Publications

2016
Theodosopoulos GV, Hurley CM, Mays JW, Sakellariou G, Baskaran D. Trifunctional organolithium initiator for living anionic polymerization in hydrocarbon solvents in the absence of polar additives. Polymer Chemistry [Internet]. 2016;7:4090-4099. Publisher's VersionAbstract
A novel hydrocarbon-soluble trifunctional organolithium initiator, with no polar-additive requirements, has been synthesized for use in anionic polymerization. The complete synthesis of the unsaturated tri-diphenylethylene compound, 4,4,4-(ethane-1,1,1-triyl)tris(((3-(1-phenylvinyl)benzyl)oxy)benzene) (I), is described and the efficiency of the new initiator is evaluated using 1H NMR and Nano-assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (NALDI-TOF MS). Activation of precursor I, was performed in situ using stoichiometric amounts of sec-BuLi in benzene. Three-arm polystyrene and polyisoprene stars with narrow molecular weight distributions were obtained in the case of relatively high total anion concentration, [sec-BuLi]0 > 3.8 × 10−3 mol L−1 (3 × [I]0). At low total anion concentrations, uncontrolled molecular weight and broad/bimodal distributions were obtained, plausibly attributed to the presence of partially solvated aggregation dynamics complicating the propagation. The ‘living’ nature of the polymerization was confirmed by the sequential polymerization of styrene, and isoprene. The viscometric branching factor g’ values of the final branched polymers were measured and compared to g’ values of three-arm stars reported in the literature.
Koutsoukos K, Tzannis K, Christodoulou C, Karavasilis V, Bakoyiannis C, Makatsoris T, Papandreou CN, Pectasides D, Dimopoulos MA, Bamias A. Two cycles of adjuvant carboplatin in stage I seminoma: 8-year experience by the Hellenic Cooperative Oncology Group (HECOG). World Journal of Urology [Internet]. 2016;34(6):853 - 857. WebsiteAbstract
Purpose: Following the establishment of adjuvant carboplatin in stage I testicular seminoma as a standard, we adopted this treatment for all stage I seminoma patients. We report our 8-year experience and compare these results with our previous adjuvant etoposide/cisplatin (EP) strategy. Patients and methods: Patients with stage I seminoma, treated with adjuvant carboplatin and with a minimum follow-up of 1 year, were included. Two cycles of carboplatin [area under the curve (AUC) 6] were administered. Results: A total of 138 patients with median age of 34 years, treated from September 2003 to December 2011, were selected. There were 5 relapses [5-year relapse-free rate (RFR) 96.8 % (95 % confidence interval 91.6–98.8)]: 3 relapses at retroperitoneal lymph nodes, 1 relapse at the adrenal gland, and 1 isolated brain metastasis. Four patients with relapse were cured with salvage chemotherapy. All patients with relapse had tumor diameter ≥4 cm and/or age ≤34 years. Patients with at least 1 of the above risk factors (n = 111) had a significantly higher relapse rate compared with a similar population (n = 64) treated with 2 cycles of adjuvant EP: 5-year RFR was 95 % (SE 2 %) versus 100 % (SE 0 %), (p = 0.067). Conclusions: Age and tumor diameter were associated with relapse in stage I seminoma treated with adjuvant carboplatin. Although adjuvant carboplatin in patients with age ≤34 and/or tumor diameter ≥4 cm is associated with higher relapse rates than EP, the prognosis of these patients is excellent, and therefore, the use of less toxic treatment is justified. © 2015, Springer-Verlag Berlin Heidelberg.
Koutsoukos K, Tzannis K, Christodoulou C, Karavasilis V, Bakoyiannis C, Makatsoris T, Papandreou CN, Pectasides D, Dimopoulos MA, Bamias A. Two cycles of adjuvant carboplatin in stage I seminoma: 8-year experience by the Hellenic Cooperative Oncology Group (HECOG). World Journal of Urology [Internet]. 2016;34(6):853 - 857. WebsiteAbstract
Purpose: Following the establishment of adjuvant carboplatin in stage I testicular seminoma as a standard, we adopted this treatment for all stage I seminoma patients. We report our 8-year experience and compare these results with our previous adjuvant etoposide/cisplatin (EP) strategy. Patients and methods: Patients with stage I seminoma, treated with adjuvant carboplatin and with a minimum follow-up of 1 year, were included. Two cycles of carboplatin [area under the curve (AUC) 6] were administered. Results: A total of 138 patients with median age of 34 years, treated from September 2003 to December 2011, were selected. There were 5 relapses [5-year relapse-free rate (RFR) 96.8 % (95 % confidence interval 91.6–98.8)]: 3 relapses at retroperitoneal lymph nodes, 1 relapse at the adrenal gland, and 1 isolated brain metastasis. Four patients with relapse were cured with salvage chemotherapy. All patients with relapse had tumor diameter ≥4 cm and/or age ≤34 years. Patients with at least 1 of the above risk factors (n = 111) had a significantly higher relapse rate compared with a similar population (n = 64) treated with 2 cycles of adjuvant EP: 5-year RFR was 95 % (SE 2 %) versus 100 % (SE 0 %), (p = 0.067). Conclusions: Age and tumor diameter were associated with relapse in stage I seminoma treated with adjuvant carboplatin. Although adjuvant carboplatin in patients with age ≤34 and/or tumor diameter ≥4 cm is associated with higher relapse rates than EP, the prognosis of these patients is excellent, and therefore, the use of less toxic treatment is justified. © 2015, Springer-Verlag Berlin Heidelberg.
Michopoulos S, Chouzouri VI, Manios ED, Grapsa E, Antoniou Z, Papadimitriou CA, Zakopoulos N, Dimopoulos A-M. Untreated newly diagnosed essential hypertension is associated with nonalcoholic fatty liver disease in a population of a hypertensive center. Clinical and Experimental Gastroenterology [Internet]. 2016;9:1 - 9. WebsiteAbstract
Purpose: Recent studies have demonstrated that hypertension (HTN) is associated with non- alcoholic fatty liver disease (NAFLD) in treated hypertensive patients. The aim of this study was to investigate the association between newly diagnosed essential HTN and NAFLD in untreated hypertensive patients. Patients and methods: A consecutive series of 240 subjects (143 hypertensives and 97 normotensives), aged 30-80 years, without diabetes mellitus were enrolled in the study. Subjects with 24-hour systolic blood pressure (SBP) values ≥130 mmHg and/or diastolic BP values ≥80 mmHg were defined as hypertensives. NAFLD was defined as the presence of liver hyperechogenicity on ultrasound. Results: Body mass index (P=0.002) and essential HTN (P=0.016) were independently associated with NAFLD in the multivariate logistic regression model. Furthermore, the multivariate analysis revealed that morning SBP (P=0.044) was independently associated with NAFLD. Conclusion: Untreated, newly diagnosed essential HTN is independently associated with NAFLD. Ambulatory BP monitoring could be used for the diagnosis of essential HTN in patients with NAFLD. © 2016 Michopoulos et al.
Hulin C, Belch A, Shustik C, Petrucci MT, Dührsen U, Lu J, Song K, Rodon P, Pégourié B, Garderet L, et al. Updated outcomes and impact of age with lenalidomide and low-dose dexamethasone or melphalan, prednisone, and thalidomide in the randomized, phase III FIRST trial. Journal of Clinical Oncology [Internet]. 2016;34(30):3609 - 3617. WebsiteAbstract
Purpose: This analysis of the FIRST trial in patients with newly diagnosed multiple myeloma (MM) ineligible for stem-cell transplantation examined updated outcomes and impact of patient age. Patients and Methods: Patients with untreated symptomatic MM were randomly assigned at a one-to-one-to-one ratio to lenalidomide plus low-dose dexamethasone until disease progression (Rd continuous), Rd for 72 weeks (18 cycles; Rd18), or melphalan, prednisone, and thalidomide (MPT; 72 weeks), stratified by age (≤ 75 v > 75 years), disease stage (International Staging System stage I/II v III), and country. The primary end point was progression-free survival. Rd continuous and MPT were primary comparators. Results: Between August 21, 2008, and March 7, 2011, 1,623 patients were enrolled (Rd continuous, n = 535; Rd18, n = 541; MPT, n = 547), including 567 (35%) age older than 75 years. Higher rates of advanced-stage disease and renal impairment were observed in patients older than 75 versus 75 years of age or younger. Rd continuous reduced the risk of progression or death compared with MPT by 31% (hazard ratio [HR], 0.69; 95% CI, 0.59 to 0.80; P <.001) overall, 36% (HR, 0.64; 95% CI, 0.53 to 0.77; P <.001) in patients age 75 years or younger, and 20% (HR, 0.80; 95% CI, 0.62 to 1.03; P =.084) in those age older than 75 years. Median overall survival was longer with Rd continuous than with MPT, including a 14-month difference in patients age older than 75 years. Progression-free survival with Rd18 was similar to that with MPT, and overall survival with Rd18 was marginally inferior to that with Rd continuous. Rates of grade 3 to 4 treatment-emergent adverse events were similar for Rd continuous-treated patients age 75 years or older and those age older than 75 years; however, older patients had more frequent lenalidomide dose reductions. Conclusion: Results support Rd continuous treatment as a new standard of care for stem-cell transplantation-ineligible patients with newly diagnosed MM of all ages. © 2016 by American Society of Clinical Oncology.
Hulin C, Belch A, Shustik C, Petrucci MT, Dührsen U, Lu J, Song K, Rodon P, Pégourié B, Garderet L, et al. Updated outcomes and impact of age with lenalidomide and low-dose dexamethasone or melphalan, prednisone, and thalidomide in the randomized, phase III FIRST trial. Journal of Clinical Oncology [Internet]. 2016;34(30):3609 - 3617. WebsiteAbstract
Purpose: This analysis of the FIRST trial in patients with newly diagnosed multiple myeloma (MM) ineligible for stem-cell transplantation examined updated outcomes and impact of patient age. Patients and Methods: Patients with untreated symptomatic MM were randomly assigned at a one-to-one-to-one ratio to lenalidomide plus low-dose dexamethasone until disease progression (Rd continuous), Rd for 72 weeks (18 cycles; Rd18), or melphalan, prednisone, and thalidomide (MPT; 72 weeks), stratified by age (≤ 75 v > 75 years), disease stage (International Staging System stage I/II v III), and country. The primary end point was progression-free survival. Rd continuous and MPT were primary comparators. Results: Between August 21, 2008, and March 7, 2011, 1,623 patients were enrolled (Rd continuous, n = 535; Rd18, n = 541; MPT, n = 547), including 567 (35%) age older than 75 years. Higher rates of advanced-stage disease and renal impairment were observed in patients older than 75 versus 75 years of age or younger. Rd continuous reduced the risk of progression or death compared with MPT by 31% (hazard ratio [HR], 0.69; 95% CI, 0.59 to 0.80; P <.001) overall, 36% (HR, 0.64; 95% CI, 0.53 to 0.77; P <.001) in patients age 75 years or younger, and 20% (HR, 0.80; 95% CI, 0.62 to 1.03; P =.084) in those age older than 75 years. Median overall survival was longer with Rd continuous than with MPT, including a 14-month difference in patients age older than 75 years. Progression-free survival with Rd18 was similar to that with MPT, and overall survival with Rd18 was marginally inferior to that with Rd continuous. Rates of grade 3 to 4 treatment-emergent adverse events were similar for Rd continuous-treated patients age 75 years or older and those age older than 75 years; however, older patients had more frequent lenalidomide dose reductions. Conclusion: Results support Rd continuous treatment as a new standard of care for stem-cell transplantation-ineligible patients with newly diagnosed MM of all ages. © 2016 by American Society of Clinical Oncology.
Gierens K, Eleftheratos K. Upper tropospheric humidity changes under constant relative humidity. Atmospheric Chemistry and Physics [Internet]. 2016;16:4159-4169. Publisher's Version a28_acp_2016.pdf
Bamias A, Peroukidis S, Stamatopoulou S, Tzannis K, Koutsoukos K, Andreadis C, Bozionelou V, Pistalmatzian N, Papatsoris A, Stravodimos K, et al. Utilization of Systemic Chemotherapy in Advanced Urothelial Cancer: A Retrospective Collaborative Study by the Hellenic Genitourinary Cancer Group (HGUCG). Clinical Genitourinary Cancer [Internet]. 2016;14(2):e153 - e159. WebsiteAbstract
Background Advanced urothelial cancer (AUCa) is associated with poor long-term survival. Two major concerns are related to nonexposure to cisplatin-based chemotherapy and poor outcome after relapse. Our purpose was to record patterns of practice in AUCa in Greece, focusing on first-line treatment and management of relapsed disease. Methods Patients with AUCa treated from 2011 to 2013 were included in the analysis. Fitness for cisplatin was assessed by recently established criteria. Results Of 327 patients treated with first-line chemotherapy, 179 (55%) did not receive cisplatin. Criteria for unfitness for cisplatin were: Eastern Cooperative Oncology Group (ECOG) performance status (PS) ≥ 2, 21%; creatinine clearance ≤ 60 mL/min, 55%; hearing impairment, 8%; neuropathy, 1%; and cardiac failure, 5%. Forty-six patients (27%) did not fulfill any criterion for unfitness for cisplatin. The main reasons for these deviations were comorbidities (28%) and advanced age (32%). Seventy-four (68%) of 109 patients who experienced a relapse received second-line chemotherapy. The most frequent reason for not offering second-line chemotherapy was poor PS or limited life expectancy (66%). Conclusion In line with international data, approximately 50% of Greek patients with AUCa do not receive cisplatin-based chemotherapy, although 27% of them were suitable for such treatment. In addition, about one third of patients with relapse did not receive second-line chemotherapy because of poor PS or short life expectancy. Enforcing criteria for fitness for cisplatin and earlier diagnosis of relapse represent 2 targets for improvement in current treatment practice for AUCa. © 2016 Elsevier Inc.
Bamias A, Peroukidis S, Stamatopoulou S, Tzannis K, Koutsoukos K, Andreadis C, Bozionelou V, Pistalmatzian N, Papatsoris A, Stravodimos K, et al. Utilization of Systemic Chemotherapy in Advanced Urothelial Cancer: A Retrospective Collaborative Study by the Hellenic Genitourinary Cancer Group (HGUCG). Clinical Genitourinary Cancer [Internet]. 2016;14(2):e153 - e159. WebsiteAbstract
Background Advanced urothelial cancer (AUCa) is associated with poor long-term survival. Two major concerns are related to nonexposure to cisplatin-based chemotherapy and poor outcome after relapse. Our purpose was to record patterns of practice in AUCa in Greece, focusing on first-line treatment and management of relapsed disease. Methods Patients with AUCa treated from 2011 to 2013 were included in the analysis. Fitness for cisplatin was assessed by recently established criteria. Results Of 327 patients treated with first-line chemotherapy, 179 (55%) did not receive cisplatin. Criteria for unfitness for cisplatin were: Eastern Cooperative Oncology Group (ECOG) performance status (PS) ≥ 2, 21%; creatinine clearance ≤ 60 mL/min, 55%; hearing impairment, 8%; neuropathy, 1%; and cardiac failure, 5%. Forty-six patients (27%) did not fulfill any criterion for unfitness for cisplatin. The main reasons for these deviations were comorbidities (28%) and advanced age (32%). Seventy-four (68%) of 109 patients who experienced a relapse received second-line chemotherapy. The most frequent reason for not offering second-line chemotherapy was poor PS or limited life expectancy (66%). Conclusion In line with international data, approximately 50% of Greek patients with AUCa do not receive cisplatin-based chemotherapy, although 27% of them were suitable for such treatment. In addition, about one third of patients with relapse did not receive second-line chemotherapy because of poor PS or short life expectancy. Enforcing criteria for fitness for cisplatin and earlier diagnosis of relapse represent 2 targets for improvement in current treatment practice for AUCa. © 2016 Elsevier Inc.
Siegel DS, Dimopoulos M, Jagannath S, Goldschmidt H, Durrant S, Kaufman JL, Leleu X, Nagler A, Offner F, Graef T, et al. VANTAGE 095: An International, Multicenter, Open-Label Study of Vorinostat (MK-0683) in Combination with Bortezomib in Patients with Relapsed and Refractory Multiple Myeloma. Clinical Lymphoma, Myeloma and Leukemia [Internet]. 2016;16(6):329 - 334.e1. WebsiteAbstract
Background The present global, open-label, single-arm, multicenter, phase IIb study was designed to determine the efficacy and tolerability of oral vorinostat combined with standard doses of bortezomib in patients with multiple myeloma considered refractory to novel myeloma agents. Patients and Methods Eligible patients were age ≥ 18 years, had received ≥ 2 previous regimens, had disease refractory to ≥ 1 previous bortezomib-containing regimen, and had received ≥ 1 dose of an immunomodulatory drug (thalidomide or lenalidomide)-based regimen. The patients received 21-day cycles of bortezomib (1.3 mg/m2 intravenously on days 1, 4, 8, and 11) plus oral vorinostat (400 mg/d on days 1-14). Oral dexamethasone, 20 mg, on the day of and the day after each dose of bortezomib could be added for patients with progressive disease after 2 cycles or no change after 4 cycles. The primary endpoint was the objective response rate. Results The objective response rate was 11.3% (95% confidence interval, 6.6%-17.7%), and the median duration of response was 211 days (range, 64-550 days). The median overall survival duration was 11.2 months (95% confidence interval, 8.5-14.4 months), with a 2-year survival rate of 32%. The frequently reported adverse events were thrombocytopenia (69.7%), nausea (57.0%), diarrhea (53.5%), anemia (52.1%), and fatigue (48.6%); the overall safety profile was consistent with that of bortezomib and vorinostat. Conclusion The combination of vorinostat and bortezomib is active in patients with multiple myeloma refractory to novel treatment modalities and offers a new therapeutic option for this difficult-to-treat patient population (ClinicalTrials.gov identifier, NCT00773838). © 2016 Elsevier Inc.
Siegel DS, Dimopoulos M, Jagannath S, Goldschmidt H, Durrant S, Kaufman JL, Leleu X, Nagler A, Offner F, Graef T, et al. VANTAGE 095: An International, Multicenter, Open-Label Study of Vorinostat (MK-0683) in Combination with Bortezomib in Patients with Relapsed and Refractory Multiple Myeloma. Clinical Lymphoma, Myeloma and Leukemia [Internet]. 2016;16(6):329 - 334.e1. WebsiteAbstract
Background The present global, open-label, single-arm, multicenter, phase IIb study was designed to determine the efficacy and tolerability of oral vorinostat combined with standard doses of bortezomib in patients with multiple myeloma considered refractory to novel myeloma agents. Patients and Methods Eligible patients were age ≥ 18 years, had received ≥ 2 previous regimens, had disease refractory to ≥ 1 previous bortezomib-containing regimen, and had received ≥ 1 dose of an immunomodulatory drug (thalidomide or lenalidomide)-based regimen. The patients received 21-day cycles of bortezomib (1.3 mg/m2 intravenously on days 1, 4, 8, and 11) plus oral vorinostat (400 mg/d on days 1-14). Oral dexamethasone, 20 mg, on the day of and the day after each dose of bortezomib could be added for patients with progressive disease after 2 cycles or no change after 4 cycles. The primary endpoint was the objective response rate. Results The objective response rate was 11.3% (95% confidence interval, 6.6%-17.7%), and the median duration of response was 211 days (range, 64-550 days). The median overall survival duration was 11.2 months (95% confidence interval, 8.5-14.4 months), with a 2-year survival rate of 32%. The frequently reported adverse events were thrombocytopenia (69.7%), nausea (57.0%), diarrhea (53.5%), anemia (52.1%), and fatigue (48.6%); the overall safety profile was consistent with that of bortezomib and vorinostat. Conclusion The combination of vorinostat and bortezomib is active in patients with multiple myeloma refractory to novel treatment modalities and offers a new therapeutic option for this difficult-to-treat patient population (ClinicalTrials.gov identifier, NCT00773838). © 2016 Elsevier Inc.
Malandri C, Soukis K, Maffione M, Özkaptan M, Vassilakis E, Lozios S, van Hinsbergen D. Vertical axis rotations accommodated along the ‘Mid-Cycladic Lineament’ on Paros Island in the extensional heart of the Aegean orocline (Greece). Lithosphere [Internet]. 2016;L575.1(doi:10.1130). pdfAbstract
The Aegean-west Anatolian orocline formed due to mainly post-15 Ma opposite rotations of its western and eastern limbs, which contributed to the opening of the Aegean back-arc basin. Stretching lineations in exhumed metamorphic complexes in this back-arc basin mimic the regional vertical axis rotation patterns and suggests that the oppositely rotating domains are bounded by the ‘Mid-Cycladic Lineament’, the tectonic nature of which is enigmatic. Some authors have proposed this lineament to be extensional fault accommodating orogen-parallel extension, while others considered it a transform fault. The island of Paros hosts the only exposure of the Mid-Cycladic Lineament: the northwest of the island contains E-trending and the southeast contains N trending stretching lineations. Here, we show new paleomagnetic results from isotropic, ~16 Ma granitoids that intruded both domains. These demonstrate that the trend difference resulted from post-16 Ma ~90° clockwise and 10° counterclockwise rotation of the northwest and southeast blocks, respectively. We show that a greenschist facies, semi-ductile to brittle, low-angle, southeast dipping normal fault zone, here identified as the Elitas Shear Zone that we interpret as the Mid-Cycladic Lineament accommodates this rotation difference on Paros. We conclude a two-stage exhumation history for Paros that is consistent with regional Aegean reconstructions. Between ~23 and 16 Ma, the metamorphic rocks of Paros exhumed from amphibolite-facies to greenschist facies conditions along a top-to-the-north detachment. The Elitas shear zone then started to exhume the northwestern clockwise rotating domain from below the southeastern, counterclockwise rotating domain since 16 Ma. We demonstrate at the only location at which a structure coinciding with Mid-Cycladic Lineament is exposed, it is extensional in nature, consistent with geometrical predictions that Aegean oroclinal bending must have been accommodated by combined orogen-normal and orogen-parallel extension.
Dimopoulos MA, Kastritis E, Ghobrial IM. Waldenström's macroglobulinemia: A clinical perspective in the era of novel therapeutics. Annals of Oncology [Internet]. 2016;27(2):233 - 240. WebsiteAbstract
Waldenström's macroglobulinemia (WM) is a rare, low-grade malignancy with no established standard of care. Rituximab regimens are most commonly used, supported by their efficacy in hematologic malignancies, including WM. A growing number of investigational regimens for WM have been evaluated in phase II clinical trials, including single-agent and combination strategies that include newer-generation monoclonal antibodies (ofatumumab and alemtuzumab), proteasome inhibitors (bortezomib and carfilzomib), immunomodulatory agents (thalidomide and lenalidomide), phosphoinositide 3-kinase/protein kinase B (Akt)/mammalian target of rapamycin pathway inhibitors (everolimus and perifosene), a Bruton's tyrosine kinase inhibitor (ibrutinib), and a histone deacetylase inhibitor (panobinostat). Other novel agents are in early-stage development for WM. International treatment guidelines for WM suggest suitable regimens in the newly diagnosed and relapsed/refractory settings, in accordance with patient age, disease presentation, and efficacy and safety profiles of particular drugs. These factors must be considered when choosing appropriate therapy for individual patients with WM, to maximize response and prolong survival, while minimizing the risk of adverse events. This review article provides a clinical perspective of the modern management of patients with WM, in the context of available trial data for novel regimens and recently updated treatment guidelines. © The Author 2015.
Dimopoulos MA, Kastritis E, Ghobrial IM. Waldenström's macroglobulinemia: A clinical perspective in the era of novel therapeutics. Annals of Oncology [Internet]. 2016;27(2):233 - 240. WebsiteAbstract
Waldenström's macroglobulinemia (WM) is a rare, low-grade malignancy with no established standard of care. Rituximab regimens are most commonly used, supported by their efficacy in hematologic malignancies, including WM. A growing number of investigational regimens for WM have been evaluated in phase II clinical trials, including single-agent and combination strategies that include newer-generation monoclonal antibodies (ofatumumab and alemtuzumab), proteasome inhibitors (bortezomib and carfilzomib), immunomodulatory agents (thalidomide and lenalidomide), phosphoinositide 3-kinase/protein kinase B (Akt)/mammalian target of rapamycin pathway inhibitors (everolimus and perifosene), a Bruton's tyrosine kinase inhibitor (ibrutinib), and a histone deacetylase inhibitor (panobinostat). Other novel agents are in early-stage development for WM. International treatment guidelines for WM suggest suitable regimens in the newly diagnosed and relapsed/refractory settings, in accordance with patient age, disease presentation, and efficacy and safety profiles of particular drugs. These factors must be considered when choosing appropriate therapy for individual patients with WM, to maximize response and prolong survival, while minimizing the risk of adverse events. This review article provides a clinical perspective of the modern management of patients with WM, in the context of available trial data for novel regimens and recently updated treatment guidelines. © The Author 2015.
Motti-Stefanidi F, Papathanasiou N, Mastrotheodoros S, Pavlopoulos V. Youth adaptation during the current great economic recession in Greece. In: Positive youth development in global contexts of social and economic change. New York, NY: Routledge; 2016. pp. 98-109. pdf
Καμπερίδου Ειρήνη. ΑΘΛΗΤΙΣΜΟΣ ΚΑΙ ΚΟΙΝΩΝΙΚΗ ΕΝΣΩΜΑΤΩΣΗ. Αναρτημένη Ανακοίνωση (με δίλεπτη προφορική παρουσίαση) στο 2ο Διεθνές Συνέδριο Αθλητικών Επιστημών, Θεσσαλονίκη 25-27 Νοεμβρίου 2016, Κέντρο Δ. 2016.Abstract
Αυτή η εργασία επικεντρώνετε στον κρίσιμο ρόλο του Αθλητισμού στην προώθηση της κοινωνικής ενσωμάτωσης: τη χρήση του αθλητισμού για την αντιμετώπιση κοινωνικών ζητημάτων που σχετίζονται με την εξάλειψη κοινωνικών διακρίσεων, τη διερεύνηση τεχνικών αντιμετώπισης συγκρούσεων και την κοινωνική ένταξη. Αρχικά, στην πρώτη ενότητα, εξετάζεται ο διεθνής διάλογος, πρόσφατα αποτελέσματα ερευνών, για κοινωνικά φαινόμενα όπως ο ρατσισμός και η ξενοφοβία. Παρατηρείτε ότι οι αντιλήψεις για τους μετανάστες και πρόσφυγες (και στη χώρα μας) προκαλούν ανησυχίες για εκείνους που ασχολούνται με την πολυπολιτισμικότητα, το σεβασμό για τα ανθρώπινα δικαιώματα, τη φυλετική και την έμφυλη πολυμορφία, την κοινωνική ισότητα και ισονομία, το νόημα του έθνους, της πατρίδας κ.ά.  Η διεθνής βιβλιογραφία δείχνει ότι όσο ισχυρότερο είναι το κοινωνικό κεφάλαιο των μεταναστών, τόσο περισσότερο διευκολύνεται η κοινωνική τους ένταξη. Τα τελευταία 25 χρόνια η Ελλάδα έχει μετατραπεί σε χώρα μαζικής υποδοχής μεταναστών. Ωστόσο, η αναγνώριση του γεγονότος ότι οι μετανάστες αποτελούν μόνιμη πραγματικότητα στη χώρα μας είναι πρόσφατη και ο δημόσιος διάλογος σχετικά με την κοινωνική και οικονομική τους ενσωμάτωση εξελίσσεται. Στη δεύτερη ενότητα διερευνάται  η χρήση του Αθλητισμού (και της φυσικής αγωγής) ως μέσου για την καλλιέργεια μιας κουλτούρας/παιδείας ειρήνης (peace education) ή ως εργαλείου για την επίλυση συγκρούσεων, ιδιαίτερα ενόψει των αυξανόμενων διαφωνιών και συγκρούσεων που σχετίζονται με τη διαχείριση της προσφυγικής κρίσης— που πλήττει κατά 60% τις γυναίκες και τα παιδιά— για την οποία κρίση η Ευρωπαϊκή Ένωση δεν έχει ολοκληρωμένη πολιτική διαχείρισης. Εντούτοις, αναδεικνύεται ότι ο Αθλητισμός μπορεί να συμβάλλει ουσιαστικά στην κοινωνική ενσωμάτωση των μεταναστών. Πρόσφατη έρευνα της Ευρωπαϊκής Επιτροπής (Σεπτ. 2016)—που συμπεριλαμβάνει 63 «καλές πρακτικές» (good practices)— τεκμηριώνει τη συμβολή του Αθλητισμού στην κοινωνική ενσωμάτωση τον μεταναστών και προσφύγων στην Ευρώπη. 
Καμπερίδου Ειρήνη. Αφηγήσεις Δυτικών Περιηγητριών του 18ου,19ου και αρχές 20ου αιώνα: «Εάν κάθε Τούρκος πασάς είχε μία Ασπασία πόσο θα βελτιωνόταν το γένος των Μ. Εισήγηση στην Ημερίδα: «Η Διάσταση του Φύλου στην Κοινωνική Πολιτική και Κοινωνιολογία», Γ’ Πάνελ. Κέντρο Πολιτισμού και Εκπαίδευσης «ΠΟΛ. 2016;(Social Policy: http://socialpolicy.gr).Abstract
Μάζης Ιωάννης. Γεωπολιτικὴ ἀνάγνωσις τοῦ Συστήματος τῆς ΝΑ Μεσογείου καὶ ἐρντογανικὸς ἀναθεωρητισμὸς. In: Ἐπιστημονικὴ Ἡμερίδα, "Ἑλλάδα -Ρωσσία: 2η χιλιετία φιλικῶν σχέσεων". Ζάππειον Μέγαρον.; 2016.Abstract
Τὸ μεσανατολικὸ γεωπολιτικὸ σύστημα, ἀναδιαρθροῦται μὲ ταχυτάτους ρυθμοὺς καὶ οἱ ἐσωτερικοὶ πυλῶνες ἰσχύος τῶν ἑκάστοτε ὑποσυστημάτων του διαμορφώνουν ἕνα πολύπλοκο δίκτυον ἀνακατανομῆς ἰσχύος ἐπηρεαζόμενομενο μὲ πρωτοφανεῖς τρόπους ἀπὸ τοὺς Πόλους Ἰσχύος τοῦ Ὑπερσυστήματος, ὅπως οἱ ΗΠΑ, ἡ Ρωσσία, ἡ Κίνα, καὶ συγκεκριμένα κράτη-μέλη τῆς Εὐρωπαϊκῆς Ἑνώσεως. Στὸ πλαίσιο αὐτὸ ἄκρως ἐνδιαφέρουσα εἶναι ἡ πλήρης ἀποτυχία τῆς ∆ημοκρατικῆς administration τῆς Οὐάσιγκτων, νὰ δημιουργήσει μίαν «ἰσλαμοδημοκρατικὴ» Τουρκία ἡ ὁποία, μὲ ἐργαλεῖον προβολῆς ἰσχύος τὴν Ὀργάνωση τῶν Ἀδελφῶν Μουσουλμάνων τῆς Αἰγύπτου, θὰ ἐλειτουργοῦσε ὡς ἰσλαμικοῦ τύπου «δημοκρατικὸ» πρότυπον διακυβερνήσεως γιὰ ὅλες τὶς ἰσλαμικοῦ πολιτισμικοῦ ὑποβάθρου χῶρες τῆς Εὐρυτέρας Μέσης Ἀνατολῆς, ἀποτελοῦσα καὶ γεωστρατηγικὸν ἀνάχωμα στὶς Μεσογειακὲς βλέψεις τῆς Ρωσσίας. Η παρούσα ομιλία αναφέρεται στη γεωπολιτικὴ ἀνάγνωση τοῦ γεωπολιτικού συστήματος τῆς ΝΑ Μεσογείου καὶ στον ἐρντογανικὸ ἀναθεωρητισμὸ.
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Μάζης Ιωάννης. Γεωπολιτικὴ στὸν Τέταρτο Πυλῶνα: Πολιτισμός, Ἰδεολογία, Ταὐτότητες. Russia, Greece and the Mediterranean: contemporary geopolitical dynamics and perspectives of peace. 2016.Abstract
Ἡ ἀνάγνωσις τοῦ Γεωπολιτικοῦ Συμπλόκου τοῦ Εὐρω-ἀμερικανικοῦ ∆ιπόλου μὲ Γεωπολιτικὸ Παράγοντα (geopolitical factor) ἐντασσόμενο στὸν σκληρὸ πυρῆνα τοῦ Πολιτισμικοῦ Πυλῶνος (cultural pilar), τὸν παράγοντα τῆς πολιτισμικῆς ταὐτότητος, προσφέρει τὴν εἰκόνα ἑνὸς δυναμικοῦ καὶ μεταλασσόμενου γεωπολιτικοῦ πεδίου (geopolitical field), τὸ ὁποῖον παρουσιάζει κοινὰ ἐθνικο-ταὐτοτικὰ πολιτισμικὰ στοιχεῖα καὶ στρέφεται οὐσιαστικῶς ἐναντίον μιᾶς διεθνοποιημένης τραπεζικῆς πραγματικότητος μὴ βασιζομένης σὲ πραγματικὴ παραγωγὴ ἀλλὰ σὲ ἰδιαίτερα ὑψηλοὺς δεῖκτες μοχλεύσεως καὶ στὴν δημιουργία ἑνὸς Οἰκονομικοῦ ΝΑΤΟ ὑπὸ τὴν ὀνομασίαν τῆς (Transatlantic Trade and Investment Partnership) ΤΤΙP μὲ εὐρωπαῖο χειριστὴ τὴν Γερμανικὴ κυβέρνηση. Το κείμενο, εστιάζει στον τέταρτο γεωπολιτικό πυλώνα ισχύος, αυτόν του πολιτισμού.
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Ελληνική Τέχνη και Αρχαιολογία, 1200-30 π.Χ. 2nd ed. Αθήνα: Καπόν; 2016.
Καμπερίδου Ειρήνη. Ελληνισμός, Υποδούλωση, Τρομοκρατία και Δουλεία: Αφηγήσεις Δυτικών Περιηγητριών (HELLENISM, SUBJUGATION, TERRORISM AND SLAVERY: Personal Accounts by Western Women Travelers). Εισήγηση στο συνέδριο «Αθλητισμός – Πολιτισμός» του Σύνδεσμος Φιλίας Εθνών (Σ.Φ.Ε.) σε συνεργασία με τη Σχολή Επιστήμης Φυσικής Αγωγής & Αθλητισμού (Σ.Ε.Φ.Α.Α.) του Εθνικού και Καποδιστριακού Πανεπιστημίου Αθηνών (Ε.Κ.Π.Α). 2016.Abstract
© Καμπερίδου, Ειρήνη (2016) ). Ελληνισμός, Υποδούλωση, Τρομοκρατία και Δουλεία: Αφηγήσεις Δυτικών Περιηγητριών (HELLENISM, SUBJUGATION, TERRORISM AND SLAVERY: Personal Accounts by Western Women Travelers). Εισήγηση στο συνέδριο «Αθλητισμός – Πολιτισμός» του Συνδέσμου Φιλίας Εθνών (Σ.Φ.Ε.) σε συνεργασία με τη Σχολή Επιστήμης Φυσικής Αγωγής & Αθλητισμού (Σ.Ε.Φ.Α.Α.) του Εθνικού και Καποδιστριακού Πανεπιστημίου Αθηνών (Ε.Κ.Π.Α). Δάφνη, Αθήνα, 28-29 Μαΐου 2016: υπό την Αιγίδα του Εθνικού και Καποδιστριακού Πανεπιστημίου Αθηνών (ΕΚΠΑ). Επίσης, βλ.Proceedings/ Πρακτικά:   Καμπερίδου, Ειρήνη. (2016). Ελληνισμός, Υποδούλωση, Τρομοκρατία και Δουλεία: Αφηγήσεις Δυτικών Περιηγητριών. Πρακτικά- Εισηγήσεις Συνεδρίου «Αθλητισμός-Πολιτισμός» του Σύνδεσμος Φιλίας Εθνών (Σ.Φ.Ε.) σε συνεργασία με τη Σχολή Επιστήμης Φυσικής Αγωγής & Αθλητισμού (Σ.Ε.Φ.Α.Α.) του Εθνικού και Καποδιστριακού Πανεπιστημίου Αθηνών (Ε.Κ.Π.Α). © Copyright - afan.gr - Enfold Theme by Kriesi. [Πρακτικά Συνεδρίου: http://www.afan.gr/afan/%CE%B5%CE%B9%CF%83%CE%B7%CE%B3%CE%AE%CF%83%CE%B5%CE%B9%CF%82-%CF%83%CF%85%CE%BD%CE%B5%CE%B4%CF%81%CE%AF%CE%BF%CF%85-%CE%B1%CE%B8%CE%BB%CE%B7%CF%84%CE%B9%CF%83%CE%BC%CF%8C%CF%82-%CF%80%CE%BF%CE%BB/    
hellenism_subjugation_terrorism_and_slavery.pdf 2._programma_synedriou.pdf 3._poster_synedriou_a3.pdf 1._invitation.jpg.pdf hellenism_subjugation_terrorism_and_slavery_personal_accounts_by_western_women_travelers.pdf female_accounts_on_hellenism_terrorism_and_slavery.pdf athlitismos_politismos_certificate.pdf
Καμπερίδου Ειρήνη. «Επιχειρώντας Αλλιώς» στην εποχή της κρίσης: Η γυναικεία αθλητική επιχειρηματικότητα, ανεκμετάλλευτη πηγή κοινωνικού κεφαλαίου. Εισήγηση στην Ημερίδα "Γυναίκα και Αθλητισμός – Επιχειρώντας Αλλιώς", της Επιτροπής "Γυναίκα και Αθλητισμός" της Κυπριακής Ολυμπιακής Επιτ [Internet]. 2016;(9 Μαρτίου 2016 και ώρα 18.00-19.30). Publisher's VersionAbstract
When citing/ παραπομπή: ©  Καμπερίδου, Ειρήνη (2016). «Επιχειρώντας Αλλιώς» στην εποχή της κρίσης: Η γυναικεία αθλητική επιχειρηματικότητα, ανεκμετάλλευτη πηγή κοινωνικού κεφαλαίου. Εισήγηση στην ημερίδα "Γυναίκα και Αθλητισμός – Επιχειρώντας Αλλιώς" της Κυπριακής Ολυμπιακής Επιτροπής (ΚΟΕ), της Επιτροπής   "Γυναίκα και Αθλητισμός" της ΚΟΕ, υπό την αιγίδα του Υπουργείου Παιδείας και Πολιτισμού, 9 Μαρτίου 2016,  στο Ολυμπιακό Μέγαρο, αίθουσα Ευ Αγωνίζεσθαι, Λευκωσία. DOI: 10.13140/RG.2.1.5054.6322 .... [...]   Σήμερα θα προβούμε σε ένα προβληματισμό ο οποίος έχει να κάνει με τη σχέση του Αθλητισμού και το "Επιχειρείν". Δεν θα επικεντρωθούμε στη γυναικεία υποεκπροσώπηση στον επιχειρηματικό στίβο  γενικότερα,  αλλά στις ανώνυμες ηρωίδες του «αθλητικού επιχειρείν» οι οποίες σταδιακά αυξάνονται. Θα δούμε ότι η Ολυμπιακή επιχειρηματικότητα δεν αποτελεί ανδρικό φαινόμενο, επειδή ο αθλητισμός προάγει  δεξιότητες (και για τα δύο φύλα) που είναι σημαντικά για το «επιχειρείν»,  δηλαδή για την επιχειρηματικότητα και την επαγγελματική επιτυχία. Πρόσφατες έρευνες (ποιοτικές και ποσοτικές)  καθώς και συνεντεύξεις με πρώην αθλήτριες, τεκμηριώνουν ότι  ένας αθλητικός προσανατολισμός, και ειδικά ο ομαδικός αθλητισμός –ή ένα ιστορικό αθλητικής εμπειρίας— αποτελεί χρήσιμο εργαλείο, όσον αφορά στην επιχειρηματικότητα και ειδικά όσον αφορά στην καλλιέργεια και ανάπτυξη ηγετικών δεξιοτήτων, όπως ένα πειθαρχημένο εργασιακό ήθος … … Λέξεις κλειδιά-  Επιχειρηματικότητα (entrepreneur, entrepreneurship), φύλο (gender), αθλητισμός,  φυσική αγωγή, αρχηγία, εξουσία,  ολιστική προσέγγιση: κουλτούρα συνεργασίας,  ηγεσία (εμπνέω, συντονίζω, καθοδηγώ), η πρώτη γυναίκα Ολυμπιακή επιχειρηματίας (Olympic entrepreneur: Alice Milliat) ** http://balla.com.cy/2016/03/10/imerida-ginaikas/ http://24h.com.cy/2016/03/07/hmerida-me-thema-gynaika-kai-athlitismos-epihirontas-allios-dia/
cyprus_olympic_committee_letter_and_invitation.pdf cyprus_olympic_committee_epiheirontas_allios_march_3-2016._final.pdf
Μάζης Ιωάννης. Ἡ Γεωπολιτικὴ τῆς Ὀρθοδοξίας: Τὸ «Εἶναι» καὶ τὸ «Πρέπει». Ἐπιθεώρησις «Πανόραμα» τῆς Ἑλληνορωσσικῆς Λέσχης ∆ιάλογος. 2016.Abstract
Στο παρόν κείμενο εξετάζονται τρεις υποθέσεις: α) η υπόθεσις όπου η Ρωσία κατισχύει δια του Πατριαρχείου της επί του Ορθοδόξου Χριστιανικού κόσμου, γεγονός το οποίο συνεπάγεται τη θραύση του Rimland στον άξονα Βαλκανικής Χερσονήσου-Μεσογείου, β) η υπόθεσις όπου το δίπολο Λονδίνου-Ουάσινγκτον συνεχίζει δια του Οικουμενικού Πατριαρχίου τον έλεγχον της εξόδου της Μόσχας στη Μεσόγειο και γ) η υπόθεσις όπου η Μόσχα και η Ουάσινγκτον συγκλίνουν για την αντιμετώπιση της κινεζικής προβολής ισχύος στην Μεσόγειο και όχι μόνον.
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Κουκουνάρας- Λιάγκης Μάριος. Η εκπαιδευτική αξία των επιτραπέζιων παιχνιδιών στη διδασκαλία στο Γυμνάσιο. Μελέτη περίπτωσης στο πλαίσιο της Θρησκευτικής Εκπαίδευσης. Πρακτικά Εργασιών 1ου Διεθνούς Βιωματικού Συνεδρίου Εφαρμοσμένης Διδακτικής "Καινοτόμες Εφαρμογές στη Διδακτική Πράξη". 2016:446-454. i_ekpaideytiki_axia_ton_epitrapezion_paihnidion_sti_didaskalia_sto_gymnasio._meleti_periptosis_sto_plaisio_tis_thriskeytikis_ekpaideysis.pdf
Kaili H, Spyropoulos V. Η επίδραση της Ελληνικής στην τουρκική ποικιλία της δίγλωσσης στην Ελληνική και Τουρκική μουσουλμανικής κοινότητας της Ρόδου [The impact of Greek on the Turkish variety of the Greek and Turkish bilingual muslim community of Rhodes]. In: Γλωσσική και Κοινοτική Ετερότητα στη Δωδεκάνησο του 20ου Αιώνα [Language and Community Diversity in 20th century Dodecanese]. Athens: Papazisis; 2016. pp. 329-359.
Κουκουνάρας- Λιάγκης Μάριος. Η θέση της Θρησκευτικής Εκπαίδευσης στο ελληνικό σχολείο του 21ου αιώνα: ζητήματα υποχρεωτικότητας, προγράμματος σπουδών και παιδαγωγικής προσέγγισης. 1ο Πανελλήνιο Συνέδριο "Προγράμματα Σπουδών - Σχολικά εγχειρίδια: Από το παρελθόν στο παρόν και το μέλλον". 2016:201-212. _._201.pdf
"Ξεθάβουν τώρα τα αγάλματα": οι αισθητήριες αρχαιολογίες του Γιώργου Σεφέρη. In: Τιμητικός Τόμος για τη Στέλλα Δρούγου. Αθήνα: Ταμείο Αρχαιολογικών Πόρων και Απαλλοτριώσεων; 2016. pp. 348-368. Publisher's VersionAbstract
In June 1946 George Seferis, the eminent Greek poet who was goingto become the Nobel-laureate patriarch of Greek modernist poetry by1963, witnessed the re-excavation of the statues and vases until thenhidden in the vaults of the National Museum in Athens in order toprevent their damage, or looting, by the Germans during the occupation.As he observes the bronze statue of Zeus, a fifth-century BC work thatis still considered one of the masterpieces in the Museum’s collectionand of Greek art at large, the poet fantasizes the god’s lovemaking witha woman whom Seferis himself “would love”, as he unashamedly informsus in his diary from that day. In the paper, I use the concept ofhomosociality in order to explore the ways in which Seferis and manyof his contemporaries view classical antiquity and proceed to deploy itas a bio-political tool in order to claim a centralized role in Greekintellectual and political life. To this end, I re-visit Seferis’s two chief“archaeological” poems –The King of Asine and Engomi – in an effortto investigate the ways in which his sensory archaeologies manifestthemselves.
Kamberidou I. Σύγχρονη Γυναίκα και Άθληση: Συμμετοχή, Προκλήσεις, Προοπτικές. Συμμετοχή στο ΣΥΜΠΟΣΙΟ με τίτλο: «Σύγχρονη Γυναίκα και Άθληση: Συμμετοχή, Προκλήσεις, Προοπτικές», διοργάνωση η Πανελλήνια Ένωση για την Πρ. 2016;(Αριστοτελείου Πανεπιστημίου Θεσσαλονίκης).Abstract
Συμμετοχή στο ΣΥΜΠΟΣΙΟ με τίτλο: «Σύγχρονη Γυναίκα και Άθληση: Συμμετοχή, Προκλήσεις, Προοπτικές» της Πανελλήνιας Ένωσης για την Προώθηση των Γυναικών στον Αθλητισμό και τα Σπορ (ΠΕΠΓΑΣ) της Σχολής Επιστημών Φυσικής Αγωγής και Αθλητισμού του Αριστοτελείου Πανεπιστημίου Θεσσαλονίκης (ΑΠΘ), 25/11/2016, στο ΚΕΔΕΑ/Α.Π.Θ. [Επισυνάπτεται βεβαίωση συμμετοχής] Προσκεκλημένη στο πραναφερόμενο συμπόσιο μετά την προφορική ανακοίνωσή:Καμπερίδου, Ειρήνη. (2016). ΦΥΛΟ ΚΑΙ ΗΓΕΤΙΚΕΣ ΔΕΞΙΟΗΤΕΣ: ΤΟ ΑΘΛΗΤΙΚΟ ΕΠΙΧΕΙΡΕΙΝ. Προφορική Ανακοίνωση στο 2ο Διεθνές Συνέδριο Αθλητικών Επιστημών, Θεσσαλονίκη 25-27 Νοεμβρίου 2016, Κέντρο Διάδοσης Ερευνητικών Αποτελεσμάτων (ΚΕΔΕΑ). Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ). Copy at http://www.tinyurl.com/gtggejd 
women_and_sport_symposium.jpg pepgas.jpg 20161125_131304-1.jpg 20161125_123045-4.jpg 20161125_121711-3.jpg 20161125_115500.jpg pepgas_the_new_generation.jpg rector.jpg
Το Πρόσφατο Μέλλον. Η Κλασική Αρχαιότητα ως Βιοπολιτικό Εργαλείο. Αθήνα: Νεφέλη; 2016. Publisher's Version
Καμπερίδου Ειρήνη. ΦΥΛΟ ΚΑΙ ΗΓΕΤΙΚΕΣ ΔΕΞΙΟΗΤΕΣ: ΤΟ ΑΘΛΗΤΙΚΟ ΕΠΙΧΕΙΡΕΙΝ. Προφορική Ανακοίνωση στο 2ο Διεθνές Συνέδριο Αθλητικών Επιστημών, Θεσσαλονίκη 25-27 Νοεμβρίου 2016, Κέντρο Διάδοσης Ερευνητικών Αποτελεσμάτων (ΚΕΔΕΑ). 2016.Abstract
Ερευνητικά δεδομένα τεκμηριώνουν ότι οι γυναίκες βρίσκονται ένα βήμα μπροστά από τους άντρες αναφορικά με κάποιες δεξιότητες, αποκαλούμενες στο παρελθόν «γυναικείες αρετές» ή «θηλυκές δεξιότητες» τις οποίες υιοθετούν όλο και περισσότεροι άνδρες επιχειρηματίες και στελέχη επιχειρήσεων σήμερα. Έρευνες που αφορούν την παραγωγικότητα δείχνουν ότι εταιρείες που απασχολούν και προωθούν γυναίκες σε ηγετικούς ρόλους εμφανίζουν, κατά μέσο όρο, περισσότερα κέρδη και μεγαλύτερη βιωσιμότητα. Με βάση τα αποτελέσματα μιας σχετικής με το ζήτημα φύλο και επιχειρηματικότητα ποιοτικής έρευνας, η μελέτη αυτή στοχεύει να αναδείξει σημαντικούς συσχετισμούς μεταξύ αθλητικής εμπειρίας και πετυχημένης επιχειρηματικότητας. Ερευνητικά στοιχεία τεκμηριώνουν ότι ένα ιστορικό αθλητικής εμπειρίας, ειδικά η συμμετοχή σε ομαδικά αθλήματα, αποτελεί χρήσιμο εργαλείο όσον αφορά στην καλλιέργεια ηγετικών δεξιοτήτων και στην ανέλιξη επιχειρηματικών δράσεων. Σχετικές έρευνες και συνεντεύξεις που πραγματοποιήθηκαν με εν ενεργεία και πρώην αθλήτριες, πρωταθλήτριες και ολυμπιονίκες πιστοποιούν ότι ο αθλητισμός προάγει δεξιότητες που είναι σημαντικές για το επιχειρείν. Θεωρείται ότι η αθλητική επιχειρηματικότητα αποτελεί ανδρικό φαινόμενο. Ωστόσο, Ελληνίδες αθλήτριες, γυμνάστριες, επιχειρηματίες και ακτιβίστριες που έχουν διαπρέψει στο αθλητικό επιχειρείν, μετά από σειρά συνεντεύξεων, μας παρέχουν πολύτιμες συμβουλές (tips-μέθοδοι-εργαλεία ενδυνάμωσης δεξιοτήτων) για επαγγελματική επιτυχία.     [Proceedings page 68—Πρακτικά 2ου Διεθνούς Συνεδρίου Αθλητικών Επιστημών (ICSS 2016) http://icss2016.web.auth.gr/el/proceedings/icss2016 (σελίδα 68) ]  
gender_and_leadershop_skills-_sport_entrepreneurship.pdf 2nd_int._conference.vevaiosi_omilias_presentation_certification.jpg diploma.jpg sport_entrepreneushp_leadership_certificate.pdf sport_science_conf._thessaloniki_nov._2016.pdf pepgas_nov._2016.pdf
Καμπερίδου Ειρήνη, Kamberidou I. Φύλο και Ηγετικές Δεξιότητες: Γεφυρώνοντας το Έμφυλο Χάσμα (Gender and Leadership Skills: Bridging the Gender Gap). LWB-Leading Women in Business. Κεφάλαιο: Αρθρογραφία Επιφανών Λειτουργών και της ICAP για τη Γυναικεία Επιχειρηματικότητα. 2016:98-99.Abstract
Καμπερίδου, Ειρήνη (2017). Φύλο και Ηγετικές Δεξιότητες: Γεφυρώνοντας το Έμφυλο Χάσμα. LWB-Leading Women in Business, σελ. 98-99.  Κεφάλαιο: Αρθρογραφία Επιφανών Λειτουργών και της ICAP για τη Γυναικεία Επιχειρηματικότητα.  Εκδότης: ΙCAP GROUP Α.Ε. ISSN 2241-4126  [e-book: http://dir.icap.gr/mailimages/e-books/LWB/index.html]    Η διανομή της έκδοσης πραγματοποιήθηκε αρχικά με «ΤΑ ΝΕΑ του Σαββατοκύριακου» στην Αττική (πριν την Πρωτοχρονιά, 30/12/2016) και με τη «ΜΑΚΕΔΟΝΙΑ» (σε CD) στη Θεσσαλονίκη. Επιπρόσθετα, θα μοιραστεί στην επίσημη εκδήλωση “High Heels on High Hills” το 2017 και σε άλλες εκδηλώσεις που διοργανώνει ή συμμετάσχει η ICAP.  Τέλος, θα διανεμηθεί σε φορείς της γυναικείας επιχειρηματικότητας (σε Αττική και Βόρεια Ελλάδα), καθώς και σε 2.000 εταιρείες και ακαδημαϊκά ιδρύματα, ως χρηστικό εργαλείο επί των εργασιών τους............................................. Kamberidou, Irene (2016). Gender and Leadership Skills: Bridging the Gender Gap, pp. 98-99 in LWB-Leading Women in Business. Publisher:  ICAP GROUP A.E. ISSN 2241-4126  [e-book: http://dir.icap.gr/mailimages/e-books/LWB/index.html]  The book circulated, for the first time on Dec. 30, 2016 in Athens with the daily newspaper TA NEA, and as a CD in Thessaloniki with the daily MACEDONIA. It will also be distributed at the 2017 “High Heels on High Hills” and other events and conferences organized by the ICAP Group. To assist researchers, students and entrepreneurs it will also be sent to 2.000 companies and academic institutions throughout Greece.
leading_women_in_business_dec.30_2016_icap_2016.pdf gender_and_leadership_skills._icap_2016.pdf icap_2017.pdf
Mazis I. ВАРИАНТ «БЕШЕНОЙ» ПЕШКИ Кто поставит мат в сложной гроссмейстерской игре на «Великой шахматной доске» Ближнего Востока?. 2016.Abstract
Ответный ход Путина: господин Путин, однако, хочет поставить мат НАТО, и если понадобится, он с готовностью принесет в жертву «сумасшедшего». Это является единственным ходом, доступным Путину: он требует, чтобы Турция максимально быстро вышла из НАТО! В противном случае Эрдоган станет разменной монетой! Дилемма: примет ли или нет господин Эрдоган требование Путина, в конце этой истории его ждет Большой Курдистан. Разница заключается лишь в том, что, если он примет предложение Путина, то обеспечит себе пожизненный отпуск на даче, где-то в Крыму или в Сочи, покинув Турцию навсегда. В противоположном случае, впрочем, его ждет вилла в Саудовской Аравии! Его место почти наверняка займут «запасные политики» вроде Абдуллы Гюля или Ахмета Давутоглу, причем Турция останется инструментом США в «Евразийских Балканах». В обоих случаях обе супердержавы выигрывают: а) 50% территории через создаваемый Большой Курдистан б) развертывание сил на ближний средний восток в) богатые ресурсы г) Сирия получает небольшую долю от выигрыша США, России и Израиля. Партия Путин-США, похоже, заканчивается вничью. Однако нет, поскольку господин Путин серьезно нарастил противостояние юго-восточному крылу НАТО и перераспределил мощности на Ближнем и Среднем Востоке, наращивая несущественное, до недавнего времени, присутствие его сил на этой территории, путем пожертвования «бешеной пешки» в Ближневосточной шахматной игре.
lxviii._variant_beshenoy_peshki_kto_postavit_mat_v_slozhnoy_grossmeysterskoy_igre_na_velikoy_shahmatnoy_doske_blizhnego_vostoka.pdf
2015
Chatziioannou S, Papamichos O, Gamaletsou MN, Georgakopoulos A, Kostomitsopoulos NG, Tseleni-Balafouta S, Papaparaskevas J, Walsh TJ, Pneumaticos SG, Sipsas NV. 18-Fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography scan for monitoring the therapeutic response in experimental Staphylococcus aureus foreign-body osteomyelitis. J Orthop Surg Res. 2015;10:132.Abstract
BACKGROUND: 18-Fluoro-2-deoxy-D-glucose positron emission tomography combined with computed tomography ((18)F-FDG PET/CT) scan is useful for diagnosis of osteoarticular infections. Whether (18)F-FDG PET/CT scanning may be used for therapeutic monitoring is not clear. The objective of this study was to develop (18)F-FDG PET/CT scanning for monitoring therapeutic response to antimicrobials in experimental Staphylococcus aureus osteomyelitis. METHODS: A total of 22 rabbits were studied. In 20 animals, the right tibia was inoculated intraoperatively with S. aureus. Two control animals were inoculated with normal saline. A needle was placed in the tibia as a foreign body. Infection was allowed to develop for 21 days when (18)F-FDG PET/CT was performed, the needle was removed, and bone specimens were cultured to confirm infection. Antimicrobial therapy with daptomycin was initiated in all successfully infected animals for 1, 3, or 6 weeks. Following completion of treatment, a second (18)F-FDG PET/CT was performed, animals were euthanized, and infected tibias were harvested for quantitative cultures and histology. A positive scan was defined as (18)F-FDG signal activity greater in the infected tibia than that of the contralateral non-infected control tibia. Therapeutic response was measured by the change of (18)F-FDG signal activity in the infected tibia. RESULTS: All successfully infected animals (n = 14), with microbiologically and/or histologically confirmed osteomyelitis, had positive (18)F-FDG PET/CT scans, while the two control animals had negative scans despite the presence of the foreign body [mean maximum standardized uptake value (SUVmax) (±SD) values 2.96 (±0.80) vs. 1 (±1.10), respectively, P = 0.04]. In the 14 successfully infected animals, the mean SUVmax was significantly higher in the infected compared to the uninfected tibia (P < 0.0001). A SUVmax of 1.4, when used as a cutoff for infection, yielded a diagnostic accuracy of 93 %. At the end of treatment, successfully treated animals and saline controls had a negative (18)F-FDG PET/CT scan (n = 4), while animals with persistent infection despite treatment (n = 12) had a positive (18)F-FDG PET/CT scan (SUVmax 1.0-3.0) (p < 0.001). SUVmax values were significantly reduced after 42 days of treatment from 3.15 ± 0.5 (day 7) to 1.71 ± 0.37 (day 42) (p = 0.05). CONCLUSIONS: (18)F-FDG PET/CT scan is a sensitive and specific tool in therapeutic monitoring of experimental foreign-body osteomyelitis.
1915-2015: μια ιστορική-επιστημολογική αποτίμηση της θεωρίας της σχετικότητας. Η ΕΦΗΜΕΡΙΔΑ ΤΩΝ ΣΥΝΤΑΚΤΩΝ [Internet]. 2015;(12-13 Δεκεμβρίου):78-79. Publisher's Version
Vlahakos DV, Dalamaga M, Marouga A, Bacharaki D, Drakou A, Dimas C. 1C.09: SERUM RESISTIN AS AN INDEPENDENT BIOMARKER ASSOCIATED WITH ALL-CAUSE AND CARDIOVASCULAR MORTALITY IN ELDERLY HYPERTENSIVE, NON-DIABETIC PATIENTS WITH CHRONIC KIDNEY DISEASE (CKD). J Hypertens. 2015;33 Suppl 1:e11-2.Abstract
OBJECTIVE: Hypertensive patients with CKD present an increased risk for cardiovascular mortality. Among the proteins synthesized and released from adipose tissue, resistin is a cytokine whose physiologic role has been the subject of much research and controversy. We and others have demonstrated that serum resistin levels are higher in patients with CKD and correlate directly with inflammatory markers, including TNF-α and hsCRP. Since inflammation has been consistently linked to atherosclerosis, death, and cardiovascular (CV) events, our goal was to investigate the interaction between resistin levels and long term all-cause and CV mortality in elderly non-obese and non-diabetic with hypertension. DESIGN AND METHOD: We studied 80 patients (52 men/28 women) 70.9 ± 8.6 years of age with hypertension and CKD. Exclusion criteria was obesity and diabetes mellitus, active infection, acute illness, chronic inflammatory disease or cancer, and immunosuppresive, anti-inflammatory or anti-lipidemic drugs. Demographic data, clinical information and blood samples were collected prospectively. The patients were observed for 5 years. RESULTS: During the follow-up 28 of 80 (35%) patients died: 16 (57%) deaths due to CV events and 12 (43%) of other causes. Patients who died were older and had higher DBP, compared to survivors, but had no differences in BMI, smoking, SBP and HR. Deceased patients had higher WBC, hsCRP, BUN, creatinine, cystatin C, phosphate, magnesium and potassium levels and lower eGFR, Hct/Hg, T3, T4, total cholesterol, LDL-C, albumin and sodium levels compared to survivors. No significant differences in platelet count, TNF-α, fibrinogen, oxLDL, ADMA, HgA1C and HOMA-index were revealed between the groups. eceased patients had significantly higher resistin levels than survivors at baseline (p = 0.025), but adiponectin, visfatin and leptin did not differ between the two groups. Five variables, namely resistin, sodium, cholesterol, T3 and WBC remained significantly associated with survival and were used in the multivariate Cox regression analysis, which revealed that only resisitin, cholesterol and WBC maintained their discriminatory ability, as independent predictors of mortality both by forward and backward stepwise analysis. CONCLUSIONS: Elevated serum resistin was a significant independent biomarker of CV and all-cause mortality in elderly, non-diabetic CKD patients with hypertension.
Cox P, Foster A, Hargitai B, Konstantinidou A, Marton T. 26. The Spectrum of Cardiac Pathology in Fetal Hydrops due to Noonan syndrome. Pediatric & Developmental Pathology. 2015;18(2):e48.
Vrontaki E, Melagraki G, Afantitis A, Tsantili-Kakoulidou A, Mavromoustakos T. 3D quantitative structure - Activity relationships (3D - QSAR): A short overview. Pharmakeftiki [Internet]. 2015;27(4):126 - 137. Website
Stefanou DT, Bamias A, Episkopou H, Kyrtopoulos SA, Likka M, Kalampokas T, Photiou S, Gavalas N, Sfikakis PP, Dimopoulos MA, et al. Aberrant dna damage response pathways may predict the outcome of platinum chemotherapy in ovarian cancer. PLoS ONE [Internet]. 2015;10(2). WebsiteAbstract
Ovarian carcinoma (OC) is the most lethal gynecological malignancy. Despite the advances in the treatment of OC with combinatorial regimens, including surgery and platinum-based chemotherapy, patients generally exhibit poor prognosis due to high chemotherapy resistance. Herein, we tested the hypothesis that DNA damage response (DDR) pathways are involved in resistance of OC patients to platinum chemotherapy. Selected DDR signals were evaluated in two human ovarian carcinoma cell lines, one sensitive (A2780) and one resistant (A2780/C30) to platinum treatment as well as in peripheral blood mononuclear cells (PBMCs) from OC patients, sensitive (n = 7) or resistant (n = 4) to subsequent chemotherapy. PBMCs from healthy volunteers (n = 9) were studied in parallel. DNA damage was evaluated by immunofluorescence ãH2AX staining and comet assay. Higher levels of intrinsic DNA damage were found in A2780 than in A2780/C30 cells. Moreover, the intrinsic DNA damage levels were significantly higher in OC patients relative to healthy volunteers, as well as in platinum-sensitive patients relative to platinum-resistant ones (all P <0.05). Following carboplatin treatment, A2780 cells showed lower DNA repair efficiency than A2780/ C30 cells. Also, following carboplatin treatment of PBMCs ex vivo , the DNA repair efficiency was significantly higher in healthy volunteers than in platinum-resistant patients and lowest in platinum-sensitive ones (t1/2 for loss of ãH2AX foci: 2.7± 0.5h, 8.8±1.9h and 15.4±3.2h, respectively; using comet assay, t1/2 of platinum-induced damage repair: 4.8±1.4h, 12.9±1.9h and 21.4±2.6h, respectively; all P<0.03). Additionally, the carboplatin-induced apoptosis rate was higher in A2780 than in A2780/C30 cells. In PBMCs, apoptosis rates were inversely correlated with DNA repair efficiencies of these cells, being significantly higher in plati-num-sensitive than in platinum-resistant patients and lowest in healthy volunteers (all P< 0.05). We conclude that perturbations of DNA repair pathways as measured in PBMCs from OC patients correlate with the drug sensitivity of these cells and reflect the individualized response to platinum-based chemotherapy. © 2015 Stefanou et al.
Dalamaga M, Christodoulatos GS. Adiponectin as a biomarker linking obesity and adiposopathy to hematologic malignancies. Horm Mol Biol Clin Investig. 2015;23(1):5-20.Abstract
Higher body mass index and adiposopathy have been associated with increased risk of hematologic malignancies such as leukemia, multiple myeloma, myeloproliferative disorders, Hodgkin's and non-Hodgkin's lymphoma, and myelodysplastic syndromes. Adiponectin is a multimeric protein of the white adipose tissue presenting anti-inflammatory, insulin-sensitizing, anti-atherogenic, cardioprotective, and anti-neoplastic properties. Its anti-neoplastic actions are manifested via two mechanisms: (i) direct action on tumor cells by enhancing receptor-mediated signaling pathways and (ii) indirect action by regulating inflammatory responses, influencing cancer angiogenesis, and modulating insulin sensitivity at the target tissue site. In the bone marrow milieu, adiponectin and its main receptors are expressed by the majority of bone marrow stromal cell populations influencing hematopoietic stem cells function. Adiponectin may represent a molecular mediator relating adiposopathy with leukemogenesis and myelomagenesis. Several epidemiological studies conducted to date relate hypoadiponectinemia to the risk of myeloid-derived hematopoietic cancer and multiple myeloma. Adiponectin may be a promising biomarker with potential diagnostic and prognostic utility in determining the likelihood of myeloma and leukemia progression in certain cohorts of monoclonal gammopathy of undetermined significance patients and in myeloid hematologic malignancies, respectively. This review summarizes experimental and epidemiologic data regarding the role of adiponectin in hematologic malignancies in the context of adiposopathy. Enhancement of endogenous adiponectin, adiponectin replacement, or manipulation of adiponectin receptor sensitivity may be an attractive goal for prevention and an effective therapeutic strategy against hematopoietic cancer, specifically in overweight/obese individuals. Further studies are required to elucidate the role of the bone marrow microenvironment adiponectin in complex interactions involved in preleukemic and leukemic states.
Vrachatis DA, Papaioannou TG, Vavuranakis M, Tousoulis D. Advances in intra-arterial counterpulsation: The role of in vitro studies. Archives of Hellenic Medicine [Internet]. 2015;32(4):433 - 440. Website
Nastos P, Matzarakis A, Nikolopoulou M, Lin T-P. Advances in urban biometeorology 2014. Advances in Meteorology [Internet]. 2015;2015. Website
Psaltopoulou T, Sergentanis TN, Sergentanis IN, Karadimitris A, Terpos E, Dimopoulos MA. Alcohol intake, alcoholic beverage type and multiple myeloma risk: A meta-analysis of 26 observational studies. Leukemia and Lymphoma [Internet]. 2015;56(5):1484 - 1501. WebsiteAbstract
This meta-analysis aimed to examine the association between alcohol consumption and multiple myeloma (MM) risk. Eligible publications were sought in PubMed to 31 December 2013. Separate analyses were performed by study design, gender, alcoholic beverages and levels of consumption. Sixteen case-control studies (3921 cases and 19 594 controls) and 10 cohort studies (3167 incident cases in total cohort of 2 557 649 subjects) were eligible. Ever consumption of alcohol was associated with reduced MM risk (pooled relative risk [RR] = 0.88, 95% confidence interval [CI]: 0.79-0.99) and especially consumption of wine correlated with reduced MM risk (pooled RR = 0.77, 95% CI: 0.67-0.89 for ever drinkers). MM risk was not affected by beer or liquor intake. A protective association was observed among females (pooled RR = 0.79, 95% CI: 0.69-0.89 for ever drinkers), whereas the association among males seemed null. In conclusion, contrary to most solid tumors, alcohol intake may confer protection in terms of MM risk among females, with wine being particularly beneficial. © 2014 Informa UK, Ltd.
Tsabouri S, Bleta AG, Nastos PT, Priftis KN. Ambient environmental risk factors for childhood wheezing illness. Frontiers in Bioscience - Elite [Internet]. 2015;7E(3):447 - 468. WebsiteAbstract
It is a great consensus in the scientific community that environmental factors, such as weather conditions and ambient air pollution, have vital impacts on respiratory diseases. Further, these factors imply the potential to have many significant impacts on aeroallergens, and therefore related diseases such as asthma and allergic rhinitis. The impacts are more pronounced in sensitive groups of population, such as children and elderly, living in urbanized areas. Over the last three decades, studies have shown changes in production, dispersion and allergen content of pollen and spores, which may be region- and species-specific. In addition, these changes may have been influenced by air pollutants interacting directly with pollen. It is not easy to evaluate the impact of climate change and air pollution on the prevalence of asthma in general and on the timing of asthma exacerbations. However, the global rise in asthma prevalence and severity suggests that air pollution and climate changes could be contributing. The objective of this review is to summarize the environmental impacts on pulmonary diseases in children based on recent literature over the world. © 2015, Frontiers in Bioscience. All rights reserved.
Giralt S, Garderet L, Durie B, Cook G, Gahrton G, Bruno B, Hari P, Lokhorst H, McCarthy P, Krishnan A, et al. American Society of Blood and Marrow Transplantation, European Society of Blood and Marrow Transplantation, Blood and Marrow Transplant Clinical Trials Network, and International Myeloma Working Group Consensus Conference on Salvage Hematopoietic Cell Tra. Biology of Blood and Marrow Transplantation [Internet]. 2015;21(12):2039 - 2051. WebsiteAbstract
In contrast to the upfront setting in which the role of high-dose therapy with autologous hematopoietic cell transplantation (HCT) as consolidation of a first remission in patients with multiple myeloma (MM) is well established, the role of high-dose therapy with autologous or allogeneic HCT has not been extensively studied in MM patients relapsing after primary therapy. The International Myeloma Working Group together with the Blood and Marrow Transplant Clinical Trials Network, the American Society of Blood and Marrow Transplantation, and the European Society of Blood and Marrow Transplantation convened a meeting of MM experts to: (1) summarize current knowledge regarding the role of autologous or allogeneic HCT in MM patients progressing after primary therapy, (2) propose guidelines for the use of salvage HCT in MM, (3) identify knowledge gaps, (4) propose a research agenda, and (5) develop a collaborative initiative to move the research agenda forward. After reviewing the available data, the expert committee came to the following consensus statement for salvage autologous HCT: (1) In transplantation-eligible patients relapsing after primary therapy that did NOT include an autologous HCT, high-dose therapy with HCT as part of salvage therapy should be considered standard; (2) High-dose therapy and autologous HCT should be considered appropriate therapy for any patients relapsing after primary therapy that includes an autologous HCT with initial remission duration of more than 18 months; (3) High-dose therapy and autologous HCT can be used as a bridging strategy to allogeneic HCT; (4) The role of postsalvage HCT maintenance needs to be explored in the context of well-designed prospective trials that should include new agents, such as monoclonal antibodies, immune-modulating agents, and oral proteasome inhibitors; (5) Autologous HCT consolidation should be explored as a strategy to develop novel conditioning regimens or post-HCT strategies in patients with short (less than 18 months remissions) after primary therapy; and (6) Prospective randomized trials need to be performed to define the role of salvage autologous HCT in patients with MM relapsing after primary therapy comparing it to "best non-HCT" therapy. The expert committee also underscored the importance of collecting enough hematopoietic stem cells to perform 2 transplantations early in the course of the disease. Regarding allogeneic HCT, the expert committee agreed on the following consensus statements: (1) Allogeneic HCT should be considered appropriate therapy for any eligible patient with early relapse (less than 24 months) after primary therapy that included an autologous HCT and/or high-risk features (ie, cytogenetics, extramedullary disease, plasma cell leukemia, or high lactate dehydrogenase); (2) Allogeneic HCT should be performed in the context of a clinical trial if possible; (3) The role of postallogeneic HCT maintenance therapy needs to be explored in the context of well-designed prospective trials; and (4) Prospective randomized trials need to be performed to define the role salvage allogeneic HCT in patients with MM relapsing after primary therapy. © 2015 American Society for Blood and Marrow Transplantation.
Lantzouraki, D.Z. SZGĆSHPVJPG. Antiradical-antimicrobial activity and phenolic profile of pomegranate (Punica granatum L.) juices from different cultivars: A comparative study. RSC Advances [Internet]. 2015;5:2602-2614. Website
Kastritis E, Dimopoulos MA. Appraising myc involvement in high risk myeloma. Leukemia and Lymphoma [Internet]. 2015;56(3):551 - 552. Website
Kopanias K, MacGinnis J, Ur J. Archaeological Projects in the Kurdistan Region in Iraq. Α Gazeteer. Erbil: General Directorate of Antiquities in the Kurdistan Region in Iraq; 2015. Website
Zagouri F, Sergentanis TN, Azim, H.A. J, Chrysikos D, Dimopoulos M-A, Psaltopoulou T. Aromatase inhibitors in male breast cancer: a pooled analysis. Breast Cancer Research and Treatment [Internet]. 2015;151(1):141 - 147. WebsiteAbstract
Although several studies have shown the efficacy of third-generation aromatase inhibitors (AIs) in women with breast cancer, the role of such molecules remains elusive in male breast cancer patients. It is also unknown whether the addition of gonadotropin-releasing hormone (GnRH) analogues to AIs would be a superior strategy or not. This pooled analysis was conducted in accordance with the PRISMA guidelines. All studies that examined the efficacy of AIs in metastatic male breast cancer were considered eligible. Overall, 15 studies (105 cases) were eligible for this pooled analysis. The mean age of the study sample was 62.8 years. ER status was positive in all eligible cases. AI was given as first line in 61.5 % of cases. GnRH analogue was co-administered with AI in 37.1 % of cases (n = 39). CR, PR, SD and PD were achieved in 5.7, 23.8, 37.2 and 33.3 % of cases, respectively. The median PFS and OS were equal to 10.0 and 39.0 months, respectively. Co-administration of GnRH analogues was associated with more than threefold increase in rates of clinical benefit (OR = 3.37, 95 % CI 1.30–8.73) but did not seem to correlate with better PFS or OS. No statistically significant associations between the examined outcomes and the other parameters were noted. Available data suggest that AIs may potentially play a promising role in the optimal therapeutic strategy for metastatic male breast cancer patients. Especially, co-administration of AI with a GnRH analogue seems to increase the rate of clinical benefit and could be more effective, warranting further consideration. © 2015, Springer Science+Business Media New York.
Chrysostomou S. Assessment in the music classroom: Inherent challenges and the PISA problematic (in Spanish). Revista International de Education Musical. 2015;3:23-30.
Neokosmidis I, Avaritsiotis N, Ventoura Z, Varoutas D. Assessment of the gap and (non-) Internet users evolution based on population biology dynamics. Telecommunications Policy. 2015;39:14–37.
Dautzenberg MJD, Wekesa AN, Gniadkowski M, Antoniadou A, Giamarellou H, Petrikkos GL, Skiada A, Brun-Buisson C, Bonten MJM, Derde LPG. The association between colonization with carbapenemase-producing enterobacteriaceae and overall ICU mortality: an observational cohort study. Crit Care Med. 2015;43(6):1170-7.Abstract
OBJECTIVES: Infections caused by carbapenemase-producing Enterobacteriaceae are increasing worldwide, especially in ICUs, and have been associated with high mortality rates. However, unequivocally demonstrating causality of such infections to death is difficult in critically ill patients because of potential confounding and competing events. Here, we quantified the effects of carbapenemase-producing Enterobacteriaceae carriage on patient outcome in two Greek ICUs with carbapenemase-producing Enterobacteriaceae endemicity. DESIGN: Observational cohort study. SETTING: Two ICUs with carbapenemase-producing Enterobacteriaceae endemicity. PATIENTS: Patients admitted to the ICU with an expected length of ICU stay of at least 3 days were included. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Carbapenemase-producing Enterobacteriaceae colonization was established through screening in perineum swabs obtained at admission and twice weekly and inoculated on chromogenic plates. Detection of carbapenemases was performed phenotypically, with confirmation by polymerase chain reaction. Risk factors for ICU mortality were evaluated using cause-specific hazard ratios and subdistribution hazard ratios, with carbapenemase-producing Enterobacteriaceae colonization as time-varying covariate. One thousand seven patients were included, 36 (3.6%) were colonized at admission, and 96 (9.5%) acquired carbapenemase-producing Enterobacteriaceae colonization during ICU stay, and 301 (29.9%) died in ICU. Of 132 carbapenemase-producing Enterobacteriaceae isolates, 125 (94.7%) were Klebsiella pneumoniae and 74 harbored K. pneumoniae carbapenemase (56.1%), 54 metallo-β-lactamase (40.9%), and four both (3.0%). Carbapenemase-producing Enterobacteriaceae colonization was associated with a statistically significant increase of the subdistribution hazard ratio for ICU mortality (subdistribution hazard ratio=1.79; 95% CI, 1.31-2.43), not explained by an increased daily hazard of dying (cause-specific hazard ratio for death=1.02; 95% CI, 0.74-1.41), but by an increased length of stay (cause-specific hazard ratio for discharge alive=0.73; 95% CI, 0.51-0.94). Other risk factors in the subdistribution hazard model were Acute Physiology and Chronic Health Evaluation II score (subdistribution hazard ratio=1.13; 95% CI, 1.11-1.15), female gender (subdistribution hazard ratio=1.29; 95% CI, 1.02-1.62), presence of solid tumor (subdistribution hazard ratio=1.54; 95% CI, 1.15-2.06), hematopoietic malignancy (subdistribution hazard ratio=1.61; 95% CI, 1.04-2.51), and immunodeficiency (subdistribution hazard ratio=1.59; 95% CI, 1.11-2.27). CONCLUSIONS: Patients colonized with carbapenemase-producing Enterobacteriaceae have on average a 1.79 times higher hazard of dying in ICU than noncolonized patients, primarily because of an increased length of stay.
Nikolaou V, Papadavid E, Ekonomidi A, Dalamaga M, Marinos L, Stratigos A, Papadaki T, Antoniou C. Association of clinicopathological characteristics with secondary neoplastic lymphoproliferative disorders in patients with lymphomatoid papulosis. Leuk Lymphoma. 2015;56(5):1303-7.Abstract
Lymphomatoid papulosis (LyP) refers to an indolent cutaneous lymphoma. The association of prognostic clinicopathological risk factors with a second hematologic malignancy has not yet been determined. We investigated the prognostic effect of clinicopathological characteristics on the occurrence of a second lymphoma, as well as the first-line treatment, in 24 patients diagnosed with LyP using logistic regression models. We showed that lymphoma occurrence was associated with a lower mean age at onset of LyP symptoms, histological types B and C, head-located LyP lesions and a higher frequency of LyP recurrences. In multivariate analyses, histologic type A was associated with a lower risk of second lymphoma (odds ratio [OR] = 0.12, 95% confidence interval [CI] 0.014-0.98; p = 0.045) adjusting for age of LyP first symptomatology, and an important increased lymphoma-free survival rate (long-rank test; p = 0.06). Clinicopathological characteristics are important in defining the clearance or persistence of LyP lesions and may predict the occurrence of a second lymphoma.
Zhang Y, Kollias G, Argyris AA, Papaioannou TG, Tountas C, Konstantonis GD, Achimastos A, Blacher J, Safar ME, Sfikakis PP, et al. Association of left ventricular diastolic dysfunction with 24-h aortic ambulatory blood pressure: The SAFAR study. Journal of Human Hypertension [Internet]. 2015;29(7):442 - 448. Website
Karailias A, Katsiva C, Lagaki V, Kanellakopoulos A, Mertzimekis TJ, Kafantaris F-CA, Godelitsas A. The Athens Mobile γ-Spectrometry System (AMESOS). In: Hellenic Nuclear Physics Society; 2015. Website
Michaelides S, Nastos P, Flocas H. Atmospheric Processes in the Mediterranean. Atmospheric Research [Internet]. 2015;152:1 - 3. Website
Madesis I, Dimitriou A, Laoutaris A, Lagoyannis A, Axiotis M, Mertzimekis T, Andrianis M, Harissopulos S, Benis EP, Sulik B, et al. Atomic Physics with Accelerators: Projectile Electron Spectroscopy (APAPES). In: Journal of Physics: Conference Series. Vol. 583. ; 2015. pp. 012014.Abstract
The new research initiative APAPES (http://apapes.physics.uoc.gr/) has already established a new experimental station with a beam line dedicated for atomic collisions physics research, at the 5 MV TANDEM accelerator of the National Research Centre "Demokritos" in Athens, Greece. A complete zero-degree Auger projectile spectroscopy (ZAPS) apparatus has been put together to perform high resolution studies of electrons emitted in ion-atom collisions. A single stage hemispherical spectrometer with a 2-dimensional Position Sensitive Detector (PSD) combined with a doubly-differentially pumped gas target will be used to perform a systematic isoelectronic investigation of K-Auger spectra emitted from collisions of preexcited and ground state He-like ions with gas targets using novel techniques. Our intention is to provide a more thorough understanding of cascade feeding of the 1s2s2p 4 P metastable states produced by electron capture in collisions of He-like ions with gas targets and further elucidate their role in the non-statistical production of excited three-electron 1s2s2p states by electron capture, recently a field of conflicting interpretations awaiting further resolution. At the moment, the apparatus is being completed and the spectrometer will soon be fully operational. Here we present the project progress and the recent high resolution spectrum obtained in collisions of 12 MeV C 4+ on a Neon gas target.
Marsellou EG, Bassiakos YC. Bankrupt Households and Economic Crisis. Evidence from the Greek Courts. Journal of Consumer Policy. 2015:1–22.
Patruno S, Triantaphyllou, M., Erba, E., Dimiza, M., Bottini, C., Kaminski MA. The Barremian and Aptian stepwise development of the "Oceanic Anoxic Event 1a" (OAE 1a) crisis: integrated benthic and planktic high-resolution palaeoecology along the Gorgo a Cebara stratotype section (Umbria-Marche Basin, Italy). Palaeogeography, Palaeoclimatology, Palaeoecology [Internet]. 2015;424:147–182. Publisher's VersionAbstract
The Barremian and Aptianwere times of global plate reconfiguration and profound changes in the ocean–climate system, culminating in the worldwide deposition of lower Aptian black shale layers (OAE 1a). Based on high resolution lithostratigraphic and micropaleontological analyses, precursor conditions and timing of the anoxia are here reconstructed along a 33.06 m thick section in the proposed Barremian/Aptian boundary GSSP stratotype at Gorgo a Cerbara (Umbria–Marche Basin, Italy). A non-uniform history of benthic foraminiferal diversification is interrupted by the Selli Level (= OAE 1a) and by three turnover points for both benthic and planktic organisms, each highlighted by prominent breaks in lithology and outcrop morphology. The first two points, at ~1.1 Myr and ~20–50 kyr prior to the onset of the OAE 1a, correspond respectively to the nannoconid (=bathypelagic calcareous nannofossils) ‘decline’ and ‘crisis’ events, and separate: (a) pelagic limestone/chert-claystone lithological cycles of the uppermost Maiolica Formation, showing frequencies reminiscent of orbital eccentricity and containing an oligotrophic Barremian benthic and planktic assemblage, dominated by k-selected nannoconids and Rhizammina; (b) greenish-grey cherty marls of the lowermost Marne a Fucoidi Formation, associated to declining sedimentation rates and eutrophic early Aptian assemblages dominated by radiolarians and lituolid benthic foraminifera; and (c) anoxic radiolarites and shales of the carbonate-free Selli Level. High magnitude and frequency assemblage fluctuations occur between the nannoconid crisis (~25 cm below the lowermost OAE 1a black shale layer) and the Selli Level base, with suggestions of bottom-water acidification. At ~800 kyr after the OAE 1a end, a third turnover point in the basal reddish member of the Marne a Fucoidi highlights ‘middle’ Aptian assemblages characterized by a bloom of early macroperforate planktic foraminifera (Hedbergella spp.) and appearances of new benthic species, marking a shift towards better oxygenation. OAE 1a oxygen and pelagic carbonate factory crises are here suggested to have been step-wise and linked to global warming conditions.
Antonarakou, A., Kontakiotis, G., Mortyn, P.G., Drinia, H., Sprovieri, M., Besiou, E., Tripsanas E. Biotic and geochemical (δ18Ο, δ13C, Mg/Ca, Ba/Ca) responses of Globigerinoides ruber morphotypes to upper water column variations during the last deglaciation, Gulf of Mexico. Geochimica et Cosmochimica Acta [Internet]. 2015;170:69-93. Publisher's Version
Karamanou M, Papaioannou TG, Tsoucalas G, Tousoulis D, Stefanadis C, Androutsos G. Blood Pressure Measurement: Lessons Learned from Our Ancestors. Current Pharmaceutical Design [Internet]. 2015;21(6):700 - 704. Website
Papaioannou TG, Vavuranakis M, Tousoulis D. Brachial Systolic Blood Pressure Fails to Predict Short-Term Outcome in Patients With Acute Ischemic Stroke: What About Central Systolic Pressure?. American journal of hypertension [Internet]. 2015;28(9):1180. Website
Papaioannou TG, Vavuranakis M, Tousoulis D. Brachial Systolic Blood Pressure Fails to Predict Short-Term Outcome in Patients With Acute Ischemic Stroke: What About Central Systolic Pressure?. American Journal of Hypertension [Internet]. 2015;28(9):1180. Website
Kollatos N, Manta S, Dimopoulou A, Parmenopoulou V, Triantakonstanti VV, Kellici T, Mavromoustakos T, Schols D, Komiotis D. Branched-chain sugar nucleosides: Stereocontrolled synthesis and bioevaluation of novel 3′-C-trifluoromethyl and 3′-C-methyl pyranonucleosides. Carbohydrate Research [Internet]. 2015;407:170 - 178. Website
Vavouranakis G, Bourbou C. Breaking up the past: patterns of fragmentation in Early and Middle Bronze Age tholos tomb contexts in Crete. In: Harrell K, Driessen J THRAVSMA. Contextualising the intentional destruction of objects in the Bronze Age Aegean and Cyprus (Aegis 9). Louvain-la-Neuve: Presses universitaires de Louvain; 2015. pp. 167-196.
Metaxas EI, Balis E, Papaparaskevas J, Spanakis N, Tatsis G, Tsakris A. Bronchiectasis exacerbations: The role of atypical bacteria, respiratory syncytial virus and pulmonary function tests. Can Respir J. 2015;22(3):163-6.Abstract
BACKGROUND: Aside from the known role of common bacteria, there is a paucity of data regarding the possible role of atypical bacteria and viruses in exacerbations of non-cystic fibrosis bronchiectasis. OBJECTIVE: To explore the possible role of atypical bacteria (namely, Mycoplasma pneumoniae and Chlamydophila pneumoniae) and respiratory syncytial virus (RSV) as causative agents of bronchiectasis exacerbations. METHODS: A cohort of 33 patients was studied over a two-year period (one year follow-up for each patient). Polymerase chain reaction for the detection of M pneumoniae, C pneumoniae and RSV in bronchoalveolar lavage samples were performed during all visits. Antibody titres (immunoglobulin [Ig]M and IgG) against the aforementioned pathogens were also measured. In addition, cultures for common bacteria and mycobacteria were performed from the bronchoalveolar lavage samples. RESULTS: Fifteen patients experienced a total of 19 exacerbations during the study period. Although RSV was detected by polymerase chain reaction during stable visits in four patients, it was never detected during an exacerbation. M pneumoniae and C pneumoniae were never detected at stable visits or during exacerbations. IgM antibody titres for these three pathogens were negative in all patient visits. CONCLUSIONS: Atypical pathogens and RSV did not appear to be causative agents of bronchiectasis exacerbations.
Alexandrou A, Armeni E, Kaparos G, Rizos D, Tsoka E, Deligeoroglou E, Creatsa M, Augoulea A, Diamantis T, Lambrinoudaki I. Bsm1 vitamin D receptor polymorphism and calcium homeostasis following bariatric surgery. Journal of Investigative Surgery. 2015;28(1):8 - 17.Abstract
Copyright © 2015 Informa Healthcare USA, Inc. Purpose/Aim: To evaluate the association between the Bsm1 vitamin D receptor polymorphism and the calcium-vitamin D-parathormone axis following bariatric surgery. Materials and Methods: This cross-sectional study included 86 morbidly obese patients, who underwent either gastric bypass or sleeve gastrectomy, with a mean follow-up of four years. Calcium metabolism indices and bone turnover markers were assessed according to the presence of secondary hyperparathyroidism and the Bsm1 vitamin D receptor genotypes. Results: Secondary hyperparathyroidism (42.2% of sample) was associated with lower levels of 25hydroxyvitamin D and elevated markers of bone turnover. In subjects without secondary hyperparathyroidism, presence of the unfavorable B allele resulted in higher levels of parathormone (Bb and BB vs. bb genotype: 50.3 ± 8.2 pg/dl vs. 44.4 ± 10.7 pg/dl, p = .011, adjusted for weight loss, baseline body mass index, 25hydroxyvitamin D, surgical procedure, and duration after surgery). In the whole sample, patients bearing the unfavorable B allele exhibited lower weight loss, a parameter that was negatively associated with markers of bone resorption. Conclusions: Secondary hyperparathyroidism is highly prevalent after bariatric surgery. Bsm1 vitamin D receptor polymorphism may have an effect in early stages of calcium metabolism imbalance, while no association is detected in patients who have already developed secondary hyperparathyroidism. Moreover, vitamin D receptor polymorphism is associated with post-surgery weight loss, a process related to bone turnover.
Dimopoulos MA, Sonneveld P, Siegel D, Palumbo A, San-Miguel J. Carfilzomib and pomalidomide in patients with relapsed and/or refractory multiple myeloma with baseline risk factors. Annals of Oncology [Internet]. 2015;26(11):2247 - 2256. WebsiteAbstract
While survival times have increased over the last decade, most patients with multiple myeloma (MM) eventually relapse and become refractory to therapy. The treatment of patients with relapsed and/or refractory MM is frequently further complicated by the presence of pre-existing comorbidities that arise from an advanced disease state and of toxicities stemming from prior antimyeloma treatment. Carfilzomib and pomalidomide have recently been approved for the treatment of patients with relapsed and refractory MM. While these agents represent important additions to the available treatment options, the identification of patients who may best benefit from the use of each of therapy is still being investigated. A number of patient-related and disease-related factors may impact treatment efficacy and/or tolerability, and the clinical presentation and medical history of each patient must be carefully considered to optimize treatment. Here, we review results from carfilzomib and pomalidomide clinical trials in patients with relapsed and/or refractory MM who also have baseline comorbidities or treatment-induced or disease-induced complications (including the presence of renal impairment, cardiac risk factors, peripheral neuropathy, or high-risk chromosomal abnormalities) to evaluate the safety and efficacy of the two agents in these difficult-to-treat patients and to provide treatment recommendations specific to each scenario. © The Author 2015. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved.
Stewart AK, Rajkumar SV, Dimopoulos MA, Masszi T, Špicka I, Oriol A, Hajek R, Rosinol L, Siegel DS, Mihaylov GG, et al. Carfilzomib, lenalidomide, and dexamethasone for relapsed multiple myeloma. New England Journal of Medicine [Internet]. 2015;372(2):142 - 152. WebsiteAbstract
Background Lenalidomide plus dexamethasone is a reference treatment for relapsed multiple myeloma. The combination of the proteasome inhibitor carfilzomib with lenalidomide and dexamethasone has shown efficacy in a phase 1 and 2 study in relapsed multiple myeloma. Methods We randomly assigned 792 patients with relapsed multiple myeloma to carfilzomib with lenalidomide and dexamethasone (carfilzomib group) or lenalidomide and dexamethasone alone (control group). The primary end point was progression-free survival. Results Progression-free survival was significantly improved with carfilzomib (median, 26.3 months, vs. 17.6 months in the control group; hazard ratio for progression or death, 0.69; 95% confidence interval [CI], 0.57 to 0.83; P = 0.0001). The median overall survival was not reached in either group at the interim analysis. The Kaplan-Meier 24-month overall survival rates were 73.3% and 65.0% in the carfilzomib and control groups, respectively (hazard ratio for death, 0.79; 95% CI, 0.63 to 0.99; P = 0.04). The rates of overall response (partial response or better) were 87.1% and 66.7% in the carfilzomib and control groups, respectively (P<0.001; 31.8% and 9.3% of patients in the respective groups had a complete response or better; 14.1% and 4.3% had a stringent complete response). Adverse events of grade 3 or higher were reported in 83.7% and 80.7% of patients in the carfilzomib and control groups, respectively; 15.3% and 17.7% of patients discontinued treatment owing to adverse events. Patients in the carfilzomib group reported superior health-related quality of life. Conclusions In patients with relapsed multiple myeloma, the addition of carfilzomib to lenalidomide and dexamethasone resulted in significantly improved progression-free survival at the interim analysis and had a favorable risk-benefit profile. (Funded by Onyx Pharmaceuticals; ClinicalTrials.gov number, NCT01080391.) Copyright © 2015 Massachusetts Medical Society. All rights reserved.
Dalla V, Bassiakos Y, Meintanis SG. Characteristic Function‐based Inference for GARCH Models with Heavy‐tailed Innovations. Communications in Statistics - Simulation and Computation [Internet]. 2015:0-0. Publisher's VersionAbstract
We consider estimation and goodness–of–fit tests in GARCH models with innovations following a heavy–tailed and possibly asymmetric distribution. Although the method is fairly general and applies to GARCH models with arbitrary innovation distribution, we consider as special instances the stable Paretian, the variance gamma and the normal inverse Gaussian distribution. Exploiting the simple structure of the characteristic function of these distributions we propose minimum distance estimation based on the empirical characteristic function of properly standardized GARCH–residuals. The finite–sample results presented facilitate comparison with existing methods, while the new procedures are also applied to real data from the financial market.
Papageorgiou F, Godelitsas A, Xanthos S, Voulgaris N, Nastos P, Mertzimekis TJ, Argyraki A, Katsantonis G. Characterization of phosphogypsum deposited in Schistos remediated waste site (Piraeus, Greece). In: Uranium-Past and Future Challenges. Springer; 2015. pp. 271–280.
Papageorgiou F, Godelitsas A, Xanthos S, Voulgaris N, Nastos P, Mertzimekis TJ, Argyraki A, Katsantonis G. Characterization of phosphogypsum deposited in Schistos remediated waste site (Piraeus, Greece). In: Merkel BJ, Arab A Uranium - Past and Future Challenges. Springer International Publishing; 2015. pp. 271-280.Abstract
Abstract The operation of a phosphate fertilizer industry in Drapetsona, near Piraeus port (Greece), resulted in the deposition of 10 million tons of phosphogypsum (PG) into an old limestone quarry, in the period 1979-1989. The whole deposit has been recently remediated using geomembranes and thick soil cover with vegetation. The purpose of the present study was to characterize representative samples of that phosphogypsum, using diffraction (powder-XRD), microscopic (SEM-EDS), analytical (ICP-MS), and spectroscopic techniques (High-resolution γ-ray spectrometry and XRF). The material contains crystalline gypsum (CaSO4.2H2O) and Ca-Si-Al-S-F (chukhrovite-type/meniaylovite) phases. The natural radioactivity is mainly due to the $^{238}$U series and particularly $^{226}$Ra (average: 462 Bq/kg), which is relatively low compared to PG from the rest of the world. Furthermore, leaching experiments using local (Attica) rainwater, together with ICP-MS, were performed to assess the potential release of elements in the environment.
Kritikos N, Vallianatou T, Dotsikas Y, Tsantili-Kakoulidou A. Chemometrics-chem(O)informatics as a tool in quantitative structure – Property and structure – Activity relationships, qspr & qsar. Pharmakeftiki [Internet]. 2015;27:73-100. Website
Lambrinoudaki I, Bouziou G, Armeni E, Spyropoulou A, Koundi K, Rizos D, Augoulea A, Alexandrou A, Creatsa M, Panoulis C, et al. Circulating androgens are associated with mood disturbances in young postmenopausal women. Climacteric. 2015;18(2):205 - 213.Abstract
© 2015 International Menopause Society. Objectives We aimed to evaluate the association between circulating androgens and the presence of psychological symptoms in a sample of healthy middle-aged women. Methods Psychological and depressive symptoms were evaluated in a total of 207 postmenopausal women, using the Symptom Checklist-90-R (SCL-90R) and the Zung Depression Scale, respectively. We investigated the associations between the SCL-90R and Zung Scale scores, and anthropometric, lifestyle parameters, as well as serum levels of androgens. Results The free androgen index was positively associated with scores of depression (b-coefficient ± standard error (SE) = 0.2 ± 0.2, p = 0.040), anxiety (b-coefficient ± SE = 0.2 ± 0.2, p = 0.028), anger/aggressiveness (b-coefficient ± SE = 0.3 ± 0.2, p = 0.026), psychotism (b-coefficient ± SE = 0.3 ± 0.1, p = 0.013) as well as with the global index of the SCL-90R scale (b-coefficient ± SE = 0.2 ± 0.1, p = 0.036), while sex hormone binding globulin was negatively associated with depression (b-coefficient ± SE = -0.2 ± 0.0, p = 0.046) and psychotism (b-coefficient ± SE = -0.2 ± 0.0, p = 0.047). These associations were independent of vasomotor symptomatology, smoking and hormone therapy intake and were more pronounced in younger (≤ 5.5 years) compared to older postmenopausal women. Levels of dehydroepiandrosterone sulfate were positively associated with interpersonal sensitivity (b-coefficient ± SE = 0.3 ± 0.3, p = 0.042), psychotism (b-coefficient ± SE = 0.4 ± 0.2, p = 0.007) and the global index (b-coefficient ± SE = 0.3 ± 0.2, p = 0.040) in women < 5.5 years postmenopausal. No significant associations were observed between the Zung or Greene Scale scores and levels of androgens. Conclusion Higher androgenicity was positively associated with symptoms of anxiety and depression in postmenopausal women. These associations were stronger in women closer to the menopausal transition, a finding which may suggest that menopause rather than aging may mediate the association of androgens with mood disorders.
Philandras CM, Nastos PT, Kapsomenakis IN, Repapis CC. Climatology of upper air temperature in the Eastern Mediterranean region. Atmospheric Research [Internet]. 2015;152:29 - 42. WebsiteAbstract
The goal of this study is to contribute to the climatology of upper air temperature in the Mediterranean region, during the period 1965-2011. For this purpose, both radiosonde recordings and gridded reanalysis datasets of upper air temperature from National Center for Environmental Prediction-National Center for Atmospheric Research (NCEP-NCAR) were used for seven barometric levels at 850. hPa, 700. hPa, 500. hPa, 300. hPa, 200. hPa, 150. hPa and 100. hPa. Trends and variability of upper air temperature were analyzed on annual and seasonal basis. Further, the impact of atmospheric circulation, by means of correlation between upper air temperature at different barometric levels and specific climatic indices such as Mediterranean Oscillation Index (MOI), North Sea Caspian Pattern Index (NCPI) and North Atlantic Oscillation Index (NAOI), was also quantified. Our findings have given evidence that air temperature is increasing at a higher rate in lower/middle troposphere against upper, and this is very likely due to increasing greenhouse gas concentrations. © 2013 Elsevier B.V.
Dimopoulos MA, Terpos E, Niesvizky R, Palumbo A. Clinical characteristics of patients with relapsed multiple myeloma q. Cancer Treatment Reviews [Internet]. 2015;41(10):827 - 835. WebsiteAbstract
Although survival outcomes have improved over the last decade for patients with multiple myeloma (MM), few patients remain free of disease and most inevitably relapse. Selecting a treatment for patients with relapsed MM is challenging given the number and diversity of regimens patients may have previously received, which can affect subsequent therapeutic choices. Importantly, a number of patient- and disease-related factors can also have an effect on treatment choice, treatment efficacy, and tolerability; thus, an understanding of the heterogeneity of patients in the setting of relapsed MM is important for appropriate treatment selection. Here, we review select patient and disease characteristics reported in key interventional and observational studies in relapsed MM (including age, sex, race, and the presence of high-risk disease, renal impairment, or peripheral neuropathy at baseline) to examine common and disparate features of patients with relapsed MM. As therapeutic regimens can have varying efficacy and/or tolerability in patients depending on these factors, we also provide treatment recommendations for patients with select baseline characteristics. © 2015 The Authors.
Loukas YL, Thodi G, Molou E, Georgiou V, Dotsikas Y, Schulpis KH. Clinical diagnostic Next-Generation sequencing: The case of CFTR carrier screening. Scandinavian Journal of Clinical and Laboratory Investigation [Internet]. 2015;75(5):374 - 381. Website
Malinverno E, Triantaphyllou M, Dimiza M. Coccolithophore assemblage distribution along a temperate to polar gradient in the West Pacific sector of the Southern Ocean (January 2005). Micropaleontology [Internet]. 2015;61(6):489-506. Publisher's VersionAbstract
We document surface coccolithophore species composition along a N-S transect from New Zealand to the Ross Sea, across the fronts of the Antarctic Circumpolar Current. Emiliania huxleyi is the most abundant coccolithophore species throughout, with high concentration in the northernmost samples, in the Polar Frontal Zone and at the Polar Front. Three E. huxleyi morphotypes, A, B/C and O were recognized and show different biogeographic distributions along the investigated transect. Coccolithophore distribution appears to be strongly controlled by the location of oceanographic fronts, with minor species (Calcidiscus leptoporus, Syracosphaera spp., Acanthoica quattrospina, Umbellosphaera tenuis, Corisphaera strigilis and other holococcolithophores) largely restricted to the northern Sub-Antarctic Zone, only showing minor occurrence in the southern Sub-Antarctic Zone and being very rare in the Polar Frontal Zone. Our data confirm previous findings and add new information on the biogeography of minor coccolithophore species in relation with oceanographic features. Overall, integration with previous data on the southern extent distribution of E. huxleyi showed no significant temporal shifts in the polar dynamic perspective of the species since early observations.
Triantaphyllou M, Karatsolis B-T, Dimiza M, Malinverno E, Cerino F, Psarra S, Jordan R, Young J. Coccolithophore combination coccospheres from the NE Mediterranean Sea: new evidence and taxonomic revisions. Micropaleontology [Internet]. 2015;61(6):457-472. Publisher's VersionAbstract
Numerous specimens of coccolithophore combination coccospheres in water samples collected from the North Aegean and Tyrrhenian (Mediterranean Sea) have been photographed using the scanning electron microscope.As a consequence a series of taxonomic revisions are proposed, in which the names of the heterococcolithophores and holococcolithophores involved in the same life-cycle are synonymized. This has resulted in synonymizing the genus Coronosphaera with Syracosphaera and establishing one new combination; Syracosphaera arethusae (Kamptner 1941) comb. nov.
Sadeghpour A, Rappolt M, Ntountaniotis D, Chatzigeorgiou P, Viras K, Megariotis G, Papadopoulos MG, Siapi E, Mali G, Mavromoustakos T. Comparative study of interactions of aliskiren and AT<inf>1</inf> receptor antagonists with lipid bilayers. Biochimica et Biophysica Acta - Biomembranes [Internet]. 2015;1848(4):984 - 994. Website
Kourlaba G, Dimopoulos MA, Pectasides D, Skarlos DV, Gogas H, Pentheroudakis G, Koutras A, Fountzilas G, Maniadakis N. Comparison of filgrastim and pegfilgrastim to prevent neutropenia and maintain dose intensity of adjuvant chemotherapy in patients with breast cancer. Supportive Care in Cancer [Internet]. 2015;23(7):2045 - 2051. WebsiteAbstract
Purpose: The aim of this study was to compare the effectiveness of prophylactic single fixed dose of pegfilgrastim and daily administration of filgrastim on febrile neutropenia (FN), severe neutropenia, treatment delay, and dose reduction in patients with breast cancer receiving dose-dense adjuvant chemotherapy. Methods: A retrospective cohort study with 1058 breast cancer patients matched by age and chemotherapy was conducted. The primary endpoints were FN, severe (grade 3, 4) neutropenia, dose reduction (>10 % reduction of the dose planned), and treatment delay (dose given more than 2 days later). Results: Eighteen episodes of FN (3.4 %) in the filgrastim group and 23 (4.3 %) in the pegfilgrastim group (p = 0.500) were recorded. More than half of the total episodes (27/41) occurred during the first 4 cycles of treatment. Patients who received filgrastim were almost three times more likely to experience a severe neutropenia episode and were significantly more likely to experience a dose reduction (18.5 %) compared to those who received pegfilgrastim (10.8 %) (p < 0.001). The percentage of patients, who received their planned dose on time, was significantly lower in patients receiving filgrastim (58 %) compared to those receiving pegfilgrastim (72.4 %, p < 0.001). Conclusions: No significant difference was detected on FN rate between daily administration of filgrastim and single administration of pegfilgrastim. However, patients receiving pegfilgrastim had a significantly lower rate of severe neutropenia, as well as dose reduction and treatment delay, thus, achieving a higher dose density. © 2014, Springer-Verlag Berlin Heidelberg.
Souglis A a, Bogdanis GC a, Giannopoulou I a, Papadopoulos C b, c Apostolidis N a. Comparison of Inflammatory Responses and Muscle Damage Indices Following a Soccer, Basketball, Volleyball and Handball Game at an Elite Competitive Level. Research in Sports Medicine [Internet]. 2015;23:59-72. WebsiteAbstract
Inflammatory responses and muscle damage indices were compared between four popular team sports at an elite level. Seventy two male elite players of four team sports: soccer (n = 18), basketball (n = 18), volleyball (n = 18) and handball (n = 18), completed an official match, while 18 non-athletes served as controls. Blood samples were drawn before, immediately after and 13 and 37 h post-match. Soccer produced the greatest increase in inflammatory cytokines (tumor necrosis factor-alpha and interleukin-6), which were increased by 3-4 fold immediately after the game, as well as in C-reactive protein, which was increased by threefold in the next morning after the match. Metabolic stress (urea, ammonia and cortisol) and muscle damage indices (creatine kinase and lactate dehydrogenase) were also higher after soccer, with creatine kinase responses being almost 2-3 times higher than the other sports. Volleyball showed the smallest increase in inflammation and muscle damage markers compared with the other three sports. © 2014 © 2014 Taylor & Francis.
Souglis AG a, Papapanagiotou A b, Bogdanis GC a, Travlos AK c, Apostolidis NG a, Geladas ND a. Comparison of inflammatory responses to a soccer match between elite male and female players. Journal of Strength and Conditioning Research [Internet]. 2015;29:1227-1233. WebsiteAbstract
The aim of this study was to compare the inflammatory responses between male and female soccer players for a period of 48 hours after an official match. Blood samples were taken from 83 subjects (22 elite male and 21 elite female soccer players and 20 male and 20 female inactive individuals) in the morning of the game day, immediately after the soccer game and 24 and 48 hours after the match. Average relative exercise intensity during the match was similar in male and female players, as indicated by mean heart rate that was 86.9 ± 4.3 and 85.6 ± 2.3% of maximal heart rate (p 0.23), respectively. Interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) increased 2- to 4-fold above resting values, peaking immediately after the match. C-reactive protein (CRP) and creatine kinase peaked 24 hours after the match. Interleukin 6, CRP, and creatine kinase responses were similar in male and female players, but the peak in TNF-α was 18% higher in male players. Interleukin 6, TNF-α, and CRP at rest were lower in male and female players compared with the control subjects, suggesting a protective effect of regular exercise training regarding the inflammatory profile. The results of this study show that a soccer match induces significant inflammatory responses in both male and female players, with only TNF-α peak values being lower in females. Because of the effects of inflammatory responses on performance and health of the players, it is suggested that coaches and trainers should adjust exercise training programs after a match to promote recovery and protect the athletes' health. © 2015 National Strength and Conditioning Association.
Souglis, A.G.a PBTAGA b GC. Comparison of inflammatory responses to a soccer match between elite male and female players. Journal of Strength and Conditioning Research [Internet]. 2015;29:1227-1233. WebsiteAbstract
The aim of this study was to compare the inflammatory responses between male and female soccer players for a period of 48 hours after an official match. Blood samples were taken from 83 subjects (22 elite male and 21 elite female soccer players and 20 male and 20 female inactive individuals) in the morning of the game day, immediately after the soccer game and 24 and 48 hours after the match. Average relative exercise intensity during the match was similar in male and female players, as indicated by mean heart rate that was 86.9 ± 4.3 and 85.6 ± 2.3% of maximal heart rate (p 0.23), respectively. Interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) increased 2- to 4-fold above resting values, peaking immediately after the match. C-reactive protein (CRP) and creatine kinase peaked 24 hours after the match. Interleukin 6, CRP, and creatine kinase responses were similar in male and female players, but the peak in TNF-α was 18% higher in male players. Interleukin 6, TNF-α, and CRP at rest were lower in male and female players compared with the control subjects, suggesting a protective effect of regular exercise training regarding the inflammatory profile. The results of this study show that a soccer match induces significant inflammatory responses in both male and female players, with only TNF-α peak values being lower in females. Because of the effects of inflammatory responses on performance and health of the players, it is suggested that coaches and trainers should adjust exercise training programs after a match to promote recovery and protect the athletes' health. © 2015 National Strength and Conditioning Association.
Kastritis E, Kyrtsonis M-C, Morel P, Gavriatopoulou M, Hatjiharissi E, Symeonidis AS, Vassou A, Repousis P, Delimpasi S, Sioni A, et al. Competing risk survival analysis in patients with symptomatic waldenström macroglobulinemia: The impact of disease unrelated mortality and of rituximab-based primary therapy. Haematologica [Internet]. 2015;100(11):e448 - e449. Website
Dimiza M, Triantaphyllou M, Malinverno E, Psarra S, Karatsolis B-T, Mara P, Lagaria A, Gogou A. The composition and distribution of living coccolithophores in the Aegean Sea (NE Mediterranean). Micropaleontology [Internet]. 2015;61(6):521-540. Publisher's VersionAbstract
This study presents the species composition of living coccolithophore communities in the Aegean Sea (northeastern Mediterranean), investigating their spatial and temporal variations in various environmental conditions from mesotrophic to ultra- oligotrophic regions. Coccolithophores of the photic zone in the Aegean Sea are relatively diverse (65 heterococcolithophores and 34 holococcolithophores) and dominated mostly by Emiliania huxleyi, Syracosphaera spp., Rhabdosphaeraceae and holococcolithophores. Hierarchical classification using R-mode cluster analysis distinguished five coccolithophore groups: Group Ia (Emiliania huxleyi, Syracosphaera molischii and Syracosphaera ossa) prevails in the high cell density and low diversity assemblages during the winter and early spring, when low temperatures and high nutrient concentrations are prevailing. Particularly in the north Aegean, E. huxleyi is dominating the upper photic zone being affected by the Black Sea Water inflow and the associated control on the water column stratification. Group Ib (Florisphaera profunda, Algirosphaera robusta, Syracosphaera anthos and Syracosphaera lamina) becomes important in the lower photic zone, making up the typical deep assemblages, whereas Group Ic (mainly Helicosphaera carteri and Gephyrocapsa oceanica) implies an opportunistic behavior in distinctly polluted neritic regions. Group IIa (Rhabdosphaera clavigera, Syracosphaera protrudens, Syracosphaera halldalii and numerous holococcolithophores) dominates the late spring-early autumn low cell density and high diversity assemblages, mainly in the thermally-stratified south Aegean and/or shallow, coastal environments with normal/ oligotrophic conditions, while Group IIb (Umbellosphaera tenuis and Syracosphaera pulchra) dominates the coccolithophore assemblages mainly during the early autumn in the north Aegean, thus reflecting the influence of Levantine Intermediate Water masses in the middle-lower photic zone. Our results suggest that abundance and variability in Aegean Sea coccolithophore assemblages are primarily controlled by surface water circulation and the associated water column stratification,with the sea temperature gradient affecting species composition.
Arabatzis T, Nersessian NJ. Concepts Out of Theoretical Contexts. In: T. Arabatzis, J. Renn, A. Simões (eds.), Relocating the History of Science: Essays in Honor of Kostas Gavroglu. Dordrecht: Springer; 2015. pp. 225-238. Publisher's VersionAbstract
In this paper we take as our point of departure Kostas Gavroglu and Yorgos Goudaroulis’s insight that, in the process of describing and explaining novel phenomena, scientific concepts are taken “out of” their original theoretical context, acquire additional meaning, and become relatively autonomous. We first present their account of how concepts are re-contextualized and, in the process, extended and/or revised. We then situate it within its philosophical context, and discuss how it broke with a long-standing philosophical tradition about concepts. Finally, we argue that recent developments in science studies can flesh out and vindicate the “concepts out of contexts” idea. In particular, historical and philosophical studies of experimentation and cognitive-historical studies of modeling practices indicate various ways in which concepts are formed and articulated “out of context”.
Sifianou M. Conceptualizing politeness in Greek: Evidence from Twitter corpora. Journal of Pragmatics. 2015;86:25–30.
Kenourgios, D. DD. Contagion of the Global Financial Crisis and the real economy: A regional analysis. Economic Modelling [Internet]. 2015;44:283-293. Website
Palumbo A, Gay F, Cavallo F, Raimondo FD, Larocca A, Hardan I, Nagler A, Petrucci MT, Hajek R, Pezzatti S, et al. Continuous therapy versus fixed duration of therapy in patients with newly diagnosed multiple myeloma. Journal of Clinical Oncology [Internet]. 2015;33(30):3459 - 3466. WebsiteAbstract
Purpose: Continuous therapy (CT) prolongs progression-free survival 1 (PFS1; time from random assignment until the first progression or death), but chemotherapy-resistant relapse may negatively impact overall survival (OS). Progression-free survival 2 (PFS2; time from random assignment until the second progression or death) may represent an additional tool to estimate outcome. This study evaluates the benefit of novel agent-based CT versus fixed duration of therapy (FDT) in patients with newly diagnosed myeloma. Methods: We included patients enrolled onto three phase III trials that randomly assigned patients to novel agent-based CT versus FDT. Primary analyses were restricted to the intent-to-treat population eligible for CT (patients progression free and alive at 1 year after random assignment). Primary end points were PFS1, PFS2, and OS. All hazard ratios (HRs) and 95% CIs were adjusted for several potential confounders using Cox models. Results: In the pooled analysis of the three trials, 604 patients were randomly assigned to CT and 614 were assigned to FDT. Median follow-up was 52 months. In the intent-to-treat CT population, CT (n = 417), compared with FDT (n = 410), significantly improved PFS1 (median, 32 v 16 months, respectively; HR, 0.47; 95% CI, 0.40 to 0.56; P < .001), PFS2 (median, 55 v 40 months, respectively; HR, 0.61; 95% CI, 0.50 to 0.75; P < .001), and OS (4-year OS, 69% v 60%, respectively; HR, 0.69; 95% CI, 0.54 to 0.88; P = .003). Conclusion: In this pooled analysis, CT significantly improved PFS1, PFS2, and OS. The improvement in PFS2 suggests that the benefit reported during first remission is not cancelled by a shorter second remission. PFS2 is a valuable end point to estimate long-term clinical benefit and should be included in future trials. Copyright © 2015 American Society of Clinical Oncology. All rights reserved.
Patsantaras N. Cosmopolitanism: An alternative way of thinking in the Contemporary Olympics. EJSS. European Journal for Sport and Society. 2015;12:215.
Dimopoulos MA, Richardson PG, Moreau P, Anderson KC. Current treatment landscape for relapsed and/or refractory multiple myeloma. Nature Reviews Clinical Oncology [Internet]. 2015;12(1):42 - 54. WebsiteAbstract
Recent developments in the treatment of multiple myeloma have led to improvements in response rates and to increased survival; however, relapse is inevitable in almost all patients. Recurrence of myeloma is typically more aggressive with each relapse, leading to the development of treatment-refractory disease, which is associated with a shorter survival. Several phase II and III trials have demonstrated the efficacy of recently approved agents in the setting of relapsed and/or refractory multiple myeloma, including immunomodulatory agents, such as lenalidomide and pomalidomide, and proteasome inhibitors, such as bortezomib and carfilzomib. Currently, however, there is no standard treatment for patients with relapsed and/or refractory disease. This Review discusses the current treatment landscape for patients with relapsed and/or refractory multiple myeloma and highlights disease-related and patient-related factors - such as pre-existing comorbidities or toxicities - that are important considerations for clinicians when selecting an appropriate treatment regimen.
Dimopoulos MA, Weise KC, Song KW, Delforge M, Karlin L, Goldschmidt H, Moreau P, Banos A, Oriol A, Garderet L, et al. Cytogenetics and long-term survival of patients with refractory or relapsed and refractory multiple myeloma treated with pomalidomide and low-dose dexamethasone. Haematologica [Internet]. 2015;100(10):1327 - 1333. WebsiteAbstract
Patients with refractory or relapsed and refractory multiple myeloma who no longer receive benefit from novel agents have limited treatment options and short expected survival. del(17p) and t(4;14) are correlated with shortened survival. The phase 3 MM-003 trial demonstrated significant progression-free and overall survival benefits from treatment with pomalidomide plus low-dose dexamethasone compared to high-dose dexamethasone among patients in whom bortezomib and lenalidomide treatment had failed. At an updated median follow-up of 15.4 months, the progression-free survival was 4.0 versus 1.9 months (HR, 0.50; P<0.001), and median overall survival was 13.1 versus 8.1 months (HR, 0.72; P=0.009). Pomalidomide plus low-dose dexamethasone, compared with highdose dexamethasone, improved progression-free survival in patients with del(17p) (4.6 versus 1.1 months; HR, 0.34; P <0.001), t(4;14) (2.8 versus 1.9 months; HR, 0.49; P=0.028), and in standard-risk patients (4.2 versus 2.3 months; HR, 0.55; P<0.001). Although the majority of patients treated with high-dose dexamethasone took pomalidomide after discontinuation, the overall survival of patients treated with pomalidomide plus low-dose dexamethasone or highdose dexamethasone was 12.6 versus 7.7 months (HR, 0.45; P=0.008) in patients with del(17p), 7.5 versus 4.9 months (HR, 1.12; P=0.761) in those with t(4;14), and 14.0 versus 9.0 months (HR, 0.85; P=0.380) in standard-risk subjects. The overall response rate was higher in patients treated with pomalidomide plus low-dose dexamethasone than in those treated with high-dose dexamethasone both among standard-risk patients (35.2% versus 9.7%) and those with del(17p) (31.8% versus 4.3%), whereas it was similar in patients with t(4;14) (15.9% versus 13.3%). The safety of pomalidomide plus low-dose dexamethasone was consistent with initial reports. In conclusion, pomalidomide plus low-dose dexamethasone is efficacious in patients with relapsed/refractory multiple myeloma and del(17p) and/or t(4;14). This study is registered at ClinicalTrials.gov as NCT01311687 and with EudraCT as 2010-019820-30. © 2015 Ferrata Storti Foundation.
Balios D, Eriotis N, Missiakoulis S, Vasiliou D. Delisted versus voluntary delisted versus remain listed: an ordered analysis. Applied Economics Letters. 2015;22(1):66-70.Abstract
Public companies were classified according to whether they remain public or they have been delisted voluntarily or not. Proxy variables were separated according to accounting and/or market information and an ordered polytomous logit model was then applied in order to estimate the probability of delisting. Companies with poor liquidity, high leverage, big stock price decline and lack of interest from investors’ point of view (low trading activity) have higher probability to be delisted, voluntarily or not.
Paramithiotis, S. ASDPAKE. Detection of DNA sequences originating from GMOs in milk and dairy products commercially available in Greece. Agro Food Industry Hi-Tech [Internet]. 2015;26:52-56. Website
Alexandrou A, Tsoka E, Armeni E, Rizos D, Diamantis T, Augoulea A, Panoulis C, Liakakos T, Lambrinoudaki I. Determinants of secondary hyperparathyroidism in bariatric patients after roux-en-y gastric bypass or sleeve gastrectomy: A pilot study. International Journal of Endocrinology. 2015;2015.Abstract
© 2015 Andreas Alexandrou et al. Objective. Nutritional deficiencies are common after bariatric surgery. We aimed to assess the prevalence and possible predictors of secondary hyperparathyroidism (SHPT) in bariatric patients. Methods. A total of 95 patients who had undergone Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG) were assessed after a median of 3 years after surgery. Anthropometric/demographic and weight-loss parameters were compared according to the presence of SHPT, independently for men/premenopausal women and postmenopausal women. Results. SHPT was highly prevalent (men/premenopausal women, 52.1%; postmenopausal women, 31.9%). Among men/premenopausal women, multivariate analysis indicated that SHPT was predicted by (a) 25-hydroxyvitamin D levels (Exp(B) = 0.869, P-value = 0.037), independently of age, sex, smoking; (b) calcium (Exp(B) = 0.159, P-value = 0.033) and smoking, independently of age and sex; (c) magnesium (Exp(B) = 0.026, P-value = 0.046) and smoking, independently of age and sex. Among postmenopausal women, SHPT was predicted by menopausal age independently of age, smoking, and levels of 25-hydroxyvitamin D or calcium. The development of SHPT was not associated with the type of surgery. Conclusions. RYGB and SG exhibited similar effects regarding the regulation of the hypothalamus-pituitary-parathyroid axis after surgery. Vitamin D status and menopausal age appear to determine SHPT on the long term. SHPT should be sought and vigorously treated with calcium and vitamin D supplementation.
Kastritis E, Gavriatopoulou M, Kyrtsonis M-C, Roussou M, Hadjiharissi E, Symeonidis A, Repoussis P, Michalis E, Delimpasi S, Tsatalas K, et al. Dexamethasone, rituximab, and cyclophosphamide as primary treatment of Waldenström macroglobulinemia: Final analysis of a phase 2 study. Blood [Internet]. 2015;126(11):1392 - 1394. Website
Digital textbooks and the politics of content enrichment in EFL textbooks
Mitsikopoulou B. Digital textbooks and the politics of content enrichment in EFL textbooks. In: Curdt-Christiansen XL, Weninger C Language, Ideology and Education: The Politics of Textbooks in Language Education. London: Routledge; 2015. pp. 404-430. Publisher's Version digital_textbooks_politics_of_enrichment.pdf
Zagouri F, Liakou P, Bartsch R, Peccatori FA, Tsigginou A, Dimitrakakis C, Zografos GC, Dimopoulos M-A, Azim HA. Discrepancies between ESMO and NCCN breast cancer guidelines: An appraisal. Breast [Internet]. 2015;24(4):513 - 523. WebsiteAbstract
An ever growing number of medical organizations, societies, working groups and governmental agencies issue algorithms i.e. guidelines, of decision making flowcharts in diagnosis and treatment in a variety of diseases. In the field of evidence-based diagnosis and treatment of breast cancer, a large number of guidelines are available both from medical associations and national health departments. Among the most appreciated and utilized comprehensive guides is the European Society for Medical Oncology (ESMO) Breast Cancer Guidelines and from the other side of the Atlantic the National Comprehensive Cancer Network (NCCN) Guidelines in Breast Cancer. Although there is much concordance between the guidelines from these two organizations, it is intriguing to locate their discrepancies also. The aim of this report is to present a number of different points between ESMO and NCCN in the whole spectrum of breast cancer management, from prevention and diagnosis to treatment and follow up. This systematic review was performed in accordance with the PRISMA guidelines using a predefined search strategy and summarizes in detail, the differences between ESMO and NCCN guidelines regarding genetic risk evaluation and screening, surgery, chemotherapy, endocrine treatment, targeted biological agents, radiotherapy, pregnancy and fertility and follow-up. © 2015 Elsevier Ltd.
The discursive construction of the recent European economic crisis in two political magazines
Mitsikopoulou B, Lykou C. The discursive construction of the recent European economic crisis in two political magazines. On the Horizon [Internet]. 2015;23(3):190-201. Publisher's Version mitsikopoulou_lykou_2015_on_the_horizon.pdf
Botsou F, Godelitsas A, Kaberi H, Mertzimekis TJ, Goettlicher J, Steininger R, Scoullos M. Distribution and partitioning of major and trace elements in pyrite-bearing sediments of a Mediterranean coastal lagoon. Chemie der Erde. 2015;75:–.Abstract
Abstract The formation of iron sulphide minerals exerts significant control on the behaviour of trace elements in sediments. In this study, three short sediment cores, retrieved from the remote Antinioti lagoon (N. Kerkyra Island, \{NW\} Greece), are investigated concerning the solid phase composition, distribution, and partitioning of major (Al, Fe) and trace elements (Cd, Cu, Mn, Pb, and Zn). According to $^{210}$Pb, the sediments sampled correspond to depositions of the last 120 years. The high amounts of organic carbon (4.1–27.5%) result in the formation of Fe sulphides, predominantly pyrite, already at the surface sediment layers. Pyrite morphologies include monocrystals, polyframboids, and complex FeS–FeS$_2$ aggregates. According to synchrotron-generated micro X-ray fluorescence and X-ray absorption near-edge structure spectra, authigenically formed, Mn-containing, Fe(III) oxyhydroxides (goethite type) co-exist with pyrite in the sediments studied. Microscopic techniques evidence the formation of galena, sphalerite and CuS, whereas sequential extractions show that carbonates are important hosts for Mn, Cd, and Zn. However, significant percentages of non-lattice held elements are bound to Fe/Mn oxyhydroxides that resist reductive dissolution (on average 60% of Pb, 46% of Cd, 43% of Zn and 9% of Cu). The partitioning pattern changes drastically in the deeper part of the core that is influenced by freshwater inputs. In these sediments, the post-depositional pyritization mechanism, illustrated by overgrowths of Fe monosulphides on pre-existing pyrite grains, results in relatively high degree of pyritization that reaches 49% for Cd, 66% for Cu, 32% for Zn and 7% for Pb.
I Z. . Journal of Aquaculture Research and Development [Internet]. 2015;6(5):332. j_aquac_res_development.pdf
Kenourgios D, Papadamou S, Dimitriou D. . Finance Research Letters [Internet]. 2015;14:128-134.
This paper examines the effects of quantitative easing (QE) announcements by the European Central Bank (ECB), the Bank of England (BoE) and the Bank of Japan (BoJ) on the intraday volatility transmissions among EUR, GBP and JPY. The empirical results indicate: (i) an increased volatility transmission from EUR to JPY and GBP around the ECB announcements, and from GBP to EUR over the BoE announcements, (ii) the ECB and BoE announcements significantly increase the volatility of EUR and JPY, and (iii) a ‘‘calming down’’ impact on the volatility of EUR and GBP from the BoJ and the ECB announcements, respectively.
Bakogeorgos M, Mountzios G, Bournakis E, Economopoulou P, Kotsantis G, Fytrakis N, Kouvatseas G, Dimopoulos M-A, Kentepozidis N. Do elderly patients with non-small cell lung cancer get the best out of recent advances in first-line treatment? A comparative study in two tertiary cancer centers in Greece. Journal of Geriatric Oncology [Internet]. 2015;6(2):111 - 118. WebsiteAbstract
Background: Elderly patients with advanced non-small cell lung cancer (NSCLC) are thought to receive suboptimal treatment mainly due to concerns for poor compliance and/or excessive toxicity. Patients and Methods: Using the age of 70. years as the pre-defined cut-off, we compared elderly patients with advanced NSCLC suitable for first line chemotherapy with their younger counterparts in terms of: i) diagnosis and disease characteristics ii) adherence to treatment schedule, including dose intensity (DI), and relative dose intensity (RDI), iii) toxicity, tolerance, and efficacy outcomes. Results: Among 292 eligible patients, data were available for 245, of whom 107 (43.7%) belonged to the elderly group. This group was more likely to present with co-morbidities, non-smoking current status and diagnosis based on cytology alone. As compared to the non-elderly, elderly patients were more likely to receive single-agent therapy (8.0% vs. 29.2% respectively, p<. 0.001) and less likely to receive platinum-based chemotherapy (80.3% vs. 57.9%, p<. 0.001). Elderly patients also received docetaxel (24.3% vs. 40.4%), and bevacizumab (7.5% vs. 21.3%) significantly less often and received oral vinorelbine (24.3% vs. 11.8%) more frequently. Non-elderly patients were more likely to receive any of the cytotoxic drugs with RDI. >. 0.8 (49.6% vs. 33.0%, p=. 0.012) and RDI. >. 0.9 (29.6% vs. 16%, p=. 0.015). Substantial toxicity, as well as median overall survival did not differ significantly between the two groups. Conclusions: Only one third of the elderly patients received at least 80% of the scheduled treatment intensity. Nearly half received diagnosis based on cytology alone, which may deprive them from new, histology-driven, therapeutic approaches. © 2014 Elsevier Inc.
Nastos PT, Kapsomenakis J, Dalezios NR, Kotsopoulos S, Poulos S. Drought variability over Thessaly plain, Greece. Present and future changes. 2015.
Kouroutzoglou J, Flocas HA, Hatzaki M, Keay K, Simmonds I, Mavroudis A. On the dynamics of a case study of explosive cyclogenesis in the Mediterranean. Meteorology and Atmospheric Physics [Internet]. 2015;127(1):49 - 73. Publisher's Version
Felekouras E, Petrou A, Neofytou K, Moris D, Dimitrokalis N, Bramis K, Griniatsos J, Pikoulis E, Diamantis T. Early or Delayed Intervention for Bile Duct Injuries following Laparoscopic Cholecystectomy? A Dilemma Looking for an Answer. Gastroenterol Res Pract [Internet]. 2015;(Article ID 104235). Publisher's VersionAbstract
Background. To evaluate the effect of timing of management and intervention on outcomes of bile duct injury. Materials and Methods. We retrospectively analyzed 92 patients between 1991 and 2011. Data concerned patient’s demographic characteristics, type of injury (according to Strasberg classification), time to referral, diagnostic procedures, timing of surgical management, and final outcome. The endpoint was the comparison of postoperative morbidity (stricture, recurrent cholangitis, required interventions/dilations, and redo reconstruction) and mortality between early (less than 2 weeks) and late (over 12 weeks) surgical reconstruction. Results. Three patients were treated conservatively, two patients were treated with percutaneous drainage, and 13 patients underwent PTC or ERCP. In total 74 patients were operated on in our unit. 58 of them underwent surgical reconstruction by end-to-side Roux-en-Y hepaticojejunostomy, 11 underwent primary bile duct repair, and the remaining 5 underwent more complex procedures. Of the 56 patients, 34 patients were submitted to early reconstruction, while 22 patients were submitted to late reconstruction. After a median follow-up of 93 months, there were two deaths associated with BDI after LC. Outcomes after early repairs were equal to outcomes after late repairs when performed by specialists. Conclusions. Early repair after BDI results in equal outcomes compared with late repair. BDI patients should be referred to centers of expertise and experience.
Molou E, Schulpis KH, Birbilis C, Thodi G, Georgiou V, Dotsikas Y, Loukas YL. Early screening of FTO and MC4R variants in newborns of Greek origin. Journal of Pediatric Endocrinology and Metabolism [Internet]. 2015;28(5-6):619 - 622. Website
Liapis K, Kastritis E, Bagratouni T, Vassiliou S, Papachristidis A, Charitaki E, Alevizopoulos N, Harhalakis N, Terpos E, Delimpasi S, et al. Early tumor-cell gene expression changes may predict the response to first-line bortezomib-based therapy in patients with newly diagnosed multiple myeloma. Journal of B.U.ON. [Internet]. 2015;20(5):1314 - 1321. WebsiteAbstract
Purpose: Maximizing the response rate to first-line therapy in patients with multiple myeloma (MM) is important because it leads to improved outcome. Gene-expression studies have identified prognostic gene sets in patients receiving bortezomib-based therapy. Comparison of the lists of genes derived from two gene-expression-based models (GEP70, GEP80) showed that they overlap in three genes, namely PSMD4, BIRC5, and KIAA1754. An unanswered question is whether early gene-expression changes can be used as predictors of the response to first-line bortezomib. In this study we aimed to examine the predictive value of gene expression changes for the depth of response after bortezomib-based therapy in newly diagnosed MM. Methods: We prospectively assessed the relation between early PSMD4, BIRC5, and KIAA1754 gene expression changes (before therapy and one week later) and the response rate after bortezomib-based therapy in 25 patients with newly diagnosed MM. Gene expression was studied by RT-PCR on CD138-selected plasma cells, and changes were recorded as upregulation, downregulation, or unchanged. Results: Whereas baseline prognostic factors including genetic lesions and stage were not predictive of the response rate, we found that early BIRC5 and KIAA1754 gene-expression changes were significantly associated with the depth of response to bortezomib (p=0.001 and p<0.001, respectively). PSMD4 was not predictive of the depth of response. KIAA1754 upregulation was linked to complete remission (CR) or very good partial remission (VGPR). BIRC5 upregulation was linked to stable disease (SD) or progressive disease (PD). We also observed that BIRC5 upregulation was associated with worse progression-free survival (PFS). Conclusions: Our results suggest that BIRC5 and KIAA1754 gene-expression changes may predict the response to bortezomib-based therapy. These data may have relevance for the stratification and early adaptation of first-line treatment in patients with newly diagnosed MM.
Kamberidou I. The East in the Eyes of Western Women Travellers of the 18th and 19th Centuries: Solidarity and Understanding the East. Proceedings (pp. 285-311) of the International Conference ‘The East in the Eyes of the West’, Nov. 26-28, 2013. Under the Patronage of the President of Kuwait University, published May 2015. 2015:285–311.Abstract
   "It also may be said that in our travels we saw only the bright side of Islam. Well! That is just what we desired to see; … The fact of it is, we had heard quite enough of the dark side of Islam, so we determined to pursue our studies on the side looking to the sun … Is it right, fair, or just, to visit other people in their homes, or in their countries, wherever they dwell, and come away to decry them? No! It is not right!" argues Emilie Hayacinthe Loyson, after her travels in Oriental lands in the years 1894-1896. Women travellers from Great Britain, France, Germany, Switzerland, Sweden, Austria and America explored, visited, worked and resided in regions of the East that were considered “proper and safe for dynamic men only” (Smith, 1887). The mammoth body of writings by women travellers of the 18th and 19th centuries, that claim to be eyewitness descriptions of the female microcosmos, provide a rich and detailed interpretation of the Orient, including a feminine version, a female gaze. European and American women identified with the so-called Other, expressed their solidarity and participated in Muslim women’s daily domestic life, customs, female social gatherings, religious celebrations and feasts. As a result, they accused male travellers- who had written about domestic manners in the East and the position of women in Islam of misinforming or mis or misleading their readers, stressing that their accounts were based on second or third-hand information, their unrestrained imagination and exotic fantasies.  
kuwait_university_proceedings_2015.pdf the_east_in_the_eyes_of_the_west.pdf
Matsangouras I, Kalogiros I, Nastos PT, Anagnostou MN, Pytharoulis I, Bluestein HB. ECSS 2015. 2015.
Mateos MV, Richardson PG, Dimopoulos MA, Palumbo A, Anderson KC, Shi H, Elliott J, Dow E, van de Velde H, Niculescu L, et al. Effect of cumulative bortezomib dose on survival in multiple myeloma patients receiving bortezomib-melphalan-prednisone in the phase III VISTA study. American Journal of Hematology [Internet]. 2015;90(4):314 - 319. WebsiteAbstract
This analysis, using data from the bortezomib-melphalan-prednisone (VMP) arm of the Phase III VISTA study, investigated whether increased cumulative bortezomib dose could improve overall survival (OS) in transplant-ineligible patients with previously untreated multiple myeloma. Median cumulative bortezomib dose received by the 340 patients was 39 mg/m2; this was selected as the cut-off for defining the dose groups to be compared for OS. Patient characteristics were well balanced between dose groups except for age. OS was significantly longer in the higher (≥39 mg/m2) versus lower (<39 mg/m2) cumulative bortezomib dose group (median 66.3 vs. 46.2 months; hazard ratio (HR) 0.533, P<0.0001; age-adjusted HR 0.561, P=0.0002). To overcome confounding effects of early discontinuations/deaths, which were more common in the lower cumulative dose group (27 vs. 4% of patients discontinued due to adverse events (AEs) in the lower and higher cumulative dose groups, respectively), a landmark analysis was conducted at 180 days, eliminating patients who died or discontinued before this time from the analysis. OS from this landmark remained significantly longer in the higher dose group (median 60.4 vs. 50.3 months; HR 0.709, P=0.0372). Thus, higher cumulative bortezomib dose, reflecting prolonged treatment duration and/or dose intensity, appears associated with improved OS. Approaches to achieve higher cumulative doses could include subcutaneous bortezomib administration, dose/schedule modifications, continuing therapy in responding patients, and proactive AE management. © 2015 Wiley Periodicals, Inc.
Kanapitsas, A. BAMAAP. Effect of γ-radiation on the production of aflatoxin B1 by Aspergillus parasiticus in raisins (Vitis vinifera L.). Radiation Physics and Chemistry [Internet]. 2015;106:327-332. Website
Raptopoulou, K.G. PTPINNS. The effects of food processing and canning technologies on the nutritional value of foods.; 2015 pp. 117-131. Website
Sagonas K, Pafilis P, Valakos ED. Effects of insularity on digestion: living on islands induces shifts in physiological and morphological traits in island reptiles. Naturwissenschaften. 2015;102(9-10):55.Abstract
Living on islands entails numerous challenges for animals, among which resource scarcity stands out. In order to survive, animals have to optimize energy acquisition. We examined the impact of insularity on digestion comparing a series of physiological and morphological traits of adult males between insular and mainland populations of the Balkan green lizard. Island lizards had longer gastrointestinal tracts and gut passage times and higher digestive efficiencies. The dissection of the hindgut revealed an unexpected finding, the presence of cecal valves that were more frequent in island lizards. Thanks to all above islanders retain food for longer periods and thus maximize energy income and increase the amount of the extracted nutrients. That way, they secure energy income from the limited, in time and quantity, food resources of the islands.
Karamanou M, Papaioannou TG, Tsoucalas G, Laios K, Androutsos G. Electromagnetic machines in cancer treatment: The "Priore Affair". Journal of B.U.ON. [Internet]. 2015;20(3):936 - 939. Website
Zenetos A, Arianoutsou, M., Bazos, I., Balopoulou, S., Corsini-Foka, M., Dimiza, M., Drakopoulou, P., Katsanevakis, S., Kondylatos, G., Koutsikos N, et al. ELNAIS: A collaborative network on Aquatic Alien Species in Hellas (Greece). Management of Biological Invasions [Internet]. 2015;6(2):185–196. Publisher's VersionAbstract
ELNAIS is a dynamic online information platform aiming to collect and report spatial information on Aquatic Alien Species in Greek waters. It covers freshwater, marine and estuarine waters, including not only established aliens but also casual records and cryptogenic species. The ELNAIS system includes: News, List of Greek experts, Literature of findings in Greece, List of species with information on their first introduction date and source as well as photos and distribution maps. Data providers are the scientific community (publications, grey literature, and databases) as well as citizen scientists. ELNAIS provides a useful tool towards national obligations and commitments under both the European and global frameworks in respect to Non Indigenous Species (CBD, WFD, MSFD).
Lonial S, Dimopoulos M, Palumbo A, White D, Grosicki S, Spicka I, Walter-Croneck A, Moreau P, Mateos M-V, Magen H, et al. Elotuzumab therapy for relapsed or refractory multiple myeloma. New England Journal of Medicine [Internet]. 2015;373(7):621 - 631. WebsiteAbstract
Background: Elotuzumab, an immunostimulatory monoclonal antibody targeting signaling lymphocytic activation molecule F7 (SLAMF7), showed activity in combination with lenalidomide and dexamethasone in a phase 1b-2 study in patients with relapsed or refractory multiple myeloma. Methods: In this phase 3 study, we randomly assigned patients to receive either elotuzumab plus lenalidomide and dexamethasone (elotuzumab group) or lenalidomide and dexamethasone alone (control group). Coprimary end points were progression-free survival and the overall response rate. Final results for the coprimary end points are reported on the basis of a planned interim analysis of progression-free survival. Results: Overall, 321 patients were assigned to the elotuzumab group and 325 to the control group. After a median follow-up of 24.5 months, the rate of progression-free survival at 1 year in the elotuzumab group was 68%, as compared with 57% in the control group; at 2 years, the rates were 41% and 27%, respectively. Median progression-free survival in the elotuzumab group was 19.4 months, versus 14.9 months in the control group (hazard ratio for progression or death in the elotuzumab group, 0.70; 95% confidence interval, 0.57 to 0.85; P<0.001). The overall response rate in the elotuzumab group was 79%, versus 66% in the control group (P<0.001). Common grade 3 or 4 adverse events in the two groups were lymphocytopenia, neutropenia, fatigue, and pneumonia. Infusion reactions occurred in 33 patients (10%) in the elotuzumab group and were grade 1 or 2 in 29 patients. Conclusions: Patients with relapsed or refractory multiple myeloma who received a combination of elotuzumab, lenalidomide, and dexamethasone had a significant relative reduction of 30% in the risk of disease progression or death. Copyright © 2015 Massachusetts Medical Society. All rights reserved.
Tzoupis H, Leonis G, Avramopoulos A, Reis H, Czyznikowska Z, Zerva S, Vergadou N, Peristeras LD, Papavasileiou KD, Alexis MN, et al. Elucidation of the binding mechanism of renin using a wide array of computational techniques and biological assays. Journal of Molecular Graphics and Modelling [Internet]. 2015;62:138 - 149. Website
<em>Relocating the History of Science: Essays in Honor of Kostas Gavroglu</em>
Relocating the History of Science: Essays in Honor of Kostas Gavroglu. 1st ed. (Arabatzis T, Renn J, Simões A). Dordrecht: Springer; 2015 pp. vii + 383. Publisher's Version
Βαβουρανάκης Γιώργος. Εικόνα και αρχαιολογία. Η περίπτωση της προϊστορικής αρχιτεκτονικής. Μέρος Α. Αθήνα: Κάλλιπος; 2015 pp. 260. Publisher's Version
Zagouri F, Sergentanis TN, Chrysikos D, Dimopoulos M-A, Bamias A. Epothilones in epithelial ovarian, fallopian tube, or primary peritoneal cancer: A systematic review. OncoTargets and Therapy [Internet]. 2015;8:2187 - 2198. WebsiteAbstract
Ovarian cancer is the most lethal gynecologic malignancy; consequently, there is a need for effective therapies. Epothilones are microtubule-stabilizing agents that inhibit cell growth. Currently, patupilone and its four synthetic derivatives ixabepilone, BMS-310705, sagopilone, 20-desmethyl-20-methylsulfanyl epothilone B and epothilone D, as well as its derivative KOS-1584, are under clinical evaluation. This is the first systematic review conducted in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta- Analyses) guidelines that synthesizes all available data emerging from trials and evaluates the efficacy and safety of epothilones in epithelial ovarian, primary fallopian tube, and primary peritoneal cancer. Despite the fact that epothilones have proven active in taxane-resistant settings in preclinical models, it is not yet clear from Phase II/III studies reviewed here that their clinical activity is superior to that of taxanes. Nevertheless, responses to epothilones have been observed in platinum-refractory/resistant ovarian cancer patients. Moreover, despite the shared mechanism of action of epothilones, their clinical profile seems clearly different, with diarrhea being the most common dose-limiting toxicity encountered with patupilone, whereas neutropenia and sensory neuropathy are the most common toxic effects observed with the other epothilones. In any case, randomized trials comparing epothilones with standard treatments seem warranted to define further the role of these agents, whereas biomarker analysis might further optimize patient selection. © 2015 Zagouri et al.
Terpos E, Kleber M, Engelhardt M, Zweegman S, Gay F, Kastritis E, Van De Donk NWCJ, Bruno B, Sezer O, Broij A, et al. European myeloma network guidelines for the management of multiple myeloma-related complications. Haematologica [Internet]. 2015;100(10):1254 - 1266. WebsiteAbstract
The European Myeloma Network provides recommendations for the management of the most common complications of multiple myeloma. Whole body low-dose computed tomography is more sensitive than conventional radiography in depicting osteolytic disease and thus we recommend it as the novel standard for the detection of lytic lesions in myeloma (grade 1A). Myeloma patients with adequate renal function and bone disease at diagnosis should be treated with zoledronic acid or pamidronate (grade 1A). Symptomatic patients without lytic lesions on conventional radiography can be treated with zoledronic acid (grade 1B), but its advantage is not clear for patients with no bone involvement on computed tomography or magnetic resonance imaging. In asymptomatic myeloma, bisphosphonates are not recommended (grade 1A). Zoledronic acid should be given continuously, but it is not clear if patients who achieve at least a very good partial response benefit from its continuous use (grade 1B). Treatment with erythropoietic-stimulating agents may be initiated in patients with persistent symptomatic anemia (hemoglobin <10g/dL) in whom other causes of anemia have been excluded (grade 1B). Erythropoietic agents should be stopped after 6-8 weeks if no adequate hemoglobin response is achieved. For renal impairment, bortezomib-based regimens are the current standard of care (grade 1A). For the management of treatment-induced peripheral neuropathy, drug modification is needed (grade 1C). Vaccination against influenza is recommended; vaccination against streptococcus pneumonia and hemophilus influenza is appropriate, but efficacy is not guaranteed due to suboptimal immune response (grade 1C). Prophylactic aciclovir (or valacyclovir) is recommended for patients receiving proteasome inhibitors, autologous or allogeneic transplantation (grade 1A). © 2015 Ferrata Storti Foundation.
Michopoulou E, Nikita E, Valakos ED. Evaluating the efficiency of different recording protocols for entheseal changes in regards to expressing activity patterns using archival data and cross-sectional geometric properties. Am J Phys Anthropol. 2015;158(4):557-68.Abstract
OBJECTIVES: In the past decade there have been extensive discussions on the potential utility of entheseal changes (EC) as activity markers. Nevertheless, no study to date has compared different EC recording protocols with respect to their correlation to activity patterns. MATERIALS AND METHODS: This article records changes on fibrocartilaginous entheses of the upper limbs of 90 male skeletons from the documented Athens Collection using the Hawkey and Merbs (Int J Osteoarchaeol 5 (1995) 324-338), Mariotti et al. (Collegium Antropol 28 (2004) 145-159), and Villotte et al. (Am J Phys Anthropol 142 (2010) 224-234) recording schemes in order to determine which one exhibits the highest correlation with activity. Activity is assessed by means of the recorded profession of each individual, as well as employing cross-sectional geometric properties. Generalized Linear Models are used to explore the impact of age, body mass, and activity on EC expression. RESULTS: Our results agree with previous studies that age is the primary factor determining EC, whereas body mass is the second most influential factor. In contrast, activity in the form of profession or cross-sectional geometry rarely showed a significant correlation to EC expression and no clear pattern could be discerned irrespective of the recording technique. However, bilateral differences in the impact of age and body mass in EC expression were traced and may relate to activity patterns. CONCLUSIONS: The differences found in the bilateral impact of age and body mass highlight the fact that the activity patterns of the individuals under examination must play an underlying role to EC expression, though current recording schemes for EC do not capture this, rendering further work in the direction of developing more elaborate recording standards imperative.
Kountouris P, Drikos S, Aggelonidis I, Laios A, Kyprianou M. Evidence for differences in men’s and women’s volleyball games based on skills effectiveness in four consecutive Olympic tournaments. Comprehensive Psychology. 2015;4:Article–9. final_article.pdf
Diriken J, Patronis N, Andreyev A, Antalic S, Bildstein V, Blazhev A, Darby IG, De Witte H, Eberth J, Elseviers J, et al. Experimental study of the $^{66}\mathrm{Ni}(d,p) ^{67}\mathrm{Ni}$ one-neutron transfer reaction. Phys. Rev. C. 2015;91:054321.
Vrontaki E, Melagraki G, Mavromoustakos T, Afantitis A. Exploiting ChEMBL database to identify indole analogs as HCV replication inhibitors. Methods [Internet]. 2015;71(C):4 - 13. Website
Giannos A, Filipits M, Zagouri F, Brandstetter A, Tsigginou A, Sotiropoulou M, Papaspyrou I, Sergentanis TN, Psaltopoulou T, Rodolakis A, et al. Expression of ARs in triple negative breast cancer tumors: A potential prognostic factor?. OncoTargets and Therapy [Internet]. 2015;8:1843 - 1847. WebsiteAbstract
Background/aim: In light of the controversial published literature, this study aims to examine the potential prognostic role of AR immunohistochemical expression in triple negative breast cancer (TNBC). Patients and methods: Ninety patients with TNBC were included in this study; the associations between AR expression (Allred score), clinicopathological variables (stage, grade, histological subtype, tumor size, nodal status, age at diagnosis, Ki67 expression, and p53 expression), and overall survival were evaluated. Results: AR expression was not associated with stage, grade, histological subtype, tumor size, nodal status, age at diagnosis, Ki67 expression, and p53 expression. AR immunopositivity was not associated with overall survival either at the univariate or at the multivariate Cox regression analysis (multivariate hazard ratio =0.66, 95% confidence interval: 0.26–1.70, P=0.393). Conclusion: AR expression does not seem to play a prognostic role in TNBC. © 2015 Giannos et al.
Vavuranakis M, Vrachatis DA, Siasos G, Vaina S, Filis K, Sigala F, Kalogeras K, Kolokathis A-M, Moldovan C, Papaioannou TG, et al. First in Greece transcatheter aortic valve implantation using the CoreValve evolut-R retrievable and repositionable bioprosthesis with the inline sheath and the EnVeo loading guiding catheter: A major advantage for small- diameter access vessels. Hellenic Journal of Cardiology [Internet]. 2015;56(4):338 - 343. Website
Gardikas K. The Fragmented Environment of Interwar Halkidiki. In: Gounaris BC Gounaris, Basil C. ed. Mines, Olives and Monasteries. Aspects of Halkidiki's Environmental History. Thessaloniki: Epikentro, Pharos Books; 2015. pp. 163-183.
Zagouri F, Sergentanis TN, Chrysikos D, Dimopoulos M-A, Psaltopoulou T. Fulvestrant and male breast cancer: a pooled analysis. Breast Cancer Research and Treatment [Internet]. 2015;149(1):269 - 275. WebsiteAbstract
Male breast cancer is an uncommon malignancy; little is known regarding hormonal manipulations for tamoxifen-resistant male breast cancer patients. This is the first pooled analysis of the literature to synthesize all available data and to evaluate the efficacy and safety of fulvestrant in male breast cancer. This study was performed in accordance with the PRISMA guidelines. All studies that examined the efficacy of fulvestrant in male breast cancer, regardless of sample size, were considered eligible. The search strategy retrieved 31 articles; of these, five articles were eligible (23 patients) for this pooled analysis. The mean age of the study sample was 63.1 years. Adjuvant hormonal treatment was administered in 87.5 % of cases. Fulvestrant was given as first or second line in 40 % of patients, while as third line or beyond in 60 % of patients. 79.0 % of patients at fulvestrant administration had visceral metastases. Regarding best response, in 26.1 % PR was achieved, in 47.8 % of cases SD was recorded, whereas in 26.1 % of patients PD was noted. The median PFS was equal to 5 months. No grade 3 and 4 adverse events were recorded; of note, hot flashes were reported in 18.2 % of male breast cancer patients. Fulvestrant may potentially play a promising role in the optimal therapeutic strategy for male patients with breast cancer diagnosis. However, further clinical and pharmacokinetic investigations are more than warranted before fulvestrant use becomes a common practice in male breast cancer patients. © 2014, Springer Science+Business Media New York.
Mitsi E. George Chapman’s “ancient Greek souls”: translating ekphrasis in Hero and Leander. Word & Image. 2015;31(3):343-349.
Palumbo A, Bringhen S, Mateos M-V, Larocca A, Facon T, Kumar S, Offidani M, McCarthy P, Evangelista A, Lonial S, et al. Geriatric assessment predicts survival and toxicities in elderly myeloma patients: An International Myeloma Working Group report. Blood [Internet]. 2015;125(13):2068 - 2074. WebsiteAbstract
We conducted a pooled analysis of 869 individual newly diagnosed elderly patient data from 3 prospective trials. At diagnosis, a geriatric assessment had been performed. An additive scoring system (range 0-5), based on age, comorbidities, and cognitive and physical conditions, was developed to identify 3 groups: fit (score = 0, 39%), intermediate fitness (score = 1,31%), and frail (score ≥2, 30%). The 3-year overall survivalwas 84%in fit, 76% in intermediate-fitness (hazard ratio [HR], 1.61; P = .042), and 57% in frail (HR, 3.57; P < .001) patients. Thecumulative incidence of grade ≥3 nonhematologic adverse events at 12 months was 22.2%in fit, 26.4%in intermediate-fitness (HR, 1.23; P = .217), and 34.0%in frail (HR, 1.74; P < .001) patients. The cumulative incidence of treatment discontinuation at 12months was 16.5%in fit, 20.8%in intermediate-fitness (HR, 1.41; P = .052), and 31.2% in frail (HR, 2.21; P < .001) patients. Our frailty score predicts mortality and the risk of toxicity in elderly myeloma patients. The International Myeloma Working group proposes this score for the measurement of frailty in designing future clinical trials. These trials are registered at www.clinicaltrials.gov as #NCT01093136 (EMN01), #NCT01190787 (26866138MMY2069), and #NCT01346787 (IST-CAR-506).
Andersen JP, Bøgsted M, Dybkær K, Mellqvist U-H, Morgan GJ, Goldschmidt H, Dimopoulos MA, Einsele H, San Miguel J, Palumbo A, et al. Global myeloma research clusters, output, and citations: A bibliometric mapping and clustering analysis. PLoS ONE [Internet]. 2015;10(1). WebsiteAbstract
Background: International collaborative research is a mechanism for improving the development of dis-ease- specific therapies and for improving health at the population level. However, limited data are available to assess the trends in research output related to orphan diseases. Methods and Findings: We used bibliometric mapping and clustering methods to illustrate the level of fragmentation in myeloma research and the development of collaborative efforts. Publication data from Thomson Reuters Web of Science were retrieved for 2005-2009 and followed until 2013. We created a database of multiple myeloma publications, and we analysed impact and coauthorship density to identify scientific collaborations, developments, and international key players over time. The global annual publication volume for studies on multiple myeloma increased from 1,144 in 2005 to 1,628 in 2009, which represents a 43% increase. This increase is high compared to the 24% and 14% increases observed for lymphoma and leukaemia. The major proportion (>90% of publications) was from the US and EU over the study period. The output and impact in terms of citations, identified several successful groups with a large number of intra-cluster collaborations in the US and EU. The US-based myeloma clusters clearly stand out as the most productive and highly cited, and the European Myeloma Network members exhibited a doubling of collaborative publications from 2005 to 2009, still increasing up to 2013. Conclusion and Perspective: Multiple myeloma research output has increased substantially in the past decade. The fragmented European myeloma research activities based on national or regional groups are progressing, but they require a broad range of targeted research investments to improve multiple myeloma health care. © 2015 Andersen et al.
Nikiforidou K. Grammatical constructions and cross-text generalizations: Empathetic narration as genre. Constructions and Frames. 2015;7(2):187-217.Abstract
This paper investigates two tense-based constructions in English and Greek and one complementation construction in Greek, whose import is to effect a deictic shift and allow narration to proceed from the point of view of the narrated events and a participant therein. In addition to the individual formal and discourse-pragmatic properties of the patterns at hand, I focus on properties of the embedding context, showing that these unrelated constructions impose similar formal and interpretational requirements. This, in turn, supports the statement of generalizations at the level of genre, in this case ‘empathetic narration’ as a special kind of narration that departs from the default past narrative deictically anchored to the narrator and the conversational coordinates. While the analysis adopts a bottom-up, language-driven approach to genre, it also refutes an exhaustive equation with linguistic conventions, arguing that a Bakhtinian view of genre, which includes both linguistic and socio-cultural dimensions, is more appropriate for the data at hand.
Eberl H, Spanos VC. {GravitinoPack and decays of supersymmetric metastable particles}. 2015.
Eberl H, Spanos VC. {GravitinoPack and late decays involving gravitinos}. {18th International Conference From the Planck Scale to the Electroweak Scale (Planck 2015) Ioannina, Greece, May 25-29, 2015}. 2015;PLANCK2015:124.
Kamberidou I. 'GYMNAST’S ANTHEM' translated from Greek into English by Irene Kamberidou, May 11, 2015 for the concert ‘Music and Athletics,’ the opening ceremony of the “Genomics, Genetics and Exercise Biology” Symposium, Great Hall of the University of Athen. ΥΜΝΟΣ ΓΥΜΝΑΣΤΩΝ του Μενέλαου Παλλάντιου. Μεταφράστηκε 11/5/2015/ από την Ειρήνη Καμπερίδου για τη συναυλία ΜΟΥΣΙΚΗ ΚΑΙ ΑΘΛΗΤΙΣΜΟΣ, Αίθουσα Τελετών του Εθνικού και Καποδιστριακού Πανεπιστημίου Αθηνών) στο πλαίσιο της τελετής έναρξης του συνεδρίου “Genomics. 2015. gymnasts_anthem_in_english.pdf
Morphis G, Kyriazopoulou A, Nasopoulou C, Sioriki E, Demopoulos C, Zabetakis I.

Assessment of the in Vitro Antithrombotic Properties of Sardine (Sardina pilchardus) Fillet Lipids and Cod Liver Oil

. Fishes [Internet]. 2015;1:1-15. Publisher's VersionAbstract
The aim of the current study was to compare the biological activities of total polar lipids (TPL) and thin-layer chromatography (TLC) polar lipid fractions of sardine fillet and cod liver oil against atherogenesis. TPL and TLC polar lipid fractions obtained from these two sources were assessed for their ability to inhibit the platelet-activating-factor (PAF)-induced platelet aggregation (PAF-antagonists) or to induce platelet aggregation (PAF-agonists), since PAF plays a crucial role in the initiation and development of atherosclerosis. This study focused on the polar lipids since previous studies have underlined that the antithrombotic properties of foodstuffs are mainly attributed to polar lipid micro-constituents. TPL of sardine fillet induced platelet aggregation, while TPL of cod liver had a bimodal effect on platelets. TLC polar lipid fractions of both samples exhibited in vitro aggregatory and inhibitory activity towards platelets. However, TLC sardine polar lipid fractions showed stronger in vitro antithrombotic activities than the cod liver oil ones. These data constitute evidence of the putative contribution of fish polar lipids against cardiovascular diseases, underling firstly the beneficial effect of fish and fish lipids as functional foodstuffs against atherogenesis and secondly the more important role of sardine polar lipids as opposed to cod liver oil.
fishes.pdf
Balios D, Eriotis N, Fragoudaki A, Giokas D.

Economic efficiency of Greek retail SMEs in a period of high fluctuations in economic activity: a DEA approach
. Applied Economics [Internet]. 2015;47(33):3577-3593. Publisher's VersionAbstract
This study aims to analyse the economic efficiency of Greek small and medium retail enterprises before and after the crisis that started in 2008. Based on the Accounting Equation, we use Data Envelopment Analysis (DEA) to estimate variable returns of scale efficiency scores and to conclude on specific characteristics that efficient companies have, for example, on capital structure. Our results from the DEA application show a high degree of inefficiency. We found that SMEs on the islands are more efficient than those on the mainland and that SMEs in the cities are the least efficient. Size seems to be important, more so on the islands and on the mainland than in the cities. We conclude that companies should act more conservatively in terms of operating cost when the first signs of a recession appear. In addition, during a recession period, companies that have evidences that their operations will continue positively should strengthen their operations by raising more own capital. Finally, our study clarifies four issues: the efficiency of retail companies in a period of growth and a period of recession, focusing on SMEs that operate in different regions, connecting Accounting Equation and DEA and adding acid ratio as an output in our model.
Song KW, Dimopoulos MA, Weisel KC, Moreau P, Palumbo A, Belch A, Schey S, Sonneveld P, Sternas L, Yu X, et al. Health-RELATED quality of life from the MM-003 trial of pomalidomide plus LOW-Dose dexamethasone VERSUS HIGH-DOSE dexamethasone in relapsed and/or refractory multiple myeloma. Haematologica [Internet]. 2015;100(2):63 - 67. Website
Kanellakopoulos A, Angelinos N, Madesis I, Zouros TJM, Fernández-Martín M, Martínez G, Mertzimekis TJ. Hemispherical Deflector Analyzer input lens optimization using SIMION. [Internet]. 2015. Website
Papaioannou, C.D. SSPKLVJIF. Impact of different preservation treatments on lipids of the smooth clam Callista chione. International Journal of Food Science and Technology [Internet]. 2015. Website
Dimopoulos MA, Petrucci MT, Foà R, Catalano J, Kropff M, Terpos E, Zhang J, Grote L, Jacques C, Palumbo A. Impact of maintenance therapy on subsequent treatment in patients with newly diagnosed multiple myeloma: Use of “progression-free survival 2” as a clinical trial end-point. Haematologica [Internet]. 2015;100(8):e328 - e330. Website
San Miguel JF, Weisel KC, Song KW, Delforge M, Karlin L, Goldschmidt H, Moreau P, Banos A, Oriol A, Garderet L, et al. Impact of prior treatment and depth of response on survival in MM-003, a randomized phase 3 study comparing pomalidomide plus low-dose dexamethasone versus high-dose dexamethasone in relapsed/refractory multiple myeloma. Haematologica [Internet]. 2015;100(10):1334 - 1339. WebsiteAbstract
Pomalidomide is a distinct oral IMiD® immunomodulatory agent with direct antimyeloma, stromal-support inhibitory, and immunomodulatory effects. The pivotal, multicenter, open-label, randomized phase 3 trial MM-003 compared pomalidomide + low-dose dexamethasone vs high-dose dexamethasone in 455 patients with refractory or relapsed and refractory multiple myeloma after failure of bortezomib and lenalidomide treatment. Initial results demonstrated significantly longer progression-free survival and overall survival with an acceptable tolerability profile for pomalidomide + low-dose dexamethasone vs high-dose dexamethasone. This secondary analysis describes patient outcomes by treatment history and depth of response. Pomalidomide + low-dose dexamethasone significantly prolonged progression-free survival and favored overall survival vs high-dose dexamethasone for all subgroups analyzed, regardless of prior treatments or refractory status. Both univariate and multivariate analyses showed that no variable relating to either the number (≤ or > 3) or type of prior treatment was a significant predictor of progression-free survival or overall survival. No cross-resistance with prior lenalidomide or thalidomide treatment was observed. Patients achieving a minimal response or better to pomalidomide + low-dose dexamethasone treatment experienced a survival benefit, which was even higher in those achieving at least a partial response (17.2 and 19.9 months, respectively, as compared with 7.5 months for patients with less than minimal response). These data suggest that pomalidomide + low-dose dexamethasone should be considered a standard of care in patients with refractory or relapsed and refractory multiple myeloma regardless of prior treatment. ClinicalTrials.gov: NCT01311687; EudraCT: 2010-019820-30. © 2015 Ferrata Storti Foundation.
Papaioannou TG, Vardoulis O, Protogerou A, Konstantonis G, Sfikakis PP, Stefanadis C, Stergiopulos N. In vivo evaluation of a novel 'diastole-patching' algorithm for the estimation of pulse transit time: Advancing the precision in pulse wave velocity measurement. Physiological Measurement [Internet]. 2015;36(1):149 - 161. Website
Maniadakis D, Varoutas D. Incorporating Gabriel graph model for FTTx dimensioning. Photonic Network Communications. 2015;29:214–226.
Lambrinoudaki I, Armeni E, Rizos D, Georgiopoulos G, Athanasouli F, Triantafyllou N, Panoulis K, Augoulea A, Creatsa M, Alexandrou A, et al. Indices of adiposity and thyroid hormones in euthyroid postmenopausal women. European Journal of Endocrinology. 2015;173(2):237 - 245.Abstract
© 2015 European Society of Endocrinology. Objective: We aimed to evaluate the association between thyroid hormones and indices of obesity in a sample of euthyroid postmenopausal women. Design: Cross-sectional study. Methods: Serum levels of TSH, free triiodothyronine (FT3), and free thyroxine (FT4) as well as BMI and waist:hip ratio (WHR) were evaluated in 194 healthy euthyroid postmenopausal women. Ultrasonography was used to assess abdominal fat layers (subcutaneous fat (SF), preperitoneal fat (PF), and SF:PF ratio). Indices of adiposity were defined as high vs low depending on the median value of the assessed parameters. Results: After multivariate adjustment for traditional risk factors, lower FT4 levels and a higher FT3:FT4 ratio predicted higher SF mass (FT4, Exp(β)=0.035, P=0.020 and FT3:FT4, Exp(β)=2.374, P=0.018), whereas higher FT3 predicted higher PF mass (Exp(β)=2.815, P=0.032). Women with FT3:FT4 above the highest quartile had a significantly higher SF mass as compared to women in the lowest quartile (1.81±0.62 cm vs 1.54∓0.46 cm, P=0.027). BMI had a positive independent association with TSH (Exp(β)=1.829, P=0.018). Finally, FT3 was significantly associated with SF mass among women with higher BMI (FT3, β=0.259, P=0.040) and women with higher WHR (β=0.309, P=0.020) but not among women with lower BMI or WHR values. Conclusion: Thyroid hormone levels, and in particular FT3, were independently associated with SF and PF in euthyroid postmenopausal women, and this association was mainly evident in women with higher BMIs. On the other hand, among traditional indices of adiposity, only TSH was positively associated with BMI. Larger prospective studies are needed to evaluate the significance of the present findings.
Christopoulou ME, Mertzimekis TJ, Nomikou P, Papanikolaou D, Carey S, Mandalakis M. Influence of hydrothermal venting on water column properties in the crater of the Kolumbo submarine volcano, Santorini volcanic field (Greece). Geo-Marine Letters. 2015;36:1–10.Abstract
The Kolumbo submarine volcano, located 7 km northeast of the island of Santorini, is part of Santorini’s volcanic complex in the south Aegean Sea, Greece. Kolumbo’s last eruption was in 1650 AD. However, a unique and active hydrothermal vent field has been revealed in the northern part of its crater floor during an oceanographic survey by remotely operated vehicles (ROVs) in 2006. In the present study, conductivity-temperature-depth (CTD) data collected by ROV Hercules during three oceanographic surveys onboard E/V Nautilus in 2010 and 2011 have served to investigate the distribution of physicochemical properties in the water column, as well as their behavior directly over the hydrothermal field. Additional CTD measurements were carried out in volcanic cone 3 (VC3) along the same volcanic chain but located 3 km northeast of Kolumbo where no hydrothermal activity has been detected to date. CTD profiles exhibit pronounced anomalies directly above the active vents on Kolumbo’s crater floor. In contrast, VC3 data revealed no such anomalies, essentially resembling open-sea (background) conditions. Steep increases of temperature (e.g., from 16 to 19 °C) and conductivity near the maximum depth (504 m) inside Kolumbo’s cone show marked spatiotemporal correlation. Vertical distributions of CTD signatures suggest a strong connection to Kolumbo’s morphology, with four distinct zones identified (open sea, turbid flow, invariable state, hydrothermal vent field). Additionally, overlaying the near-seafloor temperature measurements on an X–Y coordinate grid generates a detailed 2D distribution of the hydrothermal vent field and clarifies the influence of fluid discharges in its formation.
Bone RN, Gai Y, Magrioti V, Kokotou MG, Ali T, Lei X, Tse HM, Kokotos G, Ramanadham S. Inhibition of Ca2+-independent phospholipase A2β (iPLA2β) ameliorates islet infiltration and incidence of diabetes in NOD mice. Diabetes. 2015;64:541-554.Abstract
Autoimmune β-cell death leads to type 1 diabetes and with findings that Ca2+-independent phospholipase A2β (iPLA2β) activation contributes to β-cell death, we assessed the effects of iPLA2β inhibition on diabetes development. Administration of FKGK18, a reversible iPLA2β inhibitor, to non-obese diabetic (NOD) mice significantly reduced diabetes incidence in association with (a) reduced insulitis, reflected by reductions in CD4+ T-cells and B-cells, (b) improved glucose homeostasis, (c) higher circulating insulin, and (d) β-cell preservation. Further, FKGK18 inhibited production of TNFα from CD4+ T-cells and antibodies from B-cells, suggesting modulation of immune cell responses by iPLA2β-derived products. Consistent with this, (a) adoptive transfer of diabetes by CD4+ T-cells to immunodeficient and diabetes-resistant NOD.scid mice was mitigated by FKGK18 pretreatment and (b) TNFα production from CD4+ T-cells was reduced by inhibitors of cyclooxygenase and 12-lipooxygenase, which metabolize arachidonic acid to generate bioactive inflammatory eicosanoids. However, adoptive transfer of diabetes was not prevented when mice were administered FKGK18-pretreated T-cells or FKGK18 administration is initiated with T-cell transfer. Our observations suggest that iPLA2β-derived lipid signals modulate immune cell responses, raising the possibility that early inhibition of iPLA2β may be beneficial in ameliorating autoimmune destruction of β-cells and mitigating type 1 diabetes development.
Kamberidou I. “Inspired Leaders–Empowering Leadership Skills: Women, Entrepreneurship and Sports”, pp. 28-30. Tips4skills conference, High Heels consortium, 19/2/2015, Athens, Greece [original in Greek]. In: Tips4skills conference, with support of the European Commission and the Lifelong Learning Programme of the European Union. High Heels consortium, EU project: http://www.highheelsproject.eu/; 2015. pp. 28–30.Abstract
Kamberidou, I. (2015). “Inspired Leaders–Empowering Leadership Skills: Women, Entrepreneurship and Sports”, pp. 28-30. Tips4skills conference, High Heels consortium, 19/2/2015, Athens, Greece [original in Greek]. In Tips4skills conference book, with support of the European Commission and the Lifelong Learning Programme of the European Union (pp. 28–30). High Heels consortium, EU project: http://www.highheelsproject.eu [Α.2.  in Apella]
tips4skills._empneysmeni_igesia.pdf high_heels_roundtable_outcomes._tips_4_skills_2015.pdf
Kamperakis N, Nastos PT, Matsangouras IT, Pytharoulis I. Instability indices and unstable atmospheric conditions over Greece. EGU General Assembly Conference Abstracts. 2015.
Aissopou EK, Bournia V-K, Protogerou AD, Panopoulos S, Papaioannou TG, Vlachoyiannopoulos PG, Matucci-Cerinic M, Sfikakis PP. Intact calibers of retinal vessels in patients with systemic sclerosis. Journal of Rheumatology [Internet]. 2015;42(4):608 - 613. Website
Integrated History and Philosophy of Science in Practice. Special Issue of<em>Studies in History and Philosophy of Science.</em>
Integrated History and Philosophy of Science in Practice. Special Issue ofStudies in History and Philosophy of Science. Arabatzis T, Howard D. [Internet]. 2015;50:1-90. Publisher's Version
Kamberidou I. Interacting, sharing and bonding: 'notes of personal experience' by 19th century women travellers. Gender, Place & Culture: A Journal of Feminist Geography [Internet]. 2015:DOI–10. Publisher's VersionAbstract
 Full text:  http://www.tandfonline.com/eprint/QfxxQ5f9E7wVHtXDu7kB/full To cite this article: Irene Kamberidou (2015): Interacting, sharing and bonding: ‘notes of personal experience’ by nineteenth-century women travellers, Gender, Place & Culture: A Journal of Feminist Geography, DOI: 10.1080/0966369X.2015.1013451  To link to this article: http://dx.doi.org/10.1080/0966369X.2015.1013451
Arabatzis T, Howard D. Introduction: Integrated history and philosophy of science in practice. Studies in History and Philosophy of Science [Internet]. 2015;50:1-3. Publisher's Version
Kellici TF, Ntountaniotis D, Leonis G, Chatziathanasiadou M, Chatzikonstantinou AV, Becker-Baldus J, Glaubitz C, Tzakos AG, Viras K, Chatzigeorgiou P, et al. Investigation of the interactions of silibinin with 2-hydroxypropyl-β-cyclodextrin through biophysical techniques and computational methods. Molecular Pharmaceutics [Internet]. 2015;12(3):954 - 965. Website
Papadakis M, Lianou A, Nikolaou VS. Isolated Fracture of the Trapezoid. A Rare Injury. J Hand Microsurg. 2015;7(1):104-5.
Karakassi K, Kotelides G, Maier A, Papadopoulou V. Kafka in Griechenland: Haring E. DER KAFKA-ATLAS Ein Online-Projekt zur weltweiten Rezeption Franz Kafkas [Internet]. 2015. Publisher's Version
Aissopou EK, Papathanassiou M, Nasothimiou EG, Konstantonis GD, Tentolouris N, Theodossiadis PG, Papaioannou TG, Sfikakis PP, Protogerou AD. The Keith-Wagener-Barker and Mitchell-Wong grading systems for hypertensive retinopathy: Associationwith target organ damage in individuals below 55 years. Journal of Hypertension [Internet]. 2015;33(11):2303 - 2309. Website
Kopanias K. The King's Household, Royal Gifts and the International Trade in the Amarna Age. In: Lévy E Kingship in Ancient Greece: from Agamemnon to Cleopatra. International Conference in honor of Pierre Carlier. Athens, 6 – 8 February 2014. KTEMA, Civilisations de l’Orient, de la Grèce et de Rome antiques 40. Strasbourg: Université Marc Bloch de Strasbourg; 2015. pp. 199-206.
Bogdanis GC a, Kalapotharakos VI b. Knee Extension Strength and Hamstrings-to-Quadriceps Imbalances in Elite Soccer Players. International Journal of Sports Medicine [Internet]. 2015;37:119-124. WebsiteAbstract
{This study examined the relationship between hamstrings-to-quadriceps strength ratio (H:Q) and relative strength of the knee extensors in elite soccer players. Peak torque was measured during isokinetic knee extension/flexion at angular velocities of 60°·s-1, 180°·s-1 and 300°·s-1. 18 professional players were divided into 2 groups, depending on their H:Q at 60°·s-1. Players in the lower H:Q group (n=7) had significantly smaller H:Q ratios compared with the higher H:Q group (n=11) at all angular velocities (60°·s-1: 49.2%; 95% CI: 61.3-57.8% vs. 59.5%; 95% CI: 52.2-46.2%
Bogdanis, G.C.a KVI b. Knee Extension Strength and Hamstrings-to-Quadriceps Imbalances in Elite Soccer Players. International Journal of Sports Medicine [Internet]. 2015;37:119-124. WebsiteAbstract
{This study examined the relationship between hamstrings-to-quadriceps strength ratio (H:Q) and relative strength of the knee extensors in elite soccer players. Peak torque was measured during isokinetic knee extension/flexion at angular velocities of 60°·s-1, 180°·s-1 and 300°·s-1. 18 professional players were divided into 2 groups, depending on their H:Q at 60°·s-1. Players in the lower H:Q group (n=7) had significantly smaller H:Q ratios compared with the higher H:Q group (n=11) at all angular velocities (60°·s-1: 49.2%; 95% CI: 61.3-57.8% vs. 59.5%; 95% CI: 52.2-46.2%
Kritikou V. La proyección de los personajes infantiles en "Retirada" de Carmen Martín Gaite y "Los metales" de Onelio Jorge Cardoso. In: Estudios y Homenajes Hispanoamericanos III. Vol. 3. 1st ed. Madrid: Ediciones del Orto; 2015. pp. 131-135. Publisher's Version kritikou.personajes_infantiles.martin_gaite.jorge_cardoso.pdf
Katodritou E, Terpos E, Kastritis E, Delimpasis S, Symeonidis AS, Repousis P, Kyrtsonis M-C, Vadikolia C, Michalis E, Polychronidou G, et al. Lack of survival improvement with novel anti-myeloma agents for patients with multiple myeloma and central nervous system involvement: the Greek Myeloma Study Group experience. Annals of Hematology [Internet]. 2015;94(12):2033 - 2042. WebsiteAbstract
Involvement of the central nervous system (CNS) is a rare complication of multiple myeloma (MM). Herein, we have described the incidence, characteristics, prognostic factors for post CNS-MM survival, and outcome of CNS-MM and explored the efficacy of novel agents (NA) (thalidomide, bortezomib, lenalidomide) in this setting. Between 2000 and 2013, 31 (0.9 %) out of 3408 newly diagnosed symptomatic MM patients, consecutively diagnosed and treated during the same period in 12 Greek centers, developed CNS-MM (M/F 15/16, median age 59 years, range 20–96 years; newly diagnosed/relapsed-refractory 2/29; median time to CNS-MM diagnosis 29 months). Clinical and laboratory characteristics were retrospectively recorded. Twenty-six percent of patients had circulating plasma cells (PCs) or plasma cell leukemia (PCL) at CNS-MM and 39 % had skull-derived plasmacytomas, suggesting hematological and contiguous spread. Treatment for CNS-MM was offered in 29/31 patients and 11/29 responded (NA 18/29, additional radiotherapy 9/28, intrathecal chemotherapy 13/29). The median post CNS-MM survival was 3 months (95 % CI 1.9–4.1) and did not differ between patients treated with NA and/or radiotherapy vs. others. In the multivariate analysis, prior treatment of MM with NA, extramedullary disease (EMD) during MM course (i.e., plasmacytomas, circulating PCs, or documented PCL) and abnormally high LDH at MM diagnosis were independent prognostic factors, whereas treatment of CNS-MM with NA did not predict for post CNS-MM survival. Despite the relatively limited number of patients due to the rarity of CNS-MM, our results suggest that NA do not seem to improve post CNS-MM survival. Patients with EMD display shortened post CNS-MM survival and should be followed thoroughly. © 2015, Springer-Verlag Berlin Heidelberg.
Christodoulakis NS, Mamoucha S, Termentzi A, Fokialakis N. Leaf structure and histochemistry of the hardy evergreen Euphorbia characias L. (Mediterranean spurge). Flora: Morphology, Distribution, Functional Ecology of Plants [Internet]. 2015;210:13 - 18. WebsiteAbstract
The dorsiventral, hypostomatic leaf of Euphorbia characias is investigated to disclose its structural features and the chemical nature of the secondary metabolites produced. Light and scanning electron microscopy along with histochemical tests were employed to investigate the leaf of this well known perennial dwarf Mediterranean shrub. The compact leaf is characterized by numerous, rather uniform, curly, unicellular hairs on both surfaces, vaulty protrusions of the outer periclinal walls of the epidermal cells, prominent on the lower epidermis in particular, and a network of latex producing ducts (laticifers) extending in two layers within the mesophyll. Histochemical reactions proved positive only for alkaloids within the laticifers and phenolic compounds, especially for the condensed tannins accumulated within the vacuole of the epidermal cells. GC-MS and GC-FID analyses of the latex revealed the presence of several secondary metabolites, mainly belonging to the class of triterpenes. Lanosterol, butyrospermol, cycloartenol and lupeol were the major constituents in the extract examined. © 2014 Elsevier GmbH.
Pappas P, Paradisis G, Vagenas G. Leg and vertical stiffness (a)symmetry between dominant and non-dominant legs in young male runners. Human Movement Science [Internet]. 2015;40:273-274. Publisher's VersionAbstract
Biomechanical findings show that running is asymmetric in many kinetic properties. Running stiffness is a vital kinetic property of yet unknown pattern of lateralization. The aim of this study was to examine the degree and variability of lower limb dominance specific asymmetry of running in terms of leg stiffness, vertical stiffness, contact time, flight time, maximal ground reaction forceduring contact, vertical displacement of the center of mass, and change in leg length. Leg and vertical stiffness was estimated by the sine-wave method in 22 young males during treadmill runningat 4.44m/s. Lower limb dominance was determined by the triple jump test. Asymmetry was expressed as dominant – non-dominant, and indexed by the absolute asymmetry index. Significant asymmetry was found only in flight time (3.98%) and in maximal ground reaction force (1.75%). The absolute asymmetry index ranged from 1.8% to 6.4%, showed high variation between subjects (0–31.6%), and differentiated among the 7 analyzed variables. Leg and vertical stiffness in treadmill running of moderate pace (4.44 m/s) should be considered symmetric.
pappas_paradisis_vagenas_2015_hms.pdf
Mitsi E. “LET US PITY THE WHITE MAN, NO MOTHER HAS HE”: KINDNESS AND CRUELTY IN MUNGO PARK’S AFRICAN TRAVELS. In: People and Cultures in Contact. University of Pristina-Kosovska Mitrovica; 2015.
Sinanoglou, V.J. ZHPĆPGSPGC. Lipid and fatty acid profile of the edible fungus Laetiporus sulphurous. Antifungal and antibacterial properties. Journal of Food Science and Technology [Internet]. 2015;52:3264-3272. Website
Kritikos N, Tsantili-Kakoulidou A, Loukas YL, Dotsikas Y. Liquid chromatography coupled to quadrupole-time of flight tandem mass spectrometry based quantitative structure-retention relationships of amino acid analogues derivatized via n-propyl chloroformate mediated reaction. Journal of Chromatography A [Internet]. 2015;1403:70-80. Publisher's Version
Karakassi K. Literatur und Geschichte: Der Fall Kafka. In: Blažević Z History as a Foreign Country/Geschichte als ein fremdes Land.Historical Imagery in the South-Eastern Europe/Historische Bilder in Süd-Ost Europa. Bonn: Bouvier Verlag; 2015. pp. 247 - 262.
Daglis IA, Jacobi C, Pinnock M. Living with a star. A voyage through scales [Internet]. 2015:26-31. Publisher's Version
Kastritis E, Roussou M, Gavriatopoulou M, Migkou M, Kalapanida D, Pamboucas C, Kaldara E, Ntalianis A, Psimenou E, Toumanidis ST, et al. Long-term outcomes of primary systemic light chain (AL) amyloidosis in patients treated upfront with bortezomib or lenalidomide and the importance of risk adapted strategies. American Journal of Hematology [Internet]. 2015;90(4):E60 - E65. WebsiteAbstract
Bortezomib and lenalidomide are increasingly used in patients with AL amyloidosis, but long term data on their use as primary therapy in AL amyloidosis are lacking while early mortality remains significant. Thus, we analyzed the long term outcomes of 85 consecutive unselected patients, which received primary therapy with bortezomib or lenalidomide and we prospectively evaluated a risk adapted strategy based on bortezomib/dexamethasone to reduce early mortality. Twenty-six patients received full-dose bortezomib/dexamethasone, 36 patients lenalidomide with oral cyclophosphamide and low-dose dexamethasone and 23 patients received bortezomib/dexamethasone at a dose and schedule adjusted to the risk of early death. On intent to treat, 67% of patients achieved a hematologic response (24% hemCRs) and 34% an organ response; both were more frequent with bortezomib. An early death occurred in 20%: in 36% of those treated with full-dose bortezomib/dexamethasone, in 22% of lenalidomide-treated patients but only in 4.5% of patients treated with risk-adapted bortezomib/dexamethasone. Activity of full vs. adjusted dose bortezomib/dexamethasone was similar; twice weekly vs. weekly administration of bortezomib also had similar activity. After a median follow up of 57 months, median survival is 47 months and is similar for patients treated with bortezomib vs. lenalidomide-based regimens. However, risk adjusted-bortezomib/dexamethasone was associated with improved 1-year survival vs. full-dose bortezomib/dexamethasone or lenalidomide-based therapy (81% vs. 56% vs. 53%, respectively). In conclusion, risk-adapted bortezomib/dexamethasone may reduce early mortality and preserve activity while long term follow up indicates that remissions obtained with lenalidomide or bortezomib may be durable, even without consolidation with alkylators. © 2015 Wiley Periodicals, Inc.
Nikolaou VS, Petit A, Khoury V, Blain-Pare E, Zukor DJ, Huk OL, Antoniou J. Magnetic resonance imaging of painful metal-on-metal total hip replacement. Eur J Orthop Surg Traumatol. 2015;25(2):313-9.Abstract
Consecutive patients that had primary metal-on-metal (MoM) or metal-on-polyethylene (MoP) hip arthroplasty were prospectively enrolled to this study. All operated hips were evaluated with MRI by one radiologist who was blinded to the radiographic findings and clinical symptoms. Three groups of patients were formed: (1) thirteen MoM THRs in 13 patients with groin pain (Group 1), (2) ten MoM THRs in 10 patients with no pain (Group 2), (3) five MoP THRs in 4 patients without pain (control group). Abnormal MRI findings were distributed in all groups in a balanced way, irrespective of the patients' symptoms, prostheses, or metal ion levels. Two patients from Group 1 and one patient of Group 3 (control group) were diagnosed with a large periprosthetic mass (pseudotumor).
Vavuranakis M, Vrachatis DA, Siasos G, Aznaouridis K, Vaina S, Moldovan C, Kalogeras K, Kariori M, Bei E, Papaioannou TG, et al. Managing complications in transcatheter aortic valve implantation. Hellenic Journal of Cardiology [Internet]. 2015;56:20 - 30. Website
Matsangouras I, Nastos P, Pytharouris I, Kamperakis N. Medicanes: A prognostic analysis of November 7, 2014, case study based on ECMWF medium range products. 2015.
Kouvelioti R, Vagenas G. Methodological and Statistical quality in research evaluating nutritional attitudes in sports. International Journal of Spots Nutrition and Exercise Metabolism [Internet]. 2015;25(6):624-635. Publisher's VersionAbstract
The assessment of dietary attitudes and behaviors provides information of interest to sports nutritionists. Although there has been little analysis of the quality of research undertaken in this field, there is evidence of a number of flaws and methodological concerns in some of the studies in the available literature. This review undertook a systematic assessment of the attributes of research assessing the nutritional knowledge and attitudes of athletes and coaches. Sixty questionnaire-based studies were identified by a search of official databases using specific key terms with subsequent analysis by certain inclusion–exclusion criteria. These studies were then analyzed using 33 research quality criteria related to the methods, questionnaires, and statistics used. We found that many studies did not provide information on critical issues such as research hypotheses (92%), the gaining of ethics approval (50%) or informed consent (35%), or acknowledgment of limitations in the implementation of studies or interpretation of data (72%). Many of the samples were non-probabilistic (85%) and rather small (42%). Many questionnaires were of unknown origin (30%), validity (72%), and reliability (70%) and resulted in low (≤ 60%) response rates (38%). Pilot testing was not undertaken in 67% of the studies. Few studies dealt with sample size (2%), power (3%), assumptions (7%), confidence intervals (3%), or effect sizes (3%). Improving some of these problems and deficits may enhance future research in this field.
kouvelioti_vagenas_2016_ijsnem.pdf
Adamopoulos PG, Kontos CK, Rapti S-M, Papadopoulos IN, Scorilas A. MiR-224 overexpression is a strong and independent prognosticator of short-term relapse and poor overall survival in colorectal adenocarcinoma. International Journal of Oncology. 2015;46:849-859.
Coll CG, Motti-Stefanidi F, Oppedal B, Pavlopoulos V, Strohmeier D, van de Vijver F, Ali AA, Asendorpf J, Dimitrova R, Ferguson GM. MISSION STATEMENT Positive Development of Immigrant Youth: Why Bother?. SRCD/EADP/EARA Experts' Meeting on Immigrant Youth Adaptation and Well-being, Hydra, Greece [Internet]. 2015. pdf
Giannopoulos L, Papaparaskevas J, Refene E, Daikos G, Stavrianeas N, Tsakris A. MLST typing of antimicrobial-resistant Propionibacterium acnes isolates from patients with moderate to severe acne vulgaris. Anaerobe. 2015;31:50-4.Abstract
Molecular typing data on antimicrobial-resistant Propionibacterium strains are limited in the literature. We examined antimicrobial resistance profiles and the underlying resistance mechanisms in Propionibacterium spp. isolates recovered from patients with moderate to severe acne vulgaris in Greece. The clonallity of the resistant Propionibacterium acnes isolates was also investigated. Propionibacterium spp. isolates were detected using Tryptone-Yeast Extract-Glucose (TYG) agar plates supplemented with 4% furazolidone. Erythromycin, clindamycin, vancomycin, penicillin, co-trimoxazole, doxycycline, minocycline and ciprofloxacin MICs were determined using the gradient strip method. Erythromycin, clindamycin and tetracycline mechanisms of resistance were determined using PCR and sequencing of the domain V of 23S rRNA and 16S rRNA, as well as the presence of the ermX gene. Typing was performed using the multi locus sequence typing (MLST) methodology. Seventy nine isolates from 76 patients were collected. Twenty-three isolates (29.1%) exhibited resistance to erythromycin and clindamycin, while two additional isolates (2.5%) were resistant only to erythromycin. Resistance to tetracycline was not detected. The underlying molecular mechanisms were point mutations A2059G and A2058G. MLST typing of the P. acnes resistant isolates revealed that lineage type IA1 (ST-1, 3 and 52) prevailed (12/18; 66.7%), whilst lineage type IA2 (ST-2 and 22) accounted for five more isolates (27.8%). Susceptible isolates were more evenly distributed between ST types. Propionibacterium spp. from moderate to severe acne vulgaris in Greece are frequently resistant to erythromycin/clindamycin but not to tetracyclines, mainly due to the point mutations A2059G and A2058G. P. acnes resistant isolates were more clonally related than susceptible ones and belonged to a limited number of MLST types.
Tsilipanos K, Neokosmidis I, Varoutas D. Modeling Complex Telecom Investments: A System of Systems Approach. Engineering Management, IEEE Transactions on. 2015;62:631–642.
Batziou E, Koutsilianou V, Stavropoulos L, Psaltis A, Mertzimekis TJ. Modeling radiative proton-capture reactions in mid–heavy nuclei. In: Hellenic Nuclear Physics Society; 2015. Website
Korres DS, Lazaretos J, Papailiou J, Kyriakopoulos E, Chytas D, Efstathopoulos NE, Nikolaou VS. Morphometric analysis of the odontoid process: using computed tomography-in the Greek population. Eur J Orthop Surg Traumatol. 2015.Abstract
AIM: A morphometric analysis of the odontoid process of the A2 vertebra, in the Greek population, was conducted using CT scan. We aimed to determine the feasibility to use one or two screws when treating fractures of this anatomic element. PATIENTS AND METHODS: One hundred and fifteen patients (57 men) of a mean age of 48 years (16-95 years) underwent a cervical spine CT scan examination. The anterior-posterior and transverse diameters of the odontoid process were measured from the base, at 1-mm interval upward on axial CT images. The length from the tip of the odontoid process to the anterior-inferior angle of the body of the axis was calculated. Data concerning the height and weight of the examined patients were collected. RESULTS: The mean transverse and anterior-posterior distances were found to be 11.46 and 10.45 mm, respectively, for the upper end of the odontoid process. At the neck level of the odontoid process, the equivalent mean values were 11.12 and 8.73 mm, respectively, while at the base, these distances were found to be 13.84 and 12.3 mm, respectively. The mean distance from the tip of the odontoid to its base was 17.25 and 17.28 mm, respectively, while the mean distance from the tip of the dens to the anterior-inferior corner of the axis' body was 39.2 mm. Men showed greater values than women. CONCLUSIONS: In this study, it was shown that in the Greek population there is enough room for one 4.5-mm or one 3.5-mm cannulated screw to be used. The application of two 3.5-mm screws is feasible in 58.6 % of the male and 26.3 % of the female population. This confirms that the knowledge of the true dimensions of the odontoid process is of paramount importance before the proper management of fractured dens using the anterior screw technique.
Kamberidou I. The Multiethnic Slavery Institution through the Eyes of Western Women and 'the real position of women in the religious system of Islam'. In: Media, Religion and Gender in Europe. 1st ed. Barcelona: Blanquerna Observatory on Media, Religion and Culture. Faculta de Comunicatio i Relacions Internacionals Blanquerna,Universitat Ramon Llull; 2015. pp. 53-79.Abstract
This chapter has shown that the multiethnic harem slavery institution was the Ottoman system’s primary socialization agent and an indispensable part of its self­-reproduction. It has contributed to the discourse on sexual slavery, primarily through the first-hand accounts of western women and harem inmates of the 19th century. It has shown that multiethnic–multiracial slavery was vital for the Ottoman economy and social system and provided a means of social integration-assimilation and social mobility: status and political power. Sexual slavery was a central part of the slave system and slaves of both genders were easily integrated into Ottoman society, eventually becoming free Muslims.       Mainly through the eyes of western women and harem inmates of the 19th century, corroborating that the harem system was based on slavery, this chapter has contributed additional evidence confirming that:  firstly, the expansionist views of Islam and the institution of slavery resulted in the multiethnic composition of the Ottoman households: harems and selemliks. Secondly, an Ottoman harem— especially that of the elite and so-called middle-class—was made up of women and children from different nations: Islamized slaves, liberated slaves and descendants of slaves, including islamized eunuchs. Thirdly, the Ottoman elite was responsible for the preservation of slavery until the early 20th century and, as a result, the prolongation of polygyny and the large-scale castration of African boys, which was another dehumanizing aspect of the Ottoman slavery institution.   Acknowledgments I would like to express my gratitude to the Greek artist Areti Kamperidis for her magnificent artwork, including her exceptional paintings, inspired by the female accounts and illustrated in this article.Keywords: human trafficking, slavery, sexual slavery, social mobility, polygyny, eunuchs, children’s harem, seraglio, marriage, divorce, veiling, gender, womenWHEN CITING: Kamberidou, I. (2015). The Multiethnic Slavery Institution through the Eyes of Western Women and 'the real position of women in the religious system of Islam'. In Miriam Diez Bosch and Jordi Sanchez Torrents (eds). Media, Religion and Gender in Europe (pp. 53-79). Barcelona: Blanquerna Observatory on Media, Religion and Culture. Faculta de Comunicatio i Relacions Internacionals Blanquerna,Universitat Ramon Llull.                     [Α.1. in Apella]    
media_religion_and_gender_in_europe_2015.pdf
Kamberidou I. The Multiethnic Slavery Institution through the Eyes of Western Women and 'the real position of women in the religious system of Islam'. In: Media, Religion and Gender in Europe. Barcelona: Blanquerna Observatory on Media, Religion and Culture. Faculta de Comunicatio i Relacions Internacionals Blanquerna,Universitat Ramon Llull. Copy at http://www.is.gd/1J2Y8D; 2015. pp. 53–79.Abstract
When citing: Kamberidou, I. (2015). The Multiethnic Slavery Institution through the Eyes of Western Women and 'the real position of women in the religious system of Islam'. In Miriam Diez Bosch and Jordi Sanchez Torrents (eds). Media, Religion and Gender in Europe (pp. 53-79). Barcelona: Blanquerna Observatory on Media, Religion and Culture. Faculta de Comunicatio i Relacions Internacionals Blanquerna,Universitat Ramon Llull.  DOI: 10.13140/RG.2.1.3034.4166 ·
media_religion_and_gender_in_europe_2015.pdf 1._book_media_religion_and_gender_in_europe_university_llull_barcelona.pdf
Kopanias K. The Mushki/Phrygian problem from the Near Eastern point of view. In: Stampolides N, Maner C, Kopanias K NOSTOI. Indigenous Culture, Migration and Integration in the Aegean Islands and Western Anatolia during the Late Bronze and Early Iron Age. Proceedings of the International Conference held in Istanbul 31/3/11-3/4/11. Istanbul: Koç University Press; 2015. pp. 211-226. Publisher's Version
Arabatzis T, Gavroglu K. Myth 18: That the Michelson-Morley Experiment Paved the Way for the Special Theory of Relativity. In: R. L. Numbers, K. Kampourakis (eds.), Newton's Apple and Other Myths about Science. Cambridge, MA: Harvard University Press; 2015. pp. 149-156, 254-255. Publisher's Version
Kotopoulou I, Mertzimekis TJ, Godelitsas A, Price R, Fike DA, Amend JP, III GWP, Druschel GK. Natural Radioactivity in Marine Sediment Cores from the Shallow-Sea Hydrothermal System off Milos Island, Greece. [Internet]. 2015. Website
Dimaki M, Chondropoulos B, Legakis A, Valakos E, Vergetopoulos M. New data on the distribution and population density of the African Chameleon, Chamaeleo africanus and the Common Chameleon, Chamaeleo chamaeleon in Greece. Hyla. 2015;1:36-43.
Chrysostomou S. The new e-books and photodentro learning object repository in Greece: Teachers’ perceptions and practices in the arts’ classroom. INTED2015 9th International Technology, Education and Development Conference. 2015.
Mendonça S, Varoutas D, Verbrugge S. New empirical approaches to telecommunications economics: Opportunities and challenges. Telecommunications Policy. 2015;39:159–161.
Godelitsas A, Tzamos E, Filippidis A, Sokaras D, Wenk T-C, Griego G, Papadopoulos A, Stoulos S, Gamaletsos P, Mertzimekis TJ, et al. New Insights into the Mineral Chemistry of Au-Bearing pyrite/As-Pyrite/arsenopyrite Concentrate from Olympias Deposit, Kassandra Mines (Chalkidiki, Greece). In: Goldschmidt Conference 2015, 16-21 August 2015, Prague, Czech Republic. Vol. 1062. ; 2015. Website
Papaioannou TG, Vavuranakis M, Stefanadis C, Tousoulis D. New technological and clinical trends in blood pressure theranostics: Is it time to consider a spatio-temporal approach?. Current Pharmaceutical Design [Internet]. 2015;21(6):697 - 699. Website
Lagaki V, Kouvaris E, Mertzimekis TJ. A new γ-spectrometry station at the University of Athens. [Internet]. 2015. Website
Markatos K, Efstathopoulos N, Kaseta KM, Nikolaou V, Tsoucalas G, Sgantzos M. Nicholas J. Giannestras (1908-1978): a distinguished orthopaedic surgeon, his work, life and times. Int Orthop. 2015;39(11):2297-302.Abstract
The purpose of our study was to summarize all the knowledge concerning the innovative pioneer in the field of orthopaedic surgery, Nicholas J. Giannestras (1908-1978). A thorough study of texts, medical books and reports, in the field of history of medicine, together with a review of the available literature in PubMed, was undertaken. Giannestras left his mark in the history of orthopaedics with his clinical work and his publications, mainly his treatise "Foot Disorders: Medical and Surgical Management" (1973), while his name lingers in Greece with the introduction of spine fusion with the use of metallic implants. He was an eminent university clinical professor of orthopaedics who had harmonically combined academic writing, teaching and clinical research in every field of orthopaedic surgery.
NOSTOI. Indigenous Culture, Migration and Integration in the Aegean Islands and Western Anatolia during the Late Bronze and Early Iron Age. Proceedings of the International Conference held in Istanbul 31/3/11-3/4/11. (Stampolides N, Maner C, Kopanias K). Istanbul: Koç University Press; 2015. Website
Kordopati GG, Tselios TV, Kellici T, Merzel F, Mavromoustakos T, Grdadolnik SG, Tsivgoulis GM. A novel synthetic luteinizing hormone-releasing hormone (LHRH) analogue coupled with modified β-cyclodextrin: Insight into its intramolecular interactions. Biochimica et Biophysica Acta - General Subjects [Internet]. 2015;1850(1):159 - 168. Website
Martzoukou O, Karachaliou M, Yalelis V, Leung J, Byrne B, Amillis S, Diallinas G. Oligomerization of the UapA purine transporter is critical for ER-exit, plasma membrane localization and turnover. J Mol Biol. 2015.Abstract
Central to the process of transmembrane cargo trafficking is the successful folding and exit from the ER through packaging in COPII vesicles. Here, we use the UapA purine transporter of Aspergillus nidulans to investigate the role of cargo oligomerization in membrane trafficking. We show that UapA oligomerizes (at least dimerizes) and that oligomerization persists upon UapA endocytosis and vacuolar sorting. Using a validated BiFC assay, we provide evidence that a UapA oligomerization is associated with ER exit and turnover, as ER-retained mutants, either due to modification of a Tyr-based N-terminal motif or partial misfolding, physically associate, but do not associate properly. Co-expression of ER-retained mutants with wild-type UapA leads to in trans plasma membrane localization of the former, confirming that oligomerization initiates in the ER. Genetic suppression of an N-terminal mutation in the Tyr motif and mutational analysis suggest that transmembrane α-helix 7 affects the oligomerization interface. Our results reveal that transporter oligomerization is essential for membrane trafficking and turnover and is a common theme in fungi and mammalian cells.
Matsangouras IT, Nastos PT. An online reposting system for tornadoes, waterspouts and funnel clouds activity over Greece: http//tornado. geol. uoa. gr. 2015.
Katavolos A. Operator algebras: an introduction. Serdica Math. J. 2015;41:49–82.
Zouros TJM, Kanellakopoulos A, Madesis I, Dimitriou A, Fernandez-Martin M, Martinez G, Mertzimekis TJ. The Optimization of a 4-Element Input Lens on a Hemispherical Deflector Analyzer Using SIMION. In: Ninth International Conference on Charged Particle Optics. Vol. 21(S4). ; 2015. pp. 148.
Krypotou E, Evangelidis T, Bobonis J, Pittis AA, Gabaldón T, Scazzocchio C, Mikros E, Diallinas G. Origin, diversification and substrate specificity in the family of NCS1/FUR transporters. Mol Microbiol. 2015.Abstract
NCS1 proteins are H(+) /Na(+) symporters specific for the uptake of purines, pyrimidines and related metabolites. In this article we study the origin, diversification and substrate specificity of fungal NCS1 transporters. We show that the two fungal NCS1 subfamilies, Fur and Fcy, and plant homologues, originate through independent horizontal transfers from prokaryotes, and that expansion by gene duplication led to the functional diversification of fungal NCS1. We characterized all Fur proteins of the model fungus Aspergillus nidulans and discovered novel functions and specificities. Homology modelling, substrate docking, molecular dynamics and systematic mutational analysis in three Fur transporters with distinct specificities identified residues critical for function and specificity, located within a major substrate binding site, in transmembrane segments TMS1, TMS3, TMS6 and TMS8. Most importantly, we predict and confirm that residues determining substrate specificity are located not only in the major substrate binding site, but also in a putative outward-facing selective gate. Our evolutionary and structure-function analysis contributes in the understanding of the molecular mechanisms underlying the functional diversification of eukaryotic NCS1 transporters, and in particular, forward the concept that selective channel-like gates might contribute to substrate specificity.
Kastritis E, Gavriatopoulou M, Dimopoulos MA, Eleutherakis-Papaiakovou E, Kanellias N, Roussou M, Pamboucas C, Toumanidis ST, Terpos E. Osteoprotegerin is a significant prognostic factor for overall survival in patients with primary systemic amyloidosis independent of the Mayo staging. Blood Cancer Journal [Internet]. 2015;5. WebsiteAbstract
Bone metabolism has not been systematically studied in primary (AL) amyloidosis. Thus we prospectively evaluated bone remodeling indices in 102 patients with newly diagnosed AL amyloidosis, 35 healthy controls, 35 newly diagnosed myeloma and 40 monoclonal gammopathy of undetermined significance patients. Bone resorption markers (C-telopeptide of type-1 collagen, N-telopeptide of type-1 collagen) and osteoclast regulators (soluble receptor activator of nuclear factor-κB ligand (sRANKL), osteoprotegerin (OPG)) were increased in AL patients compared with controls (P<0.01), but bone formation was unaffected. Myeloma patients had increased bone resorption and decreased bone formation compared with AL patients, while sRANKL/OPG ratio was markedly decreased in AL, due to elevated OPG in AL (P<0.001). OPG correlated with N-terminal pro-brain natriuretic peptide (P<0.001) and was higher in patients with cardiac involvement (P=0.028) and advanced Mayo stage (P=0.001). OPG levels above the upper value of healthy controls was associated with shorter survival (34 versus 91 months; P=0.026), while AL patients with OPG levels in the top quartile had very short survival (12 versus 58 months; P=0.024). In Mayo stage 1 disease, OPG identified patients with poor survival (12 versus >60 months; P=0.012). We conclude that increased OPG in AL is not only a compensation to osteoclast activation but may also reflect early cardiac damage and may identify patients at increased risk of death within those with earlier Mayo stage.
Kastritis E, Gavriatopoulou M, Dimopoulos MA, Eleutherakis-Papaiakovou E, Kanellias N, Roussou M, Pamboucas C, Toumanidis ST, Terpos E. Osteoprotegerin is a significant prognostic factor for overall survival in patients with primary systemic amyloidosis independent of the Mayo staging. Blood Cancer Journal [Internet]. 2015;5(6). WebsiteAbstract
Bone metabolism has not been systematically studied in primary (AL) amyloidosis. Thus we prospectively evaluated bone remodeling indices in 102 patients with newly diagnosed AL amyloidosis, 35 healthy controls, 35 newly diagnosed myeloma and 40 monoclonal gammopathy of undetermined significance patients. Bone resorption markers (C-telopeptide of type-1 collagen, N-telopeptide of type-1 collagen) and osteoclast regulators (soluble receptor activator of nuclear factor-κB ligand (sRANKL), osteoprotegerin (OPG)) were increased in AL patients compared with controls (P<0.01), but bone formation was unaffected. Myeloma patients had increased bone resorption and decreased bone formation compared with AL patients, while sRANKL/OPG ratio was markedly decreased in AL, due to elevated OPG in AL (P<0.001). OPG correlated with N-terminal pro-brain natriuretic peptide (P<0.001) and was higher in patients with cardiac involvement (P = 0.028) and advanced Mayo stage (P = 0.001). OPG levels above the upper value of healthy controls was associated with shorter survival (34 versus 91 months; P = 0.026), while AL patients with OPG levels in the top quartile had very short survival (12 versus 58 months; P = 0.024). In Mayo stage 1 disease, OPG identified patients with poor survival (12 versus 460 months; P = 0.012). We conclude that increased OPG in AL is not only a compensation to osteoclast activation but may also reflect early cardiac damage and may identify patients at increased risk of death within those with earlier Mayo stage.
Tsourou, T., DRINIA H, ANASTASAKIS G. Ostracod assemblages from Holocene middle shelf deposits of southern Evoikos Gulf (central Aegean Sea, Greece) and their palaeoenvironmental implications. Micropaleontology [Internet]. 2015;61:85-99. Publisher's Version
Morgan G, Palumbo A, Dhanasiri S, Lee D, Weisel K, Facon T, Delforge M, Oriol A, Zaki M, Yu X, et al. Overall survival of relapsed and refractory multiple myeloma patients after adjusting for crossover in the MM-003 trial for pomalidomide plus low-dose dexamethasone. British Journal of Haematology [Internet]. 2015;168(6):820 - 823. WebsiteAbstract
Summary: In the phase III MM-003 trial, pomalidomide plus low-dose dexamethasone (POM+LoDEX) improved overall survival (OS) versus high-dose dexamethasone (HiDEX) in 455 patients with relapsed and refractory multiple myeloma (RRMM) after treatment with bortezomib and lenalidomide. Here, a two-stage Weibull method was used to adjust for the crossover of patients in the HiDEX arm to pomalidomide-based therapy. The adjusted difference in median OS between patients in the POM+LoDEX and HiDEX arms was 7·0 months (12·7 vs. 5·7 months, respectively). These findings provide important evidence for understanding the clinical efficacy of pomalidomide on OS benefits seen in RRMM patients. © 2014 John Wiley & Sons Ltd.
Eleftheratos K, Kazadzis S, Zerefos CS, Tourpali K, Meleti C, Balis DS, Zyrichidou I, Lakkala K, Feister U, Koskela T, et al. Ozone and spectroradiometric UV changes in the past 20 years over high latitudes. Atmosphere-Ocean [Internet]. 2015;53:117-125. Publisher's Version a25_ao_2015.pdf
Ratopoulou M, Rousakis, G., Triantaphyllou, M., Gogou, A., Bouloubassi, I., Dimiza, M., Parinos, C., Lykousis V. A paleoceanographic approach of MIS5e interglacial deposits at the western margin of Cyclades plateau. 11th Panhellenic Symposium on Oceanography and Fisheries [Internet]. 2015;Proceeding:1001-1004. Publisher's VersionAbstract
Paleoceanographic proxies, such as marine micropaleontology, sedimentology and organic geochemistry havebeen performed in the sediment record of SK-3 gravity core (total length 217cm, water depth 249m) in order toprovide possible determination of late interglacial-Holocene the paleoenvironmental changes, at the southwestern margin of Cyclades plateau in the SW Aegean Sea. The sediment core exhibits two sapropels layer; thefirst one is associated with sapropel S1. The second sapropelic layer which we focus on represents anoxicconditions during the high sea-level warm event associated with sapropel S5 deposition.
Kouli K, Rousakis, G., Kyrikou, S., Ratopoulou, M., Triantaphyllou, M., Dimiza, M., Bouloubassi, I., Gogou, A., Kapsimalis, V., Lykousis V. Palynological investigation of the marine core SK-3 (SW Aegean Sea): implications on the vegetation of the last interglacial. 11th Panhellenic Symposium on Oceanography and Fisheries [Internet]. 2015;Proceeding:1009-1012. Publisher's VersionAbstract
Detailed pollen analyses were performed at the lower sapropelic deposits of the marine core SK-3 within theframework of a multiproxy palaeoceanographic-palaeoenvironmental study. Pollen flora is characterized byhigh arboreal pollen abundances, mainly deciduous Quercus, together with Pinus, Juniperus and otherdeciduous taxa. A transition is marked from vegetation where Mediterranean elements appear more abundanttowards mixed deciduous woodland. In the upper part of the deposits an expansion of Abies, Pinus and Fagushas been recorded. The overall vegetation pattern adds significant evidence about the terrestrialpalaeoenvironmental conditions during deposition of sapropel S5.
Richardson PG, Laubach JP, Lonial S, Moreau P, Yoon S-S, Hungria VT, Dimopoulos MA, Beksac M, Alsina M, San-Miguel JF. Panobinostat: A novel pan-deacetylase inhibitor for the treatment of relapsed or relapsed and refractory multiple myeloma. Expert Review of Anticancer Therapy [Internet]. 2015;15(7):737 - 748. WebsiteAbstract
Outcomes for patients with multiple myeloma (MM) have improved significantly over the past decade. Despite these advances, MM remains incurable and an unmet medical need remains for patients who are relapsed and/or refractory. Panobinostat is a potent, oral pan-deacetylase inhibitor that elicits anti-myeloma activity through epigenetic modulation of gene expression and disruption of protein metabolism. Preclinical data demonstrated that panobinostat has synergistic effects on myeloma cells when combined with bortezomib and dexamethasone. In a Phase III clinical trial evaluating bortezomib and dexamethasone in combination with panobinostat or placebo in patients with relapsed or relapsed and refractory MM (PANORAMA 1), panobinostat led to a significant increase in median progression-free survival. Panobinostat is currently under regulatory review with a recent accelerated approval granted for the treatment of relapsed disease, in which both bortezomib and immunomodulatory drugs have failed. Here, we summarize the preclinical, pharmacokinetic and clinical data for panobinostat in MM. © 2015 Informa UK, Ltd.
Tsapaki V, Tsalafoutas IA, Fagkrezos D, Lazaretos I, Nikolaou VS, Efstathopoulos N. PATIENT RADIATION DOSES IN VARIOUS FLUOROSCOPICALLY GUIDED ORTHOPAEDIC PROCEDURES. Radiat Prot Dosimetry. 2015.Abstract
All orthopaedic fluoroscopic procedures performed using C-arm guidance were monitored for 1 y. The type of procedure, fluoroscopy time (T), kerma-area product (KAP) values and number of radiographs (F) were recorded. The two most often performed techniques were as follows: intramedullary nailing (IMN) of intertrochanteric/peritrochanteric (IP) fractures (101 cases, 49.3 %) and antergrade IMN of femur or tibia shaft (TS) fractures (28 cases, 13.7 %). For the remaining procedures, none accounted for >5 %, categorised as 'various' (76 cases, 37 %). Large variations in T, KAP and F were observed. For IMN of IP fractures, antergrade IMN of femur and TS fractures and for various procedures, respectively, median values were T-2.1, 2.2 and 0.6 min, KAP-6.3, 6.3 and 0.6 Gy cm(-2) and F-21, 2.2 and 6.7. The patient doses during fluoroscopically guided procedures are relatively low compared with other interventional procedures.
Markatos K, Kaseta M, Nikolaou VS. Perioperative Skin Preparation and Draping in Modern Total Joint Arthroplasty: Current Evidence. Surg Infect (Larchmt). 2015;16(3):221-5.Abstract
BACKGROUND: Besides the vast success and reliability of lower extremity joint replacement, deep and periprosthetic infection remains a serious complication of such operations. Many publications addressing periprosthetic infection have remarked about this "devastating" complication, with a risk around 1% after total hip arthroplasty and between 1% and 2% after total knee arthroplasty. The purpose of this study is to assess current trends in prevention of contamination with improved up-to-date pre-operative skin preparation methods and intra-operative draping. METHODS: A literature review was conducted in MEDLINE, Web of Science, and the Cochrane database, looking for high-quality papers summarizing the most widely held and up-to-date concepts of perioperative measures for reducing infection, focusing on the best available evidence concerning skin preparation for joint arthroplasty (THR and THR) and surgical draping. RESULTS: Current evidence suggests the use of alcohol solutions for pre-operative painting with emphasis on the use of chlorhexidine gluconate solutions beginning the night before surgery. Hair removal should be performed in the operating room with electric clippers, not razor blades. In order to enhance drape adhesion to the skin, the use of iodophor-in-alcohol solutions is recommended over the traditional scrub-and-paint technique. Disposable non-woven drapes are superior to reusable woven cotton/linen drapes in resisting bacterial penetration. Finally, the use of adherent plastic adhesive incision drapes for the prophylaxis of post-operative surgical site infections is considered not necessary in orthopedic surgery. CONCLUSIONS: The importance of skin preparation and adequate and reliable draping cannot be overemphasized for infection prevention, especially in clean operations such as THR and TKR. Thorough and strict protocols are mandatory for every department, as well as education curricula for operating room personnel. Further randomized studies are mandatory to specify the effect of the above measures, their pitfalls, and their improvement, along with further crucial details such as cost-benefit analysis of different pre-operative preparations in preventing infections.
Vecchione M, Schwartz SH, Caprara GV, Schoen H, Cieciuch J, Silvester J, Bain P, Bianchi G, Kirmanoglu H, Baslevent C, et al. Personal values and political activism: A cross-national study. British Journal of Psychology. 2015;106:84–106.
Perverse fragments: citing Cavafy in crisis-stricken Athens. Journal of Greek Media & Culture [Internet]. 2015;1(2):191-205. Publisher's VersionAbstract
A publicity campaign run in Athens by the Alexander S. Onassis Public Benefit Foundation in October 2013 in order to advertise its acquisition of the Cavafy Archive, until then lying in relevant obscurity, turned into a media disaster when critics and members of the public protested against what they argued was a misquoting of the highly revered Alexandrian. In this paper, I am looking at this rather entertaining story of misunderstood intentions in order to suggest that even though Cavafy himself may be shown to have enjoyed history as fragmented experience, and despite the fact that the modern archive is one of often conflicting partialities rather than one of completeness, we, as consumers of Cavafy’s oeuvre, tend to sustain his long-established position as a paragon of Greek culture, canonised through his own nonconformity. As a typical case of ‘archive fever’, the events described here confirm the political specificity of any literary discourse, even when conducted out of context (or especially so).
Kellici TF, Liapakis G, Tzakos AG, Mavromoustakos T. Pharmaceutical compositions for antihypertensive treatments: A patent review. Expert Opinion on Therapeutic Patents [Internet]. 2015;25(11):1305 - 1317. Website
Orlowski RZ, Gercheva L, Williams C, Sutherland H, Robak T, Masszi T, Goranova-Marinova V, Dimopoulos MA, Cavenagh JD, Špička I, et al. A phase 2, randomized, double-blind, placebo-controlled study of siltuximab (anti-IL-6 mAb) and bortezomib versus bortezomib alone in patients with relapsed or refractory multiple myeloma. American Journal of Hematology [Internet]. 2015;90(1):42 - 49. WebsiteAbstract
We compared the safety and efficacy of siltuximab (S), an anti-interleukin-6 chimeric monoclonal antibody, plus bortezomib (B) with placebo (plc) + B in patients with relapsed/refractory multiple myeloma in a randomized phase 2 study. Siltuximab was given by 6 mg/kg IV every 2 weeks. On progression, B was discontinued and high-dose dexamethasone could be added to S/plc. Response and progression-free survival (PFS) were analyzed pre-dexamethasone by European Group for Blood and Marrow Transplantation (EBMT) criteria. For the 281 randomized patients, median PFS for S + B and plc + B was 8.0 and 7.6 months (HR 0.869, P = 0.345), overall response rate was 55 versus 47% (P = 0.213), complete response rate was 11 versus 7%, and median overall survival (OS) was 30.8 versus 36.8 months (HR 1.353, P = 0.103). Sustained suppression of C-reactive protein, a marker reflective of inhibition of interleukin-6 activity, was seen with S + B. Siltuximab did not affect B pharmacokinetics. Siltuximab/placebo discontinuation (75 versus 66%), grade ≥3 neutropenia (49 versus 29%), thrombocytopenia (48 versus 34%), and all-grade infections (62 versus 49%) occurred more frequently with S + B. The addition of siltuximab to bortezomib did not appear to improve PFS or OS despite a numerical increase in response rate in patients with relapsed or refractory multiple myeloma. © 2014 Wiley Periodicals, Inc.
Kouli K. Plant landscape and land use at the Neolithic lake settlement of Dispilió (Macedonia, Northern Greece). Plant Biosystems [Internet]. 2015;149(1):145-204. Publisher's VersionAbstract
The Neolithic settlement of Dispilió (lake Orestiás, northern Greece) is a unique site due to its continual inhabitation from the Middle Neolithic (5400 BC) to the Chalcolithic (3600 BC) and its exceptional location at the shore of Lake Orestiás (also known as Lake Kastoria). The plant landscape shaping of the area has been examined by correlating pollen and non-pollen palynomorphs (NPPs) from both on-site and off-site records. The examined pollen profiles bear concrete evidence of agricultural activities and land use in the area. The local pollen assemblages identified, each of them corresponding either to a different kind or intensity of exploitation of natural resources, display the diachronic evolution of the cultural landscape during more than 2000 years of human activity. The successive phases of intense human impact on vegetation patterns are in good accordance with the periods of major constructing activities described by the archaeological study of the Dispilió settlement. Finally, the differences on palynomorph accumulation pathways of the examined records made possible the distinction between local and “regional” plant landscapes and related human activities.
Richardson PG, Palumbo A, Schey SA, Dimopoulos MA, Facon T, Weisel KC, O'Gorman P, Leleu X, Lacy MQ, Streetly MJ, et al. Pomalidomide - An appraisal of its clinical development and role in the treatment of relapsed/refractory multiple myeloma. European Oncology and Haematology [Internet]. 2015;11(2):109 - 117. WebsiteAbstract
Pomalidomide is a distinct immunomodulatory agent with significant activity in relapsed/refractory multiple myeloma (RRMM). The optimal treatment schedule in patients with RRMM who have received multiple lines of treatment, including bortezomib and lenalidomide, is 4 mg/day on days 1-21 of a 28-day cycle in combination with weekly low-dose dexamethasone. Improved responses and outcomes relative to traditional therapies continue to be confirmed in recently completed and ongoing trials. Pomalidomide exhibits direct tumoricidal, immunomodulatory, anti-angiogenic and anti-inflammatory activities, which facilitate combination therapy with agents with complementary mechanisms of action, resulting in greater anti-myeloma effects than single-agent therapy or previous combination therapies. For example, in combination with proteasome inhibitors and traditional chemotherapeutic agents in doublet or triplet regimens, pomalidomide provides high rates of durable response, and represents an important new treatment option for patients with RRMM requiring effective new therapies. Additionally, pomalidomide maintains its efficacy and tolerability profile in difficult-to-treat patients, including the elderly, patients with poor cytogenetics and those with renal impairment. This review summarises the clinical development of pomalidomide and discusses this effective agent for the treatment of patients with RRMM in the context of current myeloma treatment options, as well as potential future directions to further improve patient outcomes.
Weisel K, Dimopoulos M, Song KW, Moreau P, Palumbo A, Belch A, Schey S, Sonneveld P, Sternas L, Yu X, et al. Pomalidomide and Low-Dose Dexamethasone Improves Health-Related Quality of Life and Prolongs Time to Worsening in Relapsed/Refractory Patients With Multiple Myeloma Enrolled in the MM-003 Randomized Phase III Trial. Clinical Lymphoma, Myeloma and Leukemia [Internet]. 2015;15(9):519 - 530. WebsiteAbstract
Background Health-related quality of life (HRQoL) is an important element for consideration in treatment decisions in patients with relapsed/refractory multiple myeloma (RRMM). The pivotal MM-003 (A Phase 3, Multicenter, Randomized, Open-Label Study to Compare the Efficacy and Safety of Pomalidomide in Combination With Low-Dose Dexamethasone vs. High-Dose Dexamethasone in Patients With Refractory Multiple Myeloma or Relapsed and Refractory Multiple Myeloma and Companion Study [NIMBUS]) randomized, open-label, multicenter, phase III trial demonstrated improved progression-free survival (PFS) and prolonged overall survival (OS) with pomalidomide (POM) plus low-dose dexamethasone (POM + LoDEX) versus high-dose dexamethasone (HiDEX) in patients with RRMM in whom lenalidomide (LEN) and bortezomib (BORT) had failed. MM-003 also investigated HRQoL as a predefined secondary end point. Patients and Methods Recruited patients (n = 455) were refractory to their last treatment and had failed LEN and BORT after ≥ 2 consecutive cycles of each (alone or in combination). Eight clinically relevant and validated HRQoL domains from the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30, EORTC QLQ-MY20, and EQ-5D questionnaires were selected for analysis. Time to symptom worsening based on minimally important differences (MIDs) was calculated. Results Clinically meaningful improvements in HRQoL as determined by MIDs, regression analyses, and best response analyses were observed more frequently in patients receiving POM + LoDEX than in those receiving HiDEX. POM + LoDEX significantly extended median time to clinically meaningful worsening in HRQoL versus HiDEX in 4 HRQoL domains and demonstrated a trend in an additional 3 domains. Patients in the HiDEX arm experienced earlier HRQoL deterioration compared with those in the POM + LoDEX arm in each domain analyzed. Conclusion POM + LoDEX offer good clinical outcomes that lead to improved and prolonged HRQoL compared with HiDEX in patients with RRMM and end-stage disease. © 2015 Elsevier Inc.
Nastos PT, Kapsomenakis J, Matsangouras IT, Poulos SE. Precipitation over Thessaly plain, Greece. Present and future changes. 14th International Conference on Environmental Science and Technology, Rhodes, Greece. 2015.
Karatsolis B, Triantaphyllou, M., Dimiza, M., Psarra, S., Birli, A., Mara, P., Lagaria, A., Gogou A. Preliminary results of coccolithophore evidence for the direct influence of Black Sea waters inflow into the N. Aegean Sea. 11th Panhellenic Symposium on Oceanography and Fisheries [Internet]. 2015;Proceeding:821-824 (in Greek). Publisher's VersionAbstract
A study on living coccolithophores from the euphotic zone is conducted in the northeastern Aegean Sea, anarea under the direct influence of the Black Sea waters inflowing into the Aegean. A total of 53 planktonsamples from 5 stations have been collected during four sampling periods between 2011 and 2014. Highconcentrations of Emiliania huxleyi and low concentrations of oligotrophic species, such asholococcolithophores, are indicative of a direct influence of the Black Sea waters inflow on the coccolithophoreassemblages in the northeastern Aegean Sea.
Sismani C, Christopoulou G, Alexandrou A, Evangelidou P, Donoghue J, Konstantinidou AE, Velissariou V. A prenatally ascertained de novo terminal deletion of chromosomal bands 1q43q44 associated with multiple congenital abnormalities in a female fetus. Case reports in genetics. 2015;2015.
Bleta A, Nastos P. Present and Future Human Thermal Bioclimatic Conditions and Impacts on Respiratory Admissions in Crete Island, Greece. In: EGU General Assembly Conference Abstracts. Vol. 17. ; 2015. pp. 1049.
Kostić N, Dotsikas Y, Jović N, Stevanović G, Malenović A, Medenica M. Quantitation of pregabalin in dried blood spots and dried plasma spots by validated LC-MS/MS methods. Journal of Pharmaceutical and Biomedical Analysis [Internet]. 2015;109:79 - 84. Website
Kenourgios D, Papadamou S, Dimitriou D. On quantitative easing and high frequency exchange rate dynamics. Research in International Business and Finance [Internet]. 2015;34(1):11--125. Publisher's VersionAbstract
This paper examines the effects of quantitative easing (QE) announcements by the European Central Bank, the Bank of Japan and the Bank of England on exchange rate dynamics. Using intraday data of three major exchange rates (EUR/USD, GBP/USD, JPY/USD), we apply a univariate APARCH(1,1) model and include QE dummies to empirically investigate how exchange rates are affected in mean and volatility. The empirical results indicate: (i) a direct negative impact on GBP and JPY and no effect of their volatility around the QE announcements of the corresponding central banks, (ii) a delayed devaluation of EUR and an increase of its volatility before and after the ECB’s announcements. Furthermore, the behavior of dynamic conditional correlation among currencies is investigated across the QE announcements. We find a decline in the conditional correlation between EUR and GBP around the announcements by the BoE. These findings highlight the differences on the credibility and effectiveness of the monetary easing strategies and provide important implications from the investors’ and policy makers’ perspective.
Vrontaki E, Mavromoustakos T, Melagraki G, Afantitis A. Quantitative nanostructure-activity relationship models for the risk assessment of nanomaterials. In: Quantitative Structure-Activity Relationships in Drug Design, Predictive Toxicology, and Risk Assessment. ; 2015. pp. 535 - 559. Website
Kritikos N, Loukas YL, Dotsikas Y. Quantitative structure-chemiluminescence intensity relationships of 4-substituted phenols acting as luminol signal enhancers. Chemometrics and Intelligent Laboratory Systems [Internet]. 2015;146:478 - 484. Website
Petrou A, Neofytou K, Mihas C, Bagenal J, Kontos M, Griniatsos J, Felekouras E. Radiofrequency ablation-assisted liver resection: a step toward bloodless liver resection. Hepatobiliary Pancreat Dis Int. 2015;14:69-74.Abstract
BACKGROUND: Liver resection is currently the most efficient curative approach for a wide variety of liver tumors. The application of modern techniques and new surgical devices has improved operative outcomes. Radiofrequency ablation is used more often for liver parenchymal transection. This study aimed to assess the efficacy and safety of radiofrequency ablation-assisted liver resection. METHODS: A retrospective study of 145 consecutive patients who underwent radiofrequency ablation-assisted liver resection was performed. Intraoperative blood loss, need for transfusion or intraoperative Pringle maneuver, the duration of liver parenchymal transection, perioperative complications, and postoperative morbidity and mortality were all evaluated. RESULTS: Fifty minor and ninety-five major liver resections were performed. The mean intraoperative blood loss was 251 mL, with a transfusion rate of 11.7%. The Pringle maneuver was necessary in 12 patients (8.3%). The mean duration for parenchymal transection was 51.75 minutes. There were 47 patients (32.4%) with postoperative complications. There is no mortality within 30 days after surgery. CONCLUSIONS: Radiofrequency ablation-assisted liver resection permits both major and minor liver resections with minimal blood loss and without occlusion of hepatic inflow. Furthermore it decreases the need for blood transfusion and reduces morbidity and mortality. (
Kellici TF, Tzakos AG, Mavromoustakos T. Rational drug design and synthesis of molecules targeting the angiotensin II type 1 and type 2 receptors. Molecules [Internet]. 2015;20(3):3868 - 3897. Website
Kellici T, Ntountaniotis D, Vrontaki E, Liapakis G, Moutevelis-Minakakis P, Kokotos G, Hadjikakou S, Tzakos AG, Afantitis A, Melagraki G, et al. Rational drug design paradigms: The odyssey for designing better drugs. Combinatorial Chemistry and High Throughput Screening [Internet]. 2015;18(3):238 - 256. Website
Nastos PT, Kapsomenakis J. Regional climate model simulations of extreme air temperature in Greece. Abnormal or common records in the future climate?. Atmospheric Research [Internet]. 2015;152:43 - 60. WebsiteAbstract
The aim of this study is to analyze and quantify the future projections of heat waves in Greece. For this reason, specific climatic indices were used in the analysis concerning absolute, percentile and duration indices defined by the CCl/CLIVAR/JCOMM Expert Team (ET) on Climate Change Detection and Indices (ETCCDI). The future projections (SRES A1B) of these indices such as summer days, tropical days, maximum daily maximum air temperature, warm days, tropical nights, maximum daily minimum air temperature, warm nights and warm spell duration were carried out using six regional climate models from the ENSEMBLES project, concerning the near future 2031-2050 and the far future 2071-2100 compared to the reference period 1961-1990. The ensemble means along with the inter-model-standard deviations of the examined extreme indices for the future model projections are presented and analyzed. Further, the findings of this analysis are discussed against recent recorded heat waves during 2007, in order to understand if such events are even more extreme or common in the future climate. It is very likely, that the anomalies observed in 2007, especially for extreme indices of minimum air temperature, could be more frequent considered as typical events by the end of the 21th century. © 2014 Elsevier B.V.
Κουκουνάρας- Λιάγκης Μάριος. Religion and Religious Diversity within Education in a Social Pedagogical Context in Times of Crisis: Can Religious Education Contribute to Community Cohesion?. The International Journal of Social Pedagogy. 2015;4(1):85-100. religion_and_religious_diversity_within.pdf
Κουκουνάρας- Λιάγκης Μάριος. Religious Education in Greece - Orthodox Christianity, Islam and Secularism. European Journal of Social Sciences, Education and Research. 2015;5(1):44-53. religious_education_in_greece_-_orthodox_christianity_islam_and_secularism_marios_koukounaras_liagkis_angeliki_ziaka.pdf
Dimopoulos MA, Terpos E. Reply to D.L. Cooper. Journal of Clinical Oncology [Internet]. 2015;33(26):2926 - 2927. Website
Dimopoulos MA, Swern AS, Li JS, Hussein M, Weiss L, Nagarwala Y, Baz R. Response to letter, 'immortal time bias in retrospective analysis'. Blood cancer journal [Internet]. 2015;5:e327. Website
Arabatzis T. Review of J. Navarro, A History of the Electron: J. J. and G. P. Thomson (Cambridge: Cambridge University Press, 2012). Isis [Internet]. 2015;106(1):204-205. Publisher's Version
Palumbo A, Avet-Loiseau H, Oliva S, Lokhorst HM, Goldschmidt H, Rosinol L, Richardson P, Caltagirone S, Lahuerta JJ, Facon T, et al. Revised international staging system for multiple myeloma: A report from international myeloma working group. Journal of Clinical Oncology [Internet]. 2015;33(26):2863 - 2869. WebsiteAbstract
Purpose: The clinical outcome of multiple myeloma (MM) is heterogeneous. A simple and reliable tool is needed to stratify patients with MM. We combined the International Staging System (ISS) with chromosomal abnormalities (CA) detected by interphase fluorescent in situ hybridization after CD138 plasma cell purification and serum lactate dehydrogenase (LDH) to evaluate their prognostic value in newly diagnosed MM (NDMM). Patients and Methods: Clinical and laboratory data from 4,445 patients with NDMM enrolled onto 11 international trials were pooled together. The K-adaptive partitioning algorithm was used to define the most appropriate subgroups with homogeneous survival. Results: ISS, CA, and LDH data were simultaneously available in 3,060 of 4,445 patients. We defined the following three groups: revised ISS (R-ISS) I (n = 871), including ISS stage I (serum β2-microglobulin level < 3.5 mg/L and serum albumin level ≥ 3.5 g/dL), no high-risk CA [del(17p) and/or t(4;14) and/or t(14;16)], and normal LDH level (less than the upper limit of normal range); R-ISS III (n = 295), including ISS stage III (serum β2-microglobulin level > 5.5 mg/L) and high-risk CA or high LDH level; and R-ISS II (n = 1,894), including all the other possible combinations. At a median follow-up of 46 months, the 5-year OS rate was 82% in the R-ISS I, 62% in the R-ISS II, and 40% in the R-ISS III groups; the 5-year PFS rates were 55%, 36%, and 24%, respectively. Conclusion: The R-ISS is a simple and powerful prognostic staging system, and we recommend its use in future clinical studies to stratify patients with NDMM effectively with respect to the relative risk to their survival. © 2015 American Society of Clinical Oncology. All rights reserved.
Mitsi E, Mertzimekis TJ. RICOCHET: A quick-and-dirty approach to analyze μ-XRF synchrotron data using open-source utilities. In: Hellenic Nuclear Physics Society; 2015. Website
Sergentanis TN, Zagouri F, Tsilimidos G, Tsagianni A, Tseliou M, Dimopoulos MA, Psaltopoulou T. Risk Factors for Multiple Myeloma: A Systematic Review of Meta-Analyses. Clinical Lymphoma, Myeloma and Leukemia [Internet]. 2015;15(10):563 - 577e3. WebsiteAbstract
The epidemiology of multiple myeloma (MM) is an increasingly investigated field, with many controversies. This systematic review aims to synthesize meta-analyses examining risk factors for MM so as to provide a comprehensive, parsimonious summary of the current evidence. Eligible meta-analyses were sought in PubMed adopting a predefined algorithm, without any restriction of publication language; end-of-search date was October 10, 2014. The selection of eligible studies and data extraction were performed by working in pairs, independently and blindly to each other; in case of disagreement, consensus with the whole team was reached. Among the 22 ultimately included meta-analyses, 9 examined occupational factors, 4 assessed aspects of lifestyle (smoking, alcohol, body mass index), 5 evaluated the presence of other diseases, and 4 addressed genetic factors as potential risk factors of MM. A vast compendium of significant associations arose, including farming, occupation as a firefighter, occupation as a hairdresser, exposures to chemicals or pesticides, overweight and obesity, patterns of alcohol intake, pernicious anemia, ankylosing spondylitis, gene promoter methylation, and polymorphisms. In conclusion, MM is a multifactorial disease, encompassing a wide variety of risk factors that span numerous life aspects. Further accumulation of evidence through meta-analyses is anticipated in this rapidly growing field. © 2015 Elsevier Inc.
Siasos G, Mourouzis K, Oikonomou E, Tsalamandris S, Tsigkou V, Vlasis K, Vavuranakis M, Zografos T, Dimitropoulos S, Papaioannou TG, et al. The role of endothelial dysfunction in aortic aneurysms. Current Pharmaceutical Design [Internet]. 2015;21(28):4016 - 4034. Website
Dimopoulos MA, Hillengass J, Usmani S, Zamagni E, Lentzsch S, Davies FE, Raje N, Sezer O, Zweegman S, Shah J, et al. Role of magnetic resonance imaging in the management of patients with multiple myeloma: A consensus statement. Journal of Clinical Oncology [Internet]. 2015;33(6):657 - 664. WebsiteAbstract
Purpose: The aim of International Myeloma Working Group was to develop practical recommendations for the use of magnetic resonance imaging (MRI) in multiple myeloma (MM). Methods: An interdisciplinary panel of clinical experts on MM and myeloma bone disease developed recommendations for the value of MRI based on data published through March 2014. Recommendations: MRI has high sensitivity for the early detection of marrow infiltration by myeloma cells compared with other radiographic methods. Thus, MRI detects bone involvement in patients with myeloma much earlier than the myeloma-related bone destruction, with no radiation exposure. It is the gold standard for the imaging of axial skeleton, for the evaluation of painful lesions, and for distinguishing benign versus malignant osteoporotic vertebral fractures. MRI has the ability to detect spinal cord or nerve compression and presence of soft tissue masses, and it is recommended for the workup of solitary bone plasmacytoma. Regarding smoldering or asymptomatic myeloma, all patients should undergo whole-body MRI (WB-MRI; or spine and pelvic MRI if WB-MRI is not available), and if they have > one focal lesion of a diameter > 5 mm, they should be considered to have symptomatic disease that requires therapy. In cases of equivocal small lesions, a second MRI should be performed after 3 to 6 months, and if there is progression on MRI, the patient should be treated as having symptomatic myeloma. MRI at diagnosis of symptomatic patients and after treatment (mainly after autologous stem-cell transplantation) provides prognostic information; however, to date, this does not change treatment selection. © 2015 by American Society of Clinical Oncology.
Arabatzis T, Ioannidou D. The role of models and analogies in the Bohr atom. In: F. Aaserud and H. Kragh (eds.), One Hundred Years of the Bohr Atom. Copenhagen: The Royal Danish Academy of Sciences and Letters; 2015. pp. 360-376. 2015b
Kappou D, Sifakis S, Konstantinidou A, Papantoniou N, Spandidos DA. Role of the angiopoietin/Tie system in pregnancy (Review). Experimental and therapeutic medicine. 2015;9(4):1091-1096.
Figgou L, Pavlopoulos V. Social Psychology: Research Methods. In: International Encyclopedia of the Social and Behavioral Sciences. Oxford, UK: Elsevier; 2015. pp. 544-552. pdf
Hatzaki M, Wu R. The south-eastern Europe winter precipitation variability in relation to the North Atlantic SST. Atmospheric Research [Internet]. 2015;152:61 - 68. Publisher's Version
Kouli K, Roussakis G, Kyrikou S, Ratopoulou M, Triantafyllou MV, Dimiza M, Bouloubassi I, Gogou A, Kapsimalis V, Lykousis V. Palynological investigation of the marine core SK-3 (SW Aegean Sea): implications on the vegetation of the last Interglacial. In: 11th Panhellenic Symposium of Oceanography & Fisheries. ; 2015.
Vrontaki E, Leonis G, Avramopoulos A, Papadopoulos MG, Simčič M, Grdadolnik SG, Afantitis A, Melagraki G, Hadjikakou SK, Mavromoustakos T. Stability and binding effects of silver(I) complexes at lipoxygenase-1. Journal of Enzyme Inhibition and Medicinal Chemistry [Internet]. 2015;30(4):539 - 549. Website
Varytis P, Stefanou N, Christofi A, Papanikolaou N. Strong circular dichroism of core-shell magnetoplasmonic nanoparticles. Journal of the Optical Society of America B. 2015;32(6):1063-1069.Abstract
Composite magnetoplasmonic nanoparticles with a core-shell morphology exhibit intriguing optical properties and offer impressive opportunities for tailoring in a controllable manner the light-matter interaction at subwavelength dimensions. These properties are usually analyzed in the framework of the quasi-static approximation, which, however, is often inadequate; thus, a full electrodynamic treatment is required. In this respect, we developed a rigorous method for an accurate description of electromagnetic scattering by a gyrotropic sphere coated with a nongyrotropic concentric spherical shell, based on the full multipole expansion of the wave field. The method was applied to specific examples of core-shell cobalt-silver spherical nanoparticles, where the occurrence of strong circular dichroism induced by magnetoplasmonic interaction, which largely exceeds that of homogeneous noble metal nanoparticles in an external magnetic field, was found. Our results were also explained by reference to the quasi-static approximation, which, though it reproduces the main features of the absorption spectra, strongly overestimates circular dichroism in the cases we studied.
Kankipati HN, Rubio-Texeira M, Castermans D, Diallinas G, Thevelein JM. Sul1 and Sul2 Sulfate Transceptors Signal to Protein Kinase A upon Exit of Sulfur Starvation. J Biol Chem. 2015.Abstract
Sulfate is an essential nutrient with pronounced regulatory effects on cellular metabolism and proliferation. Little is known, however, about how sulfate is sensed by cells. Sul1 and Sul2 are sulfate transporters in the yeast Saccharomyces cerevisiae, strongly induced upon sulfur starvation and endocytosed upon addition of sulfate. We reveal Sul1,2-dependent activation of protein kinase A (PKA) targets upon sulfate-induced exit from growth arrest after sulfur starvation. We provide two major arguments in favor of Sul1 and Sul2 acting as transceptors for signaling to PKA. First, the sulfate analogue, D-glucosamine 2-sulfate, acted as a non-transported agonist of signaling by Sul1 and Sul2. Second, mutagenesis to Gln of putative H+-binding residues, Glu427 in Sul1 or Glu443 in Sul2, abolished transport without affecting signaling. Hence, Sul1,2 can function as pure sulfate sensors. Sul1E427Q and Sul2E443Q are also deficient in sulfate-induced endocytosis, which can therefore be uncoupled from signaling. Overall, our data suggest that transceptors can undergo independent conformational changes each responsible for triggering different downstream processes. The Sul1 and Sul2 transceptors are the first identified plasma membrane sensors for extracellular sulfate. High-affinity transporters induced upon starvation for their substrate may generally act as transceptors during exit from starvation.
Kotopoulou I, Godelitsas A, Göttlicher J, Steininger R, Price R, Fike DA, Amend J, Gilhooly WP, Druschel GK, Mertzimekis TJ, et al. Sulfur Mineralogy and Speciation in the Shallow-Sea Hydrothermal Sediments off Milos Island (Greece). In: Goldschmidt Conference 2015, 16-21 August 2015, Prague, Czech Republic. Vol. 1670. ; 2015. Website
Zissis D, Ioannou G, Burnetas A. Supply chain coordination under discrete information asymmetries and quantity discounts. Omega (United Kingdom) [Internet]. 2015;53:21-29. WebsiteAbstract
We consider a two node supply chain with a rational manufacturer-retailer pair, in which the retailer has private information that affects the nodes[U+05F3] reservation levels. Quantity discounts offered by the manufacturer is the mechanism we propose in order to achieve reduced costs for both supply chain nodes. We derive analytical expressions of the quantity discounts that minimize the manufacturer[U+05F3]s costs, while enabling the establishment of the business. Furthermore, we show that perfect coordination is possible even under asymmetric information. Sensitivity analysis and numerical examples offer evidence of the robustness of the results and of the potential of the approach for applications to real-life business ventures. © 2014 Elsevier Ltd.
Fountoulis I, Vassilakis E, Mavroulis S, Alexopoulos J, Dilalos S, Erkeki A. Synergy of tectonic geomorphology, applied geophysics and remote sensing techniques reveals new data for active extensional tectonism in NW Peloponnese (Greece). Geomorphology [Internet]. 2015;237:52-64. Publisher's VersionAbstract
In tectonically active areas, such as in the northwest Peloponnese of western Greece, geomorphic processes are strongly influenced by active faulting; in many cases such faults cannot be easily identified. In this paper we apply multidisciplinary analysis (morphotectonic indices, neotectonic mapping, geophysical surveys and remote sensing techniques) to map the recently-recognized east–west trending Pineios River normal fault zone with a high degree of accuracy, and to better understand its contribution to the evolution of the ancient region of Elis during Holocene time. Fault activity seems to be related to frequent changes in river flow patterns and to displacements of the nearby shoreline. We argue that fault activity is the main reason for migration of Pineios river mouth as documented for several time periods during historical time. Quantitative constraints on deformation caused by the faulting were applied through the application of the morphotectonic indices proposed in this paper, including drainage network asymmetry and sinuosity, and mountain front sinuosity, all of which indicate that this is a highly active structure. Slip rates calculated to be as high as 0.48 mm/yr for the last 209 ka (based on previously published dating) were verified by applied geophysical methods. The fault surface discontinuity was identified at depth using vertical electrical resistivity measurements and depositional layers of different resistivity were found to be clearly offset. Displacement increases toward the west, reaching an observed maximum of 110 m. The most spectacular landform alteration due to surface deformation is the north–south migration of the river estuary into completely different open sea areas during the late Quaternary, mainly during the Holocene. The sediment transport path has been altered several times due to these changes in river geometry with and the most recent seeming to have occurred almost 2000 years ago. The river estuary migrated to its contemporary position along the southern coast, settled on the hanging wall, inducing retrograding of the northern coast, and settled on the foot wall, with rates reaching the order of 0.52 m/yr, as concluded from historical and recently-acquired remote sensing data.
Fountoulis I, Vassilakis E, Mavroulis S, Alexopoulos J, Dilalos S, Erkeki A. Synergy of tectonic geomorphology, applied geophysics and remote sensing techniques reveal the existence of active tectonism in NW Peloponnese (Greece). Geomorphology [Internet]. 2015;237:52-64. pdfAbstract
In tectonically active areas, such as in the northwest Peloponnese of western Greece, geomorphic processes are strongly influenced by active faulting; in many cases such faults cannot be easily identified. In this paper we apply multidisciplinary analysis (morphotectonic indices, neotectonic mapping, geophysical surveys and remote sensing techniques) to map the recently-recognized east–west trending Pineios River normal fault zone with a high degree of accuracy, and to better understand its contribution to the evolution of the ancient region of Elis during Holocene time. Fault activity seems to be related to frequent changes in river flow patterns and to displacements of the nearby shoreline. We argue that fault activity is the main reason for migration of Pineios river mouth as documented for several time periods during historical time. Quantitative constraints on deformation caused by the faulting were applied through the application of the morphotectonic indices proposed in this paper, including drainage network asymmetry and sinuosity, and mountain front sinuosity, all of which indicate that this is a highly active structure. Slip rates calculated to be as high as 0.48 mm/yr for the last 209 ka (based on previously published dating) were verified by applied geophysical methods. The fault surface discontinuity was identified at depth using vertical electrical resistivity measurements and depositional layers of different resistivity were found to be clearly offset. Displacement increases toward the west, reaching an observed maximum of 110 m. The most spectacular landform alteration due to surface deformation is the north–south migration of the river estuary into completely different open sea areas during the late Quaternary, mainly during the Holocene. The sediment transport path has been altered several times due to these changes in river geometry with and the most recent seeming to have occurred almost 2000 years ago. The river estuary migrated to its contemporary position along the southern coast, settled on the hanging wall, inducing retrograding of the northern coast, and settled on the foot wall, with rates reaching the order of 0.52 m/yr, as concluded from historical and recently-acquired remote sensing data.
Mazis I, Darras I. Systemic Geopolitical Modeling. Part 2: Subjectivity in Prediction of Geopolitical Events. GeoJournal, Spatially Integrated Social Sciences and Humanities, Springer Verlag. 2015;80(4).Abstract
This paper studies subjective priorities for the data amounts in the processing of geopolitical data according to Mazis Ioannis Th., theoretical paradigm of Systemic Geopolitical Analysis. After defining geopolitical plans and geopolitical focus sets, they are introduced geopolitical preferences and geopolitical management capacities. The geopolitical rational choice is studied, as well as the geopolitical preference -capacity distributions. Then, they are investigated geopolitical contrasts of subjective priorities by several geopolitical operators, and it is shown that there are cores and equilibrium of geopolitical contrasts, the study of which may provide useful information.
lxiv._systemic_geopolitical_modeling._part_2-_subjectivity_in_prediction_of_geopolitical_events.pdf
Bella S, Sifianou M, Tzanne A. Teaching politeness. Teaching and Learning (Im) Politeness. Edited by Berlin: Mouton de Gruyter. 2015.
Bella S, Sifianou M, Tzanne A. Teaching politeness?. In: Pizziconi, B. & Locher, M. (eds.), Teaching and Learning (Im)politeness. Berlin: Mouton de Gruyter; 2015. pp. 23-52.
Gertz MA, Terpos E, Dispenzieri A, Kumar S, Shah RA, Orlowski R, Kastritis E, Dimopoulos MA, Shah J. Therapy-related myelodysplastic syndrome/acute leukemia after multiple myeloma in the era of novel agents. Leukemia and Lymphoma [Internet]. 2015;56(6):1723 - 1726. WebsiteAbstract
Survival for patients with multiple myeloma has increased. Both melphalan and lenalidomide are associated with subsequent development of myelodysplasia. We reviewed the cases of all patients with multiple myeloma who had subsequent development of myelodysplastic syndrome (MDS) or acute non-lymphoblastic leukemia (ANLL) during a 12-year period in three centers. Of 55 patients identified, two received only lenalidomide before myelodysplasia developed. The median time between the diagnoses of multiple myeloma and MDS/ANLL was 52.7 months. Median survival after the diagnosis of MDS or ANLL was 6.7 months. Treatment of MDS comprised allogeneic stem cell transplant in eight patients (median survival, 219 days; one patient alive at 624 days) and a hypomethylating agent in 21 patients (response of stable or better in five patients). Myelodysplasia remains a devastating complication of therapy for multiple myeloma, with short survival and poor response rates to available modalities. © 2014 Informa UK, Ltd.
Vavouranakis G. Time past and time present: the transformation of the Minoan palaces as a transformation of temporality. In: Theodoropoulou-Polychroniadis Z, Evely D Aegis. Essays in Mediterranean Archaeology presented to Matti Egon by the Scholars of the Greek Archaeological committee UK. Oxford: Archaeopress; 2015. pp. 35-44.
Raptis P, Kazadzis S, Eleftheratos K, Kosmopoulos P, Amiridis V, Helmis C, Zerefos C. Total ozone column measurements using an ultraviolet multifilter radiometer. International Journal of Remote Sensing [Internet]. 2015;36(17):4469-4482. Publisher's Version a26_ijrs_2015.pdf
Lantzouraki, D.Z. STPZVJT. Total phenolic content, antioxidant capacity and phytochemical profiling of grape and pomegranate wines. RSC Advances [Internet]. 2015;5:101683-101692. Website
Matsangouras IT, Nastos PT, Kouroutzoglou J, Flocas HA, Hatzaki M. Track analysis of cyclones related to tornadoes over western Greece. Proceedings of the 14th International Conference on Environmental Science and Technology . 2015.
Mitsi E. Travel Narratives in Translation, 1750-1830: Nationalism, Ideology, Gender, (review) ed. by Alison E. Martin and Susan Pickford. mTm Minor Translating Major-Major Translating Minor-Minor Translating Minor. 2015;7:151-4.
Nooka AK, Kastritis E, Dimopoulos MA, Lonial S. Treatment options for relapsed and refractory multiple myeloma. Blood [Internet]. 2015;125(20):3085 - 3099. WebsiteAbstract
Over the last few decades, significant improvement in outcomes has been observed for myeloma patients, mainly as a result of the use of currently available approved antimyeloma agents, along with combining autologous stem cell transplantation in the treatment of myeloma. With more targeted agents in development, the treatment of a myeloma patient at relapse has become complicated and, as a consequence, results in vast heterogeneity in treatment patterns. Although a consensus on the timing of initiation of treatment, the choice of agents to be used, and the role of transplant is less clear, we describe an evidence-based approach and the factors to consider upon relapse. We describe additional newer agents and targets that are under development, with the goal of achievement of durable remissions for myeloma patients. © 2015 by The American Society of Hematology.
SAGONAS Κ, Pafilis P, Lymberakis P, Valakos ED. Trends and patterns in the feeding ecology of the widespread Balkan green lizard Lacerta trilineata (Squamata: Lacertidae) in insular and continental Greece. North-Western Journal of Zoology. 2015;11(1):117-126.
Polychroni I, Nastos P, Baltas E. Trends and variability of joint distribution extreme climate indices over Greece. 2015.
Nastos PT, KARAVANA-PAPADIMOU K, Matsangouras IT. Tropical-like cyclones in the Mediterranean: Impacts and composite daily means and anomalies of synoptic conditions. Proceedings of the 14th International Conference on Environmental Science and Technology . 2015.
Zagouri F, Terpos E, Kastritis E, Dimopoulos M-A. An update on the use of lenalidomide for the treatment of multiple myeloma. Expert Opinion on Pharmacotherapy [Internet]. 2015;16(12):1865 - 1877. WebsiteAbstract
Introduction: Lenalidomide, an immunomodulatory agent with unique mechanism of action, represents the cornerstone in the treatment of patients with multiple myeloma (MM) providing rapid and sustained control of the disease with a manageable safety profile.Areas covered: This review article, synthesizing all available data coming from trials and evaluating the efficacy and safety of lenalidomide in patients with MM, tries to provide to the clinicians with an easy-to-grasp synopsis of recent and clinically meaningful advances on the field.Expert opinion: Lenalidomide combined with dexamethasone is a safe and effective option for newly diagnosed MM patients ineligible for autologous stem cell transplantation (ASCT). Long-term administration of the agent as continuous treatment for ineligible for ASCT patients or maintenance therapy after ASCT has documented unprecedented progression-free survival improvements, whereas lenalidomide in combination with dexamethasone has shown deep and durable remissions for patients with relapsed and/or refractory disease. © 2015 Informa UK, Ltd.
Papaioannou TG, Karageorgopoulou T, Stefanadis C, Tousoulis D. Validation of Devices and Methods for Noninvasive Estimation of Central Aortic Blood Pressure in Children. Hypertension [Internet]. 2015;66(2):e7. Website
Lambrinoudaki I, Tourlakis D, Armeni E, Kaparos G, Rizos D, Augoulea A, Alexandrou A, Kreatsa M, Deligeoroglou E, Stamatelopoulos K. Variations in glomerular filtration rate are associated with subclinical atherosclerosis in healthy postmenopausal women. Menopause. 2015;22(3):317 - 324.Abstract
© 2014 by The North American Menopause Society. Objective This study aims to evaluate the potential effects of renal function variations on vascular structure before the development of hypertension. Methods This pilot study included 141 postmenopausal women without evidence of renal dysfunction or hypertension. Markers of renal function and levels of glomerular filtration rate (GFR) - using standard calculations (GFR based on levels of creatinine [GFR epi ]) and newer creatinine and/or cystatin calculations (GFR based on levels of creatinine and cystatin [GFR cr cystatin ] and GFR based on levels of cystatin [GFR cystatin ]) - were associated with hemodynamic parameters and markers of vascular structure (intima-media thickness [IMT] and presence of atheromatous plaques in carotid and femoral arteries). Results Levels of GFR epi, GFR cr cystatin, and GFR cystatin exhibited a significant negative correlation with femoral artery IMT, whereas levels of GFR epi correlated significantly with mean carotid bulb (CB) IMT. Multivariate analysis showed that CB-IMT was predicted by GFR epi levels and age (β-coefficient = -0.212, P = 0.020), whereas femoral artery IMT was predicted by GFR epi levels (β-coefficient = -0.293, P = 0.001). GFR epi levels lower than the 25th percentile were associated with higher CB-IMT (P = 0.009), femoral artery IMT (P = 0.001), and combined IMT (P = 0.035) compared with higher GFR epi levels. Moreover, GFR epi levels greater than the 25th percentile were associated with lower odds for the presence of atherosclerotic plaques at the CB and carotid arteries combined (CB: odds ratio, 0.146; P = 0.006; combined: odds ratio, 0.249; P = 0.043) compared with lower GFR epi levels. Conclusions A mild decrease in renal function within normal limits of GFR is independently associated with the presence of subclinical atherosclerosis in a sample of apparently healthy young postmenopausal women. Assessment of GFR using creatinine (vs cystatin C) levels is a more sensitive marker of its association with IMT and atherosclerotic plaques in this postmenopausal population.
Spyropoulos V, Revithiadou A, Panagiotidis P. Verbalizers leave marks: Evidence from Greek. Morphology. 2015;25(3):299-325.Abstract
In this article we provide evidence that the verbalizing v head in Greek has a morphological exponence in many more verbs than is apparent. Although, at first sight, verbs in the traditional second conjugation inflectional class (which exhibit non-root stress, e.g., aɣap-ó ‘I love’, poθ-ó ‘I desire’) do not seem to contain an overt piece of verbalizing morphology, we show that they take a vocalic extension consisting of an abstract vocalic slot. This slot, which can either be filled in with vocalic material or remain empty, undertakes the function of a verbalizer. Two major gains of this analysis is that it provides solid evidence for a v head as a verbalizer and not as a composite Voice-verbalizing head and that it proposes a unified treatment of the Greek verb morphology without extensively retreating to stem allomorphy.
Papachristopoulou K, Matsangouras IT, Nastos PT. Waterspout cloud top detection using MSG SEVIRI infrared brightness temperature over the northern Ionian Sea, Greece. Advances in Science and Research. 2015;12:45–49.
Despotopoulou A. Women and the Railway, 1850-1915. Edinburgh University Press; 2015 pp. 202. Publisher's Version
Kamberidou I. Women’s sport and social entrepreneurship in times of crisis. Presentation at the Sport & Society Workshop, March 14, 2015, organized by the Theoretical and Social Science Department of the School of Physical Education and Sport Science, University of Athens (UOA) [in Greek]. 2015. sport_and_social_entrepreneurs_1.3.2015.pdf
Athanasiou, M., Triantaphyllou, M., Dimiza, M., Gogou, A., Τheodorou G. Zanclean/Piacenzian transition on Cyprus (SE Mediterranean): calcareous nannofossil evidence of sapropel formation. Geo-Marine Letters [Internet]. 2015;35:367-385. Publisher's VersionAbstract
Quantitative analyses of calcareous nannofossils in the sediments of Pissouri South section on the island of Cyprus have produced a paleoceanographic record reflecting the paleoclimatic conditions during the Zanclean/Piacenzian transition. Pissouri South cyclical lithological alternations between organic-rich laminated layers and grey marls reflect the Earth’s orbital precession. According to the calcareous nannofossil biostratigraphy which has been performed, the studied section is correlated with MNN14/15 and MNN16 calcareous nannofossil biozones and is astronomically dated between 4.065 and 3.217 Ma. Intervals of increased organic carbon content, along with the positive values ofFlorisphaera profunda, Helicosphaera sellii, Discoaster spp. and the subsequent increase of stratification S-index, correspond to the sapropel deposition during periods of wetter climate and intense continental runoff, especially from the river Nile. These layers alternate with grey marly intervals, featured by the increased values of small placoliths of Reticulofenestra and Gephyrocapsaspecies, which are indicative of eutrophic conditions during intense surface-water mixing. Our data support the prevalence of a generally warm phase characterized by the absence of high-frequency climate variations in the southeastern Mediterranean during the Zanclean/Piacenzian (Early/Late Pliocene) transition.
Athanasiou, M., Triantaphyllou, M., Dimiza, M., Gogou, A., Τheodorou G. Zanclean/Piacenzian transition on Cyprus (SE Mediterranean): calcareous nannofossil evidence of sapropel formation. Geo-Marine Letters [Internet]. 2015;35:367-385. Publisher's VersionAbstract
Quantitative analyses of calcareous nannofossils in the sediments of Pissouri South section on the island of Cyprus have produced a paleoceanographic record reflecting the paleoclimatic conditions during the Zanclean/Piacenzian transition. Pissouri South cyclical lithological alternations between organic-rich laminated layers and grey marls reflect the Earth’s orbital precession. According to the calcareous nannofossil biostratigraphy which has been performed, the studied section is correlated with MNN14/15 and MNN16 calcareous nannofossil biozones and is astronomically dated between 4.065 and 3.217 Ma. Intervals of increased organic carbon content, along with the positive values ofFlorisphaera profunda, Helicosphaera sellii, Discoaster spp. and the subsequent increase of stratification S-index, correspond to the sapropel deposition during periods of wetter climate and intense continental runoff, especially from the river Nile. These layers alternate with grey marly intervals, featured by the increased values of small placoliths of Reticulofenestra and Gephyrocapsaspecies, which are indicative of eutrophic conditions during intense surface-water mixing. Our data support the prevalence of a generally warm phase characterized by the absence of high-frequency climate variations in the southeastern Mediterranean during the Zanclean/Piacenzian (Early/Late Pliocene) transition.
Βαβουρανάκης Γιώργος. Ανάκτορο και κράτος στη μινωική Κρήτη: η σημασία της κοινωνικής αναπαραγωγής. In: Urban Conflicts. Θεσσαλονίκη: Urban Conflicts; 2015. pp. 61-72. Publisher's Version
Γαρδίκα Κατερίνα. Ανατολικό Ζήτημα. Σύντομη εισαγωγή. In: Σατιρικοί χάρτες. Ιστορικές και σατιρικές απεικονίσεις της Ευρώπης (19ος-20ός αι.). Π. Σουκάκος (επ.). Αθήνα: Μίλητος; 2015.
Αρνητικές-ερωτηματικές προσκλήσεις: συνέπειες για τη δομή προτίμησης
Μπέλλα Σπυριδούλα, Μόζερ Αμαλία. Αρνητικές-ερωτηματικές προσκλήσεις: συνέπειες για τη δομή προτίμησης. In: Θ.-Σ. Παυλίδου (επιμ.) Ελληνική γλώσσα και προφορική επικοινωνία. Θεσσαλονίκη: Ίδρυμα Νεοελληνικών Σπουδών - Ινστιτούτο Μανόλη Τριανταφυλλίδη; 2015. pp. 11-22. Publisher's Version
Αρνητικές-ερωτηματικές προσκλήσεις: συνέπειες για τη δομή προτίμησης
Μπέλλα Σπυριδούλα, Μόζερ Αμαλία. Αρνητικές-ερωτηματικές προσκλήσεις: συνέπειες για τη δομή προτίμησης. In: Θ.-Σ. Παυλίδου (επιμ.) Ελληνική γλώσσα και προφορική επικοινωνία. Θεσσαλονίκη: Ίδρυμα Νεοελληνικών Σπουδών - Ινστιτούτο Μανόλη Τριανταφυλλίδη; 2015. pp. 11-22. Publisher's Version
Καμπερίδου Ειρήνη. Γυναίκα και Τεχνολογία: η Ελληνική πραγματικότητα. In: Η Τεχνολογία στην Υπηρεσία των Γυναικών, Δημαρχείο Λυκόβρυσης-Πεύκης, 28/9/2015. Διοργάνωση: Δίκτυο Επαγγελματιών Πληροφορικής (HePIS) με τη στήριξη του Δήμου Λυκόβρυσης-Πεύκης και του ECWT – European Centre for Women and Technology.eu. ; 2015.Abstract
Καμπερίδου, Ειρήνη (2015). «Γυναίκα και Τεχνολογία: η Ελληνική πραγματικότητα». Εισήγηση  στο συνέδριο "Active Women":  Η Τεχνολογία στην Υπηρεσία των Γυναικών,   Δημαρχείο Λυκόβρυσης-Πεύκης,  28/9/2015.  Διοργάνωση: Δίκτυο Επαγγελματιών Πληροφορικής (HePIS) με τη στήριξη του Δήμου Λυκόβρυσης-Πεύκης και του  ECWT – European Centre for Women and Technology (http://www.ecwt.eu) https://www.facebook.com/media/set/?set=a.895337420552195.1073741905.100002278359788&type=1&l=e35f9250fa   Kamberidou, Irene (2015).  “Women and Technology in Greek society”. Presentation at the conference  “Active Women”: Technology in the Service of Women, at the Municipality of Lykovirtssi-Pefki, Greece, Sept. 28, 2015. Organized by the Hellenic Professionals Informatics Society (HePIS) with the support of the ECWT and the Municipality of Lykovrisi-Pefki. [presentation in Greek] https://www.facebook.com/media/set/?set=a.895337420552195.1073741905.100002278359788&type=1&l=e35f9250fa  
active_women_ppt._presentation_sept._28_2015.pdf active_women_photo.jpg omilites.speakers._active_women.pdf
Σκορδούλης Κώστας. ΕΠΙΣΤΗΜΟΝΙΚΗ ΓΝΩΣΗ. Paperback. Αθήνα: ΤΟΠΟΣ; 2015 pp. 317. Publisher's VersionAbstract
Στόχος του βιβλίου είναι η σύνδεση γνωσιοθεωρίας και φιλοσοφίας της επιστήμης με τη διδακτική μεθοδολογία των φυσικών επιστημών. Η πορεία από τη γνωσιοθεωρία και τη φιλοσοφία της επιστήμης, που σκιαγραφείται στις σελίδες του βιβλίου, εκβάλλει στα προγράμματα τα οποία σχεδιάζονται σήμερα για την εκπαίδευση των φυσικών επιστημών: (α) στο πρόγραμμα που βασίζεται στη συμβολή της ιστορίας και της φιλοσοφίας των επιστημών στη διδασκαλία των φυσικών επιστημών το οποίο στις μέρες μας επικεντρώνεται στη διδασκαλία για τη φύση της επιστήμης, και (β) στο πρόγραμμα που βασίζεται στη θεώρηση για την αλληλεπίδραση της επιστήμης με την τεχνολογία και την κοινωνία και το οποίο μετεξελίσσεται ενσωματώνοντας στοιχεία από την πολιτισμική προσέγγιση και την κριτική θεωρία.
Καμπερίδου Ειρήνη. Η Γυναικεία Αθλητική και Κοινωνική Επιχειρηματικότητα στην Εποχή της Κρίσης: Ενδυνάμωση Ηγετικών Δεξιοτήτων & Αθλητισμός. Εισήγηση στην Ημερίδα ΑΘΛΗΤΙΣΜΟΣ & ΚΟΙΝΩΝΙΑ του Τομέα Θεωρητικών Επιστημών της Σ.Ε.ΦΑ.Α., Πανεπιστήμιο Αθηνών. 2015.Abstract
When citing/ για παραπομπή:   Καμπερίδου, Ειρήνη (2015). «Η Γυναικεία Αθλητική και Κοινωνική Επιχειρηματικότητα στην Εποχή της Κρίσης: Ενδυνάμωση Ηγετικών Δεξιοτήτων & Αθλητισμός». Εισήγηση στην Ημερίδα ΑΘΛΗΤΙΣΜΟΣ ΚΑΙ ΚΟΙΝΩΝΙΑ, του Τομέα Θεωρητικών Επιστημών της Σχολής Επιστήμης, Φυσικής Αγωγής και Αθλητισμού (Σ.Ε.Φ.Α.Α.), ΤΕΦΑΑ του Πανεπιστημίου Αθηνών (ΕΚΠΑ), 14/03/2015, Δάφνη  ***Kamberidou, I. (2015). “Women’s sport and social entrepreneurship in times of crisis: empowering leadership skills & Sport”. Presentation at the Sport & Society Workshop, March 14, 2015, organized by the Theoretical and Social Sciences Department of the School of Physical Education and Sport Science, University of Athens (UOA) [in Greek]. sport_and_social_entrepreneurs_1.3.2015.pdf
sport_and_social_entrepreneurs_1.3.2015.pdf
Tsoukos A, Drikos S, Kountouris P, Veligekas P, Bogdanis G. Η ΚΑΤΑΚΟΡΥΦΗ ΑΛΤΙΚΗ ΙΚΑΝΟΤΗΤΑ ΩΣ ΠΑΡΑΓΟΝΤΑΣ ΠΡΟΒΛΕΨΗΣ ΓΙΑ ΤΗΝ ΕΠΙΛΟΓΗ ΝΕΑΡΩΝ ΠΕΤΟΣΦΑΙΡΙΣΤΩΝ. In: 3o Συνέδριο Αθλητικής Επιστήμης, «Απόδοση ασκουμένων, αθλητών, πρωταθλητών». ΣΕΦΑΑ Αθήνας, 8-10 Μαΐου 2015, Αθήνα. http://sefaacongress.phed.uoa.gr/: School of Physical Education & Sport Science ATHENS; 2015. pp. 33. Publisher's VersionAbstract
Εισαγωγή: Η Πετοσφαίριση είναι ένα άθλημα το οποίο απαιτεί συνεχείς επαναλαμβανόμενες προσπάθειες υψηλής έντασης (Kuslinger et al, 1987) ενώ παράλληλα περιλαμβάνει πολλές κινητικές δεξιότητες. Σύμφωνα με τους Ziv & Lidor (2010) η σημαντικότερη παράμετρος στην Πετοσφαίριση είναι το κατακόρυφο άλμα. Σε αντίθεση οι Gabbett et al (2007) απέδειξαν ότι οι τεχνικές επιδεξιότητες συνεισφέρουν περισσότερο καθώς μπορούν να προβλέπουν καλύτερα την επιλογή ή όχι εφήβων ταλαντούχων παικτών. Σκοπός της παρούσας μελέτης ήταν να προσδιοριστούν οι μεταβλητές που σχετίζονται περισσότερομε την επιλογή νεαρών πετοσφαιριστών για την Εθνική ομάδα Παμπαίδων (14-15ετών).Μέθοδος: Το δείγμα αποτέλεσαν αθλητές της κατηγορίας Παμπαίδων (n=43) οι οποίοι υποβλήθηκαν σε σωματομετρήσεις (σωματικό ύψος και βάρος, ύψος με το χέρι στην ανάταση, σωματικό λίπος) και κινητικά τεστ (κατακόρυφο άλμα (CMJ), άλμα μπλοκ, άλμα επίθεσης, τεστ ευκινησίας 505, δρόμος ταχύτητας 10m). Τέσσερις έμπειροι προπονητές βαθμολόγησαν τον κάθε παίκτη με κλίμακα 0-100κατά τη διάρκεια αγώνων διαχωρίζοντας τους αθλητές σε επιλεγόμενους και μη. Πραγματοποιήθηκε διακριτική ανάλυση για να εκτιμήσει ποιές αξιολογούμενες μεταβλητές μπορούν να προβλέψουν την εκτίμηση των προπονητών. Αποτελέσματα: Από την ανάλυση προέκυψε μια διακριτική συνάρτηση που διαχώρισε σημαντικά τις ομάδες (λ=0.69; Χ2=15.12; p=0.001; η2=0.12). Το κατακόρυφο άλμα (CMJ) ήταν η μόνη σημαντική παράμετρος που φόρτισε τη συνάρτηση (r=0.85). Η ακρίβεια της διακριτικής εξίσωσης ήταν υψηλή καθώς το ποσοστό σωστού διαχωρισμού με την προσέγγιση της διασταυρούμενης επικύρωσης ήταν 72.1%. Συζήτηση: Τα αποτελέσματα της μελέτης δείχνουν ότι το κατακόρυφο άλμα μπορεί να διαχωρίσει με επιτυχία νεαρούς Πετοσφαιριστές ηλικίας 14-15 ετών σε επιλεγόμενους ή μη για το επίπεδο Εθνικής ομάδας Παμπαίδων και ίσως αποτελεί τη σημαντικότερη παράμετρο αξιολόγησης στην εύρεση νέων ταλέντων στην Πετοσφαίριση.
Μάζης Ιωάννης. Ἡ συμπεριφορὰ τῆς Τουρκίας. Πῶς ἀντιδρᾷ ἡ γείτων στὴν σύγχρονο γεωπολιτικὴ συγκυρία. Foreign Affairs: The Hellenic Edition. 2015.Abstract
Ἡ τουρκικὴ πολιτικὴ ἡγεσία Νταβούτογλου-Ἐρντογὰν (μὲ αὐτὴν τὴν ἱεραρχικὴ σειρά), ἀντιλαμβάνεται τήν, σὲ βάθος χρόνου, μείωση τῆς στρατηγικῆς σημασίας τῆς Τουρκίας γιὰ τὴν ∆ύση καὶ τὸ ΝΑΤΟ. Ἡ μείωσις αὐτὴ ὀφείλεται στὴν τήξη τῶν πάγων κατὰ μῆκος τοῦ Βορειοανατολικοῦ Περάσματος (Βερίγγειος Πορθμὸς) ποὺ θὰ ἐπιτρέπει σὲ μερικὰ χρόνια στὴν Ρωσσία νὰ πρoσεγγίζει τὰ στρατηγικὰ σημεῖα τοῦ Εἰρηνικοῦ σὲ τρεῖς φορὲς ὀλιγώτερον χρόνο ἀφ' ὅτι οἱ ΗΠΑ. Τὸ γεγονὸς αὐτὸ ὑπονομεύει, προϊόντος τοῦ χρόνου, τὴν σπουδαιότητα τῆς Τουρκίας ὡς ἀνασχετικοῦ παράγοντος (μαζῇ μὲ τὴν Ἑλλάδα), τῆς καθόδου τῆς Ρωσσίας στὰ θερμὰ ὕδατα τῆς Μεσογείου καὶ μειώνει σὲ σημαντικὸ βαθμὸ τὸν συνολικὸ ρόλο τῆς Νοτιοανατολικῆς Πτέρυγος τοῦ ΝΑΤΟ. Ἕνα ρόλο ὁ ὁποῖος ἐπικοινωνιακῶς καλύπτεται ἀπὸ τὸ ἠθικο-ἰδεολογικὸ «emballage» τῆς «ἑλληνοτουρκικῆς φιλίας». Μιᾶς φιλίας ποὺ δὲν παύει νὰ δοκιμάζεται ἀπὸ τὴν Ἄγκυρα στὸ Αἰγαῖο Πέλαγος καὶ στὴν ΑΟΖ / ΕΕΖ τῆς, ὑπὸ τουρκικὴν κατοχὴ κατὰ τὸ 38% τοῦ ἐδάφους της, Κυπριακῆς ∆ημοκρατίας, κράτους-μέλους τῆς ΕΕ. Το παρόν άρθρο, περιγράφει τη συμπεριφορά της Τουρκίας στη σύγχρονη γεωπολιτική συγκυρία.
2._xv.pdf
Καμπερίδου Ειρήνη, Παπαδοπούλου Σοφία. Κοινωνικό Κεφάλαιο, Φύλο και Αθλητισμός. Γυναίκα & Άθληση. 2015;9(2013/2014):7-14.Abstract
Καμπερίδου, Ειρήνη; Παπαδοπούλου, Σοφία (2014). Κοινωνικό Κεφάλαιο, Φύλο και Αθλητισμός. Γυναίκα & Άθληση. Τόμος  ΙΧ , 2013/2014, σελ. 7-14. Έκδοση της Πανελλήνιας Ένωσης για τον Αθλητισμό και τα Σπορ (ΠΕΠΓΑΣ).       *** Kamberidou, I. ; Papadopoulou, Sophia (2014). Social Capital, Gender and Sport (published in Greek). Women & Sport, a publication of the Hellenic Union for the Advancement of Women and Girls in Sport (PEPGAS), volume ΙΧ , 2013/2014, σελ. 7-14.
kamberidou_papad.pdf journal_cover_women_and_sports._exofyllo.pdf
Παυλόπουλος Β, Ντάλλα Μ, Μόττη-Στεφανίδη Φ. Μετανάστευση. In: Παιδιά και έφηβοι σε έναν κόσμο που αλλάζει: Προκλήσεις, προσαρμογή και ανάπτυξη. Αθήνα: Βιβλιοπωλείον της Εστίας; 2015. pp. 77-128. pdf
Βαβουρανάκης Γιώργος. Ο ΠΜ-ΜΜ θολωτός τάφος Β στο Απεσωκάρι Μεσαράς: Τα αποτελέσματα των εργασιών των ετών 2012 και 2013. In: Καραναστάση Παυλίνα, Τζιγκουνάκη Αναστασία, Τσιγωνάκη Χριστίνα Αρχαιολογικό Έργο Κρήτης. Πρακτικά της 3ης Συνάντησης. Ρέθυμνο: Εκδόσεις Φιλοσοφικής Σχολής Πανεπιστημίου Κρήτης – Εφορεία Αρχαιοτήτων Ρεθύμνου; 2015. pp. 217-226.
Μάζης Ιωάννης, Πατραγάς Κυριάκος Ν. Ὁ ρόλος τῶν παλαιφάτων ὀρθοδόξων πατριαρχείων εἰς τὸν ἰσλαμικὸν κόσμον. Ἐφημερίδα Δημοσίου Δικαίου. 2015.Abstract
Το παρόν κείμενο αποτελεί άρθρο του Καθηγητή Ιωάννη Μάζη, σε συνεργασία με τον Κυριάκο Πατραγά και αναφέρεται, στο ρόλο τῶν παλαιφάτων ὀρθοδόξων πατριαρχείων, στον ἰσλαμικὸ κόσμο.
4._vi.pdf
Κουμαριανός Θεόδωρος Ι. «Οι Ακολουθίες τού Νυχθημέρου στην ασματική παράδοση τής Αγίας Σοφίας». In: ΙΕ΄ Πανελλήνιο Λειτουργικό Συμπόσιο Στελεχών Ιερών Mητροπόλεων, Καισαριανή, Σεπτέμβριος 2014. «Οι Ακολουθίες τού Νυχθημέρου». Αποστολική Διακονία τής Εκκλησίας τής Ελλάδος; 2015. pp. 294-342.
Πασιάς Γεώργιος, Φλουρής Γεώργιος, Φωτεινός Δημήτριος. Παιδαγωγική και Εκπαίδευση. 1st ed. Athens, Greece: Γρηγόρης; 2015 pp. 600.
Βαβουρανάκης Γιώργος. Πέρα από την αντίθεση κράτους και ιδιωτών στη διεξαγωγή αρχαιολογικού έργου: Προς ένα δημόσιο πλαίσιο γνώσης. In: Αντωνιάδου Σοφία, Μαυραγάνη Ελένη, Πούλιος Ιωάννης Πολιτισμός και προοπτική. Η σημασία της στρατηγικής σε τέσσερις τομείς του πολιτισμού. Αθήνα: Εκδόσεις Καστανιώτη; 2015. pp. 91-96.
Πραγματολογία: Από τη γλωσσική επικοινωνία στη γλωσσική διδασκαλία [Pragmatics: from Linguistic Communnication to the Language Teaching]
Bella S. Πραγματολογία: Από τη γλωσσική επικοινωνία στη γλωσσική διδασκαλία [Pragmatics: from Linguistic Communnication to the Language Teaching]. Athens: Gutenberg; 2015 pp. 288.
Σκέψεις με αφορμή την απόφαση του ΣτΕ (Ολ.) 2287/2015 για τις περικοπές των επικουρικών συντάξεων. Θεωρία και Πράξη Δημοσίου Δικαίου. 2015;2015(7):674-679.Abstract
Η απόφαση της ΣτΕ (Ολ.) 2287/2015 κρίνει ότι επιβάλλεται η εκπόνηση μελέτης οικονομικών και κοινωνικών επιπτώσεων πριν από την επιβολή περικοπών στις συντάξεις. Απαιτείται να εκτιμηθούν συνολικά οι επιπτώσεις από τα φορολογικά και ασφαλιστικά μέτρα. Η απόφαση συνάδει με όσα έχουν γίνει δεκτά από τον Διεθνή Οργανισμό Εργασίας και το Συμβούλιο της Ευρώπης όσον αφορά στη συμμόρφωση της Ελλάδας στις διεθνείς της υποχρεώσεις. Ωστόσο, η απόφαση εσφαλμένα δέχεται ότι τα μέτρα που έχουν ληφθεί κατά τη διάρκεια της κρίσης δεν είναι διαρθρωτικά. Η άποψη της μειοψηφίας στο σημείο αυτό είναι περισσότερο πειστική. Τέλος, στην παρούσα εξαιρετικά κρίσιμη οικονομική συγκυρία και λαμβάνοντας υπόψη ότι η αναφερόμενη στην απόφαση μελέτη των επιπτώσεων απαιτείται το πρώτον, θα έπρεπε να είχε ταχθεί προθεσμία στο Δημόσιο για να προσκομίσει, έστω και εκ των υστέρων, ως συμπληρωματική απόδειξη τη μελέτη αυτή.
skepseis_me_aformi_ti_ste_ol_2287_2015.pdf
Καμπερίδου Ειρήνη, Kamberidou I. Στο Θερμοκήπιο του Ανταγωνισμού και της Αντιζηλίας - In the yoke of the harem- hotbed of rivalry and jealousy. Παρουσίαση στο Πνευματικό Κέντρο «Εκάβη», διοργάνωση: Λύκειο των Ελληνίδων Κατερίνης, στο πλαίσιο της παρουσίασης του βιβλίου "Επιτέλους. 2015.Abstract
  1. Καμπερίδου, Ειρήνη (2015). Στο Θερμοκήπιο του Ανταγωνισμού και της Αντιζηλίας  [In the yoke of the harem- hotbed of rivalry and jealousy]. Παρουσίαση στο Πνευματικό Κέντρο «Εκάβη», διοργάνωση: Λύκειο των Ελληνίδων Κατερίνης, στο πλαίσιο της παρουσίασης του βιβλίου "Επιτέλους Αναπνέω Ελεύθερη! Γυναικείες Μαρτυρίες"       *** Kamberidou, Irene (2015). In the yoke of the harem- hotbed of rivalry and jealousy.  Presentation at the Cultural Center EKAVI,  Katerini, Greece  on the occasions of the circulation of Irene Kamberidou’s book entitled  "Finally Free to Breathe", Women’s Accounts: women travellers of the 17th, 18th and 19th centuries. Publisher: Telethrio S.A., Athens
Μάζης Ιωάννης. Σχόλια ἑνὸς γεωπολιτικοῦ ἐπὶ μιᾶς νομικοφανοῦς πολιτικῆς διαδικασίας ἢ Ἡ διὰ τῆς ΔΔΟ Ὑπονόμευσις τῆς Διεθνοῦς Ἐννόμου Τάξεως καὶ τοῦ κύρους τοῦ Διεθνοῦς Δικαίου.

In: Ἡμερίδα Ε∆ΕΚ. Λευκωσία-Κυπριακὴ ∆ημοκρατία.; 2015.Abstract
Στὴν παροῦσα Εἰσήγηση ἀναφερόμεθα καὶ ἐμβαθύνομε σὲ ὡρισμένες πτυχὲς τοῦ ζητήματος τῆς ἐπιλύσεως τοῦ Κυπριακοῦ ἀναφορικῶς πρὸς τὰ Πλάσματα ∆ικαίου τὰ χρησιμοποιούμενα ἀπὸ φορεῖς τῆς διεθνοῦς, λεγομένης, κοινότητος πρὸς ἐπίλυσιν τοῦ Κυπριακοῦ μέσῳ τῆς λεγομένης ∆∆Ο, ὅπως καὶ τὰ ∆ιεθνῆ ἐγκλήματα ποὺ τὰ ἀνωτέρω πλάσματα δικαίου συγκαλύπτουν καὶ νομιμοποιοῦν, μὲ ἀποτέλεσμα νὰ δημιουργοῦν προϋποθέσεις γιὰ χαοτικὴ διχοτόμηση στὴν καταργηθησομένη "μετεξελιχθεῖσα" Κυπριακὴ ∆ημοκρατία. 1) Ὑποστηρίζομε ὅτι βασικοὶ πυλῶνες τῶν διαφόρων σχεδίων καὶ προτάσεων ἐπιλύσεως τοῦ Κυπριακοῦ, οἱ ὁποῖοι διαχρονικῶς ἀποτελοῦν τὴν βάση τῶν διαπραγματεύσεων, συνιστοῦν δικαϊκὰ πλάσματα. Θὰ παρουσιασθεῖ τί μπορεῖ νὰ ὑποδηλώνει ἡ ἀνάγκη χρήσεως τόσων πλασμάτων δικαίου, καὶ μάλιστα ἐπὶ θεμελιωδῶν ρυθμίσεων ἐπιλύσεως τοῦ Κυπριακοῦ, καὶ πῶς μπορεῖ τὸ γεγονὸς αὐτὸ νὰ ἐπηρεάσει τὴν λειτουργικότητα τοῦ προτεινομένου ὑποδείγματος ἱδρύσεως καὶ διακυβερνήσεως. 2) Παραλλήλως, ἐξετάζεται τὸ ζήτημα τῆς ἐκ τῶν ὑστέρων νομιμοποιήσεως παρανόμων καταστάσεων καὶ πῶς ἡ διαχείρισις καὶ ἐπίλυσις τοῦ Κυπριακοῦ μπορεῖ νὰ λειτουργήσει δικαιοπαραγωγικῶς. 3) Ἐπὶ πλέον, ἀναλύεται τὸ ζήτημα τῆς συνεχίσεως ἢ διαδοχῆς τῆς Κυπριακῆς ∆ημοκρατίας, καὶ ἐξετάζεται τὶ μπορεῖ νὰ συνεπάγεται γιὰ τὴν νομικὴ ἀντιμετώπιση τῶν τελεσθέντων ἀπὸ τὴν τουρκικὴ πλευρὰ διεθνῶν ἐγκλημάτων στὴν Κύπρο.
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Κουμαριανός Θεόδωρος Ι. «Το Ευχολόγιον». In: ΙΔ΄ Πανελλήνιο Λειτουργικό Συμπόσιο Στελεχών Ιερών Mητροπόλεων, Πάτρα, Σεπτέμβριος 2012. «Οι λειτουργικές τέχνες». Αποστολική Διακονία τής Εκκλησίας τής Ελλάδος, Αθήναι; 2015. pp. 123-143.
Κουκουνάρας- Λιάγκης Μάριος. Φιλοσοφία του Αναλυτικού Προγράμματος Σπουδών: Συμβολή στον σχεδιασμό της Θρησκευτικής Εκπαίδευσης στο Λύκειο. Εκπαιδευτικός Κύκλος. 2015;3(1):139-153. 9.pdf
2014
Mavromoustakos T, Tsotinis A. 32nd cyprus-noordwijkerhout-camerino symposium: Trends in drug research 2014. ChemMedChem [Internet]. 2014;9(8):1903 - 1905. Website
Konstantinidou AE, Vrasidas C, Armenski G, Brcik L, Smeets A, Antovski L, Thomopoulou GE, Petrusevska G, Seiwerth S, van Krieken H. Acquiring diagnostic experience in placenta pathology through HIPON web course. Pathology. 2014;46:S124.
Vernadakis S, Moris D, Papadopoulos IN. Acute abdominal pain due to intussusception of the small intestine in a 17-year-old patient. Surgery (United States). 2014;156:1282-1283.
de Silva D, Geromi M, Panesar SS, Muraro A, Werfel T, Hoffmann-Sommergruber K, Roberts G, Cardona V, Dubois AEJ, Halken S, et al. Acute and long-term management of food allergy: systematic review. Allergy. 2014;69(2):159-67.Abstract
BACKGROUND: Allergic reactions to food can have serious consequences. This systematic review summarizes evidence about the immediate management of reactions and longer-term approaches to minimize adverse impacts. METHODS: Seven bibliographic databases were searched from their inception to September 30, 2012, for systematic reviews, randomized controlled trials, quasi-randomized controlled trials, controlled clinical trials, controlled before-and-after and interrupted time series studies. Experts were consulted for additional studies. There was no language or geographic restrictions. Two reviewers critically appraised the studies using the appropriate tools. Data were not suitable for meta-analysis due to heterogeneity so were narratively synthesized. RESULTS: Eighty-four studies were included, but two-thirds were at high risk of potential bias. There was little evidence about acute management for non-life-threatening reactions. H1-antihistamines may be of benefit, but this evidence was in part derived from studies on those with cross-reactive birch pollen allergy. Regarding long-term management, avoiding the allergenic food or substituting an alternative was commonly recommended, but apart from for infants with cow's milk allergy, there was little high-quality research on this management approach. To reduce symptoms in children with cow's milk allergy, there was evidence to recommend alternatives such as extensively hydrolyzed formula. Supplements such as probiotics have not proved helpful, but allergen-specific immunotherapy may be disease modifying and therefore warrants further exploration. CONCLUSIONS: Food allergy can be debilitating and affects a significant number of people. However, the evidence base about acute and longer-term management is weak and needs to be strengthened as a matter of priority.
Kokras N, Pastromas N, Porto TH, Kafetzopoulos V, Mavridis T, Dalla C. Acute but not sustained aromatase inhibition displays antidepressant properties. Int J Neuropsychopharmacol. 2014;17(8):1307-13.Abstract
Aromatase inhibitors block the conversion of androgens to oestrogens and are used for the treatment of hormone-responsive breast cancer in menopause and recently also in premenopausal women. We investigate whether decreased oestrogen synthesis following aromatase inhibition leads to a depressive-like behavioural response in cycling female rats. Using the forced swim test (FST) we estimate the response of acute (three injections in 24 h) and sustained (7 d) letrozole and fluoxetine administration. Acute aromatase inhibition decreases immobility duration in the FST, indicating its antidepressant potential. Instead, sustained aromatase inhibition did not show such antidepressant potential. Testosterone elevation associates with the decreased depressive behaviour in the FST following acute letrozole treatment, but interestingly progesterone explains the increased swimming behaviour. Present findings may have potential implications for women treated with aromatase inhibitors, especially before menopause, as well as for the role of gonadal hormones in the expression of depressive symptoms and antidepressant response.
Triantaphyllou, M.V. /, Dimiza, M., Karatsolis, B. Adding proofs toSyracosphaera histrica-Calyptrolithophora pappiliferalife-cycle association. Journal of Nannoplankton Research [Internet]. 2014;34:57-59. Publisher's VersionAbstract
Two specimens of the coccolithophore Calyptrolithophora pappilifera associated with single exothecal and endothecal coccoliths of Syracosphaera histrica, collected from the North Aegean Sea (NE Mediterranean), have been verified by Scanning Electron Microscopy. The two specimens strengthen previous reported hints that Syracosphaera histrica and Calyptrolithophora pappilifera represent a life-cycle association, documenting accordingly the relationships between the different phases within the genus Syracosphaera.
Kostarelou, P. KPK-GMAIE. Aflatoxin B1 production by Aspergillus parasiticus and strains of Aspergillus section Nigri in currants of Greek origin. Food Control [Internet]. 2014;43:121-128. Website
Tavoulari, M. KPK-GMAIE. Aflatoxin B1 production by Aspergillus section Nigri strains isolated from greek dried vine fruits and competition with Aspergillus parasiticus. Fresenius Environmental Bulletin [Internet]. 2014;23:1744-1753. Website
Moustris KP, Proias GT, Larissi IK, Nastos PT, Koukouletsos KV, Paliatsos AG. AIR QUALITY PROGNOSIS USING ARTIFICIAL NEURAL NETWORKS MODELING IN THE URBAN ENVIRONMENT OF VOLOS, CENTRAL GREECE. FRESENIUS ENVIRONMENTAL BULLETIN. 2014;23:2967–2975.
Gu Y, Scarmeas N, Short EE, Luchsinger JA, DeCarli C, Stern Y, Manly JJ, Schupf N, Mayeux R, Brickman AM. Alcohol intake and brain structure in a multiethnic elderly cohort. Clin Nutr. 2014;33(4):662-7.Abstract
BACKGROUND & AIMS: Evidence suggests that consuming light-to-moderate amounts of alcohol reduces the risk of dementia and is associated better cognitive function and less cardiovascular disease, relative to those consuming no or heavy alcohol. There are only minimal data on the association between alcohol and brain magnetic resonance imaging (MRI) markers. This study aimed to examine the association between alcohol and brain structure measured with MRI. METHODS: In this cross-sectional study, high-resolution structural MRI was collected on 589 multi-ethnic community residents of New York aged ≥65 with available alcohol intake assessments via a food frequency questionnaire. Total brain volume (TBV), white matter hyperintensity volume (WMHV), and presence of infarcts were derived from MRI scans with established methods. We examined the association of alcohol intake with these imaging markers using regression models adjusted for demographic, clinical, and vascular risk factors. RESULTS: Compared to non-drinking, light-to-moderate total alcohol (b = 0.007, p = 0.04) or wine (b = 0.008, p = 0.05) intake, but not beer or liquor intake, was associated with larger TBV. Further analysis showed a dose-response association between alcohol (p-trend = 0.03) or wine (p-trend = 0.006) and TBV. Overall, alcohol intake was not associated with WMHV or brain infarcts. CONCLUSIONS: Our study suggests that among older adults in the community, light-to-moderate alcohol intake, in particular wine, is associated with larger TBV. These findings suggest that light to moderate alcohol consumption is potentially beneficial for brain aging, but replication is needed.
Nieto A, Wahn U, Bufe A, Eigenmann P, Halken S, Hedlin G, Høst A, Hourihane J, Just J, Lack G, et al. Allergy and asthma prevention 2014. Pediatr Allergy Immunol. 2014.Abstract
Asthma and allergic diseases have become one of the epidemics of the 21st century in developed countries. Much of the success of other areas of Medicine, such as infectious diseases, lies on preventive measures. Thus, much effort is also being placed lately in the prevention of asthma and allergy. This manuscript reviews the current evidence, divided in four areas of activity. Interventions modifying environmental exposure to allergens have provided inconsistent results, with multifaceted interventions being more effective in the prevention of asthma. Regarding nutrition, the use of hydrolysed formulas in high risk infants reduces the incidence of atopic dermatitis, while there is for now not enough evidence to recommend other dietary modifications, prebiotics, probiotics, or other microbial products. Pharmacologic agents used until now for prevention have not proved useful, while there is hope that antiviral vaccines could be useful in the future. Allergen-specific immunotherapy is effective for the treatment of allergic patients with symptoms; the study of its value for primary and secondary prevention of asthma and allergy is in its very preliminary phases. The lack of success in the prevention of these disorders lies on their complexity, which involves many genetic, epigenetic and environmental interactions. There is a need to identify target populations, involved mechanisms and interactions, and the best interventions. These must be effective, feasible, implementable and affordable. This article is protected by copyright. All rights reserved.
Nastos PT, Matsangouras IT. Analysis of synoptic conditions for tornadic days over western Greece. Natural Hazards and Earth System Sciences [Internet]. 2014;14(9):2409 - 2421. WebsiteAbstract
Tornadoes have been reported in Greece during the last few decades and recent studies have given evidence that western Greece is an area vulnerable to tornadoes, waterspouts and funnel clouds In this study, the composite means and anomalies of synoptic conditions for tornadic events (tornadoes, waterspouts and funnel clouds) over western Greece are analyzed and discussed. The daily composite means of synoptic conditions were based on the National Centers for Environmental Prediction-National Center for Atmospheric Research (NCEP-NCAR) reanalysis data sets, for the period 12 August 1953 to 31 December 2012. The daily composite anomalies were calculated with respect to 30 years of climatological study (1981-2010) of the synoptic conditions. The analysis was carried out in terms of seasonal and monthly variability of composite means and anomalies of synoptic conditions for specific isobaric levels of 500, 700, 850, 925 hPa and the sea level pressure (SLP). In addition, an analysis and discussion about the dynamic lifted index from NCEP-NCAR reanalysis data sets is presented. The daily composite mean analysis of 500 hPa revealed a trough line across the northern Adriatic Sea and central Italy, associated with a SW upper-air stream over western Greece. The maximum composite anomalies were depicted at the isobaric level of 500 hPa during autumn, spring and summer, against winter when the anomaly appeared at 925 hPa isobaric level. In addition, 48% of tornado events during the autumn season occurred in pre-frontal weather conditions (cold fronts) and 27% developed after the passage of the cold front. Furthermore, the main difference in synoptic patterns between tornado and waterspout days along western Greece during the autumn season is the maximum daily composite anomaly over the Gulf of Taranto. © Author(s) 2014. CC Attribution 3.0 License.
Alexopoulos JD, Dilalos S, Poulos SE, Ghionis G, Mavroulis S. Application of geoelectrical techniques in the investigation of a coastal sand dune field. In: Near Surface Geoscience 2014 - 20th European Meeting of Environmental and Engineering Geophysics. ; 2014. Website
Alexopoulos JD, Dilalos S, Poulos S, Ghionis G, Mavroulis S. Application of geoelectrical techniques in the investigation of a coastal sand dune field. In: 20th European Meeting of Environmental and Engineering Geophysics. Vol. Tu_PA2_01. Athens, Greece; 2014. pp. 5. Publisher's Version
Anastopoulou I, Eliopoulos C, Valakos ED, Manolis SK. Application of Purkait's triangle method on a skeletal population from southern Europe. Forensic Sci Int. 2014;245:203.e1-4.Abstract
The existence of sexual dimorphism in individual elements of the human skeleton allows sex determination and significantly enhances the identification of fragmentary skeletal material. Traditionally, the pelvis and the skull are used for an accurate sex determination. Sometimes they are not available and alternative methods have to be used. The aim of this work is to study the sexual dimorphism of the proximal portion of the posterior femur by analyzing the biometric data of the Purkait's triangle. The studied sample comprises 203 individuals (112 males and 91 females) from the Modern Human Skeletal Reference Collection (The Athens Collection) of the Department of Animal & Human Physiology (National & Kapodistrian University of Athens). The biometric data were analyzed by Discriminant Analysis and equations were generated for sex determination, which gave an overall correct classification of 78.3%. For the right and the left femur the percentages of correct classification were 77.8% and 75.9% respectively. These accuracy rates were compared to those of an Indian population and were found to be lower (86.5% for males and 86.3% for females). The study of sexual dimorphism (SD) in Greek, Indian, European-American and African-American populations gave interesting results. The AB diameter in the Greek sample shows the lowest degree of SD while the AC diameter shows the highest. In the other three population samples, the BC diameter shows the highest degree of SD. We assume that the femur anatomy of the Greeks is the major cause that the Purkait method does not give high rates of correct classification. It is therefore advisable that practitioners exercise caution when using this method on skeletal material from Greece, especially in forensic contexts.
Ntountaniotis D, Kellici T, Tzakos A, Kolokotroni P, Tselios T, Becker-Baldus J, Glaubitz C, Lin S, Makriyannis A, Mavromoustakos T. The application of solid-state NMR spectroscopy to study candesartan cilexetil (TCV-116) membrane interactions. Comparative study with the AT1R antagonist drug olmesartan. Biochimica et Biophysica Acta - Biomembranes [Internet]. 2014;1838(10):2439 - 2450. Website
Protogerou AD, Papaioannou TG, Vlachopoulos C. Arterial stiffness mapping: A better navigation to ithaca?. Journal of the American College of Cardiology [Internet]. 2014;63(17):1748 - 1750. Website
Nastos PT, Paliatsos AG, Koukouletsos KV, Larissi IK, Moustris KP. Artificial neural networks modeling for forecasting the maximum daily total precipitation at Athens, Greece. Atmospheric Research [Internet]. 2014;144:141 - 150. WebsiteAbstract
Extreme daily precipitation events are involved in significant environmental damages, even in life loss, because of causing adverse impacts, such as flash floods, in urban and sometimes in rural areas. Thus, long-term forecast of such events is of great importance for the preparation of local authorities in order to confront and mitigate the adverse consequences. The objective of this study is to estimate the possibility of forecasting the maximum daily precipitation for the next coming year. For this reason, appropriate prognostic models, such as Artificial Neural Networks (ANNs) were developed and applied. The data used for the analysis concern annual maximum daily precipitation totals, which have been recorded at the National Observatory of Athens (NOA), during the long term period 1891-2009. To evaluate the potential of daily extreme precipitation forecast by the applied ANNs, a different period for validation was considered than the one used for the ANNs training. Thus, the datasets of the period 1891-1980 were used as training datasets, while the datasets of the period 1981-2009 as validation datasets. Appropriate statistical indices, such as the coefficient of determination (R2), the index of agreement (IA), the Root Mean Square Error (RMSE) and the Mean Bias Error (MBE), were applied to test the reliability of the models. The findings of the analysis showed that, a quite satisfactory relationship (R2=0.482, IA=0.817, RMSE=16.4mm and MBE=+5.2mm) appears between the forecasted and the respective observed maximum daily precipitation totals one year ahead. The developed ANN seems to overestimate the maximum daily precipitation totals appeared in 1988 while underestimate the maximum in 1999, which could be attributed to the relatively low frequency of occurrence of these extreme events within GAA having impact on the optimum training of ANN. © 2013 Elsevier B.V.
Price D, Rasp G, Papadopoulos NG, Scadding G, Bousquet J. Assessing allergic rhinitis symptom control:results from a digital servey conducted during EAACI 2013. Allergy. 2014;69:96.
Bleta A, Nastos PT, Matzarakis A. Assessment of bioclimatic conditions on Crete Island, Greece. Regional Environmental Change [Internet]. 2014;14(5):1967 - 1981. WebsiteAbstract
The objective of this study was to assess and analyze the human bioclimatic conditions of Crete Island, by applying two human thermal indices: physiological equivalent temperature (PET), derived from the Munich Energy-balance Model for Individuals human energy balance model, and Universal Thermal Climate Index (UTCI), based on the Fiala multi-node model of human thermoregulation. Human bioclimatic studies provide a framework for considering the effects of climatic conditions on human beings and highlighting the social/economic factors that mitigate or amplify the consequences of environmental changes. In order to estimate the thermal effect of the environment on the human body, it has been considered that the total effects of all thermal components, not only of individual parameters, should be taken into account. The climatic data (air temperature, relative humidity, cloudiness, wind speed) used in this study were acquired from the archives of the Hellenic National Meteorological Service, regarding ten meteorological stations in Crete Island. These data, covering the 30-year period 1975–2004, were used for the calculation of PET and UTCI in order to assess thermo-physiological stress levels. The findings of this analysis, such as bioclimatic diagrams, temporal and spatial distributions of PET and UTCI as well as trends and variability, will help stake holders to understand and interpret the island’s current bioclimate, in order to make any necessary adaptations and become more resilient to the foreseen climate change. © 2013, Springer-Verlag Berlin Heidelberg.
Dimou Α, Vassilakis E, Antoniou Β, Evelpidou Ν. An assessment of the coastal erosion at Marathon, east Attica (Greece). 10th Congress of the Hellenic Geographical Society [Internet]. 2014:1579-1587. pdf
Monioudi IN, Karditsa A, Chatzipavlis A, Alexandrakis G, Andreadis OP, Velegrakis AF, Poulos SE, Ghionis G, Petrakis S, Sifnioti D, et al. {Assessment of vulnerability of the eastern Cretan beaches (Greece) to sea level rise}. Regional Environmental Change [Internet]. 2014. Website
Monioudi IN, Karditsa A, Chatzipavlis A, Alexandrakis G, Andreadis OP, Velegrakis AF, Poulos SE, Ghionis G, Petrakis S, Sifnioti D, et al. Assessment of vulnerability of the eastern Cretan beaches (Greece) to sea level rise. Regional Environmental Change [Internet]. 2014. Website
Janse JJ, Wong GWK, Potts J, Ogorodova LM, Fedorova OS, Mahesh PA, Sakellariou A, Papadopoulos NG, Knulst AG, Versteeg SA, et al. The association between foodborne and orofecal pathogens and allergic sensitization-Europrevall study. Pediatric Allergy and Immunology. 2014;25:250-256.
Pentheroudakis G, Kotoula V, Kouvatseas G, Charalambous E, Dionysopoulos D, Zagouri F, Koutras A, Papazisis K, Pectasides D, Samantas E, et al. Association of VEGF-A splice variant mRNA expression with outcome in bevacizumab-treated patients with metastatic breast cancer. Clinical Breast Cancer [Internet]. 2014;14(5):330 - 338. WebsiteAbstract
We studied tissue mRNA levels of VEGF-Axxxa angiogenic versus VEGF-Axxxb anti-angiogenic isoforms by means of specially designed PCR assays in two parallel cohorts of metastatic breast cancer patients, one treated with taxane (Cohort A) and one treated with taxaneDbevacizumab (Cohort B). Tissue mRNA expression of angiogenic VEGF-Axxxa isoforms was retrospectively associated with adverse prognosis in the absence of bevacizumab and with favorable outcome when bevacizumab was administered. Background: The prognostic utility of vascular endothelial growth factor A (VEGF-A) splice variants in patients with advanced breast cancer treated with bevacizumab has not been studied. Patients and Methods: A total of 111 patients with metastatic breast cancer treated with weekly docetaxel or ixabepilone without bevacizumab (cohort A) and 100 treated with weekly paclitaxel and bevacizumab (cohort B) were studied. Formalin-fixed tumors were macrodissected for reverse transcription quantitative polymerase chain reaction relative quantification of VEGF-A165, -189, and -206 isoforms spliced at exon 8 proximal splice site (VEGF-Axxxa) and at exon 8 distal splice site (VEGF-Axxxb). Results: For high VEGF-Axxxa, the hazard ratios (HRs) for progression were 1.08 (P = .71) in non-bevacizumab-treated patients (cohort A) and 0.66 (P = .22) in bevacizumab-treated patients (cohort B), and the HRs for death were 1.45 (P = .13) and 0.50 (P = .049), respectively. The interaction of VEGF-Axxxa with bevacizumab administration was significant (P = .011) for overall survival (OS). High tissue VEGF-Axxxb was not prognostic in cohort A but was predictive for bevacizumab benefit in cohort B (HR for progression, 0.57 [P = .04]; HR for death, 0.51 [P = .02]). Exploratory analyses done only in cohort B suggested that abundance of VEGFR1 messenger RNA (mRNA) in peripheral blood and low VEGFR2 mRNA in tissue correlated with poor outcome. In multivariate analysis, high tissue mRNA of angiogenic VEGFAxxxa in the presence of bevacizumab therapy predicted for favorable progression-free survival (HR for progression, 0.39; P = .0227) and OS (HR for death, 0.32; P = .0140). Conclusion: Tissue mRNA expression of angiogenic VEGFAxxxa isoforms was retrospectively associated with adverse prognosis in the absence of bevacizumab and with favorable outcome when bevacizumab was administered in patients with advanced breast cancer. © 2014 Elsevier Inc.
Matsangouras IT, Nastos PT, Pytharoulis I, Migglieta MM. Atmospheric conditions analysis of waterspout events based on thermodynamic environment and sea surface temperature distribution over south Aegean Sea. COMECAP2014–ebook of contributions, edited by: Kanakidou, M., Mihalopoulos, N., and Nastos, P., Proceedings 12th International Conference of Meteorology, Climatology and Physics of the Atmosphere, Greece, Crete University Press ; 2014.
Isaksen ISA, Berntsen TK, Dalsøren SB, Eleftheratos K, Orsolini Y, Rognerud B, Stordal F., Søvde OA, Zerefos CS, Holmes CD. Atmospheric ozone and methane in a changing climate. Atmosphere [Internet]. 2014;5:518-535. Publisher's Version a23_atmosphere_2014.pdf
Madesis I, Dimitriou A, Lagoyannis A, Axiotis M, Mertzimekis TJ, Andrianis M, Benis EP, Harissopulos S, Sulik B, Valastyan I. Atomic Physics with Accelerators: Projectile Electron Spectroscopy. [Internet]. 2014. Website
Kastritis E, Terpos E, Dimopoulos MA. Author's reply. Expert opinion on pharmacotherapy [Internet]. 2014;15(2):300. Website
Schwartz SH, Caprara GV, Vecchione M, Bain P, Bianchi G, Caprara MG, Cieciuch J, Lönnqvist J-E, Kirmanoglu H, Baslevent C, et al. Basic personal values underlie and give coherence to political values: A cross-national study in 15 countries. Political Behavior. 2014;36(4):889-930.
Mellema JJ, Doornberg JN, Guitton TG, Ring D. Biomechanical studies: science (f)or common sense?. Injury. 2014;45(12):2035-9.Abstract
INTRODUCTION: It is our impression that many biomechanical studies invest substantial resources studying the obvious: that more and larger metal is stronger. The purpose of this study is to evaluate if a subset of biomechanical studies comparing fixation constructs just document common sense. METHODS: Using a web-based survey, 274 orthopaedic surgeons and 81 medical students predicted the results of 11 biomechanical studies comparing fracture fixation constructs (selected based on the authors' sense that the answer was obvious prior to performing the study). Sensitivity, specificity, and accuracy were calculated according to standard formulas. The agreement among the observers was calculated by using a multirater kappa, described by Siegel and Castellan. RESULTS: The accuracy of predicting outcomes was 80% or greater for 10 of 11 studies. Accuracy was not influenced by level of experience (i.e., time in practice and medical students vs. surgeons). There were substantial differences in accuracy between observers from different regions. The overall categorical rating of inter-observer reliability according to Landis and Koch was moderate (κ=0.55; standard error (SE)=0.01). CONCLUSION: The results of a subset of biomechanical studies comparing fracture fixation constructs can be predicted prior to doing the study. As these studies are time and resource intensive, one criterion for proceeding with a biomechanical study should be that the answer is not simply a matter of common sense.
Book review of Peters M. A., Besley, T. &amp; Araya, D. (eds). <em>The New Development</em> <em>Paradigm: Education, Knowledge Economy and Digital Futures</em>. New York: Peter Lang.
Mitsikopoulou B. Book review of Peters M. A., Besley, T. & Araya, D. (eds). The New Development Paradigm: Education, Knowledge Economy and Digital Futures. New York: Peter Lang. Teachers College Record [Internet]. 2014;116(5). Publisher's Version the_new_development_paradigm_book_review.pdf
Almpanis E, Papanikolaou N, Stefanou N. Breakdown of the linear acousto-optic interaction regime in phoxonic cavities. Optics Express. 2014;22(26):31595-31607.Abstract
The limits of validity of the linear photoelastic model are investigated in a one-dimensional dual photonic-phononic cavity, formed by alternating layers of a chalcogenide glass and a polymer homogeneous and isotropic material, which supports both optical and acoustic resonant modes localized in the same region. It is shown that the linear-response regime breaks down when either the acoustic excitation increases or the first-order acousto-optic interaction coupling element vanishes by symmetry, giving rise to the manifestation of multiphonon absorption and emission processes by a photon. Our results provide a consistent interpretation of different aspects of the underlying physics relating to nonlinear acousto-optic interactions that can occur in such cavities.
Tselekounis M, Varoutas D, Martakos D. A CDS approach to induce facilities-based competition over NGA networks. Telecommunications Policy. 2014;38:311–331.
Dalamaga M, Sotiropoulos GP, Vrioni G, Tsakris A. Cedecea: An "unknown" pathogen in the family of Enterobacteriaceae - Its clinical importance, detection and identification methods. Acta Microbiologica Hellenica [Internet]. 2014;59(1):17 - 28. Website
Apostolidis, N.a BKSPGC a N. Changes in the lipid profile of elite basketball and soccer players after a match. Research in Sports Medicine [Internet]. 2014;22:100-110. WebsiteAbstract
The lipid profile of elite basketball and soccer athletes was evaluated and compared with that of inactive individuals. Total cholesterol (T-C), low and high density lipoprotein cholesterol (LDL-C and HDL-C), and triglyceride (TG) concentration were measured in the morning and after a soccer or a basketball match. All parameters of lipid profile measured at a fasted and resting state, except HDL-C, were lower in the athletes compared with the controls (p < 0.01). The soccer match resulted in a greater decrease in TG (78.3 ± 6.7 to 70.7 ± 6.3, p < 0.01), T-C (179.3 ± 10.7 to 171.6 ± 9.6, p < 0.01), LDL-C (110.9 ± 8.9 to 103.5 ± 7.5, p < 0.01) compared with the basketball match that resulted only in a decrease in LDL-C (126.8 ± 9.5 to 117.3 ± 9.1, p < 0.01) and an increase in HDL-C that was similar to that observed after the soccer match (9-12%). These findings support the beneficial effects of basketball and soccer on cardiovascular health. © 2013 © Taylor & Francis Group, LLC.
Apostolidis N a, Bogdanis GC a, Kostopoulos N a, Souglis A a, Papadopoulos C b. Changes in the lipid profile of elite basketball and soccer players after a match. Research in Sports Medicine [Internet]. 2014;22:100-110. WebsiteAbstract
The lipid profile of elite basketball and soccer athletes was evaluated and compared with that of inactive individuals. Total cholesterol (T-C), low and high density lipoprotein cholesterol (LDL-C and HDL-C), and triglyceride (TG) concentration were measured in the morning and after a soccer or a basketball match. All parameters of lipid profile measured at a fasted and resting state, except HDL-C, were lower in the athletes compared with the controls (p < 0.01). The soccer match resulted in a greater decrease in TG (78.3 ± 6.7 to 70.7 ± 6.3, p < 0.01), T-C (179.3 ± 10.7 to 171.6 ± 9.6, p < 0.01), LDL-C (110.9 ± 8.9 to 103.5 ± 7.5, p < 0.01) compared with the basketball match that resulted only in a decrease in LDL-C (126.8 ± 9.5 to 117.3 ± 9.1, p < 0.01) and an increase in HDL-C that was similar to that observed after the soccer match (9-12%). These findings support the beneficial effects of basketball and soccer on cardiovascular health. © 2013 © Taylor & Francis Group, LLC.
Apostolidis N, Bogdanis GC, Kostopoulos N, Souglis A, Papadopoulos C. Changes in the lipid profile of elite basketball and soccer players after a match. Research in Sports Medicine [Internet]. 2014;22(1):100 - 110. WebsiteAbstract
The lipid profile of elite basketball and soccer athletes was evaluated and compared with that of inactive individuals. Total cholesterol (T-C), low and high density lipoprotein cholesterol (LDL-C and HDL-C), and triglyceride (TG) concentration were measured in the morning and after a soccer or a basketball match. All parameters of lipid profile measured at a fasted and resting state, except HDL-C, were lower in the athletes compared with the controls (p < 0.01). The soccer match resulted in a greater decrease in TG (78.3 ± 6.7 to 70.7 ± 6.3, p < 0.01), T-C (179.3 ± 10.7 to 171.6 ± 9.6, p < 0.01), LDL-C (110.9 ± 8.9 to 103.5 ± 7.5, p < 0.01) compared with the basketball match that resulted only in a decrease in LDL-C (126.8 ± 9.5 to 117.3 ± 9.1, p < 0.01) and an increase in HDL-C that was similar to that observed after the soccer match (9-12%). These findings support the beneficial effects of basketball and soccer on cardiovascular health. © 2013 © Taylor & Francis Group, LLC.
Vavouranakis G. The changing significance of nature within Minoan society. In: Touchais G, Laffineur R, Andreou S, Rougement F, Prokopiou H, Fouache E Physis: Natural environment and human interaction in the Prehistoric Aegean. 14th international Aegean conference, Institut National d’Histoire de l’Art (INHA), University Paris 1 Panthéon-Sorbonne, 11-14 December 2012 (Aegaeum 37). Louvain and Liège: Peeters; 2014. pp. 559-560.
Paraskevopoulou V, Dassenakis M, Botsou F, Teou X, Sakkelari A, Diamantis V, Poulos S, Lazogiannis K, Matiatos J, Sifnioti D, et al. Chemical quality of groundwaters in the deltaic plain of Pinios river: Preliminary results after a year of monitoring. In: Liakopoulos, Kungolos, Christodoulatos, Koutsopsyros 12th International Conference on Protection and Restoration of the Environment . Athens; 2014. pp. 154-161. Publisher's Version
Roumpedaki E, Douladiris N, Papanaki A, Stamogiannou L, Maggina P, Manoussakis E, Vallianatou G, Papadopoulos NG, Xepapadaki P. A child with anaphylactic reaction by egg remedy applied to burn. Pediatr Allergy Immunol. 2014.
Gkotzamanidou M, Sfikakis PP, Kyrtopoulos SA, Bamia C, Dimopoulos MA, Souliotis VL. Chromatin structure, transcriptional activity and DNA repair efficiency affect the outcome of chemotherapy in multiple myeloma. British journal of cancer [Internet]. 2014;111(7):1293 - 1304. WebsiteAbstract
Melphalan is one of the most active chemotherapeutic agents in the treatment of multiple myeloma (MM). However, the mechanism underlying differential patient responses to melphalan therapy is unknown. METHODS :Chromatin structure, transcriptional activity and DNA damage response signals were examined following ex vivo treatment with melphalan of both malignant bone marrow plasma cells (BMPCs) and peripheral blood mononuclear cells (PBMCs) of MM patients, responders (n=57) or non-responders (n=28) to melphalan therapy. PBMCs from healthy controls (n=25) were also included in the study. In both BMPCs and PBMCs, the local chromatin looseness, transcriptional activity and repair efficiency of the transcribed strand (TS) were significantly higher in non-responders than in responders and lowest in healthy controls (all P<0.05). Moreover, we found that melphalan-induced apoptosis inversely correlated with the repair efficiency of the TS, with the duration of the inhibition of mRNA synthesis, phosphorylation of p53 at serine 15 and apoptosis rates being higher in responders than in non-responders (all P<0.001). Our findings provide a mechanistic basis for the link between DNA repair efficiency and response to melphalan therapy. Interestingly, the observation of these phenomena in PBMCs provides a novel approach for the prediction of response to anti-myeloma therapy.
Dalamaga M, Polyzos SA, Karmaniolas K, Chamberland J, Lekka A, Migdalis I, Papadavid E, Dionyssiou-Asteriou A, Mantzoros CS. Circulating fetuin-A in patients with pancreatic cancer: a hospital-based case-control study. Biomarkers. 2014;19(8):660-6.Abstract
CONTEXT: A proteomic analysis has proposed fetuin-A (alpha-2-HS-glycoprotein) as a new potential marker for pancreatic cancer (PC). OBJECTIVE: Circulating fetuin-A levels in patients with PC. METHODS: Serum fetuin-A was measured in 81 cases with PC and 81 matched controls before the initiation of any treatment. RESULTS: Serum fetuin-A was not independently associated with the presence of PC. Although there was a trend with higher fetuin-A levels across PC stages, comparisons of fetuin-A in patients within different PC prognostic stages revealed no differences. CONCLUSIONS: Circulating fetuin-A was similar between patients and controls and was not associated with the disease severity.
Matsangouras IT, Nastos PT, Bluestein HB, Sioutas MV. A climatology of tornadic activity over Greece based on historical records. International Journal of Climatology [Internet]. 2014;34(8):2538 - 2555. WebsiteAbstract
In this study, the climatology of tornadoes, waterspouts and funnel clouds over Greece is presented for the period 1709-2012. The climatology consists of two datasets. An historical dataset (1709-1999) is based on newspaper archives, historical archives, published tornado literature, administrative records and reports of Hellenic National Meteorological Service (HNMS). A recent dataset (2000-2012) is based on newspaper articles, eyewitness reports to the media, HNMS's reports and an open-ended online tornado report database which has been developed and maintained by the Laboratory of Climatology & Atmospheric Environment of the University of Athens. Altogether, 612 Greek tornadic events compose the climatology: 171 tornadoes, 374 waterspouts and 67 funnel clouds. Tornadic events during the past 13years (2000-2012) have occurred all over the Greek territory and there is frequent tornadic occurrence over north Crete and Corfu Island. Tornadoes are more frequent to occur over NW Peloponnesus followed by south parts of Corfu Island. However, waterspouts are more frequent over north Crete followed by Corfu Island. Tornadic monthly variability depicts a maximum during October, followed by September and November. October is the month with the highest tornado frequency, followed by November and July. The highest waterspout frequency month is September followed by October and December. Tornadoes most commonly develop during the warm time of the day, as more than 75% of all cases occur during 08:00-15:00hours UTC with a maximum at 12:00hours UTC. Waterspout frequency of occurrence has two maxima during the day, the first early in the morning (07:00-09:00hours UTC) and the second after the noon time period (14:00-15:00hours UTC). The dominant (27.7% of total cases) intensity of tornadoes in Greece is T4 based on the T-scale during the 300-year period (1709-2012); there have been at least 114 injured and 29 deaths. © 2013 Royal Meteorological Society.
Katodritou E, Terpos E, Symeonidis AS, Pouli A, Kelaidi C, Kyrtsonis M-C, Kotsopoulou M, Delimpasi S, Christoforidou A, Giannakoulas N, et al. Clinical features, outcome, and prognostic factors for survival and evolution to multiple myeloma of solitary plasmacytomas: A report of the Greek myeloma study group in 97 patients. American Journal of Hematology [Internet]. 2014;89(8):803 - 808. WebsiteAbstract
Solitary plasmacytoma (SP) is a rare plasma cell dyscrasia characterized by the presence of bone or extramedullary plasma cell tumors. The treatment of choice is local radiotherapy (R/T)±surgical excision. The role of adjuvant chemotherapy (C/T) or novel agents (NA) is uncertain. Data related to prognostic factors are inconclusive. Herein, we describe the clinical features, survival and prognosis of 97 consecutive patients, 65 with bone SP (SBP), and 32 with extramedullary SP (SEP), diagnosed and treated in 12 Greek Myeloma Centers. Objective response rate (≥PR) and complete response (CR) was 91.8% and 61.9%, respectively, and did not differ between the 2 groups. Overall, 38 patients relapsed or progressed to multiple myeloma (MM). After a median follow-up of 60 months, 5 and 10-year overall survival (OS) probability was 92% and 89% in SEP and 86% and 69% in SBP, respectively (P=0.2). The 5- and 10-year MM-free survival (MMFS) probability was 90% and 70% for patients with SEP vs. 59% and 50% for patients with SBP, respectively (P=0.054). Overall, the 5- and 10-year OS probability, plasmacytoma relapse-free survival (PRFS), progression-free survival and MMFS was 84% and 78%, 72% and 58%, 58% and 43%, and 70% and 59%, respectively. In the multivariate analysis, prolonged PRFS and young age were positive predictors of OS. Achievement of CR was the only positive predictor of PRFS. Immunoparesis was the only negative predictor of progression to MM. The addition of C/T or NA-based treatment increased toxicity without offering any survival advantage over R/T. Am. J. Hematol. 89:803-808, 2014. © 2014 Wiley Periodicals, Inc.
Haahtela T, Burbach GJ, Bachert C, Bindslev-Jensen C, Bonini S, Bousquet J, Bousquet-Rouanet L, Bousquet PJ, Bresciani M, Bruno A, et al. Clinical relevance is associated with allergen-specific wheal size in skin prick testing. Clin Exp Allergy. 2014;44(3):407-16.Abstract
BACKGROUND: Within a large prospective study, the Global Asthma and Allergy European Network (GA(2) LEN) has collected skin prick test (SPT) data throughout Europe to make recommendations for SPT in clinical settings. OBJECTIVE: To improve clinical interpretation of SPT results for inhalant allergens by providing quantitative decision points. METHODS: The GA(2) LEN SPT study with 3068 valid data sets was used to investigate the relationship between SPT results and patient-reported clinical relevance for each of the 18 inhalant allergens as well as SPT wheal size and physician-diagnosed allergy (rhinitis, asthma, atopic dermatitis, food allergy). The effects of age, gender, and geographical area on SPT results were assessed. For each allergen, the wheal size in mm with an 80% positive predictive value (PPV) for being clinically relevant was calculated. RESULTS: Depending on the allergen, from 40% (blatella) to 87-89% (grass, mites) of the positive SPT reactions (wheal size ≥ 3 mm) were associated with patient-reported clinical symptoms when exposed to the respective allergen. The risk of allergic symptoms increased significantly with larger wheal sizes for 17 of the 18 allergens tested. Children with positive SPT reactions had a smaller risk of sensitizations being clinically relevant compared with adults. The 80% PPV varied from 3 to 10 mm depending on the allergen. CONCLUSION: These 'reading keys' for 18 inhalant allergens can help interpret SPT results with respect to their clinical significance. A SPT form with the standard allergens including mm decision points for each allergen is offered for clinical use.
Siahanidou T, Margeli A, Tsirogianni C, Charoni S, Giannaki M, Vavourakis E, Charisiadou A, Papassotiriou I. Clinical value of plasma soluble urokinase-type plasminogen activator receptor levels in term neonates with infection or sepsis: a prospective study. Mediators Inflamm. 2014;2014:375702.Abstract
BACKGROUND: suPAR, the soluble form of the urokinase-type plasminogen activator receptor, has been identified as a biomarker of infection in adults but its properties in neonatal infection are not known. METHODS: Plasma suPAR levels were determined by ELISA in 47 term neonates with infection (19 bacterial and 28 viral) and in 18 healthy neonates as controls. Thirteen out of 47 infected neonates were septic. In all infected neonates, suPAR levels were repeated at 24 hours, 48 hours, 3-5 days, and 7-10 days following admission. RESULTS: Plasma suPAR levels were significantly increased in infected neonates upon admission, whereas they were highest in septic neonates, in comparison with controls (P < 0.001) and correlated positively with serum CRP levels (P = 0.001). At infection subsidence, suPAR concentrations decreased significantly in comparison with baseline (P < 0.001) but remained higher than in controls (P = 0.01). Receiver operating characteristic analysis resulted in significant areas under the curve for detecting either infected or septic neonates, but not for discriminating between bacterial and viral cause of infection. CONCLUSIONS: suPAR is a diagnostic biomarker of infection or sepsis in term neonates; however, it cannot discriminate bacterial from viral infections and also its utility for monitoring the response to treatment is questioned.
Simou E, Papanikolaou D, Lykousis V, Nomikou P, Vassilakis E. Coastal and submarine instabilities distribution in the tectonically active SW margin of the Corinth Rift (Psathopyrgos, Achaia, Greece). In: EGU2014. Vol. 16. Vienna, Austria; 2014. pp. 9780. Poster
Simou E, Papanikolaou D, Lykousis V, Nomikou P, Vassilakis E. Coastal and submarine instabilities distribution in the tectonically active SW margin of the Corinth Rift (Psathopyrgos, Achaia, Greece). EGU2014. 2014;16:9780.
Simou E, Nomikou P, Lykousis V, Papanikolaou D, Vassilakis E. Coastal hazard related to landslide distribution derived from morphotectonic analysis (SW gulf of Corinth, Greece). 10th Congress of the Hellenic Geographical Society. 2014.
Tselekounis M, Orfanou G, Varoutas D. Coexistence of copper and fiber unbundling: Access charges and investment incentives. 2014.
Kamberidou I. Collective Intelligence Rises when Women Participate and the Myth that we can have it All ! [in Greek]. LWB- leading women in business, ICAP Group (www.icap.gr), pp. 126-127. Complementary book/edition in daily newspaper TA NEA, Saturday, December 20, 2014. [article in Greek] http://dir.icap.gr/mailimages/e-books/LWB/index.html Also see: http://www.i. 2014. icap._ta_nea_20.12.2014._kamberidou.pdf
Terpos E, Christoulas D, Kastritis E, Katodritou E, Papatheodorou A, Pouli A, Kyrtsonis M-C, Michalis E, Papanikolaou X, Gkotzamanidou M, et al. The combination of lenalidomide and dexamethasone reduces bone resorption in responding patients with relapsed/refractory multiple myeloma but has no effect on bone formation: Final results on 205 patients of the Greek myeloma study group. American Journal of Hematology [Internet]. 2014;89(1):34 - 40. WebsiteAbstract
The combination of lenalidomide plus dexamethasone (RD) is very effective for patients with relapsed/refractory myeloma. However, the effect of RD on bone metabolism has not been previously evaluated in these patients. To address this issue, we initially performed a retrospective study in 106 consecutive patients with relapsed or refractory myeloma who received RD. We measured the following bone indices on Cycle 1/Day 1 and then on Cycles 3 and 6/Day 28: dickkopf-1 (Dkk-1), sRANKL, osteoprotegerin (OPG), bone resorption markers (C-telopeptide of collagen type-I, CTX and TRACP-5b) and bone formation markers (bone-specific alkaline phosphatase-bALP and osteocalcin). RD produced a reduction of CTX only in responders, with no effect on bone formation. To validate these results, we then evaluated prospectively 99 patients who received either RD (n=50) or VRD (bortezomib + RD, n=49). RD reduced CTX, mainly in responders but showed no effect on bone formation, confirming the result of the retrospective study. However, the addition of bortezomib to RD (VRD arm) reduced Dkk-1, sRANKL/OPG, and CTX, while it increased bALP and OC after six cycles of therapy. These changes were irrespective of treatment response, which was similar between treatment arms. No skeletal-related events were observed in the VRD arm while two, nonresponding patients treated with RD developed a vertebral fracture. We conclude that RD reduces bone resorption only in responding patients with relapsed/refractory myeloma but has no effect on bone formation. Combination with bortezomib, which enhances bone formation, seems to be preferred for the management of myeloma patients with osteolytic disease. © 2013 Wiley Periodicals, Inc.
Stratta P, Airoldi A, Battista M, Guglielmetti G, Radin E, Izzo C, Merlotti G, Quaglia M, Kastritis E, Terpos E, et al. Comment on: Think to prevent before than to treat renal impairment in multiple myeloma: Do not forget tubular damage mimicking Fanconi syndrome. Expert Opinion on Pharmacotherapy [Internet]. 2014;15(2):299 - 300. Website
Mitsi E. Commodifying Antiquity in Mary Nisbet’s Journey to the Ottoman Empire. Travel, Discovery, Transformation. 2014;1:45.
Passioti M, Maggina P, Megremis S, Papadopoulos NG. The Common Cold: Potential for Future Prevention or Cure. Current Allergy Asthma Reports. 2014;14.
Nikolaou VS, Chytas D, Babis GC. Common controversies in total knee replacement surgery: Current evidence. World J Orthop. 2014;5(4):460-8.Abstract
Total knee replacement (TKR) is a widely used operation that has radically improved the quality of life of millions of people during the last few decades. However, some technical details, concerning the surgical procedure and the rehabilitation following total knee arthroplasty, are still a matter of a strong debate. In this review of the literature, we have included the best evidence available of the last decade, in an effort to shed light on some of the most controversial subjects related to TKR surgery. Posterior-stabilized or cruciate-retaining prosthesis? To use a tourniquet during operation or not? Do patients need continuous passive motion for their post-surgery rehabilitation? To resurface patella or not? These are some of the most controversial topics that until now have been persistent dilemmas for the orthopedic surgeon. Results of this systematic review of the literature are highly controversial. These conflicting results are an indication that larger and more well conducted high quality trials are needed in order to gain more secure answers. At the same time, it is becoming apparent that a meticulous operative technique, respecting the soft tissue envelope and knowing the principles of alignment and soft tissue balancing, are some of the parameters that might contribute more to achieving the optimal results for the patients.
Melea PI, Melakopoulos I, Kastritis E, Tesseromatis C, Margaritis V, Dimopoulos MA, Terpos E. Conservative treatment of bisphosphonate-related osteonecrosis of the jaw in multiple myeloma patients. International Journal of Dentistry [Internet]. 2014;2014. WebsiteAbstract
The use of intravenous bisphosphonates (pamidronate or zoledronic acid) is the cornerstone for the management of multiple myeloma-(MM-) related bone disease. However, osteonecrosis of the jaw (ONJ) is a rare, but sometimes difficult to manage, adverse effect of bisphosphonates therapy. A retrospective review of all MM patients who were treated with bisphosphonates in our department, from 2003 to 2013, and developed ONJ was performed. According to inclusion criteria, 38 patients were studied. All these patients were treated as conservatively as possible according to the American Association of Oral and Maxillofacial Surgeons criteria. Patients were managed with observation, oral antibacterial mouth rinse with chlorhexidine, oral antibiotics, pain control with analgesics, nonsurgical sequestrectomy with or without simultaneous administration of antibiotics, or major surgery with or without antibiotics. Healing of the lesions was achieved in 23 (60%) patients who were treated with conservative measures; the median time to healing was 12 months (95% CI: 4-21). The number of bisphosphonates infusions influenced the time to healing: the median time to healing for patients who received <16 infusions was 7 months and for those with >16 infusions was it 14 months P=0.017. We conclude that a primarily nonsurgical approach appears to be a successful management strategy for bisphosphonate-related ONJ. © 2014 Pelagia I. Melea et al.
Anasontzis GE, Kourtoglou E, Mamma D, Villas-Boâs SG, Hatzinikolaou DG, Christakopoulos P. Constitutive homologous expression of phosphoglucomutase and transaldolase increases the metabolic flux of Fusarium oxysporum. Microbial Cell Factories [Internet]. 2014;13:Article 43. Publisher's VersionAbstract
Background: Fusarium oxysporum is among the few filamentous fungi that have been reported of being able to directly ferment biomass to ethanol in a consolidated bioprocess. Understanding its metabolic pathways and their limitations can provide some insights on the genetic modifications required to enhance its growth and subsequent fermentation capability. In this study, we investigated the hypothesis reported previously that phosphoglucomutase and transaldolase are metabolic bottlenecks in the glycolysis and pentose phosphate pathway of the F. oxysporum metabolism. Results: Both enzymes were homologously overexpressed in F. oxysporum F3 using the gpdA promoter of Aspergillus nidulans for constitutive expression. Transformants were screened for their phosphoglucomutase and transaldolase genes expression levels with northern blot. The selected transformant exhibited high mRNA levels for both genes, as well as higher specific activities of the corresponding enzymes, compared to the wild type. It also displayed more than 20 and 15% higher specific growth rate upon aerobic growth on glucose and xylose, respectively, as carbon sources and 30% higher biomass to xylose yield. The determination of the relative intracellular amino and non-amino organic acid concentrations at the end of growth on glucose revealed higher abundance of most determined metabolites between 1.5- and 3-times in the recombinant strain compared to the wild type. Lower abundance of the determined metabolites of the Krebs cycle and an 68-fold more glutamate were observed at the end of the cultivation, when xylose was used as carbon source. Conclusions: Homologous overexpression of phosphoglucomutase and transaldolase in F. oxysporum was shown to enhance the growth characteristics of the strain in both xylose and glucose in aerobic conditions. The intracellular metabolites profile indicated how the changes in the metabolome could have resulted in the observed growth characteristics.
mcf_2014_13_43.pdf
Kenourgios, D. DD. Contagion effects of the Global Financial Crisis in US and European real economy sectors. Panoeconomicus [Internet]. 2014;61:275-288. Website
Bella S. A contrastive study of apologies performed by Greek native speakers and learners of Greek as a foreign language. Pragmatics [Internet]. 2014;24(4):679-713. Publisher's Version
Alexopoulos J. The contribution of the geo-electrical parameters distribution in the investigation of the paleo geographical evolution of the deltaic plain of Pineios river (Thessaly). 10th Congress of the Hellenic Geographical Society. 2014.
Kostić N, Dotsikas Y, Malenović A. Critical review on the analytical methods for the determination of zwitterionic antiepileptic drugs-Vigabatrin, Pregabalin, and Gabapentin - In bulk and formulations. Instrumentation Science and Technology [Internet]. 2014;42(4):486 - 512. Website
Savvatianos S, Konstantinopoulos A, Borga A, J L, Borres M, Manousakis E, NG P. Cross- reactivity between Anacardiaceae (cashew/pistachio) and Rutaceae (orange/lemon) seeds. Allergy. 2014;69:553.
Gil-De-Gómez L, Astudillo AM, Guijas C, Magrioti V, Kokotos G, Balboa MA, Balsinde J. Cytosolic group IVA and calcium-independent group VIA phospholipase A2s act on distinct phospholipid pools in zymosan-stimulated mouse peritoneal macrophages. Journal of Immunology. 2014;192:752-762.Abstract
Phospholipase A2s generate lipid mediators that constitute an important component of the integrated response of macrophages to stimuli of the innate immune response. Because these cells contain multiple phospholipase A2 forms, the challenge is to elucidate the roles that each of these forms plays in regulating normal cellular processes and in disease pathogenesis. A major issue is to precisely determine the phospholipid substrates that these enzymes use for generating lipid mediators. There is compelling evidence that group IVA cytosolic phospholipase A2 (cPLA2α) targets arachidonic acid–containing phospholipids but the role of the other cytosolic enzyme present in macrophages, the Ca2+-independent group VIA phospholipase A2 (iPLA2β) has not been clearly defined. We applied mass spectrometry–based lipid profiling to study the substrate specificities of these two enzymes during inflammatory activation of macrophages with zymosan. Using selective inhibitors, we find that, contrary to cPLA2α, iPLA2β spares arachidonate-containing phospholipids and hydrolyzes only those that do not contain arachidonate. Analyses of the lysophospholipids generated during activation reveal that one of the major species produced, palmitoyl-glycerophosphocholine, is generated by iPLA2β, with minimal or no involvement of cPLA2α. The other major species produced, stearoyl-glycerophosphocholine, is generated primarily by cPLA2α. Collectively, these findings suggest that cPLA2α and iPLA2β act on different phospholipids during zymosan stimulation of macrophages and that iPLA2β shows a hitherto unrecognized preference for choline phospholipids containing palmitic acid at the sn-1 position that could be exploited for the design of selective inhibitors of this enzyme with therapeutic potential.
Dead archaeologists, buried gods: archaeology as an agent of modernity in Greece. In: Tziovas D Re-imagining the Past. Antiquity and Modern Greek Culture. Oxford: Oxford University Press; 2014. pp. 147-164.
Kambas A, Venetsanou F. The Democritos Movement Screening Tool for preschool children (DEMOST-PRE< sup>©): Development and factorial validity. Research in developmental disabilities. 2014;35(7):1528-1533.
Zegaer BH, Ioannidis A, Babis GC, Ioannidou V, Kossyvakis A, Bersimis S, Papaparaskevas J, Petinaki E, Pliatsika P, Chatzipanagiotou S. Detection of Bacteria Bearing Resistant Biofilm Forms, by Using the Universal and Specific PCR is Still Unhelpful in the Diagnosis of Periprosthetic Joint Infections. Front Med (Lausanne). 2014;1:30.Abstract
Intraoperative conventional bacteriological cultures were compared with different polymerase chain reaction (PCR) methods in patients with total joint arthroplasties. The isolated bacteria were investigated for biofilm formation, and the biofilm forming strains, in their planktonic and biofilm forms, were further tested for their antimicrobial resistance against several clinically important antimicrobials. Forty four bone and joint samples were included and classified as infected or non-infected according to standard criteria for periprosthetic hip and knee infections. For the bacteriological diagnosis, conventional culture, two types of universal PCR and species specific PCR for three selected pathogens (Staphylococcus aureus, Staphylococcus epidermidis, and Pseudomonas aeruginosa) were applied. Biofilm formation determination was performed by the tissue culture plate method. Antimicrobial susceptibility of the planktonic bacteria was performed by the minimal inhibitory concentration determination and, of the biofilm forms, by the minimal inhibitory concentration for bacterial regrowth from the biofilm. Twenty samples were culture positive, with S. epidermidis, S. aureus, or P. aeruginosa. All PCR methods were very ineffective in detecting only one pathogen. All isolates were biofilm positive and their biofilm forms, were highly resistant. In this study, compared to PCR, culture remains the "gold standard." The biofilm formation by the causative bacteria and the concomitant manifold increased antimicrobial resistance may explain the clinical failure of treatment in some cases and should be considered in the future for therapeutic planning.
Deutsche Romantik. (Karakassi K, Lindinger S, Mark M). Peter Lang ; 2014.
Developing the ability to refuse: a cross-sectional study of Greek FL refusals
Bella S. Developing the ability to refuse: a cross-sectional study of Greek FL refusals. Journal of Pragmatics [Internet]. 2014;61:35-62. Publisher's Version
Karakassi K. Die Leiden des jungen Leandros. In: Mike M, Tsirimokou L, Naoum I, Tiktopoulou K Neugriechische Literatur und Kritik seit der Aufklärung und bis heute. Athen: Sokolis -Kouledaki; 2014. pp. 177 - 188.
Gardener SL, Rainey-Smith SR, Barnes MB, Sohrabi HR, Weinborn M, Lim YY, Harrington K, Taddei K, Gu Y, Rembach A, et al. Dietary patterns and cognitive decline in an Australian study of ageing. Mol Psychiatry. 2014.Abstract
The aim of this paper was to investigate the association of three well-recognised dietary patterns with cognitive change over a 3-year period. Five hundred and twenty-seven healthy participants from the Australian Imaging, Biomarkers and Lifestyle study of ageing completed the Cancer Council of Victoria food frequency questionnaire at baseline and underwent a comprehensive neuropsychological assessment at baseline, 18 and 36 months follow-up. Individual neuropsychological test scores were used to construct composite scores for six cognitive domains and a global cognitive score. Based on self-reported consumption, scores for three dietary patterns, (1) Australian-style Mediterranean diet (AusMeDi), (2) western diet and (3) prudent diet were generated for each individual. Linear mixed model analyses were conducted to examine the relationship between diet scores and cognitive change in each cognitive domain and for the global score. Higher baseline adherence to the AusMeDi was associated with better performance in the executive function cognitive domain after 36 months in apolipoprotein E (APOE) ɛ4 allele carriers (P<0.01). Higher baseline western diet adherence was associated with greater cognitive decline after 36 months in the visuospatial cognitive domain in APOE ɛ4 allele non-carriers (P<0.01). All other results were not significant. Our findings in this well-characterised Australian cohort indicate that adherence to a healthy diet is important to reduce risk for cognitive decline, with the converse being true for the western diet. Executive function and visuospatial functioning appear to be particularly susceptible to the influence of diet.Molecular Psychiatry advance online publication, 29 July 2014; doi:10.1038/mp.2014.79.
Zachariadou L, Stathi A, Tassios PT, Pangalis A, Legakis NJ, Papaparaskevas J. Differences in the epidemiology between paediatric and adult invasive Streptococcus pyogenes infections. Epidemiol Infect. 2014;142(3):512-9.Abstract
In order to investigate for possible differences between paediatric and adult invasive Streptococcus pyogenes (iGAS) infections, a total of 142 cases were identified in 17 Greek hospitals during 2003-2007, of which 96 were children and 46 adults. Bacteraemia, soft tissue infections, streptococcal toxic shock syndrome (STSS), and necrotizing fasciitis were the main clinical presentations (67·6%, 45·1%, 13·4%, and 12·0% of cases, respectively). Bacteraemia and lymphadenitis were significantly more frequent in children (P=0·019 and 0·021, respectively), whereas STSS was more frequent in adults (P=0·017). The main predisposing factors in children were varicella and streptococcal pharyngotonsillitis (25% and 19·8%, respectively), as opposed to malignancy, intravenous drug abuse and diabetes mellitus in adults (19·6%, 15·2% and 10·9%, respectively). Of the two dominant emm-types, 1 and 12 (28·2% and 8·5%, respectively), the proportion of emm-type 12 remained stable during the study period, whereas emm-type 1 rates fluctuated considerably. Strains of emm-type 1 from children were associated with erythromycin susceptibility, STSS and intensive-care-unit admission, whereas emm-type 12 isolates from adults were associated with erythromycin and clindamycin resistance. Finally, specific emm-types were detected exclusively in adults or in children. In conclusion, several clinical and epidemiological differences were detected, that could prove useful in designing age-focused strategies for prevention and treatment of iGAS infections.
Petrović, J. PGĆBPLZSMJA. Different extraction methodologies and their influence on the bioactivity of the wild edible mushroom Laetiporus sulphureus (Bull.) Murrill. Food and Function [Internet]. 2014;5:2948-2960. Website
Digital enrichment of EFL textbooks
Mitsikopoulou B. Digital enrichment of EFL textbooks. In: Psaltou Joycey A, Agathopoulou E, Mattheoudakis M Cross-curricular approaches to language education. Newcastle: Cambridge Scholars Publishing; 2014. pp. 404-430. 2014_gala_mitsikopoulou.pdf
Tsokos Α, Kotsi Ε, Vassilakis E. Digital processing of high spatial resolution remote sensing data time series in order to observe the temporal displacement of shorelines. In: 6th Panhellenic Conference on Coastal Zone Management and Improvement. Athens; 2014. pdf
Salvilla SA, Dubois AEJ, Flokstra-de Blok BMJ, Panesar SS, Worth A, Patel S, Muraro A, Halken S, Hoffmann-Sommergruber K, DunnGalvin A, et al. Disease-specific health-related quality of life instruments for IgE-mediated food allergy. Allergy. 2014;69(7):834-44.Abstract
This is one of seven interlinked systematic reviews undertaken on behalf of the European Academy of Allergy and Clinical Immunology as part of their Guidelines for Food Allergy and Anaphylaxis, which focuses on instruments developed for IgE-mediated food allergy. Disease-specific questionnaires are significantly more sensitive than generic ones in measuring the response to interventions or future treatments, as well as estimating the general burden of food allergy. The aim of this systematic review was therefore to identify which disease-specific, validated instruments can be employed to enable assessment of the impact of, and investigations and interventions for, IgE-mediated food allergy on health-related quality of life (HRQL). Using a sensitive search strategy, we searched seven electronic bibliographic databases to identify disease-specific quality of life (QOL) tools relating to IgE-mediated food allergy. From the 17 eligible studies, we identified seven disease-specific HRQL instruments, which were then subjected to detailed quality appraisal. This revealed that these instruments have undergone formal development and validation processes, and have robust psychometric properties, and therefore provide a robust means of establishing the impact of food allergy on QOL. Suitable instruments are now available for use in children, adolescents, parents/caregivers, and adults. Further work must continue to develop a clinical minimal important difference for food allergy and for making these instruments available in a wider range of European languages.
Roulia M, Mavromoustakos T, Vassiliadis AA, Mali G. Distinctive spectral and microscopic features for characterizing the three-dimensional local aluminosilicate structure of perlites. Journal of Physical Chemistry C [Internet]. 2014;118(46):26649 - 26658. Website
Karavasilis V, Kosmidis P, Syrigos KN, Mavropoulou P, Dimopoulos MA, Kotoula V, Pectasides D, Boukovinas I, Klouvas G, Kalogera-Fountzila A, et al. Docetaxel and intermittent erlotinib in patients with metastatic non-small cell lung cancer; a phase II study from the hellenic cooperative oncology group. Anticancer Research [Internet]. 2014;34(10):5649 - 5655. WebsiteAbstract
Aim: To determine the more effective dosing sequence of intermittent erlotinib and docetaxel for treating chemotherapy-naive patients with advanced Non-Small Cell Lung Cancer (NSCLC). Patients and Methods: Patients were randomized to receive daily erlotinib for 12 consecutive days prior to docetaxel (Arm A) or after docetaxel (Arm B). Progression-free survival (PFS) was the primary end-point; secondary end-points were overall survival (OS) and objective response rate (ORR). Results: Fifty eligible patients received a total of 226 treatment cycles (median: 3). Median PFS and OS were 3.6 months and 10.5 months, respectively (differences were not statistically significant between the two arms). Neutropenia grade 3 and 4 occurred in 15 patients, while two patients developed grade 3 diarrhea. There were two treatment-related deaths (pulmonary embolism and non-neutropenic sepsis). Conclusion: Intermittent administration of erlotinib does not appear to improve the clinical outcome of single-agent docetaxel chemotherapy in unselected patients with NSCLC in the first-line setting. © 2014, International Institute of Anticancer Research. All rights reserved.
Arealis G, Galanopoulos I, Nikolaou VS, Lacon A, Ashwood N, Kitsis C. Does the CT improve inter- and intra-observer agreement for the AO, Fernandez and Universal classification systems for distal radius fractures?. Injury. 2014;45(10):1579-84.Abstract
INTRODUCTION: Distal radius fractures are very common upper limb injuries irrespective of the patient's age. The aim of our study is to evaluate the reliability of the three systems that are often used for their classification (AO - Arbeitsgemeinschaft für Osteosynthesefragen/Association for the Study of Internal Fixation, Fernandez and Universal) and to assess the need for computed tomography (CT) scan to improve inter- and intra-observer agreement. MATERIALS AND METHODS: Five orthopaedic surgeons and two hand surgeons classified radiographs and CT scans of 26 patients using the Fernandez, AO and Universal systems. All data were recorded using MS Excel and Kappa statistics were performed to determine inter- and intra-observer agreement and to evaluate the role of CT scan. RESULTS: Fair-to-moderate inter-observer agreement was noted with the use of X-rays for all classification systems. Intra-observer reproducibility did not improve with the addition of CT scans, especially for the senior hand surgeons. CONCLUSIONS: The agreement rates observed in the present study show that currently there is no classification system that is fully reproducible. Adequate experience is required for the assessment and treatment of these injuries. CT scan should be requested only by experienced hand surgeons in order to help guide treatment, as it does not significantly improve inter- and intra-observer agreement for all classification systems.
Fountzilas G, Dafni U, Papadimitriou C, Timotheadou E, Gogas H, Eleftheraki AG, Xanthakis I, Christodoulou C, Koutras A, Papandreou CN, et al. Dose-dense sequential adjuvant chemotherapy followed, as indicated, by trastuzumab for one year in patients with early breast cancer: First report at 5-year median follow-up of a Hellenic Cooperative Oncology Group randomized phase III trial. BMC Cancer [Internet]. 2014;14(1). WebsiteAbstract
Background: Dose-dense sequential chemotherapy including anthracyclines and taxanes has been established in the adjuvant setting of high-risk operable breast cancer. However, the preferable taxane and optimal schedule of administration in a dose-dense regimen have not been defined yet.Methods: From July 2005 to November 2008, 1001 patients (990 eligible) were randomized to receive, every 2 weeks, 3 cycles of epirubicin 110 mg/m2 followed by 3 cycles of paclitaxel 200 mg/m2 followed by 3 cycles of intensified CMF (Arm A; 333 patients), or 3 cycles of epirubicin followed by 3 cycles of CMF, as in Arm A, followed 3 weeks later by 9 weekly cycles of docetaxel 35 mg/m2 (Arm B; 331), or 9 weekly cycles of paclitaxel 80 mg/m2 (Arm C; 326). Trastuzumab was administered for one year to HER2-positive patients post-radiation.Results: At a median follow-up of 60.5 months, the 3-year disease-free survival (DFS) rate was 86%, 90% and 88%, for Arms A, B and C, respectively, while the 3-year overall survival (OS) rate was 96% in all arms. No differences were found in DFS or OS between the combined B and C Arms versus Arm A (DFS: HR = 0.81, 95% CI: 0.59-1.11, P = 0.20; OS: HR = 0.84, 95% CI: 0.55-1.30, P = 0.43). Among the 255 patients who received trastuzumab, 189 patients (74%) completed 1 year of treatment uneventfully. In all arms, the most frequently reported severe adverse events were neutropenia (30% vs. 27% vs. 26%) and leucopenia (12% vs. 13% vs. 12%), while febrile neutropenia occurred in fifty-one patients (6% vs. 4% vs. 5%). Patients in Arm A experienced more often severe pain (P = 0.002), neurological complications (P = 0.004) and allergic reactions (P = 0.004), while patients in Arm B suffered more often from severe skin reactions (P = 0.020).Conclusions: No significant differences in survival between the regimens were found in the present phase III trial. Taxane scheduling influenced the type of severe toxicities. HER2-positive patients demonstrated comparable 3-year DFS and OS rates with those reported in other similar studies.Trial registration: Australian New Zealand Clinical Trials Registry ACTRN12610000151033. © 2014 Fountzilas et al.; licensee BioMed Central Ltd.
van der Geer, A.A.E., Lyras, G.A., VAN DEN HOEK OSTENDE, L.W., DE VOS, J., DRINIA H. A dwarf elephant and a rock mouse on Naxos (Cyclades, Greece) with a revision of the palaeozoogeography of the Cycladic Islands (Greece) during the Pleistocene in relation to adjacent areas. Palaeogeography, Palaeoclimatology, Palaeoecology [Internet]. 2014;404:133-144. Publisher's Version
Katavoutas G a, Flocas HA a, Matzarakis A b. Dynamic modeling of human thermal comfort after the transition from an indoor to an outdoor hot environment. International Journal of Biometeorology [Internet]. 2014. WebsiteAbstract
Thermal comfort under non-steady-state conditions primarily deals with rapid environmental transients and significant alterations of the meteorological conditions, activity, or clothing pattern within the time scale of some minutes. In such cases, thermal history plays an important role in respect to time, and thus, a dynamic approach is appropriate. The present study aims to investigate the dynamic thermal adaptation process of a human individual, after his transition from a typical indoor climate to an outdoor hot environment. Three scenarios of thermal transients have been considered for a range of hot outdoor environmental conditions, employing the dynamic two-node IMEM model. The differences among them concern the radiation field, the activity level, and the body position. The temporal pattern of body temperatures as well as the range of skin wettedness and of water loss have been investigated and compared among the scenarios and the environmental conditions considered. The structure and the temporal course of human energy fluxes as well as the identification of the contribution of body temperatures to energy fluxes have also been studied and compared. In general, the simulation results indicate that the response of a person, coming from the same neutral indoor climate, varies depending on the scenario followed by the individual while being outdoors. The combination of radiation field (shade or not) with the kind of activity (sitting or walking) and the outdoor conditions differentiates significantly the thermal state of the human body. Therefore, 75 % of the skin wettedness values do not exceed the thermal comfort limit at rest for a sitting individual under the shade. This percentage decreases dramatically, less than 25 %, under direct solar radiation and exceeds 75 % for a walking person under direct solar radiation. © 2014 ISB.
Muraro A, Werfel T, Hoffmann-Sommergruber K, Roberts G, Beyer K, Bindslev-Jensen C, Cardona V, Dubois A, duToit G, Eigenmann P, et al. EAACI food allergy and anaphylaxis guidelines: diagnosis and management of food allergy. Allergy. 2014;69(8):1008-25.Abstract
Food allergy can result in considerable morbidity, impact negatively on quality of life, and prove costly in terms of medical care. These guidelines have been prepared by the European Academy of Allergy and Clinical Immunology's (EAACI) Guidelines for Food Allergy and Anaphylaxis Group, building on previous EAACI position papers on adverse reaction to foods and three recent systematic reviews on the epidemiology, diagnosis, and management of food allergy, and provide evidence-based recommendations for the diagnosis and management of food allergy. While the primary audience is allergists, this document is relevant for all other healthcare professionals, including primary care physicians, and pediatric and adult specialists, dieticians, pharmacists and paramedics. Our current understanding of the manifestations of food allergy, the role of diagnostic tests, and the effective management of patients of all ages with food allergy is presented. The acute management of non-life-threatening reactions is covered in these guidelines, but for guidance on the emergency management of anaphylaxis, readers are referred to the related EAACI Anaphylaxis Guidelines.
Muraro A, Halken S, Arshad SH, Beyer K, Dubois AEJ, duToit G, Eigenmann PA, Grimshaw KEC, Hoest A, Lack G, et al. EAACI food allergy and anaphylaxis guidelines. Primary prevention of food allergy. Allergy. 2014;69(5):590-601.Abstract
Food allergy can have significant effects on morbidity and quality of life and can be costly in terms of medical visits and treatments. There is therefore considerable interest in generating efficient approaches that may reduce the risk of developing food allergy. This guideline has been prepared by the European Academy of Allergy and Clinical Immunology's (EAACI) Taskforce on Prevention and is part of the EAACI Guidelines for Food Allergy and Anaphylaxis. It aims to provide evidence-based recommendations for primary prevention of food allergy. A wide range of antenatal, perinatal, neonatal, and childhood strategies were identified and their effectiveness assessed and synthesized in a systematic review. Based on this evidence, families can be provided with evidence-based advice about preventing food allergy, particularly for infants at high risk for development of allergic disease. The advice for all mothers includes a normal diet without restrictions during pregnancy and lactation. For all infants, exclusive breastfeeding is recommended for at least first 4-6 months of life. If breastfeeding is insufficient or not possible, infants at high-risk can be recommended a hypoallergenic formula with a documented preventive effect for the first 4 months. There is no need to avoid introducing complementary foods beyond 4 months, and currently, the evidence does not justify recommendations about either withholding or encouraging exposure to potentially allergenic foods after 4 months once weaning has commenced, irrespective of atopic heredity. There is no evidence to support the use of prebiotics or probiotics for food allergy prevention.
Muraro A, Hoffmann-Sommergruber K, Holzhauser T, Poulsen LK, Gowland MH, Akdis CA, Mills ENC, Papadopoulos N, Roberts G, Schnadt S, et al. EAACI Food Allergy and Anaphylaxis Guidelines. Protecting consumers with food allergies: understanding food consumption, meeting regulations and identifying unmet needs. Allergy. 2014;69(11):1464-72.Abstract
Individuals suffering from IgE-mediated food allergy usually have to practise life-long food allergen avoidance. This document aims to provide an overview of recent evidence-based recommendations for allergen risk assessment and management in the food industry and discusses unmet needs and expectations of the food allergic consumer in that context. There is a general duty of care on the food industry and obligations in European Union legislation to reduce and manage the presence of allergens alongside other food hazards. Current evidence enables quantification of allergen reference doses used to set-up reliable food safety management plans for some foods. However, further work is required to include a wider variety of foods and to understand the impact of the food matrix as well as additional factors which affect the progression and severity of symptoms as a function of dose. Major concerns have been raised by patients, carers and patient groups about the use of precautionary 'may contain' labelling to address the issue of unintended presence of allergens; these therefore need to be reconsidered. New and improved allergen detection methods should be evaluated for their application in food production. There is an urgent requirement for effective communication between healthcare professionals, patient organizations, food industry representatives and regulators to develop a better approach to protecting consumers with food allergies.
CORNÉE, J.-J., MÜNCH, PH., Melinte-Dobrinescu, M., Ben Moussa, A., Quillévéré, F., Drinia, H., Azdimousa, A., TOUHAMI, A.O., Merzeraud, G., Fauquette, S., et al. The early Pliocene reflooding in the Western Mediterranean: new insights from the rias of the Internal Rif, Morocco. CR Geoscience [Internet]. 2014;346: 90-98. Publisher's Version
Kamberidou I. The East in the Eyes of Western Women travellers of the 18th and 19th centuries: solidarity and understanding the East. Proceedings of The East in The Eyes of The West International Conference of the Faculty of Arts, Kuwait University. 2014. themesconditions_of_the_conference-2013.pdf the_east_in_the_eyes_of_the_west._faculty_of_arts._kuwait_university_2013.pdf
Venetsanou F, Donti O, Koutsouba M. The effect of a music/ movement program on preschooler’s motor rhythmic ability. European Psychomotricity Journal. 2014;6(1):60-73.
Tsimaris P, Deligeoroglou E, Athanasopoulos N, Economou E, Stamatelopoulos K, Rizos D, Papamichael C, Lambrinoudaki I, Mastorakos G, Creatsas G. The effect of hormone therapy on biochemical and ultrasound parameters associated with atherosclerosis in 46,XY DSD individuals with female phenotype. Gynecological Endocrinology. 2014;30(10):721 - 725.Abstract
© 2014 Informa UK Ltd. All rights reserved. The aim of this study was to evaluate the effect of hormone therapy (HT) in the endothelial function of 46,XY disorders of sexual development (DSD) patients with female phenotype. Biochemical and ultrasound measurements were performed in 20 patients at initiation of oral 2mg 17β-estradiol/1mg norethisterone acetate, and after 6 months of therapy. Lipid profile, including total cholesterol (TC), LDL, HDL, triglycerides (TG) and Atherogenic Index of Plasma (AIP), as well as levels of VE-Cadherin, E-Selectin, Thrombomodulin and vWf were determined. Ultrasonographic examinations included evaluation of flow-mediated dilatation (FMD) and measurement of Carotid and Femoral Intima Media Thickness (IMT). HT raised HDL (35.4mg/dl versus 40.1mg/dl, p=0.019) while lowering TG (166mg/dl versus 109mg/dl, p=0.026) and AIP (0.24 versus 0.04, p=0.007). No changes were noted in TC and LDL (215.7mg/dl versus 192.25mg/dl and 87.46mg/dl versus 76.35mg/dl, respectively). There was significant reduction of VE-Cadherin (4.05ng/ml versus 2.20ng/ml, p=0.002) and E-selectin (73.98ng/ml versus 56.73ng/ml, p=0.004). No change was observed in Thrombomodulin and vWf (11.76ng/ml versus 13.90ng/ml and 80.75% versus 79.55%, respectively). FMD improved significantly (5.4% versus 8.15%, p=0.003), while only carotid bulb IMT decreased significantly (0.65mm versus 0.60mm, p=0.018). Overall, HT was found to improve biochemical and ultrasound markers of endothelial function in 46,XY DSD patients with female phenotype.
Koumarianou A, Christodoulou M-I, Patapis P, Papadopoulos I, Liakata E, Giagini A, Stavropoulou A, Poulakaki N, Tountas N, Xiros N, et al. The effect of metronomic versus standard chemotherapy on the regulatory to effector T-cell equilibrium in cancer patients. Experimental Hematology and Oncology. 2014;3.
Yu A, Giannone T, Scheffler P, Doonan RJ, Egiziano G, Gomez Y-H, Papaioannou TG, Daskalopoulou SS. The effect of oral Contraceptive pills and the natural menstrual cYCLe on arterial stiffness and hemodynamICs (CYCLIC). Journal of Hypertension [Internet]. 2014;32(1):100 - 107. Website
Vrachatis D, Papaioannou TG, Konstantopoulou A, Nasothimiou EG, Millasseau S, Blacher J, Safar ME, Sfikakis PP, Stergiou GS, Protogerou AD. Effect of supine versus sitting position on noninvasive assessment of aortic pressure waveform: A randomized cross-over study. Journal of Human Hypertension [Internet]. 2014;28(4):236 - 241. Website
Zelenitsas, C.a KMBTV b M a. The effects of a concurrent strength and endurance training on endurance and muscle strength in soccer players. Cultura, Ciencia y Deporte [Internet]. 2014;9:S78. Website
Zelenitsas C a, Kalapotharakos V b, Mitrotasios M a, Bogdanis G a, Tokmakidis S b. The effects of a concurrent strength and endurance training on endurance and muscle strength in soccer players. Cultura, Ciencia y Deporte [Internet]. 2014;9:S78. Website
Donti, O. TBCGC. Effects of baseline levels of flexibility and vertical jump ability on performance following different volumes of static stretching and potentiating exercises in elite gymnasts. Journal of Sports Science and Medicine [Internet]. 2014;13:105-113. WebsiteAbstract
This study examined the effects of baseline flexibility and vertical jump ability on straight leg raise range of motion (ROM) and counter-movement jump performance (CMJ) following different volumes of stretching and potentiating exercises. ROM and CMJ were measured after two different warm-up protocols involving static stretching and potentiating exercises. Three groups of elite athletes (10 male, 14 female artistic gymnasts and 10 female rhythmic gymnasts) varying greatly in ROM and CMJ, performed two warm-up routines. One warm-up included short (15 s) static stretching followed by 5 tuck jumps, while the other included long static stretching (30 s) followed by 3x5 tuck jumps. ROM and CMJ were measured before, during and for 12 min after the two warm-up routines. Three-way ANOVA showed large differences between the three groups in baseline ROM and CMJ performance. A type of warm-up x time interaction was found for both ROM (p = 0.031) and CMJ (p = 0.016). However, all athletes, irrespective of group, responded in a similar fashion to the different warm-up protocols for both ROM and CMJ, as indicated from the lack of significant interactions for group (condition x group, time x group or condition x time x group). In the short warm-up protocol, ROM was not affected by stretching, while in the long warm-up protocol ROM increased by 5.9% ± 0.7% (p = 0.001) after stretching. Similarly, CMJ remained unchanged after the short warm-up protocol, but increased by 4.6 ± 0.9% (p = 0.012) 4 min after the long warmup protocol, despite the increased ROM. It is concluded that the initial levels of flexibility and CMJ performance do not alter the responses of elite gymnasts to warm-up protocols differing in stretching and potentiating exercise volumes. Furthermore, 3 sets of 5 tuck jumps result in a relatively large increase in CMJ performance despite an increase in flexibility in these highly-trained athletes. © Journal of Sports Science and Medicine.
Donti O, Tsolakis C, Bogdanis GC. Effects of baseline levels of flexibility and vertical jump ability on performance following different volumes of static stretching and potentiating exercises in elite gymnasts. Journal of Sports Science and Medicine [Internet]. 2014;13:105-113. WebsiteAbstract
This study examined the effects of baseline flexibility and vertical jump ability on straight leg raise range of motion (ROM) and counter-movement jump performance (CMJ) following different volumes of stretching and potentiating exercises. ROM and CMJ were measured after two different warm-up protocols involving static stretching and potentiating exercises. Three groups of elite athletes (10 male, 14 female artistic gymnasts and 10 female rhythmic gymnasts) varying greatly in ROM and CMJ, performed two warm-up routines. One warm-up included short (15 s) static stretching followed by 5 tuck jumps, while the other included long static stretching (30 s) followed by 3x5 tuck jumps. ROM and CMJ were measured before, during and for 12 min after the two warm-up routines. Three-way ANOVA showed large differences between the three groups in baseline ROM and CMJ performance. A type of warm-up x time interaction was found for both ROM (p = 0.031) and CMJ (p = 0.016). However, all athletes, irrespective of group, responded in a similar fashion to the different warm-up protocols for both ROM and CMJ, as indicated from the lack of significant interactions for group (condition x group, time x group or condition x time x group). In the short warm-up protocol, ROM was not affected by stretching, while in the long warm-up protocol ROM increased by 5.9% ± 0.7% (p = 0.001) after stretching. Similarly, CMJ remained unchanged after the short warm-up protocol, but increased by 4.6 ± 0.9% (p = 0.012) 4 min after the long warmup protocol, despite the increased ROM. It is concluded that the initial levels of flexibility and CMJ performance do not alter the responses of elite gymnasts to warm-up protocols differing in stretching and potentiating exercise volumes. Furthermore, 3 sets of 5 tuck jumps result in a relatively large increase in CMJ performance despite an increase in flexibility in these highly-trained athletes. © Journal of Sports Science and Medicine.
Batzina A, Dalla C, Papadopoulou-Daifoti Z, Karakatsouli N. Effects of environmental enrichment on growth, aggressive behaviour and brain monoamines of gilthead seabream Sparus aurata reared under different social conditions. Comp Biochem Physiol A Mol Integr Physiol. 2014;169:25-32.Abstract
The presence of blue or red-brown substrate on the tank bottom has been previously reported as an efficient means of environmental enrichment for gilthead seabream. The present study aimed to investigate whether this enrichment is still beneficial when gilthead seabream is reared under different social conditions (i.e. a lower 4.9 kg m(-3) and a higher 9.7 kg m(-3) density). Water exchange was adjusted according to fish biomass to exclude density effects on water quality. In the enriched tanks single-colour glass gravel was used as substrate (blue and red-brown substrate, or BS and RBS respectively), while control tanks had no gravel. Growth, aggressive behaviour and size distribution results indicated that the lower density created a less favourable social environment. In both densities studied, BS enhanced growth, suppressed aggression and reduced brain serotonergic activity. In the condition of intense social interactions (i.e. the lower density) BS also reduced brain dopaminergic activity. These results along with the negative correlations observed between brain monoamines and fish body mass, indicated that substrate and density effects are socially-induced. However, there may be several biotic and/or abiotic factors interfering with substrate effects that should be investigated before the practical use of a substrate in land-based intensive aquaculture.
Kouvelioti R, Vagenas G, Langley-Evans S. The effects of exercise and diet on weight loss maintenance in overweight and obese adults: a systematic review. The Journal of Sport Medicine and Physical Fitness [Internet]. 2014;54(4):456-474. Publisher's VersionAbstract
Overweight and obesity are widespread nutritional disorders. Their treatment aims at effective weight loss (WL) and weight loss maintenance (WLM). Previous systematic reviews show weight regain, after recommended exercise and diet combined. However, certain experimental and methodological inconsistencies in the original studies and in these reviews left space for a substantial revisit of this problem. This study aimed at systematically re-reviewing the effectiveness of exercise combined with diet on WLM in overweight and obese adults. Literature was searched through Embase and Sport Discus (up to 2008), and PubMed (Medline) and ISI Web of science (up to 2012). 14 randomized clinical trials (RCT) were retained, their quality was assessed by the Jadad scale, and detailed methodological and statistical characteristics were evaluated. Overall estimations showed a WL of 11.1 kg (about 13%) after an average of about 4 months from baseline, a WLM of 5.8 kg (about 52%) and a weight regain of 5.1 kg after an average period of about 21 months. WL was successful but almost half of it (about 48%) was regained, which agrees with previous findings. The Jadad score showed very good to excellent quality for all 14 studies. However, further assessment revealed serious weakness such as high average dropout (>20%), not estimating experimental power or not using a control group in more than half of the studies, possible lack of adherence and variability in demographic traits. Future studies may focus on improving these limitations for more accurate results in this crucial research field.
Bogdanis GC, Tsoukos A, Veligekas P, Tsolakis C, Terzis G. Effects of muscle action type with equal impulse of conditioning activity on postactivation potentiation. Journal of Strength and Conditioning Research [Internet]. 2014;28:2521-2528. WebsiteAbstract
This study investigated the effects of muscle action type during conditioning activity (half-squat) on subsequent vertical jump performance. Fourteen track and field athletes (relative half-squat of 2.3 ± 0.3 times their body weight) completed 4 main trials in a randomized and counterbalanced order 5-7 days apart: (a) concentric (CON) halfsquats: 7.5 ± 1.2 repetitions against 90% of 1 repetition maximum (1RM), (b) eccentric (ECC) half-squats: 9.3 ± 1.5 repetitions against 70% of 1RM, and (c) 3 sets of 3-second maximal isometric (ISO) half-squats, (d) a control (CTRL) trial, where subjects rested for 10 minutes. The number of repetitions in CON and ECC was adjusted so that the impulse of the vertical ground reaction force was similar to ISO. Countermovement vertical jump (CMJ) performance was evaluated for 21 minutes after each main trial. Countermovement vertical jump performance in ISO was higher than CTRL from the second to the 10th minute of recovery, whereas CMJ performance in ECC was higher than CTRL from the sixth and 10th minute of recovery. Analysis of the peak individual responses revealed an increase in CMJ performance compared with baseline only in ISO (3.06 1.2%; p = 0.045), whereas no significant increases were observed in ECC and CON. Peak CMJ performance for all subjects in ISO and ECC was achieved within 2-10 minutes after the conditioning muscle actions. Isometric were more effective than CON and ECC muscle actions in increasing explosive leg performance when the impulse of the ground reaction force of the conditioning exercise was equated. © 2014 National Strength and Conditioning Association.
Bogdanis, G.C. TVTTAPC. Effects of muscle action type with equal impulse of conditioning activity on postactivation potentiation. Journal of Strength and Conditioning Research [Internet]. 2014;28:2521-2528. WebsiteAbstract
This study investigated the effects of muscle action type during conditioning activity (half-squat) on subsequent vertical jump performance. Fourteen track and field athletes (relative half-squat of 2.3 ± 0.3 times their body weight) completed 4 main trials in a randomized and counterbalanced order 5-7 days apart: (a) concentric (CON) halfsquats: 7.5 ± 1.2 repetitions against 90% of 1 repetition maximum (1RM), (b) eccentric (ECC) half-squats: 9.3 ± 1.5 repetitions against 70% of 1RM, and (c) 3 sets of 3-second maximal isometric (ISO) half-squats, (d) a control (CTRL) trial, where subjects rested for 10 minutes. The number of repetitions in CON and ECC was adjusted so that the impulse of the vertical ground reaction force was similar to ISO. Countermovement vertical jump (CMJ) performance was evaluated for 21 minutes after each main trial. Countermovement vertical jump performance in ISO was higher than CTRL from the second to the 10th minute of recovery, whereas CMJ performance in ECC was higher than CTRL from the sixth and 10th minute of recovery. Analysis of the peak individual responses revealed an increase in CMJ performance compared with baseline only in ISO (3.06 1.2%; p = 0.045), whereas no significant increases were observed in ECC and CON. Peak CMJ performance for all subjects in ISO and ECC was achieved within 2-10 minutes after the conditioning muscle actions. Isometric were more effective than CON and ECC muscle actions in increasing explosive leg performance when the impulse of the ground reaction force of the conditioning exercise was equated. © 2014 National Strength and Conditioning Association.
Dimopoulos MA, Swern AS, Li JS, Hussein M, Weiss L, Nagarwala Y, Baz R. Efficacy and safety of long-term treatment with lenalidomide and dexamethasone in patients with relapsed/refractory multiple myeloma. Blood Cancer Journal [Internet]. 2014;4(11). WebsiteAbstract
Data from two randomized pivotal, phase 3 trials evaluating the combination of lenalidomide and dexamethasone in relapsed/refractory multiple myeloma (RRMM) were pooled to characterize the subset of patients who achieved long-term benefit of therapy (progression-free survival ≥3 years). Patients with long-term benefit of therapy (n = 45) had a median duration of treatment of 48.1 months and a response rate of 100%. Humoral improvement (uninvolved immunoglobulin A) was more common in patients with long-term benefit of therapy (79% vs 55%; P = 0.002). Significant predictors of long-term benefit of therapy in multivariate analysis were age < 65 years (P = 0.03), β2-microglobulin <2.5 mg/l (P = 0.002) and fewer prior therapies (P = 0.002). The exposureadjusted incidence rate (EAIR) of grade 3-4 neutropenia was lower in patients with long-term benefit of therapy (13.9 vs 38.2 per 100 patient-years). The EAIR for invasive second primary malignancy was the same in patients with long-term benefit of therapy and other patients (1.7 per 100 patient-years). These findings indicate that patients with RRMM can experience long-term benefit with lenalidomide and dexamethasone treatment with manageable side effects. © 2014 Macmillan Publishers Limited All rights reserved.
Ntountaniotis D, Agelis G, Resvani A, Halabalaki M, Liapakis G, Spyridaki K, Golic Grdadolnik S, Merzel F, Kostidis S, Potamitis C, et al. An efficient synthetic method and theoretical calculations of olmesartan methyl ether: Study of biological function of AT1 antagonism. Combinatorial Chemistry and High Throughput Screening [Internet]. 2014;17(8):642 - 662. Website
Kritikou V. Cecilia Valdés o La Loma del Ángel de Cirilo Villaverde: Historia y Literatura. In: Estudios y Homenajes Hispanoamericanos II. Vol. 2. 1st ed. Madrid: Ediciones del Orto; 2014. pp. 83-86. Publisher's Version kritikou.cecilia_valdes.historia_y_literatura.pdf
Kritikou V. Complementos sociales. Realismo y Naturalismo en Hispanoamérica. 1st ed. Madrid: Ediciones del Orto; 2014 pp. 96.
ATHANASSOPOULOU EKAVI. Strategic Relations Between the US and Turkey: Sleeping with a Tiger. First. London: Routledge; 2014 pp. 209. Publisher's VersionAbstract
Taking the period from the end of the 1970s to the end of the 1990s, this book critically examines the evolution of the strategic relationship between the US and Turkey during this period, with a particular focus on the Middle Eastern context. Strategic Relations Between the US and Turkey employs interviews with US, Turkish and Israeli officials and archival research in order to offer an alternative reading of the realities that shaped bilateral co-operation through multi-level analysis. The unraveling of these realities enlightens the reader about the past course of events but also aids the understanding of the dynamics of the relationship today. Essential reading for students and scholars of U.S. and Turkish foreign policy, this study of co-operation between a super-power and a relatively weak state in the international system will also be of use to those interested in International Relations, Diplomatic History and World Politics more broadly.
Γογγάκη Κ, Καλογεράκος Ι. Φιλοσοφία και Αθλητισμός. Πρακτικά Β’ Φιλοσοφικού Συμποσίου, 16 Μαΐου 2014. 2014.Abstract
  • (2014). Κωνσταντίνα Γογγάκη – Ιωάννης Γ. Καλογεράκος (επιμ.). Φιλοσοφία και Αθλητισμός. Πρακτικά Β’ Φιλοσοφικού Συμποσίου, Αθήνα, 16 Μαΐου 2014. Έκδοση Σπουδαστηρίου Φιλοσοφίας του Αθλητισμού του ΤΕΦΑΑ Εθνικού και Καποδιστριακού Παν/μίου Αθηνών, εκδόσεις Παπαηλιού, Αθήνα.
2014._filosofia_kai_athlitismos_praktika_2oy_filosofikoy_symposioy.pdf 2014._2o_filosofiko_symposio._filosofia_athlitismos._eisigiseis.pdf
Moustris KP, Nastos PT, Bartzokas A, Larissi IK, Zacharia PT, Paliatsos AG. Energy consumption based on heating/cooling degree days within the urban environment of Athens, Greece. Theoretical and Applied Climatology [Internet]. 2014;122:517-529. Website
Rapti S-M, Kontos CK, Papadopoulos IN, Scorilas A. Enhanced miR-182 transcription is a predictor of poor overall survival in colorectal adenocarcinoma patients. Clinical Chemistry and Laboratory Medicine. 2014;52:1217-1227.
Batzina A, Dalla C, Tsopelakos A, Papadopoulou-Daifoti Z, Karakatsouli N. Environmental enrichment induces changes in brain monoamine levels in gilthead seabream Sparus aurata. Physiol Behav. 2014;130:85-90.Abstract
It is generally accepted that environmental enrichment enhances the performance and improves welfare of animals kept in captivity. Similar results have been obtained for fish. It has been previously reported that the presence of Blue or Red-Brown Substrate (BS and RBS respectively) on tank bottom resulted in growth enhancement and suppression of aggressive behavior of gilthead seabream Sparus aurata compared to Green Substrate (GS) and tanks without modifications (Control-C). In an attempt to identify the underlying mechanisms, in the present study the effects of this environmental enrichment on brain monoamine neurotransmitters and fatty acids of gilthead seabream were evaluated. BS and RBS fish had lower serotonergic activity (5-HIAA/5-HT), resulting mainly from lower 5-hydroxyindoleacetic acid (5-HIAA) levels. BS fish also had lower serotonin levels compared to all other treatments. Brain noradrenaline (NA) levels did not show significant differences between substrate treatments and control. Brain dopamine (DA) levels were lowest in BS and RBS fish, higher in GS fish and highest in C fish. No differences were observed for dopamine metabolites or dopaminergic activity. Moreover, brain NA was negatively correlated with body weight in BS fish and positively correlated in RBS and C fish. A positive correlation was also observed for brain DA with body weight in RBS fish. No differences were observed for brain fatty acids. Present results support the hypothesis that the beneficial effects of the presence of BS and RBS are related to altered social interactions and indicate the establishment of a less stressful social organization in enriched-reared fish groups.
Armeni E, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A. Erratum: Arterial stiffness is increased in asymptomatic non-diabetic postmenopausal women with a PCOS phenotype (Journal of Hypertension (2013) 31 (1998-2004)). Journal of Hypertension. 2014;32(3):702 - 702.
Alexopoulos JD, Dilalos S, Tsatsaris A, Mavroulis S. ERT and VLF measurements contributing to the extended revelation of the ancient town of Trapezous, (Megalopolis, Peloponnesus, Greece). In: 20th European Meeting of Environmental and Engineering Geophysics. Vol. Mo_PA2_05. Athens, Greece; 2014. pp. 5. Publisher's Version
Herbert A, Cruickshank JK, Laurent S, Boutouyrie P, Shimada K, Kario K, Miyashita H, Eguchi K, Kohara K, Tabara Y, et al. Establishing reference values for central blood pressure and its amplification in a general healthy population and according to cardiovascular risk factors. European Heart Journal [Internet]. 2014;35(44):3122 - 3133. Website
Engelhardt M, Terpos E, Kleber M, Gay F, Wäsch R, Morgan G, Cavo M, van de Donk N, Beilhack A, Bruno B, et al. European myeloma network recommendations on the evaluation and treatment of newly diagnosed patients with multiple myeloma. Haematologica [Internet]. 2014;99(2):232 - 242. WebsiteAbstract
Multiple myeloma management has undergone profound changes in the past thanks to advances in our understanding of the disease biology and improvements in treatment and supportive care approaches. This article presents recommendations of the European Myeloma Network for newly diagnosed patients based on the GRADE system for level of evidence. All patients with symptomatic disease should undergo risk stratification to classify patients for International Staging System stage (level of evidence: 1A) and for cytogenetically defined high- versus standard-risk groups (2B). Novel-agent-based induction and up-front autologous stem cell transplantation in medically fit patients remains the standard of care (1A). Induction therapy should include a triple combination of bortezomib, with either adriamycin or thalidomide and dexamethasone (1A), or with cyclophosphamide and dexamethasone (2B). Currently, allogeneic stem cell transplantation may be considered for young patients with high-risk disease and preferably in the context of a clinical trial (2B). Thalidomide (1B) or lenalidomide (1A) maintenance increases progression-free survival and possibly overall survival (2B). Bortezomib-based regimens are a valuable consolidation option, especially for patients who failed excellent response after autologous stem cell transplantation (2A). Bortezomib-melphalan-prednisone or melphalan-prednisone-thalidomide are the standards of care for transplant-ineligible patients (1A). Melphalan-prednisone-lenalidomide with lenalidomide maintenance increases progression-free survival, but overall survival data are needed. New data from the phase III study (MM-020/IFM 07-01) of lenalidomide-low-dose dexamethasone reached its primary end point of a statistically significant improvement in progression-free survival as compared to melphalan-prednisone-thalidomide and provides further evidence for the efficacy of lenalidomide-low-dose dexamethasone in transplant-ineligible patients (2B). © 2013 Ferrata Storti Foundation.
Ludwig H, Sonneveld P, Davies F, Bladé J, Boccadoro M, Cavo M, Morgan G, De La Rubia J, Delforge M, Dimopoulos M, et al. European perspective on multiple myeloma treatment strategies in 2014. Oncologist [Internet]. 2014;19(8):829 - 844. WebsiteAbstract
The treatment of multiple myeloma has undergone significant changes and has resulted in the achievement of molecular remissions, the prolongation of remission duration, and extended survival becoming realistic goals, with a cure being possible in a small but growing number of patients. In addition, nowadays it is possible to categorize patients more precisely into different risk groups, thus allowing the evaluation of therapies in different settings and enabling a better comparison of results across trials. Here, we review the evidence from clinical studies, which forms the basis for our recommendations for the management of patients with myeloma. Treatment approaches depend on "fitness," with chronological age still being an important discriminator for selecting therapy. In younger, fit patients, a short three drug-based induction treatment followed by autologous stem cell transplantation (ASCT) remains the preferred option. Consolidation and maintenance therapy are attractive strategies not yet approved by the European Medicines Agency, and a decision regarding post-ASCT therapy should only be made after detailed discussion of the pros and cons with the individual patient. Two- and three-drug combinations are recommended for patients not eligible for transplantation. Treatment should be administered for at least nine cycles, although different durations of initial therapy have only rarely been compared so far. Comorbidity and frailty should be thoroughly assessed in elderly patients, and treatment must be adapted to individual needs, carefully selecting appropriate drugs and doses. A substantial number of new drugs and novel drug classes in early clinical development have shown promising activity. Their introduction into clinical practice will most likely further improve treatment results. © AlphaMed Press.
Zerva A, Savvides AL, Katsifas EA, Karagouni AD, Hatzinikolaou DG. Evaluation of Paecilomyces variotii potential in bioethanol production from lignocellulose through consolidated bioprocessing. Bioresource Technology [Internet]. 2014;162:294-299. Publisher's VersionAbstract
The ascomycete Paecillomyces variotii was evaluated for the first time as a candidate species for the production of bioethanol from lignocellulose through consolidated bioprocessing (CBP) approaches. The examined strain (ATHUM 8891) revealed all the necessary phenotypic characteristics required for 2nd generation biofuel production. The fungus is able to efficiently ferment glucose and xylose to ethanol, with yields close to the theoretical maximum. Nitrogen supplementation greatly affected ethanol production with nitrate-nitrogen presenting the best results. Notably, ethanol yield on xylose fermentation was higher than that of glucose, while in co-fermentation of glucose–xylose mixtures no distinguished diauxic behavior was observed. Furthermore, the fungus seems to possess the necessary enzyme factory for the degradation of lignocellulosic biomass, as it was able to grow and produce ethanol on common agro-industrial derivatives. Overall, the results of our study indicate that P. variotii is a new and possibly powerful candidate for CBP applications.
Triantaphyllou MV, Gogou A, Bouloubassi I, Dimiza M, Kouli K, Rousakis G, Kotthoff U, Emeis K-C, Papanikolaou M, Athanasiou M, et al. Evidence for a warm and humid Mid-Holocene episode in the Aegean and northern Levantine Seas (Greece, NE Mediterranean). Regional Environmental Change [Internet]. 2014;14(5):1697 - 1712. Publisher's VersionAbstract
Marine and terrestrial biological and biogeochemical proxies in three sediment cores from North and SE Aegean and northern Levantine Seas record continuous warm and humid conditions between 5.5 and 4.0 ka BP related to the establishment of relatively stratified conditions in the upper water column. These conditions may have resulted from the concordant albeit weak Mid-Holocene South Asian monsoon forcing, combined with lighter Etesian winds. During this interval, sea surface temperatures fluctuate in the Aegean Sea, although exhibiting a strong positive shift at*4.8 ka BP. The warm and humid climatic conditions triggered upper water column stratification and enhancement of the deep chlorophyll maximum (DCM), leading to dysoxic conditions and the deposition of a sapropel-like layer, but only in the SE Aegean site. In contrast to the shallow water SE Aegean, the deeper North Aegean and the northern Levantine sites, although experiencing stratification in the upper parts of the water column, did not achieve bottom-water dysoxia. Thus, a top–bottom mechanism of stratification–DCM development accompanied by fast transport and burial of organic matter is a likely explanation for the preservation of productivity signal in the shallow sites of the SE Aegean and establishment of sapropelic conditions during the warm and humid Mid-Holocene. The termination of the Mid-Holocene warm and humid phase coincides with the ‘‘4.2 ka’’ climate event. Our data exhibit an N–S time transgressive aridification gradient around the Aegean Sea, most probably associated with the reorganization of the general atmospheric circulation during the Mid-Holocene.
Triantaphyllou MV, Gogou A, Bouloubassi I, Dimiza M, Kouli K, Rousakis G, Kotthoff U, Emeis K-C, Papanikolaou M, Athanasiou M, et al. Evidence for a warm and humid Mid-Holocene episode in the Aegean and northern Levantine Seas (Greece, NE Mediterranean). Regional Environmental Change [Internet]. 2014;14(5):1697 - 1712. Publisher's VersionAbstract
Marine and terrestrial biological and biogeochemical proxies in three sediment cores from North and SE Aegean and northern Levantine Seas record continuous warm and humid conditions between 5.5 and 4.0 ka BP related to the establishment of relatively stratified conditions in the upper water column. These conditions may have resulted from the concordant albeit weak Mid-Holocene South Asian monsoon forcing, combined with lighter Etesian winds. During this interval, sea surface temperatures fluctuate in the Aegean Sea, although exhibiting a strong positive shift at*4.8 ka BP. The warm and humid climatic conditions triggered upper water column stratification and enhancement of the deep chlorophyll maximum (DCM), leading to dysoxic conditions and the deposition of a sapropel-like layer, but only in the SE Aegean site. In contrast to the shallow water SE Aegean, the deeper North Aegean and the northern Levantine sites, although experiencing stratification in the upper parts of the water column, did not achieve bottom-water dysoxia. Thus, a top–bottom mechanism of stratification–DCM development accompanied by fast transport and burial of organic matter is a likely explanation for the preservation of productivity signal in the shallow sites of the SE Aegean and establishment of sapropelic conditions during the warm and humid Mid-Holocene. The termination of the Mid-Holocene warm and humid phase coincides with the ‘‘4.2 ka’’ climate event. Our data exhibit an N–S time transgressive aridification gradient around the Aegean Sea, most probably associated with the reorganization of the general atmospheric circulation during the Mid-Holocene.
Zerefos CS, Tourpali K, Zanis P, Eleftheratos K, Repapis C, Goodman A, Wuebbles D, Isaksen ISA, Luterbacher J. Evidence for an earlier greenhouse cooling effect in the stratosphere before 1980 over the Northern Hemisphere. Atmos. Chem. Phys. [Internet]. 2014;14:7705–7720. Publisher's Version a24_acp_2014.pdf
Arabatzis T. Experiment. In: M. Curd and S. Psillos (eds), The Routledge Companion to Philosophy of Science. 2nd ed. London: Routledge; 2014. pp. 191-202. Publisher's Version
Dimopoulos MA, Leleu X, Palumbo A, Moreau P, Delforge M, Cavo M, Ludwig H, Morgan GJ, Davies FE, Sonneveld P, et al. Expert panel consensus statement on the optimal use of pomalidomide in relapsed and refractory multiple myeloma. Leukemia [Internet]. 2014;28(8):1573 - 1585. WebsiteAbstract
In this report, a panel of European myeloma experts discuss the role of pomalidomide in the treatment of relapsed and refractory multiple myeloma (RRMM). Based on the available evidence, the combination of pomalidomide and low-dose dexamethasone is a well-tolerated and effective treatment option for patients with RRMM who have exhausted treatment with lenalidomide and bortezomib. The optimal starting dose of pomalidomide is 4 mg given on days 1-21 of each 28-day cycle, whereas dexamethasone is administered at a dose of 40 mg weekly (reduced to 20 mg for patients aged >75 years). The treatment should continue until evidence of disease progression or unacceptable toxicity. Dose-modification schemes have been established for patients who develop neutropenia, thrombocytopaenia and other grade 3-4 adverse events during pomalidomide therapy. Guidance on the prevention and management of infections and venous thromboembolism is provided, based on the available clinical evidence and the experience of panel members. The use of pomalidomide in special populations, such as patients with advanced age, renal impairment or unfavourable cytogenetic features, is also discussed. © 2014 Macmillan Publishers Limited. All rights reserved.
C N, HC K, M D, CA D, I Z. Exploiting the anti-inflammatory properties of olive (Olea europaea) in the sustainable production of functional food and neutraceuticals. Phytochemistry Reviews [Internet]. 2014;13:445-458. Publisher's VersionAbstract
Olive oil is an important lipid source of the Mediterranean diet which has been associated with lower incidence of cardiovascular diseases whereas olive pomace (OP), a natural by-product of olive oil production, has been found to contain micro constituents with antioxidant, antithrombotic and antiatherogenic activities. The evaluation of OP in order to produce sustainable functional food and neutraceuticals has been the subject of research over the last years. All recent data, focusing on the anti-inflammatory properties of olive oil derived from olive (Olea europaea) and OP along with the potential production of sustainable functional food and neutraceuticals, are presented in this review.
Kaskaoutis DG, Rashki A, Houssos EE, Goto D, Nastos PT. Extremely high aerosol loading over Arabian Sea during June 2008: The specific role of the atmospheric dynamics and Sistan dust storms. Atmospheric Environment [Internet]. 2014;94:374 - 384. WebsiteAbstract
This study focuses on analyzing the extreme aerosol loading and the mechanisms, source areas and meteorological conditions that favored the abnormal dust exposure towards Arabian Sea during June 2008. The analysis reveals that the spatial-averaged aerosol optical depth (AOD) over Arabian Sea in June 2008 is 0.5 (78.2%) higher than the 2000-2013 mean June value and is mostly attributed to the enhanced dust activity and several (18) dust storms originated from the Sistan region (Iran-Afghanistan borders). Landsat images show that the marshy lakes in Sistan basin got dried during the second half of June 2008 and the alluvial silt and saline material got easily eroded by the intense Levar winds, which were stronger (>15-20ms-1) than the climatological mean for the month of June. These conditions led to enhanced dust exposure from Sistan that strongly affected the northern and central parts of the Arabian Sea, as forward air-mass trajectories show. The NCEP/NCAR reanalysis reveals an abnormal intensification and spatial expansion of the Indian low pressure system towards northern Arabian Sea in June 2008. This suggests strengthening of the convection over the arid southwest Asia and exposure of significant amount of dust, which can reach further south over Arabian Sea favored by the enhanced cyclonic circulation. MODIS imagery highlighted several dust storms originated from Sistan and affecting Arabian Sea during June 2008, while the SPRINTARS model simulations of increased AOD and dust concentration over Sistan and downwind areas are in agreement with ground-based and satellite observations. © 2014 Elsevier Ltd.
Dimopoulos MA, Palumbo A, Hajek R, Kropff M, Petrucci MT, Lewis P, Millar S, Zhang J, Mei J, Delforge M. Factors that influence health-related quality of life in newly diagnosed patients with multiple myeloma aged ≥ 65 years treated with melphalan, prednisone and lenalidomide followed by lenalidomide maintenance: Results of a randomized trial. Leukemia and Lymphoma [Internet]. 2014;55(7):1489 - 1497. WebsiteAbstract
In the MM-015 trial, melphalan-prednisone-lenalidomide followed by lenalidomide maintenance (MPR-R) significantly prolonged progression-free survival versus melphalan-prednisone (MP) in newly diagnosed patients with multiple myeloma aged ≥ 65 years. Health-related quality of life (HRQoL), a secondary endpoint of MM-015, was also improved with MPR-R. This sub-analysis evaluated the impact of individual predictive factors on HRQoL. Patients completed HRQoL questionnaires at baseline, every third cycle and at progressive disease (PD)/treatment discontinuation. In a mixed-effects model female gender, advanced age and PD negatively affected HRQoL while better treatment responses showed positive effects. Compared to PD, HRQoL during MPR-R treatment was statistically significantly better in two of six preselected domains both of which were also clinically meaningful. HRQoL scores at end of treatment were all either improved or not statistically significantly different versus baseline. In conclusion, continuous treatment with MPR-R, which delays PD, appears to be associated with clinically meaningful improvements in HRQoL. © 2014 Informa UK, Ltd.
Zagouri F, Sergentanis TN, Tsigginou A, Dimitrakakis C, Zografos GC, Dimopoulos M-A, Psaltopoulou T. Female breast cancer in Europe: Statistics, diagnosis and treatment modalities. Journal of Thoracic Disease [Internet]. 2014;6(6):589 - 590. Website
Kamberidou I. "Finally Free to Breathe", Women’s Accounts: women travellers of the 17th, 18th and 19th centuries. Telethrio S.A., Athens [Book in Greek]; 2014.
Kenourgios D. On financial contagion and implied market volatility. International Review of Financial Analysis [Internet]. 2014;34:21-30. Website
Kouvelis VN, Teshima H, Bruce D, Detter C, Tapia R, Han C, Tampakopoulou V-O, Goodwin L, Woyke T, Kyrpides NC, et al. Finished Genome of Zymomonas mobilis subsp. mobilis Strain CP4, an Applied Ethanol Producer. Genome Announc. 2014;2(1).Abstract
Zymomonas mobilis subsp. mobilis is one of the most rigorous ethanol-producing organisms known to date, considered by many to be the prokaryotic alternative to yeast. The two most applied Z. mobilis subsp. mobilis strains, ZM4 and CP4, derive from Recife, Brazil, and have been isolated from sugarcane fermentations. Of these, ZM4 was the first Z. mobilis representative strain to be sequenced and analyzed. Here, we report the finishing of the genome sequence of strain CP4, which is highly similar but not identical to that of ZM4.
Athanasopoulou E, Rieger D, Walter C, Vogel H, Karali A, Hatzaki M, Gerasopoulos E, Vogel B, Giannakopoulos C, Gratsea M, et al. Fire risk, atmospheric chemistry and radiative forcing assessment of wildfires in eastern Mediterranean. Atmospheric Environment [Internet]. 2014;95:113 - 125. Website
Worm M, Moneret-Vautrin A, Scherer K, Lang R, Fernandez-Rivas M, Cardona V, Kowalski ML, Jutel M, Poziomkowska-Gesicka I, Papadopoulos NG, et al. First European data from the network of severe allergic reactions (NORA). Allergy. 2014;69(10):1397-404.Abstract
BACKGROUND: Occurrence, elicitors and treatment of severe allergic reactions are recognized and reported differently between countries. We aimed to collect standardized data throughout Europe on anaphylaxis referred for diagnosis and counselling. METHODS: Tertiary allergy, dermatology and paediatric units in 10 European countries took part in this pilot phase of the first European Anaphylaxis Registry, from June 2011 to March 2014. An online questionnaire was used to collect data on severe allergic reactions based on the medical history and diagnostics. RESULTS: Fifty-nine centres reported 3333 cases of anaphylaxis, with 26.7% below 18 years of age. Allergic reactions were mainly caused by food (children and adults 64.9% and 20.2%, respectively) and insect venom (20.2% and 48.2%) and less often by drugs (4.8% and 22.4%). Most reactions occurred within 30 min of exposure (80.5%); a delay of 4+ hours was mainly seen in drug anaphylaxis (6.7%). Symptom patterns differed by elicitor, with the skin being affected most often (84.1%). A previous, usually milder reaction to the same allergen was reported by 34.2%. The mainstay of first-line treatment by professionals included corticoids (60.4%) and antihistamines (52.8%). Only 13.7% of lay- or self-treated reactions to food and 27.6% of insect anaphylaxis received on-site adrenaline. CONCLUSION: This pilot phase of a pan-European registry for severe allergic reactions provides for the first time data on anaphylaxis throughout Europe, demonstrates its potential functionality and allows a comparison of symptom patterns, elicitors and treatment habits between referral centres and countries.
Papaioannou TG, Soulis D, Vardoulis O, Protogerou A, Sfikakis PP, Stergiopulos N, Stefanadis C. First in vivo application and evaluation of a novel method for non-invasive estimation of cardiac output. Medical Engineering and Physics [Internet]. 2014;36(10):1352 - 1357. Website
Gardikas K. Fish farming and malaria in modern Greece: conflicting interests or tragedy of the commons?. In: Franchomme M, Labeur C, Quatrida D, Simonetti R Les zones humides méditerranéennes hier et aujourd’hui - Le zone umide mediterranee ieri e oggi. Padova: Padova University Press; 2014.
Moser A. From Aktionsart to aspect: grammaticalization and subjectifica­tion in Greek. Acta Linguistica Hafniensia [Internet]. 2014;46(3):955-965. Publisher's VersionAbstract
This article proposes an analysis of the historical changes in the aspectual system of Greek as a process of grammaticalization and subjectification, thus challenging the traditional view of Greek verbal aspect as a stable and in fact extremely conservative category, possibly very close to that of Proto-Indo- European. Specifically, the claim put forward here is that the original tripartite morphological opposition (Aorist – Present – Perfect stems) expressed Aktionsart, i.e. lexical aspect, distinctions (punctuality/telicity– durativity/atelicity–state, respectively) while the modern binary morpho- logical opposition (Aorist–Present stems) expresses the purely aspectual perfective–imperfective opposition. Since Aktionsart is based on inherent features of the action/state denoted by the verb while aspect expresses the speaker’s point of view, this constitutes a shift from objectivity to subjectivity as well as a somewhat atypical grammaticalization process. Keywords: gradient; perfective; progressive; habitual; perfect 
Tsimpouki T. The Frontier, the Dreamer and the Dream: Crane, Roth and the Urgencies of American Nationhood. In: Philip Roth and World Literature: Transatlantic Perspectives and Uneasy Passages. Cambria Press; 2014.
Vavouranakis G. Funerary pithoi in Bronze Age Crete: their introduction and significance at the threshold of Minoan palatial society. American Journal of Archaeology. 2014;118(2):197-222.
Zerefos CS, Tetsis P, Amiridis V, Zerefos CS, Luterbacher J, Eleftheratos K, Gerasopoulos E, Kazadzis S, Papayannis A. Further evidence of important environmental information content in red-to-green ratios as depicted in paintings by great masters. Atmos. Chem. Phys. [Internet]. 2014;14:2987-3015. Publisher's Version a21_acp_2014.pdf
Purrington KS, Slager S, Eccles D, Yannoukakos D, Fasching PA, Miron P, Carpenter J, Chang-claude J, Martin NG, Montgomery GW, et al. Genome-wide association study identifies 25 known breast cancer susceptibility loci as risk factors for triple-negative breast cancer. Carcinogenesis [Internet]. 2014;35(5):1012 - 1019. WebsiteAbstract
Triple-negative (TN) breast cancer is an aggressive subtype of breast cancer associated with a unique set of epidemiologic and genetic risk factors. We conducted a two-stage genome-wide association study of TN breast cancer (stage 1: 1529 TN cases, 3399 controls; stage 2: 2148 cases, 1309 controls) to identify loci that influence TN breast cancer risk. Variants in the 19p13.1 and PTHLH loci showed genome-wide significant associations (P < 5 × 10-8) in stage 1 and 2 combined. Results also suggested a substantial enrichment of significantly associated variants among the single nucleotide polymorphisms (SNPs) analyzed in stage 2. Variants from 25 of 74 known breast cancer susceptibility loci were also associated with risk of TN breast cancer (P < 0.05). Associations with TN breast cancer were confirmed for 10 loci (LGR6, MDM4, CASP8, 2q35, 2p24.1, TERT-rs10069690, ESR1, TOX3, 19p13.1, RALY), and we identified associations with TN breast cancer for 15 additional breast cancer loci (P < 0.05: PEX14, 2q24.1, 2q31.1, ADAM29, EBF1, TCF7L2, 11q13.1, 11q24.3, 12p13.1, PTHLH, NTN4, 12q24, BRCA2, RAD51L1-rs2588809, MKL1). Further, two SNPs independent of previously reported signals in ESR1 [rs12525163 odds ratio (OR) = 1.15, P = 4.9 × 10-4] and 19p13.1 (rs1864112 OR = 0.84, P = 1.8 × 10-9) were associated with TN breast cancer. A polygenic risk score (PRS) for TN breast cancer based on known breast cancer risk variants showed a 4-fold difference in risk between the highest and lowest PRS quintiles (OR = 4.03, 95% confidence interval 3.46-4.70, P = 4.8 × 10-69). This translates to an absolute risk for TN breast cancer ranging from 0.8% to 3.4%, suggesting that genetic variation may be used for TN breast cancer risk prediction.
Alexopoulos JD, Dilalos S, Vassilakis E, Michelioudakis D, Mavroulis S, Farangitakis P. A geophysical insight for the occurrence of Mediterranean temporary ponds, on Mts. Oiti and Kallidromo (Greece). In: 20th European Meeting of Environmental and Engineering Geophysics. Athens; 2014. pdf
Alexopoulos JD, Dilalos S, Vassilakis E, Michelioudakis D, Mavroulis S, Farangitakis P. A geophysical insight for the occurrence of Mediterranean temporary ponds, on Mts. Oiti and Kallidromo (Greece). In: 20th European Meeting of Environmental and Engineering Geophysics. Athens; 2014. Publisher's Version
Demoly P, Tanno LK, Akdis CA, Lau S, Calderon MA, Santos AF, Sanchez-Borges M, Rosenwasser LJ, Pawankar R, Papadopoulos NG. Global classification and coding of hypersensitivity diseases - An EAACI - WAO survey, strategic paper and review. Allergy. 2014;69(5):559-70.Abstract
Hypersensitivity diseases are not adequately coded in the International Coding of Diseases (ICD)-10 resulting in misclassification, leading to low visibility of these conditions and general accuracy of official statistics. To call attention to the inadequacy of the ICD-10 in relation to allergic and hypersensitivity diseases and to contribute to improvements to be made in the forthcoming revision of ICD, a web-based global survey of healthcare professionals' attitudes toward allergic disorders classification was proposed to the members of European Academy of Allergy and Clinical Immunology (EAACI) (individuals) and World Allergy Organization (WAO) (representative responding on behalf of the national society), launched via internet and circulated for 6 week. As a result, we had 612 members of 144 countries from all six World Health Organization (WHO) global regions who answered the survey. ICD-10 is the most used classification worldwide, but it was not considered appropriate in clinical practice by the majority of participants. The majority indicated the EAACI-WAO classification as being easier and more accurate in the daily practice. They saw the need for a diagnostic system useful for nonallergists and endorsed the possibility of a global, cross-culturally applicable classification system of allergic disorders. This first and most broadly international survey ever conducted of health professionals' attitudes toward allergic disorders classification supports the need to update the current classifications of allergic diseases and can be useful to the WHO in improving the clinical utility of the classification and its global acceptability for the revised ICD-11.
Molou E, Schulpis KH, Thodi G, Georgiou V, Dotsikas Y, Papadopoulos K, Biti S, Loukas YL. Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency in Greek newborns: The Mediterranean C563T mutation screening. Scandinavian Journal of Clinical and Laboratory Investigation [Internet]. 2014;74(3):259 - 263. Website
Spanaki IE, Venetsanou F, Evaggelinou C, Skordilis EK. Graphomotor skills of Greek kindergarten and elementary school children: effect of a fine motor intervention program. Innovative Teaching. 2014;3(2).
Syrengelas D, Kalampoki V, Kleisiouni P, Konstantinou D, Siahanidou T. Gross motor development in full-term Greek infants assessed by the Alberta Infant Motor Scale: Reference values and socioeconomic impact. Early Hum Dev. 2014;90:353-7.Abstract
OBJECTIVE: The aims of this study were to investigate gross motor development in Greek infants and establish AIMS percentile curves and to examine possible association of AIMS scores with socioeconomic parameters. METHODS: Mean AIMS scores of 1068 healthy Greek full-term infants were compared at monthly age level with the respective mean scores of the Canadian normative sample. In a subgroup of 345 study participants, parents provided, via interview, information about family socioeconomic status. Multiple linear regression analysis was performed to evaluate the relationship of infant motor development with socioeconomic parameters. RESULTS: Mean AIMS scores did not differ significantly between Greek and Canadian infants in any of the 19 monthly levels of age. In multiple linear regression analysis, the educational level of the mother and also whether the infant was being raised by grandparents/babysitter were significantly associated with gross motor development (p=0.02 and p<0.001, respectively), whereas there was no significant correlation of mean AIMS scores with gender, birth order, maternal age, paternal educational level and family monthly income. CONCLUSIONS: Gross motor development of healthy Greek full-term infants, assessed by AIMS during the first 19months of age, follows a similar course to that of the original Canadian sample. Specific socioeconomic factors are associated with the infants’ motor development.
Matiatos J, Paraskevopoulou V, Dassenakis M, Alexopoulos J, Panagopoulos A, Lazogiannis K, Poulos S, Arampatzis G, Ghionis G, Kotsopoulos S, et al. Groundwater flow regime and quality assessment of the alluvial aquifer in the deltaic environment of river Pinios (Thessaly). In: 10th International Hydrogeological Congress of Greece. Vol. 1. ; 2014. pp. 437-446. Publisher's Version
Thomakos N, Zacharakis D, Rodolakis A, Zagouri F, Papadimitriou CA, Bamias A, Dimopoulos M-A, Haidopoulos D, Vlahos G, Antsaklis A. Gynecologic oncology patients in the surgical high dependency unit: An analysis of indications. Archives of Gynecology and Obstetrics [Internet]. 2014;290(2):335 - 339. WebsiteAbstract
Purpose: The establishment of high dependency units (HDUs) has been an undoubted advance in the management of patients undergoing major oncological procedures. The aim of this study was to examine the impact of various preoperative and perioperative patients' characteristics on the prolonged HDU stay. Methods: We conducted a retrospective study including all gynecologic oncology patients who underwent surgical management and were admitted postoperatively to our hospitals' HDU from 2006 to 2010. Results: A total of 1,014 patients were transferred to the HDU and divided into two groups according to the length of HDU stay. Group A consisted of 840 (82.8 %) patients who stayed in the HDU for ≤24 h and Group B included 174 (17.2 %) patients who remained in the HDU under close observation for >24 h. Older age was the only preoperative characteristic that remained significantly associated with HDU prolonged stay. In addition, three intraoperative factors such as use of invasive hemodynamic monitoring, bowel resection and estimated blood loss were proved to be independently associated with prolonged HDU stay. Conclusion: Certain characteristics could identify those patients who are more likely to benefit most from HDU admission. © 2014 Springer-Verlag.
Zhu CW, Scarmeas N, Ornstein K, Albert M, Brandt J, Blacker D, Sano M, Stern Y. Health-care use and cost in dementia caregivers: Longitudinal results from the Predictors Caregiver Study. Alzheimers Dement. 2014.Abstract
OBJECTIVE: To examine the effects of caregiver and patient characteristics on caregivers' medical care use and cost. METHODS: One hundred forty-seven caregiver/patient dyads were followed annually for 6 years in three academic Alzheimer's disease centers in the United States. Logistic, negative binomial, and generalized linear mixed models were used to examine overall effects of caregiver/patient characteristics on caregivers' hospitalizations, doctor visits, outpatient tests and procedures, and prescription and over-the-counter medications. RESULTS: Patients' comorbid conditions and dependence were associated with increased health-care use and costs of caregivers. Increases in caregiver depressive symptoms are associated with increases in multiple domains of caregivers' health-care use and costs. DISCUSSION: Findings suggest expanding our focus on dementia patients to include family caregivers to obtain a fuller picture of effects of caregiving. Primary care providers should integrate caregivers' needs in health-care planning and delivery. Clinical interventions that treat patients and caregivers as a whole will likely achieve the greatest beneficial effects.
Goossens NJ, Flokstra-de Blok BMJ, van der Meulen GN, Arnlind MH, Asero R, Barreales L, Burney P, Cerecedo I, Clausen M, Fernandéz-Rivas M, et al. Health-related quality of life in food-allergic adults from eight European countries. Ann Allergy Asthma Immunol. 2014;113(1):63-68.e1.Abstract
BACKGROUND: Food allergy can impair health-related quality of life (HRQL). Food Allergy Quality of Life Questionnaires (FAQLQs) have been developed and validated, including an adult form (FAQLQ-AF). HRQL has not, to date, been measured across different European countries using a uniform methodology. OBJECTIVE: To translate and validate the FAQLQ-AF for use in 8 European countries (Iceland, The Netherlands, Poland, France, Spain, Italy, Greece, and Sweden). METHODS: The English FAQLQ-AF was translated, back-translated, and compared for use in the 8 relevant European languages. Adults with a perceived food allergy were recruited from outpatient departments and through a community survey. Participants completed the FAQLQ-AF, the Food Allergy Independent Measure, and questions concerning participants' characteristics. Validity of the FAQLQ-AF was analyzed for use in the 8 countries. RESULTS: The FAQLQ-AF had strong construct validity (r > 0.59) and an excellent internal consistency (Cronbach α > 0.95) in all countries. Total FAQLQ-AF scores (range 3.2-5.0) were significantly different across participating countries. CONCLUSION: The FAQLQ-AF is a suitable and valid instrument for measuring HRQL in food-allergic adults in Iceland, The Netherlands, Poland, France, Spain, Italy, Greece, and Sweden. The impact of food allergy on HRQL seems to differ among adults from the 8 participating European countries.
Moustris KP, Kavadias K, Nastos PT, Larissi IK, Paliatsos AG. HEAT STRESS CONDITIONS IN THE GREEK TERRITORY WITHIN THE WARM PERIOD OF THE YEAR. FRESENIUS ENVIRONMENTAL BULLETIN. 2014;23:3068–3076.
Dardiotis E, Kosmidis MH, Yannakoulia M, Hadjigeorgiou GM, Scarmeas N. The Hellenic Longitudinal Investigation of Aging and Diet (HELIAD): Rationale, Study Design, and Cohort Description. Neuroepidemiology. 2014;43(1):9-14.Abstract
Background: Accumulating epidemiological evidence from several populations supports the important role of the Mediterranean-type diet (MeDi) in reducing the risk for age-related diseases such as Alzheimer's disease (AD). However, the relevant literature is clearly deficient for most Mediterranean countries that more closely adhere to the originally described MeDi. Greece resides in the Mediterranean basin, and older generations traditionally adhere to a MeDi. Methods: We here present the design and the preliminary baseline characteristics of the Hellenic Longitudinal Investigation of Aging and Diet (HELIAD). The HELIAD is a population-based, multidisciplinary, collaborative study designed to estimate the prevalence and incidence of AD, other dementias, mild cognitive impairment, and other neuropsychiatric conditions of aging in the Greek population and to investigate associations between nutrition and cognitive dysfunction/age-related neuropsychiatric diseases in this Mediterranean population. The study also ascertains several demographic, medical, social, environmental, clinical, nutritional, and neuropsychological determinants and lifestyle activities. Results: In total, 1,050 participants of a random sample have already completed the initial evaluation. The subjects were, on average, 73.4 (SD = 6.0) years old, 60% of the sample were female, and most of the participants were poorly educated with an average of 5.41 (SD = 3.5) years of education. The performance on the neuropsychological tests was equivalent to the average scores of previous normative Greek samples. More than one third of the population under investigation was considered to be at high risk for malnutrition. Conclusions: The HELIAD may provide important data for expanding our knowledge regarding the prevalence, incidence, and risk factors of AD and several other neuropsychiatric diseases in the Mediterranean region. © 2014 S. Karger AG, Basel.
Gkotzamanidou M, Terpos E, Kastritis E, Dimopoulos MA. Hematologic response and stabilization of renal function in a patient with light chain deposition disease after lenalidomide treatment: A novel therapeutic approach?. Clinical Lymphoma, Myeloma and Leukemia [Internet]. 2014;14(5):e179 - e181. Website
Karakassi K. Hermann Broch oder die Romantik Karakassi K, Lindinger S, Mark M. Deutsche Romantik.Transformationen Und Transgressionen. 2014:169 - 180.
Baar A, Pahr S, Constantin C, Giavi S, Papadopoulos NG, Pelkonen AS, Mäkelä MJ, Scheiblhofer S, Thalhamer J, Weber M, et al. The high molecular weight glutenin subunit Bx7 allergen from wheat contains repetitive IgE epitopes. Allergy. 2014;69(10):1316-1323.Abstract
BACKGROUND: Wheat is one of the most common food allergen sources for children and adults. The aim of this study was to characterize new wheat allergens using an IgE discovery approach and to investigate their IgE epitopes. METHODS: A cDNA expression library representing the wheat transcriptome was constructed in phage lambda gt11 and screened with IgE antibodies from wheat food allergic patients. IgE-reactive cDNA clones coding for portions of high molecular weight (HMW) glutenin subunits were identified by sequence analysis of positive clones. IgE epitopes were characterized using recombinant fragments from the HMW Bx7 and synthetic peptides thereof for testing of allergic patients' sera and in basophil degranulation assays. RESULTS: We found that the major IgE-reactive areas of HMW glutenins are located in the repetitive regions of the protein and could show that two independent IgE-reactive fragments from HMW Bx7 contained repetitive IgE epitopes. CONCLUSIONS: Our results demonstrate that IgE antibodies from wheat food allergic patients can recognize repetitive epitopes in one of the important wheat food allergens. Recombinant HMW Bx7 may be included into the panel of allergens for component-resolved diagnosis of wheat food allergy.
Higher Education Law. Athens: Nomiki Vivliothiki; 2014 pp. 520. Publisher's Version
Kouroutzoglou J, Flocas HA, Hatzaki M, Keay K, Simmonds I. A high-resolution climatological study on the comparison between surface explosive and ordinary cyclones in the Mediterranean. Regional Environmental Change [Internet]. 2014;14(5):1833 - 1846. Website
Alexandrakis G, Poulos SE. An holistic approach to beach erosion vulnerability assessment. Scientific Reports [Internet]. 2014;4. Website
Poulos SE, Ghionis G, Verykiou E, Roussakis G, Sakellariou D, Karditsa A, Alexandrakis G, Petrakis S, Sifnioti D, Panagiotopoulos IP, et al. {Hydrodynamic, neotectonic and climatic control of the evolution of a barrier beach in the microtidal environment of the NE Ionian Sea (eastern Mediterranean)}. Geo-Marine Letters [Internet]. 2014. Website
Poulos SE, Ghionis G, Verykiou E, Roussakis G, Sakellariou D, Karditsa A, Alexandrakis G, Petrakis S, Sifnioti D, Panagiotopoulos IP, et al. Hydrodynamic, neotectonic and climatic control of the evolution of a barrier beach in the microtidal environment of the NE Ionian Sea (eastern Mediterranean). Geo-Marine Letters [Internet]. 2014;35:37-52. Website
Anoussis M, Katavolos A, Todorov IG. Ideals of {$A(G)$} and bimodules over maximal abelian selfadjoint algebras. J. Funct. Anal. [Internet]. 2014;266:6473–6500. Website
Grase A, Zimmermann T, NG P, Vuorinen T, S F. IL-17A and its anti-viral properties in alergic asthma. Allergy. 2014;69:590.
Zagouri F, Kastritis E, Symeonidis AS, Giannakoulas N, Katodritou E, Delimpasi S, Repousis P, Terpos E, Dimopoulos MA. Immunoglobulin D myeloma: Clinical features and outcome in the era of novel agents. European Journal of Haematology [Internet]. 2014;92(4):308 - 312. WebsiteAbstract
Objectives: Immunoglobulin D (IgD) multiple myeloma is an uncommon variant of the disease probably associated with poorer prognosis. However, data on IgD myeloma patients treated in the novel agent era are lacking. Methods: To assess the frequency and the specific characteristics and evaluate the outcome of patients with IgD myeloma, we analyzed the database of the Greek Myeloma Study Group. Results: Between January 2000 and December 2012, among the 1239 patients with symptomatic myeloma, 31 (2.5%) were diagnosed with IgD myeloma. The median age of patients with IgD myeloma was 65 yr (range 26-80 yr) versus 68 yr (range 23-96 yr) of all others, and 84% had lambda light chain (vs. 38% of the patients with other subtypes). Patients with IgD myeloma presented more often with features of high-risk disease, that is, with advanced ISS, high LDH, significant renal dysfunction, and large amounts of Bence Jones proteinuria. Response to primary therapy was similar to other patients, although there was a trend for better quality of responses in patients with IgD myeloma. The median survival of these patients was 51.5 months versus 50.7 months for patients of other subtypes. In a multivariate model to adjust for differences in prognostic features, IgD myeloma was not associated with a different prognosis. Conclusion: The incidence of IgD myeloma is 2.5%. Although patients with IgD myeloma present more often with high-risk features, their outcome in the era of novel agents is similar to that of patients with other myeloma subtypes. © 2013 John Wiley & Sons A/S.
Eichhorn S, Pablos I, Laimer J, Jensen BM, Versteeg S, Lackner P, Zuidmeer-Jongejan L, Fernandez-Rivas M, Papadopoulos NG, Mari A, et al. Immunological characterization of a pru p3 proline variant for treatment of LTP-related peach allergy. 2014;69:1.
Theodoraki K, Markatou M, Rizos D, Fassoulaki A. The impact of two different transfusion strategies on patient immune response during major abdominal surgery: A preliminary report. Journal of Immunology Research. 2014;2014.Abstract
Blood transfusion is associated with well-known risks. We investigated the difference between a restrictive versus a liberal transfusion strategy on the immune response, as expressed by the production of inflammatory mediators, in patients subjected to major abdominal surgery procedures. Fifty-eight patients undergoing major abdominal surgery were randomized preoperatively to either a restrictive transfusion protocol or a liberal transfusion protocol (with transfusion if hemoglobin dropped below 7.7 g dL-1 or 9.9 g dL -1, respectively). In a subgroup of 20 patients randomly selected from the original allocation groups, blood was sampled for measurement of IL-6, IL-10, and TNFα. Postoperative levels of IL-10 were higher in the liberal transfusion group on the first postoperative day (49.82 ± 29.07 vs. 15.83 ± 13.22 pg mL-1, P < 0.05). Peak postoperative IL-10 levels correlated with the units of blood transfused as well as the mean duration of storage and the storage time of the oldest unit transfused (r 2 = 0.38, P = 0.032, r2 = 0.52, P = 0.007, and r 2 = 0.68, P < 0.001, respectively). IL-10 levels were elevated in patients with a more liberal red blood cell transfusion strategy. The strength of the association between anti-inflammatory IL-10 and transfusion variables indicates that IL-10 may be an important factor in transfusion-associated immunomodulation. This trial is registered under ClinicalTrials.gov Identifier: NCT02020525. © 2014 Kassiani Theodoraki et al.
Karavas E. Implementing innovation in primary EFL: A case study in Greece. ELT Journal Special Issue 2014 "Teaching English to Young Learners" [Internet]. 2014;68(3):243-253. Publisher's VersionAbstract
The purpose of this article is to highlight and discuss the strategies used to diffuse and manage a primary ELT innovation in Greece, strategies that proved essential for developing stakeholders’ acceptance and ownership of the innovation, thereby facilitating its further development and sustainability. The PEAP Programme, launched in 2010, involved the introduction of EFL in the first and second grades of public primary schools in Greece. The extent of its impact and acceptance by teachers and other stakeholders was unexpected given the fact that the project was developed and implemented within a context of social and political instability and massive public sector and economic reform. The strategies reported in this article have implications for the successful management and implementation of primary EFL innovations in Europe and elsewhere.
Drikos S, Kountouris P. The importance of certain performance indicators on specific set types in Volleyball. Inquiries in Sport & Physical Education. [Internet]. 2014;12(1):17–25. Publisher's Version
Alexandrou A, Dimitriou N, Levidou G, Griniatsos J, Sougioultzis S, Korkolopoulou P, Felekouras E, Pikoulis E, Diamantis T, Tsigris C, et al. The incidence of HPV infection in anal cancer patients in Greece. Acta Gastroenterol Belg. 2014;77:213-216.Abstract
Background and aim of the study : Although anal cancer represents a relatively uncommon malignancy, its incidence over the last five decades, has been reported as increased for both sexes, worldwide. Human papillomavirus (HPV) infection has been shown to be a major cause for its development. The aim of the present study is to report on clinical, epidemiological and virological data of squamous anal cancer in Greek patients. Patients and Method : Between January 2002 and December 2010, 11 Greek patients (6 females) who were diagnosed as suffering from squamous cell anal or perianal cancer, were treated in our Hospital. Formalin fixed paraffin embedded tissue samples, obtained at the time of the anal biopsy or surgery, were analyzed by PCR in order to identify the presence as well as the type of HPV infection. Results : Overall, the presence of HPV DNA was detected in 6 out of the 11 patients (54.5%). The “highrisk” HPV DNA was  detected in 3 of them (2 women and 1 man), while the “lowrisk” HPV DNA was detected in the remaining three (2 women and 1 man). Conclusion : The incidence of HPV infection in squamous cell anal cancer Greek patients, is lower than other Western countries, probably reflecting differences in sexual habits in the Greek  population
Asimakopoulou E-M, Madesis I, Dimitriou A, Zouros TJM, Mertzimekis TJ, Lagoyannis A, Axiotis M. Incorporation of an Ion Post Stripper for the APAPES Experimental Setup. In: Hellenic Nuclear Physics Society; 2014.
Guibas GV, Manios Y, Moschonis G, Xepapadaki P, Roumpedaki E, Lambrinou C-P, Papadopoulos NG. Infantile growth velocity and later asthma/wheeze: GENESIS and the Healthy Growth Study. Eur Respir J. 2014;43(6):1790-3.
Guibas G, Manios Y, Moschonis G, Xepapadaki P, Roumpedaki E, Lambrinou C, Papadopoulos NG. Infantile growth velocity and later asthma/wheeze: GENESIS and the Healthy Growth Study. European Respiratory Journal. 2014.
Miletic V, Maniadakis D, Mikac B, Varoutas D. On the influence of the underlying network topology on optical telecommunication network availability under shared risk link group failures. In: Design of Reliable Communication Networks (DRCN), 2014 10th International Conference on the. IEEE; 2014. pp. 1–8.
Kokotos G, Feuerherm AJ, Barbayianni E, Shah I, Saether M, Magrioti V, Nguyen T, Constantinou-Kokotou V, Dennis EA, Johansen B. Inhibition of group IVA cytosolic phospholipase A2 by thiazolyl ketones in vitro, ex vivo, and in vivo. Journal of Medicinal Chemistry. 2014;57:7523-7535.Abstract
Group IVA cytosolic phospholipase A2 (GIVA cPLA2) is the rate-limiting provider of pro-inflammatory mediators in many tissues and is thus an attractive target for the development of novel anti-inflammatory agents. In this work, we present the synthesis of new thiazolyl ketones and the study of their activities in vitro, in cells, and in vivo. Within this series of compounds, methyl 2-(2-(4-octylphenoxy)acetyl)thiazole-4-carboxylate (GK470) was found to be the most potent inhibitor of GIVA cPLA2, exhibiting an XI(50) value of 0.011 mole fraction in a mixed micelle assay and an IC50 of 300 nM in a vesicle assay. In a cellular assay using SW982 fibroblast-like synoviocytes, it suppressed the release of arachidonic acid with an IC50 value of 0.6 μM. In a prophylactic collagen-induced arthritis model, it exhibited an anti-inflammatory effect comparable to the reference drug methotrexate, whereas in a therapeutic model, it showed results comparable to those of the reference drug Enbrel. In both models, it significantly reduced plasma PGE2 levels.
Petrakis PE, Kostis PC, Valsamis DG. Innovation and Competitiveness: Culture as a Long-Term Strategic Instrument: Culture on Innovation and Competitiveness during the European Great Recession. In: 3rd Global Innovation and Knowledge Academy (GIKA) Conference. Valencia, Spain; 2014.
Zervou M, Cournia Z, Potamitis C, Patargias G, Durdagi S, Grdadolnik SG, Mavromoustakos T. Insights into the molecular basis of action of the AT1 antagonist losartan using a combined NMR spectroscopy and computational approach. Biochimica et Biophysica Acta - Biomembranes [Internet]. 2014;1838(3):1031 - 1046. Website
Pappa EP, Christopoulou ME, Mertzimekis TJ, Nomikou P, Carey S, Polymenakou P, Papanikolaou D. In-situ CTD scans as a probe for submarine volcano. [Internet]. 2014. Website
Sagonas K, Pafilis P, Lymberakis P, Donihue CM, Herrel A, Valakos ED. Insularity affects head morphology, bite force and diet in a Mediterranean lizard. Biological Journal of the Linnean Society. 2014;112:469-484.Abstract
Island environments differ with regard to numerous features from the mainland and may induce large-scale changes in most aspects of the biology of an organism. In this study, we explore the effect of insularity on the morphology and performance of the feeding apparatus, a system crucial for the survival of organisms. To this end, we examined the head morphology and feeding ecology of island and mainland populations of the Balkan green lizard, Lacerta trilineata. We predicted that head morphology, performance and diet composition would differ between sexes and habitats as a result of varying sexual and natural selection pressures. We employed geometric morphometrics to test for differences in head morphology, measured bite forces and analysed the diet of 154 adult lizards. Morphological analyses revealed significant differences between sexes and also between mainland and island populations. Relative to females, males had larger heads, a stronger bite and consumed harder prey than females. Moreover, island lizards differed in head shape, but not in head size, and, in the case of males, demonstrated a higher bite force. Islanders had a wider food niche breadth and included more plant material in their diet. Our findings suggest that insularity influences feeding ecology and, through selection on bite force, head morphology. © 2014 The Linnean Society of London, Biological Journal of the Linnean Society, 2014, ●●, ●●–●●.
Agrogiannis G, Patsouris E, Konstantinidou A. Insulin like growth factor 1 and Growth hormone expression in embryonic and fetal period. VIRCHOWS ARCHIV. 2014;465:S203-S203.
Agrogiannis GD, Sifakis S, Patsouris ES, Konstantinidou AE. Insulin-like growth factors in embryonic and fetal growth and skeletal development (Review). Molecular medicine reports. 2014;10(2):579-584.
Bousquet J, Addis A, Adcock I, Agache I, Agusti A, Alonso A, Annesi-Maesano I, Anto JM, Bachert C, Baena-Cagnani CE, et al. Integrated care pathways for airway diseases (AIRWAYS-ICPs). Eur Respir J. 2014;44(2):304-23.Abstract
The objective of Integrated Care Pathways for Airway Diseases (AIRWAYS-ICPs) is to launch a collaboration to develop multi-sectoral care pathways for chronic respiratory diseases in European countries and regions. AIRWAYS-ICPs has strategic relevance to the European Union Health Strategy and will add value to existing public health knowledge by: 1) proposing a common framework of care pathways for chronic respiratory diseases, which will facilitate comparability and trans-national initiatives; 2) informing cost-effective policy development, strengthening in particular those on smoking and environmental exposure; 3) aiding risk stratification in chronic disease patients, using a common strategy; 4) having a significant impact on the health of citizens in the short term (reduction of morbidity, improvement of education in children and of work in adults) and in the long-term (healthy ageing); 5) proposing a common simulation tool to assist physicians; and 6) ultimately reducing the healthcare burden (emergency visits, avoidable hospitalisations, disability and costs) while improving quality of life. In the longer term, the incidence of disease may be reduced by innovative prevention strategies. AIRWAYSICPs was initiated by Area 5 of the Action Plan B3 of the European Innovation Partnership on Active and Healthy Ageing. All stakeholders are involved (health and social care, patients, and policy makers).
Chrysostomou S. Interactive text books in the music classroom: applications of an innovative project in Greece and Cyprus. International Society for Music Education 31st conference - Proceedings. 2014.
Palumbo A, Rajkumar SV, San Miguel JF, Larocca A, Niesvizky R, Morgan G, Landgren O, Hajek R, Einsele H, Anderson KC, et al. International Myeloma Working Group consensus statement for the management, treatment, and supportive care of patients with myeloma not eligible for standard autologous stem-cell transplantation. Journal of Clinical Oncology [Internet]. 2014;32(6):587 - 600. WebsiteAbstract
Purpose: To provide an update on recent advances in the management of patients with multiple myeloma who are not eligible for autologous stem-cell transplantation. Methods: A comprehensive review of the literature on diagnostic criteria is provided, and treatment options and management of adverse events are summarized. Results: Patients with symptomatic disease and organ damage (ie, hypercalcemia, renal failure, anemia, or bone lesions) require immediate treatment. The International Staging System and chromosomal abnormalities identify high- and standard-risk patients. Proteasome inhibitors, immunomodulatory drugs, corticosteroids, and alkylating agents are the most active agents. The presence of concomitant diseases, frailty, or disability should be assessed and, if present, treated with reduced-dose approaches. Bone disease, renal damage, hematologic toxicities, infections, thromboembolism, and peripheral neuropathy are the most frequent disabling events requiring prompt and active supportive care. Conclusion: These recommendations will help clinicians ensure the most appropriate care for patients with myeloma in everyday clinical practice. © 2