Publications

2016
FORBIDDEN AESTHETICS, ETHICAL JUSTICE, TERROR IN MODERN WESTERN CULTURE. Lanham, Maryland, USA: LEXINGTON BOOKS (ROWMAN & LITTLEFIELD), USA; 2016 pp. 200.
Georgiopoulos GA, Lambrinoudaki I, Athanasouli F, Armeni E, Rizos D, Kazani M, Karamanou M, Manios E, Augoulea A, Stellos K, et al. Free androgen index as a predictor of blood pressure progression and accelerated vascular aging in menopause. Atherosclerosis. 2016;247:177 - 183.Abstract
© 2016 Elsevier Ireland Ltd. Background and aims: We aimed to assess the prognostic value of free androgen index (FAI) and its change over time in arterial stiffness progression, endothelial function and hypertension in postmenopausal women. Methods: Postmenopausal women (n = 180) without clinically overt cardiovascular disease or diabetes were consecutively recruited and followed for a median of 29 months. The main outcome measures were changes over time in endothelial function (FMD), reflected waves, localized and systemic (PWV) arterial stiffness and hypertension. Results: Increased baseline FAI was significantly associated with new onset hypertension (OR for each SD, 2.71, 95% CI 1.14-6.41, p = 0.024), deterioration of pulse wave velocity (PWV) (0.414 m/s per SD), flow-mediated dilation (FMD) (-0.42% per SD), systolic (2.5 mmHg per SD) and pulse pressure progression (2.3 mmHg per SD, p < 0.05 for all). Baseline FAI remained an independent predictor of changes in PWV (p = 0.006), FMD (p = 0.02), peripheral pulse pressure (p = 0.028), transition to new onset hypertension (p = 0.001) and higher BP category (p = 0.012), after adjustment for age, changes in systolic blood pressure, traditional risk factors, vasoactive medication or total testosterone. Baseline FAI improved reclassification for the risk of transition into higher BP category (NRI = 47.5 ± 20.3%, p = 0.02) and abnormal PWV (NRI = 53.4 ± 23.2%, p = 0.021). Similarly, in a subgroup of patients with measured FAI at follow-up, its changes over time predicted changes in PWV, peripheral pulse pressure and hypertension status (p < 0.05 for all). Conclusions: In apparently healthy postmenopausal women, FAI could be a novel biomarker superior to total testosterone for accelerated vascular aging and hypertension status.
Arabatzis T, Gavroglu K. From Discrepancy to Discovery: How Argon Became an Element. In: T. Sauer & R. Scholl (eds), The Philosophy of Historical Case Studies. Dordrecht: Springer; 2016. pp. 203-222. Publisher's VersionAbstract
In this paper, we revisit the discovery of argon by Lord Rayleigh and William Ramsay. We argue that to understand historically how argon was detected, conceptualized, and accommodated into chemical knowledge we need to take into account the philosophical insight that scientific discovery is often an extended process. One of argon’s most intriguing properties was that it did not react with other elements. Reactivity, however, had been a constitutive property of elements. Thus, the discovery of argon could not have been accepted by chemists without a reconceptualization of ‘element’. Furthermore, there were difficulties with the accommodation of argon in the Periodic table, because argon appeared to undermine the conception of matter that underlay the Periodic table. The discovery of argon was complete only after those conceptual difficulties had been removed. This is why it has to be understood as an extended process, rather than as an event. Furthermore, we will suggest that some of the factors that complicated the discovery of argon were related to the legitimization of physical techniques of investigation in chemistry and the emergence of physical chemistry.
Krase AA, Papadimas GK, Terzis GD. Functional capacity in a late-onset Pompe disease patient: Effect of enzyme replacement therapy and exercise training. Ann Indian Acad Neurol. 2016;19(3):423-4.
Goulas V, Stylos E, Chatziathanasiadou MV, Mavromoustakos T, Tzakos AG. Functional components of carob fruit: Linking the chemical and biological space. International Journal of Molecular Sciences [Internet]. 2016;17(11). Website
Goulas V, Stylos E, Chatziathanasiadou MV, Mavromoustakos T, Tzakos AG. Functional components of carob fruit: Linking the chemical and biological space. International Journal of Molecular Sciences [Internet]. 2016;17(11). Website
Chrysostomou S. Further Perspectives 2A. In: Oxford Handbook of Technology & Music Education. Oxford: Oxford University Press; 2016.
Kamberidou I. "A Futurist and Hybrid Scientist, the result of a Multidisciplinary Education". Irene Kamberidou interviews Eleni Antoniadou, multidisciplinary scientist in Artificial Organ Technology and President of the European Health Parliament. Interview for 1st European Celebration of Women in Computing (ECWC), Brussels, 25-26 April 2016 (womenincomputing.eu), organized by European European Centre for Women and Technology (ECWT):. 2016.Abstract
When citing:  Kamberidou, Irene (2016).  A Futurist and Hybrid Scientist, the result of a Multidisciplinary Education. Irene Kamberidou interviews Eleni Antoniadou, multidisciplinary scientist in Artificial Organ Technology and President of the European Health Parliament, 04/14/2016 - 12:25:  http://www.womenincomputing.eu/blog/470/futurist-and-hybrid-scientist-result-multidisciplinary-education-irene-kamberidou-ecwt    Interview for  1st European Celebration of Women in Computing (ECWC), Brussels, 25-26 April 2016! (womenincomputing.eu), organized by European European Centre for Women and Technology (ECWT): SPONSORS: http://womenincomputing.eu/sponsors Website: www.ecwt.eu
a_futurist_and_hybrid_scientist.pdf a_futurist_and_hybrid_scientist.pdf
Magiorkinis G, Angelis K, Mamais I, Katzourakis A, Hatzakis A, Albert J, Lawyer G, Hamouda O, Struck D, Vercauteren J, et al. The global spread of HIV-1 subtype B epidemic. Infect Genet Evol. 2016;46:169-179.Abstract
Human immunodeficiency virus type 1 (HIV-1) was discovered in the early 1980s when the virus had already established a pandemic. For at least three decades the epidemic in the Western World has been dominated by subtype B infections, as part of a sub-epidemic that traveled from Africa through Haiti to United States. However, the pattern of the subsequent spread still remains poorly understood. Here we analyze a large dataset of globally representative HIV-1 subtype B strains to map their spread around the world over the last 50years and describe significant spread patterns. We show that subtype B travelled from North America to Western Europe in different occasions, while Central/Eastern Europe remained isolated for the most part of the early epidemic. Looking with more detail in European countries we see that the United Kingdom, France and Switzerland exchanged viral isolates with non-European countries than with European ones. The observed pattern is likely to mirror geopolitical landmarks in the post-World War II era, namely the rise and the fall of the Iron Curtain and the European colonialism. In conclusion, HIV-1 spread through specific migration routes which are consistent with geopolitical factors that affected human activities during the last 50years, such as migration, tourism and trade. Our findings support the argument that epidemic control policies should be global and incorporate political and socioeconomic factors.
Charitaki E, Kastritis E, Petraki C, Liapis K, Adamidis K, Apostolou T, Christodoulidou C, Nikolopoulou N, Terpos E, Nakopoulou L, et al. Glomerular expression of matrix metalloproteinases in AL-amyloidosis and association with renal function at the time of kidney biopsy. Clinical Nephrology [Internet]. 2016;85(1):44 - 52. WebsiteAbstract
Background: Matrix metalloproteinases (MMPs) have been implicated in the pathophysiology of various renal diseases, however, there are limited data regarding their role in renal AL-amyloidosis. In the present study, we evaluated the glomerular expression of MMPs in renal-biopsy specimens containing AL-amyloid deposits. We also examined the association of MMPs with renal function at the time of diagnostic renal biopsy. Methods: We performed immunohistochemistry with monoclonal antibodies against MMP-1, MMP-2, MMP-3, MMP-9, and TIMP-1 in 19 kidney-biopsy specimens with AL-amyloidosis and 8 specimens from normal kidney tissue. We used clinical data of the patients at the time of kidney biopsy to evaluate the association between MMP expression and renal function. Results: We found increased MMP-1 and MMP-3 expression within the amyloid deposits and adjacent tissues in > 50% of the amyloid-positive biopsies, whereas MMP-1 and MMP-3 were negative in control samples. In contrast, we found no significant glomerular MMP-2 and TIMP-1 expression in amyloid-containing or normal kidneys. MMP-9 expression was found in the glomerular basement membrane equally in AL-amyloidosis and control specimens. The presence of MMP-1 and MMP-3 in the glomeruli of patients with AL-amyloidosis correlated with worse renal function at the time of kidney biopsy. Conclusion: The findings of this study show increased glomerular expression of MMP-1 and MMP-3 in patients with AL-amyloidosis which is associated with worse renal function at the time of the kidney biopsy. Our results suggest an important role for MMP-1 and MMP-3 in the pathogenesis of renal damage in AL-amyloidosis. © 2016 Dustri-Verlag Dr. K. Feistle.
Greek Art and Archaeology, 1200-30 BC. Atlanta: Lockwood Press; 2016. Publisher's VersionAbstract
Τhis lavishly illustrated book surveys Greek archaeology from the collapse of the Mycenaean palaces to the subordination of the last Hellenistic kingdoms to Rome. Its aim is to study Greek art through the material record, and against its cultural and social backdrop. The book's target audience is archaeology and art students, as well as anyone interested in Greek art and culture. Through concise, systematic covering of the main categories of classical monuments, the reader is taken to a tour of ancient Greece along the most spectacular period in its history, the 1st millennium BC. Architecture and city planning, sculpture, painting, pottery, metallurgy, jewelry, and numismatics are some of the areas covered.
Kamberidou I, Chroni S. The Greek Experience: Outstanding Women in the Social Space of Sport. In: Inspirational Women in Europe: making a difference in Physical Education, Sport and Dance. Juiz de Fora, Brazil.: Rosa Diketmüller (editor). Juiz de Fora : NGIME/UFJF, 2016. 254 p. (IAPESGW Continent Series). Publication of the International Association of Physical Education and Sport for Girls and Women (IAPESGW), ISBN 978-85-67380-55-1; 2016. pp. 224–242.Abstract
The Voices of Six Inspirational Greek Women in Sport: What inspired them to take that leap; the Obstacles they faced; how they moved forward and Tips for Success.  Many inspirational and outstanding women have made a difference in the lives of girls and women in sport, physical education (PE) and physical activity in Greece, despite their invisibility in the mainstream media, the life stories of which would need volumes. They succeeded in making a difference while respecting and celebrating diversity with regard to gender, ethnicity, culture, disability, age and sexual orientation. Beginning with a brief discussion on the underrepresentation of women’s sports and the female athlete in the Greek media, this chapter shares the contributions of some inspiring and motivating Greek women in sport whose achievements have been excluded from the country’s mainstream media. It is through six in-depth interviews and follow-up meetings that we learn how these pioneers influenced the lives of sporting girls and women by daring to disregard social barriers and spread awareness. We conclude the chapter with tips from these successful, namely inspirational women, who all agree that success requires ethos and taking that leap.http://www.ngime.ufjf.br/wp-content/uploads/Europa_opt.pdf
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Lambrinoudaki I, Augoulea A, Rizos D, Politi M, Tsoltos N, Moros M, Chinou I, Graikou K, Kouskouni E, Kambani S, et al. Greek-origin royal jelly improves the lipid profile of postmenopausal women. Gynecological Endocrinology [Internet]. 2016:1-5. Website
Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2016;12(1):1-222.
Thodi G, Schulpis KH, Dotsikas Y, Pavlides C, Molou E, Chatzidaki M, Triantafylli O, Loukas YL. Hawkinsinuria in two unrelated Greek newborns: Identification of a novel variant, biochemical findings and treatment. Journal of Pediatric Endocrinology and Metabolism [Internet]. 2016;29:15-20. Website
Nikolopoulos GK, Paraskevis D, Psichogiou M, Hatzakis A. HBV-DNA levels predict overall mortality in HIV/HBV coinfected individuals. J Med Virol. 2016;88(3):466-73.Abstract
The coinfection of Hepatitis B virus (HBV) and human immunodeficiency virus (HIV) has been associated with increased death rates. However, the relevant research has mostly relied on serologic HBV testing [HBV surface antigen (HBsAg)]. The aim of this work was to explore the relationship of HBV viraemia with overall mortality among HIV/HBV coinfected individuals. The analysis included 1,609 HIV seropositives of a previously described cohort (1984-2003) with limited exposure to tenofovir (12%) and a median follow-up of approximately 5 years. Those with persistent expression of HBsAg were further tested for HBV-DNA. The data were analyzed using Poisson regression models. Totally, 101 participants were chronic carriers of HBsAg (6.28%). Of these, 81 were tested for HBV-DNA. The median HBV-DNA levels were 3.81 log (base-10) International Units (IU)/ml. A third (31%) of those tested for HBV-DNA had received tenofovir. Before developing acquired immune deficiency syndrome (AIDS), the adjusted incidence rate ratio (IRR) for all-cause mortality of coinfected patients with HBV viraemia above the median value versus the HIV monoinfected group was 3.44 [95% confidence interval (CI): 1.05-11.27]. Multivariable regressions in the coinfected group only (n = 81) showed that one log-10 increase in HBV-DNA levels was associated with an elevated risk for death (IRR: 1.24, 95%CI: 1.03-1.49). HBV-DNA levels predict overall mortality in the setting of HIV/HBV coinfection, especially during the period before developing AIDS, and could thus help prioritize needs and determine the frequency of medical monitoring.
Papachristou E, Tsagkovits A, Zavitsanou A, Hatzakis A, Paraskevis D. HCV dispersal patterns among intravenous drug users (IDUs) in Athens metropolitan area. Infect Genet Evol. 2016;45:415-419.Abstract
BACKGROUND: Most of the HCV transmission the recent years in Greece was among IDUs. Our aim was to estimate the prevalence of HCV genotypes and to investigate the patterns of HCV dispersal among IDUs in Athens using current state of the art molecular epidemiology methods. METHODS: HCV sequences were determined from 238 HIV-negative IDUs collected on the basis of the "ARISTOTLE" prevention program carried out in Athens between 2012 and 2013. Phylogenetic trees were inferred on HCV sequences isolated from IDUs in Athens for the most prevalent HCV clades (subtypes 1a and 3a). Phylogenetic analysis was performed by Neighbor-Joining and Bayesian methods using GTR+G as nucleotide substitution model. HCV dispersal patterns were estimated using as references, all globally available HCV sequences for subtypes 1a and 3a. RESULTS: The prevalence of HCV subtypes was: 3a (59.2%), 1a (21.9%), 4 (13.0%), 1b (5.4%) and 2 (0.5%). Phylogenetic analyses revealed that most sequences (63.5%) οf subtypes 1a and 3a fell within IDU-specific monophyletic groups. The proportion of sequences in monophyletic clades was similar for subtype 3a (62.9%) and 1a (65.3%). For the latter group, monophyletic clades were smaller in size. Multivariable logistic regression analyses showed that monophyletic clustering was marginally associated recent onset of injecting ([AOR]=1.44; 95% CI (0.97-2.13), p=0.068). CONCLUSIONS: The high proportions of HCV sequences within IDU-specific monophyletic clusters suggest that transmissions occurred locally among IDUs in Greece. The numerous clusters for both 1a and 3a provide evidence that both sub-epidemics were the result of multiple introductions among the IDUs. Higher regional clustering was probably associated with a more recent onset of drug use.
Moustris KP, Proias GT, Larissi IK, Nastos PT, Koukouletsos KV, Paliatsos AG. Health impacts due to particulate air pollution in Volos City, Greece. Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering [Internet]. 2016;51:15-20. Website
Stewart AK, Dimopoulos MA, Masszi T, Špička I, Oriol A, Hájek R, Rosiñol L, Siegel DS, Niesvizky R, Jakubowiak AJ, et al. Health-related quality-of-life results from the open-label, randomized, phase III ASPIRE trial evaluating carfilzomib, lenalidomide, and dexamethasone versus lenalidomide and dexamethasone in patientswith relapsed multiple myeloma. Journal of Clinical Oncology [Internet]. 2016;34(32):3921 - 3930. WebsiteAbstract
Purpose To determine the effects of carfilzomib, lenalidomide, and dexamethasone (KRd) versus lenalidomide and dexamethasone (Rd) on health-related quality of life (HR-QoL) in the Carfilzomib, Lenalidomide, and Dexamethasone Versus Lenalidomide and Dexamethasone for the Treatment of Patients With Relapsed Multiple Myeloma (ASPIRE) trial. Methods Patients with relapsed multiple myeloma were randomly assigned to receive KRd or Rd. The European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire C30 and myeloma-specific module were administered at baseline; day 1 of cycles 3, 6, 12, and 18; and after treatment. The Global Health Status/Quality of Life (GHS/QoL) scale and seven subscales (fatigue, nausea and vomiting, pain, physical functioning, role functioning, disease symptoms, and adverse effects of treatment) were compared between groups using a mixed model for repeated measures. The percentages of responders with ≥ 5- or 15-point GHS/QoL improvement at each cycle were compared between groups. Results Baseline questionnaire compliance was excellent (94.1% of randomly assigned patients). KRd patients had higher GHS/QoL scores versus Rd patients over 18 treatment cycles (two-sided P<.001). The minimal important difference was met at cycle 12 (5.6 points) and approached at cycle 18 (4.8 points). There was no difference between groups for the other prespecified subscales from ASPIRE. A higher proportion of KRd patients met the GHS/QoL responder definition (≥ 5-point improvement) with statistical differences at cycle 12 (KRd v Rd patients, 25.5% v 17.4%, respectively) and 18 (KRd v Rd patients, 24.2% v 12.9%, respectively). Conclusion KRd improves GHS/QoL without negatively affecting patient-reported symptoms when compared with Rd. These data further support the benefit of KRd in patients with relapsed multiple myeloma. © 2016 by American Society of Clinical Oncology.
Stewart AK, Dimopoulos MA, Masszi T, Špička I, Oriol A, Hájek R, Rosiñol L, Siegel DS, Niesvizky R, Jakubowiak AJ, et al. Health-related quality-of-life results from the open-label, randomized, phase III ASPIRE trial evaluating carfilzomib, lenalidomide, and dexamethasone versus lenalidomide and dexamethasone in patientswith relapsed multiple myeloma. Journal of Clinical Oncology [Internet]. 2016;34(32):3921 - 3930. WebsiteAbstract
Purpose To determine the effects of carfilzomib, lenalidomide, and dexamethasone (KRd) versus lenalidomide and dexamethasone (Rd) on health-related quality of life (HR-QoL) in the Carfilzomib, Lenalidomide, and Dexamethasone Versus Lenalidomide and Dexamethasone for the Treatment of Patients With Relapsed Multiple Myeloma (ASPIRE) trial. Methods Patients with relapsed multiple myeloma were randomly assigned to receive KRd or Rd. The European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire C30 and myeloma-specific module were administered at baseline; day 1 of cycles 3, 6, 12, and 18; and after treatment. The Global Health Status/Quality of Life (GHS/QoL) scale and seven subscales (fatigue, nausea and vomiting, pain, physical functioning, role functioning, disease symptoms, and adverse effects of treatment) were compared between groups using a mixed model for repeated measures. The percentages of responders with ≥ 5- or 15-point GHS/QoL improvement at each cycle were compared between groups. Results Baseline questionnaire compliance was excellent (94.1% of randomly assigned patients). KRd patients had higher GHS/QoL scores versus Rd patients over 18 treatment cycles (two-sided P<.001). The minimal important difference was met at cycle 12 (5.6 points) and approached at cycle 18 (4.8 points). There was no difference between groups for the other prespecified subscales from ASPIRE. A higher proportion of KRd patients met the GHS/QoL responder definition (≥ 5-point improvement) with statistical differences at cycle 12 (KRd v Rd patients, 25.5% v 17.4%, respectively) and 18 (KRd v Rd patients, 24.2% v 12.9%, respectively). Conclusion KRd improves GHS/QoL without negatively affecting patient-reported symptoms when compared with Rd. These data further support the benefit of KRd in patients with relapsed multiple myeloma. © 2016 by American Society of Clinical Oncology.
Papaioannou TG, Karamanou M, Protogerou AD, Tousoulis D. Heat therapy: an ancient concept re-examined in the era of advanced biomedical technologies. Journal of Physiology [Internet]. 2016;594(23):7141 - 7142. Website
Ziogas DC, Kastritis E, Terpos E, Roussou M, Migkou M, Gavriatopoulou M, Spanomichou D, Eleutherakis-Papaiakovou E, Fotiou D, Panagiotidis I, et al. Hematologic and renal improvement of monoclonal immunoglobulin deposition disease after treatment with bortezomib-based regimens. Leukemia and Lymphoma [Internet]. 2016:1 - 8. WebsiteAbstract
Monoclonal immunoglobulin deposition disease (MIDD) is characterized by non-organized immunoglobulin-fragments along renal basement membranes with subsequent organ deterioration. Treatment is directed against the immunoglobulin-producing clone. We treated 18 MIDD patients with bortezomib-based regimens (12 received bortezomib-dexamethasone, 6 bortezomib-dexamethasone with cyclophosphamide). Eleven (61%) patients achieved a hematologic response, but only 6 (33.3%) reached to a complete (CR) or very good partial response (VGPR). Regarding renal outcomes 77.8 and 55.6% had ≥30 and ≥50% reduction of proteinuria, respectively, but 33.3% ended up in end-stage renal disease (ESRD). Among patients with CR or VGPR, median eGFR improvement was 7.7 ml/min/1.73 m2 and none progressed to ESRD, but no significant renal recovery was observed in patients achieving a partial response or less, with 50% progressing to dialysis. Pretreatment eGFR seems to influence renal prognosis. Bortezomib-based treatment is considered an effective approach in MIDD and reaching to a deep hematologic response (≥VGPR) conditionally controls further renal declining. © 2016 Informa UK Limited, trading as Taylor & Francis Group
Ziogas DC, Kastritis E, Terpos E, Roussou M, Migkou M, Gavriatopoulou M, Spanomichou D, Eleutherakis-Papaiakovou E, Fotiou D, Panagiotidis I, et al. Hematologic and renal improvement of monoclonal immunoglobulin deposition disease after treatment with bortezomib-based regimens. Leukemia and Lymphoma [Internet]. 2016:1 - 8. WebsiteAbstract
Monoclonal immunoglobulin deposition disease (MIDD) is characterized by non-organized immunoglobulin-fragments along renal basement membranes with subsequent organ deterioration. Treatment is directed against the immunoglobulin-producing clone. We treated 18 MIDD patients with bortezomib-based regimens (12 received bortezomib-dexamethasone, 6 bortezomib-dexamethasone with cyclophosphamide). Eleven (61%) patients achieved a hematologic response, but only 6 (33.3%) reached to a complete (CR) or very good partial response (VGPR). Regarding renal outcomes 77.8 and 55.6% had ≥30 and ≥50% reduction of proteinuria, respectively, but 33.3% ended up in end-stage renal disease (ESRD). Among patients with CR or VGPR, median eGFR improvement was 7.7 ml/min/1.73 m2 and none progressed to ESRD, but no significant renal recovery was observed in patients achieving a partial response or less, with 50% progressing to dialysis. Pretreatment eGFR seems to influence renal prognosis. Bortezomib-based treatment is considered an effective approach in MIDD and reaching to a deep hematologic response (≥VGPR) conditionally controls further renal declining. © 2016 Informa UK Limited, trading as Taylor & Francis Group
Paparizos P, Dimitriou D, Kenourgios D, Simos T. On high frequency dynamics between information asymmetry and volatility for securities. Journal of Economic Asymmetries [Internet]. 2016;13:21-34. Publisher's VersionAbstract
This paper investigates the relationship between the volatility of Volume Synchronized Probability of Informed Trading (VPIN) and future short-term volatility of stock returns. We construct a transaction-signed version of VPIN (TR-VPIN) based on tick by tick data on securities traded in the Athens Stock Exchange (ASE) during the Greek sovereign debt crisis. The results show a positive and statistically significant correlation between the volatility of TR-VPIN and future short-term volatility for securities that are exposed to asymmetric information during the period under examination. This evidence expands the existent literature which shows that the absolute order imbalance forecasts absolute returns, suggesting that TR-VPIN is a real-time informative indicator of the Probability of Informed Trading (PIN) in the high frequency domain. Further, the long-range dependence between the conditional volatilities of TR-VPIN and stock returns becomes more significant as we move towards securities which display stronger long memory. This is perfectly in line with the recent empirical evidence in microstructure literature that large past shocks of flow toxicity can lead to volatility through liquidity shortages.
Terpos E, Christoulas D, Kastritis E, Bagratuni T, Gavriatopoulou M, Roussou M, Papatheodorou A, Eleutherakis-Papaiakovou E, Kanellias N, Liakou C, et al. High levels of periostin correlate with increased fracture rate, diffuse MRI pattern, abnormal bone remodeling and advanced disease stage in patients with newly diagnosed symptomatic multiple myeloma. Blood Cancer Journal [Internet]. 2016;6(10):e482. WebsiteAbstract
Periostin is an extracellular matrix protein that is implicated in the biology of normal bone remodeling and in different cancer cell growth and metastasis. However, there is no information on the role of periostin in multiple myeloma (MM). Thus, we evaluated periostin in six myeloma cell lines in vitro; in the bone marrow plasma and serum of 105 newly diagnosed symptomatic MM (NDMM) patients and in the serum of 23 monoclonal gammopathy of undetermined significance (MGUS), 33 smoldering MM (SMM) patients, 30 patients at the plateau phase post-first-line therapy, 30 patients at first relapse and 30 healthy controls. We found high levels of periostin in the supernatants of myeloma cell lines compared with ovarian cancer cell lines that were not influenced by the incubation with the stromal cell line HS5. In NDMM patients the bone marrow plasma periostin was almost fourfold higher compared with the serum levels of periostin and correlated with the presence of fractures and of diffuse magnetic resonance imaging pattern of marrow infiltration. Serum periostin was elevated in NDMM patients compared with healthy controls, MGUS and SMM patients and correlated with advanced disease stage, high lactate dehydrogenase, increased activin-A, increased bone resorption and reduced bone formation. Patients at first relapse had also elevated periostin compared with healthy controls, MGUS and SMM patients, while even patients at the plateau phase had elevated serum periostin compared with healthy controls. These results support an important role of periostin in the biology of myeloma and reveal periostin as a possible target for the development of antimyeloma drugs. © 2016 The Author(s).
Terpos E, Christoulas D, Kastritis E, Bagratuni T, Gavriatopoulou M, Roussou M, Papatheodorou A, Eleutherakis-Papaiakovou E, Kanellias N, Liakou C, et al. High levels of periostin correlate with increased fracture rate, diffuse MRI pattern, abnormal bone remodeling and advanced disease stage in patients with newly diagnosed symptomatic multiple myeloma. Blood Cancer Journal [Internet]. 2016;6(10):e482. WebsiteAbstract
Periostin is an extracellular matrix protein that is implicated in the biology of normal bone remodeling and in different cancer cell growth and metastasis. However, there is no information on the role of periostin in multiple myeloma (MM). Thus, we evaluated periostin in six myeloma cell lines in vitro; in the bone marrow plasma and serum of 105 newly diagnosed symptomatic MM (NDMM) patients and in the serum of 23 monoclonal gammopathy of undetermined significance (MGUS), 33 smoldering MM (SMM) patients, 30 patients at the plateau phase post-first-line therapy, 30 patients at first relapse and 30 healthy controls. We found high levels of periostin in the supernatants of myeloma cell lines compared with ovarian cancer cell lines that were not influenced by the incubation with the stromal cell line HS5. In NDMM patients the bone marrow plasma periostin was almost fourfold higher compared with the serum levels of periostin and correlated with the presence of fractures and of diffuse magnetic resonance imaging pattern of marrow infiltration. Serum periostin was elevated in NDMM patients compared with healthy controls, MGUS and SMM patients and correlated with advanced disease stage, high lactate dehydrogenase, increased activin-A, increased bone resorption and reduced bone formation. Patients at first relapse had also elevated periostin compared with healthy controls, MGUS and SMM patients, while even patients at the plateau phase had elevated serum periostin compared with healthy controls. These results support an important role of periostin in the biology of myeloma and reveal periostin as a possible target for the development of antimyeloma drugs. © 2016 The Author(s).
Rapti S-M, Kontos CK, Papadopoulos IN, Scorilas A. High miR-96 levels in colorectal adenocarcinoma predict poor prognosis, particularly in patients without distant metastasis at the time of initial diagnosis. Tumor Biology. 2016;37:11815-11824.
Heylen H, De Rydt M, Neyens G, Bissell ML, Caceres L, Chevrier R, Daugas JM, Ichikawa Y, Ishibashi Y, Kamalou O, et al. High-precision quadrupole moment reveals significant intruder component in $_{13}^{33}\mathrm{Al}_{20}$ ground state. Phys. Rev. C. 2016;94:034312.
Tsoucalas G, Chevallier J, Karamanou M, Papaioannou T, Sgantzos M, Androutsos G. Historical hallmarks of anticoagulation and antiplatelet agents. Current Pharmaceutical Design [Internet]. 2016;22(13):1857 - 1861. Website
Triantaphyllou, M., Gogou, A., Dimiza, M., Kostopoulou, S., Parinos, C., Roussakis, G., Geraga, M., Bouloubassi, I., Fleitmann, D., Zervakis, V., et al. Holocene Climate Optimum centennial-scale paleoceanography in the NE Aegean Sea (Mediterranean Sea). Geo-Marine Letters [Internet]. 2016;36:51-66. Publisher's VersionAbstract
Combined micropaleontological and geochemical analyses of the high-sedimentation gravity core M-4G provided new centennial-scale paleoceanographic data for sapropel S1 deposition in the NE Aegean Sea during the Holocene Climatic Optimum. Sapropel layer S1a (10.2–8.0 ka) was deposited in dysoxic to oxic bottom waters characterized by a high abundance of benthic foraminiferal species tolerating surface sediment and/or pore water oxygen depletion (e.g.,Chilostomella mediterranensis, Globobulimina affinis), and the presence of Uvigerina mediterranea, which thrives in oxic mesotrophic-eutrophic environments. Preservation of organic matter (OM) is inferred based on high organic carbon as well as loliolide and isololiolide contents, while the biomarker record and the abundances of eutrophic planktonic foraminifera document enhanced productivity. High inputs of terrigenous OM are attributed to north Aegean borderland riverine inputs. Both alkenone-based sea surface temperatures (SSTs) and δO18 G. bulloides records indicate cooling at 8.2 ka (S1a) and ~7.8 ka (S1 interruption). Sapropelic layer S1b (7.7–6.4 ka) is characterized by rather oxic conditions; abundances of foraminiferal species tolerant to oxygen depletion are very low compared with the U. mediterranea rise. Strongly fluctuating SSTs demonstrate repeated cooling and associated dense water formation, with a major event at 7.4 ka followed by cold spells at 7.0, 6.8, and 6.5 ka. The prominent rise of the carbon preference index within the S1b layer indicates the delivery of less degraded terrestrial OM. The increase of algal biomarkers, labile OM-feeding foraminifera and eutrophic planktonic species pinpoints an enhanced in situ marine productivity, promoted by more efficient vertical convection due to repeated cold events. The associated contributions of labile marine OM along with fresher terrestrial OM inputs after ~7.7 ka imply sources alternative/additional to the north Aegean riverine borderland sources for the influx of organic matter in the south Limnos Basin, plausibly related to the inflow of highly productive Marmara/Black Sea waters.
Triantaphyllou, M.  , Gogou, A., Dimiza, M., Kostopoulou, S.  , Parinos, C., Roussakis, G., Geraga, M., Bouloubassi, I., Fleitmann, D., Zervakis, V., et al. Holocene Climate Optimum centennial-scale paleoceanography in the NE Aegean Sea (Mediterranean Sea). Geo-Marine Letters [Internet]. 2016;36:51-66. Publisher's VersionAbstract
Combined micropaleontological and geochemical analyses of the high-sedimentation gravity core M-4G provided new centennial-scale paleoceanographic data for sapropel S1 deposition in the NE Aegean Sea during the Holocene Climatic Optimum. Sapropel layer S1a (10.2–8.0 ka) was deposited in dysoxic to oxic bottom waters characterized by a high abundance of benthic foraminiferal species tolerating surface sediment and/or pore water oxygen depletion (e.g.,Chilostomella mediterranensis, Globobulimina affinis), and the presence of Uvigerina mediterranea, which thrives in oxic mesotrophic-eutrophic environments. Preservation of organic matter (OM) is inferred based on high organic carbon as well as loliolide and isololiolide contents, while the biomarker record and the abundances of eutrophic planktonic foraminifera document enhanced productivity. High inputs of terrigenous OM are attributed to north Aegean borderland riverine inputs. Both alkenone-based sea surface temperatures (SSTs) and δO18 G. bulloides records indicate cooling at 8.2 ka (S1a) and ~7.8 ka (S1 interruption). Sapropelic layer S1b (7.7–6.4 ka) is characterized by rather oxic conditions; abundances of foraminiferal species tolerant to oxygen depletion are very low compared with the U. mediterranea rise. Strongly fluctuating SSTs demonstrate repeated cooling and associated dense water formation, with a major event at 7.4 ka followed by cold spells at 7.0, 6.8, and 6.5 ka. The prominent rise of the carbon preference index within the S1b layer indicates the delivery of less degraded terrestrial OM. The increase of algal biomarkers, labile OM-feeding foraminifera and eutrophic planktonic species pinpoints an enhanced in situ marine productivity, promoted by more efficient vertical convection due to repeated cold events. The associated contributions of labile marine OM along with fresher terrestrial OM inputs after ~7.7 ka imply sources alternative/additional to the north Aegean riverine borderland sources for the influx of organic matter in the south Limnos Basin, plausibly related to the inflow of highly productive Marmara/Black Sea waters.
Anoussis M, Katavolos A, Todorov IG. Ideals of the {F}ourier algebra, supports and harmonic operators. Math. Proc. Cambridge Philos. Soc. [Internet]. 2016;161:223–235. Website
Mina D, Sagonas K, Fragopoulou AF, Pafilis P, Skouroliakou A, Margaritis LH, Tsitsilonis OE, Valakos ED. Immune responses of a wall lizard to whole-body exposure to radiofrequency electromagnetic radiation. Int J Radiat Biol. 2016;92(3):162-8.Abstract
PURPOSE: During the last three decades, the number of devices that emit non-ionizing electromagnetic radiation (EMR) at the wireless communication spectrum has rapidly increased and possible effects on living organisms have become a major concern. The purpose of this study was to investigate the effects of radiofrequency EMR emitted by a widely used wireless communication device, namely the Digital Enhanced Communication Telephony (DECT) base, on the immune responses of the Aegean wall lizard (Podarcis erhardii). MATERIALS AND METHODS: Adult male lizards were exposed 24 h/day for 8 weeks to 1880-1900 MHz DECT base radiation at average electric field intensity of 3.2 V/m. Immune reactivity was assessed using the phytohemagglutinin (PHA) skin swelling and mixed lymphocyte reaction (MLR) tests. RESULTS: Our results revealed a noticeable suppression (approximately 45%) of inflammatory responses in EMR-exposed lizards compared to sham-exposed animals. T cell-mediated responses were marginally affected. CONCLUSION: Daily radiofrequency EMR exposure seems to affect, at least partially, the immunocompetence of the Aegean wall lizard.
Vavuranakis M, Papaioannou TG, Katsarou OA, Vrachatis DA, Sanidas EA, Siasos G, Kalogeras KI, Schizas D, Stefanadis CI, Tousoulis D. Impact of atherosclerotic plaque components and their distribution on stent deployment: An intravascular-ultrasound virtual histology observational study. Minerva Cardioangiologica [Internet]. 2016;64(5):507 - 516. Website
Papaioannou, C.D. SSPKLVJIF. Impact of different preservation treatments on lipids of the smooth clam Callista chione. International Journal of Food Science and Technology [Internet]. 2016;51:325-332. Website
Dimopoulos MA, Cheung MC, Roussel M, Liu T, Gamberi B, Kolb B, Derigs HG, Eom HS, Belhadj K, Lenain P, et al. Impact of renal impairment on outcomes with lenalidomide and dexamethasone treatment in the FIRST trial, a randomized, open-label phase 3 trial in transplant-ineligible patients with multiple myeloma. Haematologica [Internet]. 2016;101(3):363 - 370. WebsiteAbstract
Renal impairment is associated with poor prognosis in myeloma. This analysis of the pivotal phase 3 FIRST trial examined the impact of renally adapted dosing of lenalidomide and dexamethasone on outcomes of patients with different degrees of renal impairment. Transplant-ineligible patients not requiring dialysis were randomized 1:1:1 to receive continuous lenalidomide and dexamethasone until disease progression (n=535) or for 18 cycles (72 weeks; n=541), or melphalan, prednisone, and thalidomide for 12 cycles (72 weeks; n=547). Follow-up is ongoing. Patients were grouped by baseline creatinine clearance into no (≥ 80 mL/min [n=389]), mild (≥ 50 to < 80 mL/min [n=715]), moderate (≥ 30 to < 50 mL/min [n=372]), and severe impairment (< 30 mL/min [n=147]) subgroups. Continuous lenalidomide and dexamethasone therapy reduced the risk of progression or death in no, mild, and moderate renal impairment subgroups vs. melphalan, prednisone, and thalidomide therapy (HR = 0.67, 0.70, and 0.65, respectively). Overall survival benefits were observed with continuous lenalidomide and dexamethasone treatment vs.melphalan, prednisone, and thalidomide treatment in no or mild renal impairment subgroups. Renal function improved from baseline in 52.6% of lenalidomide and dexamethasone–treated patients. The safety profile of continuous lenalidomide and dexamethasone was consistent across renal subgroups, except for grade 3/4 anemia and rash, which increased with increasing severity of renal impairment. Continuous lenalidomide and dexamethasone treatment, with renally adapted lenalidomide dosing, was effective for most transplant-ineligible patients with myeloma and renal impairment. Trial registration: ClinicalTrials.gov (NCT00689936); EudraCT (2007- 004823-39). Funding: Intergroupe Francophone du Myélome and the Celgene Corporation. © 2016 Ferrata Storti Foundation.
Bleta A, Nastos PT, Kaminski U, Dietze V. Impacts of Coarse Atmospheric Particulate Matter Between 2.5 and 80 mu m on Respiratory Admissions in Heraklion, Crete Island, Greece. In: {Karacostas TS, Bais AF, Nastos PT} PERSPECTIVES ON ATMOSPHERIC SCIENCES. {PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS}: {Aristotle Univ Thessaloniki, Sch Phys, Lab Atmospher Phys; Aristotle Univ Thessaloniki, Sch Geol, Dept Meteorol & Climatol; Hellen Meteorol Soc; Mariolopoulos Kanaginis Fdn Environm Sci}; 2016. pp. 1117-1122.Abstract
{The goal of this study is to quantify the impact of airborne coarse particles between 2.5 and 80 mu m (PM2.5-PM80) on hospital admissions for respiratory diseases, acquired from the two main hospitals in Heraklion, Crete Island. The atmospheric coarse particles were collected in Heraklion city from November 18, 2011 to May 31, 2013, using the Sigma-2 passive sampler technique. Further, the Scanning Electron Microscopy (SEM), was utilized to identify the qualitative structure of PMs. On one hand, we applied Generalized Addictive Models (GAMS) in order to assess the impact of coarse particles on respiratory diseases. The findings of the analysis revealed that the highest estimates were 7.3 % (Cl: 1.00-1.01) and 7.1 % (Cl: 1.00-1.01) increases in weekly respiratory admissions associated with an increase of 10 mu g m(-3) with respect to coarse particles between 10 and 20 mu m, for men and women, respectively. On the other hand, using SEM technique, the PMs were identified by means of their chemical composition. It is worth noting the presence of Rutile (a mineral composed primarily by Titanium Dioxide), which was found in our samples with possible origin from Saharan desert, causing adverse respiratory problems.}
Sagonas K, Rota IA, Tsitsilonis OE, Pafilis P, Valakos ED. Infection risk dictates immunological divergence among populations in a Mediterranean lizard. J Evol Biol. 2016;29(9):1680-8.Abstract
The ability of vertebrates to evolve different defence strategies in response to varying parasitism regimes remains poorly understood. Hosts may adopt two different strategies to defend themselves against parasites: tolerance (hosts alleviate the negative fitness consequences of parasite infection) and resistance (hosts strengthen their immune response as parasite burden increases). Both strategies are effective, but fitness has been reported to decline faster in less-tolerant individuals. Here, we assessed the number of splenocytes and the cell-mediated response (proxies for resistance) and body condition (a proxy for tolerance) in four populations of a Greek endemic lizard (Podarcis gaigeae), each exposed to different infection risks (defined as the cumulative effect of parasite burden and duration of exposure). We anticipated that populations with heavy parasite burden would enhance the efficacy of their immune response (resistance) compared to lizards deriving from parasite-poor habitats. We also predicted that populations with longer exposure to parasites would be adopted and be more tolerant. Each factor (duration of exposure and parasite burden) had a distinct effect on the immune response, and thus, our results were rather complicated. Lizards with heavy parasite burden and aperiodic exposure demonstrated resistance, whereas lizards with heavy parasite burden and chronic exposure were more tolerant. Populations with low parasite burden and minimal exposure were more resistant. Our results suggest that the development of some immunological strategies may be differentiated under different infection risks, even within the same species.
Vasilakaki S, Barbayianni E, Magrioti V, Pastukhov O, Constantinou-Kokotou V, Huwiler A, Kokotos G. Inhibitors of secreted phospholipase A2 suppress the release of PGE2 in renal mesangial cells. Bioorganic and Medicinal Chemistry. 2016;24:3029-3034.Abstract
The upregulation of PGE2 by mesangial cells has been observed under chronic inflammation condition. In the present work, renal mesangial cells were stimulated to trigger a huge increase of PGE2 synthesis and were treated in the absence or presence of known PLA2 inhibitors. A variety of synthetic inhibitors, mainly developed in our labs, which are known to selectively inhibit each of GIVA cPLA2, GVIA iPLA2, and GIIA/GV sPLA2, were used as tools in this study. Synthetic sPLA2 inhibitors, such as GK115 (an amide derivative based on the non-natural amino acid (R)-γ-norleucine) as well as GK126 and GK241 (2-oxoamides based on the natural (S)-α-amino acid leucine and valine, respectively) presented an interesting effect on the suppression of PGE2 formation.
Vasylyeva TI, Friedman SR, Paraskevis D, Magiorkinis G. Integrating molecular epidemiology and social network analysis to study infectious diseases: Towards a socio-molecular era for public health. Infect Genet Evol. 2016;46:248-255.Abstract
The number of public health applications for molecular epidemiology and social network analysis has increased rapidly since the improvement in computational capacities and the development of new sequencing techniques. Currently, molecular epidemiology methods are used in a variety of settings: from infectious disease surveillance systems to the description of disease transmission pathways. The latter are of great epidemiological importance as they let us describe how a virus spreads in a community, make predictions for the further epidemic developments, and plan preventive interventions. Social network methods are used to understand how infections spread through communities and what the risk factors for this are, as well as in improved contact tracing and message-dissemination interventions. Research is needed on how to combine molecular and social network data as both include essential, but not fully sufficient information on infection transmission pathways. The main differences between the two data sources are that, firstly, social network data include uninfected individuals unlike the molecular data sampled only from infected network members. Thus, social network data include more detailed picture of a network and can improve inferences made from molecular data. Secondly, network data refer to the current state and interactions within the social network, while molecular data refer to the time points when transmissions happened, which might have happened years before the sampling date. As of today, there have been attempts to combine and compare the data obtained from the two sources. Even though there is no consensus on whether and how social and genetic data complement each other, this research might significantly improve our understanding of how viruses spread through communities.
Triantafyllou N, Armeni E, Christidi F, Rizos D, Kaparos G, Palaiologou A, Augoulea A, Alexandrou A, Zalonis I, Tzivgoulis G, et al. The intensity of menopausal symptoms is associated with episodic memory in postmenopausal women. Climacteric [Internet]. 2016;19:393-399. Website
Kamberidou I. Interacting, sharing and bonding: ‘notes of personal experience’ by nineteenth-century women travellers. Gender, Place & CultureGender, Place & Culture [Internet]. 2016;23(3):381 - 397. Publisher's VersionAbstract
Kamberidou I. Interacting, sharing and bonding: ‘notes of personal experience’ by nineteenth-century women travellers. Gender, Place and Culture - A Journal of Feminist Geography. 2016;23(17):381-397.Abstract
As early as the seventeenth century, women have been going from one corner of the world to the other recording their experiences and reasons for publishing. Exploring, working and residing in regions of the East considered ‘safe for dynamic men only’ (Smith 1887, Through Cyprus, Author of ‘Glimpses of Greek life and Scenery, etc’. London: Hurst and Blacket), western women interacted with the peoples of Ottoman society, enjoying their warm and generous hospitality. Their gender allowed them to study, learn and become experts in areas where men had no access: the Ottoman harems, women's daily life, social gatherings and celebrations. Western and eastern women discuss harem slavery, marriage, adultery, childbirth, abortion, divorce, religion and women's rights. In reconsulting primary sources and focusing on the writings of nineteenth-century British women in Asia Minor (Turkey), this article contributes additional evidence on women's alternative representations or less degrading gaze, while revealing a patriarchal system's domestic-social reality that was founded on the institution of slavery. In other words, it differs from other studies in spotlighting the accounts that are illustrative of the polyethnic synthesis of the Ottoman households, i.e. the discourse on the multiethnic harem slavery institution, which distinguished Ottoman society, so as to provide a bigger picture and inspire new discussions.
gender_place_and_culture.pdf
Alexandris S, Papadopoulos P, Sakellariou G, Steinhart M, Butt H-J, Floudas G. Interfacial Energy and Glass Temperature of Polymers Confined to Nanoporous Alumina. Macromolecules [Internet]. 2016;49(19):7400-7414. Publisher's VersionAbstract
We report on the effect of interfacial energy on the glass temperature, Tg, of several amorphous polymers with various glass temperatures and polymer/substrate interactions confined within self-ordered nanoporous alumina (AAO). The polymers studied include poly(phenylmethylsiloxane) (PMPS), poly(vinyl acetate) (PVAc), 1,4-polybutadiene (PB), oligostyrene (PS), and poly(dimethylsiloxane) (PDMS). The segmental dynamics and associated Tg’s are studied by means of dielectric spectroscopy. The interfacial energy for the polymer/substrate interface, γSL, is calculated with Young’s equation whereas the AAO membrane surface energy is obtained by measuring contact angles for several reference liquids. We find that interfacial energy plays a significant role in the segmental dynamics of polymers under confinement within AAO. There is a trend for a decreasing glass temperature relative to the bulk with increasing interfacial energy. PDMS exhibits the highest interfacial energy and the highest reduction in glass temperature within AAO. Other effects that may also contribute to changes in Tg are discussed.
Kumar S, Paiva B, Anderson KC, Durie B, Landgren O, Moreau P, Munshi N, Lonial S, Bladé J, Mateos M-V, et al. International Myeloma Working Group consensus criteria for response and minimal residual disease assessment in multiple myeloma. The Lancet Oncology [Internet]. 2016;17(8):e328 - e346. WebsiteAbstract
Treatment of multiple myeloma has substantially changed over the past decade with the introduction of several classes of new effective drugs that have greatly improved the rates and depth of response. Response criteria in multiple myeloma were developed to use serum and urine assessment of monoclonal proteins and bone marrow assessment (which is relatively insensitive). Given the high rates of complete response seen in patients with multiple myeloma with new treatment approaches, new response categories need to be defined that can identify responses that are deeper than those conventionally defined as complete response. Recent attempts have focused on the identification of residual tumour cells in the bone marrow using flow cytometry or gene sequencing. Furthermore, sensitive imaging techniques can be used to detect the presence of residual disease outside of the bone marrow. Combining these new methods, the International Myeloma Working Group has defined new response categories of minimal residual disease negativity, with or without imaging-based absence of extramedullary disease, to allow uniform reporting within and outside clinical trials. In this Review, we clarify several aspects of disease response assessment, along with endpoints for clinical trials, and highlight future directions for disease response assessments. © 2016 Elsevier Ltd
Kumar S, Paiva B, Anderson KC, Durie B, Landgren O, Moreau P, Munshi N, Lonial S, Bladé J, Mateos M-V, et al. International Myeloma Working Group consensus criteria for response and minimal residual disease assessment in multiple myeloma. The Lancet Oncology [Internet]. 2016;17(8):e328 - e346. WebsiteAbstract
Treatment of multiple myeloma has substantially changed over the past decade with the introduction of several classes of new effective drugs that have greatly improved the rates and depth of response. Response criteria in multiple myeloma were developed to use serum and urine assessment of monoclonal proteins and bone marrow assessment (which is relatively insensitive). Given the high rates of complete response seen in patients with multiple myeloma with new treatment approaches, new response categories need to be defined that can identify responses that are deeper than those conventionally defined as complete response. Recent attempts have focused on the identification of residual tumour cells in the bone marrow using flow cytometry or gene sequencing. Furthermore, sensitive imaging techniques can be used to detect the presence of residual disease outside of the bone marrow. Combining these new methods, the International Myeloma Working Group has defined new response categories of minimal residual disease negativity, with or without imaging-based absence of extramedullary disease, to allow uniform reporting within and outside clinical trials. In this Review, we clarify several aspects of disease response assessment, along with endpoints for clinical trials, and highlight future directions for disease response assessments. © 2016 Elsevier Ltd
Dimopoulos MA, Sonneveld P, Leung N, Merlini G, Ludwig H, Kastritis E, Goldschmidt H, Joshua D, Orlowski RZ, Powles R, et al. International Myeloma working group recommendations for the diagnosis and management of Myeloma-Related Renal Impairment. Journal of Clinical Oncology [Internet]. 2016;34(13):1544 - 1557. WebsiteAbstract
Purpose The aim of the International Myeloma Working Group was to develop practical recommendations for the diagnosis and management of multiple myeloma-related renal impairment (RI). Methods Recommendations were based on published data through December 2015, and were developed using the system developed by the Grading of Recommendation, Assessment, Development, and Evaluation Working Group. Recommendations All patients with myeloma at diagnosis and at disease assessment should have serum creatinine, estimated glomerular filtration rate, and electrolytes measurements as well as free light chain, if available, and urine electrophoresis of a sample from a 24-hour urine collection (grade A). The Chronic Kidney Disease Epidemiology Collaboration, preferably, or the Modification of Diet in Renal Disease formula should be used for the evaluation of estimated glomerular filtration rate in patients with stabilized serum creatinine (grade A). International Myeloma Working Group criteria for renal reversibility should be used (grade B). For themanagement of RI in patientswithmultiplemyeloma, high fluid intake is indicated along with antimyeloma therapy (grade B). The use of high-cutoff hemodialysis membranes in combination with antimyeloma therapy can be considered (grade B). Bortezomib-based regimens remain the cornerstone of the management of myeloma-related RI (grade A). High-dose dexamethasone should be administered at least for the first month of therapy (grade B). Thalidomide is effective in patients with myeloma with RI, and no dose modifications are needed (grade B). Lenalidomide is effective and safe, mainly in patients with mild to moderate RI (grade B); for patients with severe RI or on dialysis, lenalidomide should be given with closemonitoring for hematologic toxicity (grade B) with dose reduction as needed. High-dose therapy with autologous stem cell transplantation (with melphalan 100 mg/m2 to 140 mg/m2) is feasible in patients with RI (grade C). Carfilzomib can be safely administered to patients with creatinine clearance . 15 mL/min, whereas ixazomib in combination with lenalidomide and dexamethasone can be safely administered to patients with creatinine clearance . 30 mL/min (grade A). © 2016 by American Society of Clinical Oncology.
Dimopoulos MA, Sonneveld P, Leung N, Merlini G, Ludwig H, Kastritis E, Goldschmidt H, Joshua D, Orlowski RZ, Powles R, et al. International Myeloma working group recommendations for the diagnosis and management of Myeloma-Related Renal Impairment. Journal of Clinical Oncology [Internet]. 2016;34(13):1544 - 1557. WebsiteAbstract
Purpose The aim of the International Myeloma Working Group was to develop practical recommendations for the diagnosis and management of multiple myeloma-related renal impairment (RI). Methods Recommendations were based on published data through December 2015, and were developed using the system developed by the Grading of Recommendation, Assessment, Development, and Evaluation Working Group. Recommendations All patients with myeloma at diagnosis and at disease assessment should have serum creatinine, estimated glomerular filtration rate, and electrolytes measurements as well as free light chain, if available, and urine electrophoresis of a sample from a 24-hour urine collection (grade A). The Chronic Kidney Disease Epidemiology Collaboration, preferably, or the Modification of Diet in Renal Disease formula should be used for the evaluation of estimated glomerular filtration rate in patients with stabilized serum creatinine (grade A). International Myeloma Working Group criteria for renal reversibility should be used (grade B). For themanagement of RI in patientswithmultiplemyeloma, high fluid intake is indicated along with antimyeloma therapy (grade B). The use of high-cutoff hemodialysis membranes in combination with antimyeloma therapy can be considered (grade B). Bortezomib-based regimens remain the cornerstone of the management of myeloma-related RI (grade A). High-dose dexamethasone should be administered at least for the first month of therapy (grade B). Thalidomide is effective in patients with myeloma with RI, and no dose modifications are needed (grade B). Lenalidomide is effective and safe, mainly in patients with mild to moderate RI (grade B); for patients with severe RI or on dialysis, lenalidomide should be given with closemonitoring for hematologic toxicity (grade B) with dose reduction as needed. High-dose therapy with autologous stem cell transplantation (with melphalan 100 mg/m2 to 140 mg/m2) is feasible in patients with RI (grade C). Carfilzomib can be safely administered to patients with creatinine clearance . 15 mL/min, whereas ixazomib in combination with lenalidomide and dexamethasone can be safely administered to patients with creatinine clearance . 30 mL/min (grade A). © 2016 by American Society of Clinical Oncology.
Kritikou V. Interpretaciones acerca de las formas del poder en la novela Aluvión de Fuego de Óscar Cerruto. In: ΠΟΛΥΠΡΑΓΜΟΣΥΝΗ: Homenaje al Profesor Alfonso Martínez Díez. 1st ed. Madrid: Ediciones Clásicas; 2016. pp. 389-394. homenaje_amd.kritikou.formasdelpoder.aluvion_de_fuego.pdf
Methenitis S, Terzis G, Zaras N, Stasinaki A-N, Karandreas N. Intramuscular fiber conduction velocity, isometric force and explosive performance. J Hum Kinet. 2016;51:93-101.Abstract
Conduction of electrical signals along the surface of muscle fibers is acknowledged as an essential neuromuscular component which is linked with muscle force production. However, it remains unclear whether muscle fiber conduction velocity (MFCV) is also linked with explosive performance. The aim of the present study was to investigate the relationship between vastus lateralis MFCV and countermovement jumping performance, the rate of force development and maximum isometric force. Fifteen moderately-trained young females performed countermovement jumps as well as an isometric leg press test in order to determine the rate of force development and maximum isometric force. Vastus lateralis MFCV was measured with intramuscular microelectrodes at rest on a different occasion. Maximum MFCV was significantly correlated with maximum isometric force (r = 0.66, p < 0.01), nevertheless even closer with the leg press rate of force development at 100 ms, 150 ms, 200 ms, and 250 ms (r = 0.85, r = 0.89, r = 0.91, r = 0.92, respectively, p < 0.01). Similarly, mean MFCV and type II MFCV were better correlated with the rate of force development than with maximum isometric leg press force. Lower, but significant correlations were found between mean MFCV and countermovement jump power (r = 0.65, p < 0.01). These data suggest that muscle fiber conduction velocity is better linked with the rate of force development than with isometric force, perhaps because conduction velocity is higher in the larger and fastest muscle fibers which are recognized to contribute to explosive actions.
Arianoutsou M, Christopoulou A, Vassilakis E, Papanikolaou I, Farangitakis GP. Investigating the Role of Bedrock Geology on the Process of Post-Fire Vegetation Recovery: A Case Study from the Taygetos Mountain. In: 8th Panhellenic Conference of Ecology (HELECOS). Thessaloniki; 2016.Abstract
Fires of 2007 have consumed large areas of Black pine and Greek fir forests in Peloponnese, Euboea and Attica. Most studies that followed, focused on the natural regeneration potential or the need for reforestation. The current research aims at examining the role of geomorphology and lithology that govern the soil properties upon the post-fire vegetation recovery at the landscape level. A case study from Taygetos Mt, a large part of which was burned in 2007, is presented. Based on the interpretation of a high spatial and spectral resolution satellite image (WorldView-3, 4/2015), several GIS thematic layers have been created showing unburned and regenerated patches over various lithological types. A network of sites was selected for field sampling representing various combinations of the above. Data on vegetation cover and recovery of the main tree species were collected. Results prove the interrelationship between regeneration and species traits as well as the existence of unburned patches near the burned ones. Recovery seems to be controlled by the geology of the plots as it was found weaker in plots overlying carbonate, permeable, not easily erodible formations as compared to that observed over clastic, impermeable, erodible formations of schists, even for the same species. In conclusion, post-fire vegetation recovery at the landscape level seems to be a complex process controlled not only from species biology but also from the landscape features and its fire history.
Levesanos N, Liyanage WPR, Ferentinos E, Raptopoulos G, Paraskevopoulou P, Sanakis Y, Choudhury A, Stavropoulos P, Nath M, Kyritsis P. Investigating the Structural, Spectroscopic, and Electrochemical Properties of [Fe {(EPiPr2) 2N} 2](E= S, Se) and the Formation of Iron Selenides by Chemical Vapor Deposition. European Journal of Inorganic Chemistry. 2016;2016(34):5332-5339.
Kenourgios D, Nader N, Dimitriou D. Islamic financial markets and global crises: Contagion or decoupling. Economic Modelling [Internet]. 2016;57:36-46. WebsiteAbstract
This paper investigates the contagion effects of the global financial crisis (GFC) and Eurozone sovereign debt crisis (ESDC) on Islamic equity and bond markets. Using a sample of Islamic stock indices from various developed and emerging markets and the global Islamic stock and bond (sukuk) indices, we explore asymmetric conditional correlation dynamics across stable and crisis periods and across the two crises. The results fail to provide strong contagion evidence between conventional and Islamic equity and bond indices, supporting the decoupling hypothesis of the Islamic securities. Our findings imply that Islamic equities and bonds may provide a cushion against risk and instability, particularly in periods of turmoil. The small number of contagion cases mostly relates to the ESDC and developed Islamic stock indices. The findings also show that the Islamic emerging stock indices in the BRICS provide the most effective international portfolio diversification benefits compared to the Islamic developed indices.
Kritikou V. La muerte en "Nino", "Leonela" y "En la ciénaga" de Onelio Jorge Cardoso. In: Nuevas perspectivas en los cuentos de Onelio Jorge Cardoso. 1st ed. Madrid: Ediciones del Orto; 2016. pp. 23-31. kritikou-muerte-ojcardoso.pdf
Achalhi, M., Munch, Ph., Cornee, J.-J., Azdimousa, A., Melinte-Dobrinescu, M., Quillévéré, F., Drinia, H., Fauquette, S., Jiménez-Moreno, G., Merzeraud, G., et al. The late Miocene Mediterranean-Atlantic connections through the North Rifian Corridor: New insights from the Boudinar and Arbaa Taourirt basins (northeastern Rif, Morocco). Palaeogeography, Palaeoclimatology, Palaeoecology [Internet]. 2016;459:131-152. Publisher's Version
Mamoucha S, Fokialakis N, Christodoulakis NS. Leaf structure and histochemistry of Ficus carica (Moraceae), the fig tree. Flora: Morphology, Distribution, Functional Ecology of Plants [Internet]. 2016;218:24 - 34. WebsiteAbstract
Heavily "armed" with trichomes, the hypostomatic leaf of Ficus carica L. is investigated with light and scanning electron microscopy. Histochemical tests were also applied to trace the secondary matabolites produced in the leaf of this well known, Mediterranean tree with the delicious fruits. Numerous idioblasts with crystals, laticifers and sized lythocysts appear within the compact mesophyll. Protective trichomes are located on both surfaces while capitate secretive hairs and stomata appear only abaxially. Stomata, concerning their magnitude, can be assembled in three size-groups in which the arrangement of their parastomatal cells differs as well. Histochemical reactions proved positive only for alkaloids within the laticifers and phenolic compounds, especially for the condensed tannins accumulated within the vacuole of the epidermal cells of this simply constructed leaf with unique features among the Mediterranean herbs. Comparison of GC-MS and LC-HRMS spectra of different extracts of the nerves and, separately, the rest of the leaf, revealed that coumarines such as umbeliferone, psoralen, bergapten and xanthotoxol are probably biosynthetically produced within the nerve area where the highly differentiated, main secretive apparatus of the leaf (laticifers) resides. That is why, these metabolites, are absent from the extracts of the undifferentiated cells derived from in vitro cultures. © 2015 Elsevier GmbH.
Mamoucha S, Christodoulakis NS. Leaf tissue arrangement, preliminary phytochemical investigation and callus induction from the medicinal hemi-parasite Osyris alba L. International Journal of Pharmacognosy and Phytochemical Research [Internet]. 2016;8(9):1437 - 1443. WebsiteAbstract
Osyris alba is a dioecious shrub used in traditional medicine for its bioactive secondary metabolites. It is used for its antiparasitic, antimicrobial and anti-bleeding properties. In the present study the leaf tissue arrangement, histochemsitry and callus formation of Osyris alba L. were investigated. Leaves (fresh and fixed) were observed by light, polarized oight and electron microscopy. Fresh stem was also observed by light microscopy. The sub-cellular localization of secondary metabolites was detected. Furthermore, in vitro production of its secondary metabolite, by using cell cultures, was also preformed. The compact leaves are amphistomatic, with a single layer of epidermal cells and contain idioblasts cells with crystals. They react positively to histochemical reagents for the major groups of secondary metabolites. In the preliminary histochemical screening, in vitro cultured cells also gave positive results. In conclusion, the medicinal nature of the plant is attributed to its phytochemical profile. Plant cell culture technologies can be used for the production of its bioactive molecules. © 2016, International Journal of Pharmacognosy and Phytochemical Research. All rights reserved.
Zagouri F, Roussou M, Kastritis E, Gavriatopoulou M, Eleutherakis-Papaiakovou E, Kanellias N, Kalapanida D, Christoulas D, Migkou M, Terpos E, et al. Lenalidomide with low- or intermediate-dose dexamethasone in patients with relapsed or refractory myeloma. Leukemia and Lymphoma [Internet]. 2016;57(8):1776 - 1780. WebsiteAbstract
Abstract: To compare the outcomes of patients with relapsed or refractory multiple myeloma (RRMM) who were treated with lenalidomide combined with high versus low dose of dexamethasone. One hundred forty consecutive relapsed or refractory multiple myeloma (RRMM) patients who received lenalidomide with dexamethasone, in two consecutive time periods, were divided into two groups: group RD (70 consecutive patients in the first period) who received lenalidomide with intermediate doses of dexamethasone and group Rd (70 consecutive patients in the more recent period) who received lenalidomide with low-dose dexamethasone. 62% and 73% of patients who received RD and Rd (p = 0.148) achieved at least a partial response, accordingly. The median OS was 20 and 41 months for the RD and the Rd group, accordingly. In the multivariate analysis, Rd was associated with improved PFS. More patients treated with RD developed grade 3&4 neutropenia and fatigue. It seems that Rd is at least as effective as RD. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
Zagouri F, Roussou M, Kastritis E, Gavriatopoulou M, Eleutherakis-Papaiakovou E, Kanellias N, Kalapanida D, Christoulas D, Migkou M, Terpos E, et al. Lenalidomide with low- or intermediate-dose dexamethasone in patients with relapsed or refractory myeloma. Leukemia and Lymphoma [Internet]. 2016;57(8):1776 - 1780. WebsiteAbstract
Abstract: To compare the outcomes of patients with relapsed or refractory multiple myeloma (RRMM) who were treated with lenalidomide combined with high versus low dose of dexamethasone. One hundred forty consecutive relapsed or refractory multiple myeloma (RRMM) patients who received lenalidomide with dexamethasone, in two consecutive time periods, were divided into two groups: group RD (70 consecutive patients in the first period) who received lenalidomide with intermediate doses of dexamethasone and group Rd (70 consecutive patients in the more recent period) who received lenalidomide with low-dose dexamethasone. 62% and 73% of patients who received RD and Rd (p = 0.148) achieved at least a partial response, accordingly. The median OS was 20 and 41 months for the RD and the Rd group, accordingly. In the multivariate analysis, Rd was associated with improved PFS. More patients treated with RD developed grade 3&4 neutropenia and fatigue. It seems that Rd is at least as effective as RD. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
Kellici TF, Ntountaniotis D, Kritsi E, Zervou M, Zoumpoulakis P, Potamitis C, Durdagi S, Salmas RE, Ergun G, Gokdemir E, et al. Leveraging NMR and X-ray data of the free ligands to build better drugs targeting angiotensin II Type 1 G-Protein coupled receptor. Current Medicinal Chemistry [Internet]. 2016;23(1):36 - 59. Website
Dimiza M, Koukousioura O, Triantaphyllou M, Dermitzakis M. Live and dead benthic foraminiferal assemblages from coastal environments of the Aegean Sea (Greece): Distribution and diversity. Revue de Micropaléontologie [Internet]. 2016;59(1):19-32. Publisher's VersionAbstract
Benthic foraminiferal composition assemblages and their temporal changes, ecological indices and foraminiferal densities are used to compare three coastal environments with different physicogeographical features in the Aegean Sea (coastal environment of Avdira–Vistonikos Gulf and Kitros–Thermaikos Gulf and open lagoonal environment of Vravron–South Evoikos Gulf). Three main foraminiferal assemblages have been recognized: a) “Assemblage A”; high degree of similarity between living and dead foraminiferal species, dominated byAmmonia beccarii, Elphidium spp. and relatively abundant and diverse miliolids, b) “Assemblage B1”; intermediate degree of similarity between live and dead assemblages, characterized by highly-abundant and well-diversified foraminiferal assemblages including the algal symbiont bearing Peneroplis pertusus together withAmmonia tepida and several small epiphytic rotaliids and miliolids, and c) “Assemblage B2”; absence of living individuals, strongly dominated by the opportunistic species A. tepida. Our results suggest a good comparison between living and dead assemblages from different coastal environments in the Aegean Sea, however the prevailing environmental conditions (vegetation cover, hydrodynamics, fresh water influx) have a strong impact on the taphonomic processes.
Christaki M, Stournaras G, Nastos P, Mamasis N. The majestic Hadrianic aqueduct of the city of Athens. Global Nest Journal [Internet]. 2016;18:559-568. Website
Fotiou D, Dimopoulos MA, Kastritis E. Managing renal complications in multiple myeloma. Expert Review of Hematology [Internet]. 2016;9(9):839 - 850. WebsiteAbstract
Introduction: About 20–40% of patients with multiple myeloma (MM) will present with some degree of renal impairment (RI) and about 25% of patients will experience RI at later disease stages. Patients with MM and RI have poorer overall survival and are at higher risk of early death. Areas covered: The mechanisms of acute renal damage in MM are covered and the issues around diagnosis and renal evaluation response are discussed. The importance of optimal supportive care is stressed and the role and effectiveness of different anti-myeloma agents covered including the role of high cut-off hemodialysis, autologous stem cell transplantation and kidney transplant. Expert commentary: Outcomes of patients with RI and rates of renal recovery have improved with the use of novel anti-myeloma agents. Bortezomib-dexamethasone backbone regimes (±third agent) are the current first choice in newly diagnosed patients. In relapsed/refractory disease additional treatment options include newer novel agents. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
Fotiou D, Dimopoulos MA, Kastritis E. Managing renal complications in multiple myeloma. Expert Review of Hematology [Internet]. 2016;9(9):839 - 850. WebsiteAbstract
Introduction: About 20–40% of patients with multiple myeloma (MM) will present with some degree of renal impairment (RI) and about 25% of patients will experience RI at later disease stages. Patients with MM and RI have poorer overall survival and are at higher risk of early death. Areas covered: The mechanisms of acute renal damage in MM are covered and the issues around diagnosis and renal evaluation response are discussed. The importance of optimal supportive care is stressed and the role and effectiveness of different anti-myeloma agents covered including the role of high cut-off hemodialysis, autologous stem cell transplantation and kidney transplant. Expert commentary: Outcomes of patients with RI and rates of renal recovery have improved with the use of novel anti-myeloma agents. Bortezomib-dexamethasone backbone regimes (±third agent) are the current first choice in newly diagnosed patients. In relapsed/refractory disease additional treatment options include newer novel agents. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
Kellici TF, Chatziathanasiadou MV, Diamantis D, Chatzikonstantinou AV, Andreadelis I, Christodoulou E, Valsami G, Mavromoustakos T, Tzakos AG. Mapping the interactions and bioactivity of quercetin—(2-hydroxypropyl)-β-cyclodextrin complex. International Journal of Pharmaceutics [Internet]. 2016;511(1):303 - 311. Website
Papaioannou TG, Protogerou AD, Vavuranakis M, Tousoulis D. Mean Arterial Pressure Estimation by a Non-Traditional Formula and Fractional Pulse Pressure. Journal of the American College of Cardiology [Internet]. 2016;68(6):668 - 669. Website
Papaioannou TG, Protogerou AD, Vrachatis D, Konstantonis G, Aissopou E, Argyris A, Nasothimiou E, Gialafos EJ, Karamanou M, Tousoulis D, et al. Mean arterial pressure values calculated using seven different methods and their associations with target organ deterioration in a single-center study of 1878 individuals. Hypertension Research [Internet]. 2016;39(9):640 - 647. Website
Fotakis, C. TTLSMTPSZDTD. Metabolic and antioxidant profiles of herbal infusions and decoctions. Food Chemistry [Internet]. 2016. Website
Almpanis E, Pantazopoulos PA, Papanikolaou N, Yannopapas V, Stefanou N. Metal-nanoparticle arrays on a magnetic garnet film for tunable plasmon-enhnaced Faraday rotation. Journal of the Optical Society of America B. 2016;33(12):2609-2616.Abstract
We developed an extension of the layer-multiple-scattering method to photonic crystals comprising homogeneous layers of magneto-optical materials. The applicability of the method is demonstrated on a specific architecture of a magnetic garnet thin film coated with a square array of silver nanodisks, supported by a silica substrate. It is shown that enhanced Faraday rotation, driven by hybrid particle plasmon-film quasi-guided collective modes, can be achieved within selected regions of frequency, which can be tuned by properly choosing the geometric and material parameters involved. The results are analyzed in conjunction with numerical simulations by the finite-element method and a consistent interpretation of the underlying physics is provided. Our extended layer-multiple-scattering computational methodology provides a versatile framework for fast and accurate full electrodynamic calculations of magneto-optical structures, enabling physical insight.
Stergiou GS, Parati G, Vlachopoulos C, Achimastos A, Andreadis E, Asmar R, Avolio A, Benetos A, Bilo G, Boubouchairopoulou N, et al. Methodology and technology for peripheral and central blood pressure and blood pressure variability measurement: Current status and future directions - Position statement of the European Society of Hypertension Working Group on blood pressure monitoring a. Journal of Hypertension [Internet]. 2016;34(9):1665 - 1677. Website
Dalezios NR, Nastos PT. Milestones of the diachronic evolution of meteorology. International Journal of Global Environmental Issues [Internet]. 2016;15:49-69. Website
Nastos PT, Polychroni ID. Modeling and in situ measurements of biometeorological conditions in microenvironments within the Athens University Campus, Greece. International Journal of Biometeorology [Internet]. 2016;60:1463-1479. Website
Vallatou Μ, Mitsopoulos Ι, Mallinis G, Vassilakis Ε, Arianoutsou Μ. Modeling Spatial Fire Risk and Exposure to Important Habitats in Cephalonia Island. In: 8th Panhellenic Conference of Ecology (HELECOS). Thessaloniki; 2016.Abstract
Within this study we introducea framework for assessing spatial fire risk and exposure to three important habitat types in Cephalonia island, Greece.Existing maps were used for plot allocation in orderto measure several fuel parameters in representative natural fuel complexes for site-specific fuel models development, as well as for collecting training and validation points for satellite data classification. The spatial extent of the fuel types and the canopy cover were delineated using a Landsat 8 OLI image acquired on 23-7-2015and the Support Vector Machines-(SVMs) machine learning algorithm. Subsequently, The Minimum Travel Time (MTT) algorithm, as it is embedded in FlamMap spatial fire simulation software, was applied in order to assess critical fire behavior parameters and exposure of Cephalonia's habitats under three different meteorological and fuel moisture scenarios. The outputs of this study may be used as an application of quantitative and probabilistic risk assessment for habitats conservation planning, prioritization and management of high value natural and cultural resources.
Mylonas DS, Siettos CI, Evdokimidis I, Papanicolaou AC, Smyrnis N. Modular patterns of phase desynchronization networks during a simple visuomotor task. Brain topography. 2016;29:118–129.
Beloukas A, Psarris A, Giannelou P, Kostaki E, Hatzakis A, Paraskevis D. Molecular epidemiology of HIV-1 infection in Europe: An overview. Infect Genet Evol. 2016;46:180-189.Abstract
Human Immunodeficiency Virus type 1 (HIV-1) is characterised by vast genetic diversity. Globally circulating HIV-1 viruses are classified into distinct phylogenetic strains (subtypes, sub-subtypes) and several recombinant forms. Here we describe the characteristics and evolution of European HIV-1 epidemic over time through a review of published literature and updated queries of existing HIV-1 sequence databases. HIV-1 in Western and Central Europe was introduced in the early-1980s in the form of subtype B, which is still the predominant clade. However, in Eastern Europe (Former Soviet Union (FSU) countries and Russia) the predominant strain, introduced into Ukraine in the mid-1990s, is subtype A (A) with transmission mostly occurring in People Who Inject Drugs (PWID). In recent years, the epidemic is evolving towards a complex tapestry with an increase in the prevalence of non-B subtypes and recombinants in Western and Central Europe. Non-B epidemics are mainly associated with immigrants, heterosexuals and females but more recently, non-B clades have also spread amongst groups where non-B strains were previously absent - non-immigrant European populations and amongst men having sex with men (MSM). In some countries, non-B clades have spread amongst the native population, for example subtype G in Portugal and subtype A in Greece, Albania and Cyprus. Romania provides a unique case where sub-subtype F1 has predominated throughout the epidemic. In contrast, HIV-1 epidemic in FSU countries remains more homogeneous with Aclade predominating in all countries. The differences between the evolution of the Western epidemic and the Eastern epidemic may be attributable to differences in transmission risk behaviours, lifestyle and the patterns of human mobility. The study of HIV-1 epidemic diversity provides a useful tool by which we can understand the history of the pandemic in addition to allowing us to monitor the spread and growth of the epidemic over time.
Hetem DJ, Derde LPG, Empel J, Mroczkowska A, Orczykowska-Kotyna M, Kozińska A, Hryniewicz W, Goossens H, Bonten MJM. Molecular epidemiology of MRSA in 13 ICUs from eight European countries. J Antimicrob Chemother. 2016;71(1):45-52.Abstract
OBJECTIVES: The European epidemiology of MRSA is changing with the emergence of community-associated MRSA (CA-MRSA) and livestock-associated MRSA (LA-MRSA). In this study, we investigated the molecular epidemiology of MRSA during 2 years in 13 ICUs in France, Greece, Italy, Latvia, Luxemburg, Portugal, Slovenia and Spain. METHODS: Surveillance cultures for MRSA from nose and wounds were obtained on admission and twice weekly from all patients admitted to an ICU for ≥3 days. The first MRSA isolate per patient was genotyped in a central laboratory by MLST, spa typing, agr typing and SCCmec (sub)typing. Risk factors for patients with an unknown history of MRSA colonization were identified. RESULTS: Overall, 14 390 ICU patients were screened, of whom 8519 stayed in an ICU for ≥3 days. Overall MRSA admission prevalence was 3.9% and ranged from 1.0% to 7.0% for individual ICUs. Overall MRSA acquisition rate was 2.5/1000 patient days at risk and ranged from 0.2 to 8/1000 patient days at risk per ICU. In total, 557 putative MRSA isolates were submitted to the central laboratory for typing, of which 511 (92%) were confirmed as MRSA. Each country had a distinct epidemiology, with ST8-IVc (UK-EMRSA-2/-6, USA500) being most prevalent, especially in France and Spain, and detected in ICUs in five of eight countries. Seventeen (3%) and three (<1%) isolates were categorized as CA-MRSA and LA-MRSA, respectively. Risk factors for MRSA carriage on ICU admission were age >70 years and hospitalization within 1 year prior to ICU admission. CONCLUSIONS: The molecular epidemiology of MRSA in 13 European ICUs in eight countries was homogeneous within, but heterogeneous between, countries. CA-MRSA and LA-MRSA genotypes and Panton-Valentine leucocidin-producing isolates were detected sporadically.
Tserkezis C, Stefanou N, Wubs M, Mørtensen NA. Molecular fluorescence enhancement in plasmonic environments: Exploring the role of nonlocal effects. Nanoscale. 2016;8(40):17532-17541.Abstract
Molecular spontaneous emission and fluorescence depend strongly on the emitter local environment. Plasmonic nanoparticles provide excellent templates for tailoring fluorophore emission, as they exhibit potential for both fluorescence enhancement and quenching, depending on emitter positioning in the nanoparticle vicinity. Here we explore the influence of hitherto disregarded nonclassical effects on the description of emitter–plasmon hybrids, focusing on the roles of the metal nonlocal response and especially size-dependent plasmon damping. Through extensive modelling of metallic nanospheres and nanoshells coupled to dipole emitters, we show that within a purely classical description a remarkable fluorescence enhancement can be achieved. However, once departing from the local-response approximation, and particularly by implementing the recent generalised nonlocal optical response theory, which provides a more complete physical description combining electron convection and diffusion, we show that not only are fluorescence rates dramatically reduced compared to the predictions of the local description and the common hydrodynamic Drude model, but the optimum emitter–nanoparticle distance is also strongly affected. In this respect, experimental measurements of fluorescence, the theoretical description of which requires a precise concurrent evaluation of far- and near-field properties of the system, constitute a novel, more sensitive probe for assessing the validity of state-of-the-art nonclassical theories.
Methenitis S, Karandreas N, Spengos K, Zaras N, Stasinaki A-N, Terzis G. Muscle Fiber Conduction Velocity, Muscle Fiber Composition, and Power Performance. Med Sci Sports Exerc. 2016;48(9):1761-71.Abstract
PURPOSE: The aim of this study was to explore the relationship between muscle fiber conduction velocity (MFCV), fiber type composition, and power performance in participants with different training background. METHODS: Thirty-eight young males with different training background participated: sedentary (n = 10), endurance runners (n = 9), power trained (n = 10), and strength trained (n = 9). They performed maximal countermovement jumps (CMJ) and maximal isometric leg press for the measurement of the rate of force development (RFD). Resting vastus lateralis MFCV was measured with intramuscular microelectrodes on a different occasion, whereas muscle fiber type and cross-sectional area (CSA) of vastus lateralis were evaluated through muscle biopsies 1wk later. RESULTS: MFCV, CMJ power, RFD, and % CSA of type II and type IIx fibers were higher for the power-trained group (P < 0.001). No difference was found between sedentary participants and endurance runners in these variables, but both of these groups performed worse than strength/power participants. Close correlations were found between MFCV and fiber CSA as well as the % CSA of all fiber types as well as with RFD and CMJ power (r = 0.712-0.943, P < 0.005). Partial correlations revealed that the % CSA of IIx fibers dictates a large part of the correlation between MFCV and RFD, power performance. Significant models for the prediction of the % CSA of type IIa and type II as well as the CSA of all muscle fibers based upon MFCV, RFD, and CMJ were revealed (P = 0.000). CONCLUSION: MFCV is closely associated with muscle fiber % CSA. RFD and jumping power are associated with the propagation of the action potentials along the muscle fibers. This link is regulated by the size and the distribution of type II, and especially type IIx muscle fibers.
Nikolopoulos GK, Pavlitina E, Muth SQ, Schneider J, Psichogiou M, Williams LD, Paraskevis D, Sypsa V, Magiorkinis G, Smyrnov P, et al. A network intervention that locates and intervenes with recently HIV-infected persons: The Transmission Reduction Intervention Project (TRIP). Sci Rep. 2016;6:38100.Abstract
Early treatment, soon after infection, reduces HIV transmissions and benefits patients. The Transmission Reduction Intervention Project (TRIP) evaluated a network intervention to detect individuals recently infected (in the past 6 months). TRIP was conducted in Greece (2013-2015) and focused on drug injector networks. Based on HIV status, testing history, and the results of an assay to detect recent infections, TRIP classified drug injector "Seeds" into groups: Recent Seeds (RS), and Control Seeds with Long-term HIV infection (LCS). The network members of RS and LCS were traced for two steps. The analysis included 23 RS, 171 network members of the RS, 19 LCS, and 65 network members of the LCS. The per-seed number of recents detected in the network of RS was 5 times the number in the network of LCS (Ratio RS vs. LCS: 5.23; 95% Confidence Interval (CI): 1.54-27.61). The proportion of recents among HIV positives in the network of RS (27%) was approximately 3 times (Ratio RS vs. LCS: 3.30; 95% CI: 1.04-10.43) that in the network of LCS (8%). Strategic network tracing that starts with recently infected persons could support public health efforts to find and treat people early in their HIV infection.
Papassotiriou G-P, Kastritis E, Gkotzamanidou M, Christoulas D, Eleutherakis-Papaiakovou E, Migkou M, Gavriatopoulou M, Roussou M, Margeli A, Papassotiriou I, et al. Neutrophil Gelatinase-Associated Lipocalin and Cystatin C Are Sensitive Markers of Renal Injury in Patients with Multiple Myeloma. Clinical Lymphoma, Myeloma and Leukemia [Internet]. 2016;16(1):29 - 35. WebsiteAbstract
Background Renal impairment is a common complication of patients with multiple myeloma (MM). We aimed to evaluate the clinical significance of 2 newly discovered biomarkers of renal injury, cystatin C (CysC), a protein reflecting glomerular filtration rate, and neutrophil gelatinase-associated lipocalin (NGAL), a protein reflecting tubular injuries. Patients and Methods We studied 64 patients with newly diagnosed myeloma: 16 with asymptomatic (smoldering) MM and 48 with symptomatic myeloma; 8 patients with monoclonal gammopathy of undetermined significance (MGUS); and 20 healthy control subjects. Along with common blood and urine chemistry determinations, measurements of CysC, NGAL, β2-microglobulin, high-sensitivity C-reactive protein, and interleukin 6 were performed. Results We found that only patients with symptomatic MM had increased levels of CysC compared to controls (P <.01); that serum NGAL levels were elevated in all patients compared to controls P <.001; that NGAL strongly correlated with both estimation of glomerular filtration rate (EGFR) (CysC) and EGFR (Modification of Diet in Renal Disease [MDRD] formula) (r = 0.616, P <.0001; and r = -0.371, P <.01, respectively); that CysC showed strong correlation with EGFR (r = -0.782, P <.001) and with the International Scoring System (ISS) (more pronounced in patients with ISS-3); and that receiver operating characteristic curve analysis showed that NGAL values of > 50.5 μg/L have a 80.8% sensitivity and 86.4% specificity for EGFR < 60 mL/min (area under the curve = 0.764). Conclusion These findings suggest that both NGAL and CysC are very sensitive markers that reflect renal impairment in newly diagnosed patients with MM. The high levels of NGAL in asymptomatic patients and in MGUS patients support the hypothesis of the presence of renal damage in these patients early in the course of their disease and may reveal NGAL to be an early marker that predicts the presence of renal impairment in MM. © 2016 Elsevier Inc.
Pefkianakis EK, Manthou VS, Paraskevopoulou P, Sakellariou G, Vougioukalakis GC. A New Family of Fullerene Derivatives Bearing Long Alkyl and Triethyleneglycol Moieties. ChemistrySelect. 2016;1(6):1232-1238.
Foscolos A-S, Papanastasiou I, Foscolos GB, Tsotinis A, Kellici TF, Mavromoustakos T, Taylor MC, Kelly JM. New hydrazones of 5-nitro-2-furaldehyde with adamantanealkanohydrazides: Synthesis and: In vitro trypanocidal activity. MedChemComm [Internet]. 2016;7(6):1229 - 1236. Website
Kontakiotis, G., Karakitsios, V., Mortyn, P.G., Antonarakou, A., Drinia, H., Anastasakis, G., Agiadi, K., Kafousia, N., De Rafelis, M. New insights into the early Pliocene hydrographic dynamics and their relationship to the climatic evolution of the Mediterranean Sea. Palaeogeography, Palaeoclimatology, Palaeoecology [Internet]. 2016;459:348-364. Publisher's Version
Matsangouras IT, Avgoustoglou E, Gofa F, Pytharoulis I, Nastos PT, Bluestein HW. Numerical Modeling Analysis of Tornadoes Using the COSMO.GR Model Over Greece. In: {Karacostas TS, Bais AF, Nastos PT} PERSPECTIVES ON ATMOSPHERIC SCIENCES. {PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS}: {Aristotle Univ Thessaloniki, Sch Phys, Lab Atmospher Phys; Aristotle Univ Thessaloniki, Sch Geol, Dept Meteorol & Climatol; Hellen Meteorol Soc; Mariolopoulos Kanaginis Fdn Environm Sci}; 2016. pp. 123-128.Abstract
{The COnsortium for Small-scale MOdeling (COSMO) was formed in October 1998, and its general goal is to develop, improve and maintain a non-hydrostatic limited-area atmospheric model, while the Hellenic National Meteorological Service joined the consortium in 1999. The COSMO model has been designed both for operational numerical weather prediction (NWP) as well as various scientific applications on the meso-beta and meso-c scale. Two tornado case studies were selected to investigate the ability of COSMO model to depict the characteristics of severe convective weather, which favored the development of the associated storms. The first tornado occurred, close to Ag. Ilias village, 8 km northwestern from Aitoliko city over western Greece on February 7, 2013, while the second tornado developed close to Palio Katramio village, 8 km southern from Xanthi city over northern Greece on November 25, 2015. Although both tornadoes had a short lifetime, they caused significant impacts. The COSMO. GR atmospheric model was initialized with analysis boundary conditions obtained from the European Centre for Medium-Range Weather Forecasts (ECMWF). The resulting numerical products with spatial resolution of 0.020 degrees (similar to 2 km) over the geographical domain of Greece depicted very well the severe convective conditions close to tornadoes formation.}
Mylonas MP, Nastos PT, Matsangouras IT. Numerical Modeling of a Tornado Event at Skala, Lakonia, Peloponnese in September 2015. In: {Karacostas TS, Bais AF, Nastos PT} PERSPECTIVES ON ATMOSPHERIC SCIENCES. {PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS}: {Aristotle Univ Thessaloniki, Sch Phys, Lab Atmospher Phys; Aristotle Univ Thessaloniki, Sch Geol, Dept Meteorol & Climatol; Hellen Meteorol Soc; Mariolopoulos Kanaginis Fdn Environm Sci}; 2016. pp. 81-86.Abstract
{Towards the evaluation of the thermodynamic characteristics of a high impact tornadic event in Skala Lakonia, southern Peloponnese, in September 21, 2015, Weather Research and Forecasting (AR-WRF) mesoscale model was used. For the particular model setup used in this study, different configurations were pre-tested based on different spatial resolution and parameterization schemes. The current study downscales ECMWF reanalysis initial and boundary conditions to 300 m spatial resolution to assess the convective available potential energy (CAPE), the reflectivity perceived by radar (dBZ) and the energy helicity index (EHI). The validation was conducted using in situ and remote sensing observations of the surrounding area. The results illustrate deep convective activity with CAPE values indicating a strong instability in the region of interest. Furthermore, the model seems to capture well the southwesterly-northeasterly front propagation of the convective initiation of the storm, as well as the troughs that affected the south part of Peloponnese, assessing the pre-frontal nature of the particular tornadic event. Finally, the EHI values demonstrate the tornadic activity in the region of Skala Lakonia, as the model appears to simulate accurately the low pressure system along the east coast of the Lakonia Gulf.}
Pytharoulis I, Matsangouras IT, Tegoulias I, Kotsopoulos S, Karacostas TS, Nastos PT. Numerical Study of the Medicane of November 2014. In: {Karacostas TS, Bais AF, Nastos PT} PERSPECTIVES ON ATMOSPHERIC SCIENCES. {PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS}: {Aristotle Univ Thessaloniki, Sch Phys, Lab Atmospher Phys; Aristotle Univ Thessaloniki, Sch Geol, Dept Meteorol & Climatol; Hellen Meteorol Soc; Mariolopoulos Kanaginis Fdn Environm Sci}; 2016. pp. 115-121.Abstract
{A hurricane-like cyclone with an `eye', eyewall convection and strong winds affected central Mediterranean basin on 7-8 November 2014. The maximum observed sustained wind speed was 22 m/s (tropical storm strength) at Lampedusa. Significant damages were reported from this island and the coastal regions of eastern Sicily. Thus, it is essential to study medicanes and calibrate the numerical weather prediction models in order to simulate them adequately. Operational ECMWF analyses are used together with the non-hydrostatic Weather Research and Forecasting numerical model with the Advanced Research dynamic solver (WRF-ARW ver 3.7.1). The aims of this study are to simulate the system and investigate the sensitivity of the model on the microphysical scheme, the number of vertical levels and the global input dataset. The main characteristics of the medicane are represented in good agreement with observations and analyses, but, no single setup is able to provide the best reproduction of all its features.}
Offers by Greek FL learners: A cross-sectional developmental study
Offers by Greek FL learners: A cross-sectional developmental study. Pragmatics [Internet]. 2016;26(4):531-562. Publisher's Version offers_by_greek_fl_learners.pdf
Mertzimekis TJ, Stamou K, Psaltis A. An online database of nuclear electromagnetic moments. Nucl. Instrum. Meth. Phys. Res. A. 2016;807:56–60.Abstract
Abstract Measurements of nuclear magnetic dipole and electric quadrupole moments are considered quite important for the understanding of nuclear structure both near and far from the valley of stability. The recent advent of radioactive beams has resulted in a plethora of new, continuously flowing, experimental data on nuclear structure – including nuclear moments – which hinders the information management. A new, dedicated, public and user friendly online database (http://magneticmoments.info) has been created comprising experimental data of nuclear electromagnetic moments. The present database supersedes existing printed compilations, including also non-evaluated series of data and relevant meta-data, while putting strong emphasis on bimonthly updates. The scope, features and extensions of the database are reported.
Bamias A, Tsantoulis P, Zilli T, Papatsoris A, Caparrotti F, Kyratsas C, Tzannis K, Stravodimos K, Chrisofos M, Wirth GJ, et al. Outcome of patients with nonmetastatic muscle-invasive bladder cancer not undergoing cystectomy after treatment with noncisplatin-based chemotherapy and/or radiotherapy: a retrospective analysis. Cancer Medicine [Internet]. 2016;5(6):1098 - 1107. WebsiteAbstract
Transurethral resection of bladder tumor (TURBT), radiotherapy, chemotherapy, or combinations can be used in patients with muscle-invasive bladder cancer (MIBC) not undergoing cystectomy. Nevertheless, unfitness for cystectomy is frequently associated with unfitness for other therapeutic modalities. We report the outcome of patients with MIBC who did not undergo cystectomy and did not receive cisplatin-based chemotherapy. Selection criteria for the study were nonmetastatic MIBC, no cystectomy, no cisplatin-based chemotherapy. Chemotherapy and/or radiotherapy should have been used aside from TURBT. Forty-nine patients (median age 79), managed between April 2001 and January 2012, were included in this analysis. Median Charlson Comorbidity Index was 5, while 76% were unfit for cisplatin. Treatment included radiotherapy (n = 7), carboplatin-based chemotherapy (n = 25), carboplatin-based chemotherapy followed by radiotherapy (n = 10), and radiochemotherapy (n = 7). Five-year event-free rate was 26% (standard error [SE] = 7) for overall survival, 23% (SE = 7) for progression-free survival, and 30 (SE = 8) for cancer-specific survival (CSS). Patients who were treated with combination of radiotherapy and chemotherapy had significantly longer CSS compared to those treated with radiotherapy or chemotherapy only (5-year CSS rate: 16% [SE 8] vs. 63% [SE 15], P = 0.053). Unfit-for-cystectomy patients frequently receive suboptimal nonsurgical treatment. Their outcome was poor. Combining chemotherapy with radiotherapy produced better outcomes and should be prospectively evaluated. © 2016 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
Bamias A, Tsantoulis P, Zilli T, Papatsoris A, Caparrotti F, Kyratsas C, Tzannis K, Stravodimos K, Chrisofos M, Wirth GJ, et al. Outcome of patients with nonmetastatic muscle-invasive bladder cancer not undergoing cystectomy after treatment with noncisplatin-based chemotherapy and/or radiotherapy: a retrospective analysis. Cancer Medicine [Internet]. 2016;5(6):1098 - 1107. WebsiteAbstract
Transurethral resection of bladder tumor (TURBT), radiotherapy, chemotherapy, or combinations can be used in patients with muscle-invasive bladder cancer (MIBC) not undergoing cystectomy. Nevertheless, unfitness for cystectomy is frequently associated with unfitness for other therapeutic modalities. We report the outcome of patients with MIBC who did not undergo cystectomy and did not receive cisplatin-based chemotherapy. Selection criteria for the study were nonmetastatic MIBC, no cystectomy, no cisplatin-based chemotherapy. Chemotherapy and/or radiotherapy should have been used aside from TURBT. Forty-nine patients (median age 79), managed between April 2001 and January 2012, were included in this analysis. Median Charlson Comorbidity Index was 5, while 76% were unfit for cisplatin. Treatment included radiotherapy (n = 7), carboplatin-based chemotherapy (n = 25), carboplatin-based chemotherapy followed by radiotherapy (n = 10), and radiochemotherapy (n = 7). Five-year event-free rate was 26% (standard error [SE] = 7) for overall survival, 23% (SE = 7) for progression-free survival, and 30 (SE = 8) for cancer-specific survival (CSS). Patients who were treated with combination of radiotherapy and chemotherapy had significantly longer CSS compared to those treated with radiotherapy or chemotherapy only (5-year CSS rate: 16% [SE 8] vs. 63% [SE 15], P = 0.053). Unfit-for-cystectomy patients frequently receive suboptimal nonsurgical treatment. Their outcome was poor. Combining chemotherapy with radiotherapy produced better outcomes and should be prospectively evaluated. © 2016 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
San-Miguel JF, Hungria VTM, Yoon S-S, Beksac M, Dimopoulos MA, Elghandour A, Jedrzejczak WW, Günther A, Nakorn TN, Siritanaratkul N, et al. Overall survival of patients with relapsed multiple myeloma treated with panobinostat or placebo plus bortezomib and dexamethasone (the PANORAMA 1 trial): a randomised, placebo-controlled, phase 3 trial. The Lancet Haematology [Internet]. 2016;3(11):e506 - e515. WebsiteAbstract
Background Panobinostat plus bortezomib and dexamethasone significantly increased median progression-free survival compared with placebo plus bortezomib and dexamethasone in the phase 3 PANORAMA 1 trial. Here, we present the final overall survival analysis for this trial. Methods PANORAMA 1 is a randomised, placebo-controlled, double-blind, phase 3 trial of patients with relapsed or relapsed and refractory multiple myeloma with one to three previous treatments. Patients were randomly assigned (1:1) to receive panobinostat (20 mg orally) or placebo, with bortezomib (1·3 mg/m2 intravenously) and dexamethasone (20 mg orally), over two distinct treatment phases. In treatment phase 1 (eight 3-week cycles), patients received: panobinostat or placebo on days 1, 3, 5, 8, 10, and 12; bortezomib on days 1, 4, 8, and 11; and dexamethasone on days 1, 2, 4, 5, 8, 9, 11, and 12. During treatment phase 2 (four 6-week cycles with a 2 weeks on, 1 week off schedule), panobinostat or placebo was given three times a week, bortezomib was administered once a week, and dexamethasone was given on the days of and following bortezomib administration. The primary endpoint was progression-free survival; overall survival was a key secondary endpoint. This study is registered at ClinicalTrials.gov, NCT01023308. Findings Between Jan 21, 2010, and Feb 29, 2012, 768 patients were enrolled into the study and randomly assigned to receive either panobinostat (n=387) or placebo (n=381), plus bortezomib and dexamethasone. At data cutoff (June 29, 2015), 415 patients had died. Median overall survival was 40·3 months (95% CI 35·0–44·8) in those who received panobinostat, bortezomib, and dexamethasone versus 35·8 months (29·0–40·6) in those who received placebo, bortezomib, and dexamethasone (hazard ratio [HR] 0·94, 95% CI 0·78–1·14; p=0·54). Of patients who had received at least two previous regimens including bortezomib and an immunomodulatory drug, median overall survival was 25·5 months (95% CI 19·6–34·3) in 73 patients who received panobinostat, bortezomib, and dexamethasone versus 19·5 months (14·1–32·5) in 74 who received placebo (HR 1·01, 95% CI 0·68–1·50). Interpretation The overall survival benefit with panobinostat over placebo with bortezomib and dexamethasone was modest. However, optimisation of the regimen could potentially prolong treatment duration and improve patients' outcomes, although further trials will be required to confirm this. Funding Novartis Pharmaceuticals. © 2016 Elsevier Ltd
San-Miguel JF, Hungria VTM, Yoon S-S, Beksac M, Dimopoulos MA, Elghandour A, Jedrzejczak WW, Günther A, Nakorn TN, Siritanaratkul N, et al. Overall survival of patients with relapsed multiple myeloma treated with panobinostat or placebo plus bortezomib and dexamethasone (the PANORAMA 1 trial): a randomised, placebo-controlled, phase 3 trial. The Lancet Haematology [Internet]. 2016;3(11):e506 - e515. WebsiteAbstract
Background Panobinostat plus bortezomib and dexamethasone significantly increased median progression-free survival compared with placebo plus bortezomib and dexamethasone in the phase 3 PANORAMA 1 trial. Here, we present the final overall survival analysis for this trial. Methods PANORAMA 1 is a randomised, placebo-controlled, double-blind, phase 3 trial of patients with relapsed or relapsed and refractory multiple myeloma with one to three previous treatments. Patients were randomly assigned (1:1) to receive panobinostat (20 mg orally) or placebo, with bortezomib (1·3 mg/m2 intravenously) and dexamethasone (20 mg orally), over two distinct treatment phases. In treatment phase 1 (eight 3-week cycles), patients received: panobinostat or placebo on days 1, 3, 5, 8, 10, and 12; bortezomib on days 1, 4, 8, and 11; and dexamethasone on days 1, 2, 4, 5, 8, 9, 11, and 12. During treatment phase 2 (four 6-week cycles with a 2 weeks on, 1 week off schedule), panobinostat or placebo was given three times a week, bortezomib was administered once a week, and dexamethasone was given on the days of and following bortezomib administration. The primary endpoint was progression-free survival; overall survival was a key secondary endpoint. This study is registered at ClinicalTrials.gov, NCT01023308. Findings Between Jan 21, 2010, and Feb 29, 2012, 768 patients were enrolled into the study and randomly assigned to receive either panobinostat (n=387) or placebo (n=381), plus bortezomib and dexamethasone. At data cutoff (June 29, 2015), 415 patients had died. Median overall survival was 40·3 months (95% CI 35·0–44·8) in those who received panobinostat, bortezomib, and dexamethasone versus 35·8 months (29·0–40·6) in those who received placebo, bortezomib, and dexamethasone (hazard ratio [HR] 0·94, 95% CI 0·78–1·14; p=0·54). Of patients who had received at least two previous regimens including bortezomib and an immunomodulatory drug, median overall survival was 25·5 months (95% CI 19·6–34·3) in 73 patients who received panobinostat, bortezomib, and dexamethasone versus 19·5 months (14·1–32·5) in 74 who received placebo (HR 1·01, 95% CI 0·68–1·50). Interpretation The overall survival benefit with panobinostat over placebo with bortezomib and dexamethasone was modest. However, optimisation of the regimen could potentially prolong treatment duration and improve patients' outcomes, although further trials will be required to confirm this. Funding Novartis Pharmaceuticals. © 2016 Elsevier Ltd
Nikolopoulos GK, Kostaki E-G, Paraskevis D. Overview of HIV molecular epidemiology among people who inject drugs in Europe and Asia. Infect Genet Evol. 2016;46:256-268.Abstract
HIV strains continuously evolve, tend to recombine, and new circulating variants are being discovered. Novel strains complicate efforts to develop a vaccine against HIV and may exhibit higher transmission efficiency and virulence, and elevated resistance to antiretroviral agents. The United Nations Joint Programme on HIV/AIDS (UNAIDS) set an ambitious goal to end HIV as a public health threat by 2030 through comprehensive strategies that include epidemiological input as the first step of the process. In this context, molecular epidemiology becomes invaluable as it captures trends in HIV evolution rates that shape epidemiological pictures across several geographical areas. This review briefly summarizes the molecular epidemiology of HIV among people who inject drugs (PWID) in Europe and Asia. Following high transmission rates of subtype G and CRF14_BG among PWID in Portugal and Spain, two European countries, Greece and Romania, experienced recent HIV outbreaks in PWID that consisted of multiple transmission clusters including subtypes B, A, F1, and recombinants CRF14_BG and CRF35_AD. The latter was first identified in Afghanistan. Russia, Ukraine, and other Former Soviet Union (FSU) states are still facing the devastating effects of epidemics in PWID produced by A(also known as IDU-A), B(known as IDU-B), and CRF03_AB. In Asia, CRF01_AE and subtype B (Western B and Thai B) travelled from PWID in Thailand to neighboring countries. Recombination hotspots in South China, Northern Myanmar, and Malaysia have been generating several intersubtype and inter-CRF recombinants (e.g. CRF07_BC, CRF08_BC, CRF33_01B etc.), increasing the complexity of HIV molecular patterns.
Hassinen S, Balis DS, Bauer H, Begoin M, Delcloo A, Eleftheratos K, Gimeno Garcia S, Granville J, Grossi M, Hao N, et al. Overview of the O3M SAF GOME-2 operational atmospheric composition and UV radiation data products and data availability. Atmospheric Measurement Techniques [Internet]. 2016;9:383-407. Publisher's Version a27_amt_2016.pdf
Kokotis P, Schmelz M, Kostouros E, Karandreas N, Dimopoulos M-A. Oxaliplatin-Induced Neuropathy: A Long-Term Clinical and Neurophysiologic Follow-Up Study. Clinical Colorectal Cancer [Internet]. 2016;15(3):e133 - e140. WebsiteAbstract
Micro-Abstract Acute oxaliplatin neurotoxicity and chronic sensory cumulative neuropathy were investigated in a long-term study of 31 consecutive patients with advanced colorectal cancer. Our results improve the knowledge of acute neurotoxicity and support the finding of the persistence of the sensory nerve deficits for years after the cessation of oxaliplatin therapy. © 2016 Elsevier Inc.
Kokotis P, Schmelz M, Kostouros E, Karandreas N, Dimopoulos M-A. Oxaliplatin-Induced Neuropathy: A Long-Term Clinical and Neurophysiologic Follow-Up Study. Clinical Colorectal Cancer [Internet]. 2016;15(3):e133 - e140. WebsiteAbstract
Micro-Abstract Acute oxaliplatin neurotoxicity and chronic sensory cumulative neuropathy were investigated in a long-term study of 31 consecutive patients with advanced colorectal cancer. Our results improve the knowledge of acute neurotoxicity and support the finding of the persistence of the sensory nerve deficits for years after the cessation of oxaliplatin therapy. © 2016 Elsevier Inc.
Πασιάς Γεώργιος, Φλουρής Γεώργιος, Φωτεινός Δημήτριος.

Παιδαγωγική και Εκπαίδευση

. 2nd ed. Athens, Greece: Γρηγόρης; 2016 pp. 704. Publisher's VersionAbstract
Ποιες είναι οι απαρχές των εκπαιδευτικών συστημάτων; Ποιες αρχές καθόρισαν τις «πειθαρχίες» και τη «γραμματική του σχολείου»; Πως διαγράφονται οι σχέσεις «εξουσίας-γνώσης» στο χώρο της εκπαίδευσης; Ποιες ιδέες επηρέασαν και διαμόρφωσαν τον παιδαγωγικό «λόγο» και τις εκπαιδευτικές «πρακτικές»; Ποιος είναι ο ρόλος της εκπαίδευσης στις σύγχρονες «οικονομίες και κοινωνίες της γνώσης»; Πώς καθορίζεται το σύγχρονο πλαίσιο των «ικανοτήτων» των μαθητών και των «προσόντων» των εκπαιδευτικών; Ποιοι είναι οι σύγχρονοι «λόγοι» και οι «πρακτικές» που χαρακτηρίζουν το σχολείο ως «οργανισμό και ως κοινότητα μάθησης»; Τα παραπάνω είναι μερικά από τα βασικά ερωτήματα που διατρέχουν τα κεφάλαια του παρόντος βιβλίου. Σκοπός των συγγραφέων είναι να αναλύσουν τη μετάβαση από την αρχαιολογία της εκπαίδευσης στη γενεαλογία του εκπαιδευτικού θεσμού. Στο βιβλίο παρουσιάζονται αναλυτικά θεωρήσεις και πολιτικές που επηρέασαν τη διαμόρφωση του παιδαγωγικού «λόγου» και των εκπαιδευτικών πρακτικών κατά τη διάρκεια του 19ου και του 20ου αιώνα. Έμφαση δίδεται στην ανάλυση των σχέσεων «εξουσίας-γνώσης» στο χώρο της εκπαίδευσης, και στις σχέσεις μεταξύ του εκπαιδευτικού «λόγου» και των κοινωνικών πρακτικών. Εξετάζονται οι επιδράσεις της «παγκοσμιοποίησης» και της «κοινωνίας της γνώσης» στον εκπαιδευτικό θεσμό. Αναλύονται οι σύγχρονες «πολιτικές της γνώσης» που συνδέονται με νέες θεωρίες και διαδικασίες μάθησης, με τη μετάβαση από το γνωσιοκεντρικό στο «ικανοκεντρικό» μοντέλο μάθησης, με τον μεταβαλλόμενο ρόλο και τις αλλαγές στα προσόντα των εκπαιδευτικών, με τον μετασχηματισμό του σχολείου σε «οργανισμό και σε κοινότητα μάθησης», με τη μετάβαση από τις «πειθαρχικές κοινωνίες» στις «κοινωνίες ελέγχου» και την προοπτική μιας ολοκληρωτικά παιδαγωγούμενης κοινωνίας. πάνω είναι μερικά από τα βασικά ερωτήματα που διατρέχουν τα κεφάλαια του παρόντος βιβλίου. Σκοπός των συγγραφέων είναι να αναλύσουν τη μετάβαση από την αρχαιολογία της εκπαίδευσης στη γενεαλογία του εκπαιδευτικού θεσμού. Στο βιβλίο παρουσιάζονται αναλυτικά θεωρήσεις και πολιτικές που επηρέασαν τη διαμόρφωση του παιδαγωγικού ≪λόγου≫ και των εκπαιδευτικών πρακτικών κατά τη διάρκεια του 19ου και του 20ου αιώνα. Έμφαση δίδεται στην ανάλυση των σχέσεων ≪εξουσίας-γνώσης≫ στο χώρο της εκπαίδευσης, και στις σχέσεις μεταξύ του εκπαιδευτικού ≪λόγου≫ και των κοινωνικών πρακτικών. Εξετάζονται οι επιδράσεις της ≪παγκοσμιοποίησης≫ και της ≪κοινωνίας της γνώσης≫ στον εκπαιδευτικό θεσμό. Αναλύονται οι σύγχρονες ≪πολιτικές της γνώσης≫ που συνδέονται με νέες θεωρίες και διαδικασίες μάθησης, με τη μετάβαση από το γνωσιοκεντρικό στο ≪ικανοκεντρικό≫ μοντέλο μάθησης, με τον μεταβαλλόμενο ρόλο και τις αλλαγές στα προσόντα των εκπαιδευτικών, με τον μετασχηματισμό του σχολείου σε ≪οργανισμό και σε κοινότητα μάθησης≫, με τη μετάβαση από τις ≪πειθαρχικές κοινωνίες≫ στις ≪κοινωνίες ελέγχου≫ και την προοπτική μιας ολοκληρωτικά παιδαγωγούμενης κοινωνίας. - See more at: http://www.grigorisbooks.gr/product/1718/%CF%80%CE%B1%CE%B9%CE%B4%CE%B1%CE%B3%CF%89%CE%B3%CE%B9%CE%BA%CE%AE-%CE%BA%CE%B1%CE%B9-%CE%B5%CE%BA%CF%80%CE%B1%CE%AF%CE%B4%CE%B5%CF%85%CF%83%CE%B7#sthash.1NcC0VDg.dpuf Ποιες είναι οι απαρχές των εκπαιδευτικών συστημάτων; Ποιες αρχές καθόρισαν τις ≪πειθαρχίες≫ και τη ≪γραμματική του σχολείου≫; Πως διαγράφονται οι σχέσεις ≪εξουσίας-γνώσης≫ στο χώρο της εκπαίδευσης; Ποιες ιδέες επηρέασαν και διαμόρφωσαν τον παιδαγωγικό ≪λόγο≫ και τις εκπαιδευτικές ≪πρακτικές≫; Ποιος είναι ο ρόλος της εκπαίδευσης στις σύγχρονες ≪οικονομίες και κοινωνίες της γνώσης≫; Πώς καθορίζεται το σύγχρονο πλαίσιο των ≪ικανοτήτων≫ των μαθητών και των ≪προσόντων≫ των εκπαιδευτικών; Ποιοι είναι οι σύγχρονοι ≪λόγοι≫ και οι ≪πρακτικές≫ που χαρακτηρίζουν το σχολείο ως ≪οργανισμό και ως κοινότητα μάθησης≫;  Τα παραπάνω είναι μερικά από τα βασικά ερωτήματα που διατρέχουν τα κεφάλαια του παρόντος βιβλίου. Σκοπός των συγγραφέων είναι να αναλύσουν τη μετάβαση από την αρχαιολογία της εκπαίδευσης στη γενεαλογία του εκπαιδευτικού θεσμού. Στο βιβλίο παρουσιάζονται αναλυτικά θεωρήσεις και πολιτικές που επηρέασαν τη διαμόρφωση του παιδαγωγικού ≪λόγου≫ και των εκπαιδευτικών πρακτικών κατά τη διάρκεια του 19ου και του 20ου αιώνα. Έμφαση δίδεται στην ανάλυση των σχέσεων ≪εξουσίας-γνώσης≫ στο χώρο της εκπαίδευσης, και στις σχέσεις μεταξύ του εκπαιδευτικού ≪λόγου≫ και των κοινωνικών πρακτικών. Εξετάζονται οι επιδράσεις της ≪παγκοσμιοποίησης≫ και της ≪κοινωνίας της γνώσης≫ στον εκπαιδευτικό θεσμό. Αναλύονται οι σύγχρονες ≪πολιτικές της γνώσης≫ που συνδέονται με νέες θεωρίες και διαδικασίες μάθησης, με τη μετάβαση από το γνωσιοκεντρικό στο ≪ικανοκεντρικό≫ μοντέλο μάθησης, με τον μεταβαλλόμενο ρόλο και τις αλλαγές στα προσόντα των εκπαιδευτικών, με τον μετασχηματισμό του σχολείου σε ≪οργανισμό και σε κοινότητα μάθησης≫, με τη μετάβαση από τις ≪πειθαρχικές κοινωνίες≫ στις ≪κοινωνίες ελέγχου≫ και την προοπτική μιας ολοκληρωτικά παιδαγωγούμενης κοινωνίας. - See more at: http://www.grigorisbooks.gr/product/1718/%CF%80%CE%B1%CE%B9%CE%B4%CE%B1%CE%B3%CF%89%CE%B3%CE%B9%CE%BA%CE%AE-%CE%BA%CE%B1%CE%B9-%CE%B5%CE%BA%CF%80%CE%B1%CE%AF%CE%B4%CE%B5%CF%85%CF%83%CE%B7#sthash.1NcC0VDg.dpuf
Richardson PG, Hungria VTM, Yoon S-S, Beksac M, Dimopoulos MA, Elghandour A, Jedrzejczak WW, Guenther A, Na Nakorn T, Siritanaratkul N, et al. Panobinostat plus bortezomib and dexamethasone in previously treated multiple myeloma: Outcomes by prior treatment. Blood [Internet]. 2016;127(6):713 - 721. WebsiteAbstract
Panobinostat is a potent pan-deacetylase inhibitor that affects the growth and survival of multiple myeloma (MM) cells through alteration of epigenetic mechanisms and protein metabolism. Panobinostat plus bortezomib and dexamethasone (PAN-BTZ-Dex) led to a significant increase in progression-free survival (PFS) vs placebo plus bortezomib and dexamethasone (Pbo-BTZ-Dex) in patients with relapsed or relapsed and refractoryMMin the phase 3PANORAMA1 trial. This subgroup analysis evaluated outcomes in patients in the PANORAMA 1 trial based on prior treatment: A prior immunomodulatory drug (IMiD; n 5 485), prior bortezomib plus an IMiD (n 5 193), and ≥2 prior regimens including bortezomib and an IMiD (n5147). Median PFS with PAN-BTZ-Dex vs Pbo-BTZ-Dex across subgroups was as follows: prior IMiD (12.3 vs 7.4 months; hazard ratio [HR], 0.54; 95% confidence interval [CI], 0.43-0.68), prior bortezomib plus IMiD (10.6 vs 5.8 months; HR, 0.52;95%CI, 0.36-0.76),and ≥2 prior regimens including bortezomib and an IMiD (12.5 vs 4.7 months; HR, 0.47; 95% CI, 0.31-0.72). Common grade 3/4 adverse events and laboratory abnormalities in patients who received PAN-BTZ-Dex across the prior treatment groups included thrombocytopenia, lymphopenia, neutropenia, diarrhea, and asthenia/ fatigue. Incidence of on-treatment deaths among patients who received prior bortezomib and an IMiD (regardless of number of prior regimens) was similar between treatment arms. This analysis demonstrated a clear PFS benefit of 7.8 months with PAN-BTZ-Dex among patients who received ‡2 prior regimens including bortezomib and an IMiD, a population with limited treatment options and poorer prognosis. This trial was registered at www.clinicaltrials.gov as #NCT01023308. © 2016 by The American Society of Hematology.
Richardson PG, Hungria VTM, Yoon S-S, Beksac M, Dimopoulos MA, Elghandour A, Jedrzejczak WW, Guenther A, Na Nakorn T, Siritanaratkul N, et al. Panobinostat plus bortezomib and dexamethasone in previously treated multiple myeloma: Outcomes by prior treatment. Blood [Internet]. 2016;127(6):713 - 721. WebsiteAbstract
Panobinostat is a potent pan-deacetylase inhibitor that affects the growth and survival of multiple myeloma (MM) cells through alteration of epigenetic mechanisms and protein metabolism. Panobinostat plus bortezomib and dexamethasone (PAN-BTZ-Dex) led to a significant increase in progression-free survival (PFS) vs placebo plus bortezomib and dexamethasone (Pbo-BTZ-Dex) in patients with relapsed or relapsed and refractoryMMin the phase 3PANORAMA1 trial. This subgroup analysis evaluated outcomes in patients in the PANORAMA 1 trial based on prior treatment: A prior immunomodulatory drug (IMiD; n 5 485), prior bortezomib plus an IMiD (n 5 193), and ≥2 prior regimens including bortezomib and an IMiD (n5147). Median PFS with PAN-BTZ-Dex vs Pbo-BTZ-Dex across subgroups was as follows: prior IMiD (12.3 vs 7.4 months; hazard ratio [HR], 0.54; 95% confidence interval [CI], 0.43-0.68), prior bortezomib plus IMiD (10.6 vs 5.8 months; HR, 0.52;95%CI, 0.36-0.76),and ≥2 prior regimens including bortezomib and an IMiD (12.5 vs 4.7 months; HR, 0.47; 95% CI, 0.31-0.72). Common grade 3/4 adverse events and laboratory abnormalities in patients who received PAN-BTZ-Dex across the prior treatment groups included thrombocytopenia, lymphopenia, neutropenia, diarrhea, and asthenia/ fatigue. Incidence of on-treatment deaths among patients who received prior bortezomib and an IMiD (regardless of number of prior regimens) was similar between treatment arms. This analysis demonstrated a clear PFS benefit of 7.8 months with PAN-BTZ-Dex among patients who received ‡2 prior regimens including bortezomib and an IMiD, a population with limited treatment options and poorer prognosis. This trial was registered at www.clinicaltrials.gov as #NCT01023308. © 2016 by The American Society of Hematology.
Καταπότη Δέσποινα, Βαβουρανάκης Γιώργος. Parthenon 2.0. In: Πετροπούλου Κρίστη, Ραμαντιέ Τιερί Αστικές γεωγραφίες: Τοπία και καθημερινές διαδρομές. Αθήνα: Εκδόσεις Καππόν; 2016. pp. 196-207.
Thodi G, Schulpis KH, Hatzidaki M, Molou E, Triantafylli O, Dotsikas Y, Loukas YL. Partial biotinidase deficiency: Identification of a single novel mutation (p.H314R) in a Greek newborn. Journal of Pediatric Endocrinology and Metabolism [Internet]. 2016;29:389-390. Website
Pafilis P, Lymberakis P, Sagonas K, Valakos E. The particularities of a remote islet shape the thermoregulatory profile of an endemic Mediterranean lizard. Journal of Thermal Biology. 2016;61:55-60.
Botonis PG, Toubekis AG, Terzis GD, Geladas ND, Platanou TI. Performance Decrement and Skill Deterioration During a Water Polo Game are Linked With the Conditioning Level of the Athletes. J Strength Cond Res. 2016;30(4):1033-41.Abstract
The aim of the study was to examine whether physical and technical performance deterioration after a water polo game is related to the athletes' conditioning level. Blood lactate concentration was measured during a 5 × 200-m incremental swimming test in 10 male water polo athletes to calculate the velocities corresponding to 4.0, 5.0, and 10.0 mmol·L lactate concentration (V4, V5, and V10, respectively) and define their conditioning level. All athletes participated in 5 competitive water polo games. Before (Pre), at half time (Mid), and after (Post) the first 2 games, handgrip strength and repeated sprint ability (8 × 20-m) were measured. Pre and Post the next 2 games, ball throwing velocity, shooting accuracy, and 400-m swim were evaluated. Pre, Mid, and Post the last game, the eggbeater kick test was performed. Handgrip strength, repeated sprint ability, 400-m swim performance, and ball shooting accuracy decreased after the game (8.4 ± 6.2%, 6.3 ± 3.4%, 7.0 ± 4.1%, and 20.3 ± 23.4%, respectively, p ≤ 0.05). V4, V5, and V10 were not significantly correlated with changes in physical or technical performance after the game. Performance in 400-m swim correlated with V4 and V5 whereas changes in 400-m swim Pre-Post, correlated with changes in ball shooting accuracy and throwing velocity (r = 0.73 and r = 0.80, p ≤ 0.05). These data suggest that V4, V5, and V10 may not correlate with performance decline in water polo. Interestingly, the 400-m swim test is connected with the decline in repeated sprints, ball shooting accuracy, and throwing velocity after a water polo game in well-trained athletes.
Vassilakopoulos TP, Pangalis GA, Chatziioannou S, Papageorgiou S, Angelopoulou MK, Galani Z, Kourti G, Prassopoulos V, Leonidopoulou T, Terpos E, et al. PET/CT in primary mediastinal large B-cell lymphoma responding to rituximab-CHOP: An analysis of 106 patients regarding prognostic significance and implications for subsequent radiotherapy. Leukemia [Internet]. 2016;30(1):238 - 242. Website
Gavriatopoulou M, Kastritis E, Kyrtsonis M-C, Vassilakopoulos TP, Roussou M, Fotiou D, Migkou M, Mpakiri M, Tasidou A, Terpos E, et al. Phase 2 study of ofatumumab, fludarabine and cyclophosphamide in relapsed/refractory Waldenström’s macroglobulinemia. Leukemia and Lymphoma [Internet]. 2016:1 - 3. Website
Gavriatopoulou M, Kastritis E, Kyrtsonis M-C, Vassilakopoulos TP, Roussou M, Fotiou D, Migkou M, Mpakiri M, Tasidou A, Terpos E, et al. Phase 2 study of ofatumumab, fludarabine and cyclophosphamide in relapsed/refractory Waldenström’s macroglobulinemia. Leukemia and Lymphoma [Internet]. 2016:1 - 3. Website
Zhao J, Sakellariou G, Green PF. Phase behavior of diblock copolymer/star-shaped polymer thin film mixtures. Soft Matter [Internet]. 2016;12:3849-3853. Publisher's VersionAbstract
We investigated the phase behavior of thin film, thickness h  100 nm, mixtures of a polystyrene-b-poly(2-vinylpyridine) (PS-b-P2VP) diblock copolymer with star-shaped polystyrene (SPS) molecules of varying functionalities f, where 4 < f < 64, and molecular weights per arm Marm. The miscibility of the system and the surface composition varied appreciably with Marm and f. For large values of Marm, regardless of f, the miscibility of the system was qualitatively similar to that of linear chain PS/PS-b-P2VP mixtures – the copolymer chains aggregate to form micelles, each composed of an inner P2VP core and PS corona, which preferentially segregate to the free surface. On the other hand, for large f and small Marm, SPS molecules preferentially resided at the free surface. Moreover, blends containing SPS molecules with the highest values of f and lowest values of Marm were phase separated. These observations are rationalized in terms of competing entropic interactions and the dependence of the surface tension of the star shaped molecules on Marm and f.
Protogerou AD, Aissopou EK, Argyris A, Nasothimiou EG, Konstantonis GD, Karamanou M, Papaioannou TG, Blacher J, Safar ME, Sfikakis PP. Phenotypes of office systolic blood pressure according to both brachial and aortic measurements: Frequencies and associations with carotid hypertrophy in 1861 adults. Journal of Hypertension [Internet]. 2016;34(7):1325 - 1330. Website
Alevizaki A, Sainidou R, Rembert P, Morvan B, Stefanou N. Phononic crystals of poroelastic spheres. Physical Review B. 2016;94(17):174306 (9 pages).Abstract
An extension of the layer-multiple-scattering method to phononic crystals of poroelastic spheres immersed in a fluid medium is developed. The applicability of the method is demonstrated on specific examples of close-packed fcc crystals of submerged water-saturated meso- and macroporous silica microspheres. It is shown that, by varying the pore size and/or the porosity, the transmission, reflection, and absorption spectra of finite slabs of these crystals are significantly altered. Strong absorption, driven by the slow waves in the poroelastic material and enhanced by multiple scattering, leads to negligible transmittance over an extended frequency range, which might be useful for practical applications in broadband acoustic shielding. The results are analyzed by reference to relevant phononic dispersion diagrams in the viscous and inertial coupling limits, and a consistent interpretation of the underlying physics is provided.
Chavrier D, Hovden J, Cazzoli S, Kamberidou I, Chroni S. Pioneers and outstanding women in national and international sports leadership. 2016. in_inspiratoinal_women_in_sport_book_cover.jpg inspirational_women_in_europe_making_a_difference_in_phys.ed_.sport_and_dance.pdf
Varytis P, Stefanou N. Plasmon-driven large Hall photon currents in light scattering by a core-shell magnetoplasmonic nanosphere. Journal of the Optical Society of America B. 2016;33(6):1286-1290.Abstract
The conditions for the occurrence of strong magnetotransverse anisotropy in light scattering by a single gyrotropic sphere are investigated by means of rigorous full electrodynamic multipole calculations. It is shown that composite magnetoplasmonic spherical scatterers with a core–shell morphology can induce large and tunable plasmon-driven Hall photon currents, which appear even in the case of subwavelength particles. Explicit results for silver-coated bismuth-substituted yttrium iron garnet nanospheres are presented and analyzed.
Sadori L, Koutsodendris A, Masi A, Bertini A, Combourieu-Nebout N, Franke A, Kouli K, Joannin S, Mercuri AM, Panagiotopoulos K, et al. Pollen-based paleoenvironmental and paleoclimatic changes at Lake Ohrid (SE Europe) during the past 500 ka. Biogeosciences [Internet]. 2016;13:1423-1437. Publisher's VersionAbstract
Lake Ohrid is located at the border between FYROM (Former Yugoslavian Republic of Macedonia) and Albania and formed during the latest phases of Alpine orogenesis. It is the deepest, the largest and the oldest tectonic lake in Europe. To better understand the paleoclimatic and paleoenvironmental evolution of Lake Ohrid, deep drilling was carried out in 2013 within the framework of the Scientific Collaboration on Past Speciation Conditions (SCOPSCO) project that was funded by the International Continental Scientific Drilling Program (ICDP). Preliminary results indicate that lacustrine sedimentation of Lake Ohrid started between 1.2 and 1.9 Ma ago. Here we present new pollen data (selected percentage and concentration taxa/groups) of the uppermost  ∼  200 m of the 569 m long DEEP core drilled in the depocentre of Lake Ohrid. The study is the fruit of a cooperative work carried out in several European palynological laboratories. The age model of this part of the core is based on 10 tephra layers and on tuning of biogeochemical proxy data to orbital parameters. According to the age model, the studied sequence covers the last  ∼  500 000 years at a millennial-scale resolution ( ∼  1.6 ka) and records the major vegetation and climate changes that occurred during the last 12 (13 only pro parte) marine isotope stages (MIS). Our results indicate that there is a general good correspondence between forested/non-forested periods and glacial–interglacial cycles of the marine isotope stratigraphy. The record shows a progressive change from cooler and wetter to warmer and drier interglacial conditions. This shift in temperature and moisture availability is visible also in vegetation during glacial periods. The period corresponding to MIS11 (pollen assemblage zone OD-10, 428–368 ka BP) is dominated by montane trees such as conifers. Mesophilous elements such as deciduous and semi-deciduous oaks dominate forest periods of MIS5 (PASZ OD-3, 129–70 ka BP) and MIS1 (PASZ OD-1, 14 ka BP to present). Moreover, MIS7 (PASZ OD-6, 245–190 ka) shows a very high interglacial variability, with alternating expansions of montane and mesophilous arboreal taxa. Grasslands (open vegetation formations requiring relatively humid conditions) characterize the earlier glacial phases of MIS12 (PASZ OD-12, 488–459 ka), MIS10 (corresponding to the central part of PASZ OD-10, 428–366 ka) and MIS8 (PASZ OD-7, 288–245 ka). Steppes (open vegetation formations typical of dry environments) prevail during MIS6 (OD-5 and OD-4, 190–129 ka) and during MIS4-2 (PASZ OD-2, 70–14 ka). Our palynological results support the notion that Lake Ohrid has been a refugium area for both temperate and montane trees during glacials. Closer comparisons with other long southern European and Near Eastern pollen records will be achieved through ongoing high-resolution studies.
Matekovits A, Dalamaga M, Stratigos A, Katsambas A, Antoniou C. Polymorphous light eruption under the Mediterranean sun: a clinico-epidemiological and photobiological study. Eur J Dermatol. 2016;26(3):304-6.
Siegel DS, Weisel KC, Dimopoulos MA, Baz R, Richardson P, Delforge M, Song KW, San Miguel JF, Moreau P, Goldschmidt H, et al. Pomalidomide plus low-dose dexamethasone in patients with relapsed/refractory multiple myeloma and moderate renal impairment: a pooled analysis of three clinical trials. Leukemia and Lymphoma [Internet]. 2016;57(12):2833 - 2838. WebsiteAbstract
Renal impairment (RI) is a major comorbidity in patients with multiple myeloma (MM). Here we present the pooled safety and efficacy analysis of three clinical trials (MM-002, MM-003, and MM-010) of pomalidomide + low-dose dexamethasone (POM + LoDEX) in patients with moderate RI (creatinine clearance [CrCl] ≥ 30 to <60 mL/min) and without RI (≥ 60 mL/min). Trial protocols were approved by the institutional review board of each site involved. Patients with RI were older than patients without RI, although other baseline characteristics were similar. The dosing and safety profile of POM + LoDEX was similar across RI subgroups. Median overall response rate, progression-free survival, time to progression, and duration of response were not significantly different between RI subgroups. However, patients with vs. without RI had significantly shorter median overall survival (10.5 vs. 14.0 months, respectively; p =.004). This analysis demonstrates that POM + LoDEX is a safe and effective treatment for patients with moderate RI. The trials were registered at ClinicalTrials.gov as NCT00833833 (MM-002), NCT01311687 (MM-003), and NCT01712789 (MM-010) and at EudraCT as 2010-019820-30 (MM-003) and 2012-001888-78 (MM-010). © 2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
Siegel DS, Weisel KC, Dimopoulos MA, Baz R, Richardson P, Delforge M, Song KW, San Miguel JF, Moreau P, Goldschmidt H, et al. Pomalidomide plus low-dose dexamethasone in patients with relapsed/refractory multiple myeloma and moderate renal impairment: a pooled analysis of three clinical trials. Leukemia and Lymphoma [Internet]. 2016;57(12):2833 - 2838. WebsiteAbstract
Renal impairment (RI) is a major comorbidity in patients with multiple myeloma (MM). Here we present the pooled safety and efficacy analysis of three clinical trials (MM-002, MM-003, and MM-010) of pomalidomide + low-dose dexamethasone (POM + LoDEX) in patients with moderate RI (creatinine clearance [CrCl] ≥ 30 to <60 mL/min) and without RI (≥ 60 mL/min). Trial protocols were approved by the institutional review board of each site involved. Patients with RI were older than patients without RI, although other baseline characteristics were similar. The dosing and safety profile of POM + LoDEX was similar across RI subgroups. Median overall response rate, progression-free survival, time to progression, and duration of response were not significantly different between RI subgroups. However, patients with vs. without RI had significantly shorter median overall survival (10.5 vs. 14.0 months, respectively; p =.004). This analysis demonstrates that POM + LoDEX is a safe and effective treatment for patients with moderate RI. The trials were registered at ClinicalTrials.gov as NCT00833833 (MM-002), NCT01311687 (MM-003), and NCT01712789 (MM-010) and at EudraCT as 2010-019820-30 (MM-003) and 2012-001888-78 (MM-010). © 2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
Ou Y, Doshi S, Nguyen A, Jonsson F, Aggarwal S, Rajangam K, Dimopoulos MA, Stewart AK, Badros A, Papadopoulos KP, et al. Population Pharmacokinetics and Exposure-Response Relationship of Carfilzomib in Patients With Multiple Myeloma. Journal of Clinical Pharmacology [Internet]. 2016. WebsiteAbstract
A population pharmacokinetic (PK) model and exposure-response (E-R) analysis was developed using data collected from 5 phase 1b/2 and 2 phase 3 studies in subjects with multiple myeloma. Subjects receiving intravenous infusion on 2 consecutive days each week for 3 weeks (days 1, 2, 8, 9, 15, and 16) in each cycle at doses ranging from 15 to 20/56 mg/m2 (20 mg/m2 in cycle 1 and, if tolerated, escalated to 56 mg/m2 on day 8 of cycle 1). The population PK analysis indicated that among all the covariates tested, the only statistically significant covariate was body surface area on carfilzomib clearance; however, this covariate was unlikely to be clinically significant. Despite inclusion of different populations (relapsed or relapsed/refractory), treatments (carfilzomib monotherapy or combination therapy), infusion lengths (2 to 10 minutes or 30 minutes), and different doses, the E-R analysis of efficacy showed that after adjusting for baseline characteristics, higher area under the concentration-time curve was associated with improved overall response rate (ORR), from 15 to 20/56 mg/m2. No positive relationships between maximum concentration and ORR were identified, indicating that ORR would not be expected to be impacted by infusion length. For safety end points, no statistically significant relationship between exposure and increasing risk of adverse events was identified. The results of an E-R analysis provided strong support for a carfilzomib dose at 20/56 mg/m2 as a 30-minute infusion for monotherapy and combination therapy. This article illustrates an example of application of E-R analysis to support labeling dose recommendation in the absence of extensive clinical data. © 2016, The American College of Clinical Pharmacology.
Lekkas E, Filis C, Andreadakis E, Skourtsos E, Diakakis M, Mavroulis S, Papaspyropoulos K, Alexoudi V, Kommatas M, Karalemas N, et al. Post-Fire Hazard and Risk Assessment in Fire-Affected Areas with GIS and Satellite Imagery: The Case of 2015 Laconia Forest Fire (Southeastern Peloponnese, Greece). In: Safe Greece - Safe Evros 2016. Alexandroupoli; 2016. pdfAbstract
On July 17, 2015 a forest fire that broke out in the southern part of Epidavros Limira peninsula (Laconia, southeastern Peloponnese), expanded rapidly due to strong winds blowing in the area and raged out of control for two days, inducing substantial damage to agriculture, livestock farming, buildings and infrastructure and causing one fatality. Innovative GIS-based methods were developed and implemented for the first time in a fire-affected area in Greece for mapping the post-fire erosion, flood and landslide hazards and risks. Geomorphological, geological, tectonic, hydrological, meteorological and land-use data along with a WorldView-2 satellite image and post-fire field observations were evaluated and used. A newly developed method was applied for assessing the erosion hazard. Analytic Hierarchy Process and Weighted Linear Combination methods were used for assessing the post-fire landslide susceptibility. The HEC-RAS model was used for hydraulic simulation and assessment of flood risk under post-fire conditions. Post-fire erosion, flood and landslide hazard and risk maps were constructed for the affected area delineating locations with very low, low, moderate, high or very high hazard and risk of erosion, flood and landslide respectively. The developed methodology is a useful post-fire hazard and risk assessment tool and can be applied by state authorities to assess the geo-environmental impact of fire disasters in areas with similar environmental conditions.
Vavouranakis G. A post-humanist approach to funerary ritual and its socio-historical significance: the Early and Middle Bronze tools tombs at Apesokari, Crete. In: Dakouri-Hild A, Boyd M Staging Death: Funerary Performance, Architecture and Landscape in the Aegean. Berlin: De Gruyter; 2016. pp. 253-273.
Moreau P, Van De Donk NWCJ, Miguel JS, Lokhorst H, Nahi H, Ben-Yehuda D, Cavo M, Cook G, Delforge M, Einsele H, et al. Practical Considerations for the Use of Daratumumab, a Novel CD38 Monoclonal Antibody, in Myeloma. Drugs [Internet]. 2016;76(8):853 - 867. WebsiteAbstract
Monoclonal antibodies (mAbs) are a recent addition to multiple myeloma (MM) therapies and a number of mAbs directed at myeloma cell surface molecules are in development. Daratumumab is a CD38 mAb that has demonstrated substantial activity and good tolerability in four phase I, phase I/II and phase II studies as monotherapy, as well as in combination with current standard treatments in MM. The positive results obtained in the relapsed/refractory setting in patients with advanced-stage disease and in a small number of patients with newly diagnosed disease provide the rationale for the investigation of the agent in a number of ongoing phase III trials. mAbs are generally better tolerated than conventional chemotherapy; however, their use requires other special considerations. Such factors include those common to all mAbs, namely infusion-related reactions, but also factors that are observed with mAbs used in myeloma, such as interference with response assessment, or factors that are related to CD38 mAbs such as daratumumab, for instance blood typing interference. Our review provides an overview of the results from the daratumumab clinical trials conducted to date, as well as practical management considerations for the use of daratumumab based on our experience with the agent. © 2016 Springer International Publishing Switzerland.
Moreau P, Van De Donk NWCJ, Miguel JS, Lokhorst H, Nahi H, Ben-Yehuda D, Cavo M, Cook G, Delforge M, Einsele H, et al. Practical Considerations for the Use of Daratumumab, a Novel CD38 Monoclonal Antibody, in Myeloma. Drugs [Internet]. 2016;76(8):853 - 867. WebsiteAbstract
Monoclonal antibodies (mAbs) are a recent addition to multiple myeloma (MM) therapies and a number of mAbs directed at myeloma cell surface molecules are in development. Daratumumab is a CD38 mAb that has demonstrated substantial activity and good tolerability in four phase I, phase I/II and phase II studies as monotherapy, as well as in combination with current standard treatments in MM. The positive results obtained in the relapsed/refractory setting in patients with advanced-stage disease and in a small number of patients with newly diagnosed disease provide the rationale for the investigation of the agent in a number of ongoing phase III trials. mAbs are generally better tolerated than conventional chemotherapy; however, their use requires other special considerations. Such factors include those common to all mAbs, namely infusion-related reactions, but also factors that are observed with mAbs used in myeloma, such as interference with response assessment, or factors that are related to CD38 mAbs such as daratumumab, for instance blood typing interference. Our review provides an overview of the results from the daratumumab clinical trials conducted to date, as well as practical management considerations for the use of daratumumab based on our experience with the agent. © 2016 Springer International Publishing Switzerland.
Mertzimekis TJ. Prediction and evaluation of magnetic moments in $T$=1/2, 3/2, and 5/2 mirror nuclei. Phys. Rev. C. 2016;94:064313.
Karampas GA, Eleftheriades MI, Panoulis KC, Rizou MD, Haliassos AD, Metallinou DK, Mastorakos GP, Rizos DA. Prediction of pre-eclampsia combining NGAL and other biochemical markers with Doppler in the first and/or second trimester of pregnancy. A pilot study. European Journal of Obstetrics Gynecology and Reproductive Biology [Internet]. 2016;205:153-157. Website
Nastos PT, Dalezios NR. Preface: Advances in meteorological hazards and extreme events. Natural Hazards and Earth System Sciences [Internet]. 2016;16:1259-1268. Website
Bizopoulos PA, Vavuranakis M, Papaioannou TG, Vrachatis DA, Sakellarios AI, Iliopoulou D, Tousoulis D, Koutsouris DD, Fotiadis DI. A preliminary study on In-Vivo 3-D imaging of Bioprosthetic Aortic Valve deformation. In: IFMBE Proceedings. Vol. 57. ; 2016. pp. 332 - 336. Website
Papadavid E, Katsimbri P, Kapniari I, Koumaki D, Karamparpa A, Dalamaga M, Tzannis K, Βoumpas D, Rigopoulos D. Prevalence of psoriatic arthritis and its correlates among patients with psoriasis in Greece: results from a large retrospective study. J Eur Acad Dermatol Venereol. 2016;30(10):1749-1752.Abstract
OBJECTIVES: To evaluate the prevalence and its clinical characteristics of psoriatic arthritis (PsA) in a specialized psoriasis clinic of a University Hospital. METHODS: In this retrospective study, 278 patients with psoriasis were evaluated between 2011 and 2013. RESULTS: The study included 278 patients with psoriasis: 144 (52%) were male and 134 (48%) female. Their median age was 51.41 with median psoriasis presenting age of 34.52 years. Referring to the type of psoriasis, 86% presented with plaque psoriasis, 5% guttate, 2% palms and soles, 2% inverse, 1% pustular and 4% with psoriasis of more than one type. Nail disease appeared in 121 patients (43.5%) and scalp disease in 175 (63%). Of these patients, 85 (30%) had PsA, whereas 51% of patients with PsA had psoriatic nail disease. With reference to the PsA type, 43 (51%) patients presented with polyarthritis, 10 (12%) with oligoarthritis, 7 (8%) with axial arthritis, whereas the rest 25 of them (31%) had PsA of more than one type. The subgroup of patients with PsA had significantly higher rates of comorbidities including arterial hypertension, diabetes and hypercholesterolaemia compared to non-PsA patients with 41% vs. 17% (P = 0.001), 20% vs. 8% (P = 0.021) and 41% vs. 19% (P = 0.004), respectively. CONCLUSION: The prevalence of PsA among patients with psoriasis was relatively higher in Greece compared to other ethnic-based studies. Comorbidities related to life expectancy were more frequent. As there is a high percentage of undiagnosed cases with active arthritis among patients with psoriasis, dermatologists should be aware of PsA clinical signs in order to recognize it earlier and provide successful treatment.
Cohen YC, Joffe E, Benyamini N, Dimopoulos MA, Terpos E, Trestman S, Held-Kuznetsov V, Avivi I, Kastritis E. Primary failure of bortezomib in newly diagnosed multiple myeloma-understanding the magnitude, predictors, and significance. Leukemia and Lymphoma [Internet]. 2016;57(6):1382 - 1388. WebsiteAbstract
Botezomib-based induction is highly effective for the treatment of newly diagnosed multiple myeloma (NDMM). We investigated the outcomes of NDMM patients who failed to respond to bortezomib-based induction in a real-life clinical setting. In a cohort of 295 consecutive NDMM patients in 3 medical centers, 74 (25%) failed to achieve at least partial response after 4 induction cycles, and were classified as non-responsive. Compared to induction responders, they were older, more frequently anemic, had a higher incidence of del17p and ISS-3, and a worse performance status. In multivariable analysis, bortezomib-based induction failure occurred in 25% of patients and was the strongest independent factor predicting mortality with a 5-fold hazard ratio (95% CI 1.44-8.68). Three-year overall survival in responsive vs. non-responsive patients were 76% vs. 53%, respectively (p < 0.0001). Survival from time of salvage second-line treatment was significantly shorter among induction non-responders vs. responders (25 months vs. not-reached, p = 0.024). © 2015 Taylor & Francis.
Cohen YC, Joffe E, Benyamini N, Dimopoulos MA, Terpos E, Trestman S, Held-Kuznetsov V, Avivi I, Kastritis E. Primary failure of bortezomib in newly diagnosed multiple myeloma-understanding the magnitude, predictors, and significance. Leukemia and Lymphoma [Internet]. 2016;57(6):1382 - 1388. WebsiteAbstract
Botezomib-based induction is highly effective for the treatment of newly diagnosed multiple myeloma (NDMM). We investigated the outcomes of NDMM patients who failed to respond to bortezomib-based induction in a real-life clinical setting. In a cohort of 295 consecutive NDMM patients in 3 medical centers, 74 (25%) failed to achieve at least partial response after 4 induction cycles, and were classified as non-responsive. Compared to induction responders, they were older, more frequently anemic, had a higher incidence of del17p and ISS-3, and a worse performance status. In multivariable analysis, bortezomib-based induction failure occurred in 25% of patients and was the strongest independent factor predicting mortality with a 5-fold hazard ratio (95% CI 1.44-8.68). Three-year overall survival in responsive vs. non-responsive patients were 76% vs. 53%, respectively (p < 0.0001). Survival from time of salvage second-line treatment was significantly shorter among induction non-responders vs. responders (25 months vs. not-reached, p = 0.024). © 2015 Taylor & Francis.
Foley BT, Leitner T, Paraskevis D, Peeters M. Primate immunodeficiency virus classification and nomenclature: Review. Infect Genet Evol. 2016;46:150-158.Abstract
The International Committee for the Taxonomy and Nomenclature of Viruses does not rule on virus classifications below the species level. The definition of species for viruses cannot be clearly defined for all types of viruses. The complex and interesting epidemiology of Human Immunodeficiency Viruses demands a detailed and informative nomenclature system, while at the same time it presents challenges such that many of the rules need to be flexibly applied or modified over time. This review outlines the nomenclature system for primate lentiviruses and provides an update on new findings since the last review was written in 2000.
Yui JC, Van Keer J, Weiss BM, Waxman AJ, Palmer MB, D'Agati VD, Kastritis E, Dimopoulos MA, Vij R, Bansal D, et al. Proteasome inhibitor associated thrombotic microangiopathy. American Journal of Hematology [Internet]. 2016;91(9):E348 - E352. WebsiteAbstract
A variety of medications have been implicated in the causation of thrombotic microangiopathy (TMA). Recently, a few case reports have emerged of TMA attributed to the proteasome inhibitors (PI) bortezomib and carfilzomib in patients with multiple myeloma. The aim of this case series was to better characterize the role of PI in the etiology of drug-induced TMA. We describe eleven patients from six medical centers from around the world who developed TMA while being treated with PI. The median time between medication initiation and diagnosis of TMA was 21 days (range 5 days to 17 months). Median laboratory values at diagnosis included hemoglobin—7.5 g dL−1, platelet count—20 × 109/L, LDH—698 U L−1, creatinine—3.12 mg dL−1. No patient had any other cause of TMA, including ADAMTS13 inhibition, other malignancy or use of any other medication previously associated with TMA. Nine patients had resolution of TMA without evidence of hemolysis after withdrawal of PI. Two patients had stabilization of laboratory values but persistent evidence of hemolysis despite medication withdrawal. One patient had recurrence of TMA with rechallenge of PI. There is a strong level of evidence that PI can cause DITMA. In evaluating patients with suspected TMA, PI use should be recognized as a potential etiology, and these medications should be discontinued promptly if thought to be the cause of TMA. Am. J. Hematol. 91:E348–E352, 2016. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.
Yui JC, Van Keer J, Weiss BM, Waxman AJ, Palmer MB, D'Agati VD, Kastritis E, Dimopoulos MA, Vij R, Bansal D, et al. Proteasome inhibitor associated thrombotic microangiopathy. American Journal of Hematology [Internet]. 2016;91(9):E348 - E352. WebsiteAbstract
A variety of medications have been implicated in the causation of thrombotic microangiopathy (TMA). Recently, a few case reports have emerged of TMA attributed to the proteasome inhibitors (PI) bortezomib and carfilzomib in patients with multiple myeloma. The aim of this case series was to better characterize the role of PI in the etiology of drug-induced TMA. We describe eleven patients from six medical centers from around the world who developed TMA while being treated with PI. The median time between medication initiation and diagnosis of TMA was 21 days (range 5 days to 17 months). Median laboratory values at diagnosis included hemoglobin—7.5 g dL−1, platelet count—20 × 109/L, LDH—698 U L−1, creatinine—3.12 mg dL−1. No patient had any other cause of TMA, including ADAMTS13 inhibition, other malignancy or use of any other medication previously associated with TMA. Nine patients had resolution of TMA without evidence of hemolysis after withdrawal of PI. Two patients had stabilization of laboratory values but persistent evidence of hemolysis despite medication withdrawal. One patient had recurrence of TMA with rechallenge of PI. There is a strong level of evidence that PI can cause DITMA. In evaluating patients with suspected TMA, PI use should be recognized as a potential etiology, and these medications should be discontinued promptly if thought to be the cause of TMA. Am. J. Hematol. 91:E348–E352, 2016. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.
Foivas A, Malenović A, Kostić N, Božić M, Knežević M, Loukas YL, Dotsikas Y. Quantitation of brinzolamide in dried blood spots by a novel LC-QTOF-MS/MS method. Journal of Pharmaceutical and Biomedical Analysis [Internet]. 2016;119:84-90. Website
Vrontaki E, Mavromoustakos T, Melagraki G, Afantitis A. Quantitative nanostructure-activity relationship models for the risk assessment of nanomaterials. In: Pharmaceutical Sciences: Breakthroughs in Research and Practice. Vol. 2. ; 2016. pp. 1314 - 1338. Website
Vrontaki E, Mavromoustakos T, Melagraki G, Afantitis A. Quantitative nanostructure-activity relationship models for the risk assessment of nanomaterials. In: Pharmaceutical Sciences: Breakthroughs in Research and Practice. Vol. 2. ; 2016. pp. 1314 - 1338. Website
Karamanou M, Tekiner H, Papaioannou TG, Konstantopoulos K, Androutsos G. Racial variation and cancer: A historical approach. Journal of B.U.ON. [Internet]. 2016;21(6):1568 - 1570. Website
Zaras ND, Stasinaki A-NE, Methenitis SK, Krase AA, Karampatsos GP, Georgiadis GV, Spengos KM, Terzis GD. Rate of Force Development, Muscle Architecture, and Performance in Young Competitive Track and Field Throwers. J Strength Cond Res. 2016;30(1):81-92.Abstract
The rate of force development (RFD) is an essential component for performance in explosive activities, although it has been proposed that muscle architectural characteristics might be linked with RFD and power performance. The purpose of the study was to investigate the relationship between RFD, muscle architecture, and performance in young track and field throwers. Twelve young track and field throwers completed 10 weeks of periodized training. Before (T1) and after (T2) training performance was evaluated in competitive track and field throws, commonly used shot put tests, isometric leg press RFD, 1 repetition maximum (1RM) strength as well as vastus lateralis architecture and body composition. Performance in competitive track and field throwing and the shot put test from the power position increased by 6.76 ± 4.31% (p < 0.001) and 3.58 ± 4.97% (p = 0.019), respectively. Rate of force development and 1RM strength also increased (p ≤ 0.05). Vastus lateralis thickness and fascicle length increased by 5.95 ± 7.13% (p = 0.012) and 13.41 ± 16.15% (p = 0.016), respectively. Significant correlations were found at T1 and T2, between performance in the shot put tests and both RFD and fascicle length (p ≤ 0.05). Close correlations were found between RFD, muscle thickness, and fascicle length (p ≤ 0.05). Significant correlations were found between the % changes in lean body mass and the % increases in RFD. When calculated together, the % increase in muscle thickness and RFD could predict the % increase in shot put throw test from the power position (p = 0.019). These results suggest that leg press RFD may predict performance in shot put tests that are commonly used by track and field throwers.
Kastritis E, Dimopoulos MA. Recent advances in the management of AL Amyloidosis. British Journal of Haematology [Internet]. 2016;172(2):170 - 186. WebsiteAbstract
Immunoglobulin light chain (AL) amyloidosis, the most common of the systemic amyloidosis, is characterized by the deposition of amyloid fibrils that derive from the aggregation of misfolded monoclonal immunoglobulin light chains. Amyloid fibrils disrupt tissue architecture and the pre-fibril oligomers are directly toxic to myocardiac cells, causing cardiac dysfunction. The lethal consequences of AL amyloidosis are due to the toxic product and not due to the malignant behaviour of the plasma cell clone however, the characteristics of this clone are associated with long-term prognosis. Early and accurate diagnosis is the key to effective management, but is challenging. Modern chemotherapy options (including autologous transplantation, bortezomib, lenalidomide) have improved the outcomes of patients at low or intermediate risk, but the prognosis of patients with severe cardiac dysfunction is still poor. Therapies targeting amyloid deposits and the amyloidogenic process are under investigation and offer promise for better future treatments. © 2016 John Wiley & Sons Ltd.
Castillo JJ, Garcia-Sanz R, Hatjiharissi E, Kyle RA, Leleu X, McMaster M, Merlini G, Minnema MC, Morra E, Owen RG, et al. Recommendations for the diagnosis and initial evaluation of patients with Waldenström Macroglobulinaemia: A Task Force from the 8th International Workshop on Waldenström Macroglobulinaemia. British Journal of Haematology [Internet]. 2016;175(1):77 - 86. WebsiteAbstract
The diagnosis of Waldenström macroglobulinaemia (WM) can be challenging given the variety of signs and symptoms patients can present. Furthermore, once the diagnosis of WM is established, the initial evaluation should be thorough as well as appropriately directed. During the 8th International Workshop for WM in London, United Kingdom, a multi-institutional task force was formed to develop consensus recommendations for the diagnosis and initial evaluation of patients with WM. In this document, we present the results of the deliberations that took place to address these issues. We provide recommendations for history-taking and physical examination, laboratory studies, bone marrow aspiration and biopsy analysis and imaging studies. We also provide guidance on the initial evaluation of special situations, such as anaemia, hyperviscosity, neuropathy, Bing-Neel syndrome and amyloidosis. We hope these recommendations serve as a practical guidance to clinicians taking care of patients with a suspected or an established diagnosis of WM. © 2016 John Wiley & Sons Ltd
Castillo JJ, Garcia-Sanz R, Hatjiharissi E, Kyle RA, Leleu X, McMaster M, Merlini G, Minnema MC, Morra E, Owen RG, et al. Recommendations for the diagnosis and initial evaluation of patients with Waldenström Macroglobulinaemia: A Task Force from the 8th International Workshop on Waldenström Macroglobulinaemia. British Journal of Haematology [Internet]. 2016;175(1):77 - 86. WebsiteAbstract
The diagnosis of Waldenström macroglobulinaemia (WM) can be challenging given the variety of signs and symptoms patients can present. Furthermore, once the diagnosis of WM is established, the initial evaluation should be thorough as well as appropriately directed. During the 8th International Workshop for WM in London, United Kingdom, a multi-institutional task force was formed to develop consensus recommendations for the diagnosis and initial evaluation of patients with WM. In this document, we present the results of the deliberations that took place to address these issues. We provide recommendations for history-taking and physical examination, laboratory studies, bone marrow aspiration and biopsy analysis and imaging studies. We also provide guidance on the initial evaluation of special situations, such as anaemia, hyperviscosity, neuropathy, Bing-Neel syndrome and amyloidosis. We hope these recommendations serve as a practical guidance to clinicians taking care of patients with a suspected or an established diagnosis of WM. © 2016 John Wiley & Sons Ltd
Vasylyeva TI, Friedman SR, Lourenco J, Gupta S, Hatzakis A, Pybus OG, Katzourakis A, Smyrnov P, Karamitros T, Paraskevis D, et al. Reducing HIV infection in people who inject drugs is impossible without targeting recently-infected subjects. AIDS. 2016;30(18):2885-2890.Abstract
OBJECTIVE: Although our understanding of viral transmission among people who inject drugs (PWID) has improved, we still know little about when and how many times each injector transmits HIV throughout the duration of infection. We describe HIV dynamics in PWID to evaluate which preventive strategies can be efficient. DESIGN: Due to the notably scarce interventions, HIV-1 spread explosively in Russia and Ukraine in 1990s. By studying this epidemic between 1995 and 2005, we characterized naturally occurring transmission dynamics of HIV among PWID. METHOD: We combined publicly available HIV pol and env sequences with prevalence estimates from Russia and Ukraine under an evolutionary epidemiology framework to characterize HIV transmissibility between PWID. We then constructed compartmental models to simulate HIV spread among PWID. RESULTS: In the absence of interventions, each injector transmits on average to 10 others. Half of the transmissions take place within 1 month after primary infection, suggesting that the epidemic will expand even after blocking all the post-first month transmissions. Primary prevention can realistically target the first month of infection, and we show that it is very efficient to control the spread of HIV-1 in PWID. Treating acutely infected on top of primary prevention is notably effective. CONCLUSION: As a large proportion of transmissions among PWID occur within 1 month after infection, reducing and delaying transmissions through scale-up of harm reduction programmes should always form the backbone of HIV control strategies in PWID. Growing PWID populations in the developing world, where primary prevention is scarce, constitutes a public health time bomb.
Moreau P, Weisel KC, Song KW, Gibson CJ, Saunders O, Sternas LA, Hong K, Zaki MH, Dimopoulos MA. Relationship of response and survival in patients with relapsed and refractory multiple myeloma treated with pomalidomide plus low-dose dexamethasone in the MM-003 trial randomized phase III trial (NIMBUS). Leukemia and Lymphoma [Internet]. 2016;57(12):2839 - 2847. WebsiteAbstract
Relapsed/refractory multiple myeloma (RRMM) patients have poor overall survival (OS). Pomalidomide plus low-dose dexamethasone (POM + LoDEX) significantly extends OS in RRMM vs. high-dose dexamethasone. Survival of patients with stable disease (SD) was compared to patients with progressive disease (PD) or ≥ partial response (≥PR) at cycles (C) 3, 5, and 7. Among 302 patients randomized to POM + LoDEX, at C3 19.2% achieved ≥ PR, 38.4% SD, and 14.6% PD. Patients with SD at C3 (17.4%) and C5 (13.6%) showed improved responses at C7. Median OS from randomization by response at C3 was 22.4 months for ≥ PR (n = 58, HR 0.66; 95% CI 0.40–1.08, p = 0.0976 vs. SD), 16.2 months for SD (n = 116), and 6.3 months for PD (n = 44, HR 3.43; 95% CI 2.23–5.27, p < 0.0001 vs. SD). Similar patterns were observed for C5 and C7. Results show that POM + LoDEX should be a standard treatment after lenalidomide and bortezomib, including in SD patients. © 2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
Moreau P, Weisel KC, Song KW, Gibson CJ, Saunders O, Sternas LA, Hong K, Zaki MH, Dimopoulos MA. Relationship of response and survival in patients with relapsed and refractory multiple myeloma treated with pomalidomide plus low-dose dexamethasone in the MM-003 trial randomized phase III trial (NIMBUS). Leukemia and Lymphoma [Internet]. 2016;57(12):2839 - 2847. WebsiteAbstract
Relapsed/refractory multiple myeloma (RRMM) patients have poor overall survival (OS). Pomalidomide plus low-dose dexamethasone (POM + LoDEX) significantly extends OS in RRMM vs. high-dose dexamethasone. Survival of patients with stable disease (SD) was compared to patients with progressive disease (PD) or ≥ partial response (≥PR) at cycles (C) 3, 5, and 7. Among 302 patients randomized to POM + LoDEX, at C3 19.2% achieved ≥ PR, 38.4% SD, and 14.6% PD. Patients with SD at C3 (17.4%) and C5 (13.6%) showed improved responses at C7. Median OS from randomization by response at C3 was 22.4 months for ≥ PR (n = 58, HR 0.66; 95% CI 0.40–1.08, p = 0.0976 vs. SD), 16.2 months for SD (n = 116), and 6.3 months for PD (n = 44, HR 3.43; 95% CI 2.23–5.27, p < 0.0001 vs. SD). Similar patterns were observed for C5 and C7. Results show that POM + LoDEX should be a standard treatment after lenalidomide and bortezomib, including in SD patients. © 2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
Papaioannou TG, Stamatelopoulos K, Tousoulis D. Repeatability of different segmental pulse wave velocity measurements. American Journal of Hypertension [Internet]. 2016;29(7):889. Website
Responding to thanks: divergence between native speakers and FL learners of Greek and the consequences for establishing rapport
Bella S. Responding to thanks: divergence between native speakers and FL learners of Greek and the consequences for establishing rapport. Glossologia [Internet]. 2016;24:61-73. Publisher's Version
Angelopoulou V, Kouvaris E, Lagaki V, Mertzimekis TJ, Papagiannis P. Resurrected from the dead: Full characterization of an old HPGe detector using γ-ray and CT tomographies coupled to standard calibration techniques and simulations. In: Hellenic Nuclear Physics Society; 2016.
Diémoz H, Eleftheratos K, Kazadzis S, Amiridis V, Zerefos CS. Retrieval of aerosol optical depth in the visible range with a Brewer spectrophotometer in Athens. Atmospheric Measurement Techniques [Internet]. 2016;9:1871-1888. Publisher's Version a29_amt_2016.pdf
Despotopoulou A. Review of Charlotte Mathieson, Mobility in the Victorian Novel: Placing the Nation. Journal of Transport History. 2016;37(2):272-274.
Despotopoulou A. Review of Martha Banta, Henry James: An "Alien's" History of America. Americana [Internet]. 2016;XII(2). Publisher's Version
Fotiou D, Gerotziafas G, Kastritis E, Dimopoulos MA, Terpos E. A review of the venous thrombotic issues associated with multiple myeloma. Expert Review of Hematology [Internet]. 2016;9(7):695 - 706. WebsiteAbstract
Introduction: Patients with multiple myeloma (MM) have an increased risk of venous thromboembolic (VTE) complications. The first reports of high VTE rates date back to 1999 but became more apparent with the introduction of novel agents in the treatment of MM and mostly with immunomodulatory drugs (IMiDs; thalidomide, lenalidomide and pomalidomide). Areas covered: Currently thromboprophylaxis is recommended for patients who receive IMiDs-based regimens and the type of thrombophrophylaxis is based on patient-, disease- and treatment-related risk factors. Making the distinction between the intrinsic risk of thrombosis in MM and the effect of therapy is crucial. The use of aspirin, low molecular weight heparins and warfarin are the recommended drugs but despite their appropriate use the rates of VTE are not completely eliminated. Expert commentary: Research into biomarkers of increased coagulability and their incorporation in risk assessment models could identify patients most likely to benefit from thromboprophylaxis but such models are not widely used in myeloma. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
Fotiou D, Gerotziafas G, Kastritis E, Dimopoulos MA, Terpos E. A review of the venous thrombotic issues associated with multiple myeloma. Expert Review of Hematology [Internet]. 2016;9(7):695 - 706. WebsiteAbstract
Introduction: Patients with multiple myeloma (MM) have an increased risk of venous thromboembolic (VTE) complications. The first reports of high VTE rates date back to 1999 but became more apparent with the introduction of novel agents in the treatment of MM and mostly with immunomodulatory drugs (IMiDs; thalidomide, lenalidomide and pomalidomide). Areas covered: Currently thromboprophylaxis is recommended for patients who receive IMiDs-based regimens and the type of thrombophrophylaxis is based on patient-, disease- and treatment-related risk factors. Making the distinction between the intrinsic risk of thrombosis in MM and the effect of therapy is crucial. The use of aspirin, low molecular weight heparins and warfarin are the recommended drugs but despite their appropriate use the rates of VTE are not completely eliminated. Expert commentary: Research into biomarkers of increased coagulability and their incorporation in risk assessment models could identify patients most likely to benefit from thromboprophylaxis but such models are not widely used in myeloma. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
Mazis I, Sotiropoulos I. The role of energy as a geopolitical factor for the consolidation of Greek-Israeli relations. Regional Science Inquiry. 2016;(Special Issue):27-44.Abstract
During the current historical coincidence, the geostrategic conjunction of Greece-Cyprus- Israel is a reality, in order for the three states to cope in the best possible manner with the contemporary and future challenges in the arena of international and regional relations. Having a common strategic perception of the geopolitical sub-system of the southeastern Mediterranean, Athens, Nicosia and Jerusalem strengthen day by day their political, diplomatic, economic and military relations, aiming at the preservation of stability in the area, against any revisionist factor. For the aforementioned strategic alliance, the discovery, extraction and exploitation of the hydrocarbon neo-reserves within the Greek, Cypriot and Israeli consecutive Exclusive Economic Zones, (EEZs), is the dynamic catalyst that reinforces even further the allied cooperation and effectiveness. Amidst the geopolitical transformation of the wider region of North Africa, Middle and Near East, the construction of the East Mediterranean Pipeline, (East-Med), is a common pursuit of the outmost significance, for the strategic alliance. Indeed, if the East-Med is realized, it will be able to transfer, in the first phase, the Israeli and Cypriot hydrocarbons from the off-shore neo-reserves via Greek sovereign territory and EEZ to Italy and central Europe, signaling EU’s gradual disengagement from the dependence on the Russian natural gas, allowing the EU to make its first steps of energy emancipation. Despite Ankara’s attempt for rapprochement with Jerusalem, the official Israeli position heavily leans towards an Israel-Greek-Cypriot strategic alignment, as Israel’s national security constitute the ultimate long-term priority for Jerusalem. Above all, such a development will upgrade the geopolitical status of all the three states of the strategic alliance in the regional geopolitical as well as the supra-geopolitical system.
Methenitis SK, Zaras ND, Spengos KM, Stasinaki A-NE, Karampatsos GP, Georgiadis GV, Terzis GD. Role of Muscle Morphology in Jumping, Sprinting, and Throwing Performance in Participants With Different Power Training Duration Experience. J Strength Cond Res. 2016;30(3):807-17.Abstract
The aim of the study was to examine the correlation between muscle morphology and jumping, sprinting, and throwing performance in participants with different power training duration experience. Thirty-six power-trained young men were assigned to 3 groups according to the length of their power training: less experienced (<1 year), moderately experienced (1-3 years), and experienced (4-7 years). All participants performed countermovement and squat jumps, 60-m sprint, and shot throws twice. Lean body mass (LBM) was evaluated with dual-energy x-ray absorptiometry and thigh muscle cross-sectional area (CSA) with anthropometry. The vastus lateralis architecture and fiber type composition were evaluated with ultrasonography and muscle biopsies, respectively. When all subjects were considered as 1 group (n = 36), jumping performance was correlated with LBM, fascicle length, and type II fiber CSA; sprinting performance was correlated with estimated thigh muscle CSA alone; and shot throwing was correlated with LBM and type I, IIA fiber CSA. In the least experienced group, the LBM of the lower extremities was the most significant contributor for power performance, whereas in the moderately experienced group, the LBM, architectural properties, and type II fiber percentage CSA were the most significant contributors. For the experienced group, fascicle length and type II fiber percentage CSA were the most significant factors for power performance. These data suggest that jumping performance is linked with muscle morphology, regardless of strength or power training. The vastus lateralis muscle morphology could only partially explain throwing performance, whereas it cannot predict sprinting performance. Power performance in experienced participants rely more on the quality of the muscle tissue rather than the quantity.
Gamaletsos PN, Godelitsas A, Kasama T, Kuzmin A, Lagos M, Mertzimekis TJ, Goettlicher J, Steininger R, Xanthos S, Pontikes Y, et al. The role of nano-perovskite in the negligible thorium release in seawater from Greek bauxite residue (red mud). Nature Sci. Rep. 2016;6:21737.
Dimopoulos MA, Palumbo A, Corradini P, Cavo M, Delforge M, Di Raimondo F, Weisel KC, Oriol A, Hansson M, Vacca A, et al. Safety and efficacy of pomalidomide plus low-dose dexamethasone in STRATUS (MM-010): A phase 3b study in refractory multiple myeloma. Blood [Internet]. 2016;128(4):497 - 503. WebsiteAbstract
Patients with relapsed and/or refractory multiple myeloma (RRMM) have poor prognosis. The STRATUS study assessed safety and efficacy of pomalidomide plus low-dose dexamethasone in the largest cohort to date of patients with RRMM. Patients who failed treatment with bortezomib and lenalidomide and had adequate prior alkylator therapy were eligible. Pomalidomide 4 mg was given on days 1-21 of 28-day cycles with low-dose dexamethasone 40 mg (20 mg for patients aged >75 years) on days 1, 8, 15, and 22 until progressive disease or unacceptable toxicity. Safety was the primary end point; secondary end points included overall response rate (ORR), duration of response (DOR), progression-free survival (PFS), and overall survival (OS). Among 682 patients enrolled, median age was 66 years, and median time since diagnosis was 5.3 years. Median number of prior regimens was 5. Most patients were refractory to both lenalidomide and bortezomib (80.2%). Median follow-up was 16.8 months; median duration of treatment was 4.9 months. Most frequent grade 3/4 treatment-emergent adverse events were hematologic (neutropenia [49.7%], anemia [33.0%], and thrombocytopenia [24.1%]). Most common grade 3/4 nonhematologic toxicities were pneumonia (10.9%) and fatigue (5.9%). Grade 3/4 venous thromboembolism and peripheral neuropathy were rare (1.6% each). The ORR was 32.6%, and the median DOR was 7.4 months. Median PFS and OS were 4.6 months and 11.9 months, respectively. We present the largest trial to date evaluating pomalidomide plus low-dose dexamethasone in patients with RRMM, further confirming that this regimen offers clinically meaningful benefit and is generally well tolerated. www.Clinicaltrials.gov identifier NCT01712789. © 2016 by The American Society of Hematology.
Dimopoulos MA, Palumbo A, Corradini P, Cavo M, Delforge M, Di Raimondo F, Weisel KC, Oriol A, Hansson M, Vacca A, et al. Safety and efficacy of pomalidomide plus low-dose dexamethasone in STRATUS (MM-010): A phase 3b study in refractory multiple myeloma. Blood [Internet]. 2016;128(4):497 - 503. WebsiteAbstract
Patients with relapsed and/or refractory multiple myeloma (RRMM) have poor prognosis. The STRATUS study assessed safety and efficacy of pomalidomide plus low-dose dexamethasone in the largest cohort to date of patients with RRMM. Patients who failed treatment with bortezomib and lenalidomide and had adequate prior alkylator therapy were eligible. Pomalidomide 4 mg was given on days 1-21 of 28-day cycles with low-dose dexamethasone 40 mg (20 mg for patients aged >75 years) on days 1, 8, 15, and 22 until progressive disease or unacceptable toxicity. Safety was the primary end point; secondary end points included overall response rate (ORR), duration of response (DOR), progression-free survival (PFS), and overall survival (OS). Among 682 patients enrolled, median age was 66 years, and median time since diagnosis was 5.3 years. Median number of prior regimens was 5. Most patients were refractory to both lenalidomide and bortezomib (80.2%). Median follow-up was 16.8 months; median duration of treatment was 4.9 months. Most frequent grade 3/4 treatment-emergent adverse events were hematologic (neutropenia [49.7%], anemia [33.0%], and thrombocytopenia [24.1%]). Most common grade 3/4 nonhematologic toxicities were pneumonia (10.9%) and fatigue (5.9%). Grade 3/4 venous thromboembolism and peripheral neuropathy were rare (1.6% each). The ORR was 32.6%, and the median DOR was 7.4 months. Median PFS and OS were 4.6 months and 11.9 months, respectively. We present the largest trial to date evaluating pomalidomide plus low-dose dexamethasone in patients with RRMM, further confirming that this regimen offers clinically meaningful benefit and is generally well tolerated. www.Clinicaltrials.gov identifier NCT01712789. © 2016 by The American Society of Hematology.
Karavasilis V, Papadimitriou C, Gogas H, Kouvatseas G, Pentheroudakis G, Koutras A, Christodoulou C, Bafaloukos D, Samantas E, Pisanidis N, et al. Safety and Tolerability of Anthracycline-Containing Adjuvant Chemotherapy in Elderly High-Risk Breast Cancer Patients. Clinical Breast Cancer [Internet]. 2016;16(4):291 - 298.e3. WebsiteAbstract
Micro-Abstract We characterized the feasibility and toxicity profile of anthracycline-containing adjuvant chemotherapy in women >65 years of age with early breast cancer. Elderly breast cancer patients derive clinical benefit comparable with that of younger patients, mainly at the cost of increased risk of hematological toxicity. © 2015 Elsevier Inc.
Karavasilis V, Papadimitriou C, Gogas H, Kouvatseas G, Pentheroudakis G, Koutras A, Christodoulou C, Bafaloukos D, Samantas E, Pisanidis N, et al. Safety and Tolerability of Anthracycline-Containing Adjuvant Chemotherapy in Elderly High-Risk Breast Cancer Patients. Clinical Breast Cancer [Internet]. 2016;16(4):291 - 298.e3. WebsiteAbstract
Micro-Abstract We characterized the feasibility and toxicity profile of anthracycline-containing adjuvant chemotherapy in women >65 years of age with early breast cancer. Elderly breast cancer patients derive clinical benefit comparable with that of younger patients, mainly at the cost of increased risk of hematological toxicity. © 2015 Elsevier Inc.
Duvic M, Dimopoulos M. The safety profile of vorinostat (suberoylanilide hydroxamic acid) in hematologic malignancies: A review of clinical studies. Cancer Treatment Reviews [Internet]. 2016;43:58 - 66. WebsiteAbstract
Histone acetyltransferases and histone deacetylases (HDACs) are multifunctional enzymes that posttranslationally modify both histone and nonhistone acetylation sites, affecting a broad range of cellular processes (e.g., cell cycle, apoptosis, and protein folding) often dysregulated in cancer. HDAC inhibitors are small molecules that directly interact with HDAC catalytic sites preventing the removal of acetyl groups, thereby counteracting the effects of HDACs. Since the first HDAC inhibitor, valproic acid, was investigated as a potential antitumor agent, there have been a number of other HDAC inhibitors developed to improve efficacy and safety. Despite significant progress in the management of patients with hematologic malignancies, overall survival is still poor. The discovery that HDACs may play a role in hematologic malignancies and preclinical studies showing promising activity with HDAC inhibitors in various tumor types, led to clinical evaluation of HDAC inhibitors as potential treatment options for patients with advanced hematologic malignancies. The Food and Drug Administration has approved two HDAC inhibitors, vorinostat (2006) and romidepsin (2009), for the treatment of cutaneous T-cell lymphoma. This review highlights the safety of HDAC inhibitors currently approved or being investigated for the treatment of hematologic malignancies, with a specific focus on the safety experience with vorinostat in cutaneous T-cell lymphoma. © 2016.
Vrontaki E, Melagraki G, Mavromoustakos T, Afantitis A. Searching for anthranilic acid-based thumb pocket 2 HCV NS5B polymerase inhibitors through a combination of molecular docking, 3D-QSAR and virtual screening. Journal of Enzyme Inhibition and Medicinal Chemistry [Internet]. 2016;31(1):38 - 52. Website
Feloni E, Nastos PT, Matsangouras IT. Seasonal Synoptic Characteristics of Heavy Rain Events in the Attica Region. In: {Karacostas TS, Bais AF, Nastos PT} PERSPECTIVES ON ATMOSPHERIC SCIENCES. {PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS}: {Aristotle Univ Thessaloniki, Sch Phys, Lab Atmospher Phys; Aristotle Univ Thessaloniki, Sch Geol, Dept Meteorol & Climatol; Hellen Meteorol Soc; Mariolopoulos Kanaginis Fdn Environm Sci}; 2016. pp. 391-396.Abstract
{The objective of this study is the analysis of heavy precipitation events occurred in Attica region during the period 2007-2013, along with the determination of their characteristics depending on the season and their corresponding impact. These events were selected according to two criteria; the lightning occurrence-information that was acquired from the Hellenic National Meteorological Service Precision Lightning Sensors Network (HNMS-PLN)-and the high rainfall intensity, provided by the Hydrological Observatory of Athens (HOA) rainfall network. On the one hand, the composite means and anomalies of the respective synoptic conditions, which were based on the reanalysis data sets acquired from the National Centers for Environmental Prediction-National Center for Atmospheric Research (NCEP-NCAR), along with the frontal activity over Greece, have been analyzed. On the other hand, special attention has been given to the configuration of specific instability indices, during the examined rainfall events. The aforementioned study is an effort to shed light to the rainfall events' features, with respect to their seasonal incidence and their relation to phenomena such as floods and hail.}
Avivi I, Cohen YC, Joffe E, Benyamini N, Held-Kuznetsov V, Trestman S, Terpos E, Dimopoulos MA, Kastritis E. Serum free immunoglobulin light chain fingerprint identifies a subset of newly diagnosed multiple myeloma patients with worse outcome. Hematological Oncology [Internet]. 2016. WebsiteAbstract
Multiple myeloma (MM) is a multi-subclonal malignancy with relatively high heterogeneity. Patients who initially presented with both monoclonal-protein (MP) and free light chain (FLC) secretion but then relapsed with a light chain escape pattern have been shown to reflect disease clonal evolution and to bare a worse prognosis. We hypothesized that a discordant MP/FLC pattern at diagnosis may reflect a similar clonal evolution that had occurred prior to diagnosis of active myeloma, conferring a worse outcome. We analyzed 255 consecutive newly diagnosed MM patients who received first line bortezomib-based therapy between 2007 and 2014, hypothesizing that their MP/FLC fingerprint at diagnosis reflects clonal heterogeneity and, therefore, affects outcome. An involved FLC level ≥ 700 mg/L and MP ≥ 2.5 g/L were used as cutoffs for low vs high FLC and MP levels, respectively. Patients were divided into 4 subgroups according to their involved FLC and MP blood levels at diagnosis: HiLC and HiMP for patients with either a predominant FLC or a predominant MP, respectively, and HiLC-MP and LoLC-MP when both FLC and MP were increased or decreased, respectively. There were 68 (27%) patients with HiLC, which presented more often with International Staging System-3 stage (P < .0001). Multivariate analysis showed that HiLC was associated with a 5.1-fold risk for mortality in a multivariate model (95% confidence interval [CI], 1.34-19.68). Both HiLC and HiLC-MP phenotypes were associated with shorter progression-free survival (hazard ratio of 2.66 [95% CI, 1.33-5.32] and 2.82 [95% CI, 1.37-5.83], respectively), independently of other prognostic factors, including the use of autograft. Thus, we identified an LC predominant secretory fingerprint (HiLC phenotype) at diagnosis as a potential independent risk factor that may affect disease control and survival in newly diagnosed MM patients treated with bortezomib-based induction therapy; this may represent increased subclonal heterogeneity. © 2016 John Wiley & Sons, Ltd.
Chrelias G, Makris G-M, Papanota A-M, Spathis A, Salamalekis G, Sergentanis TN, Rizos D, Karakitsos P, Chrelias C. Serum inhibin and leptin: Risk factors for pre-eclampsia?. Clinica Chimica Acta [Internet]. 2016;463:84-87. Website
Chovalopoulou M-E, Valakos ED, Manolis SK. Sex determination by three-dimensional geometric morphometrics of craniofacial form. Anthropol Anz. 2016;73(3):195-206.Abstract
SUMMARY: The purpose of the present study is to define which regions of the cranium, the upper-face, the orbits and the nasal are the most sexually dimorphic, by using three-dimensional geometric morphometric methods, and investigate the effectiveness of this method in determining sex from the shape of these regions. The study sample consisted of 176 crania of known sex (94 males, 82 females) belonging to individuals who lived in Greece during the 20(th) century. The three-dimensional co-ordinates of 31 ecto-cranial landmarks were digitized using a MicroScribe 3DX contact digitizer. Goodall's F-test was performed in order to compare statistical differences in shape between males and females. Generalized Procrustes Analysis (GPA) was used to obtain size and shape variables for statistical analysis. Shape, Size and Form analyses were carried out by logistic regression and discriminant function analysis. The results indicate that there are shape differences between the sexes in the upper-face and the orbits. The highest shape classification rate was obtained from the upper-face region. The centroid size of the caraniofacial and the orbital regions was smaller in females than males. Moreover, it was found that size is significant for sexual dimorphism in the upper-face region. As anticipated, the classification accuracy improves when both size and shape are combined. The findings presented here constitute a firm basis upon which further research can be conducted.
Chovalopoulou M-E, Valakos ED, Manolis SK. Sex determination by three-dimensional geometric morphometrics of the vault and midsagittal curve of the neurocranium in a modern Greek population sample. Homo. 2016;67(3):173-87.Abstract
The aim of this study is to assess sexual dimorphism of adult crania in the vault and midsagittal curve of the vault using three-dimensional geometric morphometric methods. The study sample consisted of 176 crania of known sex (94 males, 82 females) belonging to individuals who lived during the 20th century in Greece. The three-dimensional co-ordinates of 31 ecto-cranial landmarks and 30 semi-landmarks were digitized using a MicroScribe 3DX contact digitizer. Generalized Procrustes analysis (GPA) was used to obtain size and shape variables for statistical analysis. Shape, size and form analyses were carried out by logistic regression and three discriminant function analyses. Results indicate that there are shape differences between sexes. Females in the region of the parietal bones are narrower and the axis forming the frontal and occipital bones is more elongated; the frontal bone is more vertical. Sex-specific shape differences give better classification results in the vault (79%) compared with the midsagittal curve of the neurocranium (68.8%). Size alone yielded better results for cranial vault (82%), while for the midsagittal curve of the vault the result is poorer (68.1%). As anticipated, the classification accuracy improves when both size and shape are combined (89.2% for vault, and 79.4% for midsagittal curve of the vault). These latter findings imply that, in contrast to the midsagittal curve of the neurocranium, the shape of the cranial vault can be used as an indicator of sex in the modern Greek population.
Damilou A, Apostolakis S, Thrapsanioti E, Theleritis C, Smyrnis N. Shared and distinct oculomotor function deficits in schizophrenia and obsessive compulsive disorder. Psychophysiology. 2016;53:796–805.
Vassilakis E, Tsokos Α, Kotsi Ε. Shoreline change detection and coastal erosion monitoring using digital processing of a time series of high spatial resolution remote sensing data. 14th Intern. Conf. of the Geological Society of Greece [Internet]. 2016. pdfAbstract
The long term change of the shoreline is a phenomenon, which is factored in the design of construction projects along the coastal zone. This study presents a meth-odology that aims to quantify the shoreline displacement rate. The described meth-odology involves the interpretation of different remote sensing data types, which make up a quite dense time series of representations for the coastline spanning from 1987 to 2012. The representation of the shoreline is based on geometrically corrected (ortho-rectified), historical, analogue, panchromatic, high resolution aerial photos of the area (1987, 1996) and latest generation, digital, multispectral, high resolution satellite images (2000, 2008, 2012). In all cases the images were digitally processed and optically optimized in order to produce a highly accurate representation of the shoreline in each time period. All the data were imported in a Geographic Information System platform, where they were subjected to comparison and geo-statistical analysis. A large number of sections perpendicular to the coast (every 100 meters) was drawn and the relative motion of the coastline was calcu-lated for each of them. The average rate of the calculated erosion is in the order of 24mm/year whilst extreme rates of 1m/year were also observed in specific posi-tions.
Varytis P, Stefanou N. Silver-coated metallic and dielectric magnetic nanospheres: Localized surface plasmons and circular dichroism. Optics Communications. 2016;360:40-45.Abstract
A thorough study of localized surface plasmons and associated strong circular dichroism, which can occur in silver-coated metallic and dielectric magnetic nanospheres, is reported by means of both quasistatic and full electrodynamic calculations taking into account the actual (magneto) optical response of the constituent materials, including dispersion and losses. It is shown that such composite magnetoplasmonic nanoparticles offer a versatile platform for engineering hybrid plasmon modes that give rise to sharp absorption resonances and subject to large magneto-optic splitting, leading to giant magnetic circular dichroism signals, by properly choosing the different materials and tuning the geometrical parameters involved.
Weiberg E, Unkel I, Kouli K, Holmgren K, Avramidis P, Bonnier A, Dibble F, Finné M, Izdebski A, Katrantsiotis C, et al. The socio-environmental history of the Peloponnese during the Holocene: Towards an integrated understanding of the past. Quaternary Science Reviews [Internet]. 2016;136:40-65. Publisher's VersionAbstract
Published archaeological, palaeoenvironmental, and palaeoclimatic data from the Peloponnese in Greece are compiled, discussed and evaluated in order to analyse the interactions between humans and the environment over the last 9000 years. Our study indicates that the number of human settlements found scattered over the peninsula have quadrupled from the prehistoric to historical periods and that this evolution occurred over periods of climate change and seismo–tectonic activity. We show that societal development occurs both during periods of harsh as well as favourable climatic conditions. At some times, some settlements develop while others decline. Well-known climate events such as the 4.2 ka and 3.2 ka events are recognizable in some of the palaeoclimatic records and a regional decline in the number and sizes of settlements occurs roughly at the same time, but their precise chronological fit with the archaeological record remains uncertain. Local socio-political processes were probably always the key drivers behind the diverse strategies that human societies took in times of changing climate. The study thus reveals considerable chronological parallels between societal development and palaeoenvironmental records, but also demonstrates the ambiguities in these correspondences and, in doing so, highlights some of the challenges that will face future interdisciplinary projects. We suggest that there can be no general association made between societal expansion phases and periods of advantageous climate. We also propose that the relevance of climatic and environmental regionality, as well as any potential impacts of seismo-tectonics on societal development, need to be part of the interpretative frameworks.
Mazis I. Причины создания НАТО. In: Доклад на Конференции, посвященной 71-й годовщине Великой Победы . Athens, Greece: Greek-Russian Friendship Club "Dialogos"; 2016.Abstract
Основание НАТО 4 апреля 1949 года драматическим образом ознаменовало окончательный распад альянса трех великих держав - США, Великобритании и СССР, созданного во время Второй мировой войны. Вместе с тем, это стало началом новой, послевоенной биполярной системе баланса сил, главным проявлением которой стала Холодная война. Это тотальное политическое противостояние между двумя сверхдержавами и их сателлитами, распространившееся на большую часть нашей планеты, началось на послевоенных руинах Старого Света, где столкнулись исторически противоположные геополитические устремления обеих сторон - противостояние, усиленное ростом числа откровенных мистификаций, скрытые мотивов и стереотипов, а также конфликтом национальных интересов. В фундаменте этого противостояния лежат принципы и ценности, с 1945 года взятые Уставом ООН в качестве основы для создания послевоенной международной системы. Главные пункты этого Устава объявляют применение насилия в международных отношениях как способ разрешения международных споров нелегитимным (статьи 2.3 и 2.4), обязывают уважать внутренние дела государства (статья 2.7), а также определяют право государств на индивидуальную или коллективную самооборону (как «соПейме зе!^-сЫепсе») - это определяется в статье 21 Устава ООН (а также, позже, в статье 5 Устава НАТО, и в соответствующих статьях Варшавского договора). Задуманное, как это часто бывает, с благими намерениями, в конце концов все это превратилось в гигантский ком неуверенности, страха и взаимного недоверия, а порой и открытой ненависти с обеих сторон. Первым последствием стало разделение Германии, что придало последующему разделению Европы «официальный». Это стало знаковым событием, обнажившим конфликт интересов между Западом и СССР - блокада Берлина советскими войсками (19481949), после чего было создано НАТО.
lxvii._prichiny_sozdaniya_doklad_na_konferencii_posvyashchennoy_71-y_godovshchine_velikoy_pobedy_19_maya_2016g.pdf
Καμπερίδου Ειρήνη. Προσκεκλημένη-συμμετοχή στην Ημερίδα Meet up – Κοινωνική Επιχειρηματικότητα Συμβουλές & Σύμβουλοι. «Διαδραστική Συνάντηση Ενδυνάμωσης Δεξιοτήτων». Europe Direct City of Athens. 2016.Abstract
Προσκεκλημένη-συμμετοχή στην Ημερίδα Meet up – Κοινωνική Επιχειρηματικότητα Συμβουλές & Σύμβουλοι. «Διαδραστική Συνάντηση Ενδυνάμωσης Δεξιοτήτων». Europe Direct City of Athens, Sesbo-social enterprise skills, IKY,  Funded by Erasmus+ Programme of the European Union, Αθήνα, 25 Οκτωβρίου 2016.
Lovejoy S, Varotsos C. Scaling regimes and linear/nonlinear responses of last millennium climate to volcanic and solar forcings. Earth System Dynamics [Internet]. 2016;7(1):133-150. Publisher's VersionAbstract
At scales much longer than the deterministic predictability limits (about 10 days), the statistics of the atmosphere undergoes a drastic transition, the high-frequency weather acts as a random forcing on the lower-frequency macroweather. In addition, up to decadal and centennial scales the equivalent radiative forcings of solar, volcanic and anthropogenic perturbations are small compared to the mean incoming solar flux. This justifies the common practice of reducing forcings to radiative equivalents (which are assumed to combine linearly), as well as the development of linear stochastic models, including for forecasting at monthly to decadal scales. In order to clarify the validity of the linearity assumption and determine its scale range, we use last millennium simulations, with both the simplified Zebiak–Cane (ZC) model and the NASA GISS E2-R fully coupled GCM. We systematically compare the statistical properties of solar-only, volcanic-only and combined solar and volcanic forcings over the range of timescales from 1 to 1000 years. We also compare the statistics to multiproxy temperature reconstructions. The main findings are (a) that the variability in the ZC and GCM models is too weak at centennial and longer scales; (b) for longer than  ≈  50 years, the solar and volcanic forcings combine subadditively (nonlinearly) compounding the weakness of the response; and (c) the models display another nonlinear effect at shorter timescales: their sensitivities are much higher for weak forcing than for strong forcing (their intermittencies are different) and we quantify this with statistical scaling exponents.
Androulidakis I, Zambon M. Stefan-Sussmann singular foliations, singular subalgebroids and their associated sheaves. Int. J. Geom. Methods Phys. [Internet]. 2016;13:17 pp. Publisher's VersionAbstract
We explain and motivate Stefan–Sussmann singular foliations, and by replacing the tangent bundle of a manifold with an arbitrary Lie algebroid, we introduce singular subalgebroids. Both notions are defined using compactly supported sections. The main results of this note are an equivalent characterization, in which the compact support condition is removed, and an explicit description of the sheaf associated to any Stefan–Sussmann singular foliation or singular subalgebroid.
az_sheaves_28mar2016.pdf
Revithiadou A, Spyropoulos V. Stress at the interface: Phases, accents and dominance. Linguistic Analysis. 2016;41(1-2):1-71.Abstract
This article explores patterns of accentuation that are profoundly af- fected by the morphosyntactic structure and, especially, by the way the constituents of a word are assembled and concomitantly processed by the PF component. We first review well-known cases of stress-affecting affixation in English from various theoretical perspectives in order to discover key aspects of the architectural and/or lexical item-specific conditions that instigate accentual dominance, that is, the attraction of stress by certain morphological constituents. We propose a path of analysis along the lines of Embick’s (2014) phase-based approach to the morphosyntax/phonology interface, according to which the ability of the exponent of a morpheme to trigger a cyclic phonological rule (phonological cyclicity) is dissociated from the phase status of the morpheme (phase cyclicity) and becomes an unpredictable property of its exponent. Based on an examination of the more intricate pat- terns of accentual dominance exhibited by a group of lexical stress systems—namely Greek, Vedic Sanskrit and Yakima Sahaptin—we propose that dominance emanates from both the architectural properties of the Grammar and the idiosyncratic lexical properties of the exponents of the morphosyntactic constituents, but not in a totally arbitrary way as predicted by Embick’s approach. Notably, our study reveals that a set of significant, so far unnoticed, implicational relations between phasehood and phonological cyclicity apply: No system has dominant exponents of non-phase heads without having dominant exponents of phase heads; and, moreover, no system has dominant accentless exponents without having dominant accented ones.
Bertini A, Sadori L, Combourieu-Nebout N, Donders TH, Kouli K, Koutsodendris A, Joannin S, Masi A, Mercuri AM, Panagiotopoulos K, et al. All together now: an international palynological team documents vegetation and climate changes during the last 500 kyr at lake Ohrid (SE Europe). Alpine and Mediterranean Quaternary [Internet]. 2016;29(2):201-210. Publisher's VersionAbstract
Lake Ohrid (Balkan peninsula) is the oldest European extant lake and one of the deepest and largest. Such a unique, terrestrial natural archive is especially relevant for both paleoenvironmental and paleoclimatic reconstructions but also for genetic studies. In the frame of the International Continental Scientific Drilling Program (ICDP), a deep drilling campaign was carried out within the scope of the Scientific Collaboration on Past Speciation Conditions in Lake Ohrid (SCOPSCO) project in 2013. Here, we present the summary of palynological analyses carried out in the upper 200 m of the overall 569 m long DEEP site sediment succession from the central part of the lake. These studies, performed by an international palynological team, document the main floristic, vegetation and climate changes during the last ca 500 kyr, at a millennial-scale resolution (~1.6 kyr). The continuous sediment infill permitted to trace multiple non-forested/ forested phases as a response to Glacial/Interglacial cycles as well as to sub-Milankovitch climate changes. The pollen record, corresponding with marine isotope stages MIS 13 to MIS 1, points to a progressive change from cooler and wetter to warmer and drier interglacials. New palynological studies are underway to reconstruct vegetational and climatic conditions over older intervals as well as to obtain high resolution data for some key intervals such as MIS 5-6, MIS 11-12, MIS 35-42. The complete record of changes in flora composition and vegetation during both glacials and interglacials will furnish indispensable insights for understanding the role of refugia, ecosystem resilience and maintenance of terrestrial biodiversity in the Mediterranean area.
Alguel Y, Amillis S, Leung J, Lambrinidis G, Capaldi S, Scull NJ, Craven G, Iwata S, Armstrong A, Mikros E, et al. Structure of eukaryotic purine/H(+) symporter UapA suggests a role for homodimerization in transport activity. Nat Commun. 2016;7:11336.Abstract
The uric acid/xanthine H(+) symporter, UapA, is a high-affinity purine transporter from the filamentous fungus Aspergillus nidulans. Here we present the crystal structure of a genetically stabilized version of UapA (UapA-G411VΔ1-11) in complex with xanthine. UapA is formed from two domains, a core domain and a gate domain, similar to the previously solved uracil transporter UraA, which belongs to the same family. The structure shows UapA in an inward-facing conformation with xanthine bound to residues in the core domain. Unlike UraA, which was observed to be a monomer, UapA forms a dimer in the crystals with dimer interactions formed exclusively through the gate domain. Analysis of dominant negative mutants is consistent with dimerization playing a key role in transport. We postulate that UapA uses an elevator transport mechanism likely to be shared with other structurally homologous transporters including anion exchangers and prestin.
Preketes-Sigalas K, Lagoyannis A, Axiotis M, Harissopulos S, Kokkoris M, Mertzimekis TJ, Paneta V, Provatas G. Study of the reaction for {PIGE} applications. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms. 2016;368:71–74.Abstract
Abstract The differential cross sections of the 2125 keV $\gamma$–ray, emitted by the $^{11}$B(p, p'$\gamma$)$^{11}$B reaction were measured at six (6) angles and at proton energies from 2.5 to 5.0 MeV. The experimental setup consisted of three (3) 100% relative efficiency \{HPGe\} detectors placed on a motorized turntable. The comparison between the present measurements, which have an overall uncertainty of $\sim$8%, and previous ones from literature gives contradictory results. While there are large differences with previous differential cross-section measurements from literature, there is good agreement with previous thick-target yield ones. Additional thick-target measurements were performed in an effort to explain the observed discrepancies.
Matsangouras IT, Nastos PT, Pytharoulis I. Study of the tornado event in Greece on March 25, 2009: Synoptic analysis and numerical modeling using modified topography. Atmospheric Research [Internet]. 2016;169:566-583. Website
Chrysostomou S. Technology in the music classroom in Greece: Navigating through the forest by focusing on the tree. In: Ruthmann, A. & Mantie, R. (eds). Oxford Handbook of Technology & Music Education. Oxford: Oxford University Press; 2016.
Tense and aspect after the New Testament
Moser A. Tense and aspect after the New Testament. In: Runge, Steven E. & Christopher J. Fresh (eds.) The Greek Verb Revisited: A Fresh Approach for Biblical Exegesis. Bellingham: Lexham Press; 2016. pp. 539-562. Publisher's VersionAbstract
The aim of this paper is to show that the knowledge of the history of Greek after the New Testament and the knowledge of its outcome, i.e. Modern Greek, can provide the tools for a better understanding of some of the linguistic problems presented by New Testament Greek. The testing ground for this claim will be aspect and its relationship to Aktionsart and tense. The paper starts with a brief overview of the Modern Greek verbal system in comparison to the Classical Greek verb, continues with a brief discussion of a theoretical approach to tense and aspect and its application to Modern Greek, and proceeds retrospectively, examining the situation in Early, Classical and New Testament Greek in the light of the Modern Greek data .
The "text of life" in Vito Acconci'sDiary of a Body. Sillages Critiques [Internet]. 2016;21. Publisher's VersionAbstract
Vito Acconci’s early artistic practice combines textuality, visuality, and the involvement with the physical body. It also revolves around the tension between the transience of the performance and the various forms with which the artist’s activities have been devised, recorded, and documented. The voluminous archive that was assembled by Gregory Volk in the Diary of a Body 1969-1973 is worth examining in that respect, since these visual and verbal documents are not only secondary to the event, but make up an integral part of the artist’s early work. Therefore this essay revisits Vito Acconci’s notes and photographs as an assemblage that preserves the experiential substance of the artist’s practice, and also speaks of its in/transitive character, inviting reflection on the connections between writing, performance, and the ground of experience. A paratext to the performances and a continuation of his early writings, the diary is a storehouse that has a documentary value against the grain, which the essay dwells on.
Bagratuni T, Terpos E, Eleutherakis-Papaiakovou E, Kalapanida D, Gavriatopoulou M, Migkou M, Liacos C-I, Tasidou A, Matsouka C, Mparmparousi D, et al. TLR4/TIRAP polymorphisms are associated with progression and survival of patients with symptomatic myeloma. British Journal of Haematology [Internet]. 2016;172(1):44 - 47. WebsiteAbstract
Myeloma cells thrive in an environment of sustained inflammation, which impacts the development and evolution of the disease, as well as drug resistance. We evaluated the impact of genetic polymorphisms in the Toll-like receptor 4 (TLR4) pathway, which have been implicated in different inflammatory responses in the outcomes of patients with symptomatic multiple myeloma (MM) who have received contemporary therapies. We found that the presence of single nucleotide polymorphisms (SNPs) in both the TLR4 and toll/interleukin-1 receptor (TIR)-associated protein (TIRAP) genes was associated with lower response to primary therapy mainly for patients who received immunomodulatory drugs but not in patients treated with bortezomib-based therapies. Furthermore, TIRAP SNP was associated with a significantly shorter progression-free survival and overall survival, independently of other prognostic factors, such as age, transplant, International Staging System stage, lactate dehydrogenase and cytogenetics. This is the first study to demonstrate the effect of SNPs in TLR4/TIRAP in MM. Our data indicate that genetic variability in the immune system may be associated with different responses to antimyeloma therapies and may be a critical component affecting the natural history of the disease, providing the basis for further investigation of the role of these pathways in myeloma. © 2016 John Wiley & Sons Ltd.
Antoniou E, Margonis GA, Angelou A, Pikouli A, Argiri P, Karavokyros I, Papalois A, Pikoulis E. The TNBS-induced colitis animal model: An overview. Ann Med Surg (Lond). 2016;11:9-15.Abstract
BACKGROUND: Despite recent advances the pathogenesis of Crohn's disease remains incompletely understood. A variety of animal models have been utilized in an effort to provide further insights and develop more therapeutic options. In order to simulate, to an extent, the pathogenesis and the clinical course of the disease, TNBS induced colitis is often used. Various approaches for inducing TNBS -colitis have been described in the literature. METHODS/RESULTS: In this review, we sought to present the animal model of TNBS induced colitis and outline the pathogenesis, pathophysiology, clinical course and pathological characteristics of the model. Furthermore, we describe the differences among those protocols regarding types of animals and colitis induction. DATA SOURCES: The MEDLINE database was thoroughly searched using the keywords: TNBS, colitis, Crohn's disease, animal model. Two investigators independently reviewed the abstracts and appropriate articles were included in this review. Additional articles were gathered and evaluated. CONCLUSION: The aim of this study was to thoroughly present an updated review of the TNBS-induced colitis protocols that are implemented by researchers.
Tchoumtchoua J, Theocharis S, Halabalaki M, Efstathiou A, Gaboriaud-Kolar N, Smirlis D, Konstantinidou AE, Patsouris ES, Skaltsounis AL. Toxicological study of the indirubin derivative 7BIO. Planta Medica. 2016;81(S 01):P952.
Fountzilas G, Giannoulatou E, Alexopoulou Z, Zagouri F, Timotheadou E, Papadopoulou K, Lakis S, Bobos M, Poulios C, Sotiropoulou M, et al. TP53 mutations and protein immunopositivity may predict for poor outcome but also for trastuzumab benefit in patients with early breast cancer treated in the adjuvant setting. Oncotarget [Internet]. 2016;7(22):32731 - 32753. WebsiteAbstract
Background: We investigated the impact of PIK3CA and TP53 mutations and p53 protein status on the outcome of patients who had been treated with adjuvant anthracycline-taxane chemotherapy within clinical trials in the pre- and post-trastuzumab era. Results: TP53 and PIK3CA mutations were found in 380 (21.5%) and 458 (25.9%) cases, respectively, including 104 (5.9%) co-mutated tumors; p53 immunopositivity was observed in 848 tumors (53.5%). TP53 mutations (p < 0.001) and p53 protein positivity (p = 0.001) were more frequent in HER2-positive and triple negative (TNBC) tumors, while PIK3CA mutations were more frequent in Luminal A/B tumors (p < 0.001). TP53 mutation status and p53 protein expression but not PIK3CA mutation status interacted with trastuzumab treatment for disease-free survival; patients with tumors bearing TP53 mutations or immunopositive for p53 protein fared better when treated with trastuzumab, while among patients treated with trastuzumab those with the above characteristics fared best (interaction p = 0.017 for mutations; p = 0.015 for IHC). Upon multivariate analysis the above interactions remained significant in HER2-positive patients; in the entire cohort, TP53 mutations were unfavorable in patients with Luminal A/B (p = 0.003) and TNBC (p = 0.025); p53 immunopositivity was strongly favorable in patients treated with trastuzumab (p = 0.009). Materials and Methods: TP53 and PIK3CA mutation status was examined in 1766 paraffin tumor DNA samples with informative semiconductor sequencing results. Among these, 1585 cases were also informative for p53 protein status assessed by immunohistochemistry (IHC; 10% positivity cut-off). Conclusions: TP53 mutations confer unfavorable prognosis in patients with Luminal A/B and TNBC tumors, while p53 immunopositivity may predict for trastuzumab benefit in the adjuvant setting.
Fountzilas G, Giannoulatou E, Alexopoulou Z, Zagouri F, Timotheadou E, Papadopoulou K, Lakis S, Bobos M, Poulios C, Sotiropoulou M, et al. TP53 mutations and protein immunopositivity may predict for poor outcome but also for trastuzumab benefit in patients with early breast cancer treated in the adjuvant setting. Oncotarget [Internet]. 2016;7(22):32731 - 32753. WebsiteAbstract
Background: We investigated the impact of PIK3CA and TP53 mutations and p53 protein status on the outcome of patients who had been treated with adjuvant anthracycline-taxane chemotherapy within clinical trials in the pre- and post-trastuzumab era. Results: TP53 and PIK3CA mutations were found in 380 (21.5%) and 458 (25.9%) cases, respectively, including 104 (5.9%) co-mutated tumors; p53 immunopositivity was observed in 848 tumors (53.5%). TP53 mutations (p < 0.001) and p53 protein positivity (p = 0.001) were more frequent in HER2-positive and triple negative (TNBC) tumors, while PIK3CA mutations were more frequent in Luminal A/B tumors (p < 0.001). TP53 mutation status and p53 protein expression but not PIK3CA mutation status interacted with trastuzumab treatment for disease-free survival; patients with tumors bearing TP53 mutations or immunopositive for p53 protein fared better when treated with trastuzumab, while among patients treated with trastuzumab those with the above characteristics fared best (interaction p = 0.017 for mutations; p = 0.015 for IHC). Upon multivariate analysis the above interactions remained significant in HER2-positive patients; in the entire cohort, TP53 mutations were unfavorable in patients with Luminal A/B (p = 0.003) and TNBC (p = 0.025); p53 immunopositivity was strongly favorable in patients treated with trastuzumab (p = 0.009). Materials and Methods: TP53 and PIK3CA mutation status was examined in 1766 paraffin tumor DNA samples with informative semiconductor sequencing results. Among these, 1585 cases were also informative for p53 protein status assessed by immunohistochemistry (IHC; 10% positivity cut-off). Conclusions: TP53 mutations confer unfavorable prognosis in patients with Luminal A/B and TNBC tumors, while p53 immunopositivity may predict for trastuzumab benefit in the adjuvant setting.
Hofstra ML, Sauvageot N, Albert J, Alexiev I, Garcia F, Struck D, Van de Vijver DAMC, Åsjö B, Beshkov D, Coughlan S, et al. Transmission of HIV Drug Resistance and the Predicted Effect on Current First-line Regimens in Europe. Clin Infect Dis. 2016;62(5):655-663.Abstract
BACKGROUND: Numerous studies have shown that baseline drug resistance patterns may influence the outcome of antiretroviral therapy. Therefore, guidelines recommend drug resistance testing to guide the choice of initial regimen. In addition to optimizing individual patient management, these baseline resistance data enable transmitted drug resistance (TDR) to be surveyed for public health purposes. The SPREAD program systematically collects data to gain insight into TDR occurring in Europe since 2001. METHODS: Demographic, clinical, and virological data from 4140 antiretroviral-naive human immunodeficiency virus (HIV)-infected individuals from 26 countries who were newly diagnosed between 2008 and 2010 were analyzed. Evidence of TDR was defined using the WHO list for surveillance of drug resistance mutations. Prevalence of TDR was assessed over time by comparing the results to SPREAD data from 2002 to 2007. Baseline susceptibility to antiretroviral drugs was predicted using the Stanford HIVdb program version 7.0. RESULTS: The overall prevalence of TDR did not change significantly over time and was 8.3% (95% confidence interval, 7.2%-9.5%) in 2008-2010. The most frequent indicators of TDR were nucleoside reverse transcriptase inhibitor (NRTI) mutations (4.5%), followed by nonnucleoside reverse transcriptase inhibitor (NNRTI) mutations (2.9%) and protease inhibitor mutations (2.0%). Baseline mutations were most predictive of reduced susceptibility to initial NNRTI-based regimens: 4.5% and 6.5% of patient isolates were predicted to have resistance to regimens containing efavirenz or rilpivirine, respectively, independent of current NRTI backbones. CONCLUSIONS: Although TDR was highest for NRTIs, the impact of baseline drug resistance patterns on susceptibility was largest for NNRTIs. The prevalence of TDR assessed by epidemiological surveys does not clearly indicate to what degree susceptibility to different drug classes is affected.
Leblond V, Kastritis E, Advani R, Ansell SM, Buske C, Castillo JJ, García-Sanz R, Gertz M, Kimby E, Kyriakou C, et al. Treatment recommendations from the Eighth International Workshop on Waldenström's Macroglobulinemia. Blood [Internet]. 2016;128(10):1321 - 1328. WebsiteAbstract
Waldenström macroglobulinemia (WM) is a distinct B-cell lymphoproliferative disorder for which clearly defined criteria for the diagnosis, initiation of therapy, and treatment strategy have been proposed as part of the consensus panels of the International Workshop on Waldenström's Macroglobulinemia (IWWM). At IWWM-8, a task force for treatment recommendations was impanelled to review recently published and ongoing clinical trial data as well as the impact of new mutations (MYD88 and CXCR4) on treatment decisions, indications for B-cell receptor and proteasome inhibitors, and future clinical trial initiatives for WM patients. The panel concluded that therapeutic strategies in WM should be based on individual patient and disease characteristics. Chemoimmunotherapy combinations with rituximab and cyclophosphamide-dexamethasone, bendamustine, or bortezomib-dexamethasone provide durable responses and are still indicated in most patients. Approval of the BTK inhibitor ibrutinib in the United States and Europe represents a novel and effective treatment option for both treatment-naive and relapsing patients. Other B-cell receptor inhibitors, second-generation proteasome inhibitors (eg, carfilzomib), and mammalian target of rapamycin inhibitors are promising and may increase future treatment options. Active enrollment in clinical trials whenever possible was endorsed by the panel for most patients with WM. © 2016 by The American Society of Hematology.
Leblond V, Kastritis E, Advani R, Ansell SM, Buske C, Castillo JJ, García-Sanz R, Gertz M, Kimby E, Kyriakou C, et al. Treatment recommendations from the Eighth International Workshop on Waldenström's Macroglobulinemia. Blood [Internet]. 2016;128(10):1321 - 1328. WebsiteAbstract
Waldenström macroglobulinemia (WM) is a distinct B-cell lymphoproliferative disorder for which clearly defined criteria for the diagnosis, initiation of therapy, and treatment strategy have been proposed as part of the consensus panels of the International Workshop on Waldenström's Macroglobulinemia (IWWM). At IWWM-8, a task force for treatment recommendations was impanelled to review recently published and ongoing clinical trial data as well as the impact of new mutations (MYD88 and CXCR4) on treatment decisions, indications for B-cell receptor and proteasome inhibitors, and future clinical trial initiatives for WM patients. The panel concluded that therapeutic strategies in WM should be based on individual patient and disease characteristics. Chemoimmunotherapy combinations with rituximab and cyclophosphamide-dexamethasone, bendamustine, or bortezomib-dexamethasone provide durable responses and are still indicated in most patients. Approval of the BTK inhibitor ibrutinib in the United States and Europe represents a novel and effective treatment option for both treatment-naive and relapsing patients. Other B-cell receptor inhibitors, second-generation proteasome inhibitors (eg, carfilzomib), and mammalian target of rapamycin inhibitors are promising and may increase future treatment options. Active enrollment in clinical trials whenever possible was endorsed by the panel for most patients with WM. © 2016 by The American Society of Hematology.
Theodosopoulos GV, Hurley CM, Mays JW, Sakellariou G, Baskaran D. Trifunctional organolithium initiator for living anionic polymerization in hydrocarbon solvents in the absence of polar additives. Polymer Chemistry [Internet]. 2016;7:4090-4099. Publisher's VersionAbstract
A novel hydrocarbon-soluble trifunctional organolithium initiator, with no polar-additive requirements, has been synthesized for use in anionic polymerization. The complete synthesis of the unsaturated tri-diphenylethylene compound, 4,4,4-(ethane-1,1,1-triyl)tris(((3-(1-phenylvinyl)benzyl)oxy)benzene) (I), is described and the efficiency of the new initiator is evaluated using 1H NMR and Nano-assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (NALDI-TOF MS). Activation of precursor I, was performed in situ using stoichiometric amounts of sec-BuLi in benzene. Three-arm polystyrene and polyisoprene stars with narrow molecular weight distributions were obtained in the case of relatively high total anion concentration, [sec-BuLi]0 > 3.8 × 10−3 mol L−1 (3 × [I]0). At low total anion concentrations, uncontrolled molecular weight and broad/bimodal distributions were obtained, plausibly attributed to the presence of partially solvated aggregation dynamics complicating the propagation. The ‘living’ nature of the polymerization was confirmed by the sequential polymerization of styrene, and isoprene. The viscometric branching factor g’ values of the final branched polymers were measured and compared to g’ values of three-arm stars reported in the literature.
Koutsoukos K, Tzannis K, Christodoulou C, Karavasilis V, Bakoyiannis C, Makatsoris T, Papandreou CN, Pectasides D, Dimopoulos MA, Bamias A. Two cycles of adjuvant carboplatin in stage I seminoma: 8-year experience by the Hellenic Cooperative Oncology Group (HECOG). World Journal of Urology [Internet]. 2016;34(6):853 - 857. WebsiteAbstract
Purpose: Following the establishment of adjuvant carboplatin in stage I testicular seminoma as a standard, we adopted this treatment for all stage I seminoma patients. We report our 8-year experience and compare these results with our previous adjuvant etoposide/cisplatin (EP) strategy. Patients and methods: Patients with stage I seminoma, treated with adjuvant carboplatin and with a minimum follow-up of 1 year, were included. Two cycles of carboplatin [area under the curve (AUC) 6] were administered. Results: A total of 138 patients with median age of 34 years, treated from September 2003 to December 2011, were selected. There were 5 relapses [5-year relapse-free rate (RFR) 96.8 % (95 % confidence interval 91.6–98.8)]: 3 relapses at retroperitoneal lymph nodes, 1 relapse at the adrenal gland, and 1 isolated brain metastasis. Four patients with relapse were cured with salvage chemotherapy. All patients with relapse had tumor diameter ≥4 cm and/or age ≤34 years. Patients with at least 1 of the above risk factors (n = 111) had a significantly higher relapse rate compared with a similar population (n = 64) treated with 2 cycles of adjuvant EP: 5-year RFR was 95 % (SE 2 %) versus 100 % (SE 0 %), (p = 0.067). Conclusions: Age and tumor diameter were associated with relapse in stage I seminoma treated with adjuvant carboplatin. Although adjuvant carboplatin in patients with age ≤34 and/or tumor diameter ≥4 cm is associated with higher relapse rates than EP, the prognosis of these patients is excellent, and therefore, the use of less toxic treatment is justified. © 2015, Springer-Verlag Berlin Heidelberg.
Koutsoukos K, Tzannis K, Christodoulou C, Karavasilis V, Bakoyiannis C, Makatsoris T, Papandreou CN, Pectasides D, Dimopoulos MA, Bamias A. Two cycles of adjuvant carboplatin in stage I seminoma: 8-year experience by the Hellenic Cooperative Oncology Group (HECOG). World Journal of Urology [Internet]. 2016;34(6):853 - 857. WebsiteAbstract
Purpose: Following the establishment of adjuvant carboplatin in stage I testicular seminoma as a standard, we adopted this treatment for all stage I seminoma patients. We report our 8-year experience and compare these results with our previous adjuvant etoposide/cisplatin (EP) strategy. Patients and methods: Patients with stage I seminoma, treated with adjuvant carboplatin and with a minimum follow-up of 1 year, were included. Two cycles of carboplatin [area under the curve (AUC) 6] were administered. Results: A total of 138 patients with median age of 34 years, treated from September 2003 to December 2011, were selected. There were 5 relapses [5-year relapse-free rate (RFR) 96.8 % (95 % confidence interval 91.6–98.8)]: 3 relapses at retroperitoneal lymph nodes, 1 relapse at the adrenal gland, and 1 isolated brain metastasis. Four patients with relapse were cured with salvage chemotherapy. All patients with relapse had tumor diameter ≥4 cm and/or age ≤34 years. Patients with at least 1 of the above risk factors (n = 111) had a significantly higher relapse rate compared with a similar population (n = 64) treated with 2 cycles of adjuvant EP: 5-year RFR was 95 % (SE 2 %) versus 100 % (SE 0 %), (p = 0.067). Conclusions: Age and tumor diameter were associated with relapse in stage I seminoma treated with adjuvant carboplatin. Although adjuvant carboplatin in patients with age ≤34 and/or tumor diameter ≥4 cm is associated with higher relapse rates than EP, the prognosis of these patients is excellent, and therefore, the use of less toxic treatment is justified. © 2015, Springer-Verlag Berlin Heidelberg.
Lechareas S, Yanni AE, Golemati S, Chatziioannou A, Perrea DN. Ultrasound and biochemical diagnostic tools for the characterization of vulnerable carotid atherosclerotic plaque. Ultrasound Med Biol [Internet]. 2016;42(1):31-43. Publisher's VersionAbstract
Stroke is a leading cause of morbidity and mortality worldwide, and characterization of vulnerable carotid plaque remains the spearhead of scientific research. Plaque destabilization, the key factor that induces the series of events leading to the clinical symptoms of carotid artery disease, is a consequence of complex mechanical, structural and biochemical processes. Novel imaging and molecular markers have been studied as predictors of disease outcome with promising results. The aim of this review is to present the current state of research on the association between ultrasound-derived echogenicity indices and blood parameters indicative of carotid plaque stability and activity. Bibliographic research revealed that there are limited available data. Among the biomarkers studied, those related to oxidative stress, lipoproteins and diabetes/insulin resistance are associated with echolucent plaques, whereas adipokines are associated with echogenic plaques. Biomarkers of inflammation and coagulation have not exhibited any conclusive relationship with plaque echogenicity, and it is not possible to come to any conclusion regarding calcification-, apoptosis- and neo-angiogenesis-related parameters because of the extremely limited bibliographic data.
Golemati S, Gastounioti A, Nikita KS. Ultrasound-image-based cardiovascular tissue motion estimation. IEEE Rev Biomed Eng [Internet]. 2016;9:208-218. Publisher's VersionAbstract
The estimation of cardiovascular tissue motion from ultrasound images is a task of considerable importance but has remained difficult in clinical practice, mainly due to the limitations of ultrasound imaging and the complexity of tissue motion. This paper presents a survey of methodologies, along with physiologically relevant findings, regarding the estimation of motion of the myocardium and of central and peripheral arteries. Speckle tracking and modeling, and registration are the dominant methods used to calculate tissue displacements from sequences of images. Kinematic and mechanical indices are extracted from these displacements, which can provide valuable functional information about the cardiovascular system in normal and diseased conditions. An important application of motionbased strain indices involves the estimation of elastograms of the cardiovascular tissue. Motion analysis methods can be used to estimate a number of regional mechanical phenomena representing functional tissue properties, which are more sensitive to early changes due to ageing or disease. The importance of these methods lies in their potential to quantify in vivo tissue properties and to identify novel noninvasive personalized disease markers, toward early detection and optimal management of disease, along with increased patient safety. Their clinical usefulness remains to be demonstrated in larg trials.
Michopoulos S, Chouzouri VI, Manios ED, Grapsa E, Antoniou Z, Papadimitriou CA, Zakopoulos N, Dimopoulos A-M. Untreated newly diagnosed essential hypertension is associated with nonalcoholic fatty liver disease in a population of a hypertensive center. Clinical and Experimental Gastroenterology [Internet]. 2016;9:1 - 9. WebsiteAbstract
Purpose: Recent studies have demonstrated that hypertension (HTN) is associated with non- alcoholic fatty liver disease (NAFLD) in treated hypertensive patients. The aim of this study was to investigate the association between newly diagnosed essential HTN and NAFLD in untreated hypertensive patients. Patients and methods: A consecutive series of 240 subjects (143 hypertensives and 97 normotensives), aged 30-80 years, without diabetes mellitus were enrolled in the study. Subjects with 24-hour systolic blood pressure (SBP) values ≥130 mmHg and/or diastolic BP values ≥80 mmHg were defined as hypertensives. NAFLD was defined as the presence of liver hyperechogenicity on ultrasound. Results: Body mass index (P=0.002) and essential HTN (P=0.016) were independently associated with NAFLD in the multivariate logistic regression model. Furthermore, the multivariate analysis revealed that morning SBP (P=0.044) was independently associated with NAFLD. Conclusion: Untreated, newly diagnosed essential HTN is independently associated with NAFLD. Ambulatory BP monitoring could be used for the diagnosis of essential HTN in patients with NAFLD. © 2016 Michopoulos et al.
Hulin C, Belch A, Shustik C, Petrucci MT, Dührsen U, Lu J, Song K, Rodon P, Pégourié B, Garderet L, et al. Updated outcomes and impact of age with lenalidomide and low-dose dexamethasone or melphalan, prednisone, and thalidomide in the randomized, phase III FIRST trial. Journal of Clinical Oncology [Internet]. 2016;34(30):3609 - 3617. WebsiteAbstract
Purpose: This analysis of the FIRST trial in patients with newly diagnosed multiple myeloma (MM) ineligible for stem-cell transplantation examined updated outcomes and impact of patient age. Patients and Methods: Patients with untreated symptomatic MM were randomly assigned at a one-to-one-to-one ratio to lenalidomide plus low-dose dexamethasone until disease progression (Rd continuous), Rd for 72 weeks (18 cycles; Rd18), or melphalan, prednisone, and thalidomide (MPT; 72 weeks), stratified by age (≤ 75 v > 75 years), disease stage (International Staging System stage I/II v III), and country. The primary end point was progression-free survival. Rd continuous and MPT were primary comparators. Results: Between August 21, 2008, and March 7, 2011, 1,623 patients were enrolled (Rd continuous, n = 535; Rd18, n = 541; MPT, n = 547), including 567 (35%) age older than 75 years. Higher rates of advanced-stage disease and renal impairment were observed in patients older than 75 versus 75 years of age or younger. Rd continuous reduced the risk of progression or death compared with MPT by 31% (hazard ratio [HR], 0.69; 95% CI, 0.59 to 0.80; P <.001) overall, 36% (HR, 0.64; 95% CI, 0.53 to 0.77; P <.001) in patients age 75 years or younger, and 20% (HR, 0.80; 95% CI, 0.62 to 1.03; P =.084) in those age older than 75 years. Median overall survival was longer with Rd continuous than with MPT, including a 14-month difference in patients age older than 75 years. Progression-free survival with Rd18 was similar to that with MPT, and overall survival with Rd18 was marginally inferior to that with Rd continuous. Rates of grade 3 to 4 treatment-emergent adverse events were similar for Rd continuous-treated patients age 75 years or older and those age older than 75 years; however, older patients had more frequent lenalidomide dose reductions. Conclusion: Results support Rd continuous treatment as a new standard of care for stem-cell transplantation-ineligible patients with newly diagnosed MM of all ages. © 2016 by American Society of Clinical Oncology.
Hulin C, Belch A, Shustik C, Petrucci MT, Dührsen U, Lu J, Song K, Rodon P, Pégourié B, Garderet L, et al. Updated outcomes and impact of age with lenalidomide and low-dose dexamethasone or melphalan, prednisone, and thalidomide in the randomized, phase III FIRST trial. Journal of Clinical Oncology [Internet]. 2016;34(30):3609 - 3617. WebsiteAbstract
Purpose: This analysis of the FIRST trial in patients with newly diagnosed multiple myeloma (MM) ineligible for stem-cell transplantation examined updated outcomes and impact of patient age. Patients and Methods: Patients with untreated symptomatic MM were randomly assigned at a one-to-one-to-one ratio to lenalidomide plus low-dose dexamethasone until disease progression (Rd continuous), Rd for 72 weeks (18 cycles; Rd18), or melphalan, prednisone, and thalidomide (MPT; 72 weeks), stratified by age (≤ 75 v > 75 years), disease stage (International Staging System stage I/II v III), and country. The primary end point was progression-free survival. Rd continuous and MPT were primary comparators. Results: Between August 21, 2008, and March 7, 2011, 1,623 patients were enrolled (Rd continuous, n = 535; Rd18, n = 541; MPT, n = 547), including 567 (35%) age older than 75 years. Higher rates of advanced-stage disease and renal impairment were observed in patients older than 75 versus 75 years of age or younger. Rd continuous reduced the risk of progression or death compared with MPT by 31% (hazard ratio [HR], 0.69; 95% CI, 0.59 to 0.80; P <.001) overall, 36% (HR, 0.64; 95% CI, 0.53 to 0.77; P <.001) in patients age 75 years or younger, and 20% (HR, 0.80; 95% CI, 0.62 to 1.03; P =.084) in those age older than 75 years. Median overall survival was longer with Rd continuous than with MPT, including a 14-month difference in patients age older than 75 years. Progression-free survival with Rd18 was similar to that with MPT, and overall survival with Rd18 was marginally inferior to that with Rd continuous. Rates of grade 3 to 4 treatment-emergent adverse events were similar for Rd continuous-treated patients age 75 years or older and those age older than 75 years; however, older patients had more frequent lenalidomide dose reductions. Conclusion: Results support Rd continuous treatment as a new standard of care for stem-cell transplantation-ineligible patients with newly diagnosed MM of all ages. © 2016 by American Society of Clinical Oncology.
Gierens K, Eleftheratos K. Upper tropospheric humidity changes under constant relative humidity. Atmospheric Chemistry and Physics [Internet]. 2016;16:4159-4169. Publisher's Version a28_acp_2016.pdf
Bamias A, Peroukidis S, Stamatopoulou S, Tzannis K, Koutsoukos K, Andreadis C, Bozionelou V, Pistalmatzian N, Papatsoris A, Stravodimos K, et al. Utilization of Systemic Chemotherapy in Advanced Urothelial Cancer: A Retrospective Collaborative Study by the Hellenic Genitourinary Cancer Group (HGUCG). Clinical Genitourinary Cancer [Internet]. 2016;14(2):e153 - e159. WebsiteAbstract
Background Advanced urothelial cancer (AUCa) is associated with poor long-term survival. Two major concerns are related to nonexposure to cisplatin-based chemotherapy and poor outcome after relapse. Our purpose was to record patterns of practice in AUCa in Greece, focusing on first-line treatment and management of relapsed disease. Methods Patients with AUCa treated from 2011 to 2013 were included in the analysis. Fitness for cisplatin was assessed by recently established criteria. Results Of 327 patients treated with first-line chemotherapy, 179 (55%) did not receive cisplatin. Criteria for unfitness for cisplatin were: Eastern Cooperative Oncology Group (ECOG) performance status (PS) ≥ 2, 21%; creatinine clearance ≤ 60 mL/min, 55%; hearing impairment, 8%; neuropathy, 1%; and cardiac failure, 5%. Forty-six patients (27%) did not fulfill any criterion for unfitness for cisplatin. The main reasons for these deviations were comorbidities (28%) and advanced age (32%). Seventy-four (68%) of 109 patients who experienced a relapse received second-line chemotherapy. The most frequent reason for not offering second-line chemotherapy was poor PS or limited life expectancy (66%). Conclusion In line with international data, approximately 50% of Greek patients with AUCa do not receive cisplatin-based chemotherapy, although 27% of them were suitable for such treatment. In addition, about one third of patients with relapse did not receive second-line chemotherapy because of poor PS or short life expectancy. Enforcing criteria for fitness for cisplatin and earlier diagnosis of relapse represent 2 targets for improvement in current treatment practice for AUCa. © 2016 Elsevier Inc.
Bamias A, Peroukidis S, Stamatopoulou S, Tzannis K, Koutsoukos K, Andreadis C, Bozionelou V, Pistalmatzian N, Papatsoris A, Stravodimos K, et al. Utilization of Systemic Chemotherapy in Advanced Urothelial Cancer: A Retrospective Collaborative Study by the Hellenic Genitourinary Cancer Group (HGUCG). Clinical Genitourinary Cancer [Internet]. 2016;14(2):e153 - e159. WebsiteAbstract
Background Advanced urothelial cancer (AUCa) is associated with poor long-term survival. Two major concerns are related to nonexposure to cisplatin-based chemotherapy and poor outcome after relapse. Our purpose was to record patterns of practice in AUCa in Greece, focusing on first-line treatment and management of relapsed disease. Methods Patients with AUCa treated from 2011 to 2013 were included in the analysis. Fitness for cisplatin was assessed by recently established criteria. Results Of 327 patients treated with first-line chemotherapy, 179 (55%) did not receive cisplatin. Criteria for unfitness for cisplatin were: Eastern Cooperative Oncology Group (ECOG) performance status (PS) ≥ 2, 21%; creatinine clearance ≤ 60 mL/min, 55%; hearing impairment, 8%; neuropathy, 1%; and cardiac failure, 5%. Forty-six patients (27%) did not fulfill any criterion for unfitness for cisplatin. The main reasons for these deviations were comorbidities (28%) and advanced age (32%). Seventy-four (68%) of 109 patients who experienced a relapse received second-line chemotherapy. The most frequent reason for not offering second-line chemotherapy was poor PS or limited life expectancy (66%). Conclusion In line with international data, approximately 50% of Greek patients with AUCa do not receive cisplatin-based chemotherapy, although 27% of them were suitable for such treatment. In addition, about one third of patients with relapse did not receive second-line chemotherapy because of poor PS or short life expectancy. Enforcing criteria for fitness for cisplatin and earlier diagnosis of relapse represent 2 targets for improvement in current treatment practice for AUCa. © 2016 Elsevier Inc.
Siegel DS, Dimopoulos M, Jagannath S, Goldschmidt H, Durrant S, Kaufman JL, Leleu X, Nagler A, Offner F, Graef T, et al. VANTAGE 095: An International, Multicenter, Open-Label Study of Vorinostat (MK-0683) in Combination with Bortezomib in Patients with Relapsed and Refractory Multiple Myeloma. Clinical Lymphoma, Myeloma and Leukemia [Internet]. 2016;16(6):329 - 334.e1. WebsiteAbstract
Background The present global, open-label, single-arm, multicenter, phase IIb study was designed to determine the efficacy and tolerability of oral vorinostat combined with standard doses of bortezomib in patients with multiple myeloma considered refractory to novel myeloma agents. Patients and Methods Eligible patients were age ≥ 18 years, had received ≥ 2 previous regimens, had disease refractory to ≥ 1 previous bortezomib-containing regimen, and had received ≥ 1 dose of an immunomodulatory drug (thalidomide or lenalidomide)-based regimen. The patients received 21-day cycles of bortezomib (1.3 mg/m2 intravenously on days 1, 4, 8, and 11) plus oral vorinostat (400 mg/d on days 1-14). Oral dexamethasone, 20 mg, on the day of and the day after each dose of bortezomib could be added for patients with progressive disease after 2 cycles or no change after 4 cycles. The primary endpoint was the objective response rate. Results The objective response rate was 11.3% (95% confidence interval, 6.6%-17.7%), and the median duration of response was 211 days (range, 64-550 days). The median overall survival duration was 11.2 months (95% confidence interval, 8.5-14.4 months), with a 2-year survival rate of 32%. The frequently reported adverse events were thrombocytopenia (69.7%), nausea (57.0%), diarrhea (53.5%), anemia (52.1%), and fatigue (48.6%); the overall safety profile was consistent with that of bortezomib and vorinostat. Conclusion The combination of vorinostat and bortezomib is active in patients with multiple myeloma refractory to novel treatment modalities and offers a new therapeutic option for this difficult-to-treat patient population (ClinicalTrials.gov identifier, NCT00773838). © 2016 Elsevier Inc.
Siegel DS, Dimopoulos M, Jagannath S, Goldschmidt H, Durrant S, Kaufman JL, Leleu X, Nagler A, Offner F, Graef T, et al. VANTAGE 095: An International, Multicenter, Open-Label Study of Vorinostat (MK-0683) in Combination with Bortezomib in Patients with Relapsed and Refractory Multiple Myeloma. Clinical Lymphoma, Myeloma and Leukemia [Internet]. 2016;16(6):329 - 334.e1. WebsiteAbstract
Background The present global, open-label, single-arm, multicenter, phase IIb study was designed to determine the efficacy and tolerability of oral vorinostat combined with standard doses of bortezomib in patients with multiple myeloma considered refractory to novel myeloma agents. Patients and Methods Eligible patients were age ≥ 18 years, had received ≥ 2 previous regimens, had disease refractory to ≥ 1 previous bortezomib-containing regimen, and had received ≥ 1 dose of an immunomodulatory drug (thalidomide or lenalidomide)-based regimen. The patients received 21-day cycles of bortezomib (1.3 mg/m2 intravenously on days 1, 4, 8, and 11) plus oral vorinostat (400 mg/d on days 1-14). Oral dexamethasone, 20 mg, on the day of and the day after each dose of bortezomib could be added for patients with progressive disease after 2 cycles or no change after 4 cycles. The primary endpoint was the objective response rate. Results The objective response rate was 11.3% (95% confidence interval, 6.6%-17.7%), and the median duration of response was 211 days (range, 64-550 days). The median overall survival duration was 11.2 months (95% confidence interval, 8.5-14.4 months), with a 2-year survival rate of 32%. The frequently reported adverse events were thrombocytopenia (69.7%), nausea (57.0%), diarrhea (53.5%), anemia (52.1%), and fatigue (48.6%); the overall safety profile was consistent with that of bortezomib and vorinostat. Conclusion The combination of vorinostat and bortezomib is active in patients with multiple myeloma refractory to novel treatment modalities and offers a new therapeutic option for this difficult-to-treat patient population (ClinicalTrials.gov identifier, NCT00773838). © 2016 Elsevier Inc.
Malandri C, Soukis K, Maffione M, Özkaptan M, Vassilakis E, Lozios S, van Hinsbergen D. Vertical axis rotations accommodated along the ‘Mid-Cycladic Lineament’ on Paros Island in the extensional heart of the Aegean orocline (Greece). Lithosphere [Internet]. 2016;L575.1(doi:10.1130). pdfAbstract
The Aegean-west Anatolian orocline formed due to mainly post-15 Ma opposite rotations of its western and eastern limbs, which contributed to the opening of the Aegean back-arc basin. Stretching lineations in exhumed metamorphic complexes in this back-arc basin mimic the regional vertical axis rotation patterns and suggests that the oppositely rotating domains are bounded by the ‘Mid-Cycladic Lineament’, the tectonic nature of which is enigmatic. Some authors have proposed this lineament to be extensional fault accommodating orogen-parallel extension, while others considered it a transform fault. The island of Paros hosts the only exposure of the Mid-Cycladic Lineament: the northwest of the island contains E-trending and the southeast contains N trending stretching lineations. Here, we show new paleomagnetic results from isotropic, ~16 Ma granitoids that intruded both domains. These demonstrate that the trend difference resulted from post-16 Ma ~90° clockwise and 10° counterclockwise rotation of the northwest and southeast blocks, respectively. We show that a greenschist facies, semi-ductile to brittle, low-angle, southeast dipping normal fault zone, here identified as the Elitas Shear Zone that we interpret as the Mid-Cycladic Lineament accommodates this rotation difference on Paros. We conclude a two-stage exhumation history for Paros that is consistent with regional Aegean reconstructions. Between ~23 and 16 Ma, the metamorphic rocks of Paros exhumed from amphibolite-facies to greenschist facies conditions along a top-to-the-north detachment. The Elitas shear zone then started to exhume the northwestern clockwise rotating domain from below the southeastern, counterclockwise rotating domain since 16 Ma. We demonstrate at the only location at which a structure coinciding with Mid-Cycladic Lineament is exposed, it is extensional in nature, consistent with geometrical predictions that Aegean oroclinal bending must have been accommodated by combined orogen-normal and orogen-parallel extension.
Dimopoulos MA, Kastritis E, Ghobrial IM. Waldenström's macroglobulinemia: A clinical perspective in the era of novel therapeutics. Annals of Oncology [Internet]. 2016;27(2):233 - 240. WebsiteAbstract
Waldenström's macroglobulinemia (WM) is a rare, low-grade malignancy with no established standard of care. Rituximab regimens are most commonly used, supported by their efficacy in hematologic malignancies, including WM. A growing number of investigational regimens for WM have been evaluated in phase II clinical trials, including single-agent and combination strategies that include newer-generation monoclonal antibodies (ofatumumab and alemtuzumab), proteasome inhibitors (bortezomib and carfilzomib), immunomodulatory agents (thalidomide and lenalidomide), phosphoinositide 3-kinase/protein kinase B (Akt)/mammalian target of rapamycin pathway inhibitors (everolimus and perifosene), a Bruton's tyrosine kinase inhibitor (ibrutinib), and a histone deacetylase inhibitor (panobinostat). Other novel agents are in early-stage development for WM. International treatment guidelines for WM suggest suitable regimens in the newly diagnosed and relapsed/refractory settings, in accordance with patient age, disease presentation, and efficacy and safety profiles of particular drugs. These factors must be considered when choosing appropriate therapy for individual patients with WM, to maximize response and prolong survival, while minimizing the risk of adverse events. This review article provides a clinical perspective of the modern management of patients with WM, in the context of available trial data for novel regimens and recently updated treatment guidelines. © The Author 2015.
Dimopoulos MA, Kastritis E, Ghobrial IM. Waldenström's macroglobulinemia: A clinical perspective in the era of novel therapeutics. Annals of Oncology [Internet]. 2016;27(2):233 - 240. WebsiteAbstract
Waldenström's macroglobulinemia (WM) is a rare, low-grade malignancy with no established standard of care. Rituximab regimens are most commonly used, supported by their efficacy in hematologic malignancies, including WM. A growing number of investigational regimens for WM have been evaluated in phase II clinical trials, including single-agent and combination strategies that include newer-generation monoclonal antibodies (ofatumumab and alemtuzumab), proteasome inhibitors (bortezomib and carfilzomib), immunomodulatory agents (thalidomide and lenalidomide), phosphoinositide 3-kinase/protein kinase B (Akt)/mammalian target of rapamycin pathway inhibitors (everolimus and perifosene), a Bruton's tyrosine kinase inhibitor (ibrutinib), and a histone deacetylase inhibitor (panobinostat). Other novel agents are in early-stage development for WM. International treatment guidelines for WM suggest suitable regimens in the newly diagnosed and relapsed/refractory settings, in accordance with patient age, disease presentation, and efficacy and safety profiles of particular drugs. These factors must be considered when choosing appropriate therapy for individual patients with WM, to maximize response and prolong survival, while minimizing the risk of adverse events. This review article provides a clinical perspective of the modern management of patients with WM, in the context of available trial data for novel regimens and recently updated treatment guidelines. © The Author 2015.
Proias G, Nastos PT, Moustris KP, Paliatsos AG. Weekend-Weekday Effect Assessment of PM10 in Volos, Greece (2010-2014). In: {Karacostas TS, Bais AF, Nastos PT} PERSPECTIVES ON ATMOSPHERIC SCIENCES. {PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS}: {Aristotle Univ Thessaloniki, Sch Phys, Lab Atmospher Phys; Aristotle Univ Thessaloniki, Sch Geol, Dept Meteorol & Climatol; Hellen Meteorol Soc; Mariolopoulos Kanaginis Fdn Environm Sci}; 2016. pp. 957-962.Abstract
{Several epidemiological studies have shown an association between particulate air pollution and adverse health effects. The consensus among the scientific community is that suspended particulate matter is one of the most harmful pollutants, particularly the inhalable particulate matter with aerodynamic diameters less than 10 mu m (PM10) causing respiratory health effects and heart diseases. The effects of aerosols on human health are determined by both their size and their chemical composition. Average daily concentrations exceeding the EU daily threshold concentration appear, among other cases, during Sahara dust episodes, a natural phenomenon that degrades the air quality in the urban area of Volos. The city of Volos is a coastal city of medium size in the eastern seaboard of Central Greece. The main objective of this work is the study of the temporal evolution and the assessment of weekend effect in particulate matter concentration levels in the centre of the city of Volos. PM10 data obtained by a fully automated station that was established by the Hellenic Ministry of Environment and Energy, for a 5-year period (2010-2014) are analyzed in order to study the day-of-week variations during the cold and warm period of the year. As these variations are mostly expected to be due to the human working cycle, a strong weekly cycle would be indicative of the dominance of anthropogenic particles.}
Motti-Stefanidi F, Papathanasiou N, Mastrotheodoros S, Pavlopoulos V. Youth adaptation during the current great economic recession in Greece. In: Positive youth development in global contexts of social and economic change. New York, NY: Routledge; 2016. pp. 98-109. pdf
Καμπερίδου Ειρήνη. ΑΘΛΗΤΙΣΜΟΣ ΚΑΙ ΚΟΙΝΩΝΙΚΗ ΕΝΣΩΜΑΤΩΣΗ. Αναρτημένη Ανακοίνωση (με δίλεπτη προφορική παρουσίαση) στο 2ο Διεθνές Συνέδριο Αθλητικών Επιστημών, Θεσσαλονίκη 25-27 Νοεμβρίου 2016, Κέντρο Δ. 2016.Abstract
Αυτή η εργασία επικεντρώνετε στον κρίσιμο ρόλο του Αθλητισμού στην προώθηση της κοινωνικής ενσωμάτωσης: τη χρήση του αθλητισμού για την αντιμετώπιση κοινωνικών ζητημάτων που σχετίζονται με την εξάλειψη κοινωνικών διακρίσεων, τη διερεύνηση τεχνικών αντιμετώπισης συγκρούσεων και την κοινωνική ένταξη. Αρχικά, στην πρώτη ενότητα, εξετάζεται ο διεθνής διάλογος, πρόσφατα αποτελέσματα ερευνών, για κοινωνικά φαινόμενα όπως ο ρατσισμός και η ξενοφοβία. Παρατηρείτε ότι οι αντιλήψεις για τους μετανάστες και πρόσφυγες (και στη χώρα μας) προκαλούν ανησυχίες για εκείνους που ασχολούνται με την πολυπολιτισμικότητα, το σεβασμό για τα ανθρώπινα δικαιώματα, τη φυλετική και την έμφυλη πολυμορφία, την κοινωνική ισότητα και ισονομία, το νόημα του έθνους, της πατρίδας κ.ά.  Η διεθνής βιβλιογραφία δείχνει ότι όσο ισχυρότερο είναι το κοινωνικό κεφάλαιο των μεταναστών, τόσο περισσότερο διευκολύνεται η κοινωνική τους ένταξη. Τα τελευταία 25 χρόνια η Ελλάδα έχει μετατραπεί σε χώρα μαζικής υποδοχής μεταναστών. Ωστόσο, η αναγνώριση του γεγονότος ότι οι μετανάστες αποτελούν μόνιμη πραγματικότητα στη χώρα μας είναι πρόσφατη και ο δημόσιος διάλογος σχετικά με την κοινωνική και οικονομική τους ενσωμάτωση εξελίσσεται. Στη δεύτερη ενότητα διερευνάται  η χρήση του Αθλητισμού (και της φυσικής αγωγής) ως μέσου για την καλλιέργεια μιας κουλτούρας/παιδείας ειρήνης (peace education) ή ως εργαλείου για την επίλυση συγκρούσεων, ιδιαίτερα ενόψει των αυξανόμενων διαφωνιών και συγκρούσεων που σχετίζονται με τη διαχείριση της προσφυγικής κρίσης— που πλήττει κατά 60% τις γυναίκες και τα παιδιά— για την οποία κρίση η Ευρωπαϊκή Ένωση δεν έχει ολοκληρωμένη πολιτική διαχείρισης. Εντούτοις, αναδεικνύεται ότι ο Αθλητισμός μπορεί να συμβάλλει ουσιαστικά στην κοινωνική ενσωμάτωση των μεταναστών. Πρόσφατη έρευνα της Ευρωπαϊκής Επιτροπής (Σεπτ. 2016)—που συμπεριλαμβάνει 63 «καλές πρακτικές» (good practices)— τεκμηριώνει τη συμβολή του Αθλητισμού στην κοινωνική ενσωμάτωση τον μεταναστών και προσφύγων στην Ευρώπη. 
Καμπερίδου Ειρήνη. Αφηγήσεις Δυτικών Περιηγητριών του 18ου,19ου και αρχές 20ου αιώνα: «Εάν κάθε Τούρκος πασάς είχε μία Ασπασία πόσο θα βελτιωνόταν το γένος των Μ. Εισήγηση στην Ημερίδα: «Η Διάσταση του Φύλου στην Κοινωνική Πολιτική και Κοινωνιολογία», Γ’ Πάνελ. Κέντρο Πολιτισμού και Εκπαίδευσης «ΠΟΛ. 2016;(Social Policy: http://socialpolicy.gr).Abstract
Μάζης Ιωάννης. Γεωπολιτικὴ ἀνάγνωσις τοῦ Συστήματος τῆς ΝΑ Μεσογείου καὶ ἐρντογανικὸς ἀναθεωρητισμὸς. In: Ἐπιστημονικὴ Ἡμερίδα, "Ἑλλάδα -Ρωσσία: 2η χιλιετία φιλικῶν σχέσεων". Ζάππειον Μέγαρον.; 2016.Abstract
Τὸ μεσανατολικὸ γεωπολιτικὸ σύστημα, ἀναδιαρθροῦται μὲ ταχυτάτους ρυθμοὺς καὶ οἱ ἐσωτερικοὶ πυλῶνες ἰσχύος τῶν ἑκάστοτε ὑποσυστημάτων του διαμορφώνουν ἕνα πολύπλοκο δίκτυον ἀνακατανομῆς ἰσχύος ἐπηρεαζόμενομενο μὲ πρωτοφανεῖς τρόπους ἀπὸ τοὺς Πόλους Ἰσχύος τοῦ Ὑπερσυστήματος, ὅπως οἱ ΗΠΑ, ἡ Ρωσσία, ἡ Κίνα, καὶ συγκεκριμένα κράτη-μέλη τῆς Εὐρωπαϊκῆς Ἑνώσεως. Στὸ πλαίσιο αὐτὸ ἄκρως ἐνδιαφέρουσα εἶναι ἡ πλήρης ἀποτυχία τῆς ∆ημοκρατικῆς administration τῆς Οὐάσιγκτων, νὰ δημιουργήσει μίαν «ἰσλαμοδημοκρατικὴ» Τουρκία ἡ ὁποία, μὲ ἐργαλεῖον προβολῆς ἰσχύος τὴν Ὀργάνωση τῶν Ἀδελφῶν Μουσουλμάνων τῆς Αἰγύπτου, θὰ ἐλειτουργοῦσε ὡς ἰσλαμικοῦ τύπου «δημοκρατικὸ» πρότυπον διακυβερνήσεως γιὰ ὅλες τὶς ἰσλαμικοῦ πολιτισμικοῦ ὑποβάθρου χῶρες τῆς Εὐρυτέρας Μέσης Ἀνατολῆς, ἀποτελοῦσα καὶ γεωστρατηγικὸν ἀνάχωμα στὶς Μεσογειακὲς βλέψεις τῆς Ρωσσίας. Η παρούσα ομιλία αναφέρεται στη γεωπολιτικὴ ἀνάγνωση τοῦ γεωπολιτικού συστήματος τῆς ΝΑ Μεσογείου καὶ στον ἐρντογανικὸ ἀναθεωρητισμὸ.
2._xvii.pdf
Μάζης Ιωάννης. Γεωπολιτικὴ στὸν Τέταρτο Πυλῶνα: Πολιτισμός, Ἰδεολογία, Ταὐτότητες. Russia, Greece and the Mediterranean: contemporary geopolitical dynamics and perspectives of peace. 2016.Abstract
Ἡ ἀνάγνωσις τοῦ Γεωπολιτικοῦ Συμπλόκου τοῦ Εὐρω-ἀμερικανικοῦ ∆ιπόλου μὲ Γεωπολιτικὸ Παράγοντα (geopolitical factor) ἐντασσόμενο στὸν σκληρὸ πυρῆνα τοῦ Πολιτισμικοῦ Πυλῶνος (cultural pilar), τὸν παράγοντα τῆς πολιτισμικῆς ταὐτότητος, προσφέρει τὴν εἰκόνα ἑνὸς δυναμικοῦ καὶ μεταλασσόμενου γεωπολιτικοῦ πεδίου (geopolitical field), τὸ ὁποῖον παρουσιάζει κοινὰ ἐθνικο-ταὐτοτικὰ πολιτισμικὰ στοιχεῖα καὶ στρέφεται οὐσιαστικῶς ἐναντίον μιᾶς διεθνοποιημένης τραπεζικῆς πραγματικότητος μὴ βασιζομένης σὲ πραγματικὴ παραγωγὴ ἀλλὰ σὲ ἰδιαίτερα ὑψηλοὺς δεῖκτες μοχλεύσεως καὶ στὴν δημιουργία ἑνὸς Οἰκονομικοῦ ΝΑΤΟ ὑπὸ τὴν ὀνομασίαν τῆς (Transatlantic Trade and Investment Partnership) ΤΤΙP μὲ εὐρωπαῖο χειριστὴ τὴν Γερμανικὴ κυβέρνηση. Το κείμενο, εστιάζει στον τέταρτο γεωπολιτικό πυλώνα ισχύος, αυτόν του πολιτισμού.
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Ελληνική Τέχνη και Αρχαιολογία, 1200-30 π.Χ. 2nd ed. Αθήνα: Καπόν; 2016.
Καμπερίδου Ειρήνη. Ελληνισμός, Υποδούλωση, Τρομοκρατία και Δουλεία: Αφηγήσεις Δυτικών Περιηγητριών (HELLENISM, SUBJUGATION, TERRORISM AND SLAVERY: Personal Accounts by Western Women Travelers). Εισήγηση στο συνέδριο «Αθλητισμός – Πολιτισμός» του Σύνδεσμος Φιλίας Εθνών (Σ.Φ.Ε.) σε συνεργασία με τη Σχολή Επιστήμης Φυσικής Αγωγής & Αθλητισμού (Σ.Ε.Φ.Α.Α.) του Εθνικού και Καποδιστριακού Πανεπιστημίου Αθηνών (Ε.Κ.Π.Α). 2016.Abstract
© Καμπερίδου, Ειρήνη (2016) ). Ελληνισμός, Υποδούλωση, Τρομοκρατία και Δουλεία: Αφηγήσεις Δυτικών Περιηγητριών (HELLENISM, SUBJUGATION, TERRORISM AND SLAVERY: Personal Accounts by Western Women Travelers). Εισήγηση στο συνέδριο «Αθλητισμός – Πολιτισμός» του Συνδέσμου Φιλίας Εθνών (Σ.Φ.Ε.) σε συνεργασία με τη Σχολή Επιστήμης Φυσικής Αγωγής & Αθλητισμού (Σ.Ε.Φ.Α.Α.) του Εθνικού και Καποδιστριακού Πανεπιστημίου Αθηνών (Ε.Κ.Π.Α). Δάφνη, Αθήνα, 28-29 Μαΐου 2016: υπό την Αιγίδα του Εθνικού και Καποδιστριακού Πανεπιστημίου Αθηνών (ΕΚΠΑ). Επίσης, βλ.Proceedings/ Πρακτικά:   Καμπερίδου, Ειρήνη. (2016). Ελληνισμός, Υποδούλωση, Τρομοκρατία και Δουλεία: Αφηγήσεις Δυτικών Περιηγητριών. Πρακτικά- Εισηγήσεις Συνεδρίου «Αθλητισμός-Πολιτισμός» του Σύνδεσμος Φιλίας Εθνών (Σ.Φ.Ε.) σε συνεργασία με τη Σχολή Επιστήμης Φυσικής Αγωγής & Αθλητισμού (Σ.Ε.Φ.Α.Α.) του Εθνικού και Καποδιστριακού Πανεπιστημίου Αθηνών (Ε.Κ.Π.Α). © Copyright - afan.gr - Enfold Theme by Kriesi. [Πρακτικά Συνεδρίου: http://www.afan.gr/afan/%CE%B5%CE%B9%CF%83%CE%B7%CE%B3%CE%AE%CF%83%CE%B5%CE%B9%CF%82-%CF%83%CF%85%CE%BD%CE%B5%CE%B4%CF%81%CE%AF%CE%BF%CF%85-%CE%B1%CE%B8%CE%BB%CE%B7%CF%84%CE%B9%CF%83%CE%BC%CF%8C%CF%82-%CF%80%CE%BF%CE%BB/    
hellenism_subjugation_terrorism_and_slavery.pdf 2._programma_synedriou.pdf 3._poster_synedriou_a3.pdf 1._invitation.jpg.pdf hellenism_subjugation_terrorism_and_slavery_personal_accounts_by_western_women_travelers.pdf female_accounts_on_hellenism_terrorism_and_slavery.pdf athlitismos_politismos_certificate.pdf
Καμπερίδου Ειρήνη. «Επιχειρώντας Αλλιώς» στην εποχή της κρίσης: Η γυναικεία αθλητική επιχειρηματικότητα, ανεκμετάλλευτη πηγή κοινωνικού κεφαλαίου. Εισήγηση στην Ημερίδα "Γυναίκα και Αθλητισμός – Επιχειρώντας Αλλιώς", της Επιτροπής "Γυναίκα και Αθλητισμός" της Κυπριακής Ολυμπιακής Επιτ [Internet]. 2016;(9 Μαρτίου 2016 και ώρα 18.00-19.30). Publisher's VersionAbstract
When citing/ παραπομπή: ©  Καμπερίδου, Ειρήνη (2016). «Επιχειρώντας Αλλιώς» στην εποχή της κρίσης: Η γυναικεία αθλητική επιχειρηματικότητα, ανεκμετάλλευτη πηγή κοινωνικού κεφαλαίου. Εισήγηση στην ημερίδα "Γυναίκα και Αθλητισμός – Επιχειρώντας Αλλιώς" της Κυπριακής Ολυμπιακής Επιτροπής (ΚΟΕ), της Επιτροπής   "Γυναίκα και Αθλητισμός" της ΚΟΕ, υπό την αιγίδα του Υπουργείου Παιδείας και Πολιτισμού, 9 Μαρτίου 2016,  στο Ολυμπιακό Μέγαρο, αίθουσα Ευ Αγωνίζεσθαι, Λευκωσία. DOI: 10.13140/RG.2.1.5054.6322 .... [...]   Σήμερα θα προβούμε σε ένα προβληματισμό ο οποίος έχει να κάνει με τη σχέση του Αθλητισμού και το "Επιχειρείν". Δεν θα επικεντρωθούμε στη γυναικεία υποεκπροσώπηση στον επιχειρηματικό στίβο  γενικότερα,  αλλά στις ανώνυμες ηρωίδες του «αθλητικού επιχειρείν» οι οποίες σταδιακά αυξάνονται. Θα δούμε ότι η Ολυμπιακή επιχειρηματικότητα δεν αποτελεί ανδρικό φαινόμενο, επειδή ο αθλητισμός προάγει  δεξιότητες (και για τα δύο φύλα) που είναι σημαντικά για το «επιχειρείν»,  δηλαδή για την επιχειρηματικότητα και την επαγγελματική επιτυχία. Πρόσφατες έρευνες (ποιοτικές και ποσοτικές)  καθώς και συνεντεύξεις με πρώην αθλήτριες, τεκμηριώνουν ότι  ένας αθλητικός προσανατολισμός, και ειδικά ο ομαδικός αθλητισμός –ή ένα ιστορικό αθλητικής εμπειρίας— αποτελεί χρήσιμο εργαλείο, όσον αφορά στην επιχειρηματικότητα και ειδικά όσον αφορά στην καλλιέργεια και ανάπτυξη ηγετικών δεξιοτήτων, όπως ένα πειθαρχημένο εργασιακό ήθος … … Λέξεις κλειδιά-  Επιχειρηματικότητα (entrepreneur, entrepreneurship), φύλο (gender), αθλητισμός,  φυσική αγωγή, αρχηγία, εξουσία,  ολιστική προσέγγιση: κουλτούρα συνεργασίας,  ηγεσία (εμπνέω, συντονίζω, καθοδηγώ), η πρώτη γυναίκα Ολυμπιακή επιχειρηματίας (Olympic entrepreneur: Alice Milliat) ** http://balla.com.cy/2016/03/10/imerida-ginaikas/ http://24h.com.cy/2016/03/07/hmerida-me-thema-gynaika-kai-athlitismos-epihirontas-allios-dia/
cyprus_olympic_committee_letter_and_invitation.pdf cyprus_olympic_committee_epiheirontas_allios_march_3-2016._final.pdf
Μάζης Ιωάννης. Ἡ Γεωπολιτικὴ τῆς Ὀρθοδοξίας: Τὸ «Εἶναι» καὶ τὸ «Πρέπει». Ἐπιθεώρησις «Πανόραμα» τῆς Ἑλληνορωσσικῆς Λέσχης ∆ιάλογος. 2016.Abstract
Στο παρόν κείμενο εξετάζονται τρεις υποθέσεις: α) η υπόθεσις όπου η Ρωσία κατισχύει δια του Πατριαρχείου της επί του Ορθοδόξου Χριστιανικού κόσμου, γεγονός το οποίο συνεπάγεται τη θραύση του Rimland στον άξονα Βαλκανικής Χερσονήσου-Μεσογείου, β) η υπόθεσις όπου το δίπολο Λονδίνου-Ουάσινγκτον συνεχίζει δια του Οικουμενικού Πατριαρχίου τον έλεγχον της εξόδου της Μόσχας στη Μεσόγειο και γ) η υπόθεσις όπου η Μόσχα και η Ουάσινγκτον συγκλίνουν για την αντιμετώπιση της κινεζικής προβολής ισχύος στην Μεσόγειο και όχι μόνον.
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Κουκουνάρας- Λιάγκης Μάριος. Η εκπαιδευτική αξία των επιτραπέζιων παιχνιδιών στη διδασκαλία στο Γυμνάσιο. Μελέτη περίπτωσης στο πλαίσιο της Θρησκευτικής Εκπαίδευσης. Πρακτικά Εργασιών 1ου Διεθνούς Βιωματικού Συνεδρίου Εφαρμοσμένης Διδακτικής "Καινοτόμες Εφαρμογές στη Διδακτική Πράξη". 2016:446-454. i_ekpaideytiki_axia_ton_epitrapezion_paihnidion_sti_didaskalia_sto_gymnasio._meleti_periptosis_sto_plaisio_tis_thriskeytikis_ekpaideysis.pdf
Kaili H, Spyropoulos V. Η επίδραση της Ελληνικής στην τουρκική ποικιλία της δίγλωσσης στην Ελληνική και Τουρκική μουσουλμανικής κοινότητας της Ρόδου [The impact of Greek on the Turkish variety of the Greek and Turkish bilingual muslim community of Rhodes]. In: Γλωσσική και Κοινοτική Ετερότητα στη Δωδεκάνησο του 20ου Αιώνα [Language and Community Diversity in 20th century Dodecanese]. Athens: Papazisis; 2016. pp. 329-359.
Κουκουνάρας- Λιάγκης Μάριος. Η θέση της Θρησκευτικής Εκπαίδευσης στο ελληνικό σχολείο του 21ου αιώνα: ζητήματα υποχρεωτικότητας, προγράμματος σπουδών και παιδαγωγικής προσέγγισης. 1ο Πανελλήνιο Συνέδριο "Προγράμματα Σπουδών - Σχολικά εγχειρίδια: Από το παρελθόν στο παρόν και το μέλλον". 2016:201-212. _._201.pdf
"Ξεθάβουν τώρα τα αγάλματα": οι αισθητήριες αρχαιολογίες του Γιώργου Σεφέρη. In: Τιμητικός Τόμος για τη Στέλλα Δρούγου. Αθήνα: Ταμείο Αρχαιολογικών Πόρων και Απαλλοτριώσεων; 2016. pp. 348-368. Publisher's VersionAbstract
In June 1946 George Seferis, the eminent Greek poet who was goingto become the Nobel-laureate patriarch of Greek modernist poetry by1963, witnessed the re-excavation of the statues and vases until thenhidden in the vaults of the National Museum in Athens in order toprevent their damage, or looting, by the Germans during the occupation.As he observes the bronze statue of Zeus, a fifth-century BC work thatis still considered one of the masterpieces in the Museum’s collectionand of Greek art at large, the poet fantasizes the god’s lovemaking witha woman whom Seferis himself “would love”, as he unashamedly informsus in his diary from that day. In the paper, I use the concept ofhomosociality in order to explore the ways in which Seferis and manyof his contemporaries view classical antiquity and proceed to deploy itas a bio-political tool in order to claim a centralized role in Greekintellectual and political life. To this end, I re-visit Seferis’s two chief“archaeological” poems –The King of Asine and Engomi – in an effortto investigate the ways in which his sensory archaeologies manifestthemselves.
Kamberidou I. Σύγχρονη Γυναίκα και Άθληση: Συμμετοχή, Προκλήσεις, Προοπτικές. Συμμετοχή στο ΣΥΜΠΟΣΙΟ με τίτλο: «Σύγχρονη Γυναίκα και Άθληση: Συμμετοχή, Προκλήσεις, Προοπτικές», διοργάνωση η Πανελλήνια Ένωση για την Πρ. 2016;(Αριστοτελείου Πανεπιστημίου Θεσσαλονίκης).Abstract
Συμμετοχή στο ΣΥΜΠΟΣΙΟ με τίτλο: «Σύγχρονη Γυναίκα και Άθληση: Συμμετοχή, Προκλήσεις, Προοπτικές» της Πανελλήνιας Ένωσης για την Προώθηση των Γυναικών στον Αθλητισμό και τα Σπορ (ΠΕΠΓΑΣ) της Σχολής Επιστημών Φυσικής Αγωγής και Αθλητισμού του Αριστοτελείου Πανεπιστημίου Θεσσαλονίκης (ΑΠΘ), 25/11/2016, στο ΚΕΔΕΑ/Α.Π.Θ. [Επισυνάπτεται βεβαίωση συμμετοχής] Προσκεκλημένη στο πραναφερόμενο συμπόσιο μετά την προφορική ανακοίνωσή:Καμπερίδου, Ειρήνη. (2016). ΦΥΛΟ ΚΑΙ ΗΓΕΤΙΚΕΣ ΔΕΞΙΟΗΤΕΣ: ΤΟ ΑΘΛΗΤΙΚΟ ΕΠΙΧΕΙΡΕΙΝ. Προφορική Ανακοίνωση στο 2ο Διεθνές Συνέδριο Αθλητικών Επιστημών, Θεσσαλονίκη 25-27 Νοεμβρίου 2016, Κέντρο Διάδοσης Ερευνητικών Αποτελεσμάτων (ΚΕΔΕΑ). Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ). Copy at http://www.tinyurl.com/gtggejd 
women_and_sport_symposium.jpg pepgas.jpg 20161125_131304-1.jpg 20161125_123045-4.jpg 20161125_121711-3.jpg 20161125_115500.jpg pepgas_the_new_generation.jpg rector.jpg
Το Πρόσφατο Μέλλον. Η Κλασική Αρχαιότητα ως Βιοπολιτικό Εργαλείο. Αθήνα: Νεφέλη; 2016. Publisher's Version
Καμπερίδου Ειρήνη. ΦΥΛΟ ΚΑΙ ΗΓΕΤΙΚΕΣ ΔΕΞΙΟΗΤΕΣ: ΤΟ ΑΘΛΗΤΙΚΟ ΕΠΙΧΕΙΡΕΙΝ. Προφορική Ανακοίνωση στο 2ο Διεθνές Συνέδριο Αθλητικών Επιστημών, Θεσσαλονίκη 25-27 Νοεμβρίου 2016, Κέντρο Διάδοσης Ερευνητικών Αποτελεσμάτων (ΚΕΔΕΑ). 2016.Abstract
Ερευνητικά δεδομένα τεκμηριώνουν ότι οι γυναίκες βρίσκονται ένα βήμα μπροστά από τους άντρες αναφορικά με κάποιες δεξιότητες, αποκαλούμενες στο παρελθόν «γυναικείες αρετές» ή «θηλυκές δεξιότητες» τις οποίες υιοθετούν όλο και περισσότεροι άνδρες επιχειρηματίες και στελέχη επιχειρήσεων σήμερα. Έρευνες που αφορούν την παραγωγικότητα δείχνουν ότι εταιρείες που απασχολούν και προωθούν γυναίκες σε ηγετικούς ρόλους εμφανίζουν, κατά μέσο όρο, περισσότερα κέρδη και μεγαλύτερη βιωσιμότητα. Με βάση τα αποτελέσματα μιας σχετικής με το ζήτημα φύλο και επιχειρηματικότητα ποιοτικής έρευνας, η μελέτη αυτή στοχεύει να αναδείξει σημαντικούς συσχετισμούς μεταξύ αθλητικής εμπειρίας και πετυχημένης επιχειρηματικότητας. Ερευνητικά στοιχεία τεκμηριώνουν ότι ένα ιστορικό αθλητικής εμπειρίας, ειδικά η συμμετοχή σε ομαδικά αθλήματα, αποτελεί χρήσιμο εργαλείο όσον αφορά στην καλλιέργεια ηγετικών δεξιοτήτων και στην ανέλιξη επιχειρηματικών δράσεων. Σχετικές έρευνες και συνεντεύξεις που πραγματοποιήθηκαν με εν ενεργεία και πρώην αθλήτριες, πρωταθλήτριες και ολυμπιονίκες πιστοποιούν ότι ο αθλητισμός προάγει δεξιότητες που είναι σημαντικές για το επιχειρείν. Θεωρείται ότι η αθλητική επιχειρηματικότητα αποτελεί ανδρικό φαινόμενο. Ωστόσο, Ελληνίδες αθλήτριες, γυμνάστριες, επιχειρηματίες και ακτιβίστριες που έχουν διαπρέψει στο αθλητικό επιχειρείν, μετά από σειρά συνεντεύξεων, μας παρέχουν πολύτιμες συμβουλές (tips-μέθοδοι-εργαλεία ενδυνάμωσης δεξιοτήτων) για επαγγελματική επιτυχία.     [Proceedings page 68—Πρακτικά 2ου Διεθνούς Συνεδρίου Αθλητικών Επιστημών (ICSS 2016) http://icss2016.web.auth.gr/el/proceedings/icss2016 (σελίδα 68) ]  
gender_and_leadershop_skills-_sport_entrepreneurship.pdf 2nd_int._conference.vevaiosi_omilias_presentation_certification.jpg diploma.jpg sport_entrepreneushp_leadership_certificate.pdf sport_science_conf._thessaloniki_nov._2016.pdf pepgas_nov._2016.pdf
Καμπερίδου Ειρήνη, Kamberidou I. Φύλο και Ηγετικές Δεξιότητες: Γεφυρώνοντας το Έμφυλο Χάσμα (Gender and Leadership Skills: Bridging the Gender Gap). LWB-Leading Women in Business. Κεφάλαιο: Αρθρογραφία Επιφανών Λειτουργών και της ICAP για τη Γυναικεία Επιχειρηματικότητα. 2016:98-99.Abstract
Καμπερίδου, Ειρήνη (2017). Φύλο και Ηγετικές Δεξιότητες: Γεφυρώνοντας το Έμφυλο Χάσμα. LWB-Leading Women in Business, σελ. 98-99.  Κεφάλαιο: Αρθρογραφία Επιφανών Λειτουργών και της ICAP για τη Γυναικεία Επιχειρηματικότητα.  Εκδότης: ΙCAP GROUP Α.Ε. ISSN 2241-4126  [e-book: http://dir.icap.gr/mailimages/e-books/LWB/index.html]    Η διανομή της έκδοσης πραγματοποιήθηκε αρχικά με «ΤΑ ΝΕΑ του Σαββατοκύριακου» στην Αττική (πριν την Πρωτοχρονιά, 30/12/2016) και με τη «ΜΑΚΕΔΟΝΙΑ» (σε CD) στη Θεσσαλονίκη. Επιπρόσθετα, θα μοιραστεί στην επίσημη εκδήλωση “High Heels on High Hills” το 2017 και σε άλλες εκδηλώσεις που διοργανώνει ή συμμετάσχει η ICAP.  Τέλος, θα διανεμηθεί σε φορείς της γυναικείας επιχειρηματικότητας (σε Αττική και Βόρεια Ελλάδα), καθώς και σε 2.000 εταιρείες και ακαδημαϊκά ιδρύματα, ως χρηστικό εργαλείο επί των εργασιών τους............................................. Kamberidou, Irene (2016). Gender and Leadership Skills: Bridging the Gender Gap, pp. 98-99 in LWB-Leading Women in Business. Publisher:  ICAP GROUP A.E. ISSN 2241-4126  [e-book: http://dir.icap.gr/mailimages/e-books/LWB/index.html]  The book circulated, for the first time on Dec. 30, 2016 in Athens with the daily newspaper TA NEA, and as a CD in Thessaloniki with the daily MACEDONIA. It will also be distributed at the 2017 “High Heels on High Hills” and other events and conferences organized by the ICAP Group. To assist researchers, students and entrepreneurs it will also be sent to 2.000 companies and academic institutions throughout Greece.
leading_women_in_business_dec.30_2016_icap_2016.pdf gender_and_leadership_skills._icap_2016.pdf icap_2017.pdf
Mazis I. ВАРИАНТ «БЕШЕНОЙ» ПЕШКИ Кто поставит мат в сложной гроссмейстерской игре на «Великой шахматной доске» Ближнего Востока?. 2016.Abstract
Ответный ход Путина: господин Путин, однако, хочет поставить мат НАТО, и если понадобится, он с готовностью принесет в жертву «сумасшедшего». Это является единственным ходом, доступным Путину: он требует, чтобы Турция максимально быстро вышла из НАТО! В противном случае Эрдоган станет разменной монетой! Дилемма: примет ли или нет господин Эрдоган требование Путина, в конце этой истории его ждет Большой Курдистан. Разница заключается лишь в том, что, если он примет предложение Путина, то обеспечит себе пожизненный отпуск на даче, где-то в Крыму или в Сочи, покинув Турцию навсегда. В противоположном случае, впрочем, его ждет вилла в Саудовской Аравии! Его место почти наверняка займут «запасные политики» вроде Абдуллы Гюля или Ахмета Давутоглу, причем Турция останется инструментом США в «Евразийских Балканах». В обоих случаях обе супердержавы выигрывают: а) 50% территории через создаваемый Большой Курдистан б) развертывание сил на ближний средний восток в) богатые ресурсы г) Сирия получает небольшую долю от выигрыша США, России и Израиля. Партия Путин-США, похоже, заканчивается вничью. Однако нет, поскольку господин Путин серьезно нарастил противостояние юго-восточному крылу НАТО и перераспределил мощности на Ближнем и Среднем Востоке, наращивая несущественное, до недавнего времени, присутствие его сил на этой территории, путем пожертвования «бешеной пешки» в Ближневосточной шахматной игре.
lxviii._variant_beshenoy_peshki_kto_postavit_mat_v_slozhnoy_grossmeysterskoy_igre_na_velikoy_shahmatnoy_doske_blizhnego_vostoka.pdf
2015
Chatziioannou S, Papamichos O, Gamaletsou MN, Georgakopoulos A, Kostomitsopoulos NG, Tseleni-Balafouta S, Papaparaskevas J, Walsh TJ, Pneumaticos SG, Sipsas NV. 18-Fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography scan for monitoring the therapeutic response in experimental Staphylococcus aureus foreign-body osteomyelitis. J Orthop Surg Res. 2015;10:132.Abstract
BACKGROUND: 18-Fluoro-2-deoxy-D-glucose positron emission tomography combined with computed tomography ((18)F-FDG PET/CT) scan is useful for diagnosis of osteoarticular infections. Whether (18)F-FDG PET/CT scanning may be used for therapeutic monitoring is not clear. The objective of this study was to develop (18)F-FDG PET/CT scanning for monitoring therapeutic response to antimicrobials in experimental Staphylococcus aureus osteomyelitis. METHODS: A total of 22 rabbits were studied. In 20 animals, the right tibia was inoculated intraoperatively with S. aureus. Two control animals were inoculated with normal saline. A needle was placed in the tibia as a foreign body. Infection was allowed to develop for 21 days when (18)F-FDG PET/CT was performed, the needle was removed, and bone specimens were cultured to confirm infection. Antimicrobial therapy with daptomycin was initiated in all successfully infected animals for 1, 3, or 6 weeks. Following completion of treatment, a second (18)F-FDG PET/CT was performed, animals were euthanized, and infected tibias were harvested for quantitative cultures and histology. A positive scan was defined as (18)F-FDG signal activity greater in the infected tibia than that of the contralateral non-infected control tibia. Therapeutic response was measured by the change of (18)F-FDG signal activity in the infected tibia. RESULTS: All successfully infected animals (n = 14), with microbiologically and/or histologically confirmed osteomyelitis, had positive (18)F-FDG PET/CT scans, while the two control animals had negative scans despite the presence of the foreign body [mean maximum standardized uptake value (SUVmax) (±SD) values 2.96 (±0.80) vs. 1 (±1.10), respectively, P = 0.04]. In the 14 successfully infected animals, the mean SUVmax was significantly higher in the infected compared to the uninfected tibia (P < 0.0001). A SUVmax of 1.4, when used as a cutoff for infection, yielded a diagnostic accuracy of 93 %. At the end of treatment, successfully treated animals and saline controls had a negative (18)F-FDG PET/CT scan (n = 4), while animals with persistent infection despite treatment (n = 12) had a positive (18)F-FDG PET/CT scan (SUVmax 1.0-3.0) (p < 0.001). SUVmax values were significantly reduced after 42 days of treatment from 3.15 ± 0.5 (day 7) to 1.71 ± 0.37 (day 42) (p = 0.05). CONCLUSIONS: (18)F-FDG PET/CT scan is a sensitive and specific tool in therapeutic monitoring of experimental foreign-body osteomyelitis.
1915-2015: μια ιστορική-επιστημολογική αποτίμηση της θεωρίας της σχετικότητας. Η ΕΦΗΜΕΡΙΔΑ ΤΩΝ ΣΥΝΤΑΚΤΩΝ [Internet]. 2015;(12-13 Δεκεμβρίου):78-79. Publisher's Version
Vlahakos DV, Dalamaga M, Marouga A, Bacharaki D, Drakou A, Dimas C. 1C.09: SERUM RESISTIN AS AN INDEPENDENT BIOMARKER ASSOCIATED WITH ALL-CAUSE AND CARDIOVASCULAR MORTALITY IN ELDERLY HYPERTENSIVE, NON-DIABETIC PATIENTS WITH CHRONIC KIDNEY DISEASE (CKD). J Hypertens. 2015;33 Suppl 1:e11-2.Abstract
OBJECTIVE: Hypertensive patients with CKD present an increased risk for cardiovascular mortality. Among the proteins synthesized and released from adipose tissue, resistin is a cytokine whose physiologic role has been the subject of much research and controversy. We and others have demonstrated that serum resistin levels are higher in patients with CKD and correlate directly with inflammatory markers, including TNF-α and hsCRP. Since inflammation has been consistently linked to atherosclerosis, death, and cardiovascular (CV) events, our goal was to investigate the interaction between resistin levels and long term all-cause and CV mortality in elderly non-obese and non-diabetic with hypertension. DESIGN AND METHOD: We studied 80 patients (52 men/28 women) 70.9 ± 8.6 years of age with hypertension and CKD. Exclusion criteria was obesity and diabetes mellitus, active infection, acute illness, chronic inflammatory disease or cancer, and immunosuppresive, anti-inflammatory or anti-lipidemic drugs. Demographic data, clinical information and blood samples were collected prospectively. The patients were observed for 5 years. RESULTS: During the follow-up 28 of 80 (35%) patients died: 16 (57%) deaths due to CV events and 12 (43%) of other causes. Patients who died were older and had higher DBP, compared to survivors, but had no differences in BMI, smoking, SBP and HR. Deceased patients had higher WBC, hsCRP, BUN, creatinine, cystatin C, phosphate, magnesium and potassium levels and lower eGFR, Hct/Hg, T3, T4, total cholesterol, LDL-C, albumin and sodium levels compared to survivors. No significant differences in platelet count, TNF-α, fibrinogen, oxLDL, ADMA, HgA1C and HOMA-index were revealed between the groups. eceased patients had significantly higher resistin levels than survivors at baseline (p = 0.025), but adiponectin, visfatin and leptin did not differ between the two groups. Five variables, namely resistin, sodium, cholesterol, T3 and WBC remained significantly associated with survival and were used in the multivariate Cox regression analysis, which revealed that only resisitin, cholesterol and WBC maintained their discriminatory ability, as independent predictors of mortality both by forward and backward stepwise analysis. CONCLUSIONS: Elevated serum resistin was a significant independent biomarker of CV and all-cause mortality in elderly, non-diabetic CKD patients with hypertension.
Cox P, Foster A, Hargitai B, Konstantinidou A, Marton T. 26. The Spectrum of Cardiac Pathology in Fetal Hydrops due to Noonan syndrome. Pediatric & Developmental Pathology. 2015;18(2):e48.
Vrontaki E, Melagraki G, Afantitis A, Tsantili-Kakoulidou A, Mavromoustakos T. 3D quantitative structure - Activity relationships (3D - QSAR): A short overview. Pharmakeftiki [Internet]. 2015;27(4):126 - 137. Website
Stefanou DT, Bamias A, Episkopou H, Kyrtopoulos SA, Likka M, Kalampokas T, Photiou S, Gavalas N, Sfikakis PP, Dimopoulos MA, et al. Aberrant dna damage response pathways may predict the outcome of platinum chemotherapy in ovarian cancer. PLoS ONE [Internet]. 2015;10(2). WebsiteAbstract
Ovarian carcinoma (OC) is the most lethal gynecological malignancy. Despite the advances in the treatment of OC with combinatorial regimens, including surgery and platinum-based chemotherapy, patients generally exhibit poor prognosis due to high chemotherapy resistance. Herein, we tested the hypothesis that DNA damage response (DDR) pathways are involved in resistance of OC patients to platinum chemotherapy. Selected DDR signals were evaluated in two human ovarian carcinoma cell lines, one sensitive (A2780) and one resistant (A2780/C30) to platinum treatment as well as in peripheral blood mononuclear cells (PBMCs) from OC patients, sensitive (n = 7) or resistant (n = 4) to subsequent chemotherapy. PBMCs from healthy volunteers (n = 9) were studied in parallel. DNA damage was evaluated by immunofluorescence ãH2AX staining and comet assay. Higher levels of intrinsic DNA damage were found in A2780 than in A2780/C30 cells. Moreover, the intrinsic DNA damage levels were significantly higher in OC patients relative to healthy volunteers, as well as in platinum-sensitive patients relative to platinum-resistant ones (all P <0.05). Following carboplatin treatment, A2780 cells showed lower DNA repair efficiency than A2780/ C30 cells. Also, following carboplatin treatment of PBMCs ex vivo , the DNA repair efficiency was significantly higher in healthy volunteers than in platinum-resistant patients and lowest in platinum-sensitive ones (t1/2 for loss of ãH2AX foci: 2.7± 0.5h, 8.8±1.9h and 15.4±3.2h, respectively; using comet assay, t1/2 of platinum-induced damage repair: 4.8±1.4h, 12.9±1.9h and 21.4±2.6h, respectively; all P<0.03). Additionally, the carboplatin-induced apoptosis rate was higher in A2780 than in A2780/C30 cells. In PBMCs, apoptosis rates were inversely correlated with DNA repair efficiencies of these cells, being significantly higher in plati-num-sensitive than in platinum-resistant patients and lowest in healthy volunteers (all P< 0.05). We conclude that perturbations of DNA repair pathways as measured in PBMCs from OC patients correlate with the drug sensitivity of these cells and reflect the individualized response to platinum-based chemotherapy. © 2015 Stefanou et al.
Dalamaga M, Christodoulatos GS. Adiponectin as a biomarker linking obesity and adiposopathy to hematologic malignancies. Horm Mol Biol Clin Investig. 2015;23(1):5-20.Abstract
Higher body mass index and adiposopathy have been associated with increased risk of hematologic malignancies such as leukemia, multiple myeloma, myeloproliferative disorders, Hodgkin's and non-Hodgkin's lymphoma, and myelodysplastic syndromes. Adiponectin is a multimeric protein of the white adipose tissue presenting anti-inflammatory, insulin-sensitizing, anti-atherogenic, cardioprotective, and anti-neoplastic properties. Its anti-neoplastic actions are manifested via two mechanisms: (i) direct action on tumor cells by enhancing receptor-mediated signaling pathways and (ii) indirect action by regulating inflammatory responses, influencing cancer angiogenesis, and modulating insulin sensitivity at the target tissue site. In the bone marrow milieu, adiponectin and its main receptors are expressed by the majority of bone marrow stromal cell populations influencing hematopoietic stem cells function. Adiponectin may represent a molecular mediator relating adiposopathy with leukemogenesis and myelomagenesis. Several epidemiological studies conducted to date relate hypoadiponectinemia to the risk of myeloid-derived hematopoietic cancer and multiple myeloma. Adiponectin may be a promising biomarker with potential diagnostic and prognostic utility in determining the likelihood of myeloma and leukemia progression in certain cohorts of monoclonal gammopathy of undetermined significance patients and in myeloid hematologic malignancies, respectively. This review summarizes experimental and epidemiologic data regarding the role of adiponectin in hematologic malignancies in the context of adiposopathy. Enhancement of endogenous adiponectin, adiponectin replacement, or manipulation of adiponectin receptor sensitivity may be an attractive goal for prevention and an effective therapeutic strategy against hematopoietic cancer, specifically in overweight/obese individuals. Further studies are required to elucidate the role of the bone marrow microenvironment adiponectin in complex interactions involved in preleukemic and leukemic states.
Vrachatis DA, Papaioannou TG, Vavuranakis M, Tousoulis D. Advances in intra-arterial counterpulsation: The role of in vitro studies. Archives of Hellenic Medicine [Internet]. 2015;32(4):433 - 440. Website
Nastos P, Matzarakis A, Nikolopoulou M, Lin T-P. Advances in urban biometeorology 2014. Advances in Meteorology [Internet]. 2015;2015. Website
Psaltopoulou T, Sergentanis TN, Sergentanis IN, Karadimitris A, Terpos E, Dimopoulos MA. Alcohol intake, alcoholic beverage type and multiple myeloma risk: A meta-analysis of 26 observational studies. Leukemia and Lymphoma [Internet]. 2015;56(5):1484 - 1501. WebsiteAbstract
This meta-analysis aimed to examine the association between alcohol consumption and multiple myeloma (MM) risk. Eligible publications were sought in PubMed to 31 December 2013. Separate analyses were performed by study design, gender, alcoholic beverages and levels of consumption. Sixteen case-control studies (3921 cases and 19 594 controls) and 10 cohort studies (3167 incident cases in total cohort of 2 557 649 subjects) were eligible. Ever consumption of alcohol was associated with reduced MM risk (pooled relative risk [RR] = 0.88, 95% confidence interval [CI]: 0.79-0.99) and especially consumption of wine correlated with reduced MM risk (pooled RR = 0.77, 95% CI: 0.67-0.89 for ever drinkers). MM risk was not affected by beer or liquor intake. A protective association was observed among females (pooled RR = 0.79, 95% CI: 0.69-0.89 for ever drinkers), whereas the association among males seemed null. In conclusion, contrary to most solid tumors, alcohol intake may confer protection in terms of MM risk among females, with wine being particularly beneficial. © 2014 Informa UK, Ltd.
Tsabouri S, Bleta AG, Nastos PT, Priftis KN. Ambient environmental risk factors for childhood wheezing illness. Frontiers in Bioscience - Elite [Internet]. 2015;7E(3):447 - 468. WebsiteAbstract
It is a great consensus in the scientific community that environmental factors, such as weather conditions and ambient air pollution, have vital impacts on respiratory diseases. Further, these factors imply the potential to have many significant impacts on aeroallergens, and therefore related diseases such as asthma and allergic rhinitis. The impacts are more pronounced in sensitive groups of population, such as children and elderly, living in urbanized areas. Over the last three decades, studies have shown changes in production, dispersion and allergen content of pollen and spores, which may be region- and species-specific. In addition, these changes may have been influenced by air pollutants interacting directly with pollen. It is not easy to evaluate the impact of climate change and air pollution on the prevalence of asthma in general and on the timing of asthma exacerbations. However, the global rise in asthma prevalence and severity suggests that air pollution and climate changes could be contributing. The objective of this review is to summarize the environmental impacts on pulmonary diseases in children based on recent literature over the world. © 2015, Frontiers in Bioscience. All rights reserved.
Giralt S, Garderet L, Durie B, Cook G, Gahrton G, Bruno B, Hari P, Lokhorst H, McCarthy P, Krishnan A, et al. American Society of Blood and Marrow Transplantation, European Society of Blood and Marrow Transplantation, Blood and Marrow Transplant Clinical Trials Network, and International Myeloma Working Group Consensus Conference on Salvage Hematopoietic Cell Tra. Biology of Blood and Marrow Transplantation [Internet]. 2015;21(12):2039 - 2051. WebsiteAbstract
In contrast to the upfront setting in which the role of high-dose therapy with autologous hematopoietic cell transplantation (HCT) as consolidation of a first remission in patients with multiple myeloma (MM) is well established, the role of high-dose therapy with autologous or allogeneic HCT has not been extensively studied in MM patients relapsing after primary therapy. The International Myeloma Working Group together with the Blood and Marrow Transplant Clinical Trials Network, the American Society of Blood and Marrow Transplantation, and the European Society of Blood and Marrow Transplantation convened a meeting of MM experts to: (1) summarize current knowledge regarding the role of autologous or allogeneic HCT in MM patients progressing after primary therapy, (2) propose guidelines for the use of salvage HCT in MM, (3) identify knowledge gaps, (4) propose a research agenda, and (5) develop a collaborative initiative to move the research agenda forward. After reviewing the available data, the expert committee came to the following consensus statement for salvage autologous HCT: (1) In transplantation-eligible patients relapsing after primary therapy that did NOT include an autologous HCT, high-dose therapy with HCT as part of salvage therapy should be considered standard; (2) High-dose therapy and autologous HCT should be considered appropriate therapy for any patients relapsing after primary therapy that includes an autologous HCT with initial remission duration of more than 18 months; (3) High-dose therapy and autologous HCT can be used as a bridging strategy to allogeneic HCT; (4) The role of postsalvage HCT maintenance needs to be explored in the context of well-designed prospective trials that should include new agents, such as monoclonal antibodies, immune-modulating agents, and oral proteasome inhibitors; (5) Autologous HCT consolidation should be explored as a strategy to develop novel conditioning regimens or post-HCT strategies in patients with short (less than 18 months remissions) after primary therapy; and (6) Prospective randomized trials need to be performed to define the role of salvage autologous HCT in patients with MM relapsing after primary therapy comparing it to "best non-HCT" therapy. The expert committee also underscored the importance of collecting enough hematopoietic stem cells to perform 2 transplantations early in the course of the disease. Regarding allogeneic HCT, the expert committee agreed on the following consensus statements: (1) Allogeneic HCT should be considered appropriate therapy for any eligible patient with early relapse (less than 24 months) after primary therapy that included an autologous HCT and/or high-risk features (ie, cytogenetics, extramedullary disease, plasma cell leukemia, or high lactate dehydrogenase); (2) Allogeneic HCT should be performed in the context of a clinical trial if possible; (3) The role of postallogeneic HCT maintenance therapy needs to be explored in the context of well-designed prospective trials; and (4) Prospective randomized trials need to be performed to define the role salvage allogeneic HCT in patients with MM relapsing after primary therapy. © 2015 American Society for Blood and Marrow Transplantation.
Lantzouraki, D.Z. SZGĆSHPVJPG. Antiradical-antimicrobial activity and phenolic profile of pomegranate (Punica granatum L.) juices from different cultivars: A comparative study. RSC Advances [Internet]. 2015;5:2602-2614. Website
Kastritis E, Dimopoulos MA. Appraising myc involvement in high risk myeloma. Leukemia and Lymphoma [Internet]. 2015;56(3):551 - 552. Website
Kopanias K, MacGinnis J, Ur J. Archaeological Projects in the Kurdistan Region in Iraq. Α Gazeteer. Erbil: General Directorate of Antiquities in the Kurdistan Region in Iraq; 2015. Website
Zagouri F, Sergentanis TN, Azim, H.A. J, Chrysikos D, Dimopoulos M-A, Psaltopoulou T. Aromatase inhibitors in male breast cancer: a pooled analysis. Breast Cancer Research and Treatment [Internet]. 2015;151(1):141 - 147. WebsiteAbstract
Although several studies have shown the efficacy of third-generation aromatase inhibitors (AIs) in women with breast cancer, the role of such molecules remains elusive in male breast cancer patients. It is also unknown whether the addition of gonadotropin-releasing hormone (GnRH) analogues to AIs would be a superior strategy or not. This pooled analysis was conducted in accordance with the PRISMA guidelines. All studies that examined the efficacy of AIs in metastatic male breast cancer were considered eligible. Overall, 15 studies (105 cases) were eligible for this pooled analysis. The mean age of the study sample was 62.8 years. ER status was positive in all eligible cases. AI was given as first line in 61.5 % of cases. GnRH analogue was co-administered with AI in 37.1 % of cases (n = 39). CR, PR, SD and PD were achieved in 5.7, 23.8, 37.2 and 33.3 % of cases, respectively. The median PFS and OS were equal to 10.0 and 39.0 months, respectively. Co-administration of GnRH analogues was associated with more than threefold increase in rates of clinical benefit (OR = 3.37, 95 % CI 1.30–8.73) but did not seem to correlate with better PFS or OS. No statistically significant associations between the examined outcomes and the other parameters were noted. Available data suggest that AIs may potentially play a promising role in the optimal therapeutic strategy for metastatic male breast cancer patients. Especially, co-administration of AI with a GnRH analogue seems to increase the rate of clinical benefit and could be more effective, warranting further consideration. © 2015, Springer Science+Business Media New York.
ARTIFICIAL NATURES, UNNATURAL DESIRES AND THE UNCONSCIOUS OTHER: THOMAS MORE'S UTOPIA AND PHILIP SIDNEY'S NEW ARCADIA. 1st ed. Saarbrucken, Germany: OmniScriptum, Scholar's Press; 2015 pp. 271.
Chrysostomou S. Assessment in the music classroom: Inherent challenges and the PISA problematic (in Spanish). Revista International de Education Musical. 2015;3:23-30.
Neokosmidis I, Avaritsiotis N, Ventoura Z, Varoutas D. Assessment of the gap and (non-) Internet users evolution based on population biology dynamics. Telecommunications Policy. 2015;39:14–37.
Dautzenberg MJD, Wekesa AN, Gniadkowski M, Antoniadou A, Giamarellou H, Petrikkos GL, Skiada A, Brun-Buisson C, Bonten MJM, Derde LPG. The association between colonization with carbapenemase-producing enterobacteriaceae and overall ICU mortality: an observational cohort study. Crit Care Med. 2015;43(6):1170-7.Abstract
OBJECTIVES: Infections caused by carbapenemase-producing Enterobacteriaceae are increasing worldwide, especially in ICUs, and have been associated with high mortality rates. However, unequivocally demonstrating causality of such infections to death is difficult in critically ill patients because of potential confounding and competing events. Here, we quantified the effects of carbapenemase-producing Enterobacteriaceae carriage on patient outcome in two Greek ICUs with carbapenemase-producing Enterobacteriaceae endemicity. DESIGN: Observational cohort study. SETTING: Two ICUs with carbapenemase-producing Enterobacteriaceae endemicity. PATIENTS: Patients admitted to the ICU with an expected length of ICU stay of at least 3 days were included. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Carbapenemase-producing Enterobacteriaceae colonization was established through screening in perineum swabs obtained at admission and twice weekly and inoculated on chromogenic plates. Detection of carbapenemases was performed phenotypically, with confirmation by polymerase chain reaction. Risk factors for ICU mortality were evaluated using cause-specific hazard ratios and subdistribution hazard ratios, with carbapenemase-producing Enterobacteriaceae colonization as time-varying covariate. One thousand seven patients were included, 36 (3.6%) were colonized at admission, and 96 (9.5%) acquired carbapenemase-producing Enterobacteriaceae colonization during ICU stay, and 301 (29.9%) died in ICU. Of 132 carbapenemase-producing Enterobacteriaceae isolates, 125 (94.7%) were Klebsiella pneumoniae and 74 harbored K. pneumoniae carbapenemase (56.1%), 54 metallo-β-lactamase (40.9%), and four both (3.0%). Carbapenemase-producing Enterobacteriaceae colonization was associated with a statistically significant increase of the subdistribution hazard ratio for ICU mortality (subdistribution hazard ratio=1.79; 95% CI, 1.31-2.43), not explained by an increased daily hazard of dying (cause-specific hazard ratio for death=1.02; 95% CI, 0.74-1.41), but by an increased length of stay (cause-specific hazard ratio for discharge alive=0.73; 95% CI, 0.51-0.94). Other risk factors in the subdistribution hazard model were Acute Physiology and Chronic Health Evaluation II score (subdistribution hazard ratio=1.13; 95% CI, 1.11-1.15), female gender (subdistribution hazard ratio=1.29; 95% CI, 1.02-1.62), presence of solid tumor (subdistribution hazard ratio=1.54; 95% CI, 1.15-2.06), hematopoietic malignancy (subdistribution hazard ratio=1.61; 95% CI, 1.04-2.51), and immunodeficiency (subdistribution hazard ratio=1.59; 95% CI, 1.11-2.27). CONCLUSIONS: Patients colonized with carbapenemase-producing Enterobacteriaceae have on average a 1.79 times higher hazard of dying in ICU than noncolonized patients, primarily because of an increased length of stay.
Nikolaou V, Papadavid E, Ekonomidi A, Dalamaga M, Marinos L, Stratigos A, Papadaki T, Antoniou C. Association of clinicopathological characteristics with secondary neoplastic lymphoproliferative disorders in patients with lymphomatoid papulosis. Leuk Lymphoma. 2015;56(5):1303-7.Abstract
Lymphomatoid papulosis (LyP) refers to an indolent cutaneous lymphoma. The association of prognostic clinicopathological risk factors with a second hematologic malignancy has not yet been determined. We investigated the prognostic effect of clinicopathological characteristics on the occurrence of a second lymphoma, as well as the first-line treatment, in 24 patients diagnosed with LyP using logistic regression models. We showed that lymphoma occurrence was associated with a lower mean age at onset of LyP symptoms, histological types B and C, head-located LyP lesions and a higher frequency of LyP recurrences. In multivariate analyses, histologic type A was associated with a lower risk of second lymphoma (odds ratio [OR] = 0.12, 95% confidence interval [CI] 0.014-0.98; p = 0.045) adjusting for age of LyP first symptomatology, and an important increased lymphoma-free survival rate (long-rank test; p = 0.06). Clinicopathological characteristics are important in defining the clearance or persistence of LyP lesions and may predict the occurrence of a second lymphoma.
Zhang Y, Kollias G, Argyris AA, Papaioannou TG, Tountas C, Konstantonis GD, Achimastos A, Blacher J, Safar ME, Sfikakis PP, et al. Association of left ventricular diastolic dysfunction with 24-h aortic ambulatory blood pressure: The SAFAR study. Journal of Human Hypertension [Internet]. 2015;29(7):442 - 448. Website
Karailias A, Katsiva C, Lagaki V, Kanellakopoulos A, Mertzimekis TJ, Kafantaris F-CA, Godelitsas A. The Athens Mobile γ-Spectrometry System (AMESOS). In: Hellenic Nuclear Physics Society; 2015. Website
Michaelides S, Nastos P, Flocas H. Atmospheric Processes in the Mediterranean. Atmospheric Research [Internet]. 2015;152:1 - 3. Website
Madesis I, Dimitriou A, Laoutaris A, Lagoyannis A, Axiotis M, Mertzimekis T, Andrianis M, Harissopulos S, Benis EP, Sulik B, et al. Atomic Physics with Accelerators: Projectile Electron Spectroscopy (APAPES). In: Journal of Physics: Conference Series. Vol. 583. ; 2015. pp. 012014.Abstract
The new research initiative APAPES (http://apapes.physics.uoc.gr/) has already established a new experimental station with a beam line dedicated for atomic collisions physics research, at the 5 MV TANDEM accelerator of the National Research Centre "Demokritos" in Athens, Greece. A complete zero-degree Auger projectile spectroscopy (ZAPS) apparatus has been put together to perform high resolution studies of electrons emitted in ion-atom collisions. A single stage hemispherical spectrometer with a 2-dimensional Position Sensitive Detector (PSD) combined with a doubly-differentially pumped gas target will be used to perform a systematic isoelectronic investigation of K-Auger spectra emitted from collisions of preexcited and ground state He-like ions with gas targets using novel techniques. Our intention is to provide a more thorough understanding of cascade feeding of the 1s2s2p 4 P metastable states produced by electron capture in collisions of He-like ions with gas targets and further elucidate their role in the non-statistical production of excited three-electron 1s2s2p states by electron capture, recently a field of conflicting interpretations awaiting further resolution. At the moment, the apparatus is being completed and the spectrometer will soon be fully operational. Here we present the project progress and the recent high resolution spectrum obtained in collisions of 12 MeV C 4+ on a Neon gas target.
Korda AI, Asvestas PA, Matsopoulos GK, Ventouras EM, Smyrnis NP. Automatic identification of oculomotor behavior using pattern recognition techniques. Computers in biology and medicine. 2015;60:151–162.
Marsellou EG, Bassiakos YC. Bankrupt Households and Economic Crisis. Evidence from the Greek Courts. Journal of Consumer Policy. 2015:1–22.
Patruno S, Triantaphyllou, M., Erba, E., Dimiza, M., Bottini, C., Kaminski MA. The Barremian and Aptian stepwise development of the "Oceanic Anoxic Event 1a" (OAE 1a) crisis: integrated benthic and planktic high-resolution palaeoecology along the Gorgo a Cebara stratotype section (Umbria-Marche Basin, Italy). Palaeogeography, Palaeoclimatology, Palaeoecology [Internet]. 2015;424:147–182. Publisher's VersionAbstract
The Barremian and Aptianwere times of global plate reconfiguration and profound changes in the ocean–climate system, culminating in the worldwide deposition of lower Aptian black shale layers (OAE 1a). Based on high resolution lithostratigraphic and micropaleontological analyses, precursor conditions and timing of the anoxia are here reconstructed along a 33.06 m thick section in the proposed Barremian/Aptian boundary GSSP stratotype at Gorgo a Cerbara (Umbria–Marche Basin, Italy). A non-uniform history of benthic foraminiferal diversification is interrupted by the Selli Level (= OAE 1a) and by three turnover points for both benthic and planktic organisms, each highlighted by prominent breaks in lithology and outcrop morphology. The first two points, at ~1.1 Myr and ~20–50 kyr prior to the onset of the OAE 1a, correspond respectively to the nannoconid (=bathypelagic calcareous nannofossils) ‘decline’ and ‘crisis’ events, and separate: (a) pelagic limestone/chert-claystone lithological cycles of the uppermost Maiolica Formation, showing frequencies reminiscent of orbital eccentricity and containing an oligotrophic Barremian benthic and planktic assemblage, dominated by k-selected nannoconids and Rhizammina; (b) greenish-grey cherty marls of the lowermost Marne a Fucoidi Formation, associated to declining sedimentation rates and eutrophic early Aptian assemblages dominated by radiolarians and lituolid benthic foraminifera; and (c) anoxic radiolarites and shales of the carbonate-free Selli Level. High magnitude and frequency assemblage fluctuations occur between the nannoconid crisis (~25 cm below the lowermost OAE 1a black shale layer) and the Selli Level base, with suggestions of bottom-water acidification. At ~800 kyr after the OAE 1a end, a third turnover point in the basal reddish member of the Marne a Fucoidi highlights ‘middle’ Aptian assemblages characterized by a bloom of early macroperforate planktic foraminifera (Hedbergella spp.) and appearances of new benthic species, marking a shift towards better oxygenation. OAE 1a oxygen and pelagic carbonate factory crises are here suggested to have been step-wise and linked to global warming conditions.
Nikolopoulos GK, Sypsa V, Bonovas S, Paraskevis D, Malliori-Minerva M, Hatzakis A, Friedman SR. Big Events in Greece and HIV Infection Among People Who Inject Drugs. Subst Use Misuse. 2015;50(7):825-38.Abstract
Big Events are processes like macroeconomic transitions that have lowered social well-being in various settings in the past. Greece has been hit by the global crisis and experienced an HIV outbreak among people who inject drugs. Since the crisis began (2008), Greece has seen population displacement, inter-communal violence, cuts in governmental expenditures, and social movements. These may have affected normative regulation, networks, and behaviors. However, most pathways to risk remain unknown or unmeasured. We use what is known and unknown about the Greek HIV outbreak to suggest modifications in Big Events models and the need for additional research.
Antonarakou, A., Kontakiotis, G., Mortyn, P.G., Drinia, H., Sprovieri, M., Besiou, E., Tripsanas E. Biotic and geochemical (δ18Ο, δ13C, Mg/Ca, Ba/Ca) responses of Globigerinoides ruber morphotypes to upper water column variations during the last deglaciation, Gulf of Mexico. Geochimica et Cosmochimica Acta [Internet]. 2015;170:69-93. Publisher's Version
Karamanou M, Papaioannou TG, Tsoucalas G, Tousoulis D, Stefanadis C, Androutsos G. Blood Pressure Measurement: Lessons Learned from Our Ancestors. Current Pharmaceutical Design [Internet]. 2015;21(6):700 - 704. Website
Cain LE, Phillips A, Olson A, Sabin C, Jose S, Justice A, Tate J, Logan R, Robins JM, Sterne JAC, et al. Boosted lopinavir- versus boosted atazanavir-containing regimens and immunologic, virologic, and clinical outcomes: a prospective study of HIV-infected individuals in high-income countries. Clin Infect Dis. 2015;60(8):1262-8.Abstract
BACKGROUND: Current clinical guidelines consider regimens consisting of either ritonavir-boosted atazanavir or ritonavir-boosted lopinavir and a nucleoside reverse transcriptase inhibitor (NRTI) backbone among their recommended and alternative first-line antiretroviral regimens. However, these guidelines are based on limited evidence from randomized clinical trials and clinical experience. METHODS: We compared these regimens with respect to clinical, immunologic, and virologic outcomes using data from prospective studies of human immunodeficiency virus (HIV)-infected individuals in Europe and the United States in the HIV-CAUSAL Collaboration, 2004-2013. Antiretroviral therapy-naive and AIDS-free individuals were followed from the time they started a lopinavir or an atazanavir regimen. We estimated the 'intention-to-treat' effect for atazanavir vs lopinavir regimens on each of the outcomes. RESULTS: A total of 6668 individuals started a lopinavir regimen (213 deaths, 457 AIDS-defining illnesses or deaths), and 4301 individuals started an atazanavir regimen (83 deaths, 157 AIDS-defining illnesses or deaths). The adjusted intention-to-treat hazard ratios for atazanavir vs lopinavir regimens were 0.70 (95% confidence interval [CI], .53-.91) for death, 0.67 (95% CI, .55-.82) for AIDS-defining illness or death, and 0.91 (95% CI, .84-.99) for virologic failure at 12 months. The mean 12-month increase in CD4 count was 8.15 (95% CI, -.13 to 16.43) cells/µL higher in the atazanavir group. Estimates differed by NRTI backbone. CONCLUSIONS: Our estimates are consistent with a lower mortality, a lower incidence of AIDS-defining illness, a greater 12-month increase in CD4 cell count, and a smaller risk of virologic failure at 12 months for atazanavir compared with lopinavir regimens.
Papaioannou TG, Vavuranakis M, Tousoulis D. Brachial Systolic Blood Pressure Fails to Predict Short-Term Outcome in Patients With Acute Ischemic Stroke: What About Central Systolic Pressure?. American Journal of Hypertension [Internet]. 2015;28(9):1180. Website
Papaioannou TG, Vavuranakis M, Tousoulis D. Brachial Systolic Blood Pressure Fails to Predict Short-Term Outcome in Patients With Acute Ischemic Stroke: What About Central Systolic Pressure?. American journal of hypertension [Internet]. 2015;28(9):1180. Website
Kollatos N, Manta S, Dimopoulou A, Parmenopoulou V, Triantakonstanti VV, Kellici T, Mavromoustakos T, Schols D, Komiotis D. Branched-chain sugar nucleosides: Stereocontrolled synthesis and bioevaluation of novel 3′-C-trifluoromethyl and 3′-C-methyl pyranonucleosides. Carbohydrate Research [Internet]. 2015;407:170 - 178. Website
Vavouranakis G, Bourbou C. Breaking up the past: patterns of fragmentation in Early and Middle Bronze Age tholos tomb contexts in Crete. In: Harrell K, Driessen J THRAVSMA. Contextualising the intentional destruction of objects in the Bronze Age Aegean and Cyprus (Aegis 9). Louvain-la-Neuve: Presses universitaires de Louvain; 2015. pp. 167-196.
Metaxas EI, Balis E, Papaparaskevas J, Spanakis N, Tatsis G, Tsakris A. Bronchiectasis exacerbations: The role of atypical bacteria, respiratory syncytial virus and pulmonary function tests. Can Respir J. 2015;22(3):163-6.Abstract
BACKGROUND: Aside from the known role of common bacteria, there is a paucity of data regarding the possible role of atypical bacteria and viruses in exacerbations of non-cystic fibrosis bronchiectasis. OBJECTIVE: To explore the possible role of atypical bacteria (namely, Mycoplasma pneumoniae and Chlamydophila pneumoniae) and respiratory syncytial virus (RSV) as causative agents of bronchiectasis exacerbations. METHODS: A cohort of 33 patients was studied over a two-year period (one year follow-up for each patient). Polymerase chain reaction for the detection of M pneumoniae, C pneumoniae and RSV in bronchoalveolar lavage samples were performed during all visits. Antibody titres (immunoglobulin [Ig]M and IgG) against the aforementioned pathogens were also measured. In addition, cultures for common bacteria and mycobacteria were performed from the bronchoalveolar lavage samples. RESULTS: Fifteen patients experienced a total of 19 exacerbations during the study period. Although RSV was detected by polymerase chain reaction during stable visits in four patients, it was never detected during an exacerbation. M pneumoniae and C pneumoniae were never detected at stable visits or during exacerbations. IgM antibody titres for these three pathogens were negative in all patient visits. CONCLUSIONS: Atypical pathogens and RSV did not appear to be causative agents of bronchiectasis exacerbations.
Alexandrou A, Armeni E, Kaparos G, Rizos D, Tsoka E, Deligeoroglou E, Creatsa M, Augoulea A, Diamantis T, Lambrinoudaki I. Bsm1 vitamin D receptor polymorphism and calcium homeostasis following bariatric surgery. Journal of Investigative Surgery. 2015;28(1):8 - 17.Abstract
Copyright © 2015 Informa Healthcare USA, Inc. Purpose/Aim: To evaluate the association between the Bsm1 vitamin D receptor polymorphism and the calcium-vitamin D-parathormone axis following bariatric surgery. Materials and Methods: This cross-sectional study included 86 morbidly obese patients, who underwent either gastric bypass or sleeve gastrectomy, with a mean follow-up of four years. Calcium metabolism indices and bone turnover markers were assessed according to the presence of secondary hyperparathyroidism and the Bsm1 vitamin D receptor genotypes. Results: Secondary hyperparathyroidism (42.2% of sample) was associated with lower levels of 25hydroxyvitamin D and elevated markers of bone turnover. In subjects without secondary hyperparathyroidism, presence of the unfavorable B allele resulted in higher levels of parathormone (Bb and BB vs. bb genotype: 50.3 ± 8.2 pg/dl vs. 44.4 ± 10.7 pg/dl, p = .011, adjusted for weight loss, baseline body mass index, 25hydroxyvitamin D, surgical procedure, and duration after surgery). In the whole sample, patients bearing the unfavorable B allele exhibited lower weight loss, a parameter that was negatively associated with markers of bone resorption. Conclusions: Secondary hyperparathyroidism is highly prevalent after bariatric surgery. Bsm1 vitamin D receptor polymorphism may have an effect in early stages of calcium metabolism imbalance, while no association is detected in patients who have already developed secondary hyperparathyroidism. Moreover, vitamin D receptor polymorphism is associated with post-surgery weight loss, a process related to bone turnover.
Dimopoulos MA, Sonneveld P, Siegel D, Palumbo A, San-Miguel J. Carfilzomib and pomalidomide in patients with relapsed and/or refractory multiple myeloma with baseline risk factors. Annals of Oncology [Internet]. 2015;26(11):2247 - 2256. WebsiteAbstract
While survival times have increased over the last decade, most patients with multiple myeloma (MM) eventually relapse and become refractory to therapy. The treatment of patients with relapsed and/or refractory MM is frequently further complicated by the presence of pre-existing comorbidities that arise from an advanced disease state and of toxicities stemming from prior antimyeloma treatment. Carfilzomib and pomalidomide have recently been approved for the treatment of patients with relapsed and refractory MM. While these agents represent important additions to the available treatment options, the identification of patients who may best benefit from the use of each of therapy is still being investigated. A number of patient-related and disease-related factors may impact treatment efficacy and/or tolerability, and the clinical presentation and medical history of each patient must be carefully considered to optimize treatment. Here, we review results from carfilzomib and pomalidomide clinical trials in patients with relapsed and/or refractory MM who also have baseline comorbidities or treatment-induced or disease-induced complications (including the presence of renal impairment, cardiac risk factors, peripheral neuropathy, or high-risk chromosomal abnormalities) to evaluate the safety and efficacy of the two agents in these difficult-to-treat patients and to provide treatment recommendations specific to each scenario. © The Author 2015. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved.
Stewart AK, Rajkumar SV, Dimopoulos MA, Masszi T, Špicka I, Oriol A, Hajek R, Rosinol L, Siegel DS, Mihaylov GG, et al. Carfilzomib, lenalidomide, and dexamethasone for relapsed multiple myeloma. New England Journal of Medicine [Internet]. 2015;372(2):142 - 152. WebsiteAbstract
Background Lenalidomide plus dexamethasone is a reference treatment for relapsed multiple myeloma. The combination of the proteasome inhibitor carfilzomib with lenalidomide and dexamethasone has shown efficacy in a phase 1 and 2 study in relapsed multiple myeloma. Methods We randomly assigned 792 patients with relapsed multiple myeloma to carfilzomib with lenalidomide and dexamethasone (carfilzomib group) or lenalidomide and dexamethasone alone (control group). The primary end point was progression-free survival. Results Progression-free survival was significantly improved with carfilzomib (median, 26.3 months, vs. 17.6 months in the control group; hazard ratio for progression or death, 0.69; 95% confidence interval [CI], 0.57 to 0.83; P = 0.0001). The median overall survival was not reached in either group at the interim analysis. The Kaplan-Meier 24-month overall survival rates were 73.3% and 65.0% in the carfilzomib and control groups, respectively (hazard ratio for death, 0.79; 95% CI, 0.63 to 0.99; P = 0.04). The rates of overall response (partial response or better) were 87.1% and 66.7% in the carfilzomib and control groups, respectively (P<0.001; 31.8% and 9.3% of patients in the respective groups had a complete response or better; 14.1% and 4.3% had a stringent complete response). Adverse events of grade 3 or higher were reported in 83.7% and 80.7% of patients in the carfilzomib and control groups, respectively; 15.3% and 17.7% of patients discontinued treatment owing to adverse events. Patients in the carfilzomib group reported superior health-related quality of life. Conclusions In patients with relapsed multiple myeloma, the addition of carfilzomib to lenalidomide and dexamethasone resulted in significantly improved progression-free survival at the interim analysis and had a favorable risk-benefit profile. (Funded by Onyx Pharmaceuticals; ClinicalTrials.gov number, NCT01080391.) Copyright © 2015 Massachusetts Medical Society. All rights reserved.
Dalla V, Bassiakos Y, Meintanis SG. Characteristic Function‐based Inference for GARCH Models with Heavy‐tailed Innovations. Communications in Statistics - Simulation and Computation [Internet]. 2015:0-0. Publisher's VersionAbstract
We consider estimation and goodness–of–fit tests in GARCH models with innovations following a heavy–tailed and possibly asymmetric distribution. Although the method is fairly general and applies to GARCH models with arbitrary innovation distribution, we consider as special instances the stable Paretian, the variance gamma and the normal inverse Gaussian distribution. Exploiting the simple structure of the characteristic function of these distributions we propose minimum distance estimation based on the empirical characteristic function of properly standardized GARCH–residuals. The finite–sample results presented facilitate comparison with existing methods, while the new procedures are also applied to real data from the financial market.
Papageorgiou F, Godelitsas A, Xanthos S, Voulgaris N, Nastos P, Mertzimekis TJ, Argyraki A, Katsantonis G. Characterization of phosphogypsum deposited in Schistos remediated waste site (Piraeus, Greece). In: Merkel BJ, Arab A Uranium - Past and Future Challenges. Springer International Publishing; 2015. pp. 271-280.Abstract
Abstract The operation of a phosphate fertilizer industry in Drapetsona, near Piraeus port (Greece), resulted in the deposition of 10 million tons of phosphogypsum (PG) into an old limestone quarry, in the period 1979-1989. The whole deposit has been recently remediated using geomembranes and thick soil cover with vegetation. The purpose of the present study was to characterize representative samples of that phosphogypsum, using diffraction (powder-XRD), microscopic (SEM-EDS), analytical (ICP-MS), and spectroscopic techniques (High-resolution γ-ray spectrometry and XRF). The material contains crystalline gypsum (CaSO4.2H2O) and Ca-Si-Al-S-F (chukhrovite-type/meniaylovite) phases. The natural radioactivity is mainly due to the $^{238}$U series and particularly $^{226}$Ra (average: 462 Bq/kg), which is relatively low compared to PG from the rest of the world. Furthermore, leaching experiments using local (Attica) rainwater, together with ICP-MS, were performed to assess the potential release of elements in the environment.
Papageorgiou F, Godelitsas A, Xanthos S, Voulgaris N, Nastos P, Mertzimekis TJ, Argyraki A, Katsantonis G. Characterization of phosphogypsum deposited in Schistos remediated waste site (Piraeus, Greece). In: Uranium-Past and Future Challenges. Springer; 2015. pp. 271–280.
Kritikos N, Vallianatou T, Dotsikas Y, Tsantili-Kakoulidou A. Chemometrics-chem(O)informatics as a tool in quantitative structure – Property and structure – Activity relationships, qspr & qsar. Pharmakeftiki [Internet]. 2015;27:73-100. Website
Lambrinoudaki I, Bouziou G, Armeni E, Spyropoulou A, Koundi K, Rizos D, Augoulea A, Alexandrou A, Creatsa M, Panoulis C, et al. Circulating androgens are associated with mood disturbances in young postmenopausal women. Climacteric. 2015;18(2):205 - 213.Abstract
© 2015 International Menopause Society. Objectives We aimed to evaluate the association between circulating androgens and the presence of psychological symptoms in a sample of healthy middle-aged women. Methods Psychological and depressive symptoms were evaluated in a total of 207 postmenopausal women, using the Symptom Checklist-90-R (SCL-90R) and the Zung Depression Scale, respectively. We investigated the associations between the SCL-90R and Zung Scale scores, and anthropometric, lifestyle parameters, as well as serum levels of androgens. Results The free androgen index was positively associated with scores of depression (b-coefficient ± standard error (SE) = 0.2 ± 0.2, p = 0.040), anxiety (b-coefficient ± SE = 0.2 ± 0.2, p = 0.028), anger/aggressiveness (b-coefficient ± SE = 0.3 ± 0.2, p = 0.026), psychotism (b-coefficient ± SE = 0.3 ± 0.1, p = 0.013) as well as with the global index of the SCL-90R scale (b-coefficient ± SE = 0.2 ± 0.1, p = 0.036), while sex hormone binding globulin was negatively associated with depression (b-coefficient ± SE = -0.2 ± 0.0, p = 0.046) and psychotism (b-coefficient ± SE = -0.2 ± 0.0, p = 0.047). These associations were independent of vasomotor symptomatology, smoking and hormone therapy intake and were more pronounced in younger (≤ 5.5 years) compared to older postmenopausal women. Levels of dehydroepiandrosterone sulfate were positively associated with interpersonal sensitivity (b-coefficient ± SE = 0.3 ± 0.3, p = 0.042), psychotism (b-coefficient ± SE = 0.4 ± 0.2, p = 0.007) and the global index (b-coefficient ± SE = 0.3 ± 0.2, p = 0.040) in women < 5.5 years postmenopausal. No significant associations were observed between the Zung or Greene Scale scores and levels of androgens. Conclusion Higher androgenicity was positively associated with symptoms of anxiety and depression in postmenopausal women. These associations were stronger in women closer to the menopausal transition, a finding which may suggest that menopause rather than aging may mediate the association of androgens with mood disorders.
Philandras CM, Nastos PT, Kapsomenakis IN, Repapis CC. Climatology of upper air temperature in the Eastern Mediterranean region. Atmospheric Research [Internet]. 2015;152:29 - 42. WebsiteAbstract
The goal of this study is to contribute to the climatology of upper air temperature in the Mediterranean region, during the period 1965-2011. For this purpose, both radiosonde recordings and gridded reanalysis datasets of upper air temperature from National Center for Environmental Prediction-National Center for Atmospheric Research (NCEP-NCAR) were used for seven barometric levels at 850. hPa, 700. hPa, 500. hPa, 300. hPa, 200. hPa, 150. hPa and 100. hPa. Trends and variability of upper air temperature were analyzed on annual and seasonal basis. Further, the impact of atmospheric circulation, by means of correlation between upper air temperature at different barometric levels and specific climatic indices such as Mediterranean Oscillation Index (MOI), North Sea Caspian Pattern Index (NCPI) and North Atlantic Oscillation Index (NAOI), was also quantified. Our findings have given evidence that air temperature is increasing at a higher rate in lower/middle troposphere against upper, and this is very likely due to increasing greenhouse gas concentrations. © 2013 Elsevier B.V.
Dimopoulos MA, Terpos E, Niesvizky R, Palumbo A. Clinical characteristics of patients with relapsed multiple myeloma q. Cancer Treatment Reviews [Internet]. 2015;41(10):827 - 835. WebsiteAbstract
Although survival outcomes have improved over the last decade for patients with multiple myeloma (MM), few patients remain free of disease and most inevitably relapse. Selecting a treatment for patients with relapsed MM is challenging given the number and diversity of regimens patients may have previously received, which can affect subsequent therapeutic choices. Importantly, a number of patient- and disease-related factors can also have an effect on treatment choice, treatment efficacy, and tolerability; thus, an understanding of the heterogeneity of patients in the setting of relapsed MM is important for appropriate treatment selection. Here, we review select patient and disease characteristics reported in key interventional and observational studies in relapsed MM (including age, sex, race, and the presence of high-risk disease, renal impairment, or peripheral neuropathy at baseline) to examine common and disparate features of patients with relapsed MM. As therapeutic regimens can have varying efficacy and/or tolerability in patients depending on these factors, we also provide treatment recommendations for patients with select baseline characteristics. © 2015 The Authors.
Loukas YL, Thodi G, Molou E, Georgiou V, Dotsikas Y, Schulpis KH. Clinical diagnostic Next-Generation sequencing: The case of CFTR carrier screening. Scandinavian Journal of Clinical and Laboratory Investigation [Internet]. 2015;75(5):374 - 381. Website
Malinverno E, Triantaphyllou M, Dimiza M. Coccolithophore assemblage distribution along a temperate to polar gradient in the West Pacific sector of the Southern Ocean (January 2005). Micropaleontology [Internet]. 2015;61(6):489-506. Publisher's VersionAbstract
We document surface coccolithophore species composition along a N-S transect from New Zealand to the Ross Sea, across the fronts of the Antarctic Circumpolar Current. Emiliania huxleyi is the most abundant coccolithophore species throughout, with high concentration in the northernmost samples, in the Polar Frontal Zone and at the Polar Front. Three E. huxleyi morphotypes, A, B/C and O were recognized and show different biogeographic distributions along the investigated transect. Coccolithophore distribution appears to be strongly controlled by the location of oceanographic fronts, with minor species (Calcidiscus leptoporus, Syracosphaera spp., Acanthoica quattrospina, Umbellosphaera tenuis, Corisphaera strigilis and other holococcolithophores) largely restricted to the northern Sub-Antarctic Zone, only showing minor occurrence in the southern Sub-Antarctic Zone and being very rare in the Polar Frontal Zone. Our data confirm previous findings and add new information on the biogeography of minor coccolithophore species in relation with oceanographic features. Overall, integration with previous data on the southern extent distribution of E. huxleyi showed no significant temporal shifts in the polar dynamic perspective of the species since early observations.
Triantaphyllou M, Karatsolis B-T, Dimiza M, Malinverno E, Cerino F, Psarra S, Jordan R, Young J. Coccolithophore combination coccospheres from the NE Mediterranean Sea: new evidence and taxonomic revisions. Micropaleontology [Internet]. 2015;61(6):457-472. Publisher's VersionAbstract
Numerous specimens of coccolithophore combination coccospheres in water samples collected from the North Aegean and Tyrrhenian (Mediterranean Sea) have been photographed using the scanning electron microscope.As a consequence a series of taxonomic revisions are proposed, in which the names of the heterococcolithophores and holococcolithophores involved in the same life-cycle are synonymized. This has resulted in synonymizing the genus Coronosphaera with Syracosphaera and establishing one new combination; Syracosphaera arethusae (Kamptner 1941) comb. nov.
Hatzimanolis A, Bhatnagar P, Moes A, Wang R, Roussos P, Bitsios P, Stefanis CN, Pulver AE, Arking DE, Smyrnis N, et al. Common genetic variation and schizophrenia polygenic risk influence neurocognitive performance in young adulthood. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 2015;168:392–401.
Lodi S, Phillips A, Logan R, Olson A, Costagliola D, Abgrall S, van Sighem A, Reiss P, Miró JM, Ferrer E, et al. Comparative effectiveness of immediate antiretroviral therapy versus CD4-based initiation in HIV-positive individuals in high-income countries: observational cohort study. Lancet HIV. 2015;2(8):e335-43.Abstract
BACKGROUND: Recommendations have differed nationally and internationally with respect to the best time to start antiretroviral therapy (ART). We compared effectiveness of three strategies for initiation of ART in high-income countries for HIV-positive individuals who do not have AIDS: immediate initiation, initiation at a CD4 count less than 500 cells per μL, and initiation at a CD4 count less than 350 cells per μL. METHODS: We used data from the HIV-CAUSAL Collaboration of cohort studies in Europe and the USA. We included 55,826 individuals aged 18 years or older who were diagnosed with HIV-1 infection between January, 2000, and September, 2013, had not started ART, did not have AIDS, and had CD4 count and HIV-RNA viral load measurements within 6 months of HIV diagnosis. We estimated relative risks of death and of death or AIDS-defining illness, mean survival time, the proportion of individuals in need of ART, and the proportion of individuals with HIV-RNA viral load less than 50 copies per mL, as would have been recorded under each ART initiation strategy after 7 years of HIV diagnosis. We used the parametric g-formula to adjust for baseline and time-varying confounders. FINDINGS: Median CD4 count at diagnosis of HIV infection was 376 cells per μL (IQR 222-551). Compared with immediate initiation, the estimated relative risk of death was 1·02 (95% CI 1·01-1·02) when ART was started at a CD4 count less than 500 cells per μL, and 1·06 (1·04-1·08) with initiation at a CD4 count less than 350 cells per μL. Corresponding estimates for death or AIDS-defining illness were 1·06 (1·06-1·07) and 1·20 (1·17-1·23), respectively. Compared with immediate initiation, the mean survival time at 7 years with a strategy of initiation at a CD4 count less than 500 cells per μL was 2 days shorter (95% CI 1-2) and at a CD4 count less than 350 cells per μL was 5 days shorter (4-6). 7 years after diagnosis of HIV, 100%, 98·7% (95% CI 98·6-98·7), and 92·6% (92·2-92·9) of individuals would have been in need of ART with immediate initiation, initiation at a CD4 count less than 500 cells per μL, and initiation at a CD4 count less than 350 cells per μL, respectively. Corresponding proportions of individuals with HIV-RNA viral load less than 50 copies per mL at 7 years were 87·3% (87·3-88·6), 87·4% (87·4-88·6), and 83·8% (83·6-84·9). INTERPRETATION: The benefits of immediate initiation of ART, such as prolonged survival and AIDS-free survival and increased virological suppression, were small in this high-income setting with relatively low CD4 count at HIV diagnosis. The estimated beneficial effect on AIDS is less than in recently reported randomised trials. Increasing rates of HIV testing might be as important as a policy of early initiation of ART. FUNDING: National Institutes of Health.
Sadeghpour A, Rappolt M, Ntountaniotis D, Chatzigeorgiou P, Viras K, Megariotis G, Papadopoulos MG, Siapi E, Mali G, Mavromoustakos T. Comparative study of interactions of aliskiren and AT<inf>1</inf> receptor antagonists with lipid bilayers. Biochimica et Biophysica Acta - Biomembranes [Internet]. 2015;1848(4):984 - 994. Website
Kourlaba G, Dimopoulos MA, Pectasides D, Skarlos DV, Gogas H, Pentheroudakis G, Koutras A, Fountzilas G, Maniadakis N. Comparison of filgrastim and pegfilgrastim to prevent neutropenia and maintain dose intensity of adjuvant chemotherapy in patients with breast cancer. Supportive Care in Cancer [Internet]. 2015;23(7):2045 - 2051. WebsiteAbstract
Purpose: The aim of this study was to compare the effectiveness of prophylactic single fixed dose of pegfilgrastim and daily administration of filgrastim on febrile neutropenia (FN), severe neutropenia, treatment delay, and dose reduction in patients with breast cancer receiving dose-dense adjuvant chemotherapy. Methods: A retrospective cohort study with 1058 breast cancer patients matched by age and chemotherapy was conducted. The primary endpoints were FN, severe (grade 3, 4) neutropenia, dose reduction (>10 % reduction of the dose planned), and treatment delay (dose given more than 2 days later). Results: Eighteen episodes of FN (3.4 %) in the filgrastim group and 23 (4.3 %) in the pegfilgrastim group (p = 0.500) were recorded. More than half of the total episodes (27/41) occurred during the first 4 cycles of treatment. Patients who received filgrastim were almost three times more likely to experience a severe neutropenia episode and were significantly more likely to experience a dose reduction (18.5 %) compared to those who received pegfilgrastim (10.8 %) (p < 0.001). The percentage of patients, who received their planned dose on time, was significantly lower in patients receiving filgrastim (58 %) compared to those receiving pegfilgrastim (72.4 %, p < 0.001). Conclusions: No significant difference was detected on FN rate between daily administration of filgrastim and single administration of pegfilgrastim. However, patients receiving pegfilgrastim had a significantly lower rate of severe neutropenia, as well as dose reduction and treatment delay, thus, achieving a higher dose density. © 2014, Springer-Verlag Berlin Heidelberg.
Souglis A a, Bogdanis GC a, Giannopoulou I a, Papadopoulos C b, c Apostolidis N a. Comparison of Inflammatory Responses and Muscle Damage Indices Following a Soccer, Basketball, Volleyball and Handball Game at an Elite Competitive Level. Research in Sports Medicine [Internet]. 2015;23:59-72. WebsiteAbstract
Inflammatory responses and muscle damage indices were compared between four popular team sports at an elite level. Seventy two male elite players of four team sports: soccer (n = 18), basketball (n = 18), volleyball (n = 18) and handball (n = 18), completed an official match, while 18 non-athletes served as controls. Blood samples were drawn before, immediately after and 13 and 37 h post-match. Soccer produced the greatest increase in inflammatory cytokines (tumor necrosis factor-alpha and interleukin-6), which were increased by 3-4 fold immediately after the game, as well as in C-reactive protein, which was increased by threefold in the next morning after the match. Metabolic stress (urea, ammonia and cortisol) and muscle damage indices (creatine kinase and lactate dehydrogenase) were also higher after soccer, with creatine kinase responses being almost 2-3 times higher than the other sports. Volleyball showed the smallest increase in inflammation and muscle damage markers compared with the other three sports. © 2014 © 2014 Taylor & Francis.
Souglis AG a, Papapanagiotou A b, Bogdanis GC a, Travlos AK c, Apostolidis NG a, Geladas ND a. Comparison of inflammatory responses to a soccer match between elite male and female players. Journal of Strength and Conditioning Research [Internet]. 2015;29:1227-1233. WebsiteAbstract
The aim of this study was to compare the inflammatory responses between male and female soccer players for a period of 48 hours after an official match. Blood samples were taken from 83 subjects (22 elite male and 21 elite female soccer players and 20 male and 20 female inactive individuals) in the morning of the game day, immediately after the soccer game and 24 and 48 hours after the match. Average relative exercise intensity during the match was similar in male and female players, as indicated by mean heart rate that was 86.9 ± 4.3 and 85.6 ± 2.3% of maximal heart rate (p 0.23), respectively. Interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) increased 2- to 4-fold above resting values, peaking immediately after the match. C-reactive protein (CRP) and creatine kinase peaked 24 hours after the match. Interleukin 6, CRP, and creatine kinase responses were similar in male and female players, but the peak in TNF-α was 18% higher in male players. Interleukin 6, TNF-α, and CRP at rest were lower in male and female players compared with the control subjects, suggesting a protective effect of regular exercise training regarding the inflammatory profile. The results of this study show that a soccer match induces significant inflammatory responses in both male and female players, with only TNF-α peak values being lower in females. Because of the effects of inflammatory responses on performance and health of the players, it is suggested that coaches and trainers should adjust exercise training programs after a match to promote recovery and protect the athletes' health. © 2015 National Strength and Conditioning Association.
Souglis, A.G.a PBTAGA b GC. Comparison of inflammatory responses to a soccer match between elite male and female players. Journal of Strength and Conditioning Research [Internet]. 2015;29:1227-1233. WebsiteAbstract
The aim of this study was to compare the inflammatory responses between male and female soccer players for a period of 48 hours after an official match. Blood samples were taken from 83 subjects (22 elite male and 21 elite female soccer players and 20 male and 20 female inactive individuals) in the morning of the game day, immediately after the soccer game and 24 and 48 hours after the match. Average relative exercise intensity during the match was similar in male and female players, as indicated by mean heart rate that was 86.9 ± 4.3 and 85.6 ± 2.3% of maximal heart rate (p 0.23), respectively. Interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) increased 2- to 4-fold above resting values, peaking immediately after the match. C-reactive protein (CRP) and creatine kinase peaked 24 hours after the match. Interleukin 6, CRP, and creatine kinase responses were similar in male and female players, but the peak in TNF-α was 18% higher in male players. Interleukin 6, TNF-α, and CRP at rest were lower in male and female players compared with the control subjects, suggesting a protective effect of regular exercise training regarding the inflammatory profile. The results of this study show that a soccer match induces significant inflammatory responses in both male and female players, with only TNF-α peak values being lower in females. Because of the effects of inflammatory responses on performance and health of the players, it is suggested that coaches and trainers should adjust exercise training programs after a match to promote recovery and protect the athletes' health. © 2015 National Strength and Conditioning Association.
Kastritis E, Kyrtsonis M-C, Morel P, Gavriatopoulou M, Hatjiharissi E, Symeonidis AS, Vassou A, Repousis P, Delimpasi S, Sioni A, et al. Competing risk survival analysis in patients with symptomatic waldenström macroglobulinemia: The impact of disease unrelated mortality and of rituximab-based primary therapy. Haematologica [Internet]. 2015;100(11):e448 - e449. Website
Dimiza M, Triantaphyllou M, Malinverno E, Psarra S, Karatsolis B-T, Mara P, Lagaria A, Gogou A. The composition and distribution of living coccolithophores in the Aegean Sea (NE Mediterranean). Micropaleontology [Internet]. 2015;61(6):521-540. Publisher's VersionAbstract
This study presents the species composition of living coccolithophore communities in the Aegean Sea (northeastern Mediterranean), investigating their spatial and temporal variations in various environmental conditions from mesotrophic to ultra- oligotrophic regions. Coccolithophores of the photic zone in the Aegean Sea are relatively diverse (65 heterococcolithophores and 34 holococcolithophores) and dominated mostly by Emiliania huxleyi, Syracosphaera spp., Rhabdosphaeraceae and holococcolithophores. Hierarchical classification using R-mode cluster analysis distinguished five coccolithophore groups: Group Ia (Emiliania huxleyi, Syracosphaera molischii and Syracosphaera ossa) prevails in the high cell density and low diversity assemblages during the winter and early spring, when low temperatures and high nutrient concentrations are prevailing. Particularly in the north Aegean, E. huxleyi is dominating the upper photic zone being affected by the Black Sea Water inflow and the associated control on the water column stratification. Group Ib (Florisphaera profunda, Algirosphaera robusta, Syracosphaera anthos and Syracosphaera lamina) becomes important in the lower photic zone, making up the typical deep assemblages, whereas Group Ic (mainly Helicosphaera carteri and Gephyrocapsa oceanica) implies an opportunistic behavior in distinctly polluted neritic regions. Group IIa (Rhabdosphaera clavigera, Syracosphaera protrudens, Syracosphaera halldalii and numerous holococcolithophores) dominates the late spring-early autumn low cell density and high diversity assemblages, mainly in the thermally-stratified south Aegean and/or shallow, coastal environments with normal/ oligotrophic conditions, while Group IIb (Umbellosphaera tenuis and Syracosphaera pulchra) dominates the coccolithophore assemblages mainly during the early autumn in the north Aegean, thus reflecting the influence of Levantine Intermediate Water masses in the middle-lower photic zone. Our results suggest that abundance and variability in Aegean Sea coccolithophore assemblages are primarily controlled by surface water circulation and the associated water column stratification,with the sea temperature gradient affecting species composition.
Arabatzis T, Nersessian NJ. Concepts Out of Theoretical Contexts. In: T. Arabatzis, J. Renn, A. Simões (eds.), Relocating the History of Science: Essays in Honor of Kostas Gavroglu. Dordrecht: Springer; 2015. pp. 225-238. Publisher's VersionAbstract
In this paper we take as our point of departure Kostas Gavroglu and Yorgos Goudaroulis’s insight that, in the process of describing and explaining novel phenomena, scientific concepts are taken “out of” their original theoretical context, acquire additional meaning, and become relatively autonomous. We first present their account of how concepts are re-contextualized and, in the process, extended and/or revised. We then situate it within its philosophical context, and discuss how it broke with a long-standing philosophical tradition about concepts. Finally, we argue that recent developments in science studies can flesh out and vindicate the “concepts out of contexts” idea. In particular, historical and philosophical studies of experimentation and cognitive-historical studies of modeling practices indicate various ways in which concepts are formed and articulated “out of context”.
Sifianou M. Conceptualizing politeness in Greek: Evidence from Twitter corpora. Journal of Pragmatics. 2015;86:25–30.
Kenourgios, D. DD. Contagion of the Global Financial Crisis and the real economy: A regional analysis. Economic Modelling [Internet]. 2015;44:283-293. Website
Palumbo A, Gay F, Cavallo F, Raimondo FD, Larocca A, Hardan I, Nagler A, Petrucci MT, Hajek R, Pezzatti S, et al. Continuous therapy versus fixed duration of therapy in patients with newly diagnosed multiple myeloma. Journal of Clinical Oncology [Internet]. 2015;33(30):3459 - 3466. WebsiteAbstract
Purpose: Continuous therapy (CT) prolongs progression-free survival 1 (PFS1; time from random assignment until the first progression or death), but chemotherapy-resistant relapse may negatively impact overall survival (OS). Progression-free survival 2 (PFS2; time from random assignment until the second progression or death) may represent an additional tool to estimate outcome. This study evaluates the benefit of novel agent-based CT versus fixed duration of therapy (FDT) in patients with newly diagnosed myeloma. Methods: We included patients enrolled onto three phase III trials that randomly assigned patients to novel agent-based CT versus FDT. Primary analyses were restricted to the intent-to-treat population eligible for CT (patients progression free and alive at 1 year after random assignment). Primary end points were PFS1, PFS2, and OS. All hazard ratios (HRs) and 95% CIs were adjusted for several potential confounders using Cox models. Results: In the pooled analysis of the three trials, 604 patients were randomly assigned to CT and 614 were assigned to FDT. Median follow-up was 52 months. In the intent-to-treat CT population, CT (n = 417), compared with FDT (n = 410), significantly improved PFS1 (median, 32 v 16 months, respectively; HR, 0.47; 95% CI, 0.40 to 0.56; P < .001), PFS2 (median, 55 v 40 months, respectively; HR, 0.61; 95% CI, 0.50 to 0.75; P < .001), and OS (4-year OS, 69% v 60%, respectively; HR, 0.69; 95% CI, 0.54 to 0.88; P = .003). Conclusion: In this pooled analysis, CT significantly improved PFS1, PFS2, and OS. The improvement in PFS2 suggests that the benefit reported during first remission is not cancelled by a shorter second remission. PFS2 is a valuable end point to estimate long-term clinical benefit and should be included in future trials. Copyright © 2015 American Society of Clinical Oncology. All rights reserved.
Patsantaras N. Cosmopolitanism: An alternative way of thinking in the Contemporary Olympics. EJSS. European Journal for Sport and Society. 2015;12:215.
Dimopoulos MA, Richardson PG, Moreau P, Anderson KC. Current treatment landscape for relapsed and/or refractory multiple myeloma. Nature Reviews Clinical Oncology [Internet]. 2015;12(1):42 - 54. WebsiteAbstract
Recent developments in the treatment of multiple myeloma have led to improvements in response rates and to increased survival; however, relapse is inevitable in almost all patients. Recurrence of myeloma is typically more aggressive with each relapse, leading to the development of treatment-refractory disease, which is associated with a shorter survival. Several phase II and III trials have demonstrated the efficacy of recently approved agents in the setting of relapsed and/or refractory multiple myeloma, including immunomodulatory agents, such as lenalidomide and pomalidomide, and proteasome inhibitors, such as bortezomib and carfilzomib. Currently, however, there is no standard treatment for patients with relapsed and/or refractory disease. This Review discusses the current treatment landscape for patients with relapsed and/or refractory multiple myeloma and highlights disease-related and patient-related factors - such as pre-existing comorbidities or toxicities - that are important considerations for clinicians when selecting an appropriate treatment regimen.
Dimopoulos MA, Weise KC, Song KW, Delforge M, Karlin L, Goldschmidt H, Moreau P, Banos A, Oriol A, Garderet L, et al. Cytogenetics and long-term survival of patients with refractory or relapsed and refractory multiple myeloma treated with pomalidomide and low-dose dexamethasone. Haematologica [Internet]. 2015;100(10):1327 - 1333. WebsiteAbstract
Patients with refractory or relapsed and refractory multiple myeloma who no longer receive benefit from novel agents have limited treatment options and short expected survival. del(17p) and t(4;14) are correlated with shortened survival. The phase 3 MM-003 trial demonstrated significant progression-free and overall survival benefits from treatment with pomalidomide plus low-dose dexamethasone compared to high-dose dexamethasone among patients in whom bortezomib and lenalidomide treatment had failed. At an updated median follow-up of 15.4 months, the progression-free survival was 4.0 versus 1.9 months (HR, 0.50; P<0.001), and median overall survival was 13.1 versus 8.1 months (HR, 0.72; P=0.009). Pomalidomide plus low-dose dexamethasone, compared with highdose dexamethasone, improved progression-free survival in patients with del(17p) (4.6 versus 1.1 months; HR, 0.34; P <0.001), t(4;14) (2.8 versus 1.9 months; HR, 0.49; P=0.028), and in standard-risk patients (4.2 versus 2.3 months; HR, 0.55; P<0.001). Although the majority of patients treated with high-dose dexamethasone took pomalidomide after discontinuation, the overall survival of patients treated with pomalidomide plus low-dose dexamethasone or highdose dexamethasone was 12.6 versus 7.7 months (HR, 0.45; P=0.008) in patients with del(17p), 7.5 versus 4.9 months (HR, 1.12; P=0.761) in those with t(4;14), and 14.0 versus 9.0 months (HR, 0.85; P=0.380) in standard-risk subjects. The overall response rate was higher in patients treated with pomalidomide plus low-dose dexamethasone than in those treated with high-dose dexamethasone both among standard-risk patients (35.2% versus 9.7%) and those with del(17p) (31.8% versus 4.3%), whereas it was similar in patients with t(4;14) (15.9% versus 13.3%). The safety of pomalidomide plus low-dose dexamethasone was consistent with initial reports. In conclusion, pomalidomide plus low-dose dexamethasone is efficacious in patients with relapsed/refractory multiple myeloma and del(17p) and/or t(4;14). This study is registered at ClinicalTrials.gov as NCT01311687 and with EudraCT as 2010-019820-30. © 2015 Ferrata Storti Foundation.
Paraskevis D, Angelis K, Magiorkinis G, Kostaki E, Ho SYW, Hatzakis A. Dating the origin of hepatitis B virus reveals higher substitution rate and adaptation on the branch leading to F/H genotypes. Mol Phylogenet Evol. 2015;93:44-54.Abstract
The evolution of hepatitis B virus (HBV), particularly its origins and evolutionary timescale, has been the subject of debate. Three major scenarios have been proposed, variously placing the origin of HBV in humans and great apes from some million years to only a few thousand years ago (ka). To compare these scenarios, we analyzed 105 full-length HBV genome sequences from all major genotypes sampled globally. We found a high correlation between the demographic histories of HBV and humans, as well as coincidence in the times of origin of specific subgenotypes with human migrations giving rise to their host indigenous populations. Together with phylogenetic evidence, this suggests that HBV has co-expanded with modern humans. Based on the co-expansion, we conducted a Bayesian dating analysis to estimate a precise evolutionary timescale for HBV. Five calibrations were used at the origins of F/H genotypes, D4, C3 and B6 from respective indigenous populations in the Pacific and Arctic and A5 from Haiti. The estimated time for the origin of HBV was 34.1ka (95% highest posterior density interval 27.6-41.3ka), coinciding with the dispersal of modern non-African humans. Our study, the first to use full-length HBV sequences, places a precise timescale on the HBV epidemic and also shows that the "branching paradox" of the more divergent genotypes F/H from Amerindians is due to an accelerated substitution rate, probably driven by positive selection. This may explain previously observed differences in the natural history of HBV between genotypes F1 and A2, B1, and D.
Balios D, Eriotis N, Missiakoulis S, Vasiliou D. Delisted versus voluntary delisted versus remain listed: an ordered analysis. Applied Economics Letters. 2015;22(1):66-70.Abstract
Public companies were classified according to whether they remain public or they have been delisted voluntarily or not. Proxy variables were separated according to accounting and/or market information and an ordered polytomous logit model was then applied in order to estimate the probability of delisting. Companies with poor liquidity, high leverage, big stock price decline and lack of interest from investors’ point of view (low trading activity) have higher probability to be delisted, voluntarily or not.
Hatzakis A, Sypsa V, Paraskevis D, Nikolopoulos G, Tsiara C, Micha K, Panopoulos A, Malliori M, Psichogiou M, Pharris A, et al. Design and baseline findings of a large-scale rapid response to an HIV outbreak in people who inject drugs in Athens, Greece: the ARISTOTLE programme. Addiction. 2015;110(9):1453-67.Abstract
AIMS: To (i) describe an intervention implemented in response to the HIV-1 outbreak among people who inject drugs (PWIDs) in Greece (ARISTOTLE programme), (ii) assess its success in identifying and testing this population and (iii) describe socio-demographic characteristics, risk behaviours and access to treatment/prevention, estimate HIV prevalence and identify risk factors, as assessed at the first participation of PWIDs. DESIGN: A 'seek, test, treat, retain' intervention employing five rounds of respondent-driven sampling. SETTING: Athens, Greece (2012-13). PARTICIPANTS: A total of 3320 individuals who had injected drugs in the past 12 months. INTERVENTION: ARISTOTLE is an intervention that involves reaching out to high-risk, hard-to-reach PWIDs ('seek'), engaging them in HIV testing and providing information and materials to prevent HIV ('test') and initiating and maintaining anti-retroviral and opioid substitution treatment for those testing positive ('treat' and 'retain'). MEASUREMENTS: Blood samples were collected for HIV testing and personal interviews were conducted. FINDINGS: ARISTOTLE recruited 3320 PWIDs during the course of 13.5 months. More than half (54%) participated in multiple rounds, resulting in 7113 visits. HIV prevalence was 15.1%. At their first contact with the programme, 12.5% were on opioid substitution treatment programmes and the median number of free syringes they had received in the preceding month was 0. In the multivariable analysis, apart from injection-related variables, homelessness was a risk factor for HIV infection in male PWIDs [odds ratio (OR) yes versus no = 1.89, 95% confidence interval (CI) = 1.41, 2.52] while, in female PWIDS, the number of sexual partners (OR for > 5 versus one partner in the past year = 4.12, 95% CI = 1.93, 8.77) and history of imprisonment (OR yes versus no = 2.76, 95% CI = 1.43, 5.31) were associated with HIV. CONCLUSIONS: In Athens, Greece, the ARISTOTLE intervention for identifying HIV-positive people among people who inject drugs (PWID) facilitated rapid identification of a hidden population experiencing an outbreak and provided HIV testing, counselling and linkage to care. According to ARISTOTLE data, the 2011 HIV outbreak in Athens resulted in 15% HIV infection among PWID. Risk factors for HIV among PWID included homelessness in men and history of imprisonment and number of sexual partners in women.
Paramithiotis, S. ASDPAKE. Detection of DNA sequences originating from GMOs in milk and dairy products commercially available in Greece. Agro Food Industry Hi-Tech [Internet]. 2015;26:52-56. Website
Alexandrou A, Tsoka E, Armeni E, Rizos D, Diamantis T, Augoulea A, Panoulis C, Liakakos T, Lambrinoudaki I. Determinants of secondary hyperparathyroidism in bariatric patients after roux-en-y gastric bypass or sleeve gastrectomy: A pilot study. International Journal of Endocrinology. 2015;2015.Abstract
© 2015 Andreas Alexandrou et al. Objective. Nutritional deficiencies are common after bariatric surgery. We aimed to assess the prevalence and possible predictors of secondary hyperparathyroidism (SHPT) in bariatric patients. Methods. A total of 95 patients who had undergone Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG) were assessed after a median of 3 years after surgery. Anthropometric/demographic and weight-loss parameters were compared according to the presence of SHPT, independently for men/premenopausal women and postmenopausal women. Results. SHPT was highly prevalent (men/premenopausal women, 52.1%; postmenopausal women, 31.9%). Among men/premenopausal women, multivariate analysis indicated that SHPT was predicted by (a) 25-hydroxyvitamin D levels (Exp(B) = 0.869, P-value = 0.037), independently of age, sex, smoking; (b) calcium (Exp(B) = 0.159, P-value = 0.033) and smoking, independently of age and sex; (c) magnesium (Exp(B) = 0.026, P-value = 0.046) and smoking, independently of age and sex. Among postmenopausal women, SHPT was predicted by menopausal age independently of age, smoking, and levels of 25-hydroxyvitamin D or calcium. The development of SHPT was not associated with the type of surgery. Conclusions. RYGB and SG exhibited similar effects regarding the regulation of the hypothalamus-pituitary-parathyroid axis after surgery. Vitamin D status and menopausal age appear to determine SHPT on the long term. SHPT should be sought and vigorously treated with calcium and vitamin D supplementation.
Kastritis E, Gavriatopoulou M, Kyrtsonis M-C, Roussou M, Hadjiharissi E, Symeonidis A, Repoussis P, Michalis E, Delimpasi S, Tsatalas K, et al. Dexamethasone, rituximab, and cyclophosphamide as primary treatment of Waldenström macroglobulinemia: Final analysis of a phase 2 study. Blood [Internet]. 2015;126(11):1392 - 1394. Website
Digital textbooks and the politics of content enrichment in EFL textbooks
Mitsikopoulou B. Digital textbooks and the politics of content enrichment in EFL textbooks. In: Curdt-Christiansen XL, Weninger C Language, Ideology and Education: The Politics of Textbooks in Language Education. London: Routledge; 2015. pp. 404-430. Publisher's Version digital_textbooks_politics_of_enrichment.pdf
Zagouri F, Liakou P, Bartsch R, Peccatori FA, Tsigginou A, Dimitrakakis C, Zografos GC, Dimopoulos M-A, Azim HA. Discrepancies between ESMO and NCCN breast cancer guidelines: An appraisal. Breast [Internet]. 2015;24(4):513 - 523. WebsiteAbstract
An ever growing number of medical organizations, societies, working groups and governmental agencies issue algorithms i.e. guidelines, of decision making flowcharts in diagnosis and treatment in a variety of diseases. In the field of evidence-based diagnosis and treatment of breast cancer, a large number of guidelines are available both from medical associations and national health departments. Among the most appreciated and utilized comprehensive guides is the European Society for Medical Oncology (ESMO) Breast Cancer Guidelines and from the other side of the Atlantic the National Comprehensive Cancer Network (NCCN) Guidelines in Breast Cancer. Although there is much concordance between the guidelines from these two organizations, it is intriguing to locate their discrepancies also. The aim of this report is to present a number of different points between ESMO and NCCN in the whole spectrum of breast cancer management, from prevention and diagnosis to treatment and follow up. This systematic review was performed in accordance with the PRISMA guidelines using a predefined search strategy and summarizes in detail, the differences between ESMO and NCCN guidelines regarding genetic risk evaluation and screening, surgery, chemotherapy, endocrine treatment, targeted biological agents, radiotherapy, pregnancy and fertility and follow-up. © 2015 Elsevier Ltd.
The discursive construction of the recent European economic crisis in two political magazines
Mitsikopoulou B, Lykou C. The discursive construction of the recent European economic crisis in two political magazines. On the Horizon [Internet]. 2015;23(3):190-201. Publisher's Version mitsikopoulou_lykou_2015_on_the_horizon.pdf
Botsou F, Godelitsas A, Kaberi H, Mertzimekis TJ, Goettlicher J, Steininger R, Scoullos M. Distribution and partitioning of major and trace elements in pyrite-bearing sediments of a Mediterranean coastal lagoon. Chemie der Erde. 2015;75:–.Abstract
Abstract The formation of iron sulphide minerals exerts significant control on the behaviour of trace elements in sediments. In this study, three short sediment cores, retrieved from the remote Antinioti lagoon (N. Kerkyra Island, \{NW\} Greece), are investigated concerning the solid phase composition, distribution, and partitioning of major (Al, Fe) and trace elements (Cd, Cu, Mn, Pb, and Zn). According to $^{210}$Pb, the sediments sampled correspond to depositions of the last 120 years. The high amounts of organic carbon (4.1–27.5%) result in the formation of Fe sulphides, predominantly pyrite, already at the surface sediment layers. Pyrite morphologies include monocrystals, polyframboids, and complex FeS–FeS$_2$ aggregates. According to synchrotron-generated micro X-ray fluorescence and X-ray absorption near-edge structure spectra, authigenically formed, Mn-containing, Fe(III) oxyhydroxides (goethite type) co-exist with pyrite in the sediments studied. Microscopic techniques evidence the formation of galena, sphalerite and CuS, whereas sequential extractions show that carbonates are important hosts for Mn, Cd, and Zn. However, significant percentages of non-lattice held elements are bound to Fe/Mn oxyhydroxides that resist reductive dissolution (on average 60% of Pb, 46% of Cd, 43% of Zn and 9% of Cu). The partitioning pattern changes drastically in the deeper part of the core that is influenced by freshwater inputs. In these sediments, the post-depositional pyritization mechanism, illustrated by overgrowths of Fe monosulphides on pre-existing pyrite grains, results in relatively high degree of pyritization that reaches 49% for Cd, 66% for Cu, 32% for Zn and 7% for Pb.
I Z. . Journal of Aquaculture Research and Development [Internet]. 2015;6(5):332. j_aquac_res_development.pdf
Kenourgios D, Papadamou S, Dimitriou D. . Finance Research Letters [Internet]. 2015;14:128-134.
This paper examines the effects of quantitative easing (QE) announcements by the European Central Bank (ECB), the Bank of England (BoE) and the Bank of Japan (BoJ) on the intraday volatility transmissions among EUR, GBP and JPY. The empirical results indicate: (i) an increased volatility transmission from EUR to JPY and GBP around the ECB announcements, and from GBP to EUR over the BoE announcements, (ii) the ECB and BoE announcements significantly increase the volatility of EUR and JPY, and (iii) a ‘‘calming down’’ impact on the volatility of EUR and GBP from the BoJ and the ECB announcements, respectively.
Bakogeorgos M, Mountzios G, Bournakis E, Economopoulou P, Kotsantis G, Fytrakis N, Kouvatseas G, Dimopoulos M-A, Kentepozidis N. Do elderly patients with non-small cell lung cancer get the best out of recent advances in first-line treatment? A comparative study in two tertiary cancer centers in Greece. Journal of Geriatric Oncology [Internet]. 2015;6(2):111 - 118. WebsiteAbstract
Background: Elderly patients with advanced non-small cell lung cancer (NSCLC) are thought to receive suboptimal treatment mainly due to concerns for poor compliance and/or excessive toxicity. Patients and Methods: Using the age of 70. years as the pre-defined cut-off, we compared elderly patients with advanced NSCLC suitable for first line chemotherapy with their younger counterparts in terms of: i) diagnosis and disease characteristics ii) adherence to treatment schedule, including dose intensity (DI), and relative dose intensity (RDI), iii) toxicity, tolerance, and efficacy outcomes. Results: Among 292 eligible patients, data were available for 245, of whom 107 (43.7%) belonged to the elderly group. This group was more likely to present with co-morbidities, non-smoking current status and diagnosis based on cytology alone. As compared to the non-elderly, elderly patients were more likely to receive single-agent therapy (8.0% vs. 29.2% respectively, p<. 0.001) and less likely to receive platinum-based chemotherapy (80.3% vs. 57.9%, p<. 0.001). Elderly patients also received docetaxel (24.3% vs. 40.4%), and bevacizumab (7.5% vs. 21.3%) significantly less often and received oral vinorelbine (24.3% vs. 11.8%) more frequently. Non-elderly patients were more likely to receive any of the cytotoxic drugs with RDI. >. 0.8 (49.6% vs. 33.0%, p=. 0.012) and RDI. >. 0.9 (29.6% vs. 16%, p=. 0.015). Substantial toxicity, as well as median overall survival did not differ significantly between the two groups. Conclusions: Only one third of the elderly patients received at least 80% of the scheduled treatment intensity. Nearly half received diagnosis based on cytology alone, which may deprive them from new, histology-driven, therapeutic approaches. © 2014 Elsevier Inc.
Nastos PT, Kapsomenakis J, Dalezios NR, Kotsopoulos S, Poulos S. Drought variability over Thessaly plain, Greece. Present and future changes. 2015.
Kouroutzoglou J, Flocas HA, Hatzaki M, Keay K, Simmonds I, Mavroudis A. On the dynamics of a case study of explosive cyclogenesis in the Mediterranean. Meteorology and Atmospheric Physics [Internet]. 2015;127(1):49 - 73. Publisher's Version
Felekouras E, Petrou A, Neofytou K, Moris D, Dimitrokalis N, Bramis K, Griniatsos J, Pikoulis E, Diamantis T. Early or Delayed Intervention for Bile Duct Injuries following Laparoscopic Cholecystectomy? A Dilemma Looking for an Answer. Gastroenterol Res Pract [Internet]. 2015;(Article ID 104235). Publisher's VersionAbstract
Background. To evaluate the effect of timing of management and intervention on outcomes of bile duct injury. Materials and Methods. We retrospectively analyzed 92 patients between 1991 and 2011. Data concerned patient’s demographic characteristics, type of injury (according to Strasberg classification), time to referral, diagnostic procedures, timing of surgical management, and final outcome. The endpoint was the comparison of postoperative morbidity (stricture, recurrent cholangitis, required interventions/dilations, and redo reconstruction) and mortality between early (less than 2 weeks) and late (over 12 weeks) surgical reconstruction. Results. Three patients were treated conservatively, two patients were treated with percutaneous drainage, and 13 patients underwent PTC or ERCP. In total 74 patients were operated on in our unit. 58 of them underwent surgical reconstruction by end-to-side Roux-en-Y hepaticojejunostomy, 11 underwent primary bile duct repair, and the remaining 5 underwent more complex procedures. Of the 56 patients, 34 patients were submitted to early reconstruction, while 22 patients were submitted to late reconstruction. After a median follow-up of 93 months, there were two deaths associated with BDI after LC. Outcomes after early repairs were equal to outcomes after late repairs when performed by specialists. Conclusions. Early repair after BDI results in equal outcomes compared with late repair. BDI patients should be referred to centers of expertise and experience.
Molou E, Schulpis KH, Birbilis C, Thodi G, Georgiou V, Dotsikas Y, Loukas YL. Early screening of FTO and MC4R variants in newborns of Greek origin. Journal of Pediatric Endocrinology and Metabolism [Internet]. 2015;28(5-6):619 - 622. Website
Liapis K, Kastritis E, Bagratouni T, Vassiliou S, Papachristidis A, Charitaki E, Alevizopoulos N, Harhalakis N, Terpos E, Delimpasi S, et al. Early tumor-cell gene expression changes may predict the response to first-line bortezomib-based therapy in patients with newly diagnosed multiple myeloma. Journal of B.U.ON. [Internet]. 2015;20(5):1314 - 1321. WebsiteAbstract
Purpose: Maximizing the response rate to first-line therapy in patients with multiple myeloma (MM) is important because it leads to improved outcome. Gene-expression studies have identified prognostic gene sets in patients receiving bortezomib-based therapy. Comparison of the lists of genes derived from two gene-expression-based models (GEP70, GEP80) showed that they overlap in three genes, namely PSMD4, BIRC5, and KIAA1754. An unanswered question is whether early gene-expression changes can be used as predictors of the response to first-line bortezomib. In this study we aimed to examine the predictive value of gene expression changes for the depth of response after bortezomib-based therapy in newly diagnosed MM. Methods: We prospectively assessed the relation between early PSMD4, BIRC5, and KIAA1754 gene expression changes (before therapy and one week later) and the response rate after bortezomib-based therapy in 25 patients with newly diagnosed MM. Gene expression was studied by RT-PCR on CD138-selected plasma cells, and changes were recorded as upregulation, downregulation, or unchanged. Results: Whereas baseline prognostic factors including genetic lesions and stage were not predictive of the response rate, we found that early BIRC5 and KIAA1754 gene-expression changes were significantly associated with the depth of response to bortezomib (p=0.001 and p<0.001, respectively). PSMD4 was not predictive of the depth of response. KIAA1754 upregulation was linked to complete remission (CR) or very good partial remission (VGPR). BIRC5 upregulation was linked to stable disease (SD) or progressive disease (PD). We also observed that BIRC5 upregulation was associated with worse progression-free survival (PFS). Conclusions: Our results suggest that BIRC5 and KIAA1754 gene-expression changes may predict the response to bortezomib-based therapy. These data may have relevance for the stratification and early adaptation of first-line treatment in patients with newly diagnosed MM.
Kamberidou I. The East in the Eyes of Western Women Travellers of the 18th and 19th Centuries: Solidarity and Understanding the East. Proceedings (pp. 285-311) of the International Conference ‘The East in the Eyes of the West’, Nov. 26-28, 2013. Under the Patronage of the President of Kuwait University, published May 2015. 2015:285–311.Abstract
   "It also may be said that in our travels we saw only the bright side of Islam. Well! That is just what we desired to see; … The fact of it is, we had heard quite enough of the dark side of Islam, so we determined to pursue our studies on the side looking to the sun … Is it right, fair, or just, to visit other people in their homes, or in their countries, wherever they dwell, and come away to decry them? No! It is not right!" argues Emilie Hayacinthe Loyson, after her travels in Oriental lands in the years 1894-1896. Women travellers from Great Britain, France, Germany, Switzerland, Sweden, Austria and America explored, visited, worked and resided in regions of the East that were considered “proper and safe for dynamic men only” (Smith, 1887). The mammoth body of writings by women travellers of the 18th and 19th centuries, that claim to be eyewitness descriptions of the female microcosmos, provide a rich and detailed interpretation of the Orient, including a feminine version, a female gaze. European and American women identified with the so-called Other, expressed their solidarity and participated in Muslim women’s daily domestic life, customs, female social gatherings, religious celebrations and feasts. As a result, they accused male travellers- who had written about domestic manners in the East and the position of women in Islam of misinforming or mis or misleading their readers, stressing that their accounts were based on second or third-hand information, their unrestrained imagination and exotic fantasies.  
kuwait_university_proceedings_2015.pdf the_east_in_the_eyes_of_the_west.pdf
Matsangouras I, Kalogiros I, Nastos PT, Anagnostou MN, Pytharoulis I, Bluestein HB. ECSS 2015. 2015.
Mateos MV, Richardson PG, Dimopoulos MA, Palumbo A, Anderson KC, Shi H, Elliott J, Dow E, van de Velde H, Niculescu L, et al. Effect of cumulative bortezomib dose on survival in multiple myeloma patients receiving bortezomib-melphalan-prednisone in the phase III VISTA study. American Journal of Hematology [Internet]. 2015;90(4):314 - 319. WebsiteAbstract
This analysis, using data from the bortezomib-melphalan-prednisone (VMP) arm of the Phase III VISTA study, investigated whether increased cumulative bortezomib dose could improve overall survival (OS) in transplant-ineligible patients with previously untreated multiple myeloma. Median cumulative bortezomib dose received by the 340 patients was 39 mg/m2; this was selected as the cut-off for defining the dose groups to be compared for OS. Patient characteristics were well balanced between dose groups except for age. OS was significantly longer in the higher (≥39 mg/m2) versus lower (<39 mg/m2) cumulative bortezomib dose group (median 66.3 vs. 46.2 months; hazard ratio (HR) 0.533, P<0.0001; age-adjusted HR 0.561, P=0.0002). To overcome confounding effects of early discontinuations/deaths, which were more common in the lower cumulative dose group (27 vs. 4% of patients discontinued due to adverse events (AEs) in the lower and higher cumulative dose groups, respectively), a landmark analysis was conducted at 180 days, eliminating patients who died or discontinued before this time from the analysis. OS from this landmark remained significantly longer in the higher dose group (median 60.4 vs. 50.3 months; HR 0.709, P=0.0372). Thus, higher cumulative bortezomib dose, reflecting prolonged treatment duration and/or dose intensity, appears associated with improved OS. Approaches to achieve higher cumulative doses could include subcutaneous bortezomib administration, dose/schedule modifications, continuing therapy in responding patients, and proactive AE management. © 2015 Wiley Periodicals, Inc.
Kanapitsas, A. BAMAAP. Effect of γ-radiation on the production of aflatoxin B1 by Aspergillus parasiticus in raisins (Vitis vinifera L.). Radiation Physics and Chemistry [Internet]. 2015;106:327-332. Website
Raptopoulou, K.G. PTPINNS. The effects of food processing and canning technologies on the nutritional value of foods.; 2015 pp. 117-131. Website
Sagonas K, Pafilis P, Valakos ED. Effects of insularity on digestion: living on islands induces shifts in physiological and morphological traits in island reptiles. Naturwissenschaften. 2015;102(9-10):55.Abstract
Living on islands entails numerous challenges for animals, among which resource scarcity stands out. In order to survive, animals have to optimize energy acquisition. We examined the impact of insularity on digestion comparing a series of physiological and morphological traits of adult males between insular and mainland populations of the Balkan green lizard. Island lizards had longer gastrointestinal tracts and gut passage times and higher digestive efficiencies. The dissection of the hindgut revealed an unexpected finding, the presence of cecal valves that were more frequent in island lizards. Thanks to all above islanders retain food for longer periods and thus maximize energy income and increase the amount of the extracted nutrients. That way, they secure energy income from the limited, in time and quantity, food resources of the islands.
Karamanou M, Papaioannou TG, Tsoucalas G, Laios K, Androutsos G. Electromagnetic machines in cancer treatment: The "Priore Affair". Journal of B.U.ON. [Internet]. 2015;20(3):936 - 939. Website
Zenetos A, Arianoutsou, M., Bazos, I., Balopoulou, S., Corsini-Foka, M., Dimiza, M., Drakopoulou, P., Katsanevakis, S., Kondylatos, G., Koutsikos N, et al. ELNAIS: A collaborative network on Aquatic Alien Species in Hellas (Greece). Management of Biological Invasions [Internet]. 2015;6(2):185–196. Publisher's VersionAbstract
ELNAIS is a dynamic online information platform aiming to collect and report spatial information on Aquatic Alien Species in Greek waters. It covers freshwater, marine and estuarine waters, including not only established aliens but also casual records and cryptogenic species. The ELNAIS system includes: News, List of Greek experts, Literature of findings in Greece, List of species with information on their first introduction date and source as well as photos and distribution maps. Data providers are the scientific community (publications, grey literature, and databases) as well as citizen scientists. ELNAIS provides a useful tool towards national obligations and commitments under both the European and global frameworks in respect to Non Indigenous Species (CBD, WFD, MSFD).
Lonial S, Dimopoulos M, Palumbo A, White D, Grosicki S, Spicka I, Walter-Croneck A, Moreau P, Mateos M-V, Magen H, et al. Elotuzumab therapy for relapsed or refractory multiple myeloma. New England Journal of Medicine [Internet]. 2015;373(7):621 - 631. WebsiteAbstract
Background: Elotuzumab, an immunostimulatory monoclonal antibody targeting signaling lymphocytic activation molecule F7 (SLAMF7), showed activity in combination with lenalidomide and dexamethasone in a phase 1b-2 study in patients with relapsed or refractory multiple myeloma. Methods: In this phase 3 study, we randomly assigned patients to receive either elotuzumab plus lenalidomide and dexamethasone (elotuzumab group) or lenalidomide and dexamethasone alone (control group). Coprimary end points were progression-free survival and the overall response rate. Final results for the coprimary end points are reported on the basis of a planned interim analysis of progression-free survival. Results: Overall, 321 patients were assigned to the elotuzumab group and 325 to the control group. After a median follow-up of 24.5 months, the rate of progression-free survival at 1 year in the elotuzumab group was 68%, as compared with 57% in the control group; at 2 years, the rates were 41% and 27%, respectively. Median progression-free survival in the elotuzumab group was 19.4 months, versus 14.9 months in the control group (hazard ratio for progression or death in the elotuzumab group, 0.70; 95% confidence interval, 0.57 to 0.85; P<0.001). The overall response rate in the elotuzumab group was 79%, versus 66% in the control group (P<0.001). Common grade 3 or 4 adverse events in the two groups were lymphocytopenia, neutropenia, fatigue, and pneumonia. Infusion reactions occurred in 33 patients (10%) in the elotuzumab group and were grade 1 or 2 in 29 patients. Conclusions: Patients with relapsed or refractory multiple myeloma who received a combination of elotuzumab, lenalidomide, and dexamethasone had a significant relative reduction of 30% in the risk of disease progression or death. Copyright © 2015 Massachusetts Medical Society. All rights reserved.
Tzoupis H, Leonis G, Avramopoulos A, Reis H, Czyznikowska Z, Zerva S, Vergadou N, Peristeras LD, Papavasileiou KD, Alexis MN, et al. Elucidation of the binding mechanism of renin using a wide array of computational techniques and biological assays. Journal of Molecular Graphics and Modelling [Internet]. 2015;62:138 - 149. Website
<em>Relocating the History of Science: Essays in Honor of Kostas Gavroglu</em>
Relocating the History of Science: Essays in Honor of Kostas Gavroglu. 1st ed. (Arabatzis T, Renn J, Simões A). Dordrecht: Springer; 2015 pp. vii + 383. Publisher's Version
Βαβουρανάκης Γιώργος. Εικόνα και αρχαιολογία. Η περίπτωση της προϊστορικής αρχιτεκτονικής. Μέρος Α. Αθήνα: Κάλλιπος; 2015 pp. 260. Publisher's Version
Paraskevis D, Paraschiv S, Sypsa V, Nikolopoulos G, Tsiara C, Magiorkinis G, Psichogiou M, Flampouris A, Mardarescu M, Niculescu I, et al. Enhanced HIV-1 surveillance using molecular epidemiology to study and monitor HIV-1 outbreaks among intravenous drug users (IDUs) in Athens and Bucharest. Infect Genet Evol. 2015;35:109-21.Abstract
BACKGROUND: A significant increase in HIV-1 diagnoses was reported among Injecting Drug Users (IDUs) in the Athens (17-fold) and Bucharest (9-fold) metropolitan areas starting 2011. METHODS: Molecular analyses were conducted on HIV-1 sequences from IDUs comprising 51% and 20% of the diagnosed cases among IDUs during 2011-2013 for Greece and Romania, respectively. Phylodynamic analyses were performed using the newly developed birth-death serial skyline model which allows estimating of important epidemiological parameters, as implemented in BEAST programme. RESULTS: Most infections (>90%) occurred within four and three IDU local transmission networks in Athens and Bucharest, respectively. For all Romanian clusters, the viral strains originated from local circulating strains, whereas in Athens, the local strains seeded only two of the four sub-outbreaks. Birth-death skyline plots suggest a more explosive nature for sub-outbreaks in Bucharest than in Athens. In Athens, two sub-outbreaks had been controlled (Re<1.0) by 2013 and two appeared to be endemic (Re∼1). In Bucharest one outbreak continued to expand (Re>1.0) and two had been controlled (Re<1.0). The lead times were shorter for the outbreak in Athens than in Bucharest. CONCLUSIONS: Enhanced molecular surveillance proved useful to gain information about the origin, causal pathways, dispersal patterns and transmission dynamics of the outbreaks that can be useful in a public health setting.
Zagouri F, Sergentanis TN, Chrysikos D, Dimopoulos M-A, Bamias A. Epothilones in epithelial ovarian, fallopian tube, or primary peritoneal cancer: A systematic review. OncoTargets and Therapy [Internet]. 2015;8:2187 - 2198. WebsiteAbstract
Ovarian cancer is the most lethal gynecologic malignancy; consequently, there is a need for effective therapies. Epothilones are microtubule-stabilizing agents that inhibit cell growth. Currently, patupilone and its four synthetic derivatives ixabepilone, BMS-310705, sagopilone, 20-desmethyl-20-methylsulfanyl epothilone B and epothilone D, as well as its derivative KOS-1584, are under clinical evaluation. This is the first systematic review conducted in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta- Analyses) guidelines that synthesizes all available data emerging from trials and evaluates the efficacy and safety of epothilones in epithelial ovarian, primary fallopian tube, and primary peritoneal cancer. Despite the fact that epothilones have proven active in taxane-resistant settings in preclinical models, it is not yet clear from Phase II/III studies reviewed here that their clinical activity is superior to that of taxanes. Nevertheless, responses to epothilones have been observed in platinum-refractory/resistant ovarian cancer patients. Moreover, despite the shared mechanism of action of epothilones, their clinical profile seems clearly different, with diarrhea being the most common dose-limiting toxicity encountered with patupilone, whereas neutropenia and sensory neuropathy are the most common toxic effects observed with the other epothilones. In any case, randomized trials comparing epothilones with standard treatments seem warranted to define further the role of these agents, whereas biomarker analysis might further optimize patient selection. © 2015 Zagouri et al.
Terpos E, Kleber M, Engelhardt M, Zweegman S, Gay F, Kastritis E, Van De Donk NWCJ, Bruno B, Sezer O, Broij A, et al. European myeloma network guidelines for the management of multiple myeloma-related complications. Haematologica [Internet]. 2015;100(10):1254 - 1266. WebsiteAbstract
The European Myeloma Network provides recommendations for the management of the most common complications of multiple myeloma. Whole body low-dose computed tomography is more sensitive than conventional radiography in depicting osteolytic disease and thus we recommend it as the novel standard for the detection of lytic lesions in myeloma (grade 1A). Myeloma patients with adequate renal function and bone disease at diagnosis should be treated with zoledronic acid or pamidronate (grade 1A). Symptomatic patients without lytic lesions on conventional radiography can be treated with zoledronic acid (grade 1B), but its advantage is not clear for patients with no bone involvement on computed tomography or magnetic resonance imaging. In asymptomatic myeloma, bisphosphonates are not recommended (grade 1A). Zoledronic acid should be given continuously, but it is not clear if patients who achieve at least a very good partial response benefit from its continuous use (grade 1B). Treatment with erythropoietic-stimulating agents may be initiated in patients with persistent symptomatic anemia (hemoglobin <10g/dL) in whom other causes of anemia have been excluded (grade 1B). Erythropoietic agents should be stopped after 6-8 weeks if no adequate hemoglobin response is achieved. For renal impairment, bortezomib-based regimens are the current standard of care (grade 1A). For the management of treatment-induced peripheral neuropathy, drug modification is needed (grade 1C). Vaccination against influenza is recommended; vaccination against streptococcus pneumonia and hemophilus influenza is appropriate, but efficacy is not guaranteed due to suboptimal immune response (grade 1C). Prophylactic aciclovir (or valacyclovir) is recommended for patients receiving proteasome inhibitors, autologous or allogeneic transplantation (grade 1A). © 2015 Ferrata Storti Foundation.
Michopoulou E, Nikita E, Valakos ED. Evaluating the efficiency of different recording protocols for entheseal changes in regards to expressing activity patterns using archival data and cross-sectional geometric properties. Am J Phys Anthropol. 2015;158(4):557-68.Abstract
OBJECTIVES: In the past decade there have been extensive discussions on the potential utility of entheseal changes (EC) as activity markers. Nevertheless, no study to date has compared different EC recording protocols with respect to their correlation to activity patterns. MATERIALS AND METHODS: This article records changes on fibrocartilaginous entheses of the upper limbs of 90 male skeletons from the documented Athens Collection using the Hawkey and Merbs (Int J Osteoarchaeol 5 (1995) 324-338), Mariotti et al. (Collegium Antropol 28 (2004) 145-159), and Villotte et al. (Am J Phys Anthropol 142 (2010) 224-234) recording schemes in order to determine which one exhibits the highest correlation with activity. Activity is assessed by means of the recorded profession of each individual, as well as employing cross-sectional geometric properties. Generalized Linear Models are used to explore the impact of age, body mass, and activity on EC expression. RESULTS: Our results agree with previous studies that age is the primary factor determining EC, whereas body mass is the second most influential factor. In contrast, activity in the form of profession or cross-sectional geometry rarely showed a significant correlation to EC expression and no clear pattern could be discerned irrespective of the recording technique. However, bilateral differences in the impact of age and body mass in EC expression were traced and may relate to activity patterns. CONCLUSIONS: The differences found in the bilateral impact of age and body mass highlight the fact that the activity patterns of the individuals under examination must play an underlying role to EC expression, though current recording schemes for EC do not capture this, rendering further work in the direction of developing more elaborate recording standards imperative.
Kountouris P, Drikos S, Aggelonidis I, Laios A, Kyprianou M. Evidence for differences in men’s and women’s volleyball games based on skills effectiveness in four consecutive Olympic tournaments. Comprehensive Psychology. 2015;4:Article–9. final_article.pdf
Diriken J, Patronis N, Andreyev A, Antalic S, Bildstein V, Blazhev A, Darby IG, De Witte H, Eberth J, Elseviers J, et al. Experimental study of the $^{66}\mathrm{Ni}(d,p) ^{67}\mathrm{Ni}$ one-neutron transfer reaction. Phys. Rev. C. 2015;91:054321.
Vrontaki E, Melagraki G, Mavromoustakos T, Afantitis A. Exploiting ChEMBL database to identify indole analogs as HCV replication inhibitors. Methods [Internet]. 2015;71(C):4 - 13. Website
Saragas N, Floros G, Raptopoulos G, Pitsikalis M, Paraskevopoulou P, Mertis K. Exploring the Reactivity of Na [W2 (μ-Cl) 3Cl4 (THF) 2]∙(THF) 3 towards the Polymerization of Selected Cycloolefins. Molecules. 2015;20(12):21896-21908.
Saragas N, Floros G, Raptopoulos G, Pitsikalis M, Paraskevopoulou P, Mertis K. Exploring the Reactivity of Na[W2($\upmu$-Cl)3Cl4({THF})2]$\vysmblkcircle$({THF})3 towards the Polymerization of Selected Cycloolefins. Molecules [Internet]. 2015;20:21896–21908. PDF
Giannos A, Filipits M, Zagouri F, Brandstetter A, Tsigginou A, Sotiropoulou M, Papaspyrou I, Sergentanis TN, Psaltopoulou T, Rodolakis A, et al. Expression of ARs in triple negative breast cancer tumors: A potential prognostic factor?. OncoTargets and Therapy [Internet]. 2015;8:1843 - 1847. WebsiteAbstract
Background/aim: In light of the controversial published literature, this study aims to examine the potential prognostic role of AR immunohistochemical expression in triple negative breast cancer (TNBC). Patients and methods: Ninety patients with TNBC were included in this study; the associations between AR expression (Allred score), clinicopathological variables (stage, grade, histological subtype, tumor size, nodal status, age at diagnosis, Ki67 expression, and p53 expression), and overall survival were evaluated. Results: AR expression was not associated with stage, grade, histological subtype, tumor size, nodal status, age at diagnosis, Ki67 expression, and p53 expression. AR immunopositivity was not associated with overall survival either at the univariate or at the multivariate Cox regression analysis (multivariate hazard ratio =0.66, 95% confidence interval: 0.26–1.70, P=0.393). Conclusion: AR expression does not seem to play a prognostic role in TNBC. © 2015 Giannos et al.
Vavuranakis M, Vrachatis DA, Siasos G, Vaina S, Filis K, Sigala F, Kalogeras K, Kolokathis A-M, Moldovan C, Papaioannou TG, et al. First in Greece transcatheter aortic valve implantation using the CoreValve evolut-R retrievable and repositionable bioprosthesis with the inline sheath and the EnVeo loading guiding catheter: A major advantage for small- diameter access vessels. Hellenic Journal of Cardiology [Internet]. 2015;56(4):338 - 343. Website
The Fragmented Environment of Interwar Halkidiki
Gardikas K. The Fragmented Environment of Interwar Halkidiki. In: Gounaris BC Gounaris, Basil C. ed. Mines, Olives and Monasteries. Aspects of Halkidiki's Environmental History. Thessaloniki: Epikentro, Pharos Books; 2015. pp. 163-183.
Zagouri F, Sergentanis TN, Chrysikos D, Dimopoulos M-A, Psaltopoulou T. Fulvestrant and male breast cancer: a pooled analysis. Breast Cancer Research and Treatment [Internet]. 2015;149(1):269 - 275. WebsiteAbstract
Male breast cancer is an uncommon malignancy; little is known regarding hormonal manipulations for tamoxifen-resistant male breast cancer patients. This is the first pooled analysis of the literature to synthesize all available data and to evaluate the efficacy and safety of fulvestrant in male breast cancer. This study was performed in accordance with the PRISMA guidelines. All studies that examined the efficacy of fulvestrant in male breast cancer, regardless of sample size, were considered eligible. The search strategy retrieved 31 articles; of these, five articles were eligible (23 patients) for this pooled analysis. The mean age of the study sample was 63.1 years. Adjuvant hormonal treatment was administered in 87.5 % of cases. Fulvestrant was given as first or second line in 40 % of patients, while as third line or beyond in 60 % of patients. 79.0 % of patients at fulvestrant administration had visceral metastases. Regarding best response, in 26.1 % PR was achieved, in 47.8 % of cases SD was recorded, whereas in 26.1 % of patients PD was noted. The median PFS was equal to 5 months. No grade 3 and 4 adverse events were recorded; of note, hot flashes were reported in 18.2 % of male breast cancer patients. Fulvestrant may potentially play a promising role in the optimal therapeutic strategy for male patients with breast cancer diagnosis. However, further clinical and pharmacokinetic investigations are more than warranted before fulvestrant use becomes a common practice in male breast cancer patients. © 2014, Springer Science+Business Media New York.
Mitsi E. George Chapman’s “ancient Greek souls”: translating ekphrasis in Hero and Leander. Word & Image. 2015;31(3):343-349.
Palumbo A, Bringhen S, Mateos M-V, Larocca A, Facon T, Kumar S, Offidani M, McCarthy P, Evangelista A, Lonial S, et al. Geriatric assessment predicts survival and toxicities in elderly myeloma patients: An International Myeloma Working Group report. Blood [Internet]. 2015;125(13):2068 - 2074. WebsiteAbstract
We conducted a pooled analysis of 869 individual newly diagnosed elderly patient data from 3 prospective trials. At diagnosis, a geriatric assessment had been performed. An additive scoring system (range 0-5), based on age, comorbidities, and cognitive and physical conditions, was developed to identify 3 groups: fit (score = 0, 39%), intermediate fitness (score = 1,31%), and frail (score ≥2, 30%). The 3-year overall survivalwas 84%in fit, 76% in intermediate-fitness (hazard ratio [HR], 1.61; P = .042), and 57% in frail (HR, 3.57; P < .001) patients. Thecumulative incidence of grade ≥3 nonhematologic adverse events at 12 months was 22.2%in fit, 26.4%in intermediate-fitness (HR, 1.23; P = .217), and 34.0%in frail (HR, 1.74; P < .001) patients. The cumulative incidence of treatment discontinuation at 12months was 16.5%in fit, 20.8%in intermediate-fitness (HR, 1.41; P = .052), and 31.2% in frail (HR, 2.21; P < .001) patients. Our frailty score predicts mortality and the risk of toxicity in elderly myeloma patients. The International Myeloma Working group proposes this score for the measurement of frailty in designing future clinical trials. These trials are registered at www.clinicaltrials.gov as #NCT01093136 (EMN01), #NCT01190787 (26866138MMY2069), and #NCT01346787 (IST-CAR-506).
Angelis K, Albert J, Mamais I, Magiorkinis G, Hatzakis A, Hamouda O, Struck D, Vercauteren J, Wensing AMJ, Alexiev I, et al. Global Dispersal Pattern of HIV Type 1 Subtype CRF01_AE: A Genetic Trace of Human Mobility Related to Heterosexual Sexual Activities Centralized in Southeast Asia. J Infect Dis. 2015;211(11):1735-44.Abstract
BACKGROUND: Human immunodeficiency virus type 1 (HIV-1) subtype CRF01_AE originated in Africa and then passed to Thailand, where it established a major epidemic. Despite the global presence of CRF01_AE, little is known about its subsequent dispersal pattern. METHODS: We assembled a global data set of 2736 CRF01_AE sequences by pooling sequences from public databases and patient-cohort studies. We estimated viral dispersal patterns, using statistical phylogeographic analysis run over bootstrap trees estimated by the maximum likelihood method. RESULTS: We show that Thailand has been the source of viral dispersal to most areas worldwide, including 17 of 20 sampled countries in Europe. Japan, Singapore, Vietnam, and other Asian countries have played a secondary role in the viral dissemination. In contrast, China and Taiwan have mainly imported strains from neighboring Asian countries, North America, and Africa without any significant viral exportation. DISCUSSION: The central role of Thailand in the global spread of CRF01_AE can be probably explained by the popularity of Thailand as a vacation destination characterized by sex tourism and by Thai emigration to the Western world. Our study highlights the unique case of CRF01_AE, the only globally distributed non-B clade whose global dispersal did not originate in Africa.
Andersen JP, Bøgsted M, Dybkær K, Mellqvist U-H, Morgan GJ, Goldschmidt H, Dimopoulos MA, Einsele H, San Miguel J, Palumbo A, et al. Global myeloma research clusters, output, and citations: A bibliometric mapping and clustering analysis. PLoS ONE [Internet]. 2015;10(1). WebsiteAbstract
Background: International collaborative research is a mechanism for improving the development of dis-ease- specific therapies and for improving health at the population level. However, limited data are available to assess the trends in research output related to orphan diseases. Methods and Findings: We used bibliometric mapping and clustering methods to illustrate the level of fragmentation in myeloma research and the development of collaborative efforts. Publication data from Thomson Reuters Web of Science were retrieved for 2005-2009 and followed until 2013. We created a database of multiple myeloma publications, and we analysed impact and coauthorship density to identify scientific collaborations, developments, and international key players over time. The global annual publication volume for studies on multiple myeloma increased from 1,144 in 2005 to 1,628 in 2009, which represents a 43% increase. This increase is high compared to the 24% and 14% increases observed for lymphoma and leukaemia. The major proportion (>90% of publications) was from the US and EU over the study period. The output and impact in terms of citations, identified several successful groups with a large number of intra-cluster collaborations in the US and EU. The US-based myeloma clusters clearly stand out as the most productive and highly cited, and the European Myeloma Network members exhibited a doubling of collaborative publications from 2005 to 2009, still increasing up to 2013. Conclusion and Perspective: Multiple myeloma research output has increased substantially in the past decade. The fragmented European myeloma research activities based on national or regional groups are progressing, but they require a broad range of targeted research investments to improve multiple myeloma health care. © 2015 Andersen et al.
Nikiforidou K. Grammatical constructions and cross-text generalizations: Empathetic narration as genre. Constructions and Frames. 2015;7(2):187-217.Abstract
This paper investigates two tense-based constructions in English and Greek and one complementation construction in Greek, whose import is to effect a deictic shift and allow narration to proceed from the point of view of the narrated events and a participant therein. In addition to the individual formal and discourse-pragmatic properties of the patterns at hand, I focus on properties of the embedding context, showing that these unrelated constructions impose similar formal and interpretational requirements. This, in turn, supports the statement of generalizations at the level of genre, in this case ‘empathetic narration’ as a special kind of narration that departs from the default past narrative deictically anchored to the narrator and the conversational coordinates. While the analysis adopts a bottom-up, language-driven approach to genre, it also refutes an exhaustive equation with linguistic conventions, arguing that a Bakhtinian view of genre, which includes both linguistic and socio-cultural dimensions, is more appropriate for the data at hand.
Eberl H, Spanos VC. {GravitinoPack and decays of supersymmetric metastable particles}. 2015.
Eberl H, Spanos VC. {GravitinoPack and late decays involving gravitinos}. {18th International Conference From the Planck Scale to the Electroweak Scale (Planck 2015) Ioannina, Greece, May 25-29, 2015}. 2015;PLANCK2015:124.
Kamberidou I. 'GYMNAST’S ANTHEM' translated from Greek into English by Irene Kamberidou, May 11, 2015 for the concert ‘Music and Athletics,’ the opening ceremony of the “Genomics, Genetics and Exercise Biology” Symposium, Great Hall of the University of Athen. ΥΜΝΟΣ ΓΥΜΝΑΣΤΩΝ του Μενέλαου Παλλάντιου. Μεταφράστηκε 11/5/2015/ από την Ειρήνη Καμπερίδου για τη συναυλία ΜΟΥΣΙΚΗ ΚΑΙ ΑΘΛΗΤΙΣΜΟΣ, Αίθουσα Τελετών του Εθνικού και Καποδιστριακού Πανεπιστημίου Αθηνών) στο πλαίσιο της τελετής έναρξης του συνεδρίου “Genomics. 2015. gymnasts_anthem_in_english.pdf
Morphis G, Kyriazopoulou A, Nasopoulou C, Sioriki E, Demopoulos C, Zabetakis I.

Assessment of the in Vitro Antithrombotic Properties of Sardine (Sardina pilchardus) Fillet Lipids and Cod Liver Oil

. Fishes [Internet]. 2015;1:1-15. Publisher's VersionAbstract
The aim of the current study was to compare the biological activities of total polar lipids (TPL) and thin-layer chromatography (TLC) polar lipid fractions of sardine fillet and cod liver oil against atherogenesis. TPL and TLC polar lipid fractions obtained from these two sources were assessed for their ability to inhibit the platelet-activating-factor (PAF)-induced platelet aggregation (PAF-antagonists) or to induce platelet aggregation (PAF-agonists), since PAF plays a crucial role in the initiation and development of atherosclerosis. This study focused on the polar lipids since previous studies have underlined that the antithrombotic properties of foodstuffs are mainly attributed to polar lipid micro-constituents. TPL of sardine fillet induced platelet aggregation, while TPL of cod liver had a bimodal effect on platelets. TLC polar lipid fractions of both samples exhibited in vitro aggregatory and inhibitory activity towards platelets. However, TLC sardine polar lipid fractions showed stronger in vitro antithrombotic activities than the cod liver oil ones. These data constitute evidence of the putative contribution of fish polar lipids against cardiovascular diseases, underling firstly the beneficial effect of fish and fish lipids as functional foodstuffs against atherogenesis and secondly the more important role of sardine polar lipids as opposed to cod liver oil.
fishes.pdf
Balios D, Eriotis N, Fragoudaki A, Giokas D.

Economic efficiency of Greek retail SMEs in a period of high fluctuations in economic activity: a DEA approach
. Applied Economics [Internet]. 2015;47(33):3577-3593. Publisher's VersionAbstract
This study aims to analyse the economic efficiency of Greek small and medium retail enterprises before and after the crisis that started in 2008. Based on the Accounting Equation, we use Data Envelopment Analysis (DEA) to estimate variable returns of scale efficiency scores and to conclude on specific characteristics that efficient companies have, for example, on capital structure. Our results from the DEA application show a high degree of inefficiency. We found that SMEs on the islands are more efficient than those on the mainland and that SMEs in the cities are the least efficient. Size seems to be important, more so on the islands and on the mainland than in the cities. We conclude that companies should act more conservatively in terms of operating cost when the first signs of a recession appear. In addition, during a recession period, companies that have evidences that their operations will continue positively should strengthen their operations by raising more own capital. Finally, our study clarifies four issues: the efficiency of retail companies in a period of growth and a period of recession, focusing on SMEs that operate in different regions, connecting Accounting Equation and DEA and adding acid ratio as an output in our model.
Song KW, Dimopoulos MA, Weisel KC, Moreau P, Palumbo A, Belch A, Schey S, Sonneveld P, Sternas L, Yu X, et al. Health-RELATED quality of life from the MM-003 trial of pomalidomide plus LOW-Dose dexamethasone VERSUS HIGH-DOSE dexamethasone in relapsed and/or refractory multiple myeloma. Haematologica [Internet]. 2015;100(2):63 - 67. Website
Kanellakopoulos A, Angelinos N, Madesis I, Zouros TJM, Fernández-Martín M, Martínez G, Mertzimekis TJ. Hemispherical Deflector Analyzer input lens optimization using SIMION. [Internet]. 2015. Website
Sypsa V, Paraskevis D, Malliori M, Nikolopoulos GK, Panopoulos A, Kantzanou M, Katsoulidou A, Psichogiou M, Fotiou A, Pharris A, et al. Homelessness and Other Risk Factors for HIV Infection in the Current Outbreak Among Injection Drug Users in Athens, Greece. Am J Public Health. 2015;105(1):196-204.Abstract
Objectives. We examined HIV prevalence and risk factors among injection drug users (IDUs) in Athens, Greece, during an HIV outbreak. Methods. We used respondent-driven sampling (RDS) to recruit 1404 IDUs to the Aristotle intervention in August to October 2012. We interviewed participants and tested for HIV. We performed bivariate and multivariate analyses. Results. Estimated HIV prevalence was 19.8% (RDS-weighted prevalence = 14.8%). Odds of infection were 2.3 times as high in homeless as in housed IDUs and 2.1 times as high among IDUs who injected at least once per day as among less frequent injectors (both, P < .001). Six percent of men and 23.5% of women reported transactional sex in the past 12 months, and condom use was low. Intercourse with non-IDUs was common (53.2% of men, 25.6% of women). Among IDUs who had been injecting for 2 years or less the estimated incidence rate was 23.4 new HIV cases per 100 person-years at risk. Conclusions. Efforts to reduce HIV transmission should address homelessness as well as scaling up prevention services, such as needle and syringe distribution and other risk reduction interventions.
Papaioannou, C.D. SSPKLVJIF. Impact of different preservation treatments on lipids of the smooth clam Callista chione. International Journal of Food Science and Technology [Internet]. 2015. Website
Dimopoulos MA, Petrucci MT, Foà R, Catalano J, Kropff M, Terpos E, Zhang J, Grote L, Jacques C, Palumbo A. Impact of maintenance therapy on subsequent treatment in patients with newly diagnosed multiple myeloma: Use of “progression-free survival 2” as a clinical trial end-point. Haematologica [Internet]. 2015;100(8):e328 - e330. Website
San Miguel JF, Weisel KC, Song KW, Delforge M, Karlin L, Goldschmidt H, Moreau P, Banos A, Oriol A, Garderet L, et al. Impact of prior treatment and depth of response on survival in MM-003, a randomized phase 3 study comparing pomalidomide plus low-dose dexamethasone versus high-dose dexamethasone in relapsed/refractory multiple myeloma. Haematologica [Internet]. 2015;100(10):1334 - 1339. WebsiteAbstract
Pomalidomide is a distinct oral IMiD® immunomodulatory agent with direct antimyeloma, stromal-support inhibitory, and immunomodulatory effects. The pivotal, multicenter, open-label, randomized phase 3 trial MM-003 compared pomalidomide + low-dose dexamethasone vs high-dose dexamethasone in 455 patients with refractory or relapsed and refractory multiple myeloma after failure of bortezomib and lenalidomide treatment. Initial results demonstrated significantly longer progression-free survival and overall survival with an acceptable tolerability profile for pomalidomide + low-dose dexamethasone vs high-dose dexamethasone. This secondary analysis describes patient outcomes by treatment history and depth of response. Pomalidomide + low-dose dexamethasone significantly prolonged progression-free survival and favored overall survival vs high-dose dexamethasone for all subgroups analyzed, regardless of prior treatments or refractory status. Both univariate and multivariate analyses showed that no variable relating to either the number (≤ or > 3) or type of prior treatment was a significant predictor of progression-free survival or overall survival. No cross-resistance with prior lenalidomide or thalidomide treatment was observed. Patients achieving a minimal response or better to pomalidomide + low-dose dexamethasone treatment experienced a survival benefit, which was even higher in those achieving at least a partial response (17.2 and 19.9 months, respectively, as compared with 7.5 months for patients with less than minimal response). These data suggest that pomalidomide + low-dose dexamethasone should be considered a standard of care in patients with refractory or relapsed and refractory multiple myeloma regardless of prior treatment. ClinicalTrials.gov: NCT01311687; EudraCT: 2010-019820-30. © 2015 Ferrata Storti Foundation.
Papaioannou TG, Vardoulis O, Protogerou A, Konstantonis G, Sfikakis PP, Stefanadis C, Stergiopulos N. In vivo evaluation of a novel 'diastole-patching' algorithm for the estimation of pulse transit time: Advancing the precision in pulse wave velocity measurement. Physiological Measurement [Internet]. 2015;36(1):149 - 161. Website
Maniadakis D, Varoutas D. Incorporating Gabriel graph model for FTTx dimensioning. Photonic Network Communications. 2015;29:214–226.
Balikou P, Gourtzelidis P, Mantas A, Moutoussis K, Evdokimidis I, Smyrnis N. Independent sources of anisotropy in visual orientation representation: a visual and a cognitive oblique effect. Experimental brain research. 2015;233:3097–3108.
Lambrinoudaki I, Armeni E, Rizos D, Georgiopoulos G, Athanasouli F, Triantafyllou N, Panoulis K, Augoulea A, Creatsa M, Alexandrou A, et al. Indices of adiposity and thyroid hormones in euthyroid postmenopausal women. European Journal of Endocrinology. 2015;173(2):237 - 245.Abstract
© 2015 European Society of Endocrinology. Objective: We aimed to evaluate the association between thyroid hormones and indices of obesity in a sample of euthyroid postmenopausal women. Design: Cross-sectional study. Methods: Serum levels of TSH, free triiodothyronine (FT3), and free thyroxine (FT4) as well as BMI and waist:hip ratio (WHR) were evaluated in 194 healthy euthyroid postmenopausal women. Ultrasonography was used to assess abdominal fat layers (subcutaneous fat (SF), preperitoneal fat (PF), and SF:PF ratio). Indices of adiposity were defined as high vs low depending on the median value of the assessed parameters. Results: After multivariate adjustment for traditional risk factors, lower FT4 levels and a higher FT3:FT4 ratio predicted higher SF mass (FT4, Exp(β)=0.035, P=0.020 and FT3:FT4, Exp(β)=2.374, P=0.018), whereas higher FT3 predicted higher PF mass (Exp(β)=2.815, P=0.032). Women with FT3:FT4 above the highest quartile had a significantly higher SF mass as compared to women in the lowest quartile (1.81±0.62 cm vs 1.54∓0.46 cm, P=0.027). BMI had a positive independent association with TSH (Exp(β)=1.829, P=0.018). Finally, FT3 was significantly associated with SF mass among women with higher BMI (FT3, β=0.259, P=0.040) and women with higher WHR (β=0.309, P=0.020) but not among women with lower BMI or WHR values. Conclusion: Thyroid hormone levels, and in particular FT3, were independently associated with SF and PF in euthyroid postmenopausal women, and this association was mainly evident in women with higher BMIs. On the other hand, among traditional indices of adiposity, only TSH was positively associated with BMI. Larger prospective studies are needed to evaluate the significance of the present findings.
Christopoulou ME, Mertzimekis TJ, Nomikou P, Papanikolaou D, Carey S, Mandalakis M. Influence of hydrothermal venting on water column properties in the crater of the Kolumbo submarine volcano, Santorini volcanic field (Greece). Geo-Marine Letters. 2015;36:1–10.Abstract
The Kolumbo submarine volcano, located 7 km northeast of the island of Santorini, is part of Santorini’s volcanic complex in the south Aegean Sea, Greece. Kolumbo’s last eruption was in 1650 AD. However, a unique and active hydrothermal vent field has been revealed in the northern part of its crater floor during an oceanographic survey by remotely operated vehicles (ROVs) in 2006. In the present study, conductivity-temperature-depth (CTD) data collected by ROV Hercules during three oceanographic surveys onboard E/V Nautilus in 2010 and 2011 have served to investigate the distribution of physicochemical properties in the water column, as well as their behavior directly over the hydrothermal field. Additional CTD measurements were carried out in volcanic cone 3 (VC3) along the same volcanic chain but located 3 km northeast of Kolumbo where no hydrothermal activity has been detected to date. CTD profiles exhibit pronounced anomalies directly above the active vents on Kolumbo’s crater floor. In contrast, VC3 data revealed no such anomalies, essentially resembling open-sea (background) conditions. Steep increases of temperature (e.g., from 16 to 19 °C) and conductivity near the maximum depth (504 m) inside Kolumbo’s cone show marked spatiotemporal correlation. Vertical distributions of CTD signatures suggest a strong connection to Kolumbo’s morphology, with four distinct zones identified (open sea, turbid flow, invariable state, hydrothermal vent field). Additionally, overlaying the near-seafloor temperature measurements on an X–Y coordinate grid generates a detailed 2D distribution of the hydrothermal vent field and clarifies the influence of fluid discharges in its formation.
Bone RN, Gai Y, Magrioti V, Kokotou MG, Ali T, Lei X, Tse HM, Kokotos G, Ramanadham S. Inhibition of Ca2+-independent phospholipase A2β (iPLA2β) ameliorates islet infiltration and incidence of diabetes in NOD mice. Diabetes. 2015;64:541-554.Abstract
Autoimmune β-cell death leads to type 1 diabetes and with findings that Ca2+-independent phospholipase A2β (iPLA2β) activation contributes to β-cell death, we assessed the effects of iPLA2β inhibition on diabetes development. Administration of FKGK18, a reversible iPLA2β inhibitor, to non-obese diabetic (NOD) mice significantly reduced diabetes incidence in association with (a) reduced insulitis, reflected by reductions in CD4+ T-cells and B-cells, (b) improved glucose homeostasis, (c) higher circulating insulin, and (d) β-cell preservation. Further, FKGK18 inhibited production of TNFα from CD4+ T-cells and antibodies from B-cells, suggesting modulation of immune cell responses by iPLA2β-derived products. Consistent with this, (a) adoptive transfer of diabetes by CD4+ T-cells to immunodeficient and diabetes-resistant NOD.scid mice was mitigated by FKGK18 pretreatment and (b) TNFα production from CD4+ T-cells was reduced by inhibitors of cyclooxygenase and 12-lipooxygenase, which metabolize arachidonic acid to generate bioactive inflammatory eicosanoids. However, adoptive transfer of diabetes was not prevented when mice were administered FKGK18-pretreated T-cells or FKGK18 administration is initiated with T-cell transfer. Our observations suggest that iPLA2β-derived lipid signals modulate immune cell responses, raising the possibility that early inhibition of iPLA2β may be beneficial in ameliorating autoimmune destruction of β-cells and mitigating type 1 diabetes development.
Kamberidou I. “Inspired Leaders–Empowering Leadership Skills: Women, Entrepreneurship and Sports”, pp. 28-30. Tips4skills conference, High Heels consortium, 19/2/2015, Athens, Greece [original in Greek]. In: Tips4skills conference, with support of the European Commission and the Lifelong Learning Programme of the European Union. High Heels consortium, EU project: http://www.highheelsproject.eu/; 2015. pp. 28–30.Abstract
Kamberidou, I. (2015). “Inspired Leaders–Empowering Leadership Skills: Women, Entrepreneurship and Sports”, pp. 28-30. Tips4skills conference, High Heels consortium, 19/2/2015, Athens, Greece [original in Greek]. In Tips4skills conference book, with support of the European Commission and the Lifelong Learning Programme of the European Union (pp. 28–30). High Heels consortium, EU project: http://www.highheelsproject.eu [Α.2.  in Apella]
tips4skills._empneysmeni_igesia.pdf high_heels_roundtable_outcomes._tips_4_skills_2015.pdf
Aissopou EK, Bournia V-K, Protogerou AD, Panopoulos S, Papaioannou TG, Vlachoyiannopoulos PG, Matucci-Cerinic M, Sfikakis PP. Intact calibers of retinal vessels in patients with systemic sclerosis. Journal of Rheumatology [Internet]. 2015;42(4):608 - 613. Website
Integrated History and Philosophy of Science in Practice. Special Issue of<em>Studies in History and Philosophy of Science.</em>
Integrated History and Philosophy of Science in Practice. Special Issue ofStudies in History and Philosophy of Science. Arabatzis T, Howard D. [Internet]. 2015;50:1-90. Publisher's Version
Kamberidou I. Interacting, sharing and bonding: 'notes of personal experience' by 19th century women travellers. Gender, Place & Culture: A Journal of Feminist Geography [Internet]. 2015:DOI–10. Publisher's VersionAbstract
 Full text:  http://www.tandfonline.com/eprint/QfxxQ5f9E7wVHtXDu7kB/full To cite this article: Irene Kamberidou (2015): Interacting, sharing and bonding: ‘notes of personal experience’ by nineteenth-century women travellers, Gender, Place & Culture: A Journal of Feminist Geography, DOI: 10.1080/0966369X.2015.1013451  To link to this article: http://dx.doi.org/10.1080/0966369X.2015.1013451
Karamitros T, Papatheodoridis G, Dimopoulou E, Papageorgiou M-V, Paraskevis D, Magiorkinis G, Sypsa V, Hatzakis A. The interferon receptor-1 promoter polymorphisms affect the outcome of Caucasians with HBeAg-negative chronic HBV infection. Liver Int. 2015;35(12):2506-13.Abstract
BACKGROUND & AIMS: The outcome of HBeAg-negative chronic hepatitis B virus (HBV) patients who may remain in the inactive carrier state (IC) or progress to HBeAg-negative chronic hepatitis B may be affected by the host genetic profile. Genetic polymorphisms within not only the promoter but also the coding sequence of the interferon receptor 1 (INFAR1) gene have been associated with susceptibility to chronic HBV infection, but their role on the outcomes of HBeAg-negative patients has not been evaluated. We examined the association of INFAR1 promoter polymorphisms with the phase of chronic HBV infection in a demographically characterized Caucasian cohort of 183 consecutive HBeAg-negative chronic HBV patients. METHODS: Using a combination of conventional and allele-specific polymerase chain reactions, bidirectional sequencing and DNA-fragment analysis, we performed typing of three Single Nucleotide Polymorphisms (SNPs -568G/C, -408C/T, -3C/T) and one Variable Number Tandem Repeat [VNTR -77(GT)n] within the INFR1 promoter sequence. RESULTS: The genetic polymorphisms examined were found to be associated with the phase of HBeAg-negative chronic HBV patients. Using a multiple logistic regression model adjusting for age, gender and origin of the individuals, we found that patients with linked genotypes -408CT_-3CT were more likely to be ICs (OR = 2.42 vs. CC, P = 0.036). Also, given the partial linkage between SNP -568G/C and VNTR -77(GT)n, we found that linked genotypes -77(GT)n ≤ 8/≤8_-568GC and -77(GT)n ≤ 8/≤8_-568CC were detected more frequently among ICs (OR = 11.69, P = 0.005 and OR = 7.56, P = 0.001 vs. -77(GT)n >8/>8_-568GG respectively). CONCLUSIONS: These findings suggest that these genetic variations represent important factors associated with the clinical phase of HBeAg-negative chronic HBV infection.
Arabatzis T, Howard D. Introduction: Integrated history and philosophy of science in practice. Studies in History and Philosophy of Science [Internet]. 2015;50:1-3. Publisher's Version
Kellici TF, Ntountaniotis D, Leonis G, Chatziathanasiadou M, Chatzikonstantinou AV, Becker-Baldus J, Glaubitz C, Tzakos AG, Viras K, Chatzigeorgiou P, et al. Investigation of the interactions of silibinin with 2-hydroxypropyl-β-cyclodextrin through biophysical techniques and computational methods. Molecular Pharmaceutics [Internet]. 2015;12(3):954 - 965. Website
Papadakis M, Lianou A, Nikolaou VS. Isolated Fracture of the Trapezoid. A Rare Injury. J Hand Microsurg. 2015;7(1):104-5.
Flessas K, Mylonas D, Panagiotaropoulou G, Tsopani D, Korda A, Siettos C, Di Cagno A, Evdokimidis I, Smyrnis N. Judging the judges’ performance in rhythmic gymnastics. Medicine & Science in Sports & Exercise. 2015;47:640–648.
Karakassi K, Kotelides G, Maier A, Papadopoulou V. Kafka in Griechenland: Haring E. DER KAFKA-ATLAS Ein Online-Projekt zur weltweiten Rezeption Franz Kafkas [Internet]. 2015. Publisher's Version
Aissopou EK, Papathanassiou M, Nasothimiou EG, Konstantonis GD, Tentolouris N, Theodossiadis PG, Papaioannou TG, Sfikakis PP, Protogerou AD. The Keith-Wagener-Barker and Mitchell-Wong grading systems for hypertensive retinopathy: Associationwith target organ damage in individuals below 55 years. Journal of Hypertension [Internet]. 2015;33(11):2303 - 2309. Website
Kopanias K. The King's Household, Royal Gifts and the International Trade in the Amarna Age. In: Lévy E Kingship in Ancient Greece: from Agamemnon to Cleopatra. International Conference in honor of Pierre Carlier. Athens, 6 – 8 February 2014. KTEMA, Civilisations de l’Orient, de la Grèce et de Rome antiques 40. Strasbourg: Université Marc Bloch de Strasbourg; 2015. pp. 199-206.
Bogdanis GC a, Kalapotharakos VI b. Knee Extension Strength and Hamstrings-to-Quadriceps Imbalances in Elite Soccer Players. International Journal of Sports Medicine [Internet]. 2015;37:119-124. WebsiteAbstract
{This study examined the relationship between hamstrings-to-quadriceps strength ratio (H:Q) and relative strength of the knee extensors in elite soccer players. Peak torque was measured during isokinetic knee extension/flexion at angular velocities of 60°·s-1, 180°·s-1 and 300°·s-1. 18 professional players were divided into 2 groups, depending on their H:Q at 60°·s-1. Players in the lower H:Q group (n=7) had significantly smaller H:Q ratios compared with the higher H:Q group (n=11) at all angular velocities (60°·s-1: 49.2%; 95% CI: 61.3-57.8% vs. 59.5%; 95% CI: 52.2-46.2%
Bogdanis, G.C.a KVI b. Knee Extension Strength and Hamstrings-to-Quadriceps Imbalances in Elite Soccer Players. International Journal of Sports Medicine [Internet]. 2015;37:119-124. WebsiteAbstract
{This study examined the relationship between hamstrings-to-quadriceps strength ratio (H:Q) and relative strength of the knee extensors in elite soccer players. Peak torque was measured during isokinetic knee extension/flexion at angular velocities of 60°·s-1, 180°·s-1 and 300°·s-1. 18 professional players were divided into 2 groups, depending on their H:Q at 60°·s-1. Players in the lower H:Q group (n=7) had significantly smaller H:Q ratios compared with the higher H:Q group (n=11) at all angular velocities (60°·s-1: 49.2%; 95% CI: 61.3-57.8% vs. 59.5%; 95% CI: 52.2-46.2%
Kritikou V. La proyección de los personajes infantiles en "Retirada" de Carmen Martín Gaite y "Los metales" de Onelio Jorge Cardoso. In: Estudios y Homenajes Hispanoamericanos III. Vol. 3. 1st ed. Madrid: Ediciones del Orto; 2015. pp. 131-135. Publisher's Version kritikou.personajes_infantiles.martin_gaite.jorge_cardoso.pdf
Katodritou E, Terpos E, Kastritis E, Delimpasis S, Symeonidis AS, Repousis P, Kyrtsonis M-C, Vadikolia C, Michalis E, Polychronidou G, et al. Lack of survival improvement with novel anti-myeloma agents for patients with multiple myeloma and central nervous system involvement: the Greek Myeloma Study Group experience. Annals of Hematology [Internet]. 2015;94(12):2033 - 2042. WebsiteAbstract
Involvement of the central nervous system (CNS) is a rare complication of multiple myeloma (MM). Herein, we have described the incidence, characteristics, prognostic factors for post CNS-MM survival, and outcome of CNS-MM and explored the efficacy of novel agents (NA) (thalidomide, bortezomib, lenalidomide) in this setting. Between 2000 and 2013, 31 (0.9 %) out of 3408 newly diagnosed symptomatic MM patients, consecutively diagnosed and treated during the same period in 12 Greek centers, developed CNS-MM (M/F 15/16, median age 59 years, range 20–96 years; newly diagnosed/relapsed-refractory 2/29; median time to CNS-MM diagnosis 29 months). Clinical and laboratory characteristics were retrospectively recorded. Twenty-six percent of patients had circulating plasma cells (PCs) or plasma cell leukemia (PCL) at CNS-MM and 39 % had skull-derived plasmacytomas, suggesting hematological and contiguous spread. Treatment for CNS-MM was offered in 29/31 patients and 11/29 responded (NA 18/29, additional radiotherapy 9/28, intrathecal chemotherapy 13/29). The median post CNS-MM survival was 3 months (95 % CI 1.9–4.1) and did not differ between patients treated with NA and/or radiotherapy vs. others. In the multivariate analysis, prior treatment of MM with NA, extramedullary disease (EMD) during MM course (i.e., plasmacytomas, circulating PCs, or documented PCL) and abnormally high LDH at MM diagnosis were independent prognostic factors, whereas treatment of CNS-MM with NA did not predict for post CNS-MM survival. Despite the relatively limited number of patients due to the rarity of CNS-MM, our results suggest that NA do not seem to improve post CNS-MM survival. Patients with EMD display shortened post CNS-MM survival and should be followed thoroughly. © 2015, Springer-Verlag Berlin Heidelberg.
Christodoulakis NS, Mamoucha S, Termentzi A, Fokialakis N. Leaf structure and histochemistry of the hardy evergreen Euphorbia characias L. (Mediterranean spurge). Flora: Morphology, Distribution, Functional Ecology of Plants [Internet]. 2015;210:13 - 18. WebsiteAbstract
The dorsiventral, hypostomatic leaf of Euphorbia characias is investigated to disclose its structural features and the chemical nature of the secondary metabolites produced. Light and scanning electron microscopy along with histochemical tests were employed to investigate the leaf of this well known perennial dwarf Mediterranean shrub. The compact leaf is characterized by numerous, rather uniform, curly, unicellular hairs on both surfaces, vaulty protrusions of the outer periclinal walls of the epidermal cells, prominent on the lower epidermis in particular, and a network of latex producing ducts (laticifers) extending in two layers within the mesophyll. Histochemical reactions proved positive only for alkaloids within the laticifers and phenolic compounds, especially for the condensed tannins accumulated within the vacuole of the epidermal cells. GC-MS and GC-FID analyses of the latex revealed the presence of several secondary metabolites, mainly belonging to the class of triterpenes. Lanosterol, butyrospermol, cycloartenol and lupeol were the major constituents in the extract examined. © 2014 Elsevier GmbH.
Pappas P, Paradisis G, Vagenas G. Leg and vertical stiffness (a)symmetry between dominant and non-dominant legs in young male runners. Human Movement Science [Internet]. 2015;40:273-274. Publisher's VersionAbstract
Biomechanical findings show that running is asymmetric in many kinetic properties. Running stiffness is a vital kinetic property of yet unknown pattern of lateralization. The aim of this study was to examine the degree and variability of lower limb dominance specific asymmetry of running in terms of leg stiffness, vertical stiffness, contact time, flight time, maximal ground reaction forceduring contact, vertical displacement of the center of mass, and change in leg length. Leg and vertical stiffness was estimated by the sine-wave method in 22 young males during treadmill runningat 4.44m/s. Lower limb dominance was determined by the triple jump test. Asymmetry was expressed as dominant – non-dominant, and indexed by the absolute asymmetry index. Significant asymmetry was found only in flight time (3.98%) and in maximal ground reaction force (1.75%). The absolute asymmetry index ranged from 1.8% to 6.4%, showed high variation between subjects (0–31.6%), and differentiated among the 7 analyzed variables. Leg and vertical stiffness in treadmill running of moderate pace (4.44 m/s) should be considered symmetric.
pappas_paradisis_vagenas_2015_hms.pdf
Mitsi E. “LET US PITY THE WHITE MAN, NO MOTHER HAS HE”: KINDNESS AND CRUELTY IN MUNGO PARK’S AFRICAN TRAVELS. In: People and Cultures in Contact. University of Pristina-Kosovska Mitrovica; 2015.
Sinanoglou, V.J. ZHPĆPGSPGC. Lipid and fatty acid profile of the edible fungus Laetiporus sulphurous. Antifungal and antibacterial properties. Journal of Food Science and Technology [Internet]. 2015;52:3264-3272. Website
Kritikos N, Tsantili-Kakoulidou A, Loukas YL, Dotsikas Y. Liquid chromatography coupled to quadrupole-time of flight tandem mass spectrometry based quantitative structure-retention relationships of amino acid analogues derivatized via n-propyl chloroformate mediated reaction. Journal of Chromatography A [Internet]. 2015;1403:70-80. Publisher's Version
Karakassi K. Literatur und Geschichte: Der Fall Kafka. In: Blažević Z History as a Foreign Country/Geschichte als ein fremdes Land.Historical Imagery in the South-Eastern Europe/Historische Bilder in Süd-Ost Europa. Bonn: Bouvier Verlag; 2015. pp. 247 - 262.
Daglis IA, Jacobi C, Pinnock M. Living with a star. A voyage through scales [Internet]. 2015:26-31. Publisher's Version
Kastritis E, Roussou M, Gavriatopoulou M, Migkou M, Kalapanida D, Pamboucas C, Kaldara E, Ntalianis A, Psimenou E, Toumanidis ST, et al. Long-term outcomes of primary systemic light chain (AL) amyloidosis in patients treated upfront with bortezomib or lenalidomide and the importance of risk adapted strategies. American Journal of Hematology [Internet]. 2015;90(4):E60 - E65. WebsiteAbstract
Bortezomib and lenalidomide are increasingly used in patients with AL amyloidosis, but long term data on their use as primary therapy in AL amyloidosis are lacking while early mortality remains significant. Thus, we analyzed the long term outcomes of 85 consecutive unselected patients, which received primary therapy with bortezomib or lenalidomide and we prospectively evaluated a risk adapted strategy based on bortezomib/dexamethasone to reduce early mortality. Twenty-six patients received full-dose bortezomib/dexamethasone, 36 patients lenalidomide with oral cyclophosphamide and low-dose dexamethasone and 23 patients received bortezomib/dexamethasone at a dose and schedule adjusted to the risk of early death. On intent to treat, 67% of patients achieved a hematologic response (24% hemCRs) and 34% an organ response; both were more frequent with bortezomib. An early death occurred in 20%: in 36% of those treated with full-dose bortezomib/dexamethasone, in 22% of lenalidomide-treated patients but only in 4.5% of patients treated with risk-adapted bortezomib/dexamethasone. Activity of full vs. adjusted dose bortezomib/dexamethasone was similar; twice weekly vs. weekly administration of bortezomib also had similar activity. After a median follow up of 57 months, median survival is 47 months and is similar for patients treated with bortezomib vs. lenalidomide-based regimens. However, risk adjusted-bortezomib/dexamethasone was associated with improved 1-year survival vs. full-dose bortezomib/dexamethasone or lenalidomide-based therapy (81% vs. 56% vs. 53%, respectively). In conclusion, risk-adapted bortezomib/dexamethasone may reduce early mortality and preserve activity while long term follow up indicates that remissions obtained with lenalidomide or bortezomib may be durable, even without consolidation with alkylators. © 2015 Wiley Periodicals, Inc.
Nikolaou VS, Petit A, Khoury V, Blain-Pare E, Zukor DJ, Huk OL, Antoniou J. Magnetic resonance imaging of painful metal-on-metal total hip replacement. Eur J Orthop Surg Traumatol. 2015;25(2):313-9.Abstract
Consecutive patients that had primary metal-on-metal (MoM) or metal-on-polyethylene (MoP) hip arthroplasty were prospectively enrolled to this study. All operated hips were evaluated with MRI by one radiologist who was blinded to the radiographic findings and clinical symptoms. Three groups of patients were formed: (1) thirteen MoM THRs in 13 patients with groin pain (Group 1), (2) ten MoM THRs in 10 patients with no pain (Group 2), (3) five MoP THRs in 4 patients without pain (control group). Abnormal MRI findings were distributed in all groups in a balanced way, irrespective of the patients' symptoms, prostheses, or metal ion levels. Two patients from Group 1 and one patient of Group 3 (control group) were diagnosed with a large periprosthetic mass (pseudotumor).
Vavuranakis M, Vrachatis DA, Siasos G, Aznaouridis K, Vaina S, Moldovan C, Kalogeras K, Kariori M, Bei E, Papaioannou TG, et al. Managing complications in transcatheter aortic valve implantation. Hellenic Journal of Cardiology [Internet]. 2015;56:20 - 30. Website
Matsangouras I, Nastos P, Pytharouris I, Kamperakis N. Medicanes: A prognostic analysis of November 7, 2014, case study based on ECMWF medium range products. 2015.
Chriti D, Grigoropoulos A, Raptopoulos G, Charalambidis G, Nikolaou V, Coutsolelos AG, Pitsikalis M, Mertis K, Paraskevopoulou P. Metathesis Polymerization Reactions Induced by the Bimetallic Complex (Ph4P) 2 [W2 (μ-Br) 3Br6]. Polymers. 2015;7(12):2611-2624.
Chriti D, Grigoropoulos A, Raptopoulos G, Charalambidis G, Nikolaou V, Coutsolelos AG, Pitsikalis M, Mertis K, Paraskevopoulou P. Metathesis polymerization reactions induced by the bimetallic complex (Ph4P)2[W2(μ-Br)3Br6]. Polymers [Internet]. 2015;7:2611-2624. PDF
Chriti D, Grigoropoulos A, Raptopoulos G, Charalambidis G, Nikolaou V, Coutsolelos AG, Pitsikalis M, Mertis K, Paraskevopoulou P. Metathesis polymerization reactions induced by the bimetallic complex (Ph4P)2[W2(μ-Br)3Br6]. Polymers [Internet]. 2015;7:2611-2624. Website
Kouvelioti R, Vagenas G. Methodological and Statistical quality in research evaluating nutritional attitudes in sports. International Journal of Spots Nutrition and Exercise Metabolism [Internet]. 2015;25(6):624-635. Publisher's VersionAbstract
The assessment of dietary attitudes and behaviors provides information of interest to sports nutritionists. Although there has been little analysis of the quality of research undertaken in this field, there is evidence of a number of flaws and methodological concerns in some of the studies in the available literature. This review undertook a systematic assessment of the attributes of research assessing the nutritional knowledge and attitudes of athletes and coaches. Sixty questionnaire-based studies were identified by a search of official databases using specific key terms with subsequent analysis by certain inclusion–exclusion criteria. These studies were then analyzed using 33 research quality criteria related to the methods, questionnaires, and statistics used. We found that many studies did not provide information on critical issues such as research hypotheses (92%), the gaining of ethics approval (50%) or informed consent (35%), or acknowledgment of limitations in the implementation of studies or interpretation of data (72%). Many of the samples were non-probabilistic (85%) and rather small (42%). Many questionnaires were of unknown origin (30%), validity (72%), and reliability (70%) and resulted in low (≤ 60%) response rates (38%). Pilot testing was not undertaken in 67% of the studies. Few studies dealt with sample size (2%), power (3%), assumptions (7%), confidence intervals (3%), or effect sizes (3%). Improving some of these problems and deficits may enhance future research in this field.
kouvelioti_vagenas_2016_ijsnem.pdf
Adamopoulos PG, Kontos CK, Rapti S-M, Papadopoulos IN, Scorilas A. MiR-224 overexpression is a strong and independent prognosticator of short-term relapse and poor overall survival in colorectal adenocarcinoma. International Journal of Oncology. 2015;46:849-859.
Coll CG, Motti-Stefanidi F, Oppedal B, Pavlopoulos V, Strohmeier D, van de Vijver F, Ali AA, Asendorpf J, Dimitrova R, Ferguson GM. MISSION STATEMENT Positive Development of Immigrant Youth: Why Bother?. SRCD/EADP/EARA Experts' Meeting on Immigrant Youth Adaptation and Well-being, Hydra, Greece [Internet]. 2015. pdf
Giannopoulos L, Papaparaskevas J, Refene E, Daikos G, Stavrianeas N, Tsakris A. MLST typing of antimicrobial-resistant Propionibacterium acnes isolates from patients with moderate to severe acne vulgaris. Anaerobe. 2015;31:50-4.Abstract
Molecular typing data on antimicrobial-resistant Propionibacterium strains are limited in the literature. We examined antimicrobial resistance profiles and the underlying resistance mechanisms in Propionibacterium spp. isolates recovered from patients with moderate to severe acne vulgaris in Greece. The clonallity of the resistant Propionibacterium acnes isolates was also investigated. Propionibacterium spp. isolates were detected using Tryptone-Yeast Extract-Glucose (TYG) agar plates supplemented with 4% furazolidone. Erythromycin, clindamycin, vancomycin, penicillin, co-trimoxazole, doxycycline, minocycline and ciprofloxacin MICs were determined using the gradient strip method. Erythromycin, clindamycin and tetracycline mechanisms of resistance were determined using PCR and sequencing of the domain V of 23S rRNA and 16S rRNA, as well as the presence of the ermX gene. Typing was performed using the multi locus sequence typing (MLST) methodology. Seventy nine isolates from 76 patients were collected. Twenty-three isolates (29.1%) exhibited resistance to erythromycin and clindamycin, while two additional isolates (2.5%) were resistant only to erythromycin. Resistance to tetracycline was not detected. The underlying molecular mechanisms were point mutations A2059G and A2058G. MLST typing of the P. acnes resistant isolates revealed that lineage type IA1 (ST-1, 3 and 52) prevailed (12/18; 66.7%), whilst lineage type IA2 (ST-2 and 22) accounted for five more isolates (27.8%). Susceptible isolates were more evenly distributed between ST types. Propionibacterium spp. from moderate to severe acne vulgaris in Greece are frequently resistant to erythromycin/clindamycin but not to tetracyclines, mainly due to the point mutations A2059G and A2058G. P. acnes resistant isolates were more clonally related than susceptible ones and belonged to a limited number of MLST types.
Tsilipanos K, Neokosmidis I, Varoutas D. Modeling Complex Telecom Investments: A System of Systems Approach. Engineering Management, IEEE Transactions on. 2015;62:631–642.
Batziou E, Koutsilianou V, Stavropoulos L, Psaltis A, Mertzimekis TJ. Modeling radiative proton-capture reactions in mid–heavy nuclei. In: Hellenic Nuclear Physics Society; 2015. Website
Paraskevis D, Kostaki E, Beloukas A, Cañizares A, Aguilera A, Rodríguez J, Grandal M, Pernas B, Castro-Iglesias A, Mena Á, et al. Molecular characterization of HIV-1 infection in Northwest Spain (2009-2013): Investigation of the subtype F outbreak. Infect Genet Evol. 2015;30:96-101.Abstract
BACKGROUND: HIV-1 subtype B is the predominant one in European regions several, while other subtypes and recombinants are also circulating with high prevalence. A sub-epidemic of subtype F with specific characteristics and low response to treatment has been recently identified in Galicia. In this study we investigated the characteristics of the HIV-1 subtype F sub-epidemic in A Coruña and Santiago de Compostela in Northwest Spain. METHODS: 420 newly HIV-1 diagnosed patients during 2009-2013 were enrolled in this study. HIV-1 subtyping was carried out using automated subtyping tools and phylogenetic analysis. Molecular epidemiology investigation of subtypes B and F was performed by means of phylogenetic analysis using fast maximum likelihood. Phylodynamic analysis was performed using Bayesian method as implemented in BEAST v1.8. RESULTS: Subtype B found to be the predominant (61.2% and 70.4%) followed by subtype F (25.6% and 12.0%) in both areas (A Coruña and Santiago de Compostela, respectively). The latter found to mainly spread among men having sex with men (MSM). The vast majority of subtype F lineages from both areas clustered monophyletically, while subtype B sequences clustered in several tree branches. The exponential growth of subtype F sub-epidemic dated back in 2008 by means of phylodynamic analysis. Most of new infections during 2009-2013 occurred within the subtype F transmission cluster. CONCLUSIONS: Subtype F circulates at high prevalence in A Coruña and Santiago de Compostela in Northwest Spain, suggesting that the HIV-1 epidemic in this region has distinct characteristics to the rest of Spain. Subtype F has being spreading among MSM and is currently the most actively spreading network. The single cluster spread of this local sub-epidemic might provide an explanation for the distinct characteristics and the low response to antiretroviral treatment.
Korres DS, Lazaretos J, Papailiou J, Kyriakopoulos E, Chytas D, Efstathopoulos NE, Nikolaou VS. Morphometric analysis of the odontoid process: using computed tomography-in the Greek population. Eur J Orthop Surg Traumatol. 2015.Abstract
AIM: A morphometric analysis of the odontoid process of the A2 vertebra, in the Greek population, was conducted using CT scan. We aimed to determine the feasibility to use one or two screws when treating fractures of this anatomic element. PATIENTS AND METHODS: One hundred and fifteen patients (57 men) of a mean age of 48 years (16-95 years) underwent a cervical spine CT scan examination. The anterior-posterior and transverse diameters of the odontoid process were measured from the base, at 1-mm interval upward on axial CT images. The length from the tip of the odontoid process to the anterior-inferior angle of the body of the axis was calculated. Data concerning the height and weight of the examined patients were collected. RESULTS: The mean transverse and anterior-posterior distances were found to be 11.46 and 10.45 mm, respectively, for the upper end of the odontoid process. At the neck level of the odontoid process, the equivalent mean values were 11.12 and 8.73 mm, respectively, while at the base, these distances were found to be 13.84 and 12.3 mm, respectively. The mean distance from the tip of the odontoid to its base was 17.25 and 17.28 mm, respectively, while the mean distance from the tip of the dens to the anterior-inferior corner of the axis' body was 39.2 mm. Men showed greater values than women. CONCLUSIONS: In this study, it was shown that in the Greek population there is enough room for one 4.5-mm or one 3.5-mm cannulated screw to be used. The application of two 3.5-mm screws is feasible in 58.6 % of the male and 26.3 % of the female population. This confirms that the knowledge of the true dimensions of the odontoid process is of paramount importance before the proper management of fractured dens using the anterior screw technique.
Kamberidou I. The Multiethnic Slavery Institution through the Eyes of Western Women and 'the real position of women in the religious system of Islam'. In: Media, Religion and Gender in Europe. 1st ed. Barcelona: Blanquerna Observatory on Media, Religion and Culture. Faculta de Comunicatio i Relacions Internacionals Blanquerna,Universitat Ramon Llull; 2015. pp. 53-79.Abstract
This chapter has shown that the multiethnic harem slavery institution was the Ottoman system’s primary socialization agent and an indispensable part of its self­-reproduction. It has contributed to the discourse on sexual slavery, primarily through the first-hand accounts of western women and harem inmates of the 19th century. It has shown that multiethnic–multiracial slavery was vital for the Ottoman economy and social system and provided a means of social integration-assimilation and social mobility: status and political power. Sexual slavery was a central part of the slave system and slaves of both genders were easily integrated into Ottoman society, eventually becoming free Muslims.       Mainly through the eyes of western women and harem inmates of the 19th century, corroborating that the harem system was based on slavery, this chapter has contributed additional evidence confirming that:  firstly, the expansionist views of Islam and the institution of slavery resulted in the multiethnic composition of the Ottoman households: harems and selemliks. Secondly, an Ottoman harem— especially that of the elite and so-called middle-class—was made up of women and children from different nations: Islamized slaves, liberated slaves and descendants of slaves, including islamized eunuchs. Thirdly, the Ottoman elite was responsible for the preservation of slavery until the early 20th century and, as a result, the prolongation of polygyny and the large-scale castration of African boys, which was another dehumanizing aspect of the Ottoman slavery institution.   Acknowledgments I would like to express my gratitude to the Greek artist Areti Kamperidis for her magnificent artwork, including her exceptional paintings, inspired by the female accounts and illustrated in this article.Keywords: human trafficking, slavery, sexual slavery, social mobility, polygyny, eunuchs, children’s harem, seraglio, marriage, divorce, veiling, gender, womenWHEN CITING: Kamberidou, I. (2015). The Multiethnic Slavery Institution through the Eyes of Western Women and 'the real position of women in the religious system of Islam'. In Miriam Diez Bosch and Jordi Sanchez Torrents (eds). Media, Religion and Gender in Europe (pp. 53-79). Barcelona: Blanquerna Observatory on Media, Religion and Culture. Faculta de Comunicatio i Relacions Internacionals Blanquerna,Universitat Ramon Llull.                     [Α.1. in Apella]    
media_religion_and_gender_in_europe_2015.pdf
Kamberidou I. The Multiethnic Slavery Institution through the Eyes of Western Women and 'the real position of women in the religious system of Islam'. In: Media, Religion and Gender in Europe. Barcelona: Blanquerna Observatory on Media, Religion and Culture. Faculta de Comunicatio i Relacions Internacionals Blanquerna,Universitat Ramon Llull. Copy at http://www.is.gd/1J2Y8D; 2015. pp. 53–79.Abstract
When citing: Kamberidou, I. (2015). The Multiethnic Slavery Institution through the Eyes of Western Women and 'the real position of women in the religious system of Islam'. In Miriam Diez Bosch and Jordi Sanchez Torrents (eds). Media, Religion and Gender in Europe (pp. 53-79). Barcelona: Blanquerna Observatory on Media, Religion and Culture. Faculta de Comunicatio i Relacions Internacionals Blanquerna,Universitat Ramon Llull.  DOI: 10.13140/RG.2.1.3034.4166 ·
media_religion_and_gender_in_europe_2015.pdf 1._book_media_religion_and_gender_in_europe_university_llull_barcelona.pdf
Stasinaki A-N, Gloumis G, Spengos K, Blazevich AJ, Zaras N, Georgiadis G, Karampatsos G, Terzis G. Muscle Strength, Power, and Morphologic Adaptations After 6 Weeks of Compound vs. Complex Training in Healthy Men. J Strength Cond Res. 2015;29(9):2559-69.Abstract
The aim of the study was to compare the effects of compound vs. complex resistance training on strength, high-speed movement performance, and muscle composition. Eighteen young men completed compound (strength and power sessions on alternate days) or complex training (strength and power sets within a single session) 3 times per week for 6 weeks using bench press, leg press, Smith machine box squat, and jumping exercises. Pre- and posttraining, jumping and throwing performance and maximum bench press, leg press, and Smith machine box squat strength were evaluated. The architecture of vastus lateralis and gastrocnemius muscle was assessed using ultrasound imaging. Vastus lateralis morphology was assessed from muscle biopsies. Jumping (4 ± 3%) and throwing (9 ± 8%) performance increased only with compound training (p < 0.02). Bench press (5 vs. 18%), leg press (17 vs. 28%), and Smith machine box squat (27 vs. 35%) strength increased after both compound and complex training. Vastus lateralis thickness and fascicle angle and gastrocnemius fascicle angle were increased with both compound and complex training. Gastrocnemius fascicle length decreased only after complex training (-11.8 ± 9.4%, p = 0.006). Muscle fiber cross-sectional areas increased only after complex training (p ≤ 0.05). Fiber type composition was not affected by either intervention. These results suggest that short-term strength and power training on alternate days is more effective for enhancing lower-limb and whole-body power, whereas training on the same day may induce greater increases in strength and fiber hypertrophy.
Kopanias K. The Mushki/Phrygian problem from the Near Eastern point of view. In: Stampolides N, Maner C, Kopanias K NOSTOI. Indigenous Culture, Migration and Integration in the Aegean Islands and Western Anatolia during the Late Bronze and Early Iron Age. Proceedings of the International Conference held in Istanbul 31/3/11-3/4/11. Istanbul: Koç University Press; 2015. pp. 211-226. Publisher's Version
Arabatzis T, Gavroglu K. Myth 18: That the Michelson-Morley Experiment Paved the Way for the Special Theory of Relativity. In: R. L. Numbers, K. Kampourakis (eds.), Newton's Apple and Other Myths about Science. Cambridge, MA: Harvard University Press; 2015. pp. 149-156, 254-255. Publisher's Version
Nikolopoulos GK, Fotiou A, Kanavou E, Richardson C, Detsis M, Pharris A, Suk JE, Semenza JC, Costa-Storti C, Paraskevis D, et al. National income inequality and declining GDP growth rates are associated with increases in HIV diagnoses among people who inject drugs in Europe: a panel data analysis. PLoS One. 2015;10(4):e0122367.Abstract
BACKGROUND: There is sparse evidence that demonstrates the association between macro-environmental processes and drug-related HIV epidemics. The present study explores the relationship between economic, socio-economic, policy and structural indicators, and increases in reported HIV infections among people who inject drugs (PWID) in the European Economic Area (EEA). METHODS: We used panel data (2003-2012) for 30 EEA countries. Statistical analyses included logistic regression models. The dependent variable was taking value 1 if there was an outbreak (significant increase in the national rate of HIV diagnoses in PWID) and 0 otherwise. Explanatory variables included the growth rate of Gross Domestic Product (GDP), the share of the population that is at risk for poverty, the unemployment rate, the Eurostat S80/S20 ratio, the Gini coefficient, the per capita government expenditure on health and social protection, and variables on drug control policy and drug-using population sizes. Lags of one to three years were investigated. FINDINGS: In multivariable analyses, using two-year lagged values, we found that a 1% increase of GDP was associated with approximately 30% reduction in the odds of an HIV outbreak. In GDP-adjusted analyses with three-year lagged values, the effect of the national income inequality on the likelihood of an HIV outbreak was significant [S80/S20 Odds Ratio (OR) = 3.89; 95% Confidence Interval (CI): 1.15 to 13.13]. Generally, the multivariable analyses produced similar results across three time lags tested. INTERPRETATION: Given the limitations of ecological research, we found that declining economic growth and increasing national income inequality were associated with an elevated probability of a large increase in the number of HIV diagnoses among PWID in EEA countries during the last decade. HIV prevention may be more effective if developed within national and European-level policy contexts that promote income equality, especially among vulnerable groups.
Kotopoulou I, Mertzimekis TJ, Godelitsas A, Price R, Fike DA, Amend JP, III GWP, Druschel GK. Natural Radioactivity in Marine Sediment Cores from the Shallow-Sea Hydrothermal System off Milos Island, Greece. [Internet]. 2015. Website
Tsang MA, Schneider JA, Sypsa V, Schumm P, Nikolopoulos GK, Paraskevis D, Friedman SR, Malliori M, Hatzakis A. Network Characteristics of People Who Inject Drugs Within a New HIV Epidemic Following Austerity in Athens, Greece. J Acquir Immune Defic Syndr. 2015;69(4):499-508.Abstract
BACKGROUND: Greece experienced an unprecedented increase in HIV cases among drug injectors in 2011 after economic crisis. Network-level factors are increasingly understood to drive HIV transmission in emerging epidemics. METHODS: We examined the relationship between networks, risk behaviors, and HIV serostatus among 1404 people who inject drugs in Athens, Greece. We generated networks using the chain-referral structure within a large HIV screening program. Network proportions, the proportion of a respondent's network with a given characteristic, were calculated. Multiple logistic regression models were used to assess the relationship between network proportions and individual HIV seroprevalence, injection frequency and unprotected sex. RESULTS: Of note, 1030 networks were generated. Respondent HIV seroprevalence was associated with greater proportions of network members who were HIV infected (ie, those with ≥ 50% of network members HIV positive vs. those with no network members HIV positive) (AOR: 3.11; 95% CI: 2.10 to 4.62), divided drugs (AOR: 1.60; 95% CI: 1.10 to 2.35), or injected frequently (AOR: 1.50; 95% CI: 1.02 to 2.21). Homelessness was the only sociodemographic characteristic associated with a risk outcome measure--high-frequency injecting (AOR: 1.41; 95% CI: 1.03 to 1.93). These associations were weaker for more distal second- and third-degree networks and not present when examined within random networks. CONCLUSIONS: Networks are an independently important contributor to the HIV outbreak in Athens, Greece. Network associations were strongest for the immediate network, with residual associations for distal networks. Homelessness was associated with high-frequency injecting. Prevention programs should consider including network-level interventions to prevent future emerging epidemics.
Dimaki M, Chondropoulos B, Legakis A, Valakos E, Vergetopoulos M. New data on the distribution and population density of the African Chameleon, Chamaeleo africanus and the Common Chameleon, Chamaeleo chamaeleon in Greece. Hyla. 2015;1:36-43.
Chrysostomou S. The new e-books and photodentro learning object repository in Greece: Teachers’ perceptions and practices in the arts’ classroom. INTED2015 9th International Technology, Education and Development Conference. 2015.
Mendonça S, Varoutas D, Verbrugge S. New empirical approaches to telecommunications economics: Opportunities and challenges. Telecommunications Policy. 2015;39:159–161.
Godelitsas A, Tzamos E, Filippidis A, Sokaras D, Wenk T-C, Griego G, Papadopoulos A, Stoulos S, Gamaletsos P, Mertzimekis TJ, et al. New Insights into the Mineral Chemistry of Au-Bearing pyrite/As-Pyrite/arsenopyrite Concentrate from Olympias Deposit, Kassandra Mines (Chalkidiki, Greece). In: Goldschmidt Conference 2015, 16-21 August 2015, Prague, Czech Republic. Vol. 1062. ; 2015. Website
Papaioannou TG, Vavuranakis M, Stefanadis C, Tousoulis D. New technological and clinical trends in blood pressure theranostics: Is it time to consider a spatio-temporal approach?. Current Pharmaceutical Design [Internet]. 2015;21(6):697 - 699. Website
Lagaki V, Kouvaris E, Mertzimekis TJ. A new γ-spectrometry station at the University of Athens. [Internet]. 2015. Website
Markatos K, Efstathopoulos N, Kaseta KM, Nikolaou V, Tsoucalas G, Sgantzos M. Nicholas J. Giannestras (1908-1978): a distinguished orthopaedic surgeon, his work, life and times. Int Orthop. 2015;39(11):2297-302.Abstract
The purpose of our study was to summarize all the knowledge concerning the innovative pioneer in the field of orthopaedic surgery, Nicholas J. Giannestras (1908-1978). A thorough study of texts, medical books and reports, in the field of history of medicine, together with a review of the available literature in PubMed, was undertaken. Giannestras left his mark in the history of orthopaedics with his clinical work and his publications, mainly his treatise "Foot Disorders: Medical and Surgical Management" (1973), while his name lingers in Greece with the introduction of spine fusion with the use of metallic implants. He was an eminent university clinical professor of orthopaedics who had harmonically combined academic writing, teaching and clinical research in every field of orthopaedic surgery.
NOSTOI. Indigenous Culture, Migration and Integration in the Aegean Islands and Western Anatolia during the Late Bronze and Early Iron Age. Proceedings of the International Conference held in Istanbul 31/3/11-3/4/11. (Stampolides N, Maner C, Kopanias K). Istanbul: Koç University Press; 2015. Website
Kordopati GG, Tselios TV, Kellici T, Merzel F, Mavromoustakos T, Grdadolnik SG, Tsivgoulis GM. A novel synthetic luteinizing hormone-releasing hormone (LHRH) analogue coupled with modified β-cyclodextrin: Insight into its intramolecular interactions. Biochimica et Biophysica Acta - General Subjects [Internet]. 2015;1850(1):159 - 168. Website
Diamantakos P, Velkou A, Killday BK, Gimisis T, Melliou E, Magiatis P. {Oleokoronal and Oleomissional: New major phenolic ingredients of extra virgin olive oil}. Olivae [Internet]. 2015;122:22–32. WebsiteAbstract
abstract extra virgin olive oil contains significant quantities of polar phenolic ingredients. The large majority is made up of esters of tyrosol or hydroxytyrosol with secoiridoid derivatives from oleuropein or ligstroside. in the current study we describe a number of new or incompletely characterized forms of ligstroside and oleuropein aglycons. two of them which are stable enolic forms are described for the first time as real olive oil ingredients although their presence in olive oil had been postulated. to minimize the confusion with the complicated names of the agly-con isomers we propose the names oleokoronal and oleomissional for the two ingredients. after screening 2000 samples of olive oil from most major varieties we were able to identify samples of olive oil in which oleokoronal and oleomissional were the major phenolic ingredients and could be used as starting material for their isolation. interestingly, during normal or reversed phase chromatography both compounds were transformed to the known forms of monoaldehydic closed ring aglycons, which offers an explanation as to why those compounds had not been identified so far. Their real presence in olive oil was confirmed by direct nMr observation without the use of any solvent.
Martzoukou O, Karachaliou M, Yalelis V, Leung J, Byrne B, Amillis S, Diallinas G. Oligomerization of the UapA purine transporter is critical for ER-exit, plasma membrane localization and turnover. J Mol Biol. 2015.Abstract
Central to the process of transmembrane cargo trafficking is the successful folding and exit from the ER through packaging in COPII vesicles. Here, we use the UapA purine transporter of Aspergillus nidulans to investigate the role of cargo oligomerization in membrane trafficking. We show that UapA oligomerizes (at least dimerizes) and that oligomerization persists upon UapA endocytosis and vacuolar sorting. Using a validated BiFC assay, we provide evidence that a UapA oligomerization is associated with ER exit and turnover, as ER-retained mutants, either due to modification of a Tyr-based N-terminal motif or partial misfolding, physically associate, but do not associate properly. Co-expression of ER-retained mutants with wild-type UapA leads to in trans plasma membrane localization of the former, confirming that oligomerization initiates in the ER. Genetic suppression of an N-terminal mutation in the Tyr motif and mutational analysis suggest that transmembrane α-helix 7 affects the oligomerization interface. Our results reveal that transporter oligomerization is essential for membrane trafficking and turnover and is a common theme in fungi and mammalian cells.
Matsangouras IT, Nastos PT. An online reposting system for tornadoes, waterspouts and funnel clouds activity over Greece: http//tornado. geol. uoa. gr. 2015.
Katavolos A. Operator algebras: an introduction. Serdica Math. J. 2015;41:49–82.
Zouros TJM, Kanellakopoulos A, Madesis I, Dimitriou A, Fernandez-Martin M, Martinez G, Mertzimekis TJ. The Optimization of a 4-Element Input Lens on a Hemispherical Deflector Analyzer Using SIMION. In: Ninth International Conference on Charged Particle Optics. Vol. 21(S4). ; 2015. pp. 148.
Krypotou E, Evangelidis T, Bobonis J, Pittis AA, Gabaldón T, Scazzocchio C, Mikros E, Diallinas G. Origin, diversification and substrate specificity in the family of NCS1/FUR transporters. Mol Microbiol. 2015.Abstract
NCS1 proteins are H(+) /Na(+) symporters specific for the uptake of purines, pyrimidines and related metabolites. In this article we study the origin, diversification and substrate specificity of fungal NCS1 transporters. We show that the two fungal NCS1 subfamilies, Fur and Fcy, and plant homologues, originate through independent horizontal transfers from prokaryotes, and that expansion by gene duplication led to the functional diversification of fungal NCS1. We characterized all Fur proteins of the model fungus Aspergillus nidulans and discovered novel functions and specificities. Homology modelling, substrate docking, molecular dynamics and systematic mutational analysis in three Fur transporters with distinct specificities identified residues critical for function and specificity, located within a major substrate binding site, in transmembrane segments TMS1, TMS3, TMS6 and TMS8. Most importantly, we predict and confirm that residues determining substrate specificity are located not only in the major substrate binding site, but also in a putative outward-facing selective gate. Our evolutionary and structure-function analysis contributes in the understanding of the molecular mechanisms underlying the functional diversification of eukaryotic NCS1 transporters, and in particular, forward the concept that selective channel-like gates might contribute to substrate specificity.
Kastritis E, Gavriatopoulou M, Dimopoulos MA, Eleutherakis-Papaiakovou E, Kanellias N, Roussou M, Pamboucas C, Toumanidis ST, Terpos E. Osteoprotegerin is a significant prognostic factor for overall survival in patients with primary systemic amyloidosis independent of the Mayo staging. Blood Cancer Journal [Internet]. 2015;5(6). WebsiteAbstract
Bone metabolism has not been systematically studied in primary (AL) amyloidosis. Thus we prospectively evaluated bone remodeling indices in 102 patients with newly diagnosed AL amyloidosis, 35 healthy controls, 35 newly diagnosed myeloma and 40 monoclonal gammopathy of undetermined significance patients. Bone resorption markers (C-telopeptide of type-1 collagen, N-telopeptide of type-1 collagen) and osteoclast regulators (soluble receptor activator of nuclear factor-κB ligand (sRANKL), osteoprotegerin (OPG)) were increased in AL patients compared with controls (P<0.01), but bone formation was unaffected. Myeloma patients had increased bone resorption and decreased bone formation compared with AL patients, while sRANKL/OPG ratio was markedly decreased in AL, due to elevated OPG in AL (P<0.001). OPG correlated with N-terminal pro-brain natriuretic peptide (P<0.001) and was higher in patients with cardiac involvement (P = 0.028) and advanced Mayo stage (P = 0.001). OPG levels above the upper value of healthy controls was associated with shorter survival (34 versus 91 months; P = 0.026), while AL patients with OPG levels in the top quartile had very short survival (12 versus 58 months; P = 0.024). In Mayo stage 1 disease, OPG identified patients with poor survival (12 versus 460 months; P = 0.012). We conclude that increased OPG in AL is not only a compensation to osteoclast activation but may also reflect early cardiac damage and may identify patients at increased risk of death within those with earlier Mayo stage.
Kastritis E, Gavriatopoulou M, Dimopoulos MA, Eleutherakis-Papaiakovou E, Kanellias N, Roussou M, Pamboucas C, Toumanidis ST, Terpos E. Osteoprotegerin is a significant prognostic factor for overall survival in patients with primary systemic amyloidosis independent of the Mayo staging. Blood Cancer Journal [Internet]. 2015;5. WebsiteAbstract
Bone metabolism has not been systematically studied in primary (AL) amyloidosis. Thus we prospectively evaluated bone remodeling indices in 102 patients with newly diagnosed AL amyloidosis, 35 healthy controls, 35 newly diagnosed myeloma and 40 monoclonal gammopathy of undetermined significance patients. Bone resorption markers (C-telopeptide of type-1 collagen, N-telopeptide of type-1 collagen) and osteoclast regulators (soluble receptor activator of nuclear factor-κB ligand (sRANKL), osteoprotegerin (OPG)) were increased in AL patients compared with controls (P<0.01), but bone formation was unaffected. Myeloma patients had increased bone resorption and decreased bone formation compared with AL patients, while sRANKL/OPG ratio was markedly decreased in AL, due to elevated OPG in AL (P<0.001). OPG correlated with N-terminal pro-brain natriuretic peptide (P<0.001) and was higher in patients with cardiac involvement (P=0.028) and advanced Mayo stage (P=0.001). OPG levels above the upper value of healthy controls was associated with shorter survival (34 versus 91 months; P=0.026), while AL patients with OPG levels in the top quartile had very short survival (12 versus 58 months; P=0.024). In Mayo stage 1 disease, OPG identified patients with poor survival (12 versus >60 months; P=0.012). We conclude that increased OPG in AL is not only a compensation to osteoclast activation but may also reflect early cardiac damage and may identify patients at increased risk of death within those with earlier Mayo stage.
Tsourou, T., DRINIA H, ANASTASAKIS G. Ostracod assemblages from Holocene middle shelf deposits of southern Evoikos Gulf (central Aegean Sea, Greece) and their palaeoenvironmental implications. Micropaleontology [Internet]. 2015;61:85-99. Publisher's Version
Morgan G, Palumbo A, Dhanasiri S, Lee D, Weisel K, Facon T, Delforge M, Oriol A, Zaki M, Yu X, et al. Overall survival of relapsed and refractory multiple myeloma patients after adjusting for crossover in the MM-003 trial for pomalidomide plus low-dose dexamethasone. British Journal of Haematology [Internet]. 2015;168(6):820 - 823. WebsiteAbstract
Summary: In the phase III MM-003 trial, pomalidomide plus low-dose dexamethasone (POM+LoDEX) improved overall survival (OS) versus high-dose dexamethasone (HiDEX) in 455 patients with relapsed and refractory multiple myeloma (RRMM) after treatment with bortezomib and lenalidomide. Here, a two-stage Weibull method was used to adjust for the crossover of patients in the HiDEX arm to pomalidomide-based therapy. The adjusted difference in median OS between patients in the POM+LoDEX and HiDEX arms was 7·0 months (12·7 vs. 5·7 months, respectively). These findings provide important evidence for understanding the clinical efficacy of pomalidomide on OS benefits seen in RRMM patients. © 2014 John Wiley & Sons Ltd.
Eleftheratos K, Kazadzis S, Zerefos CS, Tourpali K, Meleti C, Balis DS, Zyrichidou I, Lakkala K, Feister U, Koskela T, et al. Ozone and spectroradiometric UV changes in the past 20 years over high latitudes. Atmosphere-Ocean [Internet]. 2015;53:117-125. Publisher's Version a25_ao_2015.pdf
Ratopoulou M, Rousakis, G., Triantaphyllou, M., Gogou, A., Bouloubassi, I., Dimiza, M., Parinos, C., Lykousis V. A paleoceanographic approach of MIS5e interglacial deposits at the western margin of Cyclades plateau. 11th Panhellenic Symposium on Oceanography and Fisheries [Internet]. 2015;Proceeding:1001-1004. Publisher's VersionAbstract
Paleoceanographic proxies, such as marine micropaleontology, sedimentology and organic geochemistry havebeen performed in the sediment record of SK-3 gravity core (total length 217cm, water depth 249m) in order toprovide possible determination of late interglacial-Holocene the paleoenvironmental changes, at the southwestern margin of Cyclades plateau in the SW Aegean Sea. The sediment core exhibits two sapropels layer; thefirst one is associated with sapropel S1. The second sapropelic layer which we focus on represents anoxicconditions during the high sea-level warm event associated with sapropel S5 deposition.
Kouli K, Rousakis, G., Kyrikou, S., Ratopoulou, M., Triantaphyllou, M., Dimiza, M., Bouloubassi, I., Gogou, A., Kapsimalis, V., Lykousis V. Palynological investigation of the marine core SK-3 (SW Aegean Sea): implications on the vegetation of the last interglacial. 11th Panhellenic Symposium on Oceanography and Fisheries [Internet]. 2015;Proceeding:1009-1012. Publisher's VersionAbstract
Detailed pollen analyses were performed at the lower sapropelic deposits of the marine core SK-3 within theframework of a multiproxy palaeoceanographic-palaeoenvironmental study. Pollen flora is characterized byhigh arboreal pollen abundances, mainly deciduous Quercus, together with Pinus, Juniperus and otherdeciduous taxa. A transition is marked from vegetation where Mediterranean elements appear more abundanttowards mixed deciduous woodland. In the upper part of the deposits an expansion of Abies, Pinus and Fagushas been recorded. The overall vegetation pattern adds significant evidence about the terrestrialpalaeoenvironmental conditions during deposition of sapropel S5.
Richardson PG, Laubach JP, Lonial S, Moreau P, Yoon S-S, Hungria VT, Dimopoulos MA, Beksac M, Alsina M, San-Miguel JF. Panobinostat: A novel pan-deacetylase inhibitor for the treatment of relapsed or relapsed and refractory multiple myeloma. Expert Review of Anticancer Therapy [Internet]. 2015;15(7):737 - 748. WebsiteAbstract
Outcomes for patients with multiple myeloma (MM) have improved significantly over the past decade. Despite these advances, MM remains incurable and an unmet medical need remains for patients who are relapsed and/or refractory. Panobinostat is a potent, oral pan-deacetylase inhibitor that elicits anti-myeloma activity through epigenetic modulation of gene expression and disruption of protein metabolism. Preclinical data demonstrated that panobinostat has synergistic effects on myeloma cells when combined with bortezomib and dexamethasone. In a Phase III clinical trial evaluating bortezomib and dexamethasone in combination with panobinostat or placebo in patients with relapsed or relapsed and refractory MM (PANORAMA 1), panobinostat led to a significant increase in median progression-free survival. Panobinostat is currently under regulatory review with a recent accelerated approval granted for the treatment of relapsed disease, in which both bortezomib and immunomodulatory drugs have failed. Here, we summarize the preclinical, pharmacokinetic and clinical data for panobinostat in MM. © 2015 Informa UK, Ltd.
Tsapaki V, Tsalafoutas IA, Fagkrezos D, Lazaretos I, Nikolaou VS, Efstathopoulos N. PATIENT RADIATION DOSES IN VARIOUS FLUOROSCOPICALLY GUIDED ORTHOPAEDIC PROCEDURES. Radiat Prot Dosimetry. 2015.Abstract
All orthopaedic fluoroscopic procedures performed using C-arm guidance were monitored for 1 y. The type of procedure, fluoroscopy time (T), kerma-area product (KAP) values and number of radiographs (F) were recorded. The two most often performed techniques were as follows: intramedullary nailing (IMN) of intertrochanteric/peritrochanteric (IP) fractures (101 cases, 49.3 %) and antergrade IMN of femur or tibia shaft (TS) fractures (28 cases, 13.7 %). For the remaining procedures, none accounted for >5 %, categorised as 'various' (76 cases, 37 %). Large variations in T, KAP and F were observed. For IMN of IP fractures, antergrade IMN of femur and TS fractures and for various procedures, respectively, median values were T-2.1, 2.2 and 0.6 min, KAP-6.3, 6.3 and 0.6 Gy cm(-2) and F-21, 2.2 and 6.7. The patient doses during fluoroscopically guided procedures are relatively low compared with other interventional procedures.
Markatos K, Kaseta M, Nikolaou VS. Perioperative Skin Preparation and Draping in Modern Total Joint Arthroplasty: Current Evidence. Surg Infect (Larchmt). 2015;16(3):221-5.Abstract
BACKGROUND: Besides the vast success and reliability of lower extremity joint replacement, deep and periprosthetic infection remains a serious complication of such operations. Many publications addressing periprosthetic infection have remarked about this "devastating" complication, with a risk around 1% after total hip arthroplasty and between 1% and 2% after total knee arthroplasty. The purpose of this study is to assess current trends in prevention of contamination with improved up-to-date pre-operative skin preparation methods and intra-operative draping. METHODS: A literature review was conducted in MEDLINE, Web of Science, and the Cochrane database, looking for high-quality papers summarizing the most widely held and up-to-date concepts of perioperative measures for reducing infection, focusing on the best available evidence concerning skin preparation for joint arthroplasty (THR and THR) and surgical draping. RESULTS: Current evidence suggests the use of alcohol solutions for pre-operative painting with emphasis on the use of chlorhexidine gluconate solutions beginning the night before surgery. Hair removal should be performed in the operating room with electric clippers, not razor blades. In order to enhance drape adhesion to the skin, the use of iodophor-in-alcohol solutions is recommended over the traditional scrub-and-paint technique. Disposable non-woven drapes are superior to reusable woven cotton/linen drapes in resisting bacterial penetration. Finally, the use of adherent plastic adhesive incision drapes for the prophylaxis of post-operative surgical site infections is considered not necessary in orthopedic surgery. CONCLUSIONS: The importance of skin preparation and adequate and reliable draping cannot be overemphasized for infection prevention, especially in clean operations such as THR and TKR. Thorough and strict protocols are mandatory for every department, as well as education curricula for operating room personnel. Further randomized studies are mandatory to specify the effect of the above measures, their pitfalls, and their improvement, along with further crucial details such as cost-benefit analysis of different pre-operative preparations in preventing infections.
Vecchione M, Schwartz SH, Caprara GV, Schoen H, Cieciuch J, Silvester J, Bain P, Bianchi G, Kirmanoglu H, Baslevent C, et al. Personal values and political activism: A cross-national study. British Journal of Psychology. 2015;106:84–106.
Perverse fragments: citing Cavafy in crisis-stricken Athens. Journal of Greek Media & Culture [Internet]. 2015;1(2):191-205. Publisher's VersionAbstract
A publicity campaign run in Athens by the Alexander S. Onassis Public Benefit Foundation in October 2013 in order to advertise its acquisition of the Cavafy Archive, until then lying in relevant obscurity, turned into a media disaster when critics and members of the public protested against what they argued was a misquoting of the highly revered Alexandrian. In this paper, I am looking at this rather entertaining story of misunderstood intentions in order to suggest that even though Cavafy himself may be shown to have enjoyed history as fragmented experience, and despite the fact that the modern archive is one of often conflicting partialities rather than one of completeness, we, as consumers of Cavafy’s oeuvre, tend to sustain his long-established position as a paragon of Greek culture, canonised through his own nonconformity. As a typical case of ‘archive fever’, the events described here confirm the political specificity of any literary discourse, even when conducted out of context (or especially so).
Kellici TF, Liapakis G, Tzakos AG, Mavromoustakos T. Pharmaceutical compositions for antihypertensive treatments: A patent review. Expert Opinion on Therapeutic Patents [Internet]. 2015;25(11):1305 - 1317. Website
Orlowski RZ, Gercheva L, Williams C, Sutherland H, Robak T, Masszi T, Goranova-Marinova V, Dimopoulos MA, Cavenagh JD, Špička I, et al. A phase 2, randomized, double-blind, placebo-controlled study of siltuximab (anti-IL-6 mAb) and bortezomib versus bortezomib alone in patients with relapsed or refractory multiple myeloma. American Journal of Hematology [Internet]. 2015;90(1):42 - 49. WebsiteAbstract
We compared the safety and efficacy of siltuximab (S), an anti-interleukin-6 chimeric monoclonal antibody, plus bortezomib (B) with placebo (plc) + B in patients with relapsed/refractory multiple myeloma in a randomized phase 2 study. Siltuximab was given by 6 mg/kg IV every 2 weeks. On progression, B was discontinued and high-dose dexamethasone could be added to S/plc. Response and progression-free survival (PFS) were analyzed pre-dexamethasone by European Group for Blood and Marrow Transplantation (EBMT) criteria. For the 281 randomized patients, median PFS for S + B and plc + B was 8.0 and 7.6 months (HR 0.869, P = 0.345), overall response rate was 55 versus 47% (P = 0.213), complete response rate was 11 versus 7%, and median overall survival (OS) was 30.8 versus 36.8 months (HR 1.353, P = 0.103). Sustained suppression of C-reactive protein, a marker reflective of inhibition of interleukin-6 activity, was seen with S + B. Siltuximab did not affect B pharmacokinetics. Siltuximab/placebo discontinuation (75 versus 66%), grade ≥3 neutropenia (49 versus 29%), thrombocytopenia (48 versus 34%), and all-grade infections (62 versus 49%) occurred more frequently with S + B. The addition of siltuximab to bortezomib did not appear to improve PFS or OS despite a numerical increase in response rate in patients with relapsed or refractory multiple myeloma. © 2014 Wiley Periodicals, Inc.
Kouli K. Plant landscape and land use at the Neolithic lake settlement of Dispilió (Macedonia, Northern Greece). Plant Biosystems [Internet]. 2015;149(1):145-204. Publisher's VersionAbstract
The Neolithic settlement of Dispilió (lake Orestiás, northern Greece) is a unique site due to its continual inhabitation from the Middle Neolithic (5400 BC) to the Chalcolithic (3600 BC) and its exceptional location at the shore of Lake Orestiás (also known as Lake Kastoria). The plant landscape shaping of the area has been examined by correlating pollen and non-pollen palynomorphs (NPPs) from both on-site and off-site records. The examined pollen profiles bear concrete evidence of agricultural activities and land use in the area. The local pollen assemblages identified, each of them corresponding either to a different kind or intensity of exploitation of natural resources, display the diachronic evolution of the cultural landscape during more than 2000 years of human activity. The successive phases of intense human impact on vegetation patterns are in good accordance with the periods of major constructing activities described by the archaeological study of the Dispilió settlement. Finally, the differences on palynomorph accumulation pathways of the examined records made possible the distinction between local and “regional” plant landscapes and related human activities.
Gargalionis AN, Korkolopoulou P, Farmaki E, Piperi C, Dalagiorgou G, Adamopoulos C, Levidou G, Saetta A, Fragkou P, Tsioli P, et al. Polycystin-1 and polycystin-2 are involved in the acquisition of aggressive phenotypes in colorectal cancer. Int J Cancer. 2015;136(7):1515-27.Abstract
The polycystins PC1 and PC2 are emerging as major players in mechanotransduction, a process that influences all steps of the invasion/metastasis cascade. We hypothesized that PC1 and PC2 facilitate cancer aggressiveness. Immunoblotting, RT-PCR, semi-quantitative and quantitative real-time PCR and FACS analyses were employed to investigate the effect of polycystin overexpression in colorectal cancer (CRC) cells. The impact of PC1 inhibition on cancer-cell proliferation was evaluated through an MTT assay. In vitro data were analyzed by Student's t-test. HT29 human xenografts were treated with anti-PC1 (extracellular domain) inhibitory antibody and analyzed via immunohistochemistry to determine the in vivo role of PC1 in CRC. Clinical significance was assessed by examining PC1 and PC2 protein expression in CRC patients (immunohistochemistry). In vivo and clinical data were analyzed by non-parametric tests, Kaplan-Meier curves, log-rank test and Cox model. All statistical tests were two-sided. PC1 overexpression promotes epithelial-to-mesenchymal transition (EMT) in HCT116 cells, while PC2 overexpression results in upregulation of the mTOR pathway in SW480 cells. PC1 inhibition causes reduced cell proliferation in CRC cells inducing tumor necrosis and suppressing EMT in HT29 tumor xenografts. In clinical study, PC1 and PC2 overexpression associates with adverse pathological parameters, including invasiveness and mucinous carcinomas. Moreover, PC1 overexpression appears as an independent prognostic factor of reduced recurrence-free survival (HR = 1.016, p = 0.03) and lowers overall survival probability, while aberrant PC2 expression predicts poor overall survival (p = 0.0468). These results support, for the first time, a direct link between mechanosensing polycystins (PC1 and PC2) and CRC progression.
Richardson PG, Palumbo A, Schey SA, Dimopoulos MA, Facon T, Weisel KC, O'Gorman P, Leleu X, Lacy MQ, Streetly MJ, et al. Pomalidomide - An appraisal of its clinical development and role in the treatment of relapsed/refractory multiple myeloma. European Oncology and Haematology [Internet]. 2015;11(2):109 - 117.