture technologies can be used for the production of its bioactive molecules. © 2016, International Journal of Pharmacognosy and Phytochemical Research. All rights reserved.
Zagouri F, Roussou M, Kastritis E, Gavriatopoulou M, Eleutherakis-Papaiakovou E, Kanellias N, Kalapanida D, Christoulas D, Migkou M, Terpos E, et al. Lenalidomide with low- or intermediate-dose dexamethasone in patients with relapsed or refractory myeloma. Leukemia and Lymphoma [Internet]. 2016;57(8):1776 - 1780. WebsiteAbstract
Abstract: To compare the outcomes of patients with relapsed or refractory multiple myeloma (RRMM) who were treated with lenalidomide combined with high versus low dose of dexamethasone. One hundred forty consecutive relapsed or refractory multiple myeloma (RRMM) patients who received lenalidomide with dexamethasone, in two consecutive time periods, were divided into two groups: group RD (70 consecutive patients in the first period) who received lenalidomide with intermediate doses of dexamethasone and group Rd (70 consecutive patients in the more recent period) who received lenalidomide with low-dose dexamethasone. 62% and 73% of patients who received RD and Rd (p = 0.148) achieved at least a partial response, accordingly. The median OS was 20 and 41 months for the RD and the Rd group, accordingly. In the multivariate analysis, Rd was associated with improved PFS. More patients treated with RD developed grade 3&4 neutropenia and fatigue. It seems that Rd is at least as effective as RD. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
Zagouri F, Roussou M, Kastritis E, Gavriatopoulou M, Eleutherakis-Papaiakovou E, Kanellias N, Kalapanida D, Christoulas D, Migkou M, Terpos E, et al. Lenalidomide with low- or intermediate-dose dexamethasone in patients with relapsed or refractory myeloma. Leukemia and Lymphoma [Internet]. 2016;57(8):1776 - 1780. WebsiteAbstract
Abstract: To compare the outcomes of patients with relapsed or refractory multiple myeloma (RRMM) who were treated with lenalidomide combined with high versus low dose of dexamethasone. One hundred forty consecutive relapsed or refractory multiple myeloma (RRMM) patients who received lenalidomide with dexamethasone, in two consecutive time periods, were divided into two groups: group RD (70 consecutive patients in the first period) who received lenalidomide with intermediate doses of dexamethasone and group Rd (70 consecutive patients in the more recent period) who received lenalidomide with low-dose dexamethasone. 62% and 73% of patients who received RD and Rd (p = 0.148) achieved at least a partial response, accordingly. The median OS was 20 and 41 months for the RD and the Rd group, accordingly. In the multivariate analysis, Rd was associated with improved PFS. More patients treated with RD developed grade 3&4 neutropenia and fatigue. It seems that Rd is at least as effective as RD. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
Kellici TF, Ntountaniotis D, Kritsi E, Zervou M, Zoumpoulakis P, Potamitis C, Durdagi S, Salmas RE, Ergun G, Gokdemir E, et al. Leveraging NMR and X-ray data of the free ligands to build better drugs targeting angiotensin II Type 1 G-Protein coupled receptor. Current Medicinal Chemistry [Internet]. 2016;23(1):36 - 59. Website
Dimiza M, Koukousioura O, Triantaphyllou M, Dermitzakis M. Live and dead benthic foraminiferal assemblages from coastal environments of the Aegean Sea (Greece): Distribution and diversity. Revue de Micropaléontologie [Internet]. 2016;59(1):19-32. Publisher's VersionAbstract
Benthic foraminiferal composition assemblages and their temporal changes, ecological indices and foraminiferal densities are used to compare three coastal environments with different physicogeographical features in the Aegean Sea (coastal environment of Avdira–Vistonikos Gulf and Kitros–Thermaikos Gulf and open lagoonal environment of Vravron–South Evoikos Gulf). Three main foraminiferal assemblages have been recognized: a) “Assemblage A”; high degree of similarity between living and dead foraminiferal species, dominated byAmmonia beccarii, Elphidium spp. and relatively abundant and diverse miliolids, b) “Assemblage B1”; intermediate degree of similarity between live and dead assemblages, characterized by highly-abundant and well-diversified foraminiferal assemblages including the algal symbiont bearing Peneroplis pertusus together withAmmonia tepida and several small epiphytic rotaliids and miliolids, and c) “Assemblage B2”; absence of living individuals, strongly dominated by the opportunistic species A. tepida. Our results suggest a good comparison between living and dead assemblages from different coastal environments in the Aegean Sea, however the prevailing environmental conditions (vegetation cover, hydrodynamics, fresh water influx) have a strong impact on the taphonomic processes.
Christaki M, Stournaras G, Nastos P, Mamasis N. The majestic Hadrianic aqueduct of the city of Athens. Global Nest Journal [Internet]. 2016;18(3):559 - 568. Website
Fotiou D, Dimopoulos MA, Kastritis E. Managing renal complications in multiple myeloma. Expert Review of Hematology [Internet]. 2016;9(9):839 - 850. WebsiteAbstract
Introduction: About 20–40% of patients with multiple myeloma (MM) will present with some degree of renal impairment (RI) and about 25% of patients will experience RI at later disease stages. Patients with MM and RI have poorer overall survival and are at higher risk of early death. Areas covered: The mechanisms of acute renal damage in MM are covered and the issues around diagnosis and renal evaluation response are discussed. The importance of optimal supportive care is stressed and the role and effectiveness of different anti-myeloma agents covered including the role of high cut-off hemodialysis, autologous stem cell transplantation and kidney transplant. Expert commentary: Outcomes of patients with RI and rates of renal recovery have improved with the use of novel anti-myeloma agents. Bortezomib-dexamethasone backbone regimes (±third agent) are the current first choice in newly diagnosed patients. In relapsed/refractory disease additional treatment options include newer novel agents. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
Fotiou D, Dimopoulos MA, Kastritis E. Managing renal complications in multiple myeloma. Expert Review of Hematology [Internet]. 2016;9(9):839 - 850. WebsiteAbstract
Introduction: About 20–40% of patients with multiple myeloma (MM) will present with some degree of renal impairment (RI) and about 25% of patients will experience RI at later disease stages. Patients with MM and RI have poorer overall survival and are at higher risk of early death. Areas covered: The mechanisms of acute renal damage in MM are covered and the issues around diagnosis and renal evaluation response are discussed. The importance of optimal supportive care is stressed and the role and effectiveness of different anti-myeloma agents covered including the role of high cut-off hemodialysis, autologous stem cell transplantation and kidney transplant. Expert commentary: Outcomes of patients with RI and rates of renal recovery have improved with the use of novel anti-myeloma agents. Bortezomib-dexamethasone backbone regimes (±third agent) are the current first choice in newly diagnosed patients. In relapsed/refractory disease additional treatment options include newer novel agents. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
Kellici TF, Chatziathanasiadou MV, Diamantis D, Chatzikonstantinou AV, Andreadelis I, Christodoulou E, Valsami G, Mavromoustakos T, Tzakos AG. Mapping the interactions and bioactivity of quercetin—(2-hydroxypropyl)-β-cyclodextrin complex. International Journal of Pharmaceutics [Internet]. 2016;511(1):303 - 311. Website
Papaioannou TG, Protogerou AD, Vavuranakis M, Tousoulis D. Mean Arterial Pressure Estimation by a Non-Traditional Formula and Fractional Pulse Pressure. Journal of the American College of Cardiology [Internet]. 2016;68(6):668 - 669. Website
Papaioannou TG, Protogerou AD, Vrachatis D, Konstantonis G, Aissopou E, Argyris A, Nasothimiou E, Gialafos EJ, Karamanou M, Tousoulis D, et al. Mean arterial pressure values calculated using seven different methods and their associations with target organ deterioration in a single-center study of 1878 individuals. Hypertension Research [Internet]. 2016;39(9):640 - 647. Website
Fotakis, C. TTLSMTPSZDTD. Metabolic and antioxidant profiles of herbal infusions and decoctions. Food Chemistry [Internet]. 2016. Website
Almpanis E, Pantazopoulos PA, Papanikolaou N, Yannopapas V, Stefanou N. Metal-nanoparticle arrays on a magnetic garnet film for tunable plasmon-enhnaced Faraday rotation. Journal of the Optical Society of America B. 2016;33(12):2609-2616.Abstract
We developed an extension of the layer-multiple-scattering method to photonic crystals comprising homogeneous layers of magneto-optical materials. The applicability of the method is demonstrated on a specific architecture of a magnetic garnet thin film coated with a square array of silver nanodisks, supported by a silica substrate. It is shown that enhanced Faraday rotation, driven by hybrid particle plasmon-film quasi-guided collective modes, can be achieved within selected regions of frequency, which can be tuned by properly choosing the geometric and material parameters involved. The results are analyzed in conjunction with numerical simulations by the finite-element method and a consistent interpretation of the underlying physics is provided. Our extended layer-multiple-scattering computational methodology provides a versatile framework for fast and accurate full electrodynamic calculations of magneto-optical structures, enabling physical insight.
Stergiou GS, Parati G, Vlachopoulos C, Achimastos A, Andreadis E, Asmar R, Avolio A, Benetos A, Bilo G, Boubouchairopoulou N, et al. Methodology and technology for peripheral and central blood pressure and blood pressure variability measurement: Current status and future directions - Position statement of the European Society of Hypertension Working Group on blood pressure monitoring a. Journal of Hypertension [Internet]. 2016;34(9):1665 - 1677. Website
Dalezios NR, Nastos PT. Milestones of the diachronic evolution of meteorology. International Journal of Global Environmental Issues [Internet]. 2016;15(1-2):49 - 69. Website
Nastos PT, Polychroni ID. Modeling and in situ measurements of biometeorological conditions in microenvironments within the Athens University Campus, Greece. International Journal of Biometeorology [Internet]. 2016;60(10):1463 - 1479. Website
Vallatou Μ, Mitsopoulos Ι, Mallinis G, Vassilakis Ε, Arianoutsou Μ. Modeling Spatial Fire Risk and Exposure to Important Habitats in Cephalonia Island. In: 8th Panhellenic Conference of Ecology (HELECOS). Thessaloniki; 2016.Abstract
Within this study we introducea framework for assessing spatial fire risk and exposure to three important habitat types in Cephalonia island, Greece.Existing maps were used for plot allocation in orderto measure several fuel parameters in representative natural fuel complexes for site-specific fuel models development, as well as for collecting training and validation points for satellite data classification. The spatial extent of the fuel types and the canopy cover were delineated using a Landsat 8 OLI image acquired on 23-7-2015and the Support Vector Machines-(SVMs) machine learning algorithm. Subsequently, The Minimum Travel Time (MTT) algorithm, as it is embedded in FlamMap spatial fire simulation software, was applied in order to assess critical fire behavior parameters and exposure of Cephalonia's habitats under three different meteorological and fuel moisture scenarios. The outputs of this study may be used as an application of quantitative and probabilistic risk assessment for habitats conservation planning, prioritization and management of high value natural and cultural resources.
Hetem DJ, Derde LPG, Empel J, Mroczkowska A, Orczykowska-Kotyna M, Kozińska A, Hryniewicz W, Goossens H, Bonten MJM. Molecular epidemiology of MRSA in 13 ICUs from eight European countries. J Antimicrob Chemother. 2016;71(1):45-52.Abstract
OBJECTIVES: The European epidemiology of MRSA is changing with the emergence of community-associated MRSA (CA-MRSA) and livestock-associated MRSA (LA-MRSA). In this study, we investigated the molecular epidemiology of MRSA during 2 years in 13 ICUs in France, Greece, Italy, Latvia, Luxemburg, Portugal, Slovenia and Spain. METHODS: Surveillance cultures for MRSA from nose and wounds were obtained on admission and twice weekly from all patients admitted to an ICU for ≥3 days. The first MRSA isolate per patient was genotyped in a central laboratory by MLST, spa typing, agr typing and SCCmec (sub)typing. Risk factors for patients with an unknown history of MRSA colonization were identified. RESULTS: Overall, 14 390 ICU patients were screened, of whom 8519 stayed in an ICU for ≥3 days. Overall MRSA admission prevalence was 3.9% and ranged from 1.0% to 7.0% for individual ICUs. Overall MRSA acquisition rate was 2.5/1000 patient days at risk and ranged from 0.2 to 8/1000 patient days at risk per ICU. In total, 557 putative MRSA isolates were submitted to the central laboratory for typing, of which 511 (92%) were confirmed as MRSA. Each country had a distinct epidemiology, with ST8-IVc (UK-EMRSA-2/-6, USA500) being most prevalent, especially in France and Spain, and detected in ICUs in five of eight countries. Seventeen (3%) and three (<1%) isolates were categorized as CA-MRSA and LA-MRSA, respectively. Risk factors for MRSA carriage on ICU admission were age >70 years and hospitalization within 1 year prior to ICU admission. CONCLUSIONS: The molecular epidemiology of MRSA in 13 European ICUs in eight countries was homogeneous within, but heterogeneous between, countries. CA-MRSA and LA-MRSA genotypes and Panton-Valentine leucocidin-producing isolates were detected sporadically.
Tserkezis C, Stefanou N, Wubs M, Mørtensen NA. Molecular fluorescence enhancement in plasmonic environments: Exploring the role of nonlocal effects. Nanoscale. 2016;8(40):17532-17541.Abstract
Molecular spontaneous emission and fluorescence depend strongly on the emitter local environment. Plasmonic nanoparticles provide excellent templates for tailoring fluorophore emission, as they exhibit potential for both fluorescence enhancement and quenching, depending on emitter positioning in the nanoparticle vicinity. Here we explore the influence of hitherto disregarded nonclassical effects on the description of emitter–plasmon hybrids, focusing on the roles of the metal nonlocal response and especially size-dependent plasmon damping. Through extensive modelling of metallic nanospheres and nanoshells coupled to dipole emitters, we show that within a purely classical description a remarkable fluorescence enhancement can be achieved. However, once departing from the local-response approximation, and particularly by implementing the recent generalised nonlocal optical response theory, which provides a more complete physical description combining electron convection and diffusion, we show that not only are fluorescence rates dramatically reduced compared to the predictions of the local description and the common hydrodynamic Drude model, but the optimum emitter–nanoparticle distance is also strongly affected. In this respect, experimental measurements of fluorescence, the theoretical description of which requires a precise concurrent evaluation of far- and near-field properties of the system, constitute a novel, more sensitive probe for assessing the validity of state-of-the-art nonclassical theories.
Papassotiriou G-P, Kastritis E, Gkotzamanidou M, Christoulas D, Eleutherakis-Papaiakovou E, Migkou M, Gavriatopoulou M, Roussou M, Margeli A, Papassotiriou I, et al. Neutrophil Gelatinase-Associated Lipocalin and Cystatin C Are Sensitive Markers of Renal Injury in Patients with Multiple Myeloma. Clinical Lymphoma, Myeloma and Leukemia [Internet]. 2016;16(1):29 - 35. WebsiteAbstract
Background Renal impairment is a common complication of patients with multiple myeloma (MM). We aimed to evaluate the clinical significance of 2 newly discovered biomarkers of renal injury, cystatin C (CysC), a protein reflecting glomerular filtration rate, and neutrophil gelatinase-associated lipocalin (NGAL), a protein reflecting tubular injuries. Patients and Methods We studied 64 patients with newly diagnosed myeloma: 16 with asymptomatic (smoldering) MM and 48 with symptomatic myeloma; 8 patients with monoclonal gammopathy of undetermined significance (MGUS); and 20 healthy control subjects. Along with common blood and urine chemistry determinations, measurements of CysC, NGAL, β2-microglobulin, high-sensitivity C-reactive protein, and interleukin 6 were performed. Results We found that only patients with symptomatic MM had increased levels of CysC compared to controls (P <.01); that serum NGAL levels were elevated in all patients compared to controls P <.001; that NGAL strongly correlated with both estimation of glomerular filtration rate (EGFR) (CysC) and EGFR (Modification of Diet in Renal Disease [MDRD] formula) (r = 0.616, P <.0001; and r = -0.371, P <.01, respectively); that CysC showed strong correlation with EGFR (r = -0.782, P <.001) and with the International Scoring System (ISS) (more pronounced in patients with ISS-3); and that receiver operating characteristic curve analysis showed that NGAL values of > 50.5 μg/L have a 80.8% sensitivity and 86.4% specificity for EGFR < 60 mL/min (area under the curve = 0.764). Conclusion These findings suggest that both NGAL and CysC are very sensitive markers that reflect renal impairment in newly diagnosed patients with MM. The high levels of NGAL in asymptomatic patients and in MGUS patients support the hypothesis of the presence of renal damage in these patients early in the course of their disease and may reveal NGAL to be an early marker that predicts the presence of renal impairment in MM. © 2016 Elsevier Inc.
Foscolos A-S, Papanastasiou I, Foscolos GB, Tsotinis A, Kellici TF, Mavromoustakos T, Taylor MC, Kelly JM. New hydrazones of 5-nitro-2-furaldehyde with adamantanealkanohydrazides: Synthesis and: In vitro trypanocidal activity. MedChemComm [Internet]. 2016;7(6):1229 - 1236. Website
Kontakiotis, G., Karakitsios, V., Mortyn, P.G., Antonarakou, A., Drinia, H., Anastasakis, G., Agiadi, K., Kafousia, N., De Rafelis, M. New insights into the early Pliocene hydrographic dynamics and their relationship to the climatic evolution of the Mediterranean Sea. Palaeogeography, Palaeoclimatology, Palaeoecology [Internet]. 2016;459:348-364. Publisher's Version
Offers by Greek FL learners: A cross-sectional developmental study
Offers by Greek FL learners: A cross-sectional developmental study. Pragmatics [Internet]. 2016;26(4):531-562. Publisher's Version offers_by_greek_fl_learners.pdf
Mertzimekis TJ, Stamou K, Psaltis A. An online database of nuclear electromagnetic moments. Nucl. Instrum. Meth. Phys. Res. A. 2016;807:56–60.Abstract
Abstract Measurements of nuclear magnetic dipole and electric quadrupole moments are considered quite important for the understanding of nuclear structure both near and far from the valley of stability. The recent advent of radioactive beams has resulted in a plethora of new, continuously flowing, experimental data on nuclear structure – including nuclear moments – which hinders the information management. A new, dedicated, public and user friendly online database (http://magneticmoments.info) has been created comprising experimental data of nuclear electromagnetic moments. The present database supersedes existing printed compilations, including also non-evaluated series of data and relevant meta-data, while putting strong emphasis on bimonthly updates. The scope, features and extensions of the database are reported.
Bamias A, Tsantoulis P, Zilli T, Papatsoris A, Caparrotti F, Kyratsas C, Tzannis K, Stravodimos K, Chrisofos M, Wirth GJ, et al. Outcome of patients with nonmetastatic muscle-invasive bladder cancer not undergoing cystectomy after treatment with noncisplatin-based chemotherapy and/or radiotherapy: a retrospective analysis. Cancer Medicine [Internet]. 2016;5(6):1098 - 1107. WebsiteAbstract
Transurethral resection of bladder tumor (TURBT), radiotherapy, chemotherapy, or combinations can be used in patients with muscle-invasive bladder cancer (MIBC) not undergoing cystectomy. Nevertheless, unfitness for cystectomy is frequently associated with unfitness for other therapeutic modalities. We report the outcome of patients with MIBC who did not undergo cystectomy and did not receive cisplatin-based chemotherapy. Selection criteria for the study were nonmetastatic MIBC, no cystectomy, no cisplatin-based chemotherapy. Chemotherapy and/or radiotherapy should have been used aside from TURBT. Forty-nine patients (median age 79), managed between April 2001 and January 2012, were included in this analysis. Median Charlson Comorbidity Index was 5, while 76% were unfit for cisplatin. Treatment included radiotherapy (n = 7), carboplatin-based chemotherapy (n = 25), carboplatin-based chemotherapy followed by radiotherapy (n = 10), and radiochemotherapy (n = 7). Five-year event-free rate was 26% (standard error [SE] = 7) for overall survival, 23% (SE = 7) for progression-free survival, and 30 (SE = 8) for cancer-specific survival (CSS). Patients who were treated with combination of radiotherapy and chemotherapy had significantly longer CSS compared to those treated with radiotherapy or chemotherapy only (5-year CSS rate: 16% [SE 8] vs. 63% [SE 15], P = 0.053). Unfit-for-cystectomy patients frequently receive suboptimal nonsurgical treatment. Their outcome was poor. Combining chemotherapy with radiotherapy produced better outcomes and should be prospectively evaluated. © 2016 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
Bamias A, Tsantoulis P, Zilli T, Papatsoris A, Caparrotti F, Kyratsas C, Tzannis K, Stravodimos K, Chrisofos M, Wirth GJ, et al. Outcome of patients with nonmetastatic muscle-invasive bladder cancer not undergoing cystectomy after treatment with noncisplatin-based chemotherapy and/or radiotherapy: a retrospective analysis. Cancer Medicine [Internet]. 2016;5(6):1098 - 1107. WebsiteAbstract
Transurethral resection of bladder tumor (TURBT), radiotherapy, chemotherapy, or combinations can be used in patients with muscle-invasive bladder cancer (MIBC) not undergoing cystectomy. Nevertheless, unfitness for cystectomy is frequently associated with unfitness for other therapeutic modalities. We report the outcome of patients with MIBC who did not undergo cystectomy and did not receive cisplatin-based chemotherapy. Selection criteria for the study were nonmetastatic MIBC, no cystectomy, no cisplatin-based chemotherapy. Chemotherapy and/or radiotherapy should have been used aside from TURBT. Forty-nine patients (median age 79), managed between April 2001 and January 2012, were included in this analysis. Median Charlson Comorbidity Index was 5, while 76% were unfit for cisplatin. Treatment included radiotherapy (n = 7), carboplatin-based chemotherapy (n = 25), carboplatin-based chemotherapy followed by radiotherapy (n = 10), and radiochemotherapy (n = 7). Five-year event-free rate was 26% (standard error [SE] = 7) for overall survival, 23% (SE = 7) for progression-free survival, and 30 (SE = 8) for cancer-specific survival (CSS). Patients who were treated with combination of radiotherapy and chemotherapy had significantly longer CSS compared to those treated with radiotherapy or chemotherapy only (5-year CSS rate: 16% [SE 8] vs. 63% [SE 15], P = 0.053). Unfit-for-cystectomy patients frequently receive suboptimal nonsurgical treatment. Their outcome was poor. Combining chemotherapy with radiotherapy produced better outcomes and should be prospectively evaluated. © 2016 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
San-Miguel JF, Hungria VTM, Yoon S-S, Beksac M, Dimopoulos MA, Elghandour A, Jedrzejczak WW, Günther A, Nakorn TN, Siritanaratkul N, et al. Overall survival of patients with relapsed multiple myeloma treated with panobinostat or placebo plus bortezomib and dexamethasone (the PANORAMA 1 trial): a randomised, placebo-controlled, phase 3 trial. The Lancet Haematology [Internet]. 2016;3(11):e506 - e515. WebsiteAbstract
Background Panobinostat plus bortezomib and dexamethasone significantly increased median progression-free survival compared with placebo plus bortezomib and dexamethasone in the phase 3 PANORAMA 1 trial. Here, we present the final overall survival analysis for this trial. Methods PANORAMA 1 is a randomised, placebo-controlled, double-blind, phase 3 trial of patients with relapsed or relapsed and refractory multiple myeloma with one to three previous treatments. Patients were randomly assigned (1:1) to receive panobinostat (20 mg orally) or placebo, with bortezomib (1·3 mg/m2 intravenously) and dexamethasone (20 mg orally), over two distinct treatment phases. In treatment phase 1 (eight 3-week cycles), patients received: panobinostat or placebo on days 1, 3, 5, 8, 10, and 12; bortezomib on days 1, 4, 8, and 11; and dexamethasone on days 1, 2, 4, 5, 8, 9, 11, and 12. During treatment phase 2 (four 6-week cycles with a 2 weeks on, 1 week off schedule), panobinostat or placebo was given three times a week, bortezomib was administered once a week, and dexamethasone was given on the days of and following bortezomib administration. The primary endpoint was progression-free survival; overall survival was a key secondary endpoint. This study is registered at ClinicalTrials.gov, NCT01023308. Findings Between Jan 21, 2010, and Feb 29, 2012, 768 patients were enrolled into the study and randomly assigned to receive either panobinostat (n=387) or placebo (n=381), plus bortezomib and dexamethasone. At data cutoff (June 29, 2015), 415 patients had died. Median overall survival was 40·3 months (95% CI 35·0–44·8) in those who received panobinostat, bortezomib, and dexamethasone versus 35·8 months (29·0–40·6) in those who received placebo, bortezomib, and dexamethasone (hazard ratio [HR] 0·94, 95% CI 0·78–1·14; p=0·54). Of patients who had received at least two previous regimens including bortezomib and an immunomodulatory drug, median overall survival was 25·5 months (95% CI 19·6–34·3) in 73 patients who received panobinostat, bortezomib, and dexamethasone versus 19·5 months (14·1–32·5) in 74 who received placebo (HR 1·01, 95% CI 0·68–1·50). Interpretation The overall survival benefit with panobinostat over placebo with bortezomib and dexamethasone was modest. However, optimisation of the regimen could potentially prolong treatment duration and improve patients' outcomes, although further trials will be required to confirm this. Funding Novartis Pharmaceuticals. © 2016 Elsevier Ltd
San-Miguel JF, Hungria VTM, Yoon S-S, Beksac M, Dimopoulos MA, Elghandour A, Jedrzejczak WW, Günther A, Nakorn TN, Siritanaratkul N, et al. Overall survival of patients with relapsed multiple myeloma treated with panobinostat or placebo plus bortezomib and dexamethasone (the PANORAMA 1 trial): a randomised, placebo-controlled, phase 3 trial. The Lancet Haematology [Internet]. 2016;3(11):e506 - e515. WebsiteAbstract
Background Panobinostat plus bortezomib and dexamethasone significantly increased median progression-free survival compared with placebo plus bortezomib and dexamethasone in the phase 3 PANORAMA 1 trial. Here, we present the final overall survival analysis for this trial. Methods PANORAMA 1 is a randomised, placebo-controlled, double-blind, phase 3 trial of patients with relapsed or relapsed and refractory multiple myeloma with one to three previous treatments. Patients were randomly assigned (1:1) to receive panobinostat (20 mg orally) or placebo, with bortezomib (1·3 mg/m2 intravenously) and dexamethasone (20 mg orally), over two distinct treatment phases. In treatment phase 1 (eight 3-week cycles), patients received: panobinostat or placebo on days 1, 3, 5, 8, 10, and 12; bortezomib on days 1, 4, 8, and 11; and dexamethasone on days 1, 2, 4, 5, 8, 9, 11, and 12. During treatment phase 2 (four 6-week cycles with a 2 weeks on, 1 week off schedule), panobinostat or placebo was given three times a week, bortezomib was administered once a week, and dexamethasone was given on the days of and following bortezomib administration. The primary endpoint was progression-free survival; overall survival was a key secondary endpoint. This study is registered at ClinicalTrials.gov, NCT01023308. Findings Between Jan 21, 2010, and Feb 29, 2012, 768 patients were enrolled into the study and randomly assigned to receive either panobinostat (n=387) or placebo (n=381), plus bortezomib and dexamethasone. At data cutoff (June 29, 2015), 415 patients had died. Median overall survival was 40·3 months (95% CI 35·0–44·8) in those who received panobinostat, bortezomib, and dexamethasone versus 35·8 months (29·0–40·6) in those who received placebo, bortezomib, and dexamethasone (hazard ratio [HR] 0·94, 95% CI 0·78–1·14; p=0·54). Of patients who had received at least two previous regimens including bortezomib and an immunomodulatory drug, median overall survival was 25·5 months (95% CI 19·6–34·3) in 73 patients who received panobinostat, bortezomib, and dexamethasone versus 19·5 months (14·1–32·5) in 74 who received placebo (HR 1·01, 95% CI 0·68–1·50). Interpretation The overall survival benefit with panobinostat over placebo with bortezomib and dexamethasone was modest. However, optimisation of the regimen could potentially prolong treatment duration and improve patients' outcomes, although further trials will be required to confirm this. Funding Novartis Pharmaceuticals. © 2016 Elsevier Ltd
Hassinen S, Balis DS, Bauer H, Begoin M, Delcloo A, Eleftheratos K, Gimeno Garcia S, Granville J, Grossi M, Hao N, et al. Overview of the O3M SAF GOME-2 operational atmospheric composition and UV radiation data products and data availability. Atmospheric Measurement Techniques [Internet]. 2016;9:383-407. Publisher's Version a27_amt_2016.pdf
Kokotis P, Schmelz M, Kostouros E, Karandreas N, Dimopoulos M-A. Oxaliplatin-Induced Neuropathy: A Long-Term Clinical and Neurophysiologic Follow-Up Study. Clinical Colorectal Cancer [Internet]. 2016;15(3):e133 - e140. WebsiteAbstract
Micro-Abstract Acute oxaliplatin neurotoxicity and chronic sensory cumulative neuropathy were investigated in a long-term study of 31 consecutive patients with advanced colorectal cancer. Our results improve the knowledge of acute neurotoxicity and support the finding of the persistence of the sensory nerve deficits for years after the cessation of oxaliplatin therapy. © 2016 Elsevier Inc.
Kokotis P, Schmelz M, Kostouros E, Karandreas N, Dimopoulos M-A. Oxaliplatin-Induced Neuropathy: A Long-Term Clinical and Neurophysiologic Follow-Up Study. Clinical Colorectal Cancer [Internet]. 2016;15(3):e133 - e140. WebsiteAbstract
Micro-Abstract Acute oxaliplatin neurotoxicity and chronic sensory cumulative neuropathy were investigated in a long-term study of 31 consecutive patients with advanced colorectal cancer. Our results improve the knowledge of acute neurotoxicity and support the finding of the persistence of the sensory nerve deficits for years after the cessation of oxaliplatin therapy. © 2016 Elsevier Inc.
Πασιάς Γεώργιος, Φλουρής Γεώργιος, Φωτεινός Δημήτριος.

Παιδαγωγική και Εκπαίδευση

. 2nd ed. Athens, Greece: Γρηγόρης; 2016 pp. 704. Publisher's VersionAbstract
Ποιες είναι οι απαρχές των εκπαιδευτικών συστημάτων; Ποιες αρχές καθόρισαν τις «πειθαρχίες» και τη «γραμματική του σχολείου»; Πως διαγράφονται οι σχέσεις «εξουσίας-γνώσης» στο χώρο της εκπαίδευσης; Ποιες ιδέες επηρέασαν και διαμόρφωσαν τον παιδαγωγικό «λόγο» και τις εκπαιδευτικές «πρακτικές»; Ποιος είναι ο ρόλος της εκπαίδευσης στις σύγχρονες «οικονομίες και κοινωνίες της γνώσης»; Πώς καθορίζεται το σύγχρονο πλαίσιο των «ικανοτήτων» των μαθητών και των «προσόντων» των εκπαιδευτικών; Ποιοι είναι οι σύγχρονοι «λόγοι» και οι «πρακτικές» που χαρακτηρίζουν το σχολείο ως «οργανισμό και ως κοινότητα μάθησης»; Τα παραπάνω είναι μερικά από τα βασικά ερωτήματα που διατρέχουν τα κεφάλαια του παρόντος βιβλίου. Σκοπός των συγγραφέων είναι να αναλύσουν τη μετάβαση από την αρχαιολογία της εκπαίδευσης στη γενεαλογία του εκπαιδευτικού θεσμού. Στο βιβλίο παρουσιάζονται αναλυτικά θεωρήσεις και πολιτικές που επηρέασαν τη διαμόρφωση του παιδαγωγικού «λόγου» και των εκπαιδευτικών πρακτικών κατά τη διάρκεια του 19ου και του 20ου αιώνα. Έμφαση δίδεται στην ανάλυση των σχέσεων «εξουσίας-γνώσης» στο χώρο της εκπαίδευσης, και στις σχέσεις μεταξύ του εκπαιδευτικού «λόγου» και των κοινωνικών πρακτικών. Εξετάζονται οι επιδράσεις της «παγκοσμιοποίησης» και της «κοινωνίας της γνώσης» στον εκπαιδευτικό θεσμό. Αναλύονται οι σύγχρονες «πολιτικές της γνώσης» που συνδέονται με νέες θεωρίες και διαδικασίες μάθησης, με τη μετάβαση από το γνωσιοκεντρικό στο «ικανοκεντρικό» μοντέλο μάθησης, με τον μεταβαλλόμενο ρόλο και τις αλλαγές στα προσόντα των εκπαιδευτικών, με τον μετασχηματισμό του σχολείου σε «οργανισμό και σε κοινότητα μάθησης», με τη μετάβαση από τις «πειθαρχικές κοινωνίες» στις «κοινωνίες ελέγχου» και την προοπτική μιας ολοκληρωτικά παιδαγωγούμενης κοινωνίας. πάνω είναι μερικά από τα βασικά ερωτήματα που διατρέχουν τα κεφάλαια του παρόντος βιβλίου. Σκοπός των συγγραφέων είναι να αναλύσουν τη μετάβαση από την αρχαιολογία της εκπαίδευσης στη γενεαλογία του εκπαιδευτικού θεσμού. Στο βιβλίο παρουσιάζονται αναλυτικά θεωρήσεις και πολιτικές που επηρέασαν τη διαμόρφωση του παιδαγωγικού ≪λόγου≫ και των εκπαιδευτικών πρακτικών κατά τη διάρκεια του 19ου και του 20ου αιώνα. Έμφαση δίδεται στην ανάλυση των σχέσεων ≪εξουσίας-γνώσης≫ στο χώρο της εκπαίδευσης, και στις σχέσεις μεταξύ του εκπαιδευτικού ≪λόγου≫ και των κοινωνικών πρακτικών. Εξετάζονται οι επιδράσεις της ≪παγκοσμιοποίησης≫ και της ≪κοινωνίας της γνώσης≫ στον εκπαιδευτικό θεσμό. Αναλύονται οι σύγχρονες ≪πολιτικές της γνώσης≫ που συνδέονται με νέες θεωρίες και διαδικασίες μάθησης, με τη μετάβαση από το γνωσιοκεντρικό στο ≪ικανοκεντρικό≫ μοντέλο μάθησης, με τον μεταβαλλόμενο ρόλο και τις αλλαγές στα προσόντα των εκπαιδευτικών, με τον μετασχηματισμό του σχολείου σε ≪οργανισμό και σε κοινότητα μάθησης≫, με τη μετάβαση από τις ≪πειθαρχικές κοινωνίες≫ στις ≪κοινωνίες ελέγχου≫ και την προοπτική μιας ολοκληρωτικά παιδαγωγούμενης κοινωνίας. - See more at: http://www.grigorisbooks.gr/product/1718/%CF%80%CE%B1%CE%B9%CE%B4%CE%B1%CE%B3%CF%89%CE%B3%CE%B9%CE%BA%CE%AE-%CE%BA%CE%B1%CE%B9-%CE%B5%CE%BA%CF%80%CE%B1%CE%AF%CE%B4%CE%B5%CF%85%CF%83%CE%B7#sthash.1NcC0VDg.dpuf Ποιες είναι οι απαρχές των εκπαιδευτικών συστημάτων; Ποιες αρχές καθόρισαν τις ≪πειθαρχίες≫ και τη ≪γραμματική του σχολείου≫; Πως διαγράφονται οι σχέσεις ≪εξουσίας-γνώσης≫ στο χώρο της εκπαίδευσης; Ποιες ιδέες επηρέασαν και διαμόρφωσαν τον παιδαγωγικό ≪λόγο≫ και τις εκπαιδευτικές ≪πρακτικές≫; Ποιος είναι ο ρόλος της εκπαίδευσης στις σύγχρονες ≪οικονομίες και κοινωνίες της γνώσης≫; Πώς καθορίζεται το σύγχρονο πλαίσιο των ≪ικανοτήτων≫ των μαθητών και των ≪προσόντων≫ των εκπαιδευτικών; Ποιοι είναι οι σύγχρονοι ≪λόγοι≫ και οι ≪πρακτικές≫ που χαρακτηρίζουν το σχολείο ως ≪οργανισμό και ως κοινότητα μάθησης≫;  Τα παραπάνω είναι μερικά από τα βασικά ερωτήματα που διατρέχουν τα κεφάλαια του παρόντος βιβλίου. Σκοπός των συγγραφέων είναι να αναλύσουν τη μετάβαση από την αρχαιολογία της εκπαίδευσης στη γενεαλογία του εκπαιδευτικού θεσμού. Στο βιβλίο παρουσιάζονται αναλυτικά θεωρήσεις και πολιτικές που επηρέασαν τη διαμόρφωση του παιδαγωγικού ≪λόγου≫ και των εκπαιδευτικών πρακτικών κατά τη διάρκεια του 19ου και του 20ου αιώνα. Έμφαση δίδεται στην ανάλυση των σχέσεων ≪εξουσίας-γνώσης≫ στο χώρο της εκπαίδευσης, και στις σχέσεις μεταξύ του εκπαιδευτικού ≪λόγου≫ και των κοινωνικών πρακτικών. Εξετάζονται οι επιδράσεις της ≪παγκοσμιοποίησης≫ και της ≪κοινωνίας της γνώσης≫ στον εκπαιδευτικό θεσμό. Αναλύονται οι σύγχρονες ≪πολιτικές της γνώσης≫ που συνδέονται με νέες θεωρίες και διαδικασίες μάθησης, με τη μετάβαση από το γνωσιοκεντρικό στο ≪ικανοκεντρικό≫ μοντέλο μάθησης, με τον μεταβαλλόμενο ρόλο και τις αλλαγές στα προσόντα των εκπαιδευτικών, με τον μετασχηματισμό του σχολείου σε ≪οργανισμό και σε κοινότητα μάθησης≫, με τη μετάβαση από τις ≪πειθαρχικές κοινωνίες≫ στις ≪κοινωνίες ελέγχου≫ και την προοπτική μιας ολοκληρωτικά παιδαγωγούμενης κοινωνίας. - See more at: http://www.grigorisbooks.gr/product/1718/%CF%80%CE%B1%CE%B9%CE%B4%CE%B1%CE%B3%CF%89%CE%B3%CE%B9%CE%BA%CE%AE-%CE%BA%CE%B1%CE%B9-%CE%B5%CE%BA%CF%80%CE%B1%CE%AF%CE%B4%CE%B5%CF%85%CF%83%CE%B7#sthash.1NcC0VDg.dpuf
Richardson PG, Hungria VTM, Yoon S-S, Beksac M, Dimopoulos MA, Elghandour A, Jedrzejczak WW, Guenther A, Na Nakorn T, Siritanaratkul N, et al. Panobinostat plus bortezomib and dexamethasone in previously treated multiple myeloma: Outcomes by prior treatment. Blood [Internet]. 2016;127(6):713 - 721. WebsiteAbstract
Panobinostat is a potent pan-deacetylase inhibitor that affects the growth and survival of multiple myeloma (MM) cells through alteration of epigenetic mechanisms and protein metabolism. Panobinostat plus bortezomib and dexamethasone (PAN-BTZ-Dex) led to a significant increase in progression-free survival (PFS) vs placebo plus bortezomib and dexamethasone (Pbo-BTZ-Dex) in patients with relapsed or relapsed and refractoryMMin the phase 3PANORAMA1 trial. This subgroup analysis evaluated outcomes in patients in the PANORAMA 1 trial based on prior treatment: A prior immunomodulatory drug (IMiD; n 5 485), prior bortezomib plus an IMiD (n 5 193), and ≥2 prior regimens including bortezomib and an IMiD (n5147). Median PFS with PAN-BTZ-Dex vs Pbo-BTZ-Dex across subgroups was as follows: prior IMiD (12.3 vs 7.4 months; hazard ratio [HR], 0.54; 95% confidence interval [CI], 0.43-0.68), prior bortezomib plus IMiD (10.6 vs 5.8 months; HR, 0.52;95%CI, 0.36-0.76),and ≥2 prior regimens including bortezomib and an IMiD (12.5 vs 4.7 months; HR, 0.47; 95% CI, 0.31-0.72). Common grade 3/4 adverse events and laboratory abnormalities in patients who received PAN-BTZ-Dex across the prior treatment groups included thrombocytopenia, lymphopenia, neutropenia, diarrhea, and asthenia/ fatigue. Incidence of on-treatment deaths among patients who received prior bortezomib and an IMiD (regardless of number of prior regimens) was similar between treatment arms. This analysis demonstrated a clear PFS benefit of 7.8 months with PAN-BTZ-Dex among patients who received ‡2 prior regimens including bortezomib and an IMiD, a population with limited treatment options and poorer prognosis. This trial was registered at www.clinicaltrials.gov as #NCT01023308. © 2016 by The American Society of Hematology.
Richardson PG, Hungria VTM, Yoon S-S, Beksac M, Dimopoulos MA, Elghandour A, Jedrzejczak WW, Guenther A, Na Nakorn T, Siritanaratkul N, et al. Panobinostat plus bortezomib and dexamethasone in previously treated multiple myeloma: Outcomes by prior treatment. Blood [Internet]. 2016;127(6):713 - 721. WebsiteAbstract
Panobinostat is a potent pan-deacetylase inhibitor that affects the growth and survival of multiple myeloma (MM) cells through alteration of epigenetic mechanisms and protein metabolism. Panobinostat plus bortezomib and dexamethasone (PAN-BTZ-Dex) led to a significant increase in progression-free survival (PFS) vs placebo plus bortezomib and dexamethasone (Pbo-BTZ-Dex) in patients with relapsed or relapsed and refractoryMMin the phase 3PANORAMA1 trial. This subgroup analysis evaluated outcomes in patients in the PANORAMA 1 trial based on prior treatment: A prior immunomodulatory drug (IMiD; n 5 485), prior bortezomib plus an IMiD (n 5 193), and ≥2 prior regimens including bortezomib and an IMiD (n5147). Median PFS with PAN-BTZ-Dex vs Pbo-BTZ-Dex across subgroups was as follows: prior IMiD (12.3 vs 7.4 months; hazard ratio [HR], 0.54; 95% confidence interval [CI], 0.43-0.68), prior bortezomib plus IMiD (10.6 vs 5.8 months; HR, 0.52;95%CI, 0.36-0.76),and ≥2 prior regimens including bortezomib and an IMiD (12.5 vs 4.7 months; HR, 0.47; 95% CI, 0.31-0.72). Common grade 3/4 adverse events and laboratory abnormalities in patients who received PAN-BTZ-Dex across the prior treatment groups included thrombocytopenia, lymphopenia, neutropenia, diarrhea, and asthenia/ fatigue. Incidence of on-treatment deaths among patients who received prior bortezomib and an IMiD (regardless of number of prior regimens) was similar between treatment arms. This analysis demonstrated a clear PFS benefit of 7.8 months with PAN-BTZ-Dex among patients who received ‡2 prior regimens including bortezomib and an IMiD, a population with limited treatment options and poorer prognosis. This trial was registered at www.clinicaltrials.gov as #NCT01023308. © 2016 by The American Society of Hematology.
Καταπότη Δέσποινα, Βαβουρανάκης Γιώργος. Parthenon 2.0. In: Πετροπούλου Κρίστη, Ραμαντιέ Τιερί Αστικές γεωγραφίες: Τοπία και καθημερινές διαδρομές. Αθήνα: Εκδόσεις Καππόν; 2016. pp. 196-207.
Thodi G, Schulpis KH, Hatzidaki M, Molou E, Triantafylli O, Dotsikas Y, Loukas YL. Partial biotinidase deficiency: Identification of a single novel mutation (p.H314R) in a Greek newborn. Journal of Pediatric Endocrinology and Metabolism [Internet]. 2016;29:389-390. Website
Pafilis P, Lymberakis P, Sagonas K, Valakos E. The particularities of a remote islet shape the thermoregulatory profile of an endemic Mediterranean lizard. Journal of Thermal Biology. 2016;61:55-60.
Vassilakopoulos TP, Pangalis GA, Chatziioannou S, Papageorgiou S, Angelopoulou MK, Galani Z, Kourti G, Prassopoulos V, Leonidopoulou T, Terpos E, et al. PET/CT in primary mediastinal large B-cell lymphoma responding to rituximab-CHOP: An analysis of 106 patients regarding prognostic significance and implications for subsequent radiotherapy. Leukemia [Internet]. 2016;30(1):238 - 242. Website
Gavriatopoulou M, Kastritis E, Kyrtsonis M-C, Vassilakopoulos TP, Roussou M, Fotiou D, Migkou M, Mpakiri M, Tasidou A, Terpos E, et al. Phase 2 study of ofatumumab, fludarabine and cyclophosphamide in relapsed/refractory Waldenström’s macroglobulinemia. Leukemia and Lymphoma [Internet]. 2016:1 - 3. Website
Gavriatopoulou M, Kastritis E, Kyrtsonis M-C, Vassilakopoulos TP, Roussou M, Fotiou D, Migkou M, Mpakiri M, Tasidou A, Terpos E, et al. Phase 2 study of ofatumumab, fludarabine and cyclophosphamide in relapsed/refractory Waldenström’s macroglobulinemia. Leukemia and Lymphoma [Internet]. 2016:1 - 3. Website
Zhao J, Sakellariou G, Green PF. Phase behavior of diblock copolymer/star-shaped polymer thin film mixtures. Soft Matter [Internet]. 2016;12:3849-3853. Publisher's VersionAbstract
We investigated the phase behavior of thin film, thickness h  100 nm, mixtures of a polystyrene-b-poly(2-vinylpyridine) (PS-b-P2VP) diblock copolymer with star-shaped polystyrene (SPS) molecules of varying functionalities f, where 4 < f < 64, and molecular weights per arm Marm. The miscibility of the system and the surface composition varied appreciably with Marm and f. For large values of Marm, regardless of f, the miscibility of the system was qualitatively similar to that of linear chain PS/PS-b-P2VP mixtures – the copolymer chains aggregate to form micelles, each composed of an inner P2VP core and PS corona, which preferentially segregate to the free surface. On the other hand, for large f and small Marm, SPS molecules preferentially resided at the free surface. Moreover, blends containing SPS molecules with the highest values of f and lowest values of Marm were phase separated. These observations are rationalized in terms of competing entropic interactions and the dependence of the surface tension of the star shaped molecules on Marm and f.
Protogerou AD, Aissopou EK, Argyris A, Nasothimiou EG, Konstantonis GD, Karamanou M, Papaioannou TG, Blacher J, Safar ME, Sfikakis PP. Phenotypes of office systolic blood pressure according to both brachial and aortic measurements: Frequencies and associations with carotid hypertrophy in 1861 adults. Journal of Hypertension [Internet]. 2016;34(7):1325 - 1330. Website
Alevizaki A, Sainidou R, Rembert P, Morvan B, Stefanou N. Phononic crystals of poroelastic spheres. Physical Review B. 2016;94(17):174306 (9 pages).Abstract
An extension of the layer-multiple-scattering method to phononic crystals of poroelastic spheres immersed in a fluid medium is developed. The applicability of the method is demonstrated on specific examples of close-packed fcc crystals of submerged water-saturated meso- and macroporous silica microspheres. It is shown that, by varying the pore size and/or the porosity, the transmission, reflection, and absorption spectra of finite slabs of these crystals are significantly altered. Strong absorption, driven by the slow waves in the poroelastic material and enhanced by multiple scattering, leads to negligible transmittance over an extended frequency range, which might be useful for practical applications in broadband acoustic shielding. The results are analyzed by reference to relevant phononic dispersion diagrams in the viscous and inertial coupling limits, and a consistent interpretation of the underlying physics is provided.
Chavrier D, Hovden J, Cazzoli S, Kamberidou I, Chroni S. Pioneers and outstanding women in national and international sports leadership. 2016. in_inspiratoinal_women_in_sport_book_cover.jpg inspirational_women_in_europe_making_a_difference_in_phys.ed_.sport_and_dance.pdf
Varytis P, Stefanou N. Plasmon-driven large Hall photon currents in light scattering by a core-shell magnetoplasmonic nanosphere. Journal of the Optical Society of America B. 2016;33(6):1286-1290.Abstract
The conditions for the occurrence of strong magnetotransverse anisotropy in light scattering by a single gyrotropic sphere are investigated by means of rigorous full electrodynamic multipole calculations. It is shown that composite magnetoplasmonic spherical scatterers with a core–shell morphology can induce large and tunable plasmon-driven Hall photon currents, which appear even in the case of subwavelength particles. Explicit results for silver-coated bismuth-substituted yttrium iron garnet nanospheres are presented and analyzed.
Sadori L, Koutsodendris A, Masi A, Bertini A, Combourieu-Nebout N, Franke A, Kouli K, Joannin S, Mercuri AM, Panagiotopoulos K, et al. Pollen-based paleoenvironmental and paleoclimatic changes at Lake Ohrid (SE Europe) during the past 500 ka. Biogeosciences [Internet]. 2016;13:1423-1437. Publisher's VersionAbstract
Lake Ohrid is located at the border between FYROM (Former Yugoslavian Republic of Macedonia) and Albania and formed during the latest phases of Alpine orogenesis. It is the deepest, the largest and the oldest tectonic lake in Europe. To better understand the paleoclimatic and paleoenvironmental evolution of Lake Ohrid, deep drilling was carried out in 2013 within the framework of the Scientific Collaboration on Past Speciation Conditions (SCOPSCO) project that was funded by the International Continental Scientific Drilling Program (ICDP). Preliminary results indicate that lacustrine sedimentation of Lake Ohrid started between 1.2 and 1.9 Ma ago. Here we present new pollen data (selected percentage and concentration taxa/groups) of the uppermost  ∼  200 m of the 569 m long DEEP core drilled in the depocentre of Lake Ohrid. The study is the fruit of a cooperative work carried out in several European palynological laboratories. The age model of this part of the core is based on 10 tephra layers and on tuning of biogeochemical proxy data to orbital parameters. According to the age model, the studied sequence covers the last  ∼  500 000 years at a millennial-scale resolution ( ∼  1.6 ka) and records the major vegetation and climate changes that occurred during the last 12 (13 only pro parte) marine isotope stages (MIS). Our results indicate that there is a general good correspondence between forested/non-forested periods and glacial–interglacial cycles of the marine isotope stratigraphy. The record shows a progressive change from cooler and wetter to warmer and drier interglacial conditions. This shift in temperature and moisture availability is visible also in vegetation during glacial periods. The period corresponding to MIS11 (pollen assemblage zone OD-10, 428–368 ka BP) is dominated by montane trees such as conifers. Mesophilous elements such as deciduous and semi-deciduous oaks dominate forest periods of MIS5 (PASZ OD-3, 129–70 ka BP) and MIS1 (PASZ OD-1, 14 ka BP to present). Moreover, MIS7 (PASZ OD-6, 245–190 ka) shows a very high interglacial variability, with alternating expansions of montane and mesophilous arboreal taxa. Grasslands (open vegetation formations requiring relatively humid conditions) characterize the earlier glacial phases of MIS12 (PASZ OD-12, 488–459 ka), MIS10 (corresponding to the central part of PASZ OD-10, 428–366 ka) and MIS8 (PASZ OD-7, 288–245 ka). Steppes (open vegetation formations typical of dry environments) prevail during MIS6 (OD-5 and OD-4, 190–129 ka) and during MIS4-2 (PASZ OD-2, 70–14 ka). Our palynological results support the notion that Lake Ohrid has been a refugium area for both temperate and montane trees during glacials. Closer comparisons with other long southern European and Near Eastern pollen records will be achieved through ongoing high-resolution studies.
Matekovits A, Dalamaga M, Stratigos A, Katsambas A, Antoniou C. Polymorphous light eruption under the Mediterranean sun: a clinico-epidemiological and photobiological study. Eur J Dermatol. 2016;26(3):304-6.
Siegel DS, Weisel KC, Dimopoulos MA, Baz R, Richardson P, Delforge M, Song KW, San Miguel JF, Moreau P, Goldschmidt H, et al. Pomalidomide plus low-dose dexamethasone in patients with relapsed/refractory multiple myeloma and moderate renal impairment: a pooled analysis of three clinical trials. Leukemia and Lymphoma [Internet]. 2016;57(12):2833 - 2838. WebsiteAbstract
Renal impairment (RI) is a major comorbidity in patients with multiple myeloma (MM). Here we present the pooled safety and efficacy analysis of three clinical trials (MM-002, MM-003, and MM-010) of pomalidomide + low-dose dexamethasone (POM + LoDEX) in patients with moderate RI (creatinine clearance [CrCl] ≥ 30 to <60 mL/min) and without RI (≥ 60 mL/min). Trial protocols were approved by the institutional review board of each site involved. Patients with RI were older than patients without RI, although other baseline characteristics were similar. The dosing and safety profile of POM + LoDEX was similar across RI subgroups. Median overall response rate, progression-free survival, time to progression, and duration of response were not significantly different between RI subgroups. However, patients with vs. without RI had significantly shorter median overall survival (10.5 vs. 14.0 months, respectively; p =.004). This analysis demonstrates that POM + LoDEX is a safe and effective treatment for patients with moderate RI. The trials were registered at ClinicalTrials.gov as NCT00833833 (MM-002), NCT01311687 (MM-003), and NCT01712789 (MM-010) and at EudraCT as 2010-019820-30 (MM-003) and 2012-001888-78 (MM-010). © 2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
Siegel DS, Weisel KC, Dimopoulos MA, Baz R, Richardson P, Delforge M, Song KW, San Miguel JF, Moreau P, Goldschmidt H, et al. Pomalidomide plus low-dose dexamethasone in patients with relapsed/refractory multiple myeloma and moderate renal impairment: a pooled analysis of three clinical trials. Leukemia and Lymphoma [Internet]. 2016;57(12):2833 - 2838. WebsiteAbstract
Renal impairment (RI) is a major comorbidity in patients with multiple myeloma (MM). Here we present the pooled safety and efficacy analysis of three clinical trials (MM-002, MM-003, and MM-010) of pomalidomide + low-dose dexamethasone (POM + LoDEX) in patients with moderate RI (creatinine clearance [CrCl] ≥ 30 to <60 mL/min) and without RI (≥ 60 mL/min). Trial protocols were approved by the institutional review board of each site involved. Patients with RI were older than patients without RI, although other baseline characteristics were similar. The dosing and safety profile of POM + LoDEX was similar across RI subgroups. Median overall response rate, progression-free survival, time to progression, and duration of response were not significantly different between RI subgroups. However, patients with vs. without RI had significantly shorter median overall survival (10.5 vs. 14.0 months, respectively; p =.004). This analysis demonstrates that POM + LoDEX is a safe and effective treatment for patients with moderate RI. The trials were registered at ClinicalTrials.gov as NCT00833833 (MM-002), NCT01311687 (MM-003), and NCT01712789 (MM-010) and at EudraCT as 2010-019820-30 (MM-003) and 2012-001888-78 (MM-010). © 2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
Ou Y, Doshi S, Nguyen A, Jonsson F, Aggarwal S, Rajangam K, Dimopoulos MA, Stewart AK, Badros A, Papadopoulos KP, et al. Population Pharmacokinetics and Exposure-Response Relationship of Carfilzomib in Patients With Multiple Myeloma. Journal of Clinical Pharmacology [Internet]. 2016. WebsiteAbstract
A population pharmacokinetic (PK) model and exposure-response (E-R) analysis was developed using data collected from 5 phase 1b/2 and 2 phase 3 studies in subjects with multiple myeloma. Subjects receiving intravenous infusion on 2 consecutive days each week for 3 weeks (days 1, 2, 8, 9, 15, and 16) in each cycle at doses ranging from 15 to 20/56 mg/m2 (20 mg/m2 in cycle 1 and, if tolerated, escalated to 56 mg/m2 on day 8 of cycle 1). The population PK analysis indicated that among all the covariates tested, the only statistically significant covariate was body surface area on carfilzomib clearance; however, this covariate was unlikely to be clinically significant. Despite inclusion of different populations (relapsed or relapsed/refractory), treatments (carfilzomib monotherapy or combination therapy), infusion lengths (2 to 10 minutes or 30 minutes), and different doses, the E-R analysis of efficacy showed that after adjusting for baseline characteristics, higher area under the concentration-time curve was associated with improved overall response rate (ORR), from 15 to 20/56 mg/m2. No positive relationships between maximum concentration and ORR were identified, indicating that ORR would not be expected to be impacted by infusion length. For safety end points, no statistically significant relationship between exposure and increasing risk of adverse events was identified. The results of an E-R analysis provided strong support for a carfilzomib dose at 20/56 mg/m2 as a 30-minute infusion for monotherapy and combination therapy. This article illustrates an example of application of E-R analysis to support labeling dose recommendation in the absence of extensive clinical data. © 2016, The American College of Clinical Pharmacology.
Lekkas E, Filis C, Andreadakis E, Skourtsos E, Diakakis M, Mavroulis S, Papaspyropoulos K, Alexoudi V, Kommatas M, Karalemas N, et al. Post-Fire Hazard and Risk Assessment in Fire-Affected Areas with GIS and Satellite Imagery: The Case of 2015 Laconia Forest Fire (Southeastern Peloponnese, Greece). In: Safe Greece - Safe Evros 2016. Alexandroupoli; 2016. pdfAbstract
On July 17, 2015 a forest fire that broke out in the southern part of Epidavros Limira peninsula (Laconia, southeastern Peloponnese), expanded rapidly due to strong winds blowing in the area and raged out of control for two days, inducing substantial damage to agriculture, livestock farming, buildings and infrastructure and causing one fatality. Innovative GIS-based methods were developed and implemented for the first time in a fire-affected area in Greece for mapping the post-fire erosion, flood and landslide hazards and risks. Geomorphological, geological, tectonic, hydrological, meteorological and land-use data along with a WorldView-2 satellite image and post-fire field observations were evaluated and used. A newly developed method was applied for assessing the erosion hazard. Analytic Hierarchy Process and Weighted Linear Combination methods were used for assessing the post-fire landslide susceptibility. The HEC-RAS model was used for hydraulic simulation and assessment of flood risk under post-fire conditions. Post-fire erosion, flood and landslide hazard and risk maps were constructed for the affected area delineating locations with very low, low, moderate, high or very high hazard and risk of erosion, flood and landslide respectively. The developed methodology is a useful post-fire hazard and risk assessment tool and can be applied by state authorities to assess the geo-environmental impact of fire disasters in areas with similar environmental conditions.
Vavouranakis G. A post-humanist approach to funerary ritual and its socio-historical significance: the Early and Middle Bronze tools tombs at Apesokari, Crete. In: Dakouri-Hild A, Boyd M Staging Death: Funerary Performance, Architecture and Landscape in the Aegean. Berlin: De Gruyter; 2016. pp. 253-273.
Moreau P, Van De Donk NWCJ, Miguel JS, Lokhorst H, Nahi H, Ben-Yehuda D, Cavo M, Cook G, Delforge M, Einsele H, et al. Practical Considerations for the Use of Daratumumab, a Novel CD38 Monoclonal Antibody, in Myeloma. Drugs [Internet]. 2016;76(8):853 - 867. WebsiteAbstract
Monoclonal antibodies (mAbs) are a recent addition to multiple myeloma (MM) therapies and a number of mAbs directed at myeloma cell surface molecules are in development. Daratumumab is a CD38 mAb that has demonstrated substantial activity and good tolerability in four phase I, phase I/II and phase II studies as monotherapy, as well as in combination with current standard treatments in MM. The positive results obtained in the relapsed/refractory setting in patients with advanced-stage disease and in a small number of patients with newly diagnosed disease provide the rationale for the investigation of the agent in a number of ongoing phase III trials. mAbs are generally better tolerated than conventional chemotherapy; however, their use requires other special considerations. Such factors include those common to all mAbs, namely infusion-related reactions, but also factors that are observed with mAbs used in myeloma, such as interference with response assessment, or factors that are related to CD38 mAbs such as daratumumab, for instance blood typing interference. Our review provides an overview of the results from the daratumumab clinical trials conducted to date, as well as practical management considerations for the use of daratumumab based on our experience with the agent. © 2016 Springer International Publishing Switzerland.
Moreau P, Van De Donk NWCJ, Miguel JS, Lokhorst H, Nahi H, Ben-Yehuda D, Cavo M, Cook G, Delforge M, Einsele H, et al. Practical Considerations for the Use of Daratumumab, a Novel CD38 Monoclonal Antibody, in Myeloma. Drugs [Internet]. 2016;76(8):853 - 867. WebsiteAbstract
Monoclonal antibodies (mAbs) are a recent addition to multiple myeloma (MM) therapies and a number of mAbs directed at myeloma cell surface molecules are in development. Daratumumab is a CD38 mAb that has demonstrated substantial activity and good tolerability in four phase I, phase I/II and phase II studies as monotherapy, as well as in combination with current standard treatments in MM. The positive results obtained in the relapsed/refractory setting in patients with advanced-stage disease and in a small number of patients with newly diagnosed disease provide the rationale for the investigation of the agent in a number of ongoing phase III trials. mAbs are generally better tolerated than conventional chemotherapy; however, their use requires other special considerations. Such factors include those common to all mAbs, namely infusion-related reactions, but also factors that are observed with mAbs used in myeloma, such as interference with response assessment, or factors that are related to CD38 mAbs such as daratumumab, for instance blood typing interference. Our review provides an overview of the results from the daratumumab clinical trials conducted to date, as well as practical management considerations for the use of daratumumab based on our experience with the agent. © 2016 Springer International Publishing Switzerland.
Mertzimekis TJ. Prediction and evaluation of magnetic moments in $T$=1/2, 3/2, and 5/2 mirror nuclei. Phys. Rev. C. 2016;94:064313.
Karampas GA, Eleftheriades MI, Panoulis KC, Rizou MD, Haliassos AD, Metallinou DK, Mastorakos GP, Rizos DA. Prediction of pre-eclampsia combining NGAL and other biochemical markers with Doppler in the first and/or second trimester of pregnancy. A pilot study. European Journal of Obstetrics Gynecology and Reproductive Biology [Internet]. 2016;205:153-157. Website
Nastos PT, Dalezios NR. Preface: Advances in meteorological hazards and extreme events. Natural Hazards and Earth System Sciences [Internet]. 2016;16(5):1259 - 1268. Website
Bizopoulos PA, Vavuranakis M, Papaioannou TG, Vrachatis DA, Sakellarios AI, Iliopoulou D, Tousoulis D, Koutsouris DD, Fotiadis DI. A preliminary study on In-Vivo 3-D imaging of Bioprosthetic Aortic Valve deformation. In: IFMBE Proceedings. Vol. 57. ; 2016. pp. 332 - 336. Website
Papadavid E, Katsimbri P, Kapniari I, Koumaki D, Karamparpa A, Dalamaga M, Tzannis K, Βoumpas D, Rigopoulos D. Prevalence of psoriatic arthritis and its correlates among patients with psoriasis in Greece: results from a large retrospective study. J Eur Acad Dermatol Venereol. 2016;30(10):1749-1752.Abstract
OBJECTIVES: To evaluate the prevalence and its clinical characteristics of psoriatic arthritis (PsA) in a specialized psoriasis clinic of a University Hospital. METHODS: In this retrospective study, 278 patients with psoriasis were evaluated between 2011 and 2013. RESULTS: The study included 278 patients with psoriasis: 144 (52%) were male and 134 (48%) female. Their median age was 51.41 with median psoriasis presenting age of 34.52 years. Referring to the type of psoriasis, 86% presented with plaque psoriasis, 5% guttate, 2% palms and soles, 2% inverse, 1% pustular and 4% with psoriasis of more than one type. Nail disease appeared in 121 patients (43.5%) and scalp disease in 175 (63%). Of these patients, 85 (30%) had PsA, whereas 51% of patients with PsA had psoriatic nail disease. With reference to the PsA type, 43 (51%) patients presented with polyarthritis, 10 (12%) with oligoarthritis, 7 (8%) with axial arthritis, whereas the rest 25 of them (31%) had PsA of more than one type. The subgroup of patients with PsA had significantly higher rates of comorbidities including arterial hypertension, diabetes and hypercholesterolaemia compared to non-PsA patients with 41% vs. 17% (P = 0.001), 20% vs. 8% (P = 0.021) and 41% vs. 19% (P = 0.004), respectively. CONCLUSION: The prevalence of PsA among patients with psoriasis was relatively higher in Greece compared to other ethnic-based studies. Comorbidities related to life expectancy were more frequent. As there is a high percentage of undiagnosed cases with active arthritis among patients with psoriasis, dermatologists should be aware of PsA clinical signs in order to recognize it earlier and provide successful treatment.
Cohen YC, Joffe E, Benyamini N, Dimopoulos MA, Terpos E, Trestman S, Held-Kuznetsov V, Avivi I, Kastritis E. Primary failure of bortezomib in newly diagnosed multiple myeloma-understanding the magnitude, predictors, and significance. Leukemia and Lymphoma [Internet]. 2016;57(6):1382 - 1388. WebsiteAbstract
Botezomib-based induction is highly effective for the treatment of newly diagnosed multiple myeloma (NDMM). We investigated the outcomes of NDMM patients who failed to respond to bortezomib-based induction in a real-life clinical setting. In a cohort of 295 consecutive NDMM patients in 3 medical centers, 74 (25%) failed to achieve at least partial response after 4 induction cycles, and were classified as non-responsive. Compared to induction responders, they were older, more frequently anemic, had a higher incidence of del17p and ISS-3, and a worse performance status. In multivariable analysis, bortezomib-based induction failure occurred in 25% of patients and was the strongest independent factor predicting mortality with a 5-fold hazard ratio (95% CI 1.44-8.68). Three-year overall survival in responsive vs. non-responsive patients were 76% vs. 53%, respectively (p < 0.0001). Survival from time of salvage second-line treatment was significantly shorter among induction non-responders vs. responders (25 months vs. not-reached, p = 0.024). © 2015 Taylor & Francis.
Cohen YC, Joffe E, Benyamini N, Dimopoulos MA, Terpos E, Trestman S, Held-Kuznetsov V, Avivi I, Kastritis E. Primary failure of bortezomib in newly diagnosed multiple myeloma-understanding the magnitude, predictors, and significance. Leukemia and Lymphoma [Internet]. 2016;57(6):1382 - 1388. WebsiteAbstract
Botezomib-based induction is highly effective for the treatment of newly diagnosed multiple myeloma (NDMM). We investigated the outcomes of NDMM patients who failed to respond to bortezomib-based induction in a real-life clinical setting. In a cohort of 295 consecutive NDMM patients in 3 medical centers, 74 (25%) failed to achieve at least partial response after 4 induction cycles, and were classified as non-responsive. Compared to induction responders, they were older, more frequently anemic, had a higher incidence of del17p and ISS-3, and a worse performance status. In multivariable analysis, bortezomib-based induction failure occurred in 25% of patients and was the strongest independent factor predicting mortality with a 5-fold hazard ratio (95% CI 1.44-8.68). Three-year overall survival in responsive vs. non-responsive patients were 76% vs. 53%, respectively (p < 0.0001). Survival from time of salvage second-line treatment was significantly shorter among induction non-responders vs. responders (25 months vs. not-reached, p = 0.024). © 2015 Taylor & Francis.
Yui JC, Van Keer J, Weiss BM, Waxman AJ, Palmer MB, D'Agati VD, Kastritis E, Dimopoulos MA, Vij R, Bansal D, et al. Proteasome inhibitor associated thrombotic microangiopathy. American Journal of Hematology [Internet]. 2016;91(9):E348 - E352. WebsiteAbstract
A variety of medications have been implicated in the causation of thrombotic microangiopathy (TMA). Recently, a few case reports have emerged of TMA attributed to the proteasome inhibitors (PI) bortezomib and carfilzomib in patients with multiple myeloma. The aim of this case series was to better characterize the role of PI in the etiology of drug-induced TMA. We describe eleven patients from six medical centers from around the world who developed TMA while being treated with PI. The median time between medication initiation and diagnosis of TMA was 21 days (range 5 days to 17 months). Median laboratory values at diagnosis included hemoglobin—7.5 g dL−1, platelet count—20 × 109/L, LDH—698 U L−1, creatinine—3.12 mg dL−1. No patient had any other cause of TMA, including ADAMTS13 inhibition, other malignancy or use of any other medication previously associated with TMA. Nine patients had resolution of TMA without evidence of hemolysis after withdrawal of PI. Two patients had stabilization of laboratory values but persistent evidence of hemolysis despite medication withdrawal. One patient had recurrence of TMA with rechallenge of PI. There is a strong level of evidence that PI can cause DITMA. In evaluating patients with suspected TMA, PI use should be recognized as a potential etiology, and these medications should be discontinued promptly if thought to be the cause of TMA. Am. J. Hematol. 91:E348–E352, 2016. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.
Yui JC, Van Keer J, Weiss BM, Waxman AJ, Palmer MB, D'Agati VD, Kastritis E, Dimopoulos MA, Vij R, Bansal D, et al. Proteasome inhibitor associated thrombotic microangiopathy. American Journal of Hematology [Internet]. 2016;91(9):E348 - E352. WebsiteAbstract
A variety of medications have been implicated in the causation of thrombotic microangiopathy (TMA). Recently, a few case reports have emerged of TMA attributed to the proteasome inhibitors (PI) bortezomib and carfilzomib in patients with multiple myeloma. The aim of this case series was to better characterize the role of PI in the etiology of drug-induced TMA. We describe eleven patients from six medical centers from around the world who developed TMA while being treated with PI. The median time between medication initiation and diagnosis of TMA was 21 days (range 5 days to 17 months). Median laboratory values at diagnosis included hemoglobin—7.5 g dL−1, platelet count—20 × 109/L, LDH—698 U L−1, creatinine—3.12 mg dL−1. No patient had any other cause of TMA, including ADAMTS13 inhibition, other malignancy or use of any other medication previously associated with TMA. Nine patients had resolution of TMA without evidence of hemolysis after withdrawal of PI. Two patients had stabilization of laboratory values but persistent evidence of hemolysis despite medication withdrawal. One patient had recurrence of TMA with rechallenge of PI. There is a strong level of evidence that PI can cause DITMA. In evaluating patients with suspected TMA, PI use should be recognized as a potential etiology, and these medications should be discontinued promptly if thought to be the cause of TMA. Am. J. Hematol. 91:E348–E352, 2016. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.
Foivas A, Malenović A, Kostić N, Božić M, Knežević M, Loukas YL, Dotsikas Y. Quantitation of brinzolamide in dried blood spots by a novel LC-QTOF-MS/MS method. Journal of Pharmaceutical and Biomedical Analysis [Internet]. 2016;119:84-90. Website
Vrontaki E, Mavromoustakos T, Melagraki G, Afantitis A. Quantitative nanostructure-activity relationship models for the risk assessment of nanomaterials. In: Pharmaceutical Sciences: Breakthroughs in Research and Practice. Vol. 2. ; 2016. pp. 1314 - 1338. Website
Vrontaki E, Mavromoustakos T, Melagraki G, Afantitis A. Quantitative nanostructure-activity relationship models for the risk assessment of nanomaterials. In: Pharmaceutical Sciences: Breakthroughs in Research and Practice. Vol. 2. ; 2016. pp. 1314 - 1338. Website
Karamanou M, Tekiner H, Papaioannou TG, Konstantopoulos K, Androutsos G. Racial variation and cancer: A historical approach. Journal of B.U.ON. [Internet]. 2016;21(6):1568 - 1570. Website
Kastritis E, Dimopoulos MA. Recent advances in the management of AL Amyloidosis. British Journal of Haematology [Internet]. 2016;172(2):170 - 186. WebsiteAbstract
Immunoglobulin light chain (AL) amyloidosis, the most common of the systemic amyloidosis, is characterized by the deposition of amyloid fibrils that derive from the aggregation of misfolded monoclonal immunoglobulin light chains. Amyloid fibrils disrupt tissue architecture and the pre-fibril oligomers are directly toxic to myocardiac cells, causing cardiac dysfunction. The lethal consequences of AL amyloidosis are due to the toxic product and not due to the malignant behaviour of the plasma cell clone however, the characteristics of this clone are associated with long-term prognosis. Early and accurate diagnosis is the key to effective management, but is challenging. Modern chemotherapy options (including autologous transplantation, bortezomib, lenalidomide) have improved the outcomes of patients at low or intermediate risk, but the prognosis of patients with severe cardiac dysfunction is still poor. Therapies targeting amyloid deposits and the amyloidogenic process are under investigation and offer promise for better future treatments. © 2016 John Wiley & Sons Ltd.
Castillo JJ, Garcia-Sanz R, Hatjiharissi E, Kyle RA, Leleu X, McMaster M, Merlini G, Minnema MC, Morra E, Owen RG, et al. Recommendations for the diagnosis and initial evaluation of patients with Waldenström Macroglobulinaemia: A Task Force from the 8th International Workshop on Waldenström Macroglobulinaemia. British Journal of Haematology [Internet]. 2016;175(1):77 - 86. WebsiteAbstract
The diagnosis of Waldenström macroglobulinaemia (WM) can be challenging given the variety of signs and symptoms patients can present. Furthermore, once the diagnosis of WM is established, the initial evaluation should be thorough as well as appropriately directed. During the 8th International Workshop for WM in London, United Kingdom, a multi-institutional task force was formed to develop consensus recommendations for the diagnosis and initial evaluation of patients with WM. In this document, we present the results of the deliberations that took place to address these issues. We provide recommendations for history-taking and physical examination, laboratory studies, bone marrow aspiration and biopsy analysis and imaging studies. We also provide guidance on the initial evaluation of special situations, such as anaemia, hyperviscosity, neuropathy, Bing-Neel syndrome and amyloidosis. We hope these recommendations serve as a practical guidance to clinicians taking care of patients with a suspected or an established diagnosis of WM. © 2016 John Wiley & Sons Ltd
Castillo JJ, Garcia-Sanz R, Hatjiharissi E, Kyle RA, Leleu X, McMaster M, Merlini G, Minnema MC, Morra E, Owen RG, et al. Recommendations for the diagnosis and initial evaluation of patients with Waldenström Macroglobulinaemia: A Task Force from the 8th International Workshop on Waldenström Macroglobulinaemia. British Journal of Haematology [Internet]. 2016;175(1):77 - 86. WebsiteAbstract
The diagnosis of Waldenström macroglobulinaemia (WM) can be challenging given the variety of signs and symptoms patients can present. Furthermore, once the diagnosis of WM is established, the initial evaluation should be thorough as well as appropriately directed. During the 8th International Workshop for WM in London, United Kingdom, a multi-institutional task force was formed to develop consensus recommendations for the diagnosis and initial evaluation of patients with WM. In this document, we present the results of the deliberations that took place to address these issues. We provide recommendations for history-taking and physical examination, laboratory studies, bone marrow aspiration and biopsy analysis and imaging studies. We also provide guidance on the initial evaluation of special situations, such as anaemia, hyperviscosity, neuropathy, Bing-Neel syndrome and amyloidosis. We hope these recommendations serve as a practical guidance to clinicians taking care of patients with a suspected or an established diagnosis of WM. © 2016 John Wiley & Sons Ltd
Moreau P, Weisel KC, Song KW, Gibson CJ, Saunders O, Sternas LA, Hong K, Zaki MH, Dimopoulos MA. Relationship of response and survival in patients with relapsed and refractory multiple myeloma treated with pomalidomide plus low-dose dexamethasone in the MM-003 trial randomized phase III trial (NIMBUS). Leukemia and Lymphoma [Internet]. 2016;57(12):2839 - 2847. WebsiteAbstract
Relapsed/refractory multiple myeloma (RRMM) patients have poor overall survival (OS). Pomalidomide plus low-dose dexamethasone (POM + LoDEX) significantly extends OS in RRMM vs. high-dose dexamethasone. Survival of patients with stable disease (SD) was compared to patients with progressive disease (PD) or ≥ partial response (≥PR) at cycles (C) 3, 5, and 7. Among 302 patients randomized to POM + LoDEX, at C3 19.2% achieved ≥ PR, 38.4% SD, and 14.6% PD. Patients with SD at C3 (17.4%) and C5 (13.6%) showed improved responses at C7. Median OS from randomization by response at C3 was 22.4 months for ≥ PR (n = 58, HR 0.66; 95% CI 0.40–1.08, p = 0.0976 vs. SD), 16.2 months for SD (n = 116), and 6.3 months for PD (n = 44, HR 3.43; 95% CI 2.23–5.27, p < 0.0001 vs. SD). Similar patterns were observed for C5 and C7. Results show that POM + LoDEX should be a standard treatment after lenalidomide and bortezomib, including in SD patients. © 2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
Moreau P, Weisel KC, Song KW, Gibson CJ, Saunders O, Sternas LA, Hong K, Zaki MH, Dimopoulos MA. Relationship of response and survival in patients with relapsed and refractory multiple myeloma treated with pomalidomide plus low-dose dexamethasone in the MM-003 trial randomized phase III trial (NIMBUS). Leukemia and Lymphoma [Internet]. 2016;57(12):2839 - 2847. WebsiteAbstract
Relapsed/refractory multiple myeloma (RRMM) patients have poor overall survival (OS). Pomalidomide plus low-dose dexamethasone (POM + LoDEX) significantly extends OS in RRMM vs. high-dose dexamethasone. Survival of patients with stable disease (SD) was compared to patients with progressive disease (PD) or ≥ partial response (≥PR) at cycles (C) 3, 5, and 7. Among 302 patients randomized to POM + LoDEX, at C3 19.2% achieved ≥ PR, 38.4% SD, and 14.6% PD. Patients with SD at C3 (17.4%) and C5 (13.6%) showed improved responses at C7. Median OS from randomization by response at C3 was 22.4 months for ≥ PR (n = 58, HR 0.66; 95% CI 0.40–1.08, p = 0.0976 vs. SD), 16.2 months for SD (n = 116), and 6.3 months for PD (n = 44, HR 3.43; 95% CI 2.23–5.27, p < 0.0001 vs. SD). Similar patterns were observed for C5 and C7. Results show that POM + LoDEX should be a standard treatment after lenalidomide and bortezomib, including in SD patients. © 2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
Papaioannou TG, Stamatelopoulos K, Tousoulis D. Repeatability of different segmental pulse wave velocity measurements. American Journal of Hypertension [Internet]. 2016;29(7):889. Website
Responding to thanks: divergence between native speakers and FL learners of Greek and the consequences for establishing rapport
Bella S. Responding to thanks: divergence between native speakers and FL learners of Greek and the consequences for establishing rapport. Glossologia [Internet]. 2016;24:61-73. Publisher's Version
Angelopoulou V, Kouvaris E, Lagaki V, Mertzimekis TJ, Papagiannis P. Resurrected from the dead: Full characterization of an old HPGe detector using γ-ray and CT tomographies coupled to standard calibration techniques and simulations. In: Hellenic Nuclear Physics Society; 2016.
Diémoz H, Eleftheratos K, Kazadzis S, Amiridis V, Zerefos CS. Retrieval of aerosol optical depth in the visible range with a Brewer spectrophotometer in Athens. Atmospheric Measurement Techniques [Internet]. 2016;9:1871-1888. Publisher's Version a29_amt_2016.pdf
Despotopoulou A. Review of Charlotte Mathieson, Mobility in the Victorian Novel: Placing the Nation. Journal of Transport History. 2016;37(2):272-274.
Despotopoulou A. Review of Martha Banta, Henry James: An "Alien's" History of America. Americana [Internet]. 2016;XII(2). Publisher's Version
Fotiou D, Gerotziafas G, Kastritis E, Dimopoulos MA, Terpos E. A review of the venous thrombotic issues associated with multiple myeloma. Expert Review of Hematology [Internet]. 2016;9(7):695 - 706. WebsiteAbstract
Introduction: Patients with multiple myeloma (MM) have an increased risk of venous thromboembolic (VTE) complications. The first reports of high VTE rates date back to 1999 but became more apparent with the introduction of novel agents in the treatment of MM and mostly with immunomodulatory drugs (IMiDs; thalidomide, lenalidomide and pomalidomide). Areas covered: Currently thromboprophylaxis is recommended for patients who receive IMiDs-based regimens and the type of thrombophrophylaxis is based on patient-, disease- and treatment-related risk factors. Making the distinction between the intrinsic risk of thrombosis in MM and the effect of therapy is crucial. The use of aspirin, low molecular weight heparins and warfarin are the recommended drugs but despite their appropriate use the rates of VTE are not completely eliminated. Expert commentary: Research into biomarkers of increased coagulability and their incorporation in risk assessment models could identify patients most likely to benefit from thromboprophylaxis but such models are not widely used in myeloma. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
Fotiou D, Gerotziafas G, Kastritis E, Dimopoulos MA, Terpos E. A review of the venous thrombotic issues associated with multiple myeloma. Expert Review of Hematology [Internet]. 2016;9(7):695 - 706. WebsiteAbstract
Introduction: Patients with multiple myeloma (MM) have an increased risk of venous thromboembolic (VTE) complications. The first reports of high VTE rates date back to 1999 but became more apparent with the introduction of novel agents in the treatment of MM and mostly with immunomodulatory drugs (IMiDs; thalidomide, lenalidomide and pomalidomide). Areas covered: Currently thromboprophylaxis is recommended for patients who receive IMiDs-based regimens and the type of thrombophrophylaxis is based on patient-, disease- and treatment-related risk factors. Making the distinction between the intrinsic risk of thrombosis in MM and the effect of therapy is crucial. The use of aspirin, low molecular weight heparins and warfarin are the recommended drugs but despite their appropriate use the rates of VTE are not completely eliminated. Expert commentary: Research into biomarkers of increased coagulability and their incorporation in risk assessment models could identify patients most likely to benefit from thromboprophylaxis but such models are not widely used in myeloma. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
Mazis I, Sotiropoulos I. The role of energy as a geopolitical factor for the consolidation of Greek-Israeli relations. Regional Science Inquiry. 2016;(Special Issue):27-44.Abstract
During the current historical coincidence, the geostrategic conjunction of Greece-Cyprus- Israel is a reality, in order for the three states to cope in the best possible manner with the contemporary and future challeng